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Query: [S] KOG4463 Uncharacterized conserved protein, from COG1018

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSSANIVPSNMGITKFLLLTISTSSVVAGVFALKPFFHINFGLHLLSHYQYWRILLWQFIYWNSTEVFQALFIIYQARDVERLLGSHRFASFCVYMFILGMFVTPIFSFLYSLLFKNLDYIQPGPTFLIFAILYQYYYIVPSTVFVRLFNIKFTDKFQMVIPMIGLAFSHFPSTFINAFLGWTMGMFYHLSLLPGTSWRLPIRFVKPALSPTHVFIRPPYSDMQNASTFNPETLFALPTGLDAERTENENQVENPVSNADANDSPTRQNARATAIASSSNTAASFRNRQQISHPPLGRTSSSSVLPTGPASQLYDMLSGRSERPELGNIREEDINTVQTIMQTSRAQAIQALSQTNDVQRAVELLLEQTADYLast
1 -37.8004qnz_A mol:protein length:200 Rhomboid protease GlpG  ali model follow..  10  6........RAGPVTWVMMIACVVVFIAMQILGDQEVMLWAWPFDPTLKFEFWRYFTHALMHISLMHILFNLLWWWYLGAVEKRLGSGKLIVITLISALLSGYVQQKFS----------GPWFGGLSGVVYALMYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAM........................................................................................................................................................................................ 178
2 -36.6004njn_A mol:protein length:211 Rhomboid protease GlpG  ali model follow..  10  21........RAGPVTWVMMIACVVVFIAMQILGDQEVMLWAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGAVEKRLGSGKLIVITLISALLSGYVQQKFS----------GPWFGGLSGVVYALMYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAM........................................................................................................................................................................................ 193
3 -36.4002nr9_A mol:protein length:196 Protein glpG homolog  ali model follow..  12  7........QQGKITLILTALCVLIYIAQQLGFEDDIMYLHYPAYEEQDSEVWRYISHTLVHLSNLHILFNLSWFFIFGMIERTFGSVKLLMLYVVASAITGYVQNYVS----------GPAFFGLSGVVYAVLYVFIRDKLNHHLFDLPEGFFTMLLVGIALGFISPLFGVEMGNAAHISGLIVGLIW........................................................................................................................................................................................ 179
4 -19.2001vg5_A mol:protein length:73 rhomboid family protein  ali model follow..  18  1..............................................................................................................................................................................................................................................................................................................GSSGSSGSRQAPIANAAVLPQSQGRVAASEEQIQKLVAMGFDRTQVEVALAADDDLTVAVEILMSQSGP. 70
5 -18.9001veg_A mol:protein length:83 NEDD8 ultimate buster-1  ali model follow..  13  1..............................................................................................................................................................................................................................................................................................................GSSGSSGNPHMWWLQDADPENNSRQASPSQESINQLVYMGFDTVVAEAALRFGGNVQLAAQTLAHHGGS. 70
6 -18.3002qsf_X mol:protein length:171 UV excision repair protein RAD23  ali model follow..  9  10.........................................................................................................................................................................................................................LGTTGGATDAAQGGPPGSIGLTVEDLLSLRQVVSGNPEALAPLLENISARYPQLREHIMANPEEAVGDNMQDVMEGADDMVEGEDIEVTGEAAAAGLGQGEGEGSFQVDYTPEDDQAISRLCELGFERDLVIQVYFADKNEEAAANILFSDHAD. 171
7 -17.0002cwb_A mol:protein length:108 chimera of Immunoglobulin G binding protein G and Ubiquitin-like protein SB132  ali model follow..  13  2...............................................................................................................................................................................................................................................................................QYKLALNGKTLKGETTTEAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTEGSQWQPQLQQLRD-MGIDDELSLRALQTGGDIQAALELIFAGGA.. 101
8 -16.6002dai_A mol:protein length:83 Ubiquitin associated domain containing 1  ali model follow..  17  1..............................................................................................................................................................................................................................................................................................................GSSGSSGDAVELFKKANAMLDEDEDERVDEAALRQLTEMGFPENRATKALLNHMSVPQAMEWLIEHAED. 70
9 -16.4001wiv_A mol:protein length:73 ubiquitin-specific protease 14  ali model follow..  8  1..............................................................................................................................................................................................................................................................................................................GSSGSSGLLSHMDDPDIDAPISHQTSDIDQSSVDTLLSFGFAEDVARKALKASGDIEKATDWVFNNSGP. 70
10 -16.3001wgn_A mol:protein length:63 ubiquitin associated protein  ali model follow..  12  3..........................................................................................................................................................................................................................................................................................................................SGSSGAYSELQMLSPSERQCVETVVNMGYSYECVLRAMKKKENIEQILDYLFAHSGP. 60
11 -15.6002lbc_A mol:protein length:126 Ubiquitin carboxyl-terminal hydrolase 13  ali model follow..  17  3............................................................................................................................................................................................................................................................DESSVMQLAEMGFPLEACRKAVYFTGNMGAEVAFN------VHMEEPDFAEPLTMPGYGGAASAGASVFGASGLDNQPPEEIVAIITSMGFQRNQAIQALRANNNLERALDWIFSHPEF. 119
12 -15.5001vej_A mol:protein length:74 RIKEN cDNA 4931431F19  ali model follow..  15  1..............................................................................................................................................................................................................................................................................................................GSSGSSGARACSQSSQTALPTSLFTEGRYQQELEELKALGFNRDANLQALATDGDIHAAIEMLLGASGP. 71
13 -15.5002dak_A mol:protein length:63 Ubiquitin carboxyl-terminal hydrolase 5  ali model follow..  33  2...................................................................................................................................................................................................................................................................................................................................SSGSSGPPEDCVTTIVSMGFSRDQALKALRATNSLERAVDWIFSHIDD. 50
14 -15.4001wji_A mol:protein length:63 Tudor domain containing protein 3  ali model follow..  22  2...................................................................................................................................................................................................................................................................................................................................SSGSSGVDEKALKHITEMGFSKEASRQALDNGNNLEAALNVLLTSNKQ. 50
15 -15.0002ekk_A mol:protein length:47 UBA domain from E3 ubiquitin-protein ligase HUWE1  ali model follow..  21  1..................................................................................................................................................................................................................................................................................................................................GSSGSSGVNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTH.... 46
16 -14.9002oo9_A mol:protein length:46 E3 ubiquitin-protein ligase CBL  ali model follow..  18  1.......................................................................................................................................................................................................................................................................................................................................GSQLSSEIENLMSQGYSYQDIQKALVAQNNIEMAKNILREFAAA. 45
17 -14.9002dag_A mol:protein length:74 Ubiquitin carboxyl-terminal hydrolase 5  ali model follow..  10  2...................................................................................................................................................................................................................................................................................................................................SSGSSGLDESVIIQLVEMGFPMDACRKAVYYNSGAEAAMNWVMSHMDD. 51
18 -14.8001vek_A mol:protein length:84 ubiquitin-specific protease 14, putative  ali model follow..  15  1..............................................................................................................................................................................................................................................................................................................GSSGSSGGEELLPDGVPEEVMESAQPVANEEIVAQLVSMGFSQLHCQKAAINNAGVEEAMNWLLSHMDD. 71
19 -14.7001wj7_A mol:protein length:104 Hypothetical protein (RSGI RUH-015)  ali model follow..  17  1...................................................................................................................................................................................................................................................................................................GSSGSSGNQNQTQHKQRPQATAEQIRLAQMISDHNDADFEEKVKQLIDITGKNQDECVIALHDNGDVNRAINVLLEGNPD. 81
20 -14.7002juj_A mol:protein length:56 E3 ubiquitin-protein ligase CBL  ali model follow..  16  1...................................................................................................................................................................................................................................................................................................................................ATASPQLSSEIENLMS-QGYSYQDIQKALVAQNNIEMAKNILREFVSI. 48
21 -14.6002cpw_A mol:protein length:64 Cbl-interacting protein Sts-1 variant  ali model follow..  28  3..........................................................................................................................................................................................................................................................................................................................SGSSGRNRQQRPGTIKHGSALDVLLSMGFPRARAQKALASGRSVQTACDWLFSHSGP. 61
22 -13.8002g3q_A mol:protein length:43 Protein YBL047C  ali model follow..  19  1.......................................................................................................................................................................................................................................................................................................................................TTPKSLAVEELSGMGFTEEEAHNALEKNWDLEAATNFLLDSA... 43
23 -13.7002mr9_A mol:protein length:44 DNA damage-inducible protein 1  ali model follow..  18  1.....................................................................................................................................................................................................................................................................................................................................GSATFPEQTIKQLMDLGFPRDAVVKALKQNGNAEFAASLLFQS.... 44
24 -13.5004ae4_A mol:protein length:118 UBIQUITIN-ASSOCIATED PROTEIN 1  ali model follow..  14  47.............................................................................................................................................................................................................................................................................................................GQLCEKGFDPLLVEEALEMHQCSEEKMMEFLQLMSKFKEMGFELKDIKEVLLLNNDQDNALEDLMARAGA. 117
25 -13.4001whc_A mol:protein length:64 UBA/UBX 33.3 kDa protein  ali model follow..  20  2...................................................................................................................................................................................................................................................................................................................................SSGSSGAELTALESLIEMGFPRGRAEKALALNQGIEAAMDWLMEHEDD. 51
26 -13.4004bj5_C mol:protein length:202 DNA-BINDING PROTEIN RAP1  ali model follow..  9  1..............................................................................................................................................................................................................................GASNSYAIPENELLDEDTMNFISSLKNDLSNISNSLPFEYPHEIAEAIRSDFSNEDIYDNIDPDTISFPPKIATTDLFLPLFFHFGSTRQFMDKLHEVISGDYEPSQAEKLVQDLCDETGIRKNFSTSILTCLSDLMVFPRYFLNMFKD. 150
27 -13.3001dv0_A mol:protein length:47 DNA REPAIR PROTEIN HHR23A  ali model follow..  20  1.......................................................................................................................................................................................................................................................................................................................................GSQEKEAIERLKALGFPESLVIQAYFAEKNENLAANFLLSQNFD. 45
28 -13.3002crn_A mol:protein length:64 UBASH3A protein  ali model follow..  16  2...................................................................................................................................................................................................................................................................................................................................SSGSSGSSPSLLEPLLAMGFPVHTALKALAATGRAEEALAWLHDHCND. 51
29 -13.2002dna_A mol:protein length:67 unnamed protein product  ali model follow..  18  2.........................................................................................................................................................................................................................................................................................................................SSGSSGPSHSLQAPEVRFSKEMECLQAMGFNYNANLQALATDGDTNAAIYKLKSSQGF. 61
30 -13.2004v1n_Q mol:protein length:734 TRANSCRIPTION INITIATION FACTOR IIF SUBUNIT ALPHA  ali model follow..  5  561........................................................................................................................................................................................................................NKENEPSVKKEEDIDSLSKSKKSSPKKQQKKTANAHVHKEPNLRVKSIKDCVIILKGDKKVLKSFPEGEWNPHAAKIKDISGNESNAVSAPIKKEKPLESIVVQEKETPAPLITEQDIIDAIGDGKVNVKEFGKSIRPGAENKKLMFAIVKKLCR. 718
31 -13.2002d9s_A mol:protein length:53 CBL E3 ubiquitin protein ligase  ali model follow..  17  1.................................................................................................................................................................................................................................................................................................................................GSSGSSGQLSSEIERLMSQ-GYSYQDIQKALVAHNNIEMAKNILRE..... 46
32 -12.8005fyw_Q mol:protein length:735 TRANSCRIPTION INITIATION FACTOR IIF SUBUNIT ALPHA  ali model follow..  6  566........................................................................................................................................................................................................................NKENESPVKKEEDSDTLSKSKRSSPKKQQKKATNAHVHKEPTLRVKSIKNCVIILKGDKKILKSFPEGEWNPQTTKAVDSSNNASNTVPSPIKQEEGLNSTVAEREETPAPTITEKDIIEAIGDGKVNIKEFGKFIRRGAENKKLMFAIVKKLCR. 723
33 -12.7002cos_A mol:protein length:54 Serine/threonine protein kinase LATS2  ali model follow..  14  2...................................................................................................................................................................................................................................................................................................................................SSGSSGVNRQMLQELVNAGCDQEMAGRALKQTGSIEAALEYISKMSGP. 51
34 -12.7002ooa_A mol:protein length:52 E3 ubiquitin-protein ligase CBL-B  ali model follow..  18  1...............................................................................................................................................................................................................................................................................................................................GSGPEAALENVDAKIAKLMGE-GYAFEEVKRALEAQNNVEVARSILRE..... 48
35 -12.7002do6_A mol:protein length:53 E3 ubiquitin-protein ligase CBL-B  ali model follow..  17  1.................................................................................................................................................................................................................................................................................................................................GSSGSSGNVDAKIAKLMGE-GYAFEEVKRALEAQNNVEVARSILRE..... 46
36 -12.7001oqy_A mol:protein length:368 UV excision repair protein RAD23 homolog A  ali model follow..  10  215............................................................................................................................................................................................................................HGSVQESQVSEQPATEAAGENPLEFLRDQPQFQNMRQVIQQNPALLPALLQQLGQENPQLLQQISRHQEQFIQMLNEPPGELADISDVEGEVGAIGEEAPQMNYIQVTPQEKEAIERLKALGFPESLVIQAYFAEKNENLAANFLLSQNFD. 366
37 -12.6001f4i_A mol:protein length:45 UV EXCISION REPAIR PROTEIN PROTEIN RAD23 HOMOLOG A  ali model follow..  21  2..........................................................................................................................................................................................................................................................................................................................................EKEAIERLKALGFEESLVIQAYFAEKNENLAANFLLSQNFD. 43
38 -12.6002dkl_A mol:protein length:85 Trinucleotide Repeat Containing 6C Protein  ali model follow..  19  1......................................................................................................................................................................................................................................................................................................................GSSGSSGGMKTSGKQDEAWIMSRLIKQLTDMGFPREPAEEALKSNNNLDQAMSALLEKKVD. 62
39 -12.3001z96_A mol:protein length:40 UBA-domain protein mud1  ali model follow..  23  2........................................................................................................................................................................................................................................................................................................................................PGLNSKIAQLVSMGFDPLEAAQALDANGDLDVAASFLL...... 40
40 -12.3005oqm_Q mol:protein length:747 Transcription initiation factor IIF subunit alpha  ali model follow..  6  578........................................................................................................................................................................................................................NKENESPVKKEEDSDTLSKSKRSSPKKQQKKATNAHVHKEPTLRVKSIKNCVIILKGDKKILKSFPEGEWNPQTTKAVDSSNNASNTVPSPIKQEEGLNSTVAEREETPAPTITEKDIIEAIGDGKVNIKEFGKFIRRGAENKKLMFAIVKKLCR. 735
41 -12.0005nnr_C mol:protein length:133 HypK  ali model follow..  13  3......................................................................................................................................................................................................................................................AAEDRQPADIVEGATAGDVEEEVAPAAKSAEDRKAAAALSKLDAHADEDMAPAREVDQEAVKNAMSALSGASTEKKEVKKVKVDPADVNLLVEELELSKAKATELLKAHGDAIKAMKAYIQPA... 126
42 -11.9002knz_A mol:protein length:53 Ubiquilin-4  ali model follow..  21  1................................................................................................................................................................................................................................................................................................................................GPLGSMPEVRFQQQLEQLNSMGFNREANLQALATGGDINAAIERLLGSQLS. 53
43 -11.8001wr1_B mol:protein length:58 Ubiquitin-like protein DSK2  ali model follow..  21  1..........................................................................................................................................................................................................................................................................................................................PGISGGGGGILDPEERYEHQLRQLNDMGFDFDRNVAALRSGGSVQGALDSLLNGD... 57
44 -11.2003cz6_A mol:protein length:168 DNA-binding protein RAP1  ali model follow..  9  1...........................................................................................................................................................................................................................................................................GAIRSDFSNEDIYDNIDPDTISFPPKIATTDLFLPLFFHFGSTRQFMDKLHEVISGDYEPSQAEKLVQDLCDETGIRKNFSTSILCLSGDLMVFPRYFLNMFKD. 105
45 -11.2002jy5_A mol:protein length:52 Ubiquilin-1  ali model follow..  21  1..............................................................................................................................................................................................................................................................................................................................GSPEFQNPEVRFQQQLEQLSAMGFLNREANLQALATGGDINAAIERLLGSS... 52
46 -10.8002qho_B mol:protein length:53 E3 ubiquitin-protein ligase EDD1  ali model follow..  34  1.................................................................................................................................................................................................................................................................................................................................GSIPASVIPEELISQAQVVLGKSRSVIIRELQRTNDVNLAVNNLLSRDDE. 52
47 -10.6006c95_D mol:protein length:129 Huntingtin-interacting protein K  ali model follow..  14  8......................................................................................................................................................................................................................................................DMATEGDVELELETETSGPERPPEKPRKHDSGAADLERVTDYAEEKEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMTEMEISRAAAERSLREHGNVVEALIALTN..... 129
48 -10.5002dah_A mol:protein length:54 Ubiquilin-3  ali model follow..  20  1.................................................................................................................................................................................................................................................................................................................................GSSGSSGHFQVQLEQLRSMGFLNREANLQALATGGDVDAAVEKLRQSSGP. 51
49 -10.5002myx_A mol:protein length:75 Coupling of ubiquitin conjugation to ER degradation protein 1  ali model follow..  20  1................................................................................................................................................................................................................................................................................................................GAMGPQGSTQNALRRTGRVNGGHPVTTQMVETVQNLAPLHPEQIRYSLENTGSVEETVERYLRGD... 66
50 -10.1005iy6_S mol:protein length:517 General transcription factor IIF subunit 1  ali model follow..  3  342........................................................................................................................................................................................................................SEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTSEQTVNVLAQILKRLNP. 502
51 -9.7502mgw_A mol:protein length:52 Next to BRCA1 gene 1 protein  ali model follow..  14  1.................................................................................................................................................................................................................................................................................................................................GPLGSSEDQTAALMAHLFEMGFDRQLNLRLLKKHNNILQVVTELLQLNNN. 52
52 -9.2904un2_B mol:protein length:48 UBIQUITIN DOMAIN-CONTAINING PROTEIN DSK2  ali model follow..  17  1...................................................................................................................................................................................................................................................................................................................................GSPEERYEHQLRQLNDMGFFDFDRNVAALRSGGSVQGALDSLLNGD... 47
53 -9.2202dal_A mol:protein length:62 Protein KIAA0794  ali model follow..  22  3.............................................................................................................................................................................................................................................................................................................................SGSSGGSAASSALKGLIQQFTTITGASESVGKHMLEACNNLEMAVTMFLDGGGS. 57
54 -9.1606etx_R mol:protein length:356 INO80 complex subunit B  ali model follow..  10  95........................................................................................................................................................................................................................PRSPSPLMVVDNEEEPMEGVPLEQYRAWLDEDSNLSPSPLRDLSGGLGGQEEEEEQRWLDALEKGELDDNGDLKKEINERLLTARQRALLQKARSQPSPMLPLPVAEGCPPPALTEEMLLKREERARKRRLQAAR-RAEEHKNQTIERLTKTAAT. 248
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.