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Query: [R] KOG3518 Putative guanine nucleotide exchange factor, from COG1018

Results of FFAS03 search in NEW_HUMAN_DOMAINS
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MCAAQAHQHCSTSVAGDRLLGSSTELAPSLLGIYDTLTNSFAAGGVAAAPTATSHESKASSSGDSTPKRSNSNCSSSSSTGSSTGSCSSVPTSDDQSASYTLASSSTHLGHQEPPAPLVVAGLRDEPDGAQLSRLVQRRSQESQIHGSSSSIASSGSSRRGSNIRILSPNVHRIITHSDIQPVEAVSAEALKQHQQQSQRSPTQGRYIKTGHSGTPPAAGSAPKLKLSHIPLSKITGKLSTQSGSELVSTFDSSNEYLNSVAFAAFEKSKPQDEDRTPTNKSVPGTPFHFDGHPFQGRKLTLPRYDSQQSIKLIEMEQLAATSAQLLHAKPATPGTPATPTPSATKAKEFVCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEGECFPLGLast
1 -4.790sp|Q9NRR4|RNC_HUMAN Ribonuclease 3 OS=Homo sapiens GN=DROSHA PE=1 SV=2  ali   9  2.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DRLHDELWYNDPGQMND-TGIRHSIYP------EEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIDHEYI-----FEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMCVKGLELFSLFLFRDILELYDWNLKGPLFE---DSPPCCPRFHFMPRFVRFLPD------GGKEVLSMHQILLYL----LRCSKALVPEEEIANMLQWEELEWCKGMIVTNPGTK-------PSSVRIDQLD--EQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSKLRHL............................. 289
2 -4.740sp|Q9P2D8|UNC79_HUMAN Protein unc-79 homolog OS=Homo sapiens GN=UNC79 PE=2 SV=3  ali   9  2...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LLPEDAGIDHQTVHQLITVLMKFMAKDEESDISSAKAFNTVKRHLYVLLGYDQQFIAGIAQVMDYNINLGKHLL----------------PLVVQVLKYCSCPQLRHYFQQPPRCSL--------WSLKPHIRQMWLKALLVILYKYPRDCDISKILLHLIHIT--VNTLNAQYH................................................................................................................................................. 173
3 -4.740sp|Q8IY22|CMIP_HUMAN C-Maf-inducing protein OS=Homo sapiens GN=CMIP PE=1 SV=3  ali   11  2..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KKKIYKYKKVLSNPSRWE-VVLKEIRTLVDMALTSPLQDDSINQAPLEIVSKLLSENTNLTTQEHENI-------VAIAPLLENNHPPPDLFCKHCRERPRSMVVIE----------------------------VFTPVQRILKHNMFTQEYILALNELN--AGMEVVKKFIQSMHGPTGHCPHPRVLPNLVAV...................................................................................................................................... 173
4 -4.460sp|Q69YN4|VIR_HUMAN Protein virilizer homolog OS=Homo sapiens GN=KIAA1429 PE=1 SV=2  ali   10  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TELLDLGAKWVTALEEIPSLIIKGLSYLQLKNTKQD------LGQLVDWTMQAL-NLQVALRQPIALNVRQLK---GTKLVSSLAECGAQGVTGLLQAGVISGLFELLFADHVSSSLKLGMEAFLRGRQNEKSGYQKLLELILL-----------DQTVRVVTAGSAILQKCHFYEVLSEIK........................................................................................................................................ 182
5 -4.270sp|Q8NCM8|DYHC2_HUMAN Cytoplasmic dynein 2 heavy chain 1 OS=Homo sapiens GN=DYNC2H1 PE=1 SV=4  ali   7  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KEL----EGYIQKLQNAAERLATENRKLRKWHTT----FCEKVVVLMNIDKDGLQELRTGLATVEAQGHAWKQHWNH-QLYKALEHQYQMGLEALNENLPEINIDLTYKQGRLQFRPPFEIRAKYYREMKRFIGIPNQFKGVGEAGDESIFSIMIDRNASGFLTIFSKAEDL-----FRRLSAVLHQH-----KEWIVIGQVDMEALVEKHLFTVHDWEKNFKALKIKGKEVERLPSAVKVDCLNI--------------------NCNPVKTVIDDLIQKLFDLLVLSLKKSIQAHLHEIDTFVTEAME........ 286
6 -4.020sp|Q9Y4B6|VPRBP_HUMAN Protein VPRBP OS=Homo sapiens GN=VPRBP PE=1 SV=3  ali   12  2....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TTVVVHVDSKAELTTLLEQWEKEHGS-LTRMSQLIEKYRKGDPDPFD-GRADPECMLGHLLRILFKNDDFMNALVN-----------YVMTSREPPLNTAACR-------LLLDIMPGLETAVVFQEKEGIVEN---LFKWAREADQPLRTYSTLLGGAMENQDIAARDENSQLVAIVLRRLR........................................................................................................................................................ 180
7 -3.950sp|Q86UQ4|ABCAD_HUMAN ATP-binding cassette sub-family A member 13 OS=Homo sapiens GN=ABCA13 PE=2 SV=3  ali   11  1...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NLAFLKEIQDLAEEIHGMMDKAKNLKRNKTEEVILKLESLHQ---DFLLLLPRLHTSHDHV-------EDGMDVAVNLLQTILNSLISLEDLDWLPLNQTFSQVSELVLNYHLSMQNIVWDPTEQILNSSAELKEIPTDTSLEKM....................................................................................................................................................................... 199
8 -3.930sp|A6NNL5|CO061_HUMAN Uncharacterized protein C15orf61 OS=Homo sapiens GN=C15orf61 PE=2 SV=2  ali   9  2...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EALRRAHEVALRLLLCRPWASRAASEVLTRHLLQRRLPH-------TSFCVPYSAVRNDQSHFNWPVQGANYHVLRTG-CF---------FIKYCSKAPWQDLARQN--------RFFTALKVV---NLGIPTLL---------YGLGSWLFARVTETVHTSYGPITVYFLNKEDEGAMY.................................................................................................................................................... 157
9 -3.870sp|Q9P2D7|DYH1_HUMAN Dynein heavy chain 1, axonemal OS=Homo sapiens GN=DNAH1 PE=1 SV=4  ali   19  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QTEK----DIDLTRMEYIP---------AIRTQILFANVDPMYQYSNIFLSGIANSERADNLKKRI-INRYLTYSLYSNVCRS-------------------LFEKHKLMFAFLLCVR--IMMNEGKINEWRYLLS.................................................................................................................................................................................. 117
10 -3.840sp|Q8WXX0|DYH7_HUMAN Dynein heavy chain 7, axonemal OS=Homo sapiens GN=DNAH7 PE=1 SV=2  ali   20  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ETEK----KIDTTRMGYRP---------AIHSSILFANIEPMYQYSNLFILSIENSEKSEILAKRLILKDHFTYSLYVNVCRS-------------------LFEKDKLLFSFCLTIN--LLLHERAINEWRFLLT.................................................................................................................................................................................. 117
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 6   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Sequence clustering strategies improve remote homology recognitions while reducing search times. Protein Eng. 2002 Aug;15(8):643-9.