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Query: [G] COG0362 6-phosphogluconate dehydrogenase, from COG1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSVKGDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKGTNIIGAYSLEDLAAKLEKPRKVMLMVRAGDVVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAEKGIRFIGSGVSGGEEGARHGPSIMPGGNQEAWQYVKPIFQAISAKTEQGEPCCDWVGGEGAGHFVKMVHNGIEYGDMQLICEAYQFLKEGLGLSYEEMQAIFAEWKNTELDSYLIDITTDILGYKDASGEPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKDQRVAANQLFGKTITPVEGDKKVWIEAVRKALLASKIISYAQGFMLIREASEQFGWDINYGATALLWREGCIIRSRFLGNIRDAYEANPNLVFLGSDSYFKGILENALSDWRKVVAKSIEVGIPMPCMASAITFLDGYTSARLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGNTASTTYDVLast
1 -120.0001pgn_A mol:protein length:482 6-PHOSPHOGLUCONATE DEHYDROGENASE  ali model follow..  62  1..AQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVLGAHSLEEMVSKLKKPRRIILLVKAGQAVDNFIEKLVPLLDIGDIIIDGGNSEYRDTMRRCRDLKDKGILFVGSGVSGGEDGARYGPSLMPGGNKEAWPHIKAIFQGIAAKVGTGEPCCDWVGDDGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGLGHKEMAKAFEEWNKTELDSFLIEITASILKFQDADGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLGPQNIPFEGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPGLQNLLLDDFFKSAVENCQDSWRRAISTGVQAGIPMPCFTTALSFYDGYRHAMLPANLIQAQRDYFGAHTYELLAKP-GQFIHTNWTGHGGSVSSSSYNA 482
2 -120.0002p4q_A mol:protein length:497 6-phosphogluconate dehydrogenase, decarboxylating 1  ali model follow..  59  1MGMSADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANEAKGKSIIGATSIEDFISKLKRPRKVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKGILFVGSGVSGGEEGARYGPSLMPGGSEEAWPHIKNIFQSISAKS-DGEPCCEWVGPAGAGHYVKMVHNGIEYGDMQLICEAYDIMKRLGGFTDKEISDVFAKWNNGVLDSFLVEITRDILKFDDVDGKPLVEKIMDTAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSALKNERIRASKVLPEVPKDAVKDREQFVDDLEQALYASKIISYAQGFMLIREAAATYGWKLNNPAIALMWRGGCIIRSVFLGQITKAYREEPDLENLLFNKFFADAVTKAQSGWRKSIALATTYGIPTPAFSTALSFYDGYRSERLPANLLQAQRDYFGAHTFRVLPEPVDKDIHINWTGHGGNVSSSTYQA 491
3 -119.0002jkv_A mol:protein length:505 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING  ali model follow..  61  17.MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKP-GQFIHTNWTGHGGTVSSSSYNA 499
4 -116.0005uq9_A mol:protein length:489 6-phosphogluconate dehydrogenase, decarboxylating  ali model follow..  61  6IMAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKP-GQFIHTNWTGHGGTVSSSSYNA 489
5 -115.0002zyg_A mol:protein length:480 6-phosphogluconate dehydrogenase, decarboxylating  ali model follow..  52  1MGMKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENPGK-KLVPYYTVQEFVESLETPRRILLMVKAGAGTDSAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGTLKGPSIMPGGQKEAYELVAPILKQIAAVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYALLKGGLALSNEELAQTFTEWNEGELSSYLIDITKDIFTKKDEEGKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYISSLKDQRVAASKVLSGPQAQPAGDKAEFIEKVRRALYLGKIVSYAQGFSQLRAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAQNAGIANLLLAPYFKQIADDYQQALRDVVAYAVQNGIPVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDKE--GIFHTEWLE............ 470
6 -115.0002zya_A mol:protein length:480 6-phosphogluconate dehydrogenase, decarboxylating  ali model follow..  52  1MGMKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIAENPGK-KLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAAVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEWNNGELSSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKDQRVAASKVLSGPQAQPAGDKAEFIEKVRRALYLGKIVSYAQGFSQLRAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDACAENPQIANLLLAPYFKQIADDYQQALRDVVAYAVQNGIPVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDKE--GVFHTEWLD............ 470
7 -110.0002iz0_A mol:protein length:474 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING  ali model follow..  53  3MA-QANFGVVGMAVMGKNLALNVESRGYTVAIYNRTTSKTEEVFKEHQD-KNLVFTKTLEEFVGSLEKPRRIMLMVQAGAATDATIKSLLPLLDIGDILIDGGNTHFPDTMRRNAELADSGINFIGTGVSGGEKGALLGPSMMPGGQKEAYDLVAPIFEQIAAKAPDGKPCVAYMGANGAGHYVKMVHNGIEYGDMQLIAESYDLLKRILGLSNAEIQAIFEEWNEGELDSYLIEITKEVLKRKDDEGEGYIVDKILDKANKGTGKWTSESALDLGVPLPLITESVFARYISTYKDERVKASKVLSGPALDFSGDKKEVIEKIRKALYFSKIMSYAQGFAQLRKASEEFDWDLPYGTIAQIWRAGCIIRAEFLQNITDAFDKDSELENLLLDDYFVDITKRYQEAVRDVVSLAVQAGTPIPTFTSAISYYDSYRSENLPANLIQAQRDYFGAHTYERTDKA--GIFHYDWYTED.......... 474
8 -107.0002w90_A mol:protein length:471 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING  ali model follow..  56  3MA-KHQIGVIGLAVMGKNLALNIESKGYSVAVYNRLREKTDEFLQE-AKGKNIVGTYSIEEFVNALEKPRKILLMVKAGAPTDATIEQLKPHLEKGDIVIDGGNTYFKDTQRRNKELAELGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVRPIFEAIAAKV-DGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYFLLKHVLGMDAAELHEVFADWNKGELNSYLIEITADIFTKIDEETGKPLVDVILDKAQKGTGKWTSQNALDLGVPLPIITESVFARFLSAMKDERVKASKVLAGAVKPFEGDRAHFIEAVRRALYMSKICSYAQGFAQMKAASEEYNWNLRYGDIAMIFRGGCIIRAQFLQKIKEAYDRDPALSNLLLDSYFKDIVERYQDALREIVATAAMRGIPVPGSASALAYYDSYRTAVLPANLIQAQRDYFGAHTYERVDKE--GIFHTEWLK............ 471
9 -106.0001pgj_A mol:protein length:478 6-PHOSPHOGLUCONATE DEHYDROGENASE  ali model follow..  33  1...SMDVGVVGLGVMGANLALNIAEKGFKVAVFNRTYSKSEEFMKANASAGNLKAFETMEAFAASLKKPRKALILVQAGAATDSTIEQLKKVFEKGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKADDGRPCVTMNGSGGAGSCVKMYHNSGEYAILQIWGEVFDILRAMGLNNDEVAAVLEDWKSKNFLKSYMLDISIAAARAKDKDGSYLTEHVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQANASNAPGYTLKNKSPSGPEIKQLYDSVCIAIISCYAQMFQCLREMDKVHNFGLNLPATIATFRAGCILQGYLLKPMTEAFEKNPNISNLM--CAFQTEIRAGLQNYDMVALITSKLEVSIPVLSASLNYVTAMFTPTLKGQLVSLQRDVFGRHGYERVDKD--GRESFQWPELQ.......... 478
10 -104.0006fqx_A mol:protein length:468 6-phosphogluconate dehydrogenase, decarboxylating  ali model follow..  42  2....CDIGLIGLAVMGQNLSLNISSKGFKIGVYNRTYERTEETMKRAKENLVVYGYKTVEELINNLKKPRKVILLIKAGPAVDENISNILKHFEKGDIIIDGGNEWYINSERRIKLCKEKDVEYLAMGVSGGEAGARYGCSFMPGGSKYAYDCVKEILEKCSAQV-GNSPCVTYIGPGSSGNYVKMVHNGIEYGDMQLISESYVIMKHILKYDNQKLSEVFNKWNEGILNSYLIEITANILAKKDDLTNNYLVDMILDIAAKGTGKWTMLEATERGIPCPTMCAALDARNISVFKELRTKAESNFNKILIDPNEDLNDFENDLLNALYCCKIISYTQGLFLLKQVSEEMNWKLNLGEIARIWRGGCIIRAVFLDRIANAYKNNEKLELLFLDNEFSDDIKNKLPSLRKIVLMATKYSIPIPAFSASLAYFQMVTSQNLPLNLVQAQRDYFGSHTYRRTDRE--GNYHTLW.............. 468
11 -69.4004e21_A mol:protein length:358 6-phosphogluconate dehydrogenase (Decarboxylating)  ali model follow..  30  13YFQSMQIGMIGLGRMGADMVRRLRKGGHECVVYDLNVNAVQALEREGIA-----GARSIEEFCAKLVKPRVVWLMVPA-AVVDSMLQRMTPLLAANDIVIDGGNSHYQDDIRRADQMRAQGITYVDVGTSGGIFGLERGYCLMIGGEKQAVERLDPVFRTLAPGIGTAELGYLHCGPSGAGHFVKMVHNGIEYGLMAAYAEGLNILHHANAGKEGQGADA----ETAPLRNPDFY------------------------------------------------------------------------------------------------------------------RYDLDLADITEVWRRGSVISSWLLDLSATALLDSPDLQEFQ-------GRVSDSGEGRWTVAAAIDEGVPAHVLSSALYRFSSRGEDDFANRLLSAMRYEFGGHREKS........................... 352
12 -60.5003w6u_A mol:protein length:306 6-phosphogluconate dehydrogenase, NAD-binding protein  ali model follow..  20  12.GSHMRVGFIGLGIMGGPMATHLLKAGFLAAVYNRTREKTKPFAEAGVY-----VAESPADLAKRVDVVIVMVSDAPDVEQVLFGPSGVVEGARPGLIVVDMSTNSPDWARKFAERLAQYGIEFLDAPVTGGQKGAIEGLTIMVGGKEELFHRLLPIFKAMGRD-------IVYMGPVGYGQAMKLVNQVVVALNTVAMVEGLKLAKALGLDM----DKVAEVLTRGAARSGAIELYLPKLLKGDLSPGFKAEHLKKDLGYVLEEARKRGVKLPGAELAYELYRKMVEDGAGSLGIHAL......................................................................................................................................................................................... 294
13 -60.3001vpd_A mol:protein length:299 TARTRONATE SEMIALDEHYDE REDUCTASE  ali model follow..  15  2NAMTMKVGFIGLGIMGKPMSKNLLKAGYSLVVSDRNPEAIADVIAAGAE-----TASTAKAIAEQCDVIITMLPNSPHVKEVALGENGIIEGAKPGTVLIDMSSIAPLASREISDALKAKGVEMLDAPVSGGEPKAIDGLSVMVGGDKAIFDKYYDLMKAMAGS-------VVHTGDIGAGNVTKLANQVIVALNIAAMSEALTLATKAGVNP----DLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIKDLANALDTSHGVGAQLPLTAAVMEMMQALRADGHGNDDHSAL......................................................................................................................................................................................... 285
14 -59.2003pef_A mol:protein length:287 6-phosphogluconate dehydrogenase, NAD-binding  ali model follow..  18  1...SQKFGFIGLGIMGSAMAKNLVKAGCSVTIWNRSPEKAEELAALGAE-----RAATPCEVVESCPVTFAMLADPAAAEEVCFGKHGVLEGIGEGRGYVDMSTVDPATSQRIGVAVVAKGGRFLEAPVSGSKKPAEDGLIILAAGDRNLYDEAMPGFEKMGKK-------IIHLGDVGKGAEMKLVVNMVMGGMMACFCEGLALGEKAGLAT----DAILDVIGAGAMANPMFALKGGLIRDRNFAPAFPLKHMQKDLRLAVALGDRVGQPLVASAAANELFKGARAAGFGDEDFSAI......................................................................................................................................................................................... 281
15 -59.1003cky_A mol:protein length:301 2-hydroxymethyl glutarate dehydrogenase  ali model follow..  22  1MEKSIKIGFIGLGAMGKPMAINLLKEGVTVYAFDLMEANVAAVVAQGAQ-----ACENNQKVAAASDIIFTSLPNAGIVETVMNGPGGVLSACKAGTVIVDMSSVSPSSTLKMAKVAAEKGIDYVDAPVSGGTKGAEAGLTIMVGASEAVFEKIQPVLSVIGKD-------IYHVGDTGAGDAVKIVNNLLLGCNMASLAEALVLGVKCGLKP----ETMQEIIGKSSGRSYAMEAKMEFIMSGDFAGGFAMDLQHKDLGLALEAGKEGNVPLPMTAMATQIFEGGRAMGLGREDMSAV......................................................................................................................................................................................... 285
16 -59.1001yb4_A mol:protein length:295 tartronic semialdehyde reductase  ali model follow..  19  1.SNAMKLGFIGLGIMGSPMAINLARAGHQLHVTTIGP-VADELLSLGAV-----NVETARQVTEFADIIFIMVPDTPQVEDVLFGEHGCAKTSLQGKTIVDMSSISPIETKRFAQRVNEMGADYLDAPVSGGEIGAREGLSIMVGGEQKVFDRVKPLFDILGKN-------ITLVGGNGDGQTCKVANQIIVALNIEAVSEALVFASKAGADP----VRVRQALMGGFASSRILEVHGERMINRTFEPGFKIALHQKDLNLALQSAKALALNLPNTATCQELFNTCAANGGSQLDHSAM......................................................................................................................................................................................... 282
17 -58.4003pdu_A mol:protein length:287 3-hydroxyisobutyrate dehydrogenase family protein  ali model follow..  18  2....TTYGFLGLGIMGGPMAANLVRAGFDVTVWNRNPAKCAPLVALGAR-----QASSPAEVCAACDITIAMLADPAAAREVCFGANGVLEGIGGGRGYIDMSTVDDETSTAIGAAVTARGGRFLEAPVSGTKKPAEDGLIILAAGDQSLFTDAGPAFAALGKK-------CLHLGEVGQGARMKLVVNMIMGQMMTALGEGMALGRNCGLDG----GQLLEVLDAGAMANPMFKGKGQMLLSGEFPTSFPLKHMQKDLRLAVELGDRLGQPLHGAATANESFKRARAAGHADEDFAAV......................................................................................................................................................................................... 281
18 -58.1004dll_A mol:protein length:320 2-hydroxy-3-oxopropionate reductase  ali model follow..  14  23.PYARKITFLGTGSMGLPMARRLCEAGYALQVWNRTPARAASLAALGAT-----IHEQARAAARDADIVVSMLENGAVVQDVLFA-QGVAAAMKPGSLFLDMASITPREARDHAARLGALGIAHLDTPVSGGTVGAEQGLVIMAGGKPADFERSLPLLKVFGR--------ATHVGPHGSGQLTKLANQMIVGITIGAVAEALLFATKGGADM----AKVKEAITGGFADSRVLQLHGQRMVERDFAPRARLSIQLKDMRNALATAQEIGFDAPITGLFEQLYAEGVEHGLTDLDQSGL......................................................................................................................................................................................... 303
19 -58.0002uyy_A mol:protein length:316 N-PAC PROTEIN  ali model follow..  16  22.PTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGAR-----LGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGLVILAAGDRGLYEDCSSCFQAMGKT-------SFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQ----QTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAV......................................................................................................................................................................................... 304
20 -57.9003doj_A mol:protein length:310 Dehydrogenase-like protein  ali model follow..  18  13.SHMMEVGFLGLGIMGKAMSMNLLKNGFKVTVWNRTLSKCDELVEHGAS-----VCESPAEVIKKCKYTIAMLSDPCAALSVVFDKGGVLEQICEGKGYIDMSTVDAETSLKINEAITGKGGRFVEGPVSGSKKPAEDGLIILAAGDKALFEESIPAFDVLGKR-------SFYLGQVGNGAKMKLIVNMIMGSMMNAFSEGLVLADKSGLSS----DTLLDILDLGAMTNPMFKGKGPSMNKSSYPPAFPLKHQQKDMRLALALGDENAVSMPVAAAANEAFKKARSLGLGDLDFSAV......................................................................................................................................................................................... 295
21 -57.6002i9p_A mol:protein length:319 3-hydroxyisobutyrate dehydrogenase  ali model follow..  16  13YFQSMPVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQ-----VVSSPADVAEKADRIITMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGLTFMVGGVEDEFAAAQELLGCMGSN-------VVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDP----KLLAKILNMSSGRCWSSDTYNPVPSANNYQGGFGTTLMAKDLGLAQDSATSTKSPILLGSLAHQIYRMMCAKGYSKKDFSSV......................................................................................................................................................................................... 303
22 -57.5003obb_A mol:protein length:300 Probable 3-hydroxyisobutyrate dehydrogenase  ali model follow..  17  1.GHMKQIAFIGLGHMGAPMATNLLKAGYLLNVFDLVQSAVDGLVAAGAS-----AARSARDAVQGADVVISMLPASQHVEGLYLDDDGLLAHIAPGTLVLECSTIAPTSARKIHAAARERGLAMLDAPVSGGTAGAAAGLTFMVGGDAEALEKARPLFEAMGRN-------IFHAGPDGAGQVAKVCNNQLLAVLMIGTAEAMALGVANGLEA----KVLAEIMRRSSGGNWALEVYNPWPASRDYSGGFMAQLMAKDLGLAQEAAQASASSTPMGSLALSLYRLLLKQGYAERDFSVV......................................................................................................................................................................................... 290
23 -57.1005u5g_A mol:protein length:295 6-phosphogluconate dehydrogenase  ali model follow..  19  1..MNRVVGFIGLGRMGQAICRRLLASQMPVHVHNRSREKADDLIRQGAV-----WAPDIVALTRAARVLFVCTAGSEAVQDFYHAPDGLLACLEVGDIVVDLSTIAPETAEGLHAAFAQQGADYIECPVSGGVEGALAGLSAIVSGRPEAYGLIRPLLEVFCAT-------VTYVPEPGKAQRLKILNNLAESINLAGAIEVISQGLSQGLDL----KSMADVFTSCRGRSAYMDVALGYALSGGASSNVSLGVRCKDLELARRRL-PQDQSYPFSTLAMTTFDTVRQACGEESDQCQY......................................................................................................................................................................................... 282
24 -56.8003g0o_A mol:protein length:303 3-hydroxyisobutyrate dehydrogenase  ali model follow..  15  5.GTDFHVGIVGLGSMGMGAARSCLRAGLSTWGADLNPQACANLLAEGA----CGAAASAREFAGVVDALVILVVNAAQVRQVLFGEDGVAHLMKPGSAVMVSSTISSADAQEIAAALTALNLNMLDAPVSGGAVKAAQGMTVMASGSEAAFTRLKPVLDAVASN-------VYRISDTGAGSTVKIIHQLLAGVHIAAAAEAMALAARAGIPL----DVMYDVVTHAAGNSWMFENRMQHVVDGDYTPRSAVDIFVKDLGLVADTAKALRFPLPLASTALNMFTSASNAGYGKEDDSAV......................................................................................................................................................................................... 289
25 -56.7005je8_A mol:protein length:302 3-hydroxyisobutyrate dehydrogenase  ali model follow..  17  4KDPMKKIGFIGLGNMGLPMSKNLVKSGYTVYGVDLNKEAEASFEKEGGI-----IGLSISKLAETCDVVFTSLPSPRAVEAVYFGAEGLFENGHSNVVFIDTSTVSPQLNKQLEEAAKEKKVDFLAAPVSGGVIGAENRLTFMVGGSKDVYEKTESIMGVLGAN-------IFHVSEQDSGTTVKLINNLLIGFYTAGVSEALTLAKKNNMDL----DKMFDILNVSYGQSRIYERNYKFIAPENYEPGFTVNLLKKDLGFAVDLAKESELHLPVSEMLLNVYDEASQAGYGENDMAAL......................................................................................................................................................................................... 289
26 -54.1003qha_A mol:protein length:296 Putative oxidoreductase  ali model follow..  18  13.TEQLKLGYIGLGNMGAPMATRMTEWPGGVTVYDIRIEAMTPLAEAGAT-----LADSVADVAAA-----LIHITVLDDAQVREVVGELAGHAKPGTVIAIHSTISDTTAVELARDLKARDIHIVDAPVSGGAAAAARGLATMVGADREVYERIKPAFKHWAAV-------VIHAGEPGAGTRMKLARNMLTFTSYAAACEAMKLAEAAGLDL----QALGRVVRHTDALTGGPGAIMVRDNMKDLEPLHTRGLGEKDLSLALALGEAVSVDLPLARLAYEGLAAGLGVPHKEKE............................................................................................................................................................................................. 295
27 -54.1005y8g_A mol:protein length:295 Probable 3-hydroxyisobutyrate dehydrogenase  ali model follow..  15  1..MMTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVA-----VFRSAPEAVAEADVVITMLPTGEVVRRC---YTDVLAAARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAALAFMVGGDESTLRRARPVLEPMAGK-------IIHCGAAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLGLSA----QSLFDVITGATGNCWAVHTNCPVPANNDFKPGFSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKFAA.................................................................................................................................................................................................... 275
28 -52.7004gbj_A mol:protein length:297 6-phosphogluconate dehydrogenase NAD-binding  ali model follow..  14  2NAMSEKIAFLGLGNLGTPIAEILLEAGYELVVWNRTASKAEPLTKLGAT-----VVENAIDAITPGGIVFSVLADDAAVEELFSM--ELVEKLGKDGVHVSMSTISPETSRQLAQVHEWYGAHYVGAPIFARPEAVRAKGNICLSGNAGAKERIKPIVENFVKG-------VFDFGDDGAANVIKLAGNFMIACSLEMMGEAFTMAEKNGISR----QSIYEMLTSTLFAAPIFQNYGKLVASNTYEPAFRFPLGLKDINLTLQTASDVNAPMPFADIIRNRFISGLAKGRENLDWGAL......................................................................................................................................................................................... 285
29 -50.6001wp4_A mol:protein length:289 3-hydroxyisobutyrate dehydrogenase  ali model follow..  18  2....EKVAFIGLGAMGYPMAGHLARRFPTLVWNRTFEKALRHQEEFGS-------EAVPLERVAEARVIFTCLPTTREVYEV---AEALYPYLREGTYWVDATSGEPEASRRLAERLREKGVTYLDAPVSGGTSGAEAGLTVMLGGPEEAVERVRPFLA-YAKK-------VVHVGPVGAGHAVKAINNALLAVNLWAAGEGLLALVKQGVSA----EKALEVINASSGRSNATENLIPRVLTRAFPKTFALGLLVKDLGIAMGVLDGEKAPSPLLRLAREVYEMAKRELGPDADHVEA......................................................................................................................................................................................... 276
30 -47.4004d3s_A mol:protein length:293 IMINE REDUCTASE  ali model follow..  13  6.AKKSPVTLIGLGPMGQAMAGALLEAGYELTVWNRTKAKAEALAERGAA-----VADSPAEALRAGGPVLLSLTEHAVMYRVLEGAESDL----KGRTILNLGSDTPAASRAAAAWAEGHGARYVTGGVMSPAPGIGSSVFSFYSGDRAAFEENKALLEVLTATDF-------RGEDPGLAQVYYQILLDLFWTTMTGYLHALAVARAEGVP----VGTITPYLIEGNDMAMFFEGTSAAVAEGRFGDEDRISMDAASMEHVVQTSRDAGVDTALPEAVLSLFRRGLDAGFAESSFARL......................................................................................................................................................................................... 285
31 -47.0005a9r_A mol:protein length:290 IMINE REDUCTASE  ali model follow..  12  3.DQNLPVTVAGLGPMGSALAAALLDRGHDVTVWNRSPGKAAPLVAKGAR-----QADDIVDAVSASRLLVVCLADYDALYSALGPAREAL----RGRVVVNLNSGTPKEANEALRWAERHGTGYLDGAIMVPPAMVGHPSVFLYSGSAEVFEEYKETLAGLGDP-------VHLGTEAGLAVLYNTALLSMMYSSMNGFLHAAALVGSAGVPAAEFTKLAVDWFLPAVIGQIIKAEAPTIDEGVYPGDAGSLEMNVTTLKHIIGTSQEQGVDTEIPVRNKELLDRAVAAGFGESSYYSV......................................................................................................................................................................................... 285
32 -47.0004oqz_A mol:protein length:289 Putative oxidoreductase YfjR  ali model follow..  16  1..MSQSVTVIGLGPMGQAMAAAYLDRGYEVTLWNRTASRADALVARGAK-----LAATPEQALSANELVILSLIDYDAMYGVLEGAEEAV----AGRVLVNLSSDTPEKARAAARRVAELGGTHLTGGVLSPPPGIGSPMSTFYSGPRAAYDQHRAALEVITGK-------TDYRGEDGLAALMYQLNMVVFWPAMLSYWQAVALADAHGLTAADIAPYVSENFAG---MGQFIDFYAARIDAGNHAGDDRLSMGVASMEHVVHTNADSGVDTAFPRAVLDAFHRGADAGFGADSFSSV......................................................................................................................................................................................... 281
33 -46.6004oqy_A mol:protein length:290 (S)-imine reductase  ali model follow..  14  1MS-KQSVTVIGLGPMGQAMVNTFLDNGHEVTVWNRTASKAEALVARGAV-----LAPTVEDALSANELIVLSLTDYDAVYAILEPVTGSL----SGKVIANLSSDTPDKAREAAKWAAKHGAKHLTGGVQVPPPLIGKPSSTYYSGPKDVFDAHEDTLKVLTNADY-------RGEDAGLAAMYYQAQMTIFWTTMLSYYQTLALGQANGVSAKELLPYA----MMTSMMPHFLELYAQHVDSADYPGDVDLAMGAASVDHVLHTHQDAGVSTVLPAAVAEIFKAGMEKGFAENSFSSL......................................................................................................................................................................................... 281
34 -46.3005ocm_A mol:protein length:291 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase  ali model follow..  13  1MRDT-DVTVLGLGLMGQALAGAFLKDGHATTVWNRSEGKAGQLAEQGAV-----LASSARDAAEASPLVVVCVSDHAAVRAVLDPLGDVL----AGRVLVNLTSGTSEQARATAEWAAERGITYLDGAIMAIPQVVGTAAFLLYSGPEAAYEAHEPTLRSLGAG-------TTYLGDHGLSSLYDVALLGIMWGTLNSFLHGAALLGTAKVEATTFAPFANRWIE---AVTGFVSAYAGQVDQGAYPLDATIDTHVATVDHLIHESEAAGVNTELPRLVRTLADRALAGGQGGLGYAAM......................................................................................................................................................................................... 282
35 -46.1004d3d_A mol:protein length:310 IMINE REDUCTASE  ali model follow..  13  18VGNRKSVTVIGLGPMGQAMADVFLEYGYSVTVWNRTSSKADQLVAKGAI-----RVSTVNEALAANELVILSLTDYNVMYSIL----EPVSENLFGKVLVNLSSDTPEKARKAAKWLEDRGARHITGGVQVPPSGIGKSSYTYYSGDRVVFEAHRETLEVLTSSDY-------RGEDPGLAMLYYQIQMDIFWTAMLSYLHALAIANANGITAEQFLPYASAMMSSLPK---FVEFYTPRLDEGEHPGDVDLAMGLASVEHVVHTTQEAGIDIALPATVLEVFRRGMKTGHASDSFTSL......................................................................................................................................................................................... 299
36 -46.1003zgy_A mol:protein length:309 R-IMINE REDUCTASE  ali model follow..  11  16QAEHTPVTVIGLGLMGQALAGAFLGAGHPTTVWNRTAAKAEPLVARGAK-----SAGSVAEAVAASPLVVVCVSDYDAVHAL---LDPLDGTALQGRTLVNLTSGTSAQARERAAWADGRGADYLDGAILAGPAAIGTAAVVLLSGPRSAFDPHASALGGLGAG-------TTYLGADGLASLYDAAGLVMMWSILNGFLQGAALLGTAGVDATTFAPFITQGIGTVAD---WLPGYARQIDDGAYPDDAAIDTHLATMEHLIHESEFLGVNAELPRFIKALADRAVADGHGGSGYPAL......................................................................................................................................................................................... 299
37 -45.8003l6d_A mol:protein length:306 Putative oxidoreductase  ali model follow..  12  7.SFEFDVSVIGLGAMGTIMAQVLLKQGKRVAIWNRSPGKAAALVAAGAH-----LCESVKAALSASPATIFVLLDNHATHEV-LGMPGVARAL-AHRTIVDYTTNAQDEGLALQGLVNQAGGHYVKGMIVAYPRNVGHRSHSIHTGDREAFEQHRALLEGLAGH-------TVFLPW-DEALAFATVLHAHAFAAMVTFFEAVGAGDRFGLPVSKTARLLLE--TSRFFVADALEEAVRRLETQDFKDQARLDVHADAFAHIAQSLHAQGVWTPVFDAVCQVVQRAAAMGYGDQDIAAT......................................................................................................................................................................................... 289
38 -45.3005g6r_A mol:protein length:295 IMINE REDUCTASE  ali model follow..  13  1..MSKHIGIFGLGAMGTALAAKYLEHGYKTSVWNRTTAKAIPLVEQGAK-----LASTISEGVNANDLIIICLLNNQVVEDALRDALQTL----PSKTIVNLTNGTPNQARKLADFVTSHGARYIHGGIMAVPTMIGSPAVLLYSGESLEFQSIESHLSLLGMSKY-------LGTDAGSASLHDLALLSGMYGLFSGFLHAVALIKSGQDTSTTATGLLPLLTPWLSAMTGYLSSIAKQIDDGDYATGSNLGMQLAGVENIIRAGEEQRVSSQMILPIKALIEQAVGEGHGGEDLSAL......................................................................................................................................................................................... 284
39 -42.8005ojl_A mol:protein length:298 Imine reductase  ali model follow..  13  5.TTTTKLTIFGLGAMGTAMATQFLKQGHTPTVWNRTAAKANPLVEQGAH-----LAATIPAAIAASPLLIFCLLDNAAVEQTLAAGPPSL----AGKTILNLTNGTPSQARRLATLASARGARYFHGGIMADMIGAPHAILYSGGGSAETYASVEGVLAVLGSGKY-------LGDDAGSASLHDLALLSGMYGLFAGFATALVRSEGEGVSATEFLGLLAPWLQ---AMTGYLGLLARQIDDGVYTATSNLEMQLVALENACAASREQGVSAEVMLPLKGLVERAVREGRGGHDISSL......................................................................................................................................................................................... 289
40 -32.4001i36_A mol:protein length:264 CONSERVED HYPOTHETICAL PROTEIN MTH1747  ali model follow..  12  1....LRVGFIGFGEVAQTLASRLRSRGVEVVTSLEGRSPSTIERARTVG-----VTETSEEDVYSCPVVISAVTPGVALGAARRAGRHV------RGIYVDINNISPETVRMASSLIEKGG--FVDAAIMGSVRRKGADRIIASGRDAEEFMKLNRYGLNI----------EVRGREPGDASAIKMLRSSYTKGVSALLWETLTAAHRLGLE-----EDVLEMLEYTEGND--FRESAISRLKSSCIHAR---RRYEEMKEVQDMLAEVIDPVMPTCIIRIFDKLKDVKVSADARLQGCA........................................................................................................................................................................................ 264
41 -31.8004ezb_A mol:protein length:317 uncharacterized conserved protein  ali model follow..  11  15QSMMTTIAFIGFGEAAQSIAGGLGGRNAALAAYDASGALRARAAELGVE------PLDDVAGIACADVVLSLVVGAATKAVA----ASAAPHLSDEAVFIDLNSVGPDTKALAAGAIATGKGSFVEGAVMARVPPYAEKVPILVAGRRA--VEVAERLNALGMNLEA--------ETPGQASSLKMIRSVMIKGVEALLIEALSSAERAGVTE-RILDSVQETFPGLDWRD-----VADYYLSRTFEHGA---RRVTEMTEAAETIESFGLNAPMSRAACETIAAAHAAMKDQ............................................................................................................................................................................................... 288
42 -29.2003qsg_A mol:protein length:312 NAD-binding phosphogluconate dehydrogenase-like protein  ali model follow..  11  15QSNAMKLGFIGFGEAASAIASGLRQAGIDMAAYDAASAES---WRPRAEELGVSCKASVAEVAGECDVIFSLVTAQAALEVA----QQAGPHLCEGALYADFTSCSPAVKRAIGDVISRHRPSAQYAAVAVMSAVKPHGRVPLVVDGDGARRFQAAFTLYGCRIEVLD-------GEVGGAALLKMCRSAVLKGLEALFLEALAAAEKMGLADRVLASLD------ASFPEHHLRDLALYLVERNLEHAD---RRAHELGEVAATLCSVGVEPLVAEAGYRRLTRVAQVRAALKQRP........................................................................................................................................................................................... 290
43 -26.9004ypo_A mol:protein length:333 Ketol-acid reductoisomerase  ali model follow..  13  13..QGRKVGVIGYGSQGHAHSLSLRDSGVQVRVGLKQGSRSRPKVEEQG-----LDVDTPAEVAKWADV---VMVLAPDTAQAEIFAGDIEPNLKPGDALFFGHGLNVHFGLIKPPADVAVAMVAPKGPGHLVRRQFVDGVAVEQDPRGDGLALALSYAKAIGGTR-------AGVIKTTFKDETETEQTVLCGGTEELVKAGFEVMVEAGYPAELAYFEVLHELK................................................................................................................................................................................................................................................................... 230
44 -24.6004xiy_A mol:protein length:338 Ketol-acid reductoisomerase  ali model follow..  13  15..QSKKVAIIGYGSQGHAHACNLKDSGVDVYVGLRAGSASVAKAEAHG-----LTVKSVKDAVAAADV---VMILTPDEFQGRLYKDEIEPNLKKGATLAFAHGFSIHYNQVVPRADLDVIMIAPKAPGHTVRSEFVRGGGILIAVYQDASGNAKNLALSYACGVGGGRTGIIETTKDETETDLFGEQAVLCGGCVELVKAGFETLVEAGYAPEMAYFECLHELK................................................................................................................................................................................................................................................................... 232
45 -22.5004yte_A mol:protein length:194 H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ0715  ali model follow..  10  15LEQLKVPEKFGGEPPYGGMAIEFAKAGHDVVLSEPNRDVMSDDLWKKVEDAGVKVVSDDIEAAKHGEI---HVLFTPFGRITLNIANTIIEHVPENAIICNTCTIPTPVLYRSLEGILRRDVGISSMHPTGVPGTPSQKYYTIAGATEDQINKLVELVKSVGKIP............................................................................................................................................................................................................................................................................................................................... 189
46 -22.3002yjz_A mol:protein length:201 METALLOREDUCTASE STEAP4  ali model follow..  14  16SEKQGVVCIFGTGDFGKSLGLKMLQCGYSVVFGSRNPQVSSLLPRGAE-------VLCYSEAASRSDVIVLAVHREHYDFLAELADS-------KGRVLIDVSNYPESNAEYLAQLVPGKAFNTISAWALQSGTLDASRQVFVCGNDSKAKDRVMDIARTLGLTPLD-------QGSLVAAKEIE........................................................................................................................................................................................................................................................................................................... 190
47 -22.2004kqw_A mol:protein length:350 Ketol-acid reductoisomerase  ali model follow..  14  26..QGLKVGIIGYGSQGHAHALNLMDSGVDVRVGLREGSSSWKTAEEAG-----LKVTDMDTAAEEADV---IMVLVPDEIQPKVYQEHIAAHLKAGNTLAFAHGFNIHYGYIVPPEDVNVIMCAPKGPGHIVRRQFTEGACVQQDATGNAWDIVLSYCWGVGGARSGIIKATF---AEETEEDLFGEQAVLCGGLVELVKAGFETLTEAGYPPELAYFECYHEMK................................................................................................................................................................................................................................................................... 243
48 -22.1001np3_A mol:protein length:338 Ketol-acid reductoisomerase  ali model follow..  11  15..QGKKVAIIGYGSQGHAHACNLKDSGVDVTVGLRSGSATVAKAEAHG-----LKVADVKTAVAAADV---VMILTPDEFQGRLYKEEIEPNLKKGATLAFAHGFSIHYNQVVPRADLDVIMIAPKAPGHTVRSEFVKGIAIYQDASGNAKNVALSYACGVGGGR---TGIIETTFKDETETDLFGEQAVLCGGCVELVKAGFETLVEAGYAPEMAYFECLHELK................................................................................................................................................................................................................................................................... 232
49 -21.6005t57_A mol:protein length:296 Semialdehyde dehydrogenase NAD-binding protein  ali model follow..  10  14.HMKEKIALFGAGKMGVRLAKNLLKSDYRVSHVEVSEVGKKRLKDELG-----LECVSTEAALDNVDVVILAVPD----TIIGKIAAQIAPQLRPGTMVMTLDAAAPFAGHLPDRPDLTYFVAHPCHPLIFNDETDPEATSALMQGPEEAFDLGEAVAKVIYAPILR----SYRLTVDQMALLEPGLSETICATLLQVMREAMDETVRRGVPKEAARDFLLGHMNI.................................................................................................................................................................................................................................................................. 240
50 -21.5004yt4_A mol:protein length:375 H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338  ali model follow..  9  26INKLNLPEKFGGEPPYGGMAIEFAEAGHDVVLAEPNKNIMSDDLWKKVEDAGVKVVSDDVEAAKHGEI---HVLFTPFGKATFRIAKTIIEHVPENAVICNTCTVSPVVLYYSLEPILRKDVGISSMHPAAVPGTPQHGHYVIGGKTEEQIKKAVELAKSAGKE-------AYVVPADVSSVVADMG-SLVTAVALSGVLDYYTVGRKIINAPKKMIEQQVI...................................................................................................................................................................................................................................................................... 249
51 -20.9005yeq_A mol:protein length:340 Ketol-acid reductoisomerase (NADP(+))  ali model follow..  15  14VIKEKRVAVLGYGSQGRAWALNLRDSGIKVSVGLEREGNSWKQAENDG-----FKPLRTEEAVRNSDI---IIFLLPDMIQRTVYLERVKPYLKEGMDLVFAHGFNIHYRLIEPPSNVDVYMIAPKAPGPIVREYFAKGVATYQDHSGKALQKALAVAKAIGAT-------RAGVIETTFKEETETEQVDLVGGVMQLMRYAFQTLVEAGYQPEVAYFETINEMK................................................................................................................................................................................................................................................................... 233
52 -20.5002vns_A mol:protein length:215 METALLOREDUCTASE STEAP3  ali model follow..  15  26.DEAPKVGILGSGDFARSLATRLVGSGFKVVVGSRNPKRTARLFPSAAQ------VTFQEEAVSSPEVIFVAVFREHYSSLCSLSDQ-------AGKILVDVSNPTEQEHLQHRESNAEKAFNVISAWTLQAGPRDGNRQVPICGDQPEAKRAVSEMALAMGFMPVD-------MGSLASAWEVEAMPLRL..................................................................................................................................................................................................................................................................................................... 208
53 -19.3005e4r_A mol:protein length:490 Ketol-acid reductoisomerase  ali model follow..  11  14PIKNKTIAILGYGSQGRAWALNLRDSGLNVVVGLERQGDSWRRAIDDG-----FKPMYTKDAVAIADI---IVFLVPDMVQKSLWLNSVKDFMKKGADLVFAHGFNIHFKIIEPPKDSDVYMIAPKSPGPIVRRSYEMGVAVYQNVSGEALQKALAIAKGIGCA-------RAGVIESTFKEETETEQVILVGGIMELIKASFETLVEEGYQPEVAYFETVNELKLEKGLTGMLRAVSDTAKYGGITVGKFIDKMKIVLERIRSGEFAREWIKEYERGMPTVFKELSELEGSTIETVGRKLREMMFRGMKQISSHETDLFG--EQVILVGGIMELIKSFETLVEEGYQ-------PEVA----------------YFETVNELKLIVDLIYEKGLTGMLRAVSDTAKYGGITVGKFIIDKSVRDKMKIVLERIRSGEFAREWVFKELSELEGSTIETVGRK....................... 467
54 -17.8004xdz_A mol:protein length:343 Ketol-acid reductoisomerase  ali model follow..  16  18....KTIAILGYGSQGRAWALNLRDSGLNVVVGLERQGDSWRRAIDDG-----FKPMYTKDAVAIADI---IVFLVPDMVQKSLWLNSVKDFMKKGADLVFAHGFNPKDSDVYMIAPKSPGPIVRRSYEMGG--GVPALVAVYQNVSGEALQKALAIAKGIGCA-------RAGVIESTFKEETETEQVILVGGIMELIKASFETLVEEGYQPEVAYFETVNELK................................................................................................................................................................................................................................................................... 233
55 -17.7003c24_A mol:protein length:286 Putative oxidoreductase  ali model follow..  9  12....KTVAILGAGKMGARITRKIHDSAHHLAAIEIAPEGRDRLQGMGIP------LTDGDGWIDEADVVVLALPD----NIIEKVAEDIVPRVRPGTIVLILDAAAPYAGVMPE---RADITYFIGHPCHPPLFNDETDVCALMQGPEEHYAIGADICETMWSPVTR----THRVTTEQLAILEPGLSEMVAMPFVETMVHAVDECADRYGIDRQAALDFMI...................................................................................................................................................................................................................................................................... 229
56 -16.7004xdy_A mol:protein length:338 Ketol-acid reductoisomerase  ali model follow..  11  13ILRDKTIAVMGYGAQGDAQANCLKDSGINVVIGETEILGGNKNPSWEKAKEDGFEVLPIDKAAEKGDV---VHILLPDEVQPAIYENQIKPQLKAGKALCFSHGFNICFKRIVPPEDVDVIMVAPKAPGTEERKAYLEGVAVKQNPSGEAREVALAMTKAMHWTK-------AGILECTFEQETYEEQCVLCGGLVELMRNGFEVLVEAGYPPEMAYFECVHEMK................................................................................................................................................................................................................................................................... 237
57 -15.9001jax_A mol:protein length:212 conserved hypothetical protein  ali model follow..  14  1....MRVALLGTGNLGKGLALRLATLGHEIVVGSRREEKAEAKAAERIAGDASITGMKNEDAAEACDIAVLTIPWEHAIDTARDLKNIL-----REKIVVSPLVSERSAAEIVAEVLESSALHTIPAARFANLDEKFDWDVPVCGDDDESKKVVMSLISEIDG--------PLDAGPLSNSRLVE........................................................................................................................................................................................................................................................................................................... 189
58 -15.5005n2i_A mol:protein length:232 Reduced coenzyme F420:NADP oxidoreductase  ali model follow..  14  17.VSGLSIAVLGTGDQGRGLARRFAMAGHEVILGSRSAERAQAVAAELGEGLPVRGM-DNAGAAEAGDVVIVAVPWDGHRALLESLKDVL-----AGKIVVDCVNEEGSAAEQAAAILPDAAFHHVSAVLLLDPEVEKVDLDVLVGDDREATDVVRALAARIPG--------GVYGGRLRNAHQVE........................................................................................................................................................................................................................................................................................................... 208
59 -14.9003dtt_A mol:protein length:245 NADP oxidoreductase  ali model follow..  14  11.FQGMKIAVLGTGTVGRTMAGALADLGHEVTIGTRDPKATLARAEPDAMGAPPVHLAAFADVAAGAELVVNATEG----ASSIAALTAAGAENLAGKILVDIANNTDSLGEQIQRTFPEKTLNTMNASLDPGRAAGGDHSVFVSGNDAAAKAEVATLLKSLG---------VIDLGDITTARGAE........................................................................................................................................................................................................................................................................................................... 215
60 -14.9002raf_A mol:protein length:209 Putative Dinucleotide-Binding Oxidoreductase  ali model follow..  14  11.FQGMEITIFGKGNMGQAIGHNFEIAGHEVTYYGSKDQA-----------------------TTLGEIVIMAVPYPALAALAKQYATQL-----KGKIVVDITNADSSAAQELQQQLPDKAFNTTFAATSGQVNGKEPTTVLVAGNDDSAKQRFTRALADSPLEVKD-------AGKLKRARELE........................................................................................................................................................................................................................................................................................................... 178
61 -14.7004tsk_A mol:protein length:350 Ketol-acid reductoisomerase  ali model follow..  15  18....KRIAVIGYGSQGHAHAQNLRDSGFDVVIGLRPGSSWAKAEADGFR------VMAVGEAVEESDVIMILLPDERQPAVYE---REIRPYLTAGKALAFAHGFNPKDVDVFMVAPKGPGHLVRRVYEAG--GGVPALIAVHQDASGQAKDLALAYARGIGAGR-------AGILTTTFREETETEQAVLCGGLSALIKAGFETLVEAGYQPEIAYFECLHEMK................................................................................................................................................................................................................................................................... 232
62 -14.6005t95_A mol:protein length:271 Prephenate dehydrogenase 1  ali model follow..  12  7.SQSLKIGIVGFGNFGQFLAKTMIKQGHTLTATSRSDY-----SELCLQMGIHFFRDVSAFLTADIDV---IVLCTSILSLSEVVGSMPLTSLKRPTLFVDVLSVKEHPRELLLREL-PEDSDILCTPMFGPQTAKNTDHTFMYIRDEVICSNFIQIFATEGCKMVQMSC-----------AKSQFITHTIGRTLGEMDIQSTPIDTKGFETLVKLKETTMRD..................................................................................................................................................................................................................................................................... 222
63 -14.4004a7p_A mol:protein length:446 UDP-GLUCOSE DEHYDROGENASE  ali model follow..  13  2...SVRIAMIGTGYVGLVSGACFSDFGHEVVCVDKDARKIDALVASNVKAGRLSFTTDLAEGVKDADAVFIAVGTPADLSYVFAAAREIAENLTKPSVIVTKSTVPVGTGDEVERIIAEVAPN-SGAKVVSNPEFLREGAAIVVVGTED--EFARQVMREIYRPLSLNQSAPVLFTGRRTSELIKYAANAFLAVKITFINEIADLCEQVGADVQEVSRGILALMKTAADNETPLRIVEATVQVNDARKRAMGRKVIKAMGGDVRGKTVGILGLTFKPNTDDMRDAPSLSIIAALQDAGATVKA--------DPEGVEQASKMLTDVEFVENPYAAADGADALVIVTEWDAFALDLTRIKNSLKSPVLVDLR................................................................................................................. 416
64 -14.3002y0c_A mol:protein length:478 UDP-GLUCOSE DEHYDROGENASE  ali model follow..  13  2...SMNLTIIGSGSVGLVTGACLADIGHDVFCLDVDQAKIKEVIARNRSAGRLRFSTDIEAAVAHGDVQFIAVGTPADLQYVLAAARNIGRYMTGFKVIVDKSTVPVGTAERVRAAVAEELAKRQMFSVVSNPEFLKEGAAIVIGCDDVPGERARELMKKLYAPFNRNHERTLYMDVRSA-EFTKYAANAMLATRISFMNELANLADRFGADIEAVRRGIEALIRTADEHGQSLQILKAVSSVNATQKRVLADKIVARFGEDLTGRTFAIWGLAFKPNTDDMREAPSRELIAELLSRGARIAVAQEEARRVIALDLADHPSWLERLSFVDDEAQAARDADALVIVTEWKIFSPDFVALGRLWKTPVIFDGRNL............................................................................................................... 435
65 -14.1003gg2_A mol:protein length:450 Sugar dehydrogenase, UDP-glucose/GDP-mannose dehydrogenase family  ali model follow..  10  1..MSLDIAVVGIGYVGLVSATCFAELGANVRCIDTDRNKIEKMIARNVKAGRLRFGTEIEQAVPEADIIFIAVGTPADMSYVLDAARSIGRAMSRYILIVTKSTVPVGSYRLIRKAIQEELDKRIDFDIASNPEFLKEGNAVVVGVSDRARELITSLYKPMLLNNFR-----VLFMDIASAEMTKYAANAMLATRISFMNDVANLCERVGADVSMVRLGIKALIRTAEDNGYRMEVLEAVERVNEKQKSILFDKFSTYYKGNVQGRCVAIWGLSFKPGTDDMREAPSLVLIEKLLEVGCRVRVYDPVAMKEAQKRLGDKVEYTTDMYDA------VRGAEALFHVTEWKEFMPDWSALSQAMAASLVIDGR................................................................................................................. 419
66 -14.0004huj_A mol:protein length:220 Uncharacterized protein  ali model follow..  10  14FQSMTTYAIIGAGAIGSALAERFTAAQIPAIIANRGPASLSSVTDRFGA----SVKAVELKDALQADVVILAVPY-DSIADIVTQVSDW-----GGQIVVDASNAIDFPAFKPRDLGGRLSTEIVSELVPGAKKGTGSRVLFLSGNHSDANRQVAELISSLGFAPVD-------LGTLAASGPIQ........................................................................................................................................................................................................................................................................................................... 200
67 -13.9002f1k_A mol:protein length:279 prephenate dehydrogenase  ali model follow..  12  1....MKIGVVGLGLIGASLAGDLRRRGHYLIGVSRQQSTCEKAVERQLVDEAGQDLSLLQTA---------IIFLCTPIQLILPTLEKLIPHLSPTAIVTDVASVK----TAIAEPASQLWSGFIGGPMAGTAAGIDGAEENLFVNDPEQLACLRSVLEPLGVK-------IYLCTPADHDQAVAWISH------LPVMVSAALIQACAGEKDGDILKLAQNLASSGFRDTSRVGGGNPEL................................................................................................................................................................................................................................................... 225
68 -13.6004r16_A mol:protein length:418 418aa long hypothetical UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase  ali model follow..  12  1....MRIAVLGLGYIGLPTAIMFASSGYDVVGYDIRSEVIKKINSKEVLSLGKLKVTDRVEDLKGSNVFIICVQTPPDLSYLERAIRTVAEVMDRGALVIIESTIPPGTTEKMARLLENLT---VDFYVAHAPERVMPGRIIIGGVSEKAANLAEKLYRSFVKGR-------IFLTNATTAEMVKLMENTFRDVNIALANEFALLAHQYGVNVYEAIELA........................................................................................................................................................................................................................................................................ 239
69 -13.4003g79_A mol:protein length:478 NDP-N-acetyl-D-galactosaminuronic acid dehydrogenase  ali model follow..  10  16.GPIKKIGVLGMGYVGIPAAVLFADAPEKVLGFQRNSKSLEELIGKVVKAGKFECTPDFSRI-SELDAVTLAIQTPPDFSALIDGIRNVGKYLKPGMLVVLESTITPGTTEGMAKQILEEESGLEDFALAHAPERVMVGRLIVGGIDEASTKRAVELYSPVLTVG------QVIPMSATAAEVTKTAENTFRDLQIAAINQLALYCEAMGINVYDVRTGVDSLKGEGITRAVLWSIYVLARKVNDFMPAHMYNLTVAALERLGKKMDGSKVAMLGWAFIKDSDDARNTPSEPYRDLCLKAGASVMVHDPYVVNYPGVEISDNLEEVVR-------ADAIVVLAGHSAYSSLKADWAKKVSAKANPVIIDGR................................................................................................................. 450
70 -13.3004xr9_A mol:protein length:456 CalS8  ali model follow..  13  13.PSPLKVVIAGAGYVGTCLAVTLAGRGAEVVAVDSDPGTVADLRARDLAATGRLTASTSYDPVGAADVVIVTVGTPMVTDQLVAACEQIAPRLRAGQLVILKSTVSPGTTRTLVAPLLESG----DFGLAFCPERLAEGVAVVGGCGPRSAAAAERFWRSALGVD------VRQVPSAESAEVVKLATNWWIDANVAIANELARYCAVLGVDVLDVIGAAWMAWRDGRDRGVSLRTVETARAVNDDMPRHTAAVIADELVKLGRDRNDTTIAV-LGAAFKNDTGDVRNTPVRGVVAALRDSGFRVRIFDPLADPAEIVARFGTAPAASLDEAVSGAGCLAFLAGHRQ----ELDFGALAERVDEPCLV.................................................................................................................... 429
71 -13.3003vtf_A mol:protein length:444 UDP-glucose 6-dehydrogenase  ali model follow..  17  13.SHMASLSVLGLGYVGVVHAVGFALLGHRVVGYDVNPSIVEEALGRALSSGRLSFAESAEEAVAATDATFIAVGTPADLRYVEAAARAVGRGIRAKGLVVVKSTVPPGTTEGLVARAVAEEAGGVKFSVASNPEFLREGSALIVIGDERAASFLLDVYKAVDAPK--------LVMKPREAELVKYASNVFLALKISFANEVGLLAKRLGVDTYRVFEAV........................................................................................................................................................................................................................................................................ 257
72 -13.1005vr8_A mol:protein length:495 UDP-glucose 6-dehydrogenase  ali model follow..  11  2MFEIKKICCIGAGYVGGPTCSVIAHMCIRVTVVDVNESRINAWNSESCRGKNLFFSTNIDDAIKEADLVFISVNTPADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAVLIGGETPEGQRAVQALCAVYEHWVPREKILT---NTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAILVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSEDDQVSRLVTISKDPYEACDGAHA--EWDLDYERIHKKMLKPAFI.................................................................................................................... 439
73 -12.9003ojl_A mol:protein length:431 Cap5O  ali model follow..  12  3.GSGSKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIQEVYEEVLSSGKLKVSTTPEA----SDVFIIAVPTPCDISLVMRALDSILPFLKKGNTIIVESTIAPKTMDDFVKPVIENL----DIYLVHCPERVLPGKIIIGGVTKACIEAGKRVYRTFVQGE-------MIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMA........................................................................................................................................................................................................................................................................ 244
74 -12.8001mfz_A mol:protein length:436 GDP-mannose 6-dehydrogenase  ali model follow..  10  1....MRISIFGLGYVGAVCAGCLSARGHEVIGVDVSSTKIEALLQQGRQTGRLSGTTDFKKAVLDSDVSFICVGTPLDLGYIETVCREIGFAIREKSTVVVRSTVLPGTVNNVVIPLIEDCSGKVDFGVGTNPEFLRESTATVIGEDKQTGDLLEEIYRELDAPIIRKTV---------VAEMIKYTCNVWHAAKVTFANEIGNIAKAVGVDGREVMDVICQDHKLNLSRYYM-----------RPGFAFGGSCLPKDVRALTYRASQLDVEHPMLGSLMRSNSNQVQKAFDL--------------------------ITSHDTRKVGLLGLSFKAGTDDLRESPL-------VELAEMLIGKGYELRIF-----------DRNVEYARVHGANKEYIESKIPHVSSLLVSDLDEVVAVLVLGNGDELFVDLVNKTPSGKKLVDLVGFMPHTTTAQ........................... 430
75 -12.6004ol9_A mol:protein length:304 Putative 2-dehydropantoate 2-reductase  ali model follow..  10  1MAMATGIALVGPGAVGTTVAALLHKAGYSPLLCGHTPRAGIELRRDGADVVPGPVHTSPREVAGPVD----VLILAVKATQNDAARPWLTRLCDERTVVAVLQNQVEQVQPHCPSSAVVPAIVWCSAETQPQGWVRLRGEAALVVPTGPAAEQFAGLLRGAGATVDCDPDFTTAA-------WRKLLVNALAGFMVRYVAECLAVARAEGADVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWDLRNGVIVRK-----------ARAHGLATPISDVLVPLLAAASDG................................................................................................................................................................................................... 296
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.