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Query: [F] COG0005 Purine nucleoside phosphorylase, from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLKYEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALGVEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDKDLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVANHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYELast
1 -80.400PF01048.20; Q4DQ97_TRYCC/13-261; Phosphorylase superfamily  ali follow..  19  2.....................VGVFGGSGVYQLHN---------LNEVKYYAIETPFGRSGDICVAKVGGVDCAFLPRHGVGHVLNPSENYRANVYAMKLLGVRYLIAINAVGSLDSNYQPGDLVLVDQIIDRTTGRKSTFFEDGIVATSAAFRKLARDAVHRTFPGLAAGTEGWRLHQGTSVTMEGPQFSTKAESLMNKQLGGHLIGMTTATEAKLAREAEMAYLVIAMVTDMDAWSDAPHVTEANVRKTLEQNVDKSRTCTLEVIS... 249
2 -9.640PF06516.11; U7PQZ1_SPOS1/35-361; Purine nucleoside permease (NUP)  ali follow..  13  1..................SPKVLII--SLFSPEADVWYKNLPSSDLGNLMDVNVTAPGLSMLF-VHCVADGSICQMT------TGESEINAAATVMAA-DLKETYFLIAGIAGINPKYGTLGGVALAKYTVQVALQYEFDAREMPA--PGNAYGTEVLSETLRDLAVGFASKANLSVVKCDTV--TSDVYEEVTKVWTNGTGEYCMTAQEDSAVLEVLVRLAIRAILMRTGSDFDRPPPNETAFDIADQNGFEIAIDNIYLAGVEIVRGI. 314
3 -9.400PF12692.7; Q2K041_RHIEC/1-158; S-adenosyl-L-methionine methyltransferase  ali follow..  9  18....LNAITALVEDIEGPVLEFGLGNGRTYDHLREKFPGRRIIAFDWEVRSYSASTPEPQ-DMVTGNIRDSGQAFLGIGAALAH-------------TGHDEIDAVTLTWLPQLMAGVLAPNGIAVSGLPLEHPDLTALPLPEGIKEGRYFL....................................................................................................................... 155
4 -6.720PF17923.1; Q2K731_RHIEC/95-207; Tetracyclin repressor-like, C-terminal domain  ali follow..  16  4...............................................................................................................................................................ERLRSLVHAFLRSECEEAAMRVALHDAAPFYRDAPEAQAARASGDRII-QEVLPSVPEASRALAGDLIVTTLATVGKQFSEAPRSLGEIETYAEAMAEMYAAYLEKL..... 113
5 -6.140PF01645.17; AGLUS_ARCFU/111-479; Conserved region in glutamate synthase  ali follow..  12  76.YGAISYQAFKSLAMAASEFGTLFNTGEGFGVDPEYLNVAAVVEIK----IGQGAKPGIGGHLPGEKVTGTDALSPAPQHDIYSIEDLSMLIYALKEATNYEKPVSVKIAAVHNVAAIAS--DIIAIDGLRGGTGAAPKMIRD---------NVGIPVELALAAVDQRLRDE---GIRNKASILVAG-GFRCSADVVKAIALGADAVYIGTPALVAMG-HTGICNWGICTQDPYLAKRLNPEITAKRLVNLLRAWSHEIKEMLGGM..... 366
6 -5.720PF13578.6; Q0BWI5_HYPNA/77-191; Methyltransferase domain  ali follow..  9  2....................EFGVAGGNSIRQIAS-RTSKTVHGFDSFEGLPEDWAGHLERRGAFTQKRQLPVKLHVGWFDATLPGMLAENAGPVSLLHIDCDLYGGTKYILDTAGDRLQPGSIVMFDEY............................................................................................................................................. 115
7 -5.630PF08645.11; PNK1_SCHPO/69-220; Polynucleotide kinase 3 phosphatase  ali follow..  12  1.............................................................KFIAFDLDGTLIKTKSGRVFSKDAADHPSVVPKLKALYQDNYSLVIFSNQNGIPRKPSAGHTFQMKIRAIFESLDLPIVLYAAILKDKFRKPLTGMWNSFLKDV------NRSIDLSFIKYV---GDAAGRPGDHNSTDLKFAENIGIKETPE......................................................... 149
8 -5.590PF14488.6; D4IPL3_9BACT/51-219; Domain of unknown function (DUF4434 topsan)  ali follow..  9  16...................................................................................QNWGVKEWDADFKAMKQMGINTVVLIRAGLG-SWIAAPFDCLLRTGKVKYPPVDLV------------------------EMFLALSDKYGMDFWFGTYDSCYHWHVGEYEKEIELN--------MQLIDEVWAKYGHHKSFRGWYLSQEISRRTRNVSKIYAAMGRHAKEISGGLKTMISPYIHGV. 169
9 -5.510PF04871.13; GOGC6_ARATH/791-914; Uso1 / p115 like vesicle tethering protein, C terminal region  ali follow..  9  18...........................................................................................................................................................................EFDLKSLSDAYNSLEQANYHLEQEVKSLKG-GESPMQFPDIEAIKEEVRKEAQKESEDELNDLLVCLGQEESKVEKLSAKLIELGVDVDKLLEDI..... 111
10 -5.470PF02571.14; K9PRS2_9CYAN/2-241; Precorrin-6x reductase CbiJ/CobK  ali follow..  11  1....................RVLILGGTGDAELAARVAAIEGVEATSLAGRTREPSIPLGDFRIGGFLRQMRIDLLIDATHPFATQISCNA---VDAASEVGVPRLMLIRRPWQKVSGIEVDTVEAAAKALPLQAQRVFL-----TVGRQELGTFANLKDIWFLMRIIDLPTPDAVMPPGLILCDRGP-FALHHEREIIIHHKIDTIGDATYAKIIVARELGLQVVMVN.......................................... 220
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 2 5 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.