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Query: [T] KOG2290 Rhomboid family proteins, from COG1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSEARRDSTSSLQRKKPPWLKLDIPSAVPLTAEEPSFLQPLRRQAFLRSVSMPAETAHISSPHHELRRPVLQRQTSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRVADDTAEGLSAPHTPVTPGAASLCSFSSSRSGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRARRRSFTPASFLEEDTTDFPDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKAPEQADLTGGALDRSELERSHLMLPLERGWRKQKEGAAAPQPKVRLRQEVVSTAGPRRGQRIAVPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFIRSAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPIHPSAPELAGHKRQFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGKFDLYRKRCQIIIFQVVFLGLLAGLVVLFYVYPVRCEWCEFLTCIPFTDKFCEKYELDAQLHLast
1 -55.5002nr9_A mol:protein length:196 Protein glpG homolog  ali model follow..  18  11................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ITLILTALCVLIYIAQQLGFEDDIMYL-----MHYPAYEEQDSEVWRYISHTLVHLSNLHILFNLSWFFIFGGMIERTFGSVKLLMLYVVASAITGYVQNYVSG-PAFFGLSGVVYAVLGYVFIRDKLNHHLFDLPEGFFTMLLVGIALGFISPLFVEMGNAAHISGLIVGLIWGFIDSKLRKNSLELVPR........................................................ 196
2 -53.7004qnz_A mol:protein length:200 Rhomboid protease GlpG  ali model follow..  17  10................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VTWVMMIACVVVFIAMQILGDQEVMLW-----LAWPFDPTLKFEFWRYFTHALMHISLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFSG-PWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFMSMANGAHIAGLAVGLAMAFVDSLNARKRKASLERENL..................................................... 198
3 -53.3004njn_A mol:protein length:211 Rhomboid protease GlpG  ali model follow..  17  25................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VTWVMMIACVVVFIAMQILGDQEVMLW-----LAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFSG-PWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFMSMANGAHIAGLAVGLAMAFVDSLNARKRK............................................................. 205
4 -11.1004dve_A mol:protein length:198 Biotin transporter BioY  ali model follow..  13  27...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FLPGIPIGFIPVPIILQNMGIMMAGGLLGPKYGTISV-GAFLALALIG-VLTGGNGGAASFLGPSGGRIALFTPFLIGFFLKKLKITTSQNWFGELIIVLLFGVIFVDFVGAIWLSFQSNFIPGDCIKAILTVVIVRRLRKQGGFELYF................................................... 189
5 -10.4006caa_A mol:protein length:1035 Electrogenic sodium bicarbonate cotransporter 1  ali model follow..  11  1MSTENVEGKPSNLGER---------GRARSSTFLRVVQPMFNHSIFTSAVSPAAERIRFILGEEDDSPAPPQLFTELDELLAKETARWIKFEEKVEQGERWSK-ELRTCMEK-GSIMLDREASVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLRSLADIGKTVSSASRMFTNPDNGSPAMTHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRTGRFCG-GLI-----KDIKRKAPFFASDFYDALNIQ--LFIYLATVTNAITFFLGTAVSGAGPVLV------ERLLFNFSKDNNFDYLE--RLWIG-DASFLVQYFTRFTEIYDAFKKMIKLADYYPINSNFKVGYNTLFSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGNLVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWFVPPFGENPWWVCLAAALLVTILIFMDQQITAVIVNRKELKKGAGYFWVAILMVICSLMAHIDSLKMETETSAPGEQPKFLGVVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGV-------ASLNGFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWI................................... 922
6 -10.0005jki_A mol:protein length:222 Putative lipid phosphate phosphatase YodM  ali model follow..  8  14................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNEVMTGITHL----GASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDLLNKVLKEWIERVRPDF-PSGCVYPVIAYFLVKHLPF-----LSKHKKMVYIIAGVIAVLVGI-SRVYLGVHLGGFSLGLLLFFLVKGFDEKIKRFRQK........................................................ 216
7 -9.8803b4r_A mol:protein length:224 Putative zinc metalloprotease MJ0392  ali model follow..  16  47...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LFVSVVLHE-LGH----SYVAKKYGVKIEKI-------LLLPIGGVA---MDKIPKEGELRIGIAGPLVSFIIGIVLLIVSQFFDININGYPLLYTLSLLNLMLGFNLIPAFP----MDG---GRILRAILSKKYGYLKSTKIAANIGKSLALIMLLFIILILVSLF................................. 199
8 -8.9904fc4_A mol:protein length:261 Nitrite transporter NirC  ali model follow..  12  58..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PLVMGATFGIALTLVIITMFLTLGVKAGTISHGQMWAILPQTWLGNLVGSVFVALLYSWGGGSLLPVDFKGALCNWLVCLAIWMAIRTEGTAKFLAIWWCLLAFIASGYEHSVANMVTLGNTLSGVVFMGLGYWYATPKSELE.......................................................... 255
9 -8.8904yzf_A mol:protein length:911 Band 3 anion transport protein  ali model follow..  9  1...........MEELQDDYEDMMEENLEQEEYEDPDIPESQMEEPAAHDTEATATDYHTTSHPGTHELQELVMDEKNQELRWMEAARWVQLEENLGENGAWGRPHLSHLTTSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAGELEALGGVKPAVLTRSGDPSQPLLPQHSSLETQLFCEQGDGGTEGHSPSGILEKIPPDSEATLVLVGRADFLEQGFVRLQEAAELEAVELPVPIRFLFVLLGPEAPHIDYTQLGRA------ATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYKGLDLNGGPDDPLQQT-----------GQLFGGLVRDIRRRYPYYLSDITDAFSPQ--IFIYFAALSPAITFLISTAVQGIGPLLV------EEAFFSFCETNGLEYIV--RVWIG-EGSFLVRFISRYTQIYETFSKLIKIFQDHPLQKTYNYNVLMVPKPQGPLPNTALLSLVLMAGTFFFA--------------------------------------------MMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRSEFPIWMMFASALPALLVFILIFLESQITTLIVSKPEMVKGSGFLLVVGMGGVAALFGHANALTVMGKASTPGAAAQIQEVISGLLVAVLVGLSILMEPILSRIPLAVLFGIFLYMGV-------TSLSGLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQ 884
10 -8.8704hzu_S mol:protein length:166 Predicted membrane protein  ali model follow..  11  3..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KGSLKENTIAAVL-IAMTVALSILVVIPIPATKGIVTLVGIYTSAILYGRR--------------MGLLVGGASGFLIDILTGYPV----------------------WCLFSLVIHGTQGLVVGWLL--------PRHHKGIRSMLLPLLVGSLVMVIGYCLATTLLF................................ 128
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;