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Query: [R] KOG3518 Putative guanine nucleotide exchange factor, from COG1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MCAAQAHQHCSTSVAGDRLLGSSTELAPSLLGIYDTLTNSFAAGGVAAAPTATSHESKASSSGDSTPKRSNSNCSSSSSTGSSTGSCSSVPTSDDQSASYTLASSSTHLGHQEPPAPLVVAGLRDEPDGAQLSRLVQRRSQESQIHGSSSSIASSGSSRRGSNIRILSPNVHRIITHSDIQPVEAVSAEALKQHQQQSQRSPTQGRYIKTGHSGTPPAAGSAPKLKLSHIPLSKITGKLSTQSGSELVSTFDSSNEYLNSVAFAAFEKSKPQDEDRTPTNKSVPGTPFHFDGHPFQGRKLTLPRYDSQQSIKLIEMEQLAATSAQLLHAKPATPGTPATPTPSATKAKEFVCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEGECFPLGLast
1 -61.7002nz8_B mol:protein length:313 triple functional domain protein  ali model follow..  25  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GAMEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGEEIPPNKELIIFGNMQEIYEFHNNFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILE-----HAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGEIKDGLEVMLSVPKRANDAMHLSMLEG------------FDENIESQGELILQESFQVRKGRERHLFLFEMSLVFSKEVKDSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTNKIVLKASSIENKQDWIKHIREVIQER......................... 312
2 -61.5001kz7_A mol:protein length:353 GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS  ali model follow..  23  2......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GEEEESLAILRRHVMNELLDTERAYVEELLCVLEGYAAEMDNPLMAHQNKKNILFGNMEEIYHFHNRFLRELESCIDCPELVGRCFLERMEEFQIYEKYCQNKPRSESLWRQCSDCP----FFQECQKKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWKGHTKVKELARFKPMQRHLFLHEKAVLFCKKREEPSYSYKQSLNMTAVGITENVKGDTKKFEIWY-NAREEVYIIQAPTPEIKAAWVNAIRKVLTSQLQA-CREASQHRALEQSHSLE.... 347
3 -60.5002rgn_B mol:protein length:354 Rho guanine nucleotide exchange factor 25  ali model follow..  23  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQPESLRGRDRIVFGNIQQIYEWHRDFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGD-----SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYDTADLEQAVEVMCFVPKRCNDMMTLGRLRG------------FEGKLTAQGKLLGQDTFWVSRGRERRVFLFEQIIIFSEALGGPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGQRYVLQAADPAISQAWIKHVAQILESQRDF-LNALQSPIEYQRRESQTNSLG 344
4 -55.4001foe_A mol:protein length:377 T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1  ali model follow..  22  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AMGRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPRQQHSSTLESYLIKPIQRVLKYPLLLRELFALTEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDIAEQTGEKKEVADLSMGDLLLHTSVIWKKEPELAAFVFKTAVVLVYKDEWDPFRFRHMIPTEALQVRALPSADAEANAVCEEGRPERVFHLCCSSPESRKDFLKSVHSILRDKHRRQLLKTE................ 377
5 -52.6002kr9_A mol:protein length:190 Kalirin  ali model follow..  25  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GPLGSPEFPGRKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPNKEHIIFGNIQEIYDFHNNFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAG-----TFFDEIQQRHGLANSISSYLIKPVQRVTKYQLLLKELLTCCEEGELKDGLEVMLSVPKKANDAMH.................................................................................................................................................... 189
6 -51.3002dx1_A mol:protein length:482 Rho guanine nucleotide exchange factor 4  ali model follow..  23  124................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKIDISLDGFLLTPVQKICKYPLQLAELLKYTDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLVRSSELIYSGELTRAKSQQRMFFLFDHQLIYCKKDRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQL....................... 481
7 -51.2003ky9_A mol:protein length:587 Proto-oncogene vav  ali model follow..  19  154....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQR---LKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGNLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREVQMKLEECSQRNNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENL-DQSLAHYGRPKIDGELKIRSKMDRYAFLLDKALLICKRRG-DSYDLKDFVNLHSFQVRDDSSGDRDMFLL-IEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTS... 531
8 -50.8004mt7_A mol:protein length:485 Rho guanine nucleotide exchange factor 9  ali model follow..  22  74....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGDDILDSSELIYTGEMAWGRNQQRVFFLFDHQMVLCKKDRRDILYYKGRIDMDKYEVIDIEDGRDDDFNVLHNKETEEVHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRK. 449
9 -50.8002pz1_A mol:protein length:466 Rho guanine nucleotide exchange factor 4  ali model follow..  22  87................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKIDISLDGFLLTPVQKICKYPLQLAELLKYTDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVSSELIYSGELTRAKSQQRMFFLFDHQLIYCKKDRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLTELQRKQAMLNASK......... 466
10 -50.5004mt6_A mol:protein length:456 Rho guanine nucleotide exchange factor 9  ali model follow..  21  74...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NQEDGVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQIDIAIDGFLLTPVQKICKYPLQLAELLKYTDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGDDILDSSELIYTGEMAWGRNQQRVFFLFDHQMVLCKKDRRDILYYKGRIDMDKYEVIDIEDGRDDDFNVLHNKETEEVHLFFAKKLEEKIRWLRAFREERKM-----QEDEKIGFEISENQKRQAAMT 455
11 -50.4004yon_A mol:protein length:405 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein  ali model follow..  23  2...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVALTEENVKVLFSNIEDILEVHKDFLAALEYCLHSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKIPLEGYLLSPIQRICKYPLLLKELAKRTDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDCTQLLLQGTLLKISAQERAFFLFDNLLVYCKRKNGSLYIFRGRINTEVMEVENVEDGTTNGWKI-HNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMER................ 404
12 -50.2002vrw_B mol:protein length:406 PROTO-ONCOGENE VAV  ali model follow..  20  2........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DEIYEDLMRLESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQR---LKPQDMETIFVNIEELFSVHTHFLKELKDALAGPGTLYQVFIKYKERFLVYGRYCSQVESASKHLDQVATAREDMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENL-DQSLANYGRPKIDGELKIRSKTDRYAFLLDKALLICKRRG-DSYDLKASVNLHSFQVRDDSSGERDNKKLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTS... 359
13 -49.6005fi0_A mol:protein length:374 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein  ali model follow..  25  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EFAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVALTEENVKVLFSNIEDILEVHKDFLAALEYCLHSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKIPLEGYLLSPIQRICKYPLLLKELAKRTDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDCTQLLLQGTLLKISAQERAFFLFDNLLVYCKRKNGSLYIFRGRINTEVMEVENVEDGTTNGWKI-HNTAKNKWFVCMAKTAEEKQKWLDAIIREREQSLKLGMERDAYVM............. 374
14 -49.3002dfk_A mol:protein length:402 collybistin II  ali model follow..  22  5...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NQEDGVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQIDIAIDGFLLTPVQKICKYPLQLAELLKYTDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGDDILDSSELIYTGEMAWGRNQQRVFFLFDHQMVLCKKDRRDILYYKGRIDMDKYEVIDIEDGRDDDFNVLHNKETEEVHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQ........ 382
15 -43.7004h6y_A mol:protein length:501 FERM, RhoGEF and pleckstrin domain-containing protein 1  ali model follow..  18  1..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GPHMDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLADYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSRRLENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHDFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDN--VVPGREFIRLGSLSKLSGKQRMFFLFNDVLLYTSRGASNQFKVHGQLPLYGMTIEESEDEWGVPLTL---RGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSSSPAPEF............... 334
16 -43.3004gzu_A mol:protein length:501 FERM, RhoGEF and pleckstrin domain-containing protein 2  ali model follow..  22  2..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PHMEDEAYFIAKEILATERTYLKDLEVITVWFRSVLIKEEAMPAALMALLFSNIDPVYEFHRGFLHEVEQLKGDHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKCKKLEAVYKEFELQKVCYLPLNTFLLKPVQRLVHYRLLLSRLCAHYDYADCHEALKAITEVTTELQQSLTRLENLQKLTELQRDLVGVEN--IAPGREFIREGCLHKLTKKQRMFFLFSDMLLYTSKSGASHFRIRGFLPLRGMLVEESENEWSVLFTI---YAAQKTIVVAASTRLEKEKWMQDLNAAIQAAKTIGDSPPVLL.............. 337
17 -43.1001by1_A mol:protein length:209 PROTEIN (PIX)  ali model follow..  23  2....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPQRVGGCFLNLMPQMKLYLTYCANHPSAVNVLTEHSE--ELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILT.......................................................................................................................................... 205
18 -42.3004xh9_A mol:protein length:361 Neuroepithelial cell-transforming gene 1 protein  ali model follow..  21  20.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKP-EQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNEQVYRQPIPVQELVLEDLQDGAKNIFRIRFHPSPAQSHTLQANDVFHKQQWFNCIRAAI............................ 354
19 -42.0003mpx_A mol:protein length:434 FYVE, RhoGEF and PH domain-containing protein 5  ali model follow..  17  2.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSGRENLYFQGGQSRALVIAQELLSSEKAYVEMLQHLNLDFHGAVMRRDTLAREELRQGLSELPAIHDLHQGILEELEERLSNQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCHSPRLAAAVREFEQSVQGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHIEHSVRGQGD--LQPGREFLKEGTLMKKNRRPRHLFLMNDVLLYTYPQKDGKYRLKNTLAVANMKVSRPVMEKPYALKI---ETSESCLMLSASSCAERDEWYGCLSRALPEDYK....................... 335
20 -41.7004gou_A mol:protein length:518 EhRGS-RhoGEF  ali model follow..  10  76................................................................................................................................................................................................................................................................................................................................................................................................................................................DRNSERQVNLSYQIQQSILKKLSEVTSNAPKDVFNEAKKATEYLLYTEQYTYFINKLNANTIGTGKKDVYSLYLNQFPKTNPQPLYKPTLNKIIEIEKKSWNEDEVKRNTESIKSLVESLIQDECNYVGVLTSLSE-FSEIMTKKQILGPDVLKELFDHIPVLIQHHQKFISSLQEAKADE-KVGEKLNSGLHFLVLYRYYLRHVPKNIAKLCSIGMTDEIEVEEFDKQQKMTKKMSVLQMLVYPYFRVRTYQAYVDDFIKITEVKELEVVHSQLAIFQELINTYSDINKIERISDALKLLFPFSFTSIMPLF-DINQLSMSLNSRKKLTLIILYRGVVVTDVPVIRKKSIDKSFYSFTLIGDIRDFGTEDSTETIYIDPEIKKRIWFGCESTEEFKSCVEALRTIL............................ 518
21 -39.8002z0q_A mol:protein length:352 Rho guanine nucleotide exchange factor 3  ali model follow..  19  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSGSSGCVNQVLTAKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP-EHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLES--RKLDLWNFLDIPRSRLVKYPLLLREILRHTDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNYQLYRQPIPVKDLTLEDLQDGEKNFFRVSFKNGSQQTHSLQANDTFNKQQWLNCIRQAKESGPS....................... 350
22 -36.7001ki1_B mol:protein length:352 intersectin long form  ali model follow..  17  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKM-KMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDAPDFKEFVKRLEMD--KGMPLSSFILKPMQRVTRYPLIIKNILENTDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQ----TNCLGPRKFLHSGKLYKAKNKELYGFLFNDFLLLTQITKNLQYMYKTPIFLNEVLVKLPTDPSGDEP-IFHISHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKR................. 352
23 -36.7003qbv_B mol:protein length:351 Intersectin-1  ali model follow..  16  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKM-KMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDAPDFKEFVKRLAMD--KGMPLSEFILKPMQRVTRYPLIIKNILENTDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQ--SVTNCLGPRKFLHSGKLYKAKSKELYGFLFNDFLLLTQITKPQYKMYKTPIFLNEVLVKLPTDPSGDEP-IFHISHIDRVYTLRAESINERTAWVQKIKAASELYIETEKK................... 351
24 -36.1003jzy_A mol:protein length:510 Intersectin 2  ali model follow..  19  2............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSGRENLYFQGDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKT-QMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDDTDFKEFLKKLASD--KGMPLSSFLLKPMQRITRYPLLIRSILENTDHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQ----TNCLGPRKLLHSGKLYKTKSKELHGFLFNDFLLLTYMVKQFAVMYKTPIFLNEVLVKLPTDPSSDEP-VFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKQREKAYQARSQKTSGIGR. 382
25 -34.7003eo2_A mol:protein length:231 Neuroepithelial cell-transforming gene 1 protein  ali model follow..  22  18.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKP-EQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLES--RKLDLWSFLDIPRSRLVKYPLLLKEILKHTDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYL...................................................................................................................................... 224
26 -33.7005n7e_B mol:protein length:219 Breakpoint cluster region protein  ali model follow..  18  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AMASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQ-QRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQNAQFAEISENLRARSNKKNSLETLLYKPVDRVTRSTLVLHDLLKHTDHPLLQDALRISQNFLSSINEEITPRRQSMTV............................................................................................................................................ 218
27 -33.2003odw_A mol:protein length:536 Rho guanine nucleotide exchange factor 1  ali model follow..  19  172.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQE-EEIGDVLLARSWFQKISSRFCSRQSFALEQLKAKQRDPRFCAFVQEAESR--RRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSD--KLVHEGPLTWRVTKDKHVLLLDDLLLLLQRQDEGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETA............................ 523
28 -32.6003jv3_A mol:protein length:283 Intersectin-1  ali model follow..  18  74.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLTESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSKMIGDILSAQLPHMQPYIRFCSCQLNGAALIQQKTDAPDFKEFVKRLAMD--KGMPLSSFILKPMQRVTRYPLIIKNILENTDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQA....................................................................................................................................... 283
29 -31.8003gf9_A mol:protein length:295 Intersectin 2  ali model follow..  21  84.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDDTDFKEFLKKLASD--KGMPLSSFLLKPMQRITRYPLLIRSILENTDHSSLKLALERAEELCSQVNEGVREKENSDRL............................................................................................................................................ 288
30 -29.9003t06_A mol:protein length:418 Rho guanine nucleotide exchange factor 11  ali model follow..  17  55.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREE-KEISDLMLAREELQQVAAQFCSYQSIALELIKTKQRESRFQLFMQEAESH--RRLQLRDLIISEMQRLTKYPLLLESIIKHTEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASN--KMIHEGPLTWRISKDKHVLLLEDLLVLLQKQDEKLLTFSPVLKLNAVLIRSVATDKRAFFIICTSKGPPQIYELVALTSSDKNTWMELLEEAVRN.......................... 409
31 -29.5004d0n_B mol:protein length:373 A-KINASE ANCHOR PROTEIN 13  ali model follow..  16  21.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKE-KRIGDVLVNQERLKKTYGKFCGQHNQSVNYFKDLYKDKRFQAFVKKKMSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDMFAKEDLKRK-KLVRDGSVFLKNAAGRQAVLLTDILVFLQEKDQKY-QKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTI............................ 367
32 -29.5003p6a_A mol:protein length:377 Rho guanine nucleotide exchange factor 1  ali model follow..  19  19.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESEEIGDVLLARSWFQKISSRFCSRQSFALEQLKAKQRDPRFCAFVQEAESR--RRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSD--KLVHEGPLTWRVTKDKHVLLLDDLLLLLQRQDEGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETA............................ 370
33 -29.4003kz1_A mol:protein length:383 Rho guanine nucleotide exchange factor 11  ali model follow..  17  18.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREE-KEISDLMLAREELQQVAAQFCSYQSIALELIKTKQRESRFQLFMQEAESH--RRLQLRDLIISEMQRLTKYPLLLESIIKHTEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASN--KMIHEGPLTWRISKDKHVLLLEDLLVLLQKQDEKLLTFSPVLKLNAVLIRSVATDKRAFFIICTSKGPPQIYELVALTSSDKNTWMELLEEAVRNATRHP..................... 377
34 -29.4001txd_A mol:protein length:385 Rho guanine nucleotide exchange factor 12  ali model follow..  18  16.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKRNEQIGEDLLTWEKLKHAAATFCSNQPFALEMIKSRQKDSRFQTFVQDAESNLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEREKVKKAADHCRQILNFVNQAVKEAENKQRLEDYQRRLDTSSLKLSEY--KMIHEGPLVWKVNRDKYTLLLEDILVLLQKQDDRLVTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSVD................... 377
35 -25.6004d0o_A mol:protein length:244 A-KINASE ANCHOR PROTEIN 13  ali model follow..  15  23.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKE-KRIGDVLVNQERLKKTYGKFCGQHNQSVNYFKDLYADKRFQAFVKKKMSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT....................................................................................................................................... 243
36 -21.9001fho_A mol:protein length:119 UNC-89  ali model follow..  14  2...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GDTGKLGRIIRHDAFQVWPPKLRYVFLFRNKIMFTEQDASPSYTHYSSIRLDKYNIRQHTTDED-TIVLQPQEPGLPSFRIKPTSEYVRKAWLRDIAEEQEKY......................... 114
37 -18.9001pms_A mol:protein length:136 SOS 1  ali model follow..  16  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SKQLAIKKMNEIQKNIDGWEGKDIQCCNEFIMEGTLTVGAKHERHIFLFDGLMICCKSNSSAEYRLKEKFFMRKVQINDKDDTSEYKHAFEIILKDGNSVIFSAKSAEEKNNWMAALISLQYRS......................... 136
38 -18.2001v61_A mol:protein length:132 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6  ali model follow..  16  2.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSGSSGQILSEPIQAWEGDDIKTLGNVIFMSQVVMQHKEERYFLLFSSVLIMLSASRMSGFMYQGKIPIAGMVVNRLDEIEGSDCMFEITGSTVERIVVHCNNNQDFQEWMEQLNRLTKSGPS....................... 130
39 -18.1005d27_A mol:protein length:167 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein  ali model follow..  17  2...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EFEKLEALEQLQSHIEGWEGSNLTDICQLLLQGTLLKISAQERAFFLFDNLLVYCKRKNGSLYIFRGRINTEVMEVENVEDGTADYWKI-HNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVM........... 167
40 -15.7003ksy_A mol:protein length:1049 Son of sevenless homolog 1  ali model follow..  18  191......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEVGSCFLAEELAFDPYESYARDRPGFHDRFLSQLSKPGAALYLQSIGEGFKEQYVLPRLLLAPVYHCLHYFELLKQLEEKSDKECLKQAITALLNVQSGMEKMKGKQLAIKKMNEIQKNIDGWEGKDIQCCNEFIMEGTLRVGAKHERHIFLFDGLMICCKSNSNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISL............................. 544
41 -14.2005oc7_D mol:protein length:133 Breakpoint cluster region protein,pleckstrin-homology domain of Bcr-Abl  ali model follow..  17  3.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MGEHRQLLKDSFMVEGARKLRHVFLFTDLLLCTKLKKTQQYDCKWYIPLTDLSFQM-VDEPSMAFRVH--SRNGKSYTFLISSDYERAEWRENIREQQKKFRSFSLTSVELQMLTNS......... 125
42 -13.6002lg1_A mol:protein length:185 A-kinase anchor protein 13  ali model follow..  14  6....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKKRKKLVRDGSVFAGRLKEVQAVLLTDILVFLQEKDQKYIFKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPS............... 184
43 -13.1005hzi_A mol:protein length:502 Intersectin-1,NPH1-1,Intersectin-1  ali model follow..  18  3..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVN-EEILGRNMRFLQGPETDRATVRKIRDAIDNQTEVTVQLINYTKS---NLFHLQPMRDQKGDVQYFIGVQLDGTEHMPLSSFILKPMQRVTRYPLIIKNILEHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQ---VTNCLGPRKFLHSGKLYAKSNKELYGFLFNDFLLLTQITNLQYKMYKTPIFLNEVLVKLPTDPDEPIFHI---SHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKLE................ 496
44 -12.8006bcb_A mol:protein length:146 Rho guanine nucleotide exchange factor 18  ali model follow..  15  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AIHYEKDQR----LKEIAAKTDQKSSGKLKNGLT----------------------------FRKEDMLQQRQLHLEGALCWKSTSGRLAVLLTDVLLLLQEKDQKYVFKPPVISLQKLIVREVANEEKAMFLISASMQGPEMYEMYTSSKEDRNIWMAHIRRAV............................ 142
45 -12.5003qwm_A mol:protein length:140 IQ motif and SEC7 domain-containing protein 1  ali model follow..  17  6.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LSLPHRRLVCYCRLFE------------------------VPDPNKPQK----------------------------------LGLHQREIFLFNDLLVVTKKKNSVTYSFRQSFSLYGMQVLLFENQYPNGIRLTSSADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQK......... 140
46 -12.2001zc4_B mol:protein length:120 exocyst complex protein Exo84  ali model follow..  15  5..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GQYLVYNGDLVEYEADHMAQLQRVHGFLMNDCLLVATWQRRGMYRYNALYPLDRLAVVNVKDNPPMKFKL---LMFPESRIFQAENAKIKREWLEVLEETKRALSDKRRREQEE............... 119
47 -11.5006bca_A mol:protein length:151 A-kinase anchor protein 13  ali model follow..  15  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GILDASYEKKVR----LNEIYTKTDSKSIMRMKSGQM----------------------------FAKEDLKRK-KLVRDGSVFLKNAAGRQAVLLTDILVFLQEKDQKYIFKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTI............................ 144
48 -10.8006bc0_A mol:protein length:150 Rho guanine nucleotide exchange factor 28  ali model follow..  13  4............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DEKNQKWLEILNKIENKTYTKLKNGHVFRKQAL--------MSEERTLLYDGLVYTGRFKDILALLLTDVLLFLQEKDQKYIFKPSVISLQKLIAREVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEK..................... 150
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 6   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Sequence clustering strategies improve remote homology recognitions while reducing search times. Protein Eng. 2002 Aug;15(8):643-9.