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Query: [S] KOG2632 Rhomboid family proteins, from COG1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRPNIVTEAGVQTRVGQWWNAIPFLTSSVVVVCGVIYLICLLTGYDTFYEVCFLPSAIISRFQVYRFYTAIIFHGSLLHVLFNMMALVPMGSELERIMGSVRLLYLTVLLATTNAVLHLLIASLAGYNPFYQYDHLMNECAIGFSGILFSMIVIETSLSGVTSRSVFGLFNVPAKLYPWILLIVFQLLMTNVSLLGHLCGILSGFSYSYGLFNFLMPGSSFFTTIESASWMLIVTHPVSMSSSSLASLGDPSSLCVLAGILPAIFPLILHKTQHPGNAWRSLSSWLPQREASNQSSEDSRFPGRGRTLSTARDPTAPAGETDPNLHARLLEDSSSPDRLSDATVNTVADSRQAPIANAAVLPQSQGRVAASEEQIQKLVAMGFDRTQVEVALAAADDDLTVAVEILMSQQVLast
1 -57.9004qnz_A mol:protein length:200 Rhomboid protease GlpG  ali model follow..  18  1...............AALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHISLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFS---------------GPWFGGLSGVVYALMGYVWLRGERDPQSGIYL-GLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAMAFVD........................................................................................................................................................................................................ 182
2 -57.0002nr9_A mol:protein length:196 Protein glpG homolog  ali model follow..  18  1..............MENFLAQQGKITLILTALCVLIYIAQQLGFEDDIMYLMHYPAYEEQDSEVWRYISHTLVHLSNLHILFNLSWFFIFGGMIERTFGSVKLLMLYVVASAITGYVQNYVS---------------GPAFFGLSGVVYAVLGYVFIRDKLNHHLFDLPEGFFTMLLVGIALFISPLFGVEMGNAAHISGLIVGLIWGFIDSKLRKNSLELVPR........................................................................................................................................................................................... 196
3 -56.3004njn_A mol:protein length:211 Rhomboid protease GlpG  ali model follow..  17  1MGSSSSGLVPRGSHMAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFS---------------GPWFGGLSGVVYALMGYVWLRGERDPQSGIYL-GLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAMAFVD........................................................................................................................................................................................................ 197
4 -22.9001vg5_A mol:protein length:73 rhomboid family protein  ali model follow..  89  2.......................................................................................................................................................................................................................................................................................................................................................SSGSSGSRQAPIANAAVLPQSQGRVAASEEQIQKLVAMGFDRTQVEVALAAADDDLTVAVEILMSQS. 68
5 -21.8001veg_A mol:protein length:83 NEDD8 ultimate buster-1  ali model follow..  22  1......................................................................................................................................................................................................................................................................................................................................................GSSGSSGNPHMWWLQDADPENNSRQASPSQESINQLVYMGFDTVVAEAALRVFGGNVQLAAQTLAHHG. 68
6 -21.3002cwb_A mol:protein length:108 chimera of Immunoglobulin G binding protein G and Ubiquitin-like protein SB132  ali model follow..  13  2........................................................................................................................................................................................................................................................................................................................QYKLALNGKTLKGETTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTEGSQWQPQLQQLRDMGIDDELSLRALQATGGDIQAALELIFAG.. 99
7 -19.8002qsf_X mol:protein length:171 UV excision repair protein RAD23  ali model follow..  16  90..........................................................................................................................................................................................................................................................................................................................................MEGADDMVEGEDIEVTGEAAAAGLGQGEGEGSFQVDYTPEDDQAISRLCELGFERDLVIQVYFACDKNEEAAANILFSDH. 169
8 -19.7001wiv_A mol:protein length:73 ubiquitin-specific protease 14  ali model follow..  14  1......................................................................................................................................................................................................................................................................................................................................................GSSGSSGLLSHMDDPDIDAPISHQTSDIDQSSVDTLLSFGFAEDVARKALKASGGDIEKATDWVFNN.. 67
9 -19.7002dai_A mol:protein length:83 Ubiquitin associated domain containing 1  ali model follow..  16  2.......................................................................................................................................................................................................................................................................................................................................................SSGSSGDAVELFKKANAMLDEDEDERVDEAALRQLTEMGFPENRATKALQLNHMSVPQAMEWLIEHA. 68
10 -19.5001vej_A mol:protein length:74 RIKEN cDNA 4931431F19  ali model follow..  25  2.......................................................................................................................................................................................................................................................................................................................................................SSGSSGARACSQSSQTALPTSLFTEGRYQQELEELKALGFNRDANLQALVATDGDIHAAIEMLLGAS. 69
11 -18.2001wgn_A mol:protein length:63 ubiquitin associated protein  ali model follow..  12  2.................................................................................................................................................................................................................................................................................................................................................................SSGSSGAYSELQMLSPSERQCVETVVNMGYSYECVLRAMKKKGENIEQILDYLFAH.. 57
12 -18.1002lbc_A mol:protein length:126 Ubiquitin carboxyl-terminal hydrolase 13  ali model follow..  25  41.............................................................................................................................................................................................................................................................................................................................................VHMEEPDFAEPLTMPGYGGAASAGASVFGASGLDNQPPEEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSHP. 117
13 -18.0002dak_A mol:protein length:63 Ubiquitin carboxyl-terminal hydrolase 5  ali model follow..  34  2...........................................................................................................................................................................................................................................................................................................................................................................SSGSSGPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSH.. 47
14 -17.9001wji_A mol:protein length:63 Tudor domain containing protein 3  ali model follow..  23  2...........................................................................................................................................................................................................................................................................................................................................................................SSGSSGVDEKALKHITEMGFSKEASRQALMDNGNNLEAALNVLLTSN. 48
15 -17.5001wr1_B mol:protein length:58 Ubiquitin-like protein DSK2  ali model follow..  22  4.....................................................................................................................................................................................................................................................................................................................................................................SGGGGGILDPEERYEHQLRQLNDMGFDFDRNVAALRRSGGSVQGALDSLLNGDV 58
16 -17.4002dna_A mol:protein length:67 unnamed protein product  ali model follow..  26  2.................................................................................................................................................................................................................................................................................................................................................................SSGSSGPSHSLQAPEVRFSKEMECLQAMGFNYNANLQALIATDGDTNAAIYKLKSSQ. 59
17 -16.9002juj_A mol:protein length:56 E3 ubiquitin-protein ligase CBL  ali model follow..  20  1............................................................................................................................................................................................................................................................................................................................................................................ATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILRE... 44
18 -16.7002oo9_A mol:protein length:46 E3 ubiquitin-protein ligase CBL  ali model follow..  23  4..................................................................................................................................................................................................................................................................................................................................................................................LSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILRE... 41
19 -16.7004ae4_A mol:protein length:118 UBIQUITIN-ASSOCIATED PROTEIN 1  ali model follow..  15  45...................................................................................................................................................................................................................................................................................................................................................AHGQLCEKGFDPLLVEEALEMHQCSEEKMMEFLQLMSKFKEMGFELKDIKEVLLLHNNDQDNALEDLMARA. 115
20 -16.6001vek_A mol:protein length:84 ubiquitin-specific protease 14, putative  ali model follow..  17  2.......................................................................................................................................................................................................................................................................................................................................................SSGSSGGEELLPDGVPEEVMESAQPVANEEIVAQLVSMGFSQLHCQKAAINTNAGVEEAMNWLLSHM. 69
21 -16.5002mr9_A mol:protein length:44 DNA damage-inducible protein 1  ali model follow..  27  1.............................................................................................................................................................................................................................................................................................................................................................................GSATFPEQTIKQLMDLGFPRDAVVKALKQTNGNAEFAASLLFQS.. 44
22 -16.4002dag_A mol:protein length:74 Ubiquitin carboxyl-terminal hydrolase 5  ali model follow..  27  2...........................................................................................................................................................................................................................................................................................................................................................................SSGSSGLDESVIIQLVEMGFPMDACRKAVYYTNSGAEAAMNWVMSHM. 49
23 -15.9002cpw_A mol:protein length:64 Cbl-interacting protein Sts-1 variant  ali model follow..  21  2.................................................................................................................................................................................................................................................................................................................................................................SSGSSGRNRQQRPGTIKHGSALDVLLSMGFPRARAQKALASTGRSVQTACDWLFSHS. 59
24 -15.8002g3q_A mol:protein length:43 Protein YBL047C  ali model follow..  23  1...............................................................................................................................................................................................................................................................................................................................................................................TTPKSLAVEELSGMGFTEEEAHNALEKCNWDLEAATNFLLDSA. 43
25 -15.6002knz_A mol:protein length:53 Ubiquilin-4  ali model follow..  30  1........................................................................................................................................................................................................................................................................................................................................................................GPLGSMPEVRFQQQLEQLNSMGFNREANLQALIATGGDINAAIERLLGSQ. 51
26 -15.4002jy5_A mol:protein length:52 Ubiquilin-1  ali model follow..  31  1.......................................................................................................................................................................................................................................................................................................................................................................GSPEFQNPEVRFQQQLEQLSAMGFNREANLQALIATGGDINAAIERLLGSS. 52
27 -15.4002d9s_A mol:protein length:53 CBL E3 ubiquitin protein ligase  ali model follow..  24  2...........................................................................................................................................................................................................................................................................................................................................................................SSGSSGQLSSEIERLMSQGYSYQDIQKALVIAHNNIEMAKNILRE... 46
28 -15.3002ooa_A mol:protein length:52 E3 ubiquitin-protein ligase CBL-B  ali model follow..  25  1........................................................................................................................................................................................................................................................................................................................................................................GSGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILRE... 48
29 -15.3001dv0_A mol:protein length:47 DNA REPAIR PROTEIN HHR23A  ali model follow..  30  1...............................................................................................................................................................................................................................................................................................................................................................................GSQEKEAIERLKALGFPESLVIQAYFACEKNENLAANFLLSQ.. 42
30 -14.9002do6_A mol:protein length:53 E3 ubiquitin-protein ligase CBL-B  ali model follow..  30  1..........................................................................................................................................................................................................................................................................................................................................................................GSSGSSGNVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILRE... 46
31 -14.9001whc_A mol:protein length:64 UBA/UBX 33.3 kDa protein  ali model follow..  31  2...........................................................................................................................................................................................................................................................................................................................................................................SSGSSGAELTALESLIEMGFPRGRAEKALALTNQGIEAAMDWLMEHE. 49
32 -14.9001f4i_A mol:protein length:45 UV EXCISION REPAIR PROTEIN PROTEIN RAD23 HOMOLOG A  ali model follow..  33  2..................................................................................................................................................................................................................................................................................................................................................................................EKEAIERLKALGFEESLVIQAYFACEKNENLAANFLLSQ.. 40
33 -14.8001z96_A mol:protein length:40 UBA-domain protein mud1  ali model follow..  43  4..................................................................................................................................................................................................................................................................................................................................................................................LNSKIAQLVSMGFDPLEAAQALDAANGDLDVAASFLL.... 40
34 -14.7001oqy_A mol:protein length:368 UV excision repair protein RAD23 homolog A  ali model follow..  16  254......................................................................................................................................................................................................................................................................................................QQNPALLPALLQQLGQENPQLLQQISRHQEQFIQMLN-----EPPGELADISDVEGEVGAIGEEAPQMNYIQVTPQEKEAIERLKALGFPESLVIQAYFACEKNENLAANFLLSQN. 364
35 -14.6002crn_A mol:protein length:64 UBASH3A protein  ali model follow..  29  2...........................................................................................................................................................................................................................................................................................................................................................................SSGSSGSSPSLLEPLLAMGFPVHTALKALAATRKTAEEALAWLHDHC. 49
36 -14.5002dkl_A mol:protein length:85 Trinucleotide Repeat Containing 6C Protein  ali model follow..  23  2...............................................................................................................................................................................................................................................................................................................................................................SSGSSGGMKTSGKQDEAWIMSRLIKQLTDMGFPREPAEEALKSNNMNLDQAMSALLEKKV 61
37 -14.5002dah_A mol:protein length:54 Ubiquilin-3  ali model follow..  33  1..........................................................................................................................................................................................................................................................................................................................................................................GSSGSSGHFQVQLEQLRSMGFNREANLQALIATGGDVDAAVEKLRQSS. 49
38 -14.4004un2_B mol:protein length:48 UBIQUITIN DOMAIN-CONTAINING PROTEIN DSK2  ali model follow..  25  1............................................................................................................................................................................................................................................................................................................................................................................GSPEERYEHQLRQLNDMGFDFDRNVAALRRSGGSVQGALDSLLNGDV 48
39 -14.0002ekk_A mol:protein length:47 UBA domain from E3 ubiquitin-protein ligase HUWE1  ali model follow..  30  1..........................................................................................................................................................................................................................................................................................................................................................................GSSGSSGVNQQQLQQLMDMGFTREHAMEALLNT-STMEQATEYLLTH.. 46
40 -13.8002cos_A mol:protein length:54 Serine/threonine protein kinase LATS2  ali model follow..  23  2...........................................................................................................................................................................................................................................................................................................................................................................SSGSSGVNRQMLQELVNAGCDQEMAGRALKQTGSSIEAALEYISKMS. 49
41 -13.6001wj7_A mol:protein length:104 Hypothetical protein (RSGI RUH-015)  ali model follow..  16  1............................................................................................................................................................................................................................................................................................................................................GSSGSSGNQNQTQHKQRPQATAEQIRLAQMISDHNDADFEEKVKQLIDIGKNQDECVIALHDCNGDVNRAINVLLEGNP 80
42 -13.6005nnr_C mol:protein length:133 HypK  ali model follow..  9  1.............................................................................................................................................................................................................................................................................................MGAAEDRQPADIVEGATAGDVEEEVAPAAKSAEDRKAAAALSKLDAHADEDMAPAREVDQEAVKNAMSALSGASTEKKEVKKVKVDPADVNLLVELELSKAKATELLKAHDGDAIKAMKAYIQPAF 127
43 -12.4004bj5_C mol:protein length:202 DNA-BINDING PROTEIN RAP1  ali model follow..  9  1......................................................................................................................................................................................................................................................................GASNSYAIPENELLDEDTMNFISSLKNDLSNISNSLPFEYPHEIAEAIRSDFSNEDIYDNIDPDTISFPPKIATTDLFLPLFFHFGSTRQFMDKLHEVISGDYEPSQAEKLVQDLCDETGIRKNFSTSILTCLSGDLMVFPRYFLN... 146
44 -12.0002mgw_A mol:protein length:52 Next to BRCA1 gene 1 protein  ali model follow..  18  1.........................................................................................................................................................................................................................................................................................................................................................................GPLGSSEDQTAALMAHLFEMGFDRQLNLRLLKKHNYNILQVVTELLQLN. 50
45 -11.9006c95_D mol:protein length:129 Huntingtin-interacting protein K  ali model follow..  11  10.................................................................................................................................................................................................................................................................................................ATEGDVELELETETSGPERPPEKPRKHDSGAADLERVTDYAEEKEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMEMEISRAAAERSLREHMGNVVEALIALTN... 129
46 -11.3003cz6_A mol:protein length:168 DNA-binding protein RAP1  ali model follow..  11  1........................................................................................................................................................................................................................................................................................................................GAIRSDFSNEDIYDNIDPDTISFPPKIATTDLFLPLFFHFGSTRQFMDKLHEVISGDYEPSQAEKLVETGIRKNFSTSILTCLSGDLMVFPRYFLN... 101
47 -11.0002cp8_A mol:protein length:54 Next to BRCA1 gene 1 protein  ali model follow..  23  2...........................................................................................................................................................................................................................................................................................................................................................................SSGSSGQTAALMAHLFEMGFDRQLNLRLLKKHNYNILQVVTELLQLS. 49
48 -10.6001q02_A mol:protein length:52 sequestosome 1  ali model follow..  14  1.........................................................................................................................................................................................................................................................................................................................................................................GSPPEADPRLIESLSQMLSMGFSDEGLTRLLQTKNYDIGAALDTIQYSK. 51
49 -10.6002rru_A mol:protein length:53 Sequestosome-1  ali model follow..  16  2.........................................................................................................................................................................................................................................................................................................................................................................PLGSEADPRLIESLSQMLSMGFSDEGLTRLLQTKNYDIGAALDTIQYSK. 52
50 -10.2002lva_A mol:protein length:129 Ubiquitin carboxyl-terminal hydrolase 28  ali model follow..  22  2.....................................................................................................................................................................................................................................................................................................................................................................SSGRENLYFQGQMLLNQLREI--TGIDPSFLHEALKASNGDITQAVSLLTDERV 54
51 -9.9201vdl_A mol:protein length:80 Ubiquitin carboxyl-terminal hydrolase 25  ali model follow..  18  2.........................................................................................................................................................................................................................................................................................................................................................SSGSSGMTVEQNVLQQSAAQKHQQTFLNQLREIT--GINDAQIQQALKDSNGNLELAVAFLTAKNA 66
52 -9.7901ufz_A mol:protein length:83 Hypothetical protein BAB28515  ali model follow..  10  1..............................................................................................................................................................................................................................................................................................................................................GSSGSSGEYGYEDLRESSNSLLNHQLSEIDQARLYSCLDHMREVLGDAVPDDILTEAILKHKFDVQKALSVVLEQD. 76
53 -9.7102cp9_A mol:protein length:64 Elongation factor Ts, mitochondrial  ali model follow..  28  2...........................................................................................................................................................................................................................................................................................................................................................................SSGSSGSSKELLMKL-KTGYSFVNCKKALETCGGDLKQAEIWLHKE.. 48
54 -9.4104dbg_B mol:protein length:162 RING finger protein 31  ali model follow..  16  76........................................................................................................................................................................................................................................................................................................................................................SCQEARRAWLDRHGNLDEAVEECVRTRRRKVQELQSLGGPEEGSLQALFQHGGDVSRALTELQRQRL 143
55 -9.3102muu_A mol:protein length:137 Ubiquitin carboxyl-terminal hydrolase 28  ali model follow..  20  6..............................................................................................................................................................................................................................................................................................................................................................ELQQDDAAGAADGHGSSCQMLLNQLREIT--GIQDPSFHEALKASNGDITQAVSLLTDERV 65
56 -9.2705x0w_A mol:protein length:166 E3 ubiquitin-protein ligase RNF31  ali model follow..  16  77........................................................................................................................................................................................................................................................................................................................................................SCQEARRAWLDRHGNLDEAVEECVRTRRRKVQELQSLGGPEEGSLQALFQHGGDVSRALTELQRQRL 144
57 -9.2605y3t_B mol:protein length:158 E3 ubiquitin-protein ligase RNF31  ali model follow..  14  72........................................................................................................................................................................................................................................................................................................................................................SCQEARKAWLDRHGNLDEAVEECVRARRRKVHELQSLGGPKEGSLQALFQHGGDVARALTELQRQRL 139
58 -9.2402dhy_A mol:protein length:67 CUE domain-containing protein 1  ali model follow..  16  1.................................................................................................................................................................................................................................................................................................................................................................GSSGSSGRPARQVRRLEFNQAMDDFKTMNMDYDIIECVLRANSGAVDATIDQLLQ... 57
59 -9.2005fyw_Q mol:protein length:735 TRANSCRIPTION INITIATION FACTOR IIF SUBUNIT ALPHA  ali model follow..  5  547..............................................................................................................................................................................................................................................LYSSDENEINPYLSESDIENKENESPVKKEEDSDTLSKSKRSSPKKQQKKATNAHVHKEPTLRVKSIKNCVIILKGDKKILKSFPEGEWNPQTTKAVDSSNNASNTVPSPIKQEEGLNSTVAEREETPAPTITEKDIIEIGDGKVNIKEFGKFIRRGAENKKLMFAIV--KKL 721
60 -9.0905oqm_Q mol:protein length:747 Transcription initiation factor IIF subunit alpha  ali model follow..  5  560...............................................................................................................................................................................................................................................YSSDENEINPYLSESDIENKENESPVKKEEDSDTLSKSKRSSPKKQQKKATNAHVHKEPTLRVKSIKNCVIILKGDKKILKSFPEGEWNPQTTKAVDSSNNASNTVPSPIKQEEGLNSTVAEREETPAPTITEKDIIEIGDGKVNIKEFGKFIRRGAENKKLMFAIV--KKL 733
61 -9.0801tr8_A mol:protein length:102 conserved protein (MTH177)  ali model follow..  21  51....................................................................................................................................................................................................................................................................................................................................................................GKARERSLEAEMEIPEDDIELVMNQGASREDATRALQETGGDLAEAIMRLS.... 102
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Wyrwicz LS, Godzik A, Kloczkowski A, Rychlewski L. Support-vector-machine classification of linear functional motifs in proteins. J Mol Model 2006 Aug;12(4):453-61. Epub 2005 Dec 10.