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Query: [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid), from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDIWLADESQAERVRGELARFIENPGDPRYLAASWQSGQTNSGLRYRRFPFLATLRERAGPVTWIVMLACVLVYIAMSLIGDQTVMVWLAWPFDPVLKFEVWRYFTHIFMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITVISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALLWIVAGWFDWFGMSMANGAHIAGLIVGLAMAFVDTLNARKRTLast
1 -55.000PF01694.22; O83947_TREPA/47-200; Rhomboid family  ali follow..  18  1................................................................................................................................VRYHRMYWQIFTYQFVHSGVWHLLFNMLGLVFFGQTIEKKMGSSEMLLFYLLVGTLCGAGACAALNVLLLGASGSIFAILFLFSVMFPTALIYLWVIPIPAPLLIVGYILFEIFDLFFDNVSHLTHLLGVLFAWGYIRIRFGIKP... 154
2 -35.800PF08551.10; RBL19_ARATH/44-142; Eukaryotic integral membrane protein (DUF1751 topsan)  ali follow..  17  7.....................................................................................................................................FAWNLITSGYFELSVYGVVFSTVSLLFMGKFLEPVWGSTEFLKFIFVVNFLTYLCVFVTA-MPFAGFHGVLAGLLVGI................................................................. 97
3 -35.000PF12122.8; GLPG_CROS8/1-84; Cytoplasmic N-terminal domain of rhomboid serine protease  ali follow..  73  1MLMINSFDNPRLAQAFVDYMATQGVILEIQRHDTWDIWLADEAQAERVKAELSYFLAHPGDPRYLSASWQTGQLNAGLRYRSYP................................................................................................................................................................................................ 84
4 -18.300PF16733.5; Q9HZC2_PSEAE/1-69; Rhomboid N-terminal domain  ali follow..  22  3AVQVLKFPLSVDLAGFVGLLRRLNVPHRVEESGQQVLWVPDERLAEQVRELYRRYPEGDPQATLEA.................................................................................................................................................................................................................. 69
5 -15.300PF04511.15; DERL1_CAEEL/10-202; Der1-like family  ali follow..  17  2.............................................................................................PIVTRYWFLASTIIPLLGRF-GFINVQWMFLQWDLVVNKFQFWRPLTALIYYPVTFHWLMMCYFLYNYSKALESETYRGRYLFMLIFNWFFCSGLCMALDIYF---LLEPMVISVLYVWCQVNKDTIVSFWFGMRFPARYLPWVLWGFNAVLRGGG--TNELVGILVGHAYFFV......... 176
6 -11.400PF11085.8; YQHR_BACSU/9-172; Conserved membrane protein YqhR  ali follow..  13  25.................................................................................................................................FCGGVLWSFVAYIAYLFHFSEISPNMIL-FVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKTMWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIY------------LYGLFVGYSISFEYNELNSEKL 161
7 -10.200PF01569.21; A7EIU4_SCLS1/134-294; PAP2 superfamily  ali follow..  14  1..................................................................................................................................................AVIGLLYSLITAAVFQVFLKWLIGGLRMYDRTICTGDEDEIDDSLESFP-SGHSTAAFAGFVFLSLYLNAKLKVWSNYHPAMWKLIVTYAPILGATLIAGALTIDEYHLAGAIIGTVMAFSA........ 152
8 -8.750PF09413.10; Q0C4D4_HYPNA/1-66; Putative prokaryotic signal transducing protein  ali follow..  12  1MEEVLRTNDPVKLSYAQHLLTEAGIEYFVADQHISAVLMVREAELAKARLALSGV............................................................................................................................................................................................................................. 65
9 -8.560PF14150.6; Q81Z77_BACAN/16-96; YesK-like protein  ali follow..  19  7........................................................................................................................................................ITIILVFAISYLLKKRFPDKQFDIIFALSLILLCLASFPVTMMVIGGWEGMGYGFIGFFVLLG............................................................. 69
10 -8.280PF11780.8; K9TN42_9CYAN/8-148; Protein of unknown function (DUF3318 topsan)  ali follow..  22  35.......................................................................................................................................WARERPIYINFDLWRKL-DLLLLRTVSWLLGVKWFKPDLYQGVVIAGLLGTLVELVEGDAVGVVTAGGLTALAGVQIWRSTHRSDREIEADQAAIQIAL.......................................... 137
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.