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Query: [E] COG0014 Gamma-glutamyl phosphate reductase, from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLEQMGIAAKQASYKLAQLSSREKNRVLEKIADELEAQSEIILNANAQDVADARANGLSEAMLDRLALTPARLKGIADDVRQVCNLADPVGQVIDGGVLDSGLRLERRRVPLGVIGVIYEARPNVTVDVASLCLKTGNAVILRGGKETCRTNAATVVVIQDALKSCGLPAGAVQAIDNPDRALVSEMLRMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIYVDESAEIAEALKVIVNAKTQRPSTCNTVETLLVNKNIAYSFLPALSKQMAESGVTLHADASALAQLQTGPAKVVAVKAEEYDDEFLSLDLNVKIVSDLDDAIAHIREHGTQHSDAILTRDMRNAQRFVNEVDSSAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWIGIGDYTIRALast
1 -65.100PF00171.22; BETB_ECOLI/15-479; Aldehyde dehydrogenase family  ali follow..  15  32.VDRAVKSAQQGQKIWASMTAMERSRILRRAVDILRERNDELAKLETLDTGKAYSETST-----------VDIVTGADVLEYYAGLIPALEGSQIP--LRETSFVYTRREPLGVVAGIGAWNYPIQIWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYSEA----GLPDGVFNVLPGVGAE-TGQYLTEHPGIAKVSFTGGVASGKKVMANSKEVTMELGGKSPLIVFDDADLDLAADIAMMANFFSSGQVCTNGTRVFVPAKCKAAFEQKILARVERIRAGDVFDPQTGAWVAPTVFTDCSDDMTIVREEIFGPVMSILTYESEDEVIRRANDTDYGLAAGIVTADLNRAHRVIHQLEAGICWINTWGESPAEMPVGGYKHSGIGREN----GVMTLQSYTQVKSI......... 465
2 -28.600PF07368.11; Q9VI33_DROME/97-311; Protein of unknown function (DUF1487 topsan)  ali follow..  13  9..................................................................................................................................................................................................................................ILCEDGDINCALHYLVES--LHDPFACNAVATLFLQESILEEFVDRIRDRLEPLSTDISGHPVYIMTLE-SPMLVYDLSHRYLADGPTG-VITLHTFRTMKEAVELQAEPLNFTSVCIWNEKLAAAYELVARLSPLIFTINCYNLNEITLPFVCNFNSAKIIDGY---HYESLTFKGKRKVVVHPVGTI.. 214
3 -25.100PF05893.14; Q9KV99_VIBCH/423-818; Acyl-CoA reductase (LuxC)  ali follow..  12  1...............LANQPLEAILGLINEARKSWSST--------------PELDPYRHTGLNFLACEPNRLKNLLD--SALNGQRAFLDNFLPRKDISHS---SQKAMPRGIVSHWLSGNVPLLMFALVQSILSKNANILKVSASESQALPVLLATFKGLSYTDDLLGTLAVVYFDRHQTKIAEKFSAN--ADVRIAWGGREAIESVSGLPKKYDILFGPKLSMMVVSDKAIRKLIRRAATDSSVFDQFACASPHTIFVEKG-PKEFAEKLASAMDKALVRLPTQVPDIGQAKHLRWTVLFDEGIELVEPTYQRVITVKAVDNVFDVVDSVHED---QTVGLAMNGEKRLRFANEIMLKGAMRC---------PDVGYMTHFDSPWD-----GVVALDRMVR............. 395
4 -8.090PF00815.20; C8W1L7_DESAS/17-425; Histidinol dehydrogenase  ali follow..  12  3................HMAGKEAAAAIVAEIIKTVREQGDRALCAYTADFDGQLKVIPEEIEEAYGLVEKTTLESICLARDNIASFHRKQLEKSWFAPSDNGVILGQLVRPLARAGIYVPGGFSSVLMNAIPAMVAGEIVMVTPPGKDGKLNPYTLVAAAEA--------GVTEIYKAGGAQAIAALTETIKPVDKITGPGNITLAKQQVYGQVGIDMLAGPSEVLVVADETADASYVAADLLSQAEHDVLASAVL--LTPVESLAEKVREEVARQTELL------------------------PRRDIVTRSLTDYSAIVITRDLAQAVQMANRFAPEHLELMVKEPFNLLCQIT---NAGAVFLGSYSPEPVGDYWAGPNHVLPTGGTARFYSPLSVDTFIKKSSII........ 375
5 -5.060PF07564.11; D3R250_MAGIU/451-525; Domain of Unknown Function (DUF1542 topsan)  ali follow..  23  9.LTKVADDKIATLNQNKDLSESERQTAIKRVNDEKDAAINNIKKATDNAVDQAKENGIAE..................................................................................................................................................................................................................................................................................................................................................................... 68
6 -4.750PF06245.11; A5GEX4_GEOUR/4-411; Protein of unknown function (DUF1015 topsan)  ali follow..  60..EPVYVQGRANLARFMGTQGERECYYVYRQKMGGITQTGLVVCAGVDDYQGGTIKKHELTRADKEEDRVKHIDYLDANDE-FYTYKNDPTITALIAETTTGAPVYDFTTDDGVSHTLWLVAEQERIEQLTSRFAAIPTLYVADGHHRSAAASRVRDLRKAQNPAHTGNEEYNYFLTVIFPDNEMNIMPYNRVVKDLNGLSITEFMARVGEKFDISPLSAPLKPER-QFGMYLGGKWYELLAKEGSFLESDAVARLDVSILQDNLLSPILGVRNPRTDQR------------------------------------IHFVGGIRGLDELVRMVNSGEHEVAFALYPTSIKELMELA---DADKIMPPKSTWFEPKLRSG...................................... 403
7 -4.740PF14194.6; E7GQ72_CLOSY/5-60; Cysteine-rich VLP  ali follow..  16  7.........................................................................................................................AVKKMTRAACANNDCGNCLLLDDGETCVCVQSISYSLLCRYFREAVLPAD...................................................................................................................................................................................................................................................... 56
8 -4.600PF09888.9; H1Z2H4_9EURY/18-178; Uncharacterized protein conserved in archaea (DUF2115 topsan)  ali follow..  13  18.TLDLRRMQWNFSGSVKGIEPSYKKKLEKMITGHLHETWENIRLMNQQGSFSQMKD-----------LLPENNREFWEMVALKCSDKDGSTRIRFLKFLLAGFCIFVKKIPPHPVGMPFPGGDSVQ--------FIEGIYYCPVREKANDVDSALCPFC.................................................................................................................................................................................................................................................................. 156
9 -4.570PF00501.28; Q65NK4_BACLD/471-862; AMP-binding enzyme  ali follow..  14  32.......................................................................................................QLARRLKARGLAAIMMERSLEAAVSMLAV-LKAGGVYVIDPGYPEERIRFLLEDVLTKDSPQISLEGYEVVDAEKEDAANLVHANKPGDLAYYIYTSGSTGKPKGVMVEHRNIVRLVKNAGYIPLKSDVKMAQTGAVSFDASTFEVFGALLNGGTLYPVPKETLLDGKRFRVFLEETGITT-TSPLFNQLAQQDPGMFATLNDLIIGGDALVPGI-VNRVKRESPELSLWNGYGPTEN-TTFSTCFFIDQAYERTIPIGKPIGNSTAYIVDEQPIGVPGELCVGGDGV-ARGYLNQPELTDEKFV......... 354
10 -4.540PF11304.8; V5U9V8_9BURK/81-181; Protein of unknown function (DUF3106 topsan)  ali follow..  13  58LTPEQRQLARESYQNAKTLPPERKAQVWQQYQELTEEQKKRLAE..................................................................................................................................................................................................................................................................................................................................................................................... 101

FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 2 5 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.