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Query: [M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase, from COG1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MIDVNTVVEKFKSRQALIGIVGLGYVGLPLMLRYNAIGFDVLGIDIDDVKVDKLNAGQCYIEHIPQAKIAKARASGFEATTDFSRVSECDALILCVPTPLNKYREPDMSFVINTTDALKPYLRVGQVVSLESTTYPGTTEEELLPRVQEGGLVVGRDIYLVYSPEREDPGNPNFETRTIPKVIGGHTPQCLEVGIALYEQAIDRVVPVSSTKAAEMTKLLENIHRAVNIGLVNEMKIVADRMGIDIFEVVDAAATKPFGFTPYYPGPGLGGHCIPIDPFYLTWKAREYGLHTRFIELSGEVNQAMPEYVLGKLMDGLNEAGRALKGSRVLVLGIAYKKNVDDMRESPSVEIMELIEAKGGMVAYSDPHVPVFPKMREHHFELSSEPLTAENLARFDAVVLATDHDKFDYELIKAEAKLVVDSRGKYRSPAAHIIKALast
1 -92.5004xr9_A mol:protein length:456 CalS8  ali model follow..  27  4...MPFLPDPGEPSPLKVVIAGAGYVGTCLAVTLAGRGAEVVAVDSDPGTVADLRAGRCRLPEPGLAGAVRAATGRLTASTSYDPVGAADVVIVTVGTPTDAGHEMVTDQLVAACEQIAPRLRAGQLVILKSTVSPGTTRTLVAPLLESGGLVHERDFGLAFCPERLAEGVALAQVRTLPVVVGGCGPRSAAAAERFWRSALGVVRQVPSAESAEVVKLATNWWIDANVAIANELARYCAVLGVDVLDVIGAANTLPKGVNLLLPGVGVGGSCLTKDPWMAWRDGRDRGVSLRTVETARAVNDDMPRHTAAVIADELVKLGRDRNDTTIAVLGAAFKNDTGDVRNTPVRGVVAALRDSGFRVRIFDPLADPAEIVARFG--TAPAASLDEAVSGAGCLAFLAGHRQFHELDFVDEPCLVFDGRMHLPPARIRELHR 446
2 -87.4003g79_A mol:protein length:478 NDP-N-acetyl-D-galactosaminuronic acid dehydrogenase  ali model follow..  28  5.MSKLEKLLKERGPIKKIGVLGMGYVGIPAAVLFADAPEKVLGFQRNSKKIEMLNRGESPLKEPGLEELIGVKAGKFECTPDFSRISELDAVTLAIQTPFAKDLEPDFSALIDGIRNVGKYLKPGMLVVLESTITPGTTEGMAKQILEESGLKAGEDFALAHAPERVMVGRLLKNIREHDRIVGGIDEASTKRAVELYSPVLTGQVIPMSATAAEVTKTAENTFRDLQIAAINQLALYCEAMGINVYDVRTGVDSEGITRAVLWPGAGVGGHCLTKDTYHLERGVKIGRGEDSIYVLARKVNDFMPAHMYNLTVAALERLGKKMDGSKVAMLGWAFIKDSDDARNTPSEPYRDLCLKAGASVMVHDPYVVNYP-------GVEISDNLEEVVRNADAIVVLAGHSAYSSLKAAKANPVIIDGRNVIEPDEFIG... 460
3 -85.9004r16_A mol:protein length:418 418aa long hypothetical UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase  ali model follow..  30  1...............MRIAVLGLGYIGLPTAIMFASSGYDVVGYDIRSEVIKKINSGVAHIIEPEIDRRLKLSLGKLKVTDRVEDLKGSNVFIICVQTPLS-GDDPDLSYLERAIRTVAEVMDRGALVIIESTIPPGTTEKMARLLENLTGLREGVDFYVAHAPERVMPGRIFKELVYNSRIIGGVSEKAANLAEKLYRSFVKGRIFLTNATTAEMVKLMENTFRDVNIALANEFALLAHQYGVNVYEAIELANTHP-RVKIHTPGIGVGGHCLPKDPYLLLSNAKE---DFGLIRIARRINERMPAFAAGLLFEALEKANIKPSEAIIAVLGLAYKGGTDDTRNSPALKFVEIIRNSVKEVRTYDPYVRGTH------------DSLEKVVEGADAIVIATDHPEFKSVNWSMRHKIIIDGRNIIKEPPV..... 406
4 -85.2003vtf_A mol:protein length:444 UDP-glucose 6-dehydrogenase  ali model follow..  25  1MGSSSSGLVPRGSHMASLSVLGLGYVGVVHAVGFALLGHRVVGYDVNPSIVERLRAGRPHIYEPGLEEALGLSSGRLSFAESAEAVAATDATFIAVGTPPAPDGSADLRYVEAAARAVGRGIRAKGLVVVKSTVPPGTTEGLVARAVAEEA--GGVKFSVASNPEFLREGSALEDFFKPDRIVIGAGDERAASFLLDVYKAVDAPKLVMKPREAELVKYASNVFLALKISFANEVGLLAKRLGVDTYRVFEAVGLDRIGRHYFGAGLGFGGSCFPKDTLAFIRFGESLGLEMAISKAVLRVNEYMPRYAVQLLEERL----GGLRGRHVGVLGLAFKPNTDDVRESRGVEVARLLLERGARVYVHDPMAMEKARAVL-GDSVTYVEDPQALLDQVEGVIIATAWPQYE--GLDYRGKVVVDGRYVKKAREAKIYEG 434
5 -84.9003ojl_A mol:protein length:431 Cap5O  ali model follow..  32  1..........MRGSGSKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQNGQISIEEPGLQEVYELSSGKLKVSTT---PEASDVFIIAVPTPNNDDQSCDISLVMRALDSILPFLKKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDIYLVHCPERVLPGKILEELVHNNRIIGGVTKACIEAGKRVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMANKHP-RVNIHQPGPGVGGHCLAVDPYFIIAKDPE---NAKLIQTGREINNSMPAYVVDTTKQII----KALSGNKVTVFGLTYKGDVDDIRESPAFDIYELLNQEDIEVCAYDPHVELD----------FVEHDMSHAVKDASLVLILSDHSEFKNLSDKMKHKVIFDTKNVVKSSFEDVL.. 412
6 -83.8002o3j_A mol:protein length:481 UDP-glucose 6-dehydrogenase  ali model follow..  19  1......MTDQVFGKVSKVVCVGAGYVGGPTCAMIAHKCPTVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAAGRNLFFSSDIKAIAEADLIFISVNTPTKMYGAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESQAVAELVRIYENWVRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPADYWQGVININNWQRRRFADKIIAEL---FNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLQDVERLITVESDPYAAARGAHAIVVLTEWDEFVELNDMQHPAAIFDGRLILDQKALREI.. 458
7 -83.3002y0c_A mol:protein length:478 UDP-GLUCOSE DEHYDROGENASE  ali model follow..  25  1.............GSMNLTIIGSGSVGLVTGACLADIGHDVFCLDVDQAKIDILNNGGVPIHEPGLKEVIARSAGRLRFSTDIAAVAHGDVQFIAVGTPPDEDGSADLQYVLAAARNIGRYMTGFKVIVDKSTVPVGTAERVRAAVAEEAKRGGDQMFSVVSNPEFLKEGAAVDDFTRPDRIVIGCDDVPGERARELMKKLYHERTLYMDVRSAEFTKYAANAMLATRISFMNELANLADRFGADIEAVRRGIGSDPIGYHFLYAGCGYGGSCFPKDVEALIRTADEHGQSLQILKAVSSVNATQKRVLADKIVARF---GEDLTGRTFAIWGLAFKPNTDDMREAPSRELIAELLSRGARIAAYDPVAQEEARRVIALDRLSFVDDEAQAARDADALVIVTEWKIFKSPDFLWKTPVIFDGRNLYEPETMSEQ.. 444
8 -82.9003gg2_A mol:protein length:450 Sugar dehydrogenase, UDP-glucose/GDP-mannose dehydrogenase family  ali model follow..  24  2..............SLDIAVVGIGYVGLVSATCFAELGANVRCIDTDRNKIEQLNSGTIPIYEPGLEKMIAVKAGRLRFGTEIQAVPEADIIFIAVGTPAGEDGSADMSYVLDAARSIGRAMSRYILIVTKSTVPVGSYRLIRKAIQEEDKREVLIDFDIASNPEFLKEGNAIDDFMKPDRVVVGVSDRARELITSLYKPMLLNRVLFMDIASAEMTKYAANAMLATRISFMNDVANLCERVGADVSMVRLGIGSDSIGSKFLYPGCGYGGSCFPKDVKALIRTAEDNGYRMEVLEAVERVNEKQKSILFDKFSTYY---KGNVQGRCVAIWGLSFKPGTDDMREAPSLVLIEKLLEVGCRVRVYDPVAMKEAQKRL-GDKVEYTTDMYDAVRGAEALFHVTEWKEFRMPDWAMAASLVIDGRNVYELPADSDFT. 431
9 -80.9001mfz_A mol:protein length:436 GDP-mannose 6-dehydrogenase  ali model follow..  23  1...............MRISIFGLGYVGAVCAGCLSARGHEVIGVDVSSTKIDLINQGKSPIVEPGLEALLQRQTGRLSGTTDFKAVLDSDVSFICVGTPSKKNGDLDLGYIETVCREIGFAIREKSTVVVRSTVLPGTVNNVVIPLIEDSGKKAGVDFGVGTNPEFLRESTAIKDYDFPPMTVIGLDKQTGDLLEEIYREL-DAPIIRKTVEVAEMIKYTCNVWHAAKVTFANEIGNIAKAVGVDGREVMDVICQDHLSRYYMRPGFAFGGSCLPKDVRALTYRASQLDVEHPMLGSLMRSNSNQVQKAFDLITS--------HDTRKVGLLGLSFKAGTDDLRESPLVELAEMLIGKGYELRIFDRNVEYARVSKIPHVSSLLVSDLDEVVASSDVLVLGNGDELFVDLVNTPSGKKLVDLVGFMPHTTTAQAEG 433
10 -80.9004a7p_A mol:protein length:446 UDP-GLUCOSE DEHYDROGENASE  ali model follow..  23  1.............GSVRIAMIGTGYVGLVSGACFSDFGHEVVCVDKDARKIELLHQNVMPIYEPGLDALVAVKAGRLSFTTDLEGVKDADAVFIAVGTPSRRDGHADLSYVFAAAREIAENLTKPSVIVTKSTVPVGTGDEVERIIAEVAP---NSGAKVVSNPEFLREGAAIEDFKRPDRVVVGTDEFARQVMREIYRPLSLNPVLFTGRRTSELIKYAANAFLAVKITFINEIADLCEQVGADVQEVSRGIGMDNIGGKFLHAGPGYGGSCFPKDTLALMKTAADNETPLRIVEATVQVNDARKRAMGRKVIKAM---GGDVRGKTVGILGLTFKPNTDDMRDAPSLSIIAALQDAGATVKAYDPEGVEQASKMLT--DVEFVENPYAAADGADALVIVTEWDAFRALDLSLKSPVLVDLRNIYPPAELERA.. 427
11 -80.4005vr8_A mol:protein length:495 UDP-glucose 6-dehydrogenase  ali model follow..  18  3............FEIKKICCIGAGYVGGPTCSVIAHMCPRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCGKNLFFSTNIDAIKEADLVFISVNTPTKTYGAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIF--DANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGETPEGQRAVQALCAVYEEKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPARYWQQVIDMNDYQRRRFASRIIDSL---FNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYMLKPAFIFDGRRVLDGLHNELQTI 456
12 -74.0003pid_A mol:protein length:432 UDP-glucose 6-dehydrogenase  ali model follow..  20  20....GGQQMGRGSEFMKITISGTGYVGLSNGVLIAQ-NHEVVALDIVQAKVDMLNQKISPIVDKEIQEYLAEKPLNFRATTDKDAYRNADYVIIATPTDYDPKTNYFNTSTVEAVIRDVTEINPNAVMIIKSTIPVGFTRDIKERL---------GIDNVIFSPEFLREGRALYDNLHPSRIVIGERSAAERFADLLKEGAIKQPTLFTDSTEAEAIKLFANTYLALRVAYFNELDSYAESQGLNSKQIIEGVCLDPIGNHYNNPSFGYGGYCLPKDTKQLLANYE--SVPNNIIAAIVDANRTRKDFIADSILA--------RKPKVVGVYRLIMKSGSDNFRASSIQGIMKRIKAKGIPVIIYEPVMQEDEFF-----NSRVVRDLNAFKQEADVIISNRMAEELADVADKVYTRDLFG............... 416
13 -74.0001dli_A mol:protein length:402 UDP-GLUCOSE DEHYDROGENASE  ali model follow..  18  1...............MKIAVAGSGYVGLSLGVLLSL-QNEVTIVDILPSKVDKINNGLSPIQDEYIEYYLK--SKQLSIKATLDKAAYKEAELVIIATPTNYNSRINYFDTQHVETVIKEVLSSHATLIIKSTIPIGFITEMRQKF---------QTDRIIFSPEFLRESKALYDNLYPSRIIVSCEENDSPKVKADAEKFANVPVLIMGASEAEAVKLFANTYLALRVAYFNELDTYAESRKLNSHMIIQGISYDDIGMHYNNPSFGYGGYCLPKDTKQLL--ANYNNIPQTLIEAIVSSNNVRKSYIAKQIINVLK--EQESPVKVVGVYRLIMKSNSDNFRESAIKDVIDILKSKDIKIIIYEPMLNKLESED----QSVLVNDLENFKKQANIIVTNRYDNELQDVKN------KVYSRDIFGRD....... 402
14 -23.1003qha_A mol:protein length:296 Putative oxidoreductase  ali model follow..  14  9........AAHTTEQLKLGYIGLGNMGAPMATRMTEWPGGVTVYDIRIEAMTPL------------------AEAGATLADSVADVAAADLIHITVLDD---------AQVREVVGELAGHAKPGTVIAIHSTISDTTAVELARDLKARD------DAPVSGGAAAAARGELA--------TMVGADREVYERIKPAFKHWAAVVIHAGEPGAGTRMKLARNMLTFTSYAAACEAMKLAEAAGLDLQALGRVVRHTDALTGGPYQPFLHTRGLGEKDLSLALALGEAVSVDLPLARLAYEG....................................................................................................................................... 282
15 -21.8005y8g_A mol:protein length:295 Probable 3-hydroxyisobutyrate dehydrogenase  ali model follow..  15  3...............TTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAA-----------------HGVAVFRSAPEAVAEADVVITMLPTG---------EVVRRCYTDVLAAARPATLFIDSSTISVTDAREVHALAESH-------GMLQLDAP----SGGVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLGLSLFDVITGATGNCWAVHTNCPKPGFSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKFAADHADLDFSAVIHTLRARADA............................................................................................................. 295
16 -21.7003w6u_A mol:protein length:306 6-phosphogluconate dehydrogenase, NAD-binding protein  ali model follow..  17  1.MGSSSSGLVPRGSHMRVGFIGLGIMGGPMATHLLKAGFLAAVYNRTREKTKPFAE-----------------AGVYVAESPADLAKRVDVVIVMVSDA------PDVEQVLFGPSGVVEGARPGLIVVDMSTNSPDWARKFAERLAQY-------GIEFLDAP----TGGQKGAIEGTLTIMVGGKEELFHRLLPIFKAMGRDIVYMGPVGYGQAMKLVNQVVVALNTVAMVEGLKLAKALGLDMDKVAEVLTRGAARSGAIE-SPGFKAEHLKKDLGYVLEEARKRGVKLPGAELAYEL....................................................................................................................................... 277
17 -21.6003cky_A mol:protein length:301 2-hydroxymethyl glutarate dehydrogenase  ali model follow..  14  2............EKSIKIGFIGLGAMGKPMAINLLKEGVTVYAFDLMEANVAAVVA-----------------QGAQACENNQKVAAASDIIFTSLPNA------GIVETVMNGPGGVLSACKAGTVIVDMSSVSPSSTLKMAKVAAEK-------GIDYVDAP----SGGTKGAEAGTLTIMVGASEAVFEKIQPVLSVIGKDIYHVGDTGAGDAVKIVNNLLLGCNMASLAEALVLGVKCGLKPETMQEIIGKSSGRSYAME-AGGFAMDLQHKDLGLALEAGKEGNVPLPMTAMATQI....................................................................................................................................... 268
18 -21.5003doj_A mol:protein length:310 Dehydrogenase-like protein  ali model follow..  14  1MGSSSSGLVPRGSHMMEVGFLGLGIMGKAMSMNLLKNGFKVTVWNRTLSKCDELVE-----------------HGASVCESPAEVIKKCKYTIAMLSDP------CAALSVVFDKGGVLEQICEGKGYIDMSTVDAETSLKINEAITGKGGRFV--EGPVSGSKKPAEDGQLI--------ILAAGDKALFEESIPAFDVLGKRSFYLGQVGNGAKMKLIVNMIMGSMMNAFSEGLVLADKSGLSSDTLLDILDLGAMTNPMFK-PPAFPLKHQQKDMRLALALGDENAVSMPVAAAANEA....................................................................................................................................... 278
19 -21.5003pef_A mol:protein length:287 6-phosphogluconate dehydrogenase, NAD-binding  ali model follow..  14  1..............SQKFGFIGLGIMGSAMAKNLVKAGCSVTIWNRSPEKAEELAA-----------------LGAERAATPCEVVESCPVTFAMLADP------AAAEEVCFGKHGVLEGIGEGRGYVDMSTVDPATSQRIGVAVVAKGGRFL--EAPVSGSKKPAEDGTLI--------ILAAGDRNLYDEAMPGFEKMGKKIIHLGDVGKGAEMKLVVNMVMGGMMACFCEGLALGEKAGLATDAILDVIGAGAMANPMFA-APAFPLKHMQKDLRLAVALGDRVGQPLVASAAANEL....................................................................................................................................... 264
20 -21.4002i9p_A mol:protein length:319 3-hydroxyisobutyrate dehydrogenase  ali model follow..  14  10........ENLYFQSMPVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQD-----------------AGEQVVSSPADVAEKADRIITMLPTS------INAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKM-------GAVFMDAP----SGGVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDLAKILNMSSGRCWSSDTYNPQGGFGTTLMAKDLGLAQDSATSTKSPILLGSLAHQI....................................................................................................................................... 286
21 -21.3001vpd_A mol:protein length:299 TARTRONATE SEMIALDEHYDE REDUCTASE  ali model follow..  17  2...........NAMTMKVGFIGLGIMGKPMSKNLLKAGYSLVVSDRNPEAIADV-----------------IAAGAETASTAKAIAEQCDVIITMLPNS------PHVKEVALGENGIIEGAKPGTVLIDMSSIAPLASREISDALKAK-------GVEMLDAP----SGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVHTGDIGAGNVTKLANQVIVALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLD-KPGFRIDLHIKDLANALDTSHGVGAQLPLTAAVMEM....................................................................................................................................... 268
22 -21.3002uyy_A mol:protein length:316 N-PAC PROTEIN  ali model follow..  15  17.......MGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLF-----------------IQEGARLGRTPAEVVSTCDITFACVSDP------KAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFL--EAPVSGNQQLSNDGMLV--------ILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIFLD-KPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEV....................................................................................................................................... 287
23 -21.1003pdu_A mol:protein length:287 3-hydroxyisobutyrate dehydrogenase family protein  ali model follow..  12  2...............TTYGFLGLGIMGGPMAANLVRAGFDVTVWNRNPAKCAPL-----------------VALGARQASSPAEVCAACDITIAMLADP------AAAREVCFGANGVLEGIGGGRGYIDMSTVDDETSTAIGAAVTARGGRFL--EAPVSGTKKPAEDGTLI--------ILAAGDQSLFTDAGPAFAALGKKCLHLGEVGQGARMKLVVNMIMGQMMTALGEGMALGRNCGLDGGQLLEVLDAGAMANPMFK-PTSFPLKHMQKDLRLAVELGDRLGQPLHGAATANES....................................................................................................................................... 264
24 -21.1001yb4_A mol:protein length:295 tartronic semialdehyde reductase  ali model follow..  16  1............SNAMKLGFIGLGIMGSPMAINLARAGHQLHVTTIGPVADELLSLGAV------------------NVETARQVTEFADIIFIMVPDT------PQVEDVLFGEHGCAKTSLQGKTIVDMSSISPIETKRFAQRVNEM-------GADYLDAP----SGGEIGAREGTLSIMVGGEQKVFDRVKPLFDILGKNITLVGGNGDGQTCKVANQIIVALNIEAVSEALVFASKAGADPVRVRQALMGGFASSRILE-EPGFKIALHQKDLNLALQSAKALALNLPNTATCQEL....................................................................................................................................... 265
25 -21.0003obb_A mol:protein length:300 Probable 3-hydroxyisobutyrate dehydrogenase  ali model follow..  17  4...............KQIAFIGLGHMGAPMATNLLKAGYLLNVFDLVQSAVDGLVA-----------------AGASAARSARDAVQGADVVISMLPAS------QHVEGLYLDDDGLLAHIAPGTLVLECSTIAPTSARKIHAAARER-------GLAMLDAP----SGGTAGAAAGTLTFMVGGDAEALEKARPLFEAMGRNIFHAGPDGAGQVAKVCNNQLLAVLMIGTAEAMALGVANGLELAEIMRRSSGGNWALEVYNPSGGFMAQLMAKDLGLAQEAAQASASSTPMGSLALSL....................................................................................................................................... 273
26 -21.0003g0o_A mol:protein length:303 3-hydroxyisobutyrate dehydrogenase  ali model follow..  15  2.........SLTGTDFHVGIVGLGSMGMGAARSCLRAGLSTWGADLNPQACANLLA----------------EGACGAAASAREFAGVVDALVILVVNA------AQVRQVLFGEDGVAHLMKPGSAVMVSSTISSADAQEIAAALTAL-------NLNMLDAP----SGGAVKAAQGEMTVMASGSEAAFTRLKPVLDAVASNVYRISDTPAGSTVKIIHQLLAGVHIAAAAEAMALAARAGIPLDVMYDVVTHAAGNSWMFE-TPRSAVDIFVKDLGLVADTAKALRFPLPLASTALNM....................................................................................................................................... 272
27 -20.5005je8_A mol:protein length:302 3-hydroxyisobutyrate dehydrogenase  ali model follow..  17  4...........KDPMKKIGFIGLGNMGLPMSKNLVKSGYTVYGVDLNKEAEASFEK-----------------EGGIIGLSISKLAETCDVVFTSLPSP------RAVEAVYFGAEGLFENGHSNVVFIDTSTVSPQLNKQLEEAAKEK-------KVDFLAAP----SGGVIGAENRTLTFMVGGSKDVYEKTESIMGVLGANIFHVEQIDSGTTVKLINNLLIGFYTAGVSEALTLAKKNNMDLDKMFDILNVSYGQSRIYE-EPGFTVNLLKKDLGFAVDLAKESELHLPVSEMLLNV....................................................................................................................................... 272
28 -19.6001wp4_A mol:protein length:289 3-hydroxyisobutyrate dehydrogenase  ali model follow..  15  2...............EKVAFIGLGAMGYPMAGHLARRFPTLVWNRTFEKALRHQEEFGS-------------------EAVPLERVAEARVIFTCLPTT---------REVYEVAEALYPYLREGTYWVDATSGEPEASRRLAERLREK-------GVTYLDAP----SGGTSGAEAGTLTVMLGGPEEAVERVRPFLA-YAKKVVHVGPVGAGHAVKAINNALLAVNLWAAGEGLLALVKQGVSAEKALEVINASSGRSNATE-PKTFALGLLVKDLGIAMGVLDGEKAPSPLLRLAREV....................................................................................................................................... 259
29 -19.6005u5g_A mol:protein length:295 6-phosphogluconate dehydrogenase  ali model follow..  18  2..............NRVVGFIGLGRMGQAICRRLLASQMPVHVHNRSREKADDL-----------------IRQGAVWAPDIVALTRAARVLFVCTAGSEAVQ-----DFYHAPDRGLLACLEVGDIVVDLSTIAPETAEGLHAAFAQQGADYI--ECPVSGGVEGALAGILS--------AIVSGRPEAYGLIRPLLEVFCATVTYVPEPGKAQRLKILNNLAESINLAGAIEVISQGLSQGLDLKSMADVFTSCRGRSAYMD-SSNVSLGVRCKDLELARRRLPQ-DQSYPFSTLAMTT....................................................................................................................................... 265
30 -19.4004d3s_A mol:protein length:293 IMINE REDUCTASE  ali model follow..  10  1.......MTNTKAKKSPVTLIGLGPMGQAMAGALLEAGYELTVWNRTKAKAEAL-----------------AERGAAVADSPAEALRAGGPVLLSL---------TEHAVMYRVLEGAESDL-KGRTILNLGSDTPAASRAAAAWAEGHGARYV--TGGVMSPAPGIGSSSVF--------SFYSGDRAAFEENKALLEVLTATDFRGEDPGLAQVYYQILLDLFWTTMTGYLHALAVARAEGVPVGTITPYLIEGNDMAMFFFPGDEDRISMDAASMEHVVQTSRDAGVDTALPEAVLSLFRRGLDA-FARLVTLMDAEG................................................................................................................... 293
31 -19.3004gbj_A mol:protein length:297 6-phosphogluconate dehydrogenase NAD-binding  ali model follow..  14  2...........NAMSEKIAFLGLGNLGTPIAEILLEAGYELVVWNRTASKAEPLTK-----------------LGATVVENAIDAITPGGIVFSVLAD--------DAAVEELFSMELVEKLGKDGVHVSMSTISPETSRQLAQVHEWYGAHYV--GAPIFARPEAVRAKVGN--------ICLSGNAGAKERIKPIVENFVKGVFDFDDPGAANVIKLAGNFMIACSLEMMGEAFTMAEKNGISRQSIYEMLTSTLFAAPIFYEPVAFRFPLGLKDINLTLQTASDVNAPMPFADIIRNR....................................................................................................................................... 268
32 -19.3005a9r_A mol:protein length:290 IMINE REDUCTASE  ali model follow..  14  1..........MTDQNLPVTVAGLGPMGSALAAALLDRGHDVTVWNRSPGKAAPL-----------------VAKGARQADDIVDAVSASRLLVVCL---------ADYDALYSALGPAREAL-RGRVVVNLNSGTPKEANEALRWAERHGTGYL--DGAIMVPPAMVGHPGSV--------FLYSGSAEVFEEYKETLAGLGDPVHLGTEAGLAVLYNTALLSMMYSSMNGFLHAAALVGSAGVPAAEFTKLAVDWFLPAVI-YPGDAGSLEMNVTTLKHIIGTSQEQGVDTEIPVRNKEL....................................................................................................................................... 268
33 -19.3004dll_A mol:protein length:320 2-hydroxy-3-oxopropionate reductase  ali model follow..  14  13..YFQSMTVESDPYARKITFLGTGSMGLPMARRLCEAGYALQVWNRTPARAASLAA-----------------LGATIHEQARAAARDADIVVSMLENG------AVVQDVL-FAQGVAAAMKPGSLFLDMASITPREARDHAARLGAL-------GIAHLDTP----SGGTVGAEQGTLVIMAGGKPADFERSLPLLKVF-GRATHVGPHGSGQLTKLANQMIVGITIGAVAEALLFATKGGADMAKVKEAITGGFADSRVLQ-APRARLSIQLKDMRNALATAQEIGFDAPITGLFEQL....................................................................................................................................... 286
34 -18.9003zgy_A mol:protein length:309 R-IMINE REDUCTASE  ali model follow..  10  10.....RMMRNQQAEHTPVTVIGLGLMGQALAGAFLGAGHPTTVWNRTAAKAEPL-----------------VARGAKSAGSVAEAVAASPLVVVCV---------SDYDAVHALLDPLDGTALQGRTLVNLTSGTSAQARERAAWADGRGADYL--DGAILAGPAAIGTADAV--------VLLSGPRSAFDPHASALGGLGAGTTYLADHGLASLYDAAGLVMMWSILNGFLQGAALLGTAGVDATTFAPFITQGIGTVADWYPADDAAIDTHLATMEHLIHESEFLGVNAELPRFIKAL....................................................................................................................................... 282
35 -18.7004d3d_A mol:protein length:310 IMINE REDUCTASE  ali model follow..  11  14.......TTNAVGNRKSVTVIGLGPMGQAMADVFLEYGYSVTVWNRTSSKADQL-----------------VAKGAIRVSTVNEALAANELVILSL---------TDYNVMYSILEPVSENL-FGKVLVNLSSDTPEKARKAAKWLEDRGARHI--TGGVQVPPSGIGKSESY--------TYYSGDRVVFEAHRETLEVLTSSDYRGEDPGLAMLYYQIQMDIFWTAMLSYLHALAIANANGITAEQFLPYASAMMSSLPKFVEFYT---AMGLASVEHVVHTTQEAGIDIALPATVLEV....................................................................................................................................... 282
36 -18.4004oqy_A mol:protein length:290 (S)-imine reductase  ali model follow..  11  2.............SKQSVTVIGLGPMGQAMVNTFLDNGHEVTVWNRTASKAEAL-----------------VARGAVLAPTVEDALSANELIVLSL---------TDYDAVYAILEPVTGSL-SGKVIANLSSDTPDKAREAAKWAAKHGAKHL--TGGVQVPPPLIGKPESS--------TYYSGPKDVFDAHEDTLKVLTNADYRGEDAGLAAMYYQAQMTIFWTTMLSYYQTLALGQANGVSAKELLPYATMMTSMMPHFLELYA---AMGAASVDHVLHTHQDAGVSTVLPAAVAEI....................................................................................................................................... 264
37 -17.6005g6r_A mol:protein length:295 IMINE REDUCTASE  ali model follow..  11  2..............SKHIGIFGLGAMGTALAAKYLEHGYKTSVWNRTTAKAIPL-----------------VEQGAKLASTISEGVNANDLIIICL---------LNNQVVEDALRDALQTL-PSKTIVNLTNGTPNQARKLADFVTSHGARYI--HGGIMAVPTMIGSPHAV--------LYSGESLELFQSIESHLSLLGMSKYLGTDAGSASLHDLALLSGMYGLFSGFLHAVALIKSGQDTSTTATGLLPLLTPWLSAMYATQGSNLGMQLAGVENIIRAGEEQRVSSQMILPIKAL....................................................................................................................................... 267
38 -17.5005ocm_A mol:protein length:291 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase  ali model follow..  12  2.............RDTDVTVLGLGLMGQALAGAFLKDGHATTVWNRSEGKAGQL-----------------AEQGAVLASSARDAAEASPLVVVCV---------SDHAAVRAVLDPLGDVL-AGRVLVNLTSGTSEQARATAEWAAERGITYL--DGAIMAIPQVVGTADAF--------LLYSGPEAAYEAHEPTLRSLGAGTTYLADHGLSSLYDVALLGIMWGTLNSFLHGAALLGTAKVEATTFAPFANRWIEAVTGFYPALDATIDTHVATVDHLIHESEAAGVNTELPRLVRTL....................................................................................................................................... 265
39 -17.3004oqz_A mol:protein length:289 Putative oxidoreductase YfjR  ali model follow..  12  2..............SQSVTVIGLGPMGQAMAAAYLDRGYEVTLWNRTASRADAL-----------------VARGAKLAATPEQALSANELVILSL---------IDYDAMYGVLEGAEEAV-AGRVLVNLSSDTPEKARAAARRVAELGGTHL--TGGVLSPPPGIGSPDMS--------TFYSGPRAAYDQHRAALEVITGKTDYREDPGLAALMYQLNMVVFWPAMLSYWQAVALADAHGLTAADIAPYVSENFAGMGQFHAGDVDRLSMGVASMEHVVHTNADSGVDTAFPRAVLDA....................................................................................................................................... 264
40 -16.8003l6d_A mol:protein length:306 Putative oxidoreductase  ali model follow..  14  1......MSLSDESFEFDVSVIGLGAMGTIMAQVLLKQGKRVAIWNRSPGKAAAL-----------------VAAGAHLCESVKAALSASPATIFVLLDNHATHEVLGMPGVARAL--------AHRTIVDYTTNAQDEGLALQGLVNQAGGHYV--KGMIVAYPRNVGHRESH--------SIHTGDREAFEQHRALLEGLAGHTVFLPW-DEALAFATVLHAHAFAAMVTFFEAVGAGDRFGLPVSKTARLLLETSRFFVA-FKGDQARLDVHADAFAHIAQSLHAQGVWTPVFDAVCQV....................................................................................................................................... 272
41 -16.4003qsg_A mol:protein length:312 NAD-binding phosphogluconate dehydrogenase-like protein  ali model follow..  12  13.........YFQSNAMKLGFIGFGEAASAIASGLRQAGADMAAYDAASAESWR----------------RAEELGVSCKASVAEVAGECDVIFSLVTA----------QAALEVAQQAGPHLCEGALYADFTSCSPAVKRAIGDVISRHRPSAQYAAVAVM--------SAVKPHGHRVPLVVDG--DGARRFQAAFTLYGCRIEVLDGEVGGAALLKMCRSAVLKGLEALFLEALAAAEKMGLADRVLASLDASFP--ALYLVERNLEHADRRAHELGEVAATLCSVGVEPLVAEAGYRR....................................................................................................................................... 275
42 -16.2004ezb_A mol:protein length:317 uncharacterized conserved protein  ali model follow..  13  12........LYFQSMMTTIAFIGFGEAAQSIAGGLGGRNAALAAYDLRFNDPAA-----------SGALRARAAELGVEPLDDVAGIACADVVLSLVVG----------AATKAVAASAAPHLSDEAVFIDLNSVGPDTKALAAGAIATGKGSFVEGAVM----------ARVPPYAEKVPILVAGRRAVEVAERLNALG--MNLEAVGETPGQASSLKMIRSVMIKGVEALLIEALSSAERAGVTERILDSVQETFP--ADYYLSRTFEHGARRVTEMTEAAETIESFGLNAPMSRAACET....................................................................................................................................... 277
43 -15.7005ojl_A mol:protein length:298 Imine reductase  ali model follow..  13  4...........TTTTTKLTIFGLGAMGTAMATQFLKQGHTPTVWNRTAAKANPL-----------------VEQGAHLAATIPAAIAASPLLIFCL---------LDNAAVEQTLAAGPPSL-AGKTILNLTNGTPSQARRLATLASARGARYF--HGGIMATPDMIGAPHAV--------YSGGGSAETYASVEGVLAVLGSGKYLGDDAGSASLHDLALLSGMYGLFALHATALVRSEGEGVSATEFLGLLAPWLQAMTGYYTAQTSNLEMQLVALENACAASREQGVSAEVMLPLKGL....................................................................................................................................... 272
44 -15.4001bg6_A mol:protein length:359 N-(1-D-CARBOXYLETHYL)-L-NORVALINE DEHYDROGENASE  ali model follow..  13  2............IESKTYAVLGLGNGGHAFAAYLALKGQSVLAWDIDAQRIKEIQDRGAIIAEGPGLAGTAHPD---LLTSDILAVKDADVILIVVPA----------IHHASIAANIASYISEGQLIILNPG-----GALEFRKILRENGAPEVTIGETSSMLRSERPGQVTVNAIKGAMDFACLPAAKAGWALEQIGSVLPQYVAVENVLHTSLTNVITPSVGSLAEKVDAERIAIAKAFDLNVPSVCEWYKES--AYRGIAGPINLNTRYFFEDVSTLSELGRAVNVPTPLIDA------------VLDLISSLIDTDFRKEGRTLEKLGLS-GLTAAGIRS........................................................................................... 356
45 -14.3001i36_A mol:protein length:264 CONSERVED HYPOTHETICAL PROTEIN MTH1747  ali model follow..  12  1...............LRVGFIGFGEVAQTLASRLRSRGVEVVTSLEGRSPSTIERARTVGVTE-----------------TSEEDVYSCPVVISAVTP----------GVALGAARRAGRHV--RGIYVDINNISPETVRMASSLIEKGGFVDAAI-------------GSVRRKGADIRIIASGRDAEEFMKLNRYGLNIE---VRGREPGDASAIKMLRSSYTKGVSALLWETLTAAHRLGLEVLEMLEYTEGNDFRESARLKSSCIHARRRYEEMKEVQDMLAEVIDPVMPTCIIRIFDK..................................................................................................................................... 248
46 -14.2004e21_A mol:protein length:358 6-phosphogluconate dehydrogenase (Decarboxylating)  ali model follow..  13  10........ENLYFQSMQIGMIGLGRMGADMVRRLRKGGHECVVYDLNVNAVQALER------------------EGIAGARSIEEFCAVKPRVVWLMVP---------AVVDSMLQRMTPLLAANDIVIDGGNSHYQDDIRRADQMRAQG---------ITYVDVGTSGG--IFGLERGYCLMIGGEKQAVERLDPVFRTLAPGILHCGPSGAGHFVKMVHNGIEYGLMAAYAEGLNILHHANAGKEGQGADAET..................................................................................................................................................................................... 241
47 -14.1003c24_A mol:protein length:286 Putative oxidoreductase  ali model follow..  14  3......VKDKNDVGPKTVAILGAGKMGARITRKIHDSAHHLAAIEIAPEGRDRLQG-------------------GIPLTDGDGWIDEADVVVLALPD----------NIIEKVAEDIVPRVRPGTIVLILDAAAPYAGVMPERADITYFIGHPCHPPLFNDETDPAARTDYHGGIAKQAIVCMQGPEEHYAIGADICETMWSPVTRTHRVTTEQLAILEPGLSEMVAMPFVETMVHAVDEC.................................................................................................................................................................................................. 213
48 -14.1001pgj_A mol:protein length:478 6-PHOSPHOGLUCONATE DEHYDROGENASE  ali model follow..  16  1..............SMDVGVVGLGVMGANLALNIAEKGFKVAVFNRTYSKSEEFMK----------------ANASAPFAGNLKAFETMEAFAASLKKPRK----QAGAATDSTIEQLKKVFEKGDILVDTGNAHFKDQGRRAQQLEAAG------GMGISGGEEGARKGPA---------FFPGGTLSVWEEIRPIVEAAAAKVTMNGSGGAGSCVKMYHNSGEYAILQIWGEVFDILRAMGLNNDEVAAVLED..................................................................................................................................................................................... 222
49 -13.7005t57_A mol:protein length:296 Semialdehyde dehydrogenase NAD-binding protein  ali model follow..  17  4..SSSGLVPRGSHMKEKIALFGAG-MGVRLAKNLLKSDYRVSHVEVSEVGKKRLKD-----------------ELGLECVSTEAALDNVDVVILAVPD----------TIIGKIAAQIAPQLRPGTMVMTLDAAAPFAGHLPDRPDLT----------YFVAHPCHPLIFNDETDPEARRDYFGGGPEEAFDLGEAVAKVIILRSYRLTVDQMALLEPGLSETICATLLQVMREAMDETVRRGVPKEAARDFL....................................................................................................................................................................................... 234
50 -13.3002yjz_A mol:protein length:201 METALLOREDUCTASE STEAP4  ali model follow..  13  16...........SEKQGVVCIFGTGDFGKSLGLKMLQCGYSVVFGSRNPQVSSLLPRG-------------------AEVLCYSEAASRSDVIVLAVHREHYD------FLAELADSLKGRVLIDVSNNQKMNQYPESNAEYLAQLVPGAHVVKAFNTISAWALQSGTLDASRQ--------FVCGNDSKAKDRVMDIARTLGLTPLDQGSLVAAKEIE.......................................................................................................................................................................................................................... 190
51 -13.1005uq9_A mol:protein length:489 6-phosphogluconate dehydrogenase, decarboxylating  ali model follow..  15  6...........IMAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLAN---------EAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAG---------QAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKG------GSGVSGGEEGARYGPS---------LMPGGNKEAWPHIKTIFQGIAAKCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGEMAQAFEDWNKTELDSFLIE............................................................................................................................................................................ 240
52 -13.1002p4q_A mol:protein length:497 6-phosphogluconate dehydrogenase, decarboxylating 1  ali model follow..  15  2............GMSADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLAN-------------AKGKSIIGATSIEDFISKLKRPRKVMLLV------KAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKG------GSGVSGGEEGARYGPS---------LMPGGSEEAWPHIKNIFQSISAKSEWVGPAGAGHYVKMVHNGIEYGDMQLICEAYDIMKRLGGFTDKEISDV....................................................................................................................................................................................... 219
53 -13.1002zyg_A mol:protein length:480 6-phosphogluconate dehydrogenase, decarboxylating  ali model follow..  16  1..........MGMSKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIA-------------ENPGKKLVPYYTVQEFVESLETPRRILLMV------KAGAGTDSAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEG------GTGVSGGEEGTLKGPS---------IMPGGQKEAYELVAPILKQI-PCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYALLKGGLALSNEELAQT....................................................................................................................................................................................... 220
54 -13.0002jkv_A mol:protein length:505 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING  ali model follow..  15  12.......LYFQSMAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLA---------NEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAG---------QAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKG------GSGVSGGEEGARYGPS---------LMPGGNKEAWPHIKTIFQGIAAKCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQA-------------------------FEDWNKTELDSFLIEITANILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISAL......................................................................................................... 288
55 -13.0003d1l_A mol:protein length:266 Putative NADP oxidoreductase BF3122  ali model follow..  11  5.........KRSIEDTPIVLIGAGNLATNLAKALYRKGFRIVQV-----------------RTEESARELAQKVEAEYTTDLAEVNPYAKLYIVSLKD----------SAFAELLQGIVEGKREEALMVHTA----GSIP---MNVWEGHVPHYG-----VFYPMQTFSKQREVDFKEIPFFIEASSTEDAAFLKAIASTLSNRVYDADSEQRKHLAAVFTCNFT---NHMYALAAELLKKYNLPFDVMLPLIDETARKVHELEPKTAQTGPAIRYDENVIGNHLRMLADDPAMQRLYELLSRSI................................................................................................................................... 262
56 -13.0002zya_A mol:protein length:480 6-phosphogluconate dehydrogenase, decarboxylating  ali model follow..  14  1..........MGMSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIA-------------ENPGKKLVPYYTVKEFVESLETPRRILLMV------KAGAGTDAAIDSLKPYLDKGDIIIDGGNTFFQDTIRRNRELSAEG------GTGVSGGEEGALKGPS---------IMPGGQKEAYELVAPILTKIAPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNELAQTFTEWNNGELSSYLID............................................................................................................................................................................ 235
57 -13.0004yte_A mol:protein length:194 H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ0715  ali model follow..  10  11.......QRLYLEQLKVPEKFGGEPPYAGMAIEFAKAGHDVVLSEPNRDVMSDDLWKKV------------EDAGVKVVSDDIEAAKHGEIHVLFTPFG---------RITLNIANTIIEHVPENAIICNTCTIPTPVLYR----SLEGILRLKRRDVGISSMHPTGVPGTPSQKYYTIAGKAL-ATEDQINKLVELVKSVGKIPYVTPA.................................................................................................................................................................................................................................. 194
58 -13.0004ypo_A mol:protein length:333 Ketol-acid reductoisomerase  ali model follow..  12  13.............QGRKVGVIGYGSQGHAHSLSLRDSGVQVRVGLKQGSRSRPK-----------------VEEQGLDVDTPAEVAKWADVVMVLA---------PDTAQAEIFAGDIEPNLKPGDALFFGHGLNVHFGLIKPPADVAV--AMVAPKGPGHLVRRQFVDGKGVPCLVA---VEQDPRGDGLALALSYAKAIGGTRAGVIKTTFKDETETEQTVLCGGTEELVKAGFEVMVEAGYPAELAYFEV....................................................................................................................................................................................... 225
59 -12.9002f1k_A mol:protein length:279 prephenate dehydrogenase  ali model follow..  14  1...............MKIGVVGLGLIGASLAGDLRRRGHYLIGVSRQQSTCEKAVERQL------------------EAGQDLSLLQTAKIIFLCTP----------IQLILPTLEKLIPHLSPTAIV-----TDVASVKTAIAEPASQLWSG-----FIGGHPAAQGIDGAEENLFVNAPYVLYTDPEQLACLRSVLEPLGVKIYLCTPADHDQAVAWISHLPVMVSAALIQACAGEKDGDILKLAQNLASSG--------------------------FRDTSRVGGGNPELGTMMATYNQRALLKSLQDYRQHLDQLITLISNQQWPELHRLLQ-QTNGDRDK.......................................................................................... 276
60 -12.9002w90_A mol:protein length:471 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING  ali model follow..  16  4.............AKHQIGVIGLAVMGKNLALNIESKGYSVAVYNRLREKTDEFLQ-------------EAKGKNIVGTYSIEEFVNALEKPRKILLMV------KAGAPTDATIEQLKPHLEKGDIVIDGGNTYFKDTQRRNKELAELG------GTGVSGGEEGALKGPS---------IMPGGQKEAHELVRPIFEAIAAKVTYIGPDGAGHYVKMVHNGIEYGDMLIAEAYFLLKHVLGMDAAELHEVFAD..................................................................................................................................................................................... 222
61 -12.8003dtt_A mol:protein length:245 NADP oxidoreductase  ali model follow..  10  3....SDKIENLYFQGMKIAVLGTGTVGRTMAGALADLGHEVTIGTRDPKATLARAEPDAM--GAPPFSQWLPEHPHVHLAAFADVAAGAELVVNATEG----------ASSIAALTAAGAENLAGKILV-DIANPLDFSHGMPPTLNPVNTDSL---------------GEQIQRTFPEAKVVKTLNTMNASLMVDPGRAAGGDHSVFVSGNDAAAKAEVATLLKSLGHQ------------VIDLGDITTARGAEMLLPVWIRLWGALGTA.................................................................................................................................................................... 231
62 -12.7006fqx_A mol:protein length:468 6-phosphogluconate dehydrogenase, decarboxylating  ali model follow..  9  2...............CDIGLIGLAVMGQNLSLNISSKGFKIGVYNRTYERTEET-----------------MKRAKEENLVVYGYKTVEELINNLKKPRKVILLIKAGPAVDENISNILKHFEKGDIIIDGGNEWYINSERRIKLCKEKD------AMGVSGGEAGARYGCS---------FMPGGSKYAYDCVKEILEKCSAQVTYIGPGSSGNYVKMVHNGIEYGDMQLISESYVIMKHILKYDNQKLSEV....................................................................................................................................................................................... 217
63 -12.7004yt4_A mol:protein length:375 H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338  ali model follow..  11  2.....RNIRKIKVDNMKVSVYGAGKFGGRMAIEFAEAGHDVVLAEPNKNIMSDDLWKKV------------EDAGVKVVSDDVEAAKHGEIHVLFTPFG---------KATFRIAKTIIEHVPENAVICNTCTVSPVVLYYSLEPILRTKR----KDVGISSMHPAAVPGTPQHGHYVIGGGKELATEEQIKKAVELAKSAGKEAYVVPADVSSVVADMGSLVTAVALSGVLDYYTV....................................................................................................................................................................................................... 232
64 -12.7002iz0_A mol:protein length:474 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING  ali model follow..  13  4.............AQANFGVVGMAVMGKNLALNVESRGYTVAIYNRTTSKTEEVFK-------------EHQDKNLVFTKTLEEFVGSLEKPRRIMLMV------QAGAATDATIKSLLPLLDIGDILIDGGNTHFPDTMRRNAELADSG------GTGVSGGEKGALLGPS---------MMPGGQKEAYDLVAPIFEQIAAKAAYMGANGAGHYVKMVHNGIEYGDMQLIAESYDLLKRILGEIQAIFEEWNEGELDSYLIE............................................................................................................................................................................ 236
65 -12.5005t95_A mol:protein length:271 Prephenate dehydrogenase 1  ali model follow..  12  1......MSTSSSSQSLKIGIVGFGNFGQFLAKTMIKQGHTLTATSRSDYSELCLQMGIH------------------FRDVSAFLTADIDVIVLCTS----------ILSLSEVVGSMPTSLKRPTLFVDVLSVKEHPRELLLRELPEDSDILCTHPM---FGPQTAKNGWTDHTFMYDK--VRIRDEVICSNFIQIFATEGCKMVQMSCEEHDRAAAKSQFITHTIGRTLGEMDIQSTPIDTKGFETLVKLKET..................................................................................................................................................................................... 218
66 -12.4002raf_A mol:protein length:209 Putative Dinucleotide-Binding Oxidoreductase  ali model follow..  10  3....SDKIENLYFQGMEITIFGKGNMGQAIGHNFEIAGHEVT-----------------------------------YYGSKDQATTLGEIVIMAVP----------YPALAALAKQYATQLKGKIVVDITNPLNFDTWDDLVVPADSSAAQELQQQLPDSQVLKAFNQSGQVNGKEPTTVLVAGNDDSAKQRFTRALADSPLEVKDAGKLKRARELEAMGFMQMTLAAS.............................................................................................................................................................................................................. 190
67 -12.3001pgn_A mol:protein length:482 6-PHOSPHOGLUCONATE DEHYDROGENASE  ali model follow..  17  2..............QADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLAN-------------AKGTKVLGAHSLEEMVSKLKKPRRIILLV------KAGQAVDNFIEKLVPLLDIGDIIIDGGNSEYRDTMRRCRDLKDKG------GSGVSGGEDGARYGPS---------LMPGGNKEAWPHIKAIFQGIAAKVDWVGDDGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGLGHKEMAKA....................................................................................................................................................................................... 218
68 -12.3003hwr_A mol:protein length:318 2-dehydropantoate 2-reductase  ali model follow..  15  3....SDKIENLYFQGMKVAIMGAGAVGCYYGGMLARAGHEVILI-ARPQHVQAIEATGLRLETQSFDEQVK-----VSASSDPSAVQGADLVLFCVKS----------TDTQSAALAMKPALAKSALVL---SLQNGVENADTLRSLLEQEVAAAV---VYVATEMAGPGHVRHH--GRGELVIEPTSHGANLAAIFAAAGVPVET-SDNVRGALWAKLILNC--------YNALSAI---TQLPYGRLVRGEGVEAVMRDVMEECFAVA-------------RAEGVKLPDDVALAIRRIAETMPRQSSSTAQDLARGKRSEIDHLNGLIVRRGDALGIPVPANRVLHALVRLIEDK.............................................................................. 308
69 -12.3003wfi_A mol:protein length:312 2-dehydropantoate 2-reductase  ali model follow..  15  1...............MKIAIAGAGAMGSRFGLMLHQSGNEVLLIDGWAEHVQQIKEHGLQANFNGKEVEAKL---PIVLQSEVEKEDQVDLIILFTKA----------MQLEKMLQDIQSLIKKDTEVL---CLLNGIHEDIIEKFVPMENIYIGN---TMWTAGLEGPGQVKLFGSGSVELLGDGKEAAAKKLADKLSESGLNAHFSDNIHYSIYRKACVNGAHKMVATIVNEFAKVAAVEKIEL-ESCFDPETIGLHYPSMYQDLIKNHRLTEID--AISRKGKKYGVATPYCDFLTEL....................................................................................................................................... 301
70 -12.1002ew2_A mol:protein length:316 2-dehydropantoate 2-reductase, putative  ali model follow..  15  1............SNAMKIAIAGAGAMGSRLGIMLHQGGNDVTLIDQWPAHIEAIRKNGLIADFNGEEVVANLPI--FSPEEIDHQNEQVDLIIALTKA----------QQLDAMFKAIQPMITEKTYVL---CLLNGLHEDVLEKYVPKENILVGI---TMWTAGLEGPGRVKLLGDGEIELIDPSGKKFALEVVDVFQKAGLNPSYSSNVRYSIWRKACVNGSESLVKTLISEFAAVAEKEAIYLDQ-TYDPNGIGLHYPSMYQDLIKNHRLTEID--AVWRKGQKYNVATPFCAMLTQL....................................................................................................................................... 305
71 -12.1001np3_A mol:protein length:338 Ketol-acid reductoisomerase  ali model follow..  10  15.............QGKKVAIIGYGSQGHAHACNLKDSGVDVTVGLRSGSATVAK-----------------AEAHGLKVADVKTAVAAADVVMILTP---------DEFQGRLYKEEIEPNLKKGATLAFAHGFSIHYNQVVPRADLDV--IMIAPKAPGHTVRSEFVKGGGIPDLIAIYQ-SGNAKNVALSYACGVGGGRTGIIETTFKDETETDLFGEQAVLCGGCVELVKAGFETLVEAGYAPEMAYFECELKLIVDLMYEGGIANMNYSISNNAEYGEYVTGPEVINAESRAAMRNAKRIQDGEYAKMFITSMTAYRRNNAAHPIEQIGEKLRAMMPWIAANKIVD...................................................................................... 334
72 -11.9002vns_A mol:protein length:215 METALLOREDUCTASE STEAP3  ali model follow..  13  25...........PDEAPKVGILGSGDFARSLATRLVGSGFKVVVGSRNPKRTARL------------------FPSAAQVTFQEEAVSSPEVIFVAVFREH-----------YSSLCSLSDQLAGKILVDVSNPTEQEHLQHRESNAEYLASLFPTCTVVKAFNVISAWTLQAGPRDGNRQVPICGDQPEAKRAVSEMALAMGFMPVDMGSLASAWEVEAMPLRLLPAW................................................................................................................................................................................................................ 212
73 -11.9004xiy_A mol:protein length:338 Ketol-acid reductoisomerase  ali model follow..  11  15.............QSKKVAIIGYGSQGHAHACNLKDSGVDVYVGLRAGSASVAK-----------------AEAHGLTVKSVKDAVAAADVVMILTP---------DEFQGRLYKDEIEPNLKKGATLAFAHGFSIHYNQVVPRADLDVI--MIAPKAPGHTVRSEFVRGGGIPDLIAVYQDASGNAKNLALSYACGVGGGRTGIIETTFKDETETDLFGEQAVLGGCVELVKAGFETLVEAGYAPEMAYFEC....................................................................................................................................................................................... 227
74 -11.9001txg_A mol:protein length:335 glycerol-3-phosphate dehydrogenase [NAD(P)+]  ali model follow..  13  1...............MIVSILGAGAMGSALSVPLVDNGNEVRGTEFDTEILKSISAG-----REHPRLGVKLNGVEIFWPEQLKCLENAEVVLLGVST----------DGVLPVMSRILPYLKDQYIVLISKGLIDFDNSLTVPEAVWRLKHDLRERTVAITGPAIARE---VAKRMPTTVVFSSPSESSANKMKEIFETEYFGVEVTTDIIGTEITSALKNVY-SIAIAWINAKGVIATRAINEMAELIEILGGDRETAFGL---SGFG------DLIATFRGGRNGMLGELL---------GKGLSIDEAMEELERRGVGVVEGYKTAAYRLSSKINA----DTKLLDSIYRVLYEGLKVE......................................................................... 325
75 -11.8003f3s_A mol:protein length:313 Lambda-crystallin homolog  ali model follow..  12  1............SMAGCVVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNIRKEMKLLEQAGSSLSVEEQLSLISGCPNIEAVEGAMHIQECVPE--------DLELKKKIFAQLDSIIDDRVILSSSTSC---MPSKLFAGLVHVKQCIVAHPV----NPPYYIP-----------ELVPHTAPTTVDRTHALMKKIGQCPMRVQK----EVAGFVLNR---LQYAIISEAWRLVEEGIVSPSDLDLVMSE------------GLGMRYAFIGPLETMHLN-AEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQ............................................................................... 312
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.