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Query: [C] KOG1257 NADP+-dependent malic enzyme, from COG1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITELast
1 -150.0001efk_A mol:protein length:584 MALIC ENZYME  ali model follow..  100  1MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE 584
2 -143.0002aw5_A mol:protein length:575 NADP-dependent malic enzyme  ali model follow..  53  7...........LGTENLYFQSMQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQEKEKFAH---EHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFVRSQMYSTDYDQILPDCYSWPEEVQ....... 569
3 -143.0003wja_A mol:protein length:580 NADP-dependent malic enzyme  ali model follow..  53  2...........EPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQEKEKFAH---EHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFVRSQMYSTDYDQILPDCYSWPEEVQKIQTKVD 571
4 -140.0001llq_A mol:protein length:605 NAD-dependent malic enzyme  ali model follow..  50  17..MDEKEMALYKLYRPERVTPKKRSAELLKEPRLNKGMGFSLYERQYLGLHGLLPPAFMTQEQQAYRVITKLREQPNDLARYIQLDGLQDRNEKLFYRVVCDHVKELMPIVYTPTVGLACQNFGYIYRKPKGLYITINSVSKIYQILSNWHEEDVRAIVVTDGERILGLGDLGAYGIGIPVGKLALYVALGGVQPKWCLPVLLDVGTNNMDLLNDPFYIGLRHKRVRGKDYDTLLDNFMKACTKKYGQKTLIQFEDFANPNAFRLLDKYQDKYTMFNDDIQGTASVIVAGLLTCTRVTKKLVSQEKYLFFGAGAASTGIAEMIVHQMQNEGISKEEACNRIYLMDIDGLVTKNRKEMNPRHVQFAK---DMPETTSILEVIRAARPGALIGASTVRGAFNEEVIRAMAEINERPIIFALSNPTSKAECTAEEAYTFTNGAALYASGSPFPNFEL-NGHTYKPGQGNNAYIFPGVALGTILFQIRHVDNDLFLLAAKKVASCVTEDSLKVGRVYPQLKEIREISIQIAVEMAKYCYKNGTANLYPQPEDLEKYVRAQVYNTEYEELINATYDWPEQDMR...... 590
5 -139.0001gq2_A mol:protein length:555 MALIC ENZYME  ali model follow..  56  1......................KKGYEVLRDPHLNKGMAFTLEERQQLNIHGLLPPCFLGQDAQVYSILKNFERLTSDLDRYILLMSLQDRNEKLFYKVLTSDIERFMPIVYTPTVGLACQHYGLAFRRPRGLFITIHDRGHIATMLQSWPESVIKAIVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVKPHQCLPVMLDVGTDNETLLKDPLYIGLRHKRIRGQAYDDLLDEFMEAVTSRYGMNCLIQFEDFANANAFRLLHKYRNKYCTFNDDIQGTASVAVAGLLAALRITKNRLSDHTVLFQGAGEAALGIANLIVMAMQKEGVSKEEAIKRIWMVDSKGLIVKGRASLTPEKEHFAH---EHCEMKNLEDIVKDIKPTVLIGVAAIGGAFTQQILQDMAAFNKRPIIFALSNPTSKAECTAEQLYKYTEGRGIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVALGVISCGLKHIGDDVFLTTAEVIAQEVSEENLQEGRLYPPLVTIQQVSLKIAVRIAKEAYRNNTASTYPQPEDLEAFIRSQVYSTDYNCFVADSYTWPEEAMKVK.... 555
6 -136.0006C7N Entity 1(prereleased)  ali follow..  47  52..VVEVAAANEELPVMPWATSVASGYTLLRDPRHNKGLAFTERERDAHYLRGLLPPAVVSQELQIKKFMNNLRQYQLPIQCYMAMMNLQETDERLFYKLLIENVVELLPYVYTPTVGEACQKYGSIFGRPQGLYVSLKDKGRVLEVLRNWPHRNVQVICVTDGERILGLGDLGCQGMGIPVGKLALYTALGGVDPSACLPITIDVGTNNEKLLNDEFYIGLRQKRARGEEYDELMEEFMAAVKTFYGEKVLIQFEDFANHNAFDLLEKYSKTHLVFNDDIQGTASVVLAGLLAALKMVGGTLAEQTYLFLGAGEAGTGIAELIALEMSKQKAPIEECRKKVWLVDSKGLIVDSRKSSLAPFKKPWA--HEHEPLTTLYDAVQSIKPTVLIGTSGVGRTFTKEIVEAMASINERPIIFSLSNPTSHSECTAEQAYTWTQGRAVFASGSPFAPVEY-DGKTFVPGQSNNAYIFPGLGLGLVISGAVRVHEDMLLAASAALADQATEENFVTGSIFPPFTNIRKISAYIAAAVAAKAYELGLATRLPPPKDLVAYAESCMYSPVYRNY................... 612
7 -88.9003nv9_A mol:protein length:487 Malic enzyme  ali model follow..  21  1....................................................................MAQLKADLSNLEECLLSQEQRAVAKTQFYKELAEKVHKFYKIQIMPKCTLAGFNWFNAYYTPGVSRISTNIRDNNDSSLFYSL-RGNFVGVVSDSTRVLGDGDVTPGGLGVMEGKALLMKYLGGI---------------------DAVPICIDSKNKEGKNDPDAVIEFVQRIQHTFG-AINLEDISQPNCYKILDVLRESCDIPVWHDDQQGTASVTLAGLLNALKLVKKDIHECRMVFIGAGSSNTTCLRLIVTAGA--------DPKKIVMFDSKGSLHNGREDIKKDTRFYRKWCETTNPSKFGSIAEACVGADVLISLSTPGPGVVKAEW--IKSMGEKPIVFCCANPVPEIYPYEAKEAGAY---------------IVATGRGDFPNQVNNSVGFPGILKGALIVRARKITDNMAIAASRALAEFAEKRGINPDNIIGTMDE-PGIFPKEAADVAMQAIKDGVARVTDTWQQVYDIAEHDIKEARESAQSKHIVDFPQETLN...... 474
8 -82.7001ww8_A mol:protein length:439 malate oxidoreductase  ali model follow..  22  1......................................................................MIREKALEFHKNNFPGNG---KIEVIPKVSLESREEL-TLAYTPGVAEPCKEIA-----------------RDPGKVYEYTSKGNLVAVVSDGSRILGLGNIPLAGLPVMEGKALLFKRFGGVDAFPIMIKEQEP------------------------------NKFIDIVKAIAPTFGGINLEDIASPKCFYILERLREEIPVFHDDQQGTAAVVLAGLLNALKVVGKKISEITLALFGAGAAGFATLRILTEAGVK-----PENVRVVELVNGKPRILTSDLDLEKLFPYRGLKKTNGENIEGGPQEALKDADVLISFTRPGPGVIKPQWIEKM---NEDAIVFPLANPVP--EILPEEAKKAGARIVA-------------TGRSDYPNQINNLLGFPGIFRGALDVRARTITDSMIIAAAKAIASIVEEPSEENIIPSP---LNPIVYAREARAVAEEAMKEGVARTKVKGEWVEEHTIRLIYENVIAPINKKRREYSKA......... 435
9 -81.6002a9f_A mol:protein length:398 putative malic enzyme ((S)-malate:NAD+ oxidoreductase (decarboxylating))  ali model follow..  22  2.........................................................................................SLKNQLGQLALEQAKTFGGKLEVQPKVDIKTKHDLSIA-YTPGVASVSSAIAKDKTLAYDLTTKKNTVAVISDGTAVLGLGDIGPEAMPVMEGKAALFKAFAGVDAIPIVLDTKD------------------------------TEEIISIVKALAPTFGGINLEDISAPRCFEIEQRLIKEIPVFHDDQHGTAIVVLAAIFNSLKLLKKSLDEVSIVVNGGGSAGLSITRKLL----------AAGATKVTVVDKFGIINEQEAAQLAPHHLDIA--KVTNREFKSGTLEDALEGADIFIGVSAPGVLKAEWISKMA---ARPVIFAMANPIPEIYPDEALEAGAY---------------IVGTGRSDFPNQINNVLAFPGIFRGALDARAKTITVEMQIAAAKGIASLVPDDALSTTNIIPDAFK-EGVAEIVAKSVRSVVLKS............................................... 390
10 -79.3005cee_A mol:protein length:413 NAD-dependent malic enzyme  ali model follow..  21  2..............................................GSSSSGLVPRGSHMASMNIKE-------------KALEMHEKNKGKVGVVSKVKVQNLDDL-SLVYTPGVAEPCLKIKENPSDV-----------------YRYTMKGNMVGVITNGTAVLGLGNIGPKAS--------------------------LPVMEGKAILFKELAGIDSFPICIDSTDSQEIVNIVSKISTVF-GAINLEDIKSPQCIEIEDALKAKLDIPVFHDDQHGTAIVVAAGILNALKVVKKSIEDVQVVINGAGSAGMAIAKMLL----------LLKVNNVVLVDKTGTLYKGVANLNEPQKKLVE---VTNKYQEKGTLKEVLKGKDIFIGVSAPGIVTAEMVATM---AKDAIVFALANPVP--EIMPDEAKKGGAR-------------IVATGRSDFPNQVNNCLAFPGVFRGTLDAKATQITEEMKKAATYALKNIIKEQDLNENNILPTS-FNKEVVKQIALAVCKVAKETGVVRK.......................................... 407
11 -75.7001vl6_A mol:protein length:388 malate oxidoreductase  ali model follow..  20  1..........................................................................MGSDKIVDALEVHRFLKGKIRTALPVEKVDRETLSLLYTPGVADVARACA-----------------EDPEKTYVYTSRWNTVAVVSDGSAVLGLGNIGPYGA--------------------------LPVMEGKAFLFKAFADIDAFPICLSESEEEKIISIVKSLEPSF-GGINLEDIGAPKCFRILQRLSEEMNIPVFHDDQQGTAVVVSAAFLNALKLTEKKIEEVKVVVNGIGAAGYNIVKFLLDLGV----------KNVVAVDRKGILNENDPETCLNEYH-LEIARITNPERLSGDLETALEGADFFIGVSRGNILKPEWIKKM---SRKPVIFALANPVPEIDPELAREAGAFIV---------------ATGRSDHPNQVNNLLAFPGIMKGAVEKRSK-ITKNMLLSAVEAIARSCEPEP---ERIIPEAFDMK-VHLNVYTAVKGSA.................................................. 382
12 -74.0002hae_A mol:protein length:386 Malate oxidoreductase  ali model follow..  22  1..............................................................................MSLDALELHRFLKGKIRTALPVEKVDRETLSLLYTPGVADVARACA-----------------EDPEKTYVYTSRWNTVAVVSDGSAVLGLGNIG--------------------------PYGALPVMEGKAFLFKAFADIDAFPICLSESEEEKIISIVKSLEPSFG---GINLEDIGAPKCFRILQSEEMNIPVFHDDQQGTAVVVSAAFLNALKLTEKKIEEVKVVVNGIGAAGYNIVKFLL----------DLGVKNVVAVDRKGILNENDPE-TCLNEYHLEIARITNPERLSGDLETALEGADFFIGVSRGNILKPEWIKKM---SRKPVIFALANPVPEIDPELAREAGAF---------------IVATGRSDHPNQVNNLLAFPGIMKGAVEKRSK-ITKNMLLSAVEAIARSCEPEP---ERIIPEAFDMK-VHLNVYTAVKGSA.................................................. 378
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;