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Query: [I] KOG2833 Mevalonate pyrophosphate decarboxylase, from COG1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MATEKWVFMVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMWLNGKEISLSGSRYQNCLREIRGRAGDVEDMEKGIKIRKKDWEKLNLHIASHNNFPTAAGLASSAAGFACLVFSLAKLMNVDEDPSHLSAIARQGSGSACRSLFGGFVKWTMGSKEDGSDSVAVQLADEKHWDDLVIIIAVETSSTSGMRESVETSLLLQHRAKEVVPKRILQMEEAIKNRDFASFTQLTCTDSNQFHAVCLDTSPPIFYMNDTSHRIISLVEKWNRSEGTPQVAYTFDAGPNAVLIARNRKVAVQLLQGLLYYFPPKSDTDMKSYVVGDNSILKEAGLDGASGVENLQPPPEIKDNIGSQDQKGEVSYFICTRPGKGPIVLHDQTQALLDPETGLPKLast
1 -118.0003d4j_A mol:protein length:400 Diphosphomevalonate decarboxylase  ali model follow..  49  1MASEKPLAAVTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDFTEDRIWLNGREEDVGQPRLQACLREIRCLARKRRNSR--DGDPLPSSLSCKVHVASVNNFPTAAGLASSAAGYACLAYTLARVYGVE---SDLSEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQVAPESHWPELRVLIKKLTGSTVGMRASVETSPLLRFRAESVVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNAHHGDTKVAYTFDAGPNAVIFTLDDTVAEF-VAAVWHGFPPGSNGDTFLKG---------------LQVRPAPLSAELQAALAMEPTPGGVKYIIVTQVGPGPQILDDPCAHLLG-PDGLPK 397
2 -113.0003f0n_A mol:protein length:414 MEVALONATE PYROPHOSPHATE DECARBOXYLASE  ali model follow..  50  10.FQGPQDLMVTCTAPVNIAVIKYWGKRDEALILPINSSLSVTLHQDQLKTTTTVAISKDFTEDRIWLNGREEDVGQPRLQACLREIRRLARKRRSTEDGD--TLPLSLSYKVHVASVNNFPTAAGLASSAAGYACLAYTLAQVYGVE---GDLSEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQIAPEWHWPQLRILIKKQTGSTVGMQTSVETSTLLKFRAESVVPERMKEMTRCIQEQDFQGFAQLTMKDSNQFHATCLDTFPPISYLNDTSRRIIQLVHRFNTHHGQTKVAYTFDAGPNAVIFTLEDTVAEF-VAAVRHSFPPAANGDKFLKG---------------LQVAPVLLSDELKAALVVEPSPGGVQYIIATQVGPGPQVLDDTHDHLLG-QDGLPQ 405
3 -110.0001fi4_A mol:protein length:416 MEVALONATE 5-DIPHOSPHATE DECARBOXYLASE  ali model follow..  44  12.GSHMTVYTASVTAPVNIATLKYWGKRDTKLNLPTNSSISVTLSQDDLRTLTSAATAPEFERDTLWLNGEPHSIDNERTQNCLRDLRQLRKEMES----KDASLPTLSQWKLHIVSENNFPTAAGLASSAAGFAALVSAIAKLYQLPQSTSEISRIARKGSGSACRSLFGGYVAWEMGKAEDGHDSMAVQIADSSDWPQMKACVKKDVSSTQGMQLTVATSELFKERIEHVVPKRFEVMRKAIVEKDFATFAKETMMDSNSFHATCLDSFPPIFYMNDTSKRIISWCHTINQFYGETIVAYTFDAGPNAVLYYLAENESKL-FAFIYKLFGSV------------PGWDKKFTTEQLEAFNHQFESSNFTARELDLELQKDVARVILTQVGSGPQETNE---SLIDAKTGLPK 409
4 -109.0002hke_A mol:protein length:380 Diphosphomevalonate decarboxylase, putative  ali model follow..  36  1MSDQ----CVTVEAPINIAFIKYWGKREETLILPTNDSFSITLSASPFRSKTSVELRDDIETDTLRLNGTEVDGKTPRVQSMLLHLRSTCPEELK-------------NKKVNIVSENNFPTAAGMASSASGYCAMSAALIRAFK---STTNVSMLARLGSGSACRSAFGGFVIWNKGEKPDGSDCVATQFVDETHWPEIQVMCQKDVSSTKGMQQSLKTSPLMKKRISETVPERMKIASRAIKARDFATFAEIAMLESDDLQEICATTEPKITYATEDSYAMIRLVKAYNAKKGRTALAYTFDAGANCFLFVLKEDLPEA-VAMLMEHFPTP------------FEKFFFGDRELLEKVKVVSLPDEYKKLI--DHPKKPFEMLLQSPVGCGVKYL-GPSESLIPP...... 380
5 -88.5005W1P Entity 1(prereleased)  ali follow..  17  43.PDIKYNKTFHANGYPITGLYKFLGYYDRDNNIANFPSISFTTNFSSCDVTCRVL---RSGNDRIIFNGKNNEKYYKRAEKALSFLRKKYRIDAAF--------------EFNIRINRRYRDAKGLGESAAVASATARAVAAAVDAAKDRGFVSYLARHVSGSGTRSAAGNLSMWLSYPGIDDLSSIGFEIRKDDLFH-FYAIPMRSRIETLNAHDYASSSIFYNAWVKSKFFD---IIDIIENKFNTRMMLEYSMKDMYRLQALLISSGYI--IYEKHYLDIIRKLRSS--LNNYKNVYFTSDTGTSIVVMSTSMNELSRFVNDL....................................................................................... 345
6 -82.2004rkp_A mol:protein length:337 Putative uncharacterized protein Ta1305  ali model follow..  15  11.RGSMTYRSIGSTAYPTIGVVLLGGIANPVTRTPLHTSAGIAYSDSCGSIRSETRIYAD-EATHIYFNGTESTDDNRSVRRVLDRYSSVFEE----------------AFGTKTVSYSSQNFGILSGSSDAGAASIGAAILGL-KPDLDPHDVENDLRAVSESAGRSLFGGLTITWSD----GFHAYTEKILDPEAFSGYSIVADYQRNPSDVIHQNIVRSDLYPARKKHA-DEHAHMIKEYAKTNDIKGIFDLAQEDTEEYHSILRGVGVN--VIRENMQKLISYLKLIRKD-----NAYIVTGGSNVYVAVESENADRLF--SIENTFGSKKKMLRIVGGAWHRRP................................................................. 330
7 -79.0003lto_A mol:protein length:323 Mevalonate diphosphate decarboxylase  ali model follow..  24  1.......MHWFAQAPANIALIKYMGKKDENSNLPDNSSLSYTLSNLLSSVKLEKLPTKKDIWEPLTIPGAPEFNLSVEAQKRFIDHLVRL------------KEYFGYVGGFLIQSSNNFPHSSGLASSASSFAALTKCASIALSELPSIDEQAQLSRLGSGSSCRSFYAPWALWTGDKVSAIDLPY-----KDLLHQVIVISSQEKEIPSRVAHKLVKTSPFYETRSERA-EANLKLLLNAFENKDWTSIYQICWHEFLDMHQLFKTCEKPFSYITDNTLHILSVIEKF-WNEKGDGPVVTMDAGPNVHLLYRSDQTDL-ARQFKSDHLVGNYDVLE........................................................................... 316
8 -73.6005v2l_A mol:protein length:334 Mevalonate diphosphate decarboxylase  ali model follow..  30  1...SNAMLSGKARAHTNIALIKYWGKANEEYILPMNSSLSLTLD--AFYTETTVTFDAHYSEDVFILNGILQNEKQTKKVKEFLNLVRQQAD---------------CTWFAKVESQNFVPTAAGLASSASGLAALAGACNVALGLNLSAKDLSRLARRGSGSACRSIFGGFAQWNKGHSDETSFAENIPANNWENELAMLFILEKDVSSRDGMKRTVETSSFYQGWLDNV-EKDLSQVHEAIKTKDFPRLGEIIEANGLRMHGTTLGAVPPFTYWSPGSLQAMALVRQA--RAKGIPCYFTMDAGPNVKVLVEKKNLEA-LKTFLSEHFSKEQ--------------------------------------------------LVPAFAGPGIELFETKGMD.......... 333
9 -70.5005gmd_A mol:protein length:325 Diphosphomevalonate decarboxylase  ali model follow..  39  1.....MLKSVTVSAPSNIAVVKYWGKRDERLNLPLNNSLSITLD--DQLSVITKVTLNDKNIVIVNDRILSEDEMKEYAGRVLDTFKKIVGK----------------EFHVKVESKSKFPINAGLASSAAGIAALAFSLNELLELNLKSEELSKIARLGSGSACRSMFGGFVVWNKGEREDGEDSYCYQIFRHDYWSELVDIIEKKISSRKGMIRSAETSELMECRLKYI-EKTFNEVIEAIRNRDEKKFYYLMMRHSNSMHAVILDSWPSFFYLNDTSIRIMEWIHDYGK------AGYTFDAGPNPHIFTTERNIGDILEFLKSL----------------------------------------------------EIKRIIVSKVGDGPKVLSRE............. 325
10 -69.4002gs8_A mol:protein length:317 mevalonate pyrophosphate decarboxylase  ali model follow..  23  1.SNAMDPNVITVTSYANIAIIKYWGKENQAKMIPSTSSISLTLENMFTTTSVSFLPDTATSDQFYINGILQNDEEHTKISAIIDQFRQPG------------------QAFVKMETQNNMPTAAGLSSSSSGLSALVKACDQLFDTQLDQKALAQKAKFASGSSSRSFFGPVAAWDKDSGAIYKVETDLKM---AMIMLVLNAAKKPISSREGMKLCRDTSTTFDQWVEQS-AIDYQHMLTYLKTNNFEKVGQLTEANALAMHATTKTANPPFSYLTKESYQAMEAVKEL--RQEGFACYFTMDAGPNVKVLCLEKDLAQ-LAERLGKNYR-----------------------------------------------------IIVSKTKDLPDV................. 317
11 -67.6002hk2_A mol:protein length:331 Diphosphomevalonate decarboxylase  ali model follow..  30  2ML--EMIKSGKARAHTNIALIKYWGKKDEALIIPMNNSISVTLE--KFYTETKVTFNDQLTQDQFWLNGEKVSKELEKISKYMDIVRNRAGI----------------DWYAEIESDNFVPTAAGLASSASAYAALAAACNQALDMQLSDKDLSRLARIGSGSASRSIYGGFAEWEKGYSDETSYAVPLESNHFEDDLAMIFVVSKKVPSRYGMSLTRNTSRFYQYWLDHI-DEDLAEAKAAIQDKDFKRLGEVIEENGLRMHATNLGSTPPFTYLVQESYDVMALVHEC--REAGYPCYFTMDAGPNVKILVEKKNKQQ-IIDKLLTQFDNNQIIDSDIIATGIEII................................................................. 330
12 -63.1003qt5_A mol:protein length:332 Mevalonate diphosphate decarboxylase  ali model follow..  33  2STGS-MVKSGKARAHTNIALIKYWGKADETYIIPMNNSLSVTLD--RFYTETKVTFDPDFTEDCLILNGNEVNKEKEKIQNYMNIVRDLAGN----------------RLHARIESENYVPTAAGLASSASAYAALAAACNEALSLNLSDTDLSRLARRGSGSASRSIFGGFAEWEKGH--DDLTSYAHGINSNGWEKDLSMIFSKKVSSRSGMSLTRDTSRFYQYWLDHV-DEDLNEAKEAVKNQDFQRLGEVIEANGLRMHATNLGAQPPFTYLVQESYDAMAIVEQC--RKANLPCYFTMDAGPNVKVLVEKKNKQAV-MEQFLKVFDESKIIASDIISSGVEII................................................................. 331
13 -17.6003k17_A mol:protein length:365 Lin0012 protein  ali model follow..  11  1MSLKN---KLQVKIPGKLYVA---G--EYAVVESGHTAILTAVN---RYITLTLEDSERNELWIPHYENPVSWPIGGELKPDGEHWTFTAEAINIATTFLKSEGIELTPVKMVIETEDQSGAKYGLGSSAAATVAVINALMTKFYPEISMLKKFKLAALGNGSCASCMYGGWIAYTTFDQEWVKPMLQIETLEEPVPTFSVGWTGTPVSTGKQIHAFKQEDSKNYQHFLTRNNEIMKQIIQAFHTKDEELLYSSIKENRRILQELGTKAGVNI------ETSLLKELADSAENMGGAGKSSGSGGGDCGIAFSKTKELAEKLVNEWEKL.................................................................................... 342
14 -17.3001fwk_A mol:protein length:296 HOMOSERINE KINASE  ali model follow..  15  1.......MKVRVKAPCTSANL------------VGFDVFGLCLKEPYDVIEVEAI-----DDKEIIIEVDDKNIPTDPDKNVAGIVAKKM------------IDDFNIGKGVKITIKKGVKAGSGLGSSAASSAGTAYAINELFKLNLDKLKLVDYASYGEDNVAPAIFGGFTM-----VTNYEPLEVLHIPIDFKLD-ILIAIPNISINTKEAREILPKAVGLKDLVNNV--GKACGMVYALYNKDKSLFGRYMMSDK---------------VIEPVRGKLIPNYFKIKEEVKDKVYGITISSGPSIIAFPKEEFIDEV............................................................................................ 273
15 -17.0004p52_A mol:protein length:331 Homoserine kinase  ali model follow..  13  12LYFQSMKDSIKVFAPATVANV------------CGFDVLGFAVDNPGDEVLLRLSDKKGVRITSITGDDGRLPKDAEKVSISILRYLETLGI----------------EQGIEIELTKKMPLGSGLGSSAASTVAGVYAINQLLGNKMEVKDLLPFAFLACGSAAPCLYGGFVL-----VRSYDPLDVVKLPVPANLY-ATIIHPHVEVQTKDARNILPKQIALSQAVAQW--GNVGGLVAGLLMNDTSLIGRSMQDH----------------IVEPARSVLIPGFDDVKKLDAGALGCSISGSGPSIFALSTSQEAAQKIGQAMKKGFDA................................................................................. 305
16 -16.7003hul_A mol:protein length:298 Homoserine kinase  ali model follow..  15  1.......MSLRIRVPATTANL------------PGFDSCGLALT---LYLTLDIGAEADSWYIEHNIGGGIPHDETNVIIETALNLAPNLT-------------------PHHLVMTCDIPPARGLGSSSAAVVAGIELANTLAELNLSKEEKVRIAAEIEGNVAPAVLGNWVV------GAKLDGEDFYVRHLFPDCALIAFIPKAELLTSESRGVLPDTLPFKEAVQAS--SIANVMIAAILRNDMTLAGEMMERD--LWH-------------EKYRSQLVPHLAQIRDKNQGAYAACLSGAGPTVLVFAPRNLANKL............................................................................................ 263
17 -16.6002x7i_A mol:protein length:308 MEVALONATE KINASE  ali model follow..  15  2....AMTRKGYGESTGKIILI---G---EHAVTFGEPAIAVPFNAGKIKVLIEALESGNYSSIKSDVYDGMLYDAPDHLKSLVNRFVELNNITE----------------PLAVTIQTNLPPSRGLGSSAAVAVAFVRASYDFLGKSLTKEELIEKANWGKPSGI-IVSGKPVWFQKGH--------AETLKTLSLDGYMVVIDTGVKGSTRQAVHDVHKEDPQYMSHVKHIGKLVLRASDVIEHHKFEALADIFNECHADLKALTVSHDK------------IEQLMKIGKENGAIAGKLT-GRGGSMLLLAKDLPTAKNIVKAVEKA.................................................................................... 296
18 -16.6004hac_A mol:protein length:321 Mevalonate kinase  ali model follow..  15  8.LVPRGSHMVSCSAPGKIYLF---G---EHAVVYGETAIACAVE---LRTRVRAELNDSITIQSQIGRTGLDFEKHPYVSAVIEKMRKSIPIN-----------------GVFLTVDSDIPVGSGLGSSAAVTIASIGALNELFGFGLSLQEIAKLGHEISPDTYVSTFGGVVTIPERRKLKTPDCGIVIGDTG--------VFSSTKELVANVRQLRESYPDLIEPLMTSIGKISRIGEQLVLSGDYASIGRLMNVNQGLLDALGVNILE------------LSQLIYSARAAGAFGAKITGAGGGGCMVALTAPEKCNQVAEAVAGA.................................................................................... 298
19 -16.4006cyz_A mol:protein length:308 Homoserine kinase  ali model follow..  16  3MSEVPAGLATTVLVPASSANL---G--------PGFDSLGIALS---LYDEIEVNTTESGLKVAVEGQGAGELDGSHLVVRAIERGLAAGGAAAP---------------GLIVQCHNKIPHSRGLGSSAAAAVAGLGVANGLLAAVLSDDVLVQLASEFEGNAAASVLGGAVVSWSETSGATPIYAATRLDVHPDIK-IVAAIPEEQSSTAHTRVLLPQAVTHVDARFNISR---VALLTVALTARPDLLMTATED---RLH-------------QPQRASAMPASADVLAYLRSQGVAAVLSAGPAVLALTTVDLPDSAVKYAEDQGF................................................................................... 294
20 -16.1002hfs_A mol:protein length:332 Mevalonate kinase, putative  ali model follow..  13  13........TGKNIGYGKVILF---GEHAEAIVAGISEYTECRLEINPGVPGLQVDDQRPAIPGYIAQKRDEQIKAHQLVLDHLKVDLSGDG--------------------LKMFIGGPLVPSSGIGASASDVVAFSRALSELYQLNLTDEEVNLSAFVGTPSGA-ATYGGLILYRRQNGKSVFKPIAFQQRLY-----LVVVGTGINASTAKVHKMKQQQPVQFKRLYDNYTHIVSQAREALQKGDLQRLGQLMNANHDLCRQIDVSCRE------------LESIVQTCRTYGALGAKLS-GRGGIAVALAASSDQRDAIVKGLKAKCPEA................................................................................ 316
21 -16.0001vis_A mol:protein length:324 Mevalonate kinase  ali model follow..  14  1.......MSLIIETPSKVILF---G---EHAVVYGYRAISMAID---LTSTIEIKETQEDEIILNLNDNKSLGLNLNEIKNINPNNFGDFKYCLCAIKNTLDYLNIEPKTGFKINISSKIPISCGLGSSASITIGTIKAVSGFYNKELKDDEIAKLGYMGKASISTITYKGILEIKNNKFRKIKGEFEEFLKNC---KFLIVYAEKRKKKTAELVNEVAKI----ENKDEIFKEIDKVIDEALKIKNKEDFGKLMTKNHELLKKLNIST--------PKLDRIVDIGNR-----FGFGAKLTGAGGGGCVIILVNEEKEKELLKELNKEDVRIFNCRMMNEGGS..................................................................... 318
22 -15.9005wat_A mol:protein length:315 Homoserine kinase  ali model follow..  19  1MAIENVGRKVTVTVPGSSANLG--GFDTLGLALSVYDTVEVEIIPSGLEVEVFGEGQGEVPLD-------GSHLVVKAIRAGLKAADAEVP-------------------GLRVVCHNNIPQSRGLGSSAAAAVAGVAAANGLADFPLTQEQIVQLSSAFEGNAAASVLGGAVVSWTNLSIDGKSQPQYAAVPLEVQDNIRATALVPN-STEAVRRVLPTEVTHIDARFNV--SRVAVMIVALQQRPDLLWEGTRDR-----------------LHQPYRAEVLPITSEWVNRRNRGYAAYLSGAGPTAMVLSTEPIPDKVLEDARESGI................................................................................... 291
23 -15.8001kkh_A mol:protein length:317 Mevalonate Kinase  ali model follow..  14  2.....RGSHMIIETPSKVILF---G---EHAVVYGYRAISMAID---LTSTIEIKETQEDEIILNLNDNKSLGLNLNEIKNINPNNFGDFKYCLCAIKNTLDYLNIEPKTGFKINISSKIPISCGLGSSASITIGTIKAVSGFYNKELKDDEIAKLGYMGKASIT-ITYKGILEIKNNKFRKIKGEFEEFLKNCKFLIVYAEKRKKKTAELNEVAKIENKDEIFKE----------KVIDEALKIKNKEDFGKLMTKNHELLKKLNIST--------PKLDRIVDIGNR-----FGFGAKLTGAGGGGCVIILVNEEKEKELLKELNKE.................................................................................... 306
24 -15.8004rpf_A mol:protein length:310 Homoserine kinase  ali model follow..  12  2........MVKIYAPASIGNV------------VGFDVLGAAVSPIDGTLLGDCVSVTAAERFSLHNEGRFVSKLPDDPKQNI-----------VYQCWERFCQEMGKEIPVAMVLEKNMPIGSGLGSSACSVVAGLMAMNEFCGQPLDKVTLLGMMGRVSGSIAPCYLGGMQLILEQEGYISQDVPGFS---------WVMAYPGIKVSTAEARAILPAQYRRQDCITHG--RNLAGFIHACHTQQPDLAAKMMKD----------------VIAEPYRTQLLPGFAAARQQDIGALACGISGSGPTLFAVCNDQATAQRMAGWLQNHYLQ................................................................................. 290
25 -15.7001k47_A mol:protein length:337 phosphomevalonate kinase  ali model follow..  9  2.......MMIAVKTCGKLYWA---G--EYAILEPGQLALIKDIP---IYMRAEIAFSDSYRIYSDMFDFAVDLRPNPDYSLIQETIALMGDF---------LAVRGQNLRPFSLAIYGKMEREGGLGSSGSVVVLVVKALLALYNLSVDQNLLFKLTSADNGSMACIAAEDLVLYQSFDRQK-ERDWGFSISQVKPTLECDFLVGWTKEVAVSSHMVQQIKQNINQNFLTSSKETVVSLVEALEQGKSEKIIEQVEVASKLLEGLSTDIYTP----------LLRQLKEASQDLQAVAKSSGAGGGDCGIALSFDAQSTKTLKNRWADL.................................................................................... 321
26 -15.7004dxl_A mol:protein length:318 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase  ali model follow..  14  9VSDWVPTGAVTVRAPGKVNLLAVGDLRDDGYH-----ELTTVFHAVSLADDVTVRDADVLSIDVVGQGEGTVPTDERNLAQAAELFADHVGR----------------APDVSIFINKDIPVAGGMAGGSADAAAVLVAMNELWHAGVPRRDLHHLAAQLGSDVPFALHGGTAL---------GTGRGEQLATVLARNVFHWVFAFADGG-------LATPQVFKE--DPPRLAEADELLGALAAGDARRLAPLLGNE---LQAAAVSLNPE-----------LRRTLRAGESAGALAGIVS-GSGPTCAFLCTSADDAVQVSAELAGAGVCRTVRVASGPVHGAQVIQGRS............................................................. 316
27 -15.3003k85_A mol:protein length:357 D-glycero-D-manno-heptose 1-phosphate kinase  ali model follow..  10  1......MSLVRSKAPLRLGLA---GGSDLILNATINLYAYCTIEETNSGRIEINAYDAQCCKSYLSMSQLEIDGEASLIKGVYNRIIRDYRLEPK---------------SFKITTYNDAPAGSGLGTSSTMVVCILKAFIEWLSLPLGDYETSRLAYEGKQDQYAAAFGGFNYMEFLQNDLVIKRWIVDELESSMVLYFTGRSRSSAAIINEQKKNTSEGNQTAIEAMHKIKQSAIDTKLALLKGDVGEFARILGEGWENKKKM-----------GAITNPMIQEAFDVATGAGAMAGKVSGAGGGGFIMFVVEPTRKEEVVRALNNLNGFVMPFQFIDDGAHGWKIYSTDKVQKE........................................................ 350
28 -15.2004n3o_A mol:protein length:342 Putative D-glycero-D-manno-heptose 7-phosphate kinase  ali model follow..  11  1...SNAMKTIRTQTPLRLGLA---GGTDINLNATISLYIHCTLIKREDGKIIFDSPDTNSYCEYESKEFLGNDGKLDIFKSIYNRIVKDFTK---------------KPLSFSLHTYSDVPSGSGLGGSSTLVVGVIKAFAEWLNLPLGEYEIAKLAYEGAQDQYAATFGGFNFMEFYNNKRVIVN-NWIASELEARTVLYFTNITREAKDIEEHKKGKLGDEKSLEAMHAIKQDAIKMKEALFRADFGTLAQILGKSWRSKKIIS----------EIVSNDELERIYKLAIDNGAYSGKTSGAGAGGFMFFFVDPTKKYNLIKALRKEQGYVQDFSFTKEGVKSWRI................................................................. 342
29 -15.1003pyd_A mol:protein length:306 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase  ali model follow..  12  3......TGSVTVRVPGKVNLLAVGDRREDGYH-----ELTTVFHAVSLVDEVTVRNADVLSLELVGEGADQLPTDERNLAQAAELMAEHVGR----------------APDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTAL---------GTGRGEELATVLSRNTFHWVLAFADSG-------LLTSAVYNE--DPPRLGEPGPVLAALAAGDPDQLAPLLGNE---MQAAAVSLDPA-----------LARALRAGVEAGALAGIVS-GSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVVSAPTEV........................................................... 306
30 -14.8002oi2_A mol:protein length:292 Mevalonate kinase  ali model follow..  13  1MTKK----VGVGQAHSKIILI---G---EHAVVYGYPAISLPLLEVEVTCKVVPA------------ESPWRLYEEDTLSMAVYASLEYLNITEA---------------CIRCEIDSAIPEKRGMGSSAAISIAAIRAVFDYYQADLPHDVLEILVNRMNPSGL-CLSDQPIRFIKNV--------GFTELEMDLSAYLVIADTGVYGHTREAIQVVQNKGKDALPFLHALGELTQQAEIAISQKDAEGLGQILSQAHLHLKEIGVSSLE------------ADSLVETALSHGALGAKMS-GLGGCIIALVTNLTHAQELAERLEEK.................................................................................... 282
31 -14.8004usk_A mol:protein length:346 PUTATIVE SUGAR KINASE  ali model follow..  12  1MNPT----IIRARAPLRLGLA---GGTDVAPYADTFGGLNATIDRYAYAVI------KTLTIPAVRFVSTDQQVEKHQLISEPLELNGTLNLHKAVYNHMIRNYNHGKPIALELSTFCDAPAGSGLGSSSTLVVVMIKAFVELLNLPLDDYAIAQLAYRGRQDQYSATFGGFNFMEFYAAARTIKNWVLCELEASLVLFYTGVSRESAKIIQDQSDNVVSHKTAAIEAMHGIKREALVMKEALLKGDFKAFVASMRLG----WDNKKNSARTV------SNAHIDEIYDAAIRAGAQAGKVSGAGGGGFMLFFVPTEKRMDLIRTLGEYDGQVSNCHFTKNGT...................................................................... 339
32 -11.8001wuu_A mol:protein length:399 Galactokinase  ali model follow..  12  30........ELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVL-------VGSPRKDGLVSLLTTSEGADEPQRLQFPLPTAQRSLEPGTPRWANYVKGVIQYYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQVCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRRRQ-GEIRRTAQAAAALRRGDYRAFGRLMVES----HRSLRDDY-------EVSCPELDQLVEAALAVPGVYGSRMTGGG-GCTVTLLEASAAPHAMRHIQEHYGGTATFYLSQAADGAKVL................................................................. 391
33 -11.6002r3v_A mol:protein length:396 Mevalonate kinase  ali model follow..  14  1MLSE----VLLVSAPGKVILH---G---EHAVVHGKVALAVSLN---LRTFLRLQPHSNGK-QSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRGNPSGAVSTWGGALRYHQGKISKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVG--------HASLDQLCQVTRAR-----GLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL................................................................................... 360
34 -11.4001kvk_A mol:protein length:395 mevalonate kinase  ali model follow..  14  1MLSE----VLLVSAPGKVILH-VHGKVALAVALNLRTFLVVSLNLPNVGIKQVWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVGNEGYLAICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEEEDLKSINKWAYEGNPSGV-STWGGALRYQQGKMSSLKRLPALQILLTNTKVPRSTKALVAGVRSRLIKFPEIMAPLLTSAISLECERVLGEMAAAPVPEQYLVLEELMDMNQHHLNALGVG--------HASLDQLCQVTAA-----HGLHSKLTGAGGGGCGITLLKPGLERAKVEAAKQAL................................................................................... 360
35 -11.2002v2q_A mol:protein length:271 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE  ali model follow..  12  1...GSHMIKVLSPAKINLGL-WVLGRLPSGYH-----EILTLYQEIPFYDEIYIR-----EGVLRVETNIGIPQEENLVYKGLREFERITGI----------------EINYSIFIQKNIPPGAGLGGGSSNLAVVLKKVNELLGSPLSEEELRELVGSISADAPFFLLGKSAI---------GRGKGEVLEPVETEISGKITLVIPQVS-------SSTGRVYSS-EHFVTPEYAEEKIQRIISGEVEEIENVLGDIARELY--------------PEINEVYRFVEY------LGFKPFVSGSGSTVYFFGGASEELKKAAKMR....................................................................................... 262
36 -11.2001oj4_A mol:protein length:283 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE  ali model follow..  10  1.......MRTQWPSPAKLNLLYITGQRADGYH-----TLQTLFQFLDYGDTISIELRDDGD--RLLTPVEGVEHEDNLIVRAARLLMKTAADSGRLP----------TGSGANISIDKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSMDELAEMGLT--GADVPVFVRGHAAFAEGVGEILTPVDPPEK--------YLVAHPGVSIPTPVIFKDPELP-------RNTPKRSIETLLKCEFSNDCEVI----------------------------ARKRFREVDAVLSWLLEYAPSRLTGTGACVFAEFDTESEARQVLEQAPEWL................................................................................... 265
37 -11.1002cz9_A mol:protein length:350 Probable galactokinase  ali model follow..  11  2.........IKVKSPGRVNLIGEHTDYTYGYVMPMAINLYTKIEAEKHGEVILYSEHFGEERKFSLNDLRKENSWIDYVKGIFWVLKESDYEVG----------------GIKGRVSGNLPLGAGLSSSASFEVGILETLDKLYNLKLDSLSKVLLAKKAEGREGNVIFKDVSILVFYTGVRRELASSEYAERKHIAEESLKILGKGSSKEVREGELSKLPPLHRKFFGYIVRERVLEVRDALKEGNVEEVGKILTTAHWDLAKNYEVSCKELDFFVERA------------LKLGAYGARLTGAG-GSAIALVDKEDAETIGEEILREYLKR................................................................................ 332
38 -10.9001s4e_A mol:protein length:352 Galactokinase  ali model follow..  11  3........KITVKSPGRVNLIGEHTDYTYGYVMPMAIDLYTIITAEKYDKVQLYSEHFNEEKTFTLDNLTKEGSWIDYVKGVLWVLIQEGYKIG----------------GLKGKITGDLPLGAGLSSSASFEVGILEVLNQLYNLNIDPLKKALLAKKAENEFV-GVPCGILDQFAVVFGKKDNVIFLDTQTLQYEYIPFPKDVSVLVFYTGVKRELASSEYAERKRI-RENARVLEVRDALKEGDIEKVGKILTTAHWDLAENYRVSCEELDFFVKKA------------MELGAYGARLTGAG-GSAIALVDKDKAKTIGDAILREYLAK................................................................................ 334
39 -10.7001pie_A mol:protein length:419 Galactokinase  ali model follow..  10  45...........FFSPGRINLIGEHTDYNGGYVFPASITIGTTG-LARLREDKKVKLYSENFPKLGVIEFDLDEVEKKDGELWSNYVKGMIVMLK--------GAGYEIDKGFELLIKGEIPTASGLSSSASLELLVGVVLDDLFNLNVPRLELVQLGQKTENDYIGVNSGILDQFAIGFGEVKKAIELDCNTLKYEMVPVELRDYDIVIMNTNKPRALTESK-YNERFAEYENNRTKIAQKAFVAGNLTKFGELLNASHASLKDDYEVTGLE-----------LDTLAETAQKQAGVLGARMTGAG-GCAIALVAHDNVSAFRKAVGQVY................................................................................... 388
40 -9.9801uek_A mol:protein length:275 4-(cytidine 5`-diphospho)-2C-methyl-D-erythritol kinase  ali model follow..  13  1.......MERLAPAKVNLGL-SVRFRREDGYH-----ELHTLFAPFSLADRLVVEPVSSG------LHFQGPYGRENLAYRAASLYLEAAGQ----------------PGGVRILLEKRIPEGAGLGGGSSDAAQVLLALQALYPAEVDLFALA--RTLGAD--------PFFLLGRGAEARGVGERLKPLALPPVP--AVVFFPGLRVPTPLVYRAVRPE-------DFGPDLPVEAILEALARGEEPPYWN-------SLEGPAFRLFPELKEVRGRMRAL------------GLRGVLMSGSGSAFFGLAEGPDHARRAAEALRAWGR.................................................................................. 259
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Harder T, Kolodny R, Sitbon E, Li Z, Godzik A. Using an alignment of fragment strings for comparing protein structures. Bioinformatics. 2007 Jan 15;23(2):e219-24.