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Query: [E] COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family, from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MYNTLNNKEDISLVSNNFGFLRLPVHFNPVETDAEWVITGVPFDASVSGRAGTRFGAEAIRRASVNLAWEHCRFPWDFDVRERLKIVDCGDLVYSFGDNQNFVEELEAHATALLKAGKRCLTFGGDHFITLPLLRAHAKHFGKLAMIHFDAHTDTYENGSRYDHGTMFYHAPNEGLIDAAHSVQIGIRTEFDRNLPFTVLSAPQVNEESVAQTVAKIKEVIGDLPVYLTFDIDCLDPAYAPGTGTPVCGGLSTDRALKILRALKDVNIVGMDLVEVSPAYDQSDITALAGATLALEMLYMQGAKKGLast
1 -93.800PF00491.21; Q164F5_ROSDO/34-308; Arginase family  ali follow..  39  1.................................LDVAIVGIPMDIGTSWRSGTRFGPKEVRAESAMIRPYNMGT--GAAPFDSLQVADIGDLAINTFSLAKSLKIIEESYHAILNYDAMPLAIGGDHSITLPILRAMHKRHGPVALVHVDAHADVNDEMFGETHGTVFRRAYEEGLILPDKTYQVGLRGTGARAWGFQQFPAQELWHRSLTGLGGEIRRDIGSTPVYVSYDIDSLDPAFAPGTGTPEIGGLTTPQAMELIRALKGLNIVGADLVEVSPPYDASGNTALVGANILFELIC....... 275
2 -12.900PF12640.7; A7UTP5_ANOGA/103-265; UPF0489 topsan domain  ali follow..  12  1........................................................................................................................IFVVEDHHEVLTFLYRCLGSLQGNRIVHFDSHPDMDDLLDSISIENWLMPTVFAGHVERIVWIKPPWSEQIPKGKYAFHVGEFEGSEVCSVEEYPVAEDTDLAQGYILDIDLDYF....................................................................... 163
3 -8.150PF02882.19; FOLD1_ARATH/184-349; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain  ali follow..  15  37...................................................................................................................AGKNAVVIGRSNIVGLPMSLLLQRHDATVST----VHAFTKDPEHITRKADIVIAAAGIPNLVRGSWLKPGA----------------------IDVGTTPVEDSSCEFGYRLVGDVCYEEALGVASAITPVPGGVGPMTITMLLCNT........................................... 160
4 -7.440PF05045.12; A1A3K0_BIFAA/42-543; Rhamnan synthesis protein F  ali follow..  13  298.............................................................................................IFTVGSEENAKLVRERCKGLPYNVDVRVI-GRDVSALLIGAGKDCLKYDYVCFA----HDKKVTQLSPYSIGDGFAYKCFENILGSKALVHAGLLAPTSPNHADYFGNFASLWGPNFEGTKKMLEETLG-----VKVPLNPYKEPIAP------LGTMFWFRP-KALHQLFDIDWKYEDFPPEPNKIDGS------MLHFIERAYGYLPQANG 501
5 -6.860PF06080.12; Q8YZS2_NOSS1/8-210; Protein of unknown function (DUF938 topsan)  ali follow..  9  6.................................................................................................ATQRNREPILEVLLQVLPASGTILEIAGEHAI------FFAPRLKPRKWLPSDPNPELRASITAWIAQFPSDNLYPPVELDASQPIWSVERDAILQDAPIAAIVNHISPWSACLGLLAGAGRILPPGGILYLYGPYKQGGEHTAPSNNPEWGVRNLEDVIAAAKQ------QNLQLHKTYQM--PANNLSVVFQR.............. 203
6 -6.210PF01750.18; Q8TS31_METAC/26-151; Hydrogenase maturation protease  ali follow..  11  1.....................................................................................................................................................................AVVESLKGLELPENVTVVDAGLGGP---------------------HFVFTLLNPESTKTLII---VDIADFGGEPGESYRDAHSWDLAEPLQYIKDDIRIRVLACQKKYVSTPEMVIGITDEVQRAI............. 116
7 -5.740PF14736.6; H3CL70_TETNG/36-302; Protein N-terminal asparagine amidohydrolase  ali follow..  11  2............................................................................................PLVEVDPKCLLYVQQREFAATTPEDQSVSVIGSDDATTCHLIVLRHTGSGAVCLAHCDG-------SNTWTEVSLLVKAVISLNGSKEGRLELHLVGGFNDDSKTS------------HELSFNILAAFHMQKNDIHL-ITEINDTVVDGIHRPVVYGIGV--------NVKTGEVFPSVFPHKGPAEELRSTRTFTGGEMV............ 179
8 -5.520PF05575.11; Q56677_VIBCL/1-286; Vibrio cholerae RfbT protein  ali follow..  7  67.......................................................................................................LGMRHWIVNHCKHDTTYIDIGGTFCGI------AARHITQGKIIAIEPLTEMENMNVQLNNPLVEFHHFGCAIGENEGENIFEVYEFDNRVSSLDKVKNSQVLVRKLSSLDISPTNS------VIKIDAEGAEIEILNQIYE-QRSNRTFDEIFNIINSKFGSKAYFIHPLSSAEHPEFNKATQDINGNICF........... 282
9 -5.460PF13362.6; Q8Y0S6_RALSO/228-334; Toprim domain  ali follow..  14  3..........................................................................................................................................................................YIVESPINALSVECCHLPE-----------GTAAFALRGTANVDKIDWTFLRGKRVVIALDHTDPVNERT----GMRPGLAAAWKLSEALTAA-DIGAMLVDMQDWEEGEDINDVLQAHGA............... 107
10 -5.300PF05050.12; C3Z6H9_BRAFL/38-225; Methyltransferase FkbM domain  ali follow..  8  2..........................................................................................................................CGANVASTVQLFRETYPGGTDYIIHSFELDARLAPYFASYSNHVLHCPVAVAGKDGNITAYTESAEERDDAKAGRQLGVRNVIPMVDLSKWIQENTTP--EDYVIFKLDVEGAE-----------------YEILEKMIKEGTFRWIDKFYGEFHGSLPVPNWPIERRLELKSTL-----ASLG 185
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 2 5 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.