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Query: [E] COG2902 NAD-specific glutamate dehydrogenase, from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGYRNNPKREKQIEKARQQAIAENVQFLDPGILYGRASADDIEYYSAEMLAASAAHSFEALSHWTGDAPHISITTVEGVSPRDIPVTVLTIIGRNMPFLYDSVMGEVTSSYRGLYLAVHPILVRDDEAQGYRLAEPEDDPAENISLIQLHIAPLTPQAASALEERLRFVLTQVQSAYRDWRPMLTKLDEALDELSKRGSSRRKTERTEAVEFLNWLRNDNFTFLGMRDYTYSGKGKNAKIERGDGVGLGSLSDPDVRVLRLGKNAVTTTPEILAFLDGPDFLIVTKANVKSIVHRRAYMDYIGIKRFDEDGNVIGELRIVGLFTATAYTRSVKQIPLLRAKVADVERHFGFDPNSHSGRILQNTLEAYPRDDLFQIETDLLIRFIEQIMELSDRPRVRVLARIDRFDRFVSAIIFVPREEYNSYVREKIGDYLSRVYDGHISAYYPAFPEGAVARVHFIVGRTEGKTPRIAQDKLEDAVSDIAARWIDHFVALSEPGAPVLDVDQAYQEAFTPEEAIGDMPDILAAANGEPVRIEFYQQEGQSDDTLSLKIFHRDGHLPLSRRVPLLENLGFNVISERTFDIGVVSEGEKRDIVLHDMELSVAAGTTLDLPHYGPKLEEAFLAAFSGKVDNDNFNRLILACGLNVREVSVLRAYARYLRQTGIVYSQEHISETLYKYPDISRNIFALFKAGFDPSIEEKKRVKKLAEIHKAIEAALSGVPNLDEDRTLRRYVNAIDATLRTNYFQKNADGTPRDLLAFKFDPKHLDGLPDPRPFREIFVYGTEVEGVHLRFGKVARGGLRWSDRGQDYRTEVLGLVKAQQVKNAVIVPVGAKGGFFPKNLPAGGSRDEVFNAGREAYKTYIRTLLSITDNIVDDAIVPPADTLRLDGDDPYFVVAADKGTATFSDTANGLAHEAGFWLDDAFASGGSAGYDHKKMGITARGAWETVKRHFREMDTDIQTTPFTVAGVGDMSGDVFGNGMLLSEKIRLIAAFDHRDIFIDPDPDTDKSFAERKRLFELPRSSWQDYDRSTLSAGAMIISRSEKSVTLTPEAVAAIGLDKSVATPFEIMTAILKAPTDLLWFGGIGTYIKAAVETNAEVGDRANDPIRVNATELRAKVIGEGANLGITQKGRIAYALAGGRCNSDAIDNSAGVNSSDVEVNIKIALASAVNSGRLTMPKRNQLLASMTPDVAQLVLRNNYQQSLAISLTERLGLANREELGRLMGALEATGQLNRKVETLPNNAEFSERYASGKPLTRPEIGVLLSYAKLTLFDALVASPLPDEPYLQHLLLDYFPAKMQKNYANDIKAHRLHREIVATALANAVVNRGGPGFVQKLADASGLLAADVVKAAVIVEDGFGLKRLWTEVDALDGKVGGQVQNGLYATITRIFSDASRLYLQTGSAGAAAGDMATEIERLKTAIKTLSPAATKYRRELGVTEIDGVPSGLLEELDTLSLLVYVPEIMRIAESAGTTLARAAESYATVSSTFRVARLLDASQRITPADHYESLALLRSQDQISSSRRRIVISALTEYAKEKDPVQAWYAADRVRVNRIVSELGALSESGDTNLARLTVAAGLLGDIVQARLast
1 -297.000PF05088.12; A4XWG7_PSEMY/77-1608; Bacterial NAD-glutamate dehydrogenase  ali follow..  40  1......................................................................VRAFNPDEKHGWQSTHTAVEILHGDIPFLVDSVRMELNRRGYSIHTLQNSVFSVRRDANGELLEITQGEGVLQEALMFLEIDRCSSAELKTLEKAIHEVFGDVRMSVADFQPMKAKARELLAWLDRAKLKVDKAELEEIKVYLNWLLDNHFTFLGYEEFTVAPSADGGTMVYDEKSLLGLSKRLRTGLTA---EELHIEPEAVAYLREPQLLSFAKAAVPSRVHRPAYPDFVSIRELDAKGNVVKECRFMGLYTSAVYAESVWNIPYIRRKVDVIKQRSGFDSSAHLGKELAQVLEVLPRDDLFQTPVDDLFNTALAIVQIQERNKIRVFLRRDPYGRFCYCLAYVPRDVYSTETRLKIQQVLMDRLQATDCEFWTFFSESVLARVQFILRVDPKNKTQIDPVRLEKEVIQACRSWKDDYASLNVLAEFPGGFPAGYRERFAPHSAVVDMQHLLSLSNDKPLVMSFYQPLAQGDQQLHCKLYHADTPLPLSDVLPILENLGLRVLGEFPYKLRRN---DGREFWIHDFAFTYAEGLDVDIQQLNDTLQDAFIHIVGGDAENDAFNRLVLIAAMPWRDVALLRAYARYLKQIRLGFDLSYIASTLINHADIAKELVRLFRTRFYLARTAEDLEDKQQKLEQAILAALDNVAVLNEDRILRRYLDLIKATLRTNFFQADASGAAKSYFSFKLSPRLIPEIPRPVPKFEIFVYSPRVEGVHLRFGDVARGGLRWSDREEDFRTEVLGLVKAQQVKNAVIVPMGAKGGFVPRKMPVGGSRDEVMAEGIACYRIFISGLLDITDNLKEGEVVPPVNVVRHDADDPYLVVAADKGTATFSDIANGIAAEYGFWLGDAFASGGSAGYDHKGMGITAKGGWVSVQRHFRERGIDVQKDNVTVIGIGDMAGDVFGNGMLLSDKLQLVAAFNHMHIFIDPNPDAAKSFAERKRLFDLPRSSWADYDSKLISEGGGIFLRSAKSITITPQMKARFDIAADKLAPTELLNALLKAPVDLLWNGGIGTYVKSSKESHADVGDKANDALRVDGRELRAKVVGEGGNLGMTQLGRVEFGLHGGASNTDFIDNAGGVDCSDHEVNIKILLGEIVSGGDMTEKQRNKLLAEMTDDVSELVLGNNYKQTQALSLAERRARERVGEYKRLMNALESAGKLDRALEFLPSDEELNERATNGQGLTRPELSVLISYSKIDLKESLLKSLVPDDDYLAREMETAFPEILTEKFGDAMRRHRLKREIVSTQIANDLVNHMGITFVQRLKESTGMSAANVAGAYVIVRDLFRLPHWWAQIEALDYKVPAELQLQLMDELMRLGRRATRWFLRSRRNELDAARDVAHFAPRIEALVGRLDEREQWLARYQSFVEAGTPEELARVVAGTSHLYTLLPIIEAADVTGKDASEVATAYFAVGGALELSWYLQQITNLPVETNWQALAREAFRDDLDWQQRAITVSVLQMPQEIEARVALWLEQHHRLVERWKAMLTELRSATGTDYAMYAVANRELMD..... 1532
2 -19.000PF00208.21; DHE3_ORYSJ/176-408; Glutamate/Leucine/Phenylalanine/Valine dehydrogenase  ali follow..  19  1............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GGSLG----RDAATGRGVMYATEALLTEYSESISGSTFVIQGLGNVGSWAA--KLIHQKGGKIVAVGDVTGAIRNKSGIDIPALLKHRS----EGGSLEDFYGAEVMDAAELLVHE------------------------------------------CDVLVPCALG---------GVLNRENAAEVKARFIIEGANHPTDTEADEILAKKGVIVLPDIYANSGGVVVSYFE------WVQNIQGFMWDEEKVNRELQKYMKNAFQNIKDMCKSQNCNL-----RMGAFTLGVNRVAKATLLRG.................................................................................................................................................................................................................................................................................................................................................................... 233
3 -13.000PF02812.18; R6WCN3_9CLOT/34-162; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain  ali follow..  27  21...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FEGFRIQHSTLAKGGVRYHQNVN--VDEVRALSAWMTFKCAVIPYGGGKGGIVCRP------REMSKGELERLTRTYIDKISAIISPNTD-------------------IPAPDVGTNA........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 117
4 -8.120PF02514.16; Q2JMZ0_SYNJB/187-1302; CobN/Magnesium Chelatase  ali follow..  10  97..................................................................................................HYVAMVQELESRGARVVPVFAGGLD-FSKPVNEFFWNAQKTAPIVDVVVSLTGFALVGGPARQDHPKAVEALQRLNRPYMVALPLVFQSTE------------------------EWAASDLGLHPVQVALQIAIPELDGAIDPII---LSGRDAATGKAHAMQDRIELIAARAIKWAN-----LRRKPKLEKKI-------AITVFSFPPDKGNVGTAAYLDVFASIH-------------RVMQALAHNGYDLGPELPKTPQELMESILHDPQAQYASPELNVAAKLSVREYEALTPYVKAIEQYWGPAPGHLNTDGQNLLIYGKHFGNVFIGVQPTFGYEGDPMRLLFSRSASPHHGFAAYYTYLEKVWGADAVLHFGTHGSLEFMPGKQIGMSGECY-------------PDNLIGSLPNLYYYAANNP------EATIAKRRGYACTISYLTPPAENAGLYKGLQEL--EMIGSYQTLREGARGIAIVNAICDNLDKDVDLPAGDAAQLSLEERDTVVGKIKLMEIESRLLPCGLHVIGAPPTAEEAIATLVSIASIDRPEEGILGLPRILAQS-DIDEIYRNRDRGHLADTELLDRINKACQKAVAALVQEQTDAQGRVSRVAKLNFFNMGRQAPWLAVLKEAGYPQVDPDLLKPLFEFLEECLKQITADYELGSLLRALEGEYILPGP---GG--------------------DPIRNPNVLPTGRN------------------------IHALDPQSIPTAAAIKSAEIVVERLLAREMSSNG----GKYPETISVVLWGTDNIKTYGESLAQVLC-----------LGVDALGRVNKVE--LEELGIDV------VVNCSGVFRDLFVNQMLIDRAVKLAAAAVEKHALQQAEELGLTLEQAATRVFSVENSSWEELREMYLSRKSFAFGSNLPNQQMRQLFEASLTVDVTFQNLDSSEISLTDVSHYFDADPTKLVQSLDGKAPSAYMADTTTPNAQIRRLDARTKLL----N-----EGMLKHGYEGVREIAKRLVNTSGWSATAGAVD-----------------------NWIYEETNETFIKDEAMRQ---RLMNLNPHSFRRIVGSLLEVHG-RGYWQTSQANI........................................................................................................................................................................................................................................................................................................................................................... 1116
5 -7.000PF17072.5; SPIKE_BRV1/1-1583; Torovirinae spike glycoprotein  ali follow..  10  170................................................................................................PYMANGVRTRVQSPGIQYEIYSYAVYQITPYTQYTVTMPSGTSGYCQQTPLYVECGSWTPYRVHAYGCDKATQSCNYTISSDWVVAFKSKASAIISQLIVALAQKLSRTVGVNKAVYFWFLKQPYHYLSLVNF---------------SPNYALFSPLCKSLRQQSATYSALSYGSPFFVAQESILFSWDYQVNYPVNNQANETFLQLPTTGYLGQTVSQGRMLNLFKDAIFAVVVKQVPVIAYSAFRIEQQTGYLAVKCNG-----------------VIQATLAPHSSRVVLLARHMSMWSIAAAN------STTIYCPIYTLTSFVRLDISTS-----------FHTLAQPSGPIQQVSMPVLSTGAAGVYMHPMIEHWVTLLAQS-------------------SVYQPSMFNMGVNKSVTLTTQLQAYAQVYTAWFLSI------LYTRLPESRRLTLGAQLTPFIQAL-----------------------------LSFKQADIDATDVDTVARYNVLILMWGRKYAAVIYNQL------EWSYPLFKGGVGDSMWFRKKFLVTTKIHQTASHFPFIAGYL-DFLDYKYIPKYKD---------VACPLSTMVPSILQVYETPQL--FVIIVQCVSTTYSWYPGLRNPHTIYRSYKLGTICV--VPYSSPTDVYSSFGFFFQSA--TTDDILPGCVGFVQDSVFTPCHPSGCPVRNSYDNYIICPGSSASNYTLRNYYRTTTPVTNVPIEEVPLQLEIP-----TVSLTSYELKQSESVLLQDIEGGIVV---DHNTGSI-----------GQAYDVSFYVSVIIRYAPPKLELPSTLANFTSCLDYICFGNQQCRGEAQTFCT---SMDYFEQVFNKSLTSLITALQDLHYVLKLVLPETTLELTEDTRRRRRAVDEFSD-TISLLSESGISLPQRTGSILSSAPSLSSISSWHSYSSRTPLISNVKTPKTTFNVKLSMPKLPKAST---STIGSVLSSGLSIASLGLSIFSIIEDRRV-------IELTQQQIMALEDQITILAGYTTKNFEEIQSSLVQDFSQTSALSLQQLSNGFEQITQQLDKSIYYVMAVQQYATYMSSQAVYKTQDMYITCIHSLQSGVLSPNCITPFQICHLYQVAKNLSSGECQPILSISRFYSLPLVTDAMVHNDTY--SNILGSVYKVQPGYIVNPHHPTSLQYDVPTHVVTSNAGALIFDEHYCDRYNQV--------------YLCTKSAFDL---------------AEASYLTMLYSNQTDNSSLTFHPAPRPDPCVYLSASALYCYYSDECHQCVIAVGNCTNRTVTYENYTYP--MDPQCRGFDQITISSPIAIGADFTALPSRPPLPLHLSVNVTFNV--------TLPNELNWTDLVLDSFKDKVYEISKNITQ------HEQILQVSNWASGWFQRLRDFLGLIPAWITWLTLGFSLFSILISGVNIIL... 1572
6 -6.580PF13740.6; D3RP38_ALLVD/3-79; ACT domain  ali follow..  9  1....................................................................................EIVLINVTGEDRPGITAALTAILARYQVPILDIGQSTIH-------------------NALALGLLVELPRSGTDCGVFKELLFSAHTLGLDIR............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 75
7 -6.510PF01551.22; Q7MBF2_CHRVO/304-401; Peptidase family M23  ali follow..  20  8.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YAASAGTPIVA--------------GELVKVARENGYG-NVVMIRHNGKLTTLYAHMSAFGKGIQP---GKVKAGDVIGYVGSTGRSTGAHLHFEVRVNDQPV--DP......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 98
8 -6.250PF10266.9; H2R9P1_PANTR/23-1103; Hereditary spastic paraplegia protein strumpellin  ali follow..  11  1.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NAIIAELLRLSEFIPAVFRLKDRADQQKYGDIIFDFSYFKGPEL---ESKLDAKPELQDLDE------------FRENNIEIVTRFYLAFQSVHKYIVDLNRYLDDLNEGVYIQQTLETVLLNEDGK---------------------LLCEALYLYGVMLLVIDQKIEGEVRERMLVSY-----YRYSAARSSADSNMDDICKLLRSTGY--SSQPGAKRPSNYPES---------------YFQRVPIN---ESFISMVIGRLSDDIYNQVSAYPLPEHRSTALANQALYFEPSILHTHQAKMREIVDKYFPDNW------VISIYMGITVNLVDAWEPYKAAKTALNNTLDLSNVREQASRYATVSERVH---QVQQFLKEGYLREEMVLDNIPKLLRDCNVAIRWLMLHTADSACDPNNKRLRQIKDQILTDSRYNPRI--LDTAQFEFILKEMFKQMLSEKQTKWEHYKKEGSERMTELADVFSGVKPLTRVEKNENLQAWFREISKQILSLNYDDSTAAGRKTVQLIQALEEVQEFHQLESNLTRKFLHQMIRTINIK-EEVLITMQIVGDLSFAWQLIDSFTSIMQESIRVNPSMVTKLRATF-LKLASAL--------LLRINQANSPDLLSVSQYYIIPESMFTLLKIIKLQTHDIIEVPTRLDKDKLRDYAQLGPRY---------EVAKLTHAISIFTEGILMMKTTLVGIIKVDPK--QLLEDGIRKELVKRVAFALHRGLIFELMPKLKELGATMDGFHRSFEYIQDYVNIYGLKSRIINYNVEQECNNFLRTKIQDWQSMYQSRLCREILRITDPKMDQLNTWYDMKTHQEVTSSRLFSEIQTTNGLDRLLCFMIVKELQNFLS.. 871
9 -6.140PF14961.6; W5NL29_LEPOC/12-1308; Broad-minded protein  ali follow..  9  1.................................................LQSLLRHLLESVKERIRGAPSAE----------CAEEILLHLEETDENFFIMYLRHYVENM------------VIEAETECCASGEGQGVGPGQDTLVHAVTRRTRESNILSLKNTMMVAVESLINTFEEDKLRKEETHGKSQHEQLSSHYTDNCSDSDCSF------NQSYAFIKQEQLAIAEKIDSSQPKEVRWEALQTLCCAPPSDVLSCESWTGLRRNLSAALGDPDPAFSDKVLK------------FYAKTFSSSPLNITREIYTSLASQKTSFSTAAGLDISNQDVARLLKKMRL---------LNEFQKEVTSFWIRNPEKEEIIESTLSLLSLNLDQSLKTTSADKVLEPIYFLSMLDIKANWGYYSRTVVLRLLENKYKSLIVAS------------------------------LQQCINYYESCESSCDKTSNIAHVRQQQQTGTTQRMFYTARQLEYTYFVHSVC-----LLGRLLMYTHGRKLFPIKLKRRKDPVTLTDLIVILIRIMYRHPIPYYSEIPHVVVDSLSPACLVMDVLRTLCDRKECAVECAIAVIELLLSPIIALLKGKQVNLTSPETTLT---ADILARIATTERGLSLFLYDGNFIYTEGEGISAAHVIVQFTKKLLADKISVLSEAGPLTSLKGAFIFVCRQMYNTCEGLQVLKPYGLHDCIAEAWKQTVSLSERVPTPVPGDCSSSATQDSQ------NNMVWEETLLDNLLNFAATPKG-LLLLQQTGAINECVTYMFSRFTKKLQV-------GVMVTQVAATAPGVAAIWSSG--FVQAIVLELWSVLECGRDEVRMIHPKSTPMDPIDRSC-------QKSFLALVNLLSSYSAVY--ELLVKQELPNKPEYPLREMPTSIIDLIDRLII---INSEAKIHSLFNFEQSH--TFGLRILLDSLLLLESQYRISEILLQSQKDNVSESSGSEGQFIIDGLSIRNHILVRINLIGGPSERFLPPRVLQKGPDPYPWPMFSTYPLPNCYLHDVPKIVPCKQETEISKFLAFSKNPEKQANKQFCKAMATKPDIIKGNVLADLLEKTTIHLSSSPSECFFLSQDYKALDSSVKNQSTLEQLGIKMSIRYGMYLKLIKEDVEQELMKHCQTFLSQQQIKVKSPLCILIKLITHKSSYPGHDWFASSVFLIMSGDKERALKFL----LPFSNLLASAFLWLPRLHASVHHPVDIAESGIHPIYSCTAHYVEMLLKTEVPLVFSAFRMSGFTPSQICLQWLGQCFWNCTCIVMGPDYQTYIEEILQHTQVQDLQVFLKEEPIFSISNYLEYMESLEQKYRTMVLTDM............................................................................................................................................................................................................ 1292
10 -6.090PF15962.5; A9MQT6_SALAR/12-1138; Domain of unknown function (DUF4765 topsan)  ali follow..  10  4..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QKLNTKGIKTWDTIQYLSALDRAHKDTVFHEQISNLPEEYIHLDEMARD-LNIYEFFFESTAE----------ICEDIKSTLDFYYL--KSPTFRRLV---------NYRVNYSIGNDIDTSKCEVIVSP-----------------------------------------------NYSYQNTEGSSVYLSLPFDKKGFPI---NPESNDCDNNISSEKVLLDLFLKHILYDDLKVDHEVTNLYSNVIYKEIDSTAM--------AHASLCFSQAAVSDKHEL---FNIDSVTVQPKSTEQVIFAGE-EIQKQILFFFERENNFQPATAHKMERNIKNIAVTGLLLSSRLTIADGYG----RKNDNSENKNNFSSDKEPLRYARALPEDHPAPNMEPHGKMIDGIVEHSSFAAGISLFETL--KKIGDEQLMNDYKRGYHELLVFSQTGQWTH-------------------GGRRLTAEYMFNGLIIHLNE--EILINDGGKVSFEHFVREHIEHQYKIYELIARMLVHPIYIRSRIFATRRIASALANESHYTK-VLNQKFPEISSSNFDTFYGKEAIFTALKIVNYYREEKGMSKKMKDLFKRVQLVIRHLSRNGGDKILLSPDGIKYNFSIMRNIIYWCAKITGPVNDKKINALSRKIVVNNETHVKDHIQDCDVLGLMNINKMLRDTVVGLIHEISDIAQSS---LTAEDQHEKQVQALEAFKSKVSSMDG-------QAFVYGFDKVIQEGLWGLIE-----LSFDIDDTVHHRTVSSLSPASRAGLHFLGTIWNIVMSFVPTSSILNRAIVEKSTDVCGYIQDVIRIGMEAAPVAEAKFT-AKYTGLRFVENKIERGVIRSPIQKGSNYKVIESIENIYQKRNNKILELNPEGNDGLYRATGFNKETHGYYKQS............................. 866
FFAS is supported by the NIH grant R01-GM087218-01
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Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Godzik A., Rychlewski L. A support vector machine approach to the identification of phosphorylation sites. Cell Mol Biol Lett. 2005;10(1):73-89.