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Query: [P] COG0004 Ammonia permease, from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MFQKILIIGVSTLLLLTSPIMGNAWAQVPGTTPPADTGDTAFMLISAALVLLMTPGLAFFYGGFVRSRNILNTLMMSFVLMAIVGVTWVLWGYSLSFAPGLPFIGGLQWFGLNGVGLETTGYLQGSEPANVVSYAGTIPHQAYMIYQAMFAIITPALISGAIAERMSFRAYCLFVLLWSTFIYTPLAHMVWAKGGFLGLYGGLGALDFAGGTVVHISSGVSALVAAIVLGPRKTHPDRLSPPHNVTFILLGAGLLWFGWFGFNAGSALSVASSTSGSFITNPATTAFVATNTSAAAGALMWLILEGVLRGKPTAVGAATGAVAGLVGITPAAGFVTPLASILIGFITAFVCFYAVSFKHKLNVDDALDTYPVHGVGGTVGAILTAFFATAEVNSGGKNGVLKGNFGELGVELAAIVIAYVIAAVGTWIILKIIDATVGLRVKEEAEYQGLDISEHGEEAYNSEFSDRIVPLast
1 -111.000PF00909.21; MEP2_YEAST/33-444; Ammonium Transporter Family  ali follow..  35  1........................................GWIGVASAGVWIMVPGIGLLYSGLSRKKHALSLLWASMMASAVCIFQWFFWGYSLAFSHNTRGNGFIGTL----------EFFGFRNVLGAPSSVSSLPDILFAVYQGMFAAVTGALMLGGACERARLFPMMVFLFLWMTIVYCPIACWVWNAEGW---LVKLGSLDYAGGLCVHLTSGHGGLVYALILGKRNDPVTRKYKPHSVTSVVLGTVFLWFGWMFFNGGSAGNATI---------RAWYSIMSTNLAAACGGLTWMVIDYFRGRKWTTVGLCSGIIAGLVGITPAAGFVPIWSAVVIGVVTGAGCNLAVDLKSLLRIDDGLDCYSIHGVGGCIGSVLTGIFAADYVNATADGGWINHHYKQVGYQLAGICAALAWTVTVTSILLLTMNAILKLRLSADEEELGTDAAQIGEFTY.......... 412
2 -6.660PF00510.18; COX3_NEUCR/12-269; Cytochrome c oxidase subunit III  ali follow..  13  9.......................................SPWPLNTSVCLLNLTTTGALSMHNF---NNIHYLYYIALIGLVSAMFLWF-LGIILFIVSEALFFLAIFWAFFHSALTPTVELGAQWPPIGIEPVNPFELPLLNTVILLSSGATITYAHHALIKGEREGALYGSIATILLAIIFTGFQGVEYSVSSFTISDGAFGTCFFTGFHGIHVIIGTIFLAVALWRIFAYHLTDNHHVGFEGGILY--VDVVWLFLYIS................................................................................................................................................................................................................ 252
3 -6.610PF06609.13; Q8NII4_FUSAU/1-598; Fungal trichothecene efflux pump (TRI12)  ali follow..  9  45....SFAGFSLNVCATYFVLQASASALPNILQDIGQSENQGLFSTLWTMGQAVSILVMGRLTDRFGRRPFV-----------IATHIIGLVG-AIVGCTANKFNTLLAAMTLLGVAAGPAGSSPLFVGELMSNKTKFLGLLTVSIP--TIVMSAGPYFGQRLSIQGNWRWIFYIYIITSAIAVLLIVVWYHPPS--ARKRDELAKLDWIGIFLV--SVGVSLFLLGVSWG---GKPNSPWNSSKIIGLMTSGLGSLVVFALYEVFGKPVQPIIPPALFKDTRGFVCILLISSIMGAMNLCLTIIYPQQVINIFGSSLKNWQETAWMTATASFGTW---GVMILGLVGALWLTAFLGAMSSVNRDNKNAAIALSFFSGFVGWAQDITMLMVQFITTDEDLGVAFSVVAASRPFFGSIFTAAFISLYSNQYPKEIGS----HLTSAMRGTDIPQAS................ 489
4 -6.070PF06570.11; Q8DXY5_STRA5/5-213; Protein of unknown function (DUF1129 topsan)  ali follow..  15  44................................................................................................................................................................................................................KGITARSLLGAPTTWAASFTERPEDKARVSVQKNTNPWLMWLDTSLLFLGLVTALNGLMLLFGQSNVNTG--------LISILTLGFGGGAAMYVTYYYIYRHMGLVMLVWFALFAVVPLLPAT-KLPEVVLFIIALASFGLRFY---LQRKYNIQSS........................................................................................................ 209
5 -5.690PF00822.20; EMP2_MOUSE/1-165; PMP-22/EMP/MP20/Claudin family  ali follow..  11  38..............................................................................................................................................................................................................................................................LWRVCTNSTNCTEINELTGPEAFEGYSVMATMILSTILSCISFLIFLLQLFRLKQGERFVLTSIIQLMSCLCVMIGASIYTSYGYSFILAWVAFAFTFISGLM................................................................................................................. 164
6 -5.510PF01184.19; A7TND9_VANPO/71-277; GPR1/FUN34/yaaH family  ali follow..  23  50....................................................LIVGLAMFYGGLMQ---TIAGIWEIALENTFGGTTLCSYGFWLSFG---------------------AIYIPWFGILEAYTAKPSDLNNALGFYLLGWAIFTLGVVICTM--KSTVLFFGLFFMLFMTFLLLCIAS-------------------FSGRHSVQVAGGVFGVITAFI.................................................................................................................................................................................................................................................. 181
7 -5.310PF12273.8; K1X614_MARBU/45-169; Chitin synthesis regulation, resistance to Congo red  ali follow..  16  2.........................................WVALILVVIFFLLMGYLFSIT---RRRRQR--------------------GLAPMYGTG.................................................................................................................................................................................................................................................................................................................................................................................. 37
8 -5.300PF13330.6; G3PLY1_GASAC/1308-1396; Mucin-2 protein WxxW repeating region  ali follow..  11  1...............................................................................................................................................................................................................................................................WSPWYDTTFPTLGTSGGDSETYEKLREAGHKICAKPSQIQCRAEKFPNVTIDNVGQVVQCDLAEGLTC................................................................................................................................................... 68
9 -5.300PF07758.11; K9TUT1_9CYAN/52-222; Protein of unknown function (DUF1614 topsan)  ali follow..  12  45...................................................................................................................................................................................................................................................................VALNVGGGLIPVLVALYQFRHANPLAIVLVTAIVTI---VSYYAARVVPGIGIQMNPLLAPITAAIASAFITRGIHAAPVAFAGGVLGTLIGADILHLKEIQRMTPGV--LSIGGAGVFDGIALCGLFA.................................................................................. 168
10 -5.300PF05452.11; CLAVC_STYCL/1-80; Clavanin  ali follow..  14  1............................................MKTTILILLILGLGINAKSLEERKSEEEKVFH-LLGKIIHHVGNFVYGFSHVFGDDQ................................................................................................................................................................................................................................................................................................................................................................................. 56
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.