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Query: [M] COG1004 Predicted UDP-glucose 6-dehydrogenase, from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKVTVFGIGYVGLVQATVLAEVGHDVLCIDIDANKVADLKKGRIAIFEPGLAPLVKENYEAGRLQFSTDAQAGVAHGVIQFIAVGTPPDEDGAADLKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKVHQVIQAILEQRGEKIDFSVVSNPEFLKEGAAVADCKRPERIVIGIDTDDSGALELISELYEPFNRNHDRMLVMDIRSAELTKYAANGMLATKISFMNEIANIAERLGADIEKVRQGIGSDSRIGYHFIYSGCGYGGSCFPKDIQALIRTAEDKGYKPQLLQAVEQINNQQKYKLTEFIKSHFNSQLAGKTFAVWGLAFKPNTDDMREAPSRVVMESLWEAGATIQAYDPEAMDETQRIYGARDDLRLMGTKESALQGADALIICTEWQSFRAPDFDMIKSRLKHPVIFDGRNLYDPERLNSRGFTYYGIGRGVSINLSLast
1 -56.400PF03721.14; UGDH_CAEEL/10-205; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain  ali follow..  35  2.KVVCVGAGYVGGPTCAMIAHKCPTVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLF-FSSDIPKAIAEADLIFISVNTPTKMYGAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREA-QKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGE-SSPEGLQAVAELVR................................................................................................................................................................................................................................................................. 195
2 -55.100PF00984.19; B0SMB7_LEPBP/199-292; UDP-glucose/GDP-mannose dehydrogenase family, central domain  ali follow..  60  1.............................................................................................................................................................................................................RSAELTKYACNAFLATKISFVNEIANLCDALGANYDDVRKGMGTDSRIGRQFLYAGIGYGGSCFPKDVRALLRTAEEVNAPMHIIQSVEDVNEK..................................................................................................................................................... 94
3 -50.100PF03720.15; A1RC15_PAEAT/319-420; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain  ali follow..  28  1.................................................................................................................................................................................................................................................................................................................................AILGVTFKPNSDDVRDSPALDIANKLFDEGAEVTVYDPAGNVNASRRS---PQHHYVTSMGDAVKNADLILLLTEWDEFKTLTPEGLAAQTGTRKIIDGRNILEA...................... 102
4 -14.600PF03446.15; Q8FTI1_COREF/15-184; NAD binding domain of 6-phosphogluconate dehydrogenase  ali follow..  15  1.QIGVVGLAVMGSNLARNFARNGHTVAVYNRSTDKT---------------DKLISDYATDGNFIPTKTVEDFVAALEKPRRAIVMV------QAGAATDAVINQLADAMEEGDIIIDGGNALYTDTVCREKEMAARGRHF---VGAGISGGEEGALNGPSI--------MPGGPKESWEALGPLLESI................................................................................................................................................................................................................................................................... 156
5 -13.900PF01210.23; GPDA_COXBU/7-162; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus  ali follow..  18  1.PIAILGAGSWGTALALVLARKGQKVRLWSYESDHVDEMQAEGV-------NRYLPNYPFPETLKAYCDLKASLEGVTDILIVVPS----------FAFHEVITRMKPLIDAKTRIAWGTKGLAKGSRLLHEVVATELGQ----VPMAVISGPSLATE.................................................................................................................................................................................................................................................................................................. 137
6 -11.500PF10100.9; H6NF63_9BACL/6-429; Staphylopine dehydrogenase  ali follow..  10  2.RVLILGTGPASVQLAVTLKNKWNCCIGIVRSEPFFTALDESGRRVRADIQNEKHQAMQGECIVDVFQGYGTITGEWDTLILAVTT----------DAYVAVLKQIHGELLKRVRCMLLLSPTFGSNRLVRHYMNGIQSSAEI-STYSCATRWAGPRPSHQVITTAVKKKVFIGSTHGRSPAIESLCGLYEKLLEVMDSPMEAESRNISLYVHPPLFMNEISLGITQYLIRDMLAAWKEMMSILEQLHFEGINLLKFMTD------DNYPVRLESLSRHDIEHFTELETIHQEYLLYIRYTSLLIDPFS---EPDQEGRYFDFSAVPIRSIYWDIPRMPKEDYIKIIQGIARHLNVSCPTIDK..................................................................................... 383
7 -10.600PF02558.16; Q9K9R6_BACHD/6-154; Ketopantoate reductase PanE/ApbA  ali follow..  13  1..VAVIGSGSIGLLLYAYLKLANWPALLVTNRPEQADHLNKEGLTFVAK------SGEHQPISVTATPLSSFSAEEAEVGFITVKS----------FAVKALLPQLQRKKWDGLVFFQNGMTHLEILRQI.............................................................................................................................................................................................................................................................................................................................. 112
8 -9.550PF14833.6; Q67QX0_SYMTH/163-284; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase  ali follow..  13  2..............................................................................................................................................................................................................AGSVAKLCNNLLVGIHTAAMAEAFVLGTKAGVDPKALYEIISNATGHSAQIARNIPAFSIDHLHKDVALAVELGKDENVRMVLGAVTQQL........................................................................................................................................................ 101
9 -9.490PF03807.17; Q21544_CAEEL/2-98; NADP oxidoreductase coenzyme F420-dependent  ali follow..  21  1.KIGFIGAGKMAQALARGLINSG--------------RITADNIIASSPKRDEVFLDQCKALGLNTTHDNAEVVQKSDVVFLAVKP----------VHVSKVASEIAPALSKEHLVV---SIALG................................................................................................................................................................................................................................................................................................................................... 97
10 -9.340PF02056.16; CHBF_ECOLI/6-188; Family 4 glycosyl hydrolase  ali follow..  13  1.KVVTIGGGSSYTPELLE-ELPVSELWLVDVEGGKPK------LDIIFDLCQRMIDNAGVPMKLYKTLDRREALKDADFVTTQLRVGQLPARELDERIPLSHGYLGQETNGAGGLFKGLRTIP------VIFDIVKDVEELCPNAWVINFTNPAGM---EAVYRHTGFKRFI-GVCNIPIGMKMFIRDVLM................................................................................................................................................................................................................................................................. 182
11 -9.230PF00056.23; MDH_CHLAA/3-142; lactate/malate dehydrogenase, NAD binding domain  ali follow..  14  2.KISIIGAGFVGSTTAHWLAAKE-DIVLLDFVEGVPQGKALDLYE---------ASPIEGFDVRVTGTNNYADTANSDVIVVTSGAPRKPGMSVNADITRACISQAAPLSPNAVIIMVNNPLDAMT.................................................................................................................................................................................................................................................................................................................................. 124
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Flexible structure alignment by chaining aligned fragment pairs allowing twists. Bioinformatics. 2003 Oct;19 Suppl 2:II246-II255.