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Query: [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase], from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDPHGCLHEAVSAHRDTSSADKSQEVKEKIVAEDTTLTTAQLMVQCLENEGVEYIFGLPGEENIRFVDALGDSTIRFIVVRHEQGASFMADIYGRVTGKAGVCISTLGPGAINLLLGTADAFTDSTPLVAISAQVSLNRIYKETHQVVDLLNMFKPVTKWAEMIIGSAAIPEMMREAFEKAQTSRPGAVYLCVPEDVESISGLTGLRPLARSDEADSMPGSAQITRAAQVLQEATKPIILAGHGAVRDYAGDALVRFSERLRIPVATTFMGKGIFPDDHPNSLGTIGFMQHDYVNFGFDEADVIVCVGYDLQEFDPVRINPNADKKILHLHRYPAEIDAHYPVTVSVEGNLSAALDGLAAIITPKEGLDAEDRKIRNLLREELEYGARADAYPVKPQRLVSDIRAAMGDSDIALVDTGALKMWMARLYPTYQPNTCVISNGLATMAFAVPGAIGAKLAYPDRKVLAVTGDGSFLMNSQELETAIRERIPFVVLVWVDDAYGLIKWKMDLELGRHSFVDFGNPDLVKYAESFGARGYRIEVAADLLPTLKKALAEDVVSVVVCPVDYSENIRLTDKLGQLTQPILast
1 -63.600PF02775.21; Q6LZH8_METMP/393-541; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain  ali follow..  40  1...............................................................................................................................................................................................................................................................................................................................................................................................................................DVGQNQMWMAHYFQTSAPKSFLSSGGQGTMGFGFPAAIGAKFARPDANVIAVTGDGGFLMNSQELATIAEYEIPVIVVIFDNRTLGMVYQWQNLYYGRQCAVHLGTPDFLKLAESYGIGALRVEKPEDINEAFKTALNSGKPYLLDI..................... 149
2 -58.800PF02776.18; A6TD15_KLEP7/6-190; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain  ali follow..  20  1....................................LSAAELLLHRLQALDVAYIFINSGTDYPPVIEAWAKARPELVICPHENAAIGMAHGYYLGTGKVQAVMVHTNVGLANAACGVINLANSNIPVLIFGGRTPISEHSHFGCRNRDQAALIRESVKWDFELRLADQIGEHVDRAWAIASSLPKGPVYLSLPREPLCETFAVD.......................................................................................................................................................................................................................................................................................................................................................................................... 184
3 -43.700PF00205.22; Q2G625_NOVAD/195-332; Thiamine pyrophosphate enzyme, central domain  ali follow..  28  1...............................................................................................................................................................................................................................IAEAIELIAKAKAPVFYTGGGVINAEAARLLRELQSLTGAPVTSTLMGLGAFPADHPAWLGMLGMHGTYEANMTMNRADLVVCIGARFDDRVTGRLDFSPNSKKIHIDIDRASINKTVQVDLPVIGDCGKVLAQL................................................................................................................................................................................................................................. 138
4 -23.700PF02552.16; O67557_AQUAE/619-788; CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit  ali follow..  16  1..................................................................................................................................................................................................EDMSRLPIVRETSTEIGFINGQKVSFEEALQVAVELLSKAKRPTLIVGPLVLWAWNEEAKKKGEIIKRLKEKYPNLNIHLLPDYKPKNKKVDFSREVDPPNPHLSEHDLTLMIGVHRTDFTIRMLKKYTDTKIVTLCTLYGHPDADVS................................................................................................................................................................................................................................................. 154
5 -19.900PF16582.5; D3VJ42_XENNA/183-397; Middle domain of thiamine pyrophosphate  ali follow..  10  15...................................................................................................................................................................................................................EPWLIQPEIHIIAKAEDWDLWRQKRGIVLAGRM--DAEEGKLVARWAKEMGWPLIGDVLSQTGQPLPNADLW------NHPRVQDILSQGQLVIQFGAGLTGKRVLQWEKCQPEQYWIVDPIIGRLDPANHRGRKFTCCVADWLREHPAHLTPAHS-SSWADELAIWAKKASECVATTLAGKFSEAAVAYQLHQLLPEQGQLFV........................................................................................................................................................................ 215
6 -11.300PF01855.19; KORA_ARCFU/14-229; Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg  ali follow..  15  1............................................RGAINAGCNFFAGYPITPSSEIAHGMAKFGGVFIQMEDEIASISAVIG-ASMAGAVAMT-ATSGPGFSLMQEGMGYAAITESPVVIFNVMRAGPSTGIPTAPSQGDAMQAGDYPIVVLAPASVKDMYYLTVEAFKIAFRFS--PVIVLSDEIVGHMRESVALPP....................................................................................................................................................................................................................................................................................................................................................................................... 170
7 -9.340PF00676.20; ODBA_BACSU/20-321; Dehydrogenase E1 component  ali follow..  14  101.......................................................................................................................................................................................................................................................................................................................................................................................................................................................TGSSPVTTQVPHAVGIALAKKDIAAFVTFGEGSSNQG-EGANFAAVHKLPVIFMCENNKY----------AISVPYDKQVACENISDRAIGYGMPGVTVNGNDPLEEARERARRGEGPTLIETIS................... 227
8 -7.870PF13292.6; DXS_HELMI/5-280; 1-deoxy-D-xylulose-5-phosphate synthase  ali follow..  15  1..................................................................................................................................................................................................................................................................................................................................................................LSRISNPGDLQRLSATELDQLAKEIREVIIQTTSKNGGHLAPNLGVVELTLALSPKDKIIWDVGHQSY--YNHFHTLRRYKGMAG-NTGHSSTSISAALGFAFARDDGAVIAVIGDGALTIALEALNHAGHAGNDMIVVLNDNEKLSRIRTDPRYFRNKEEVEEIVRRILVVPGILFEELGFSYHNLSQLREVMTNACRLKGPILVHVLT................... 276
9 -6.960PF02324.16; GTFB_STRMU/269-1074; Glycosyl hydrolase family 70  ali follow..  9  147...........................SNPVVQAEQLNWLHFLMNFGNIYANDPDANFDS------VDAVDNVDADLLQIAGDYLKAAKGIHKNDKAANDHLSILEAWSDNDTPYDGDNMINMDNKLRLSLLFSLAKPLNQRSGMNPLITNSLVNAVPSYSFIRAHDSEVQDLIRDIIKAEIN--PNVVGYSFTMEEIKKAFEIYNKDLLATEKKYTHYN--ALSYALLLTNKSSVPRVYYGDGQYMAHKTINYEAIETLLKA-ITSVRYGKGALKDRTTRTSGVAVIEGNNPSLRLKASDRVVVNMGAAHKNQAYRPLLLTTDNGIKAYHSDTNDRGELIFTAADIKGYANPQVSGYLGVWVPVGAAADQDVRVAASTAPSTDGKSVHQNAALDSRVMFEGFSVVIAKNVDKFAEWGVTDFEMAPQYVSSTDGSFLDS--VIQNGYAFTDRYDLGISKPNK------G------TADDLVKAIKKGIKVMADWVPDQMYAF................................................................................. 670
10 -6.810PF09364.10; PHK_BIFA0/17-382; XFP N-terminal domain  ali follow..  14  139..........................................................................................................................................................................................................................................................................................................................................................................................................................................................GELGYALSHAYGAIMDNPSLFVPCIIGDGEAETGWQSNKLVNPRTDGIVLPILHLNGYKI---------NPTILARISDEELHDFFRGMGYHPYEFVFDNEDHLSIHRRFAELFETIFDE..................... 257
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.