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Query: [C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase, from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MIDMKLAILGAGCYRTHAASGITNFSRACEVAEMVGKPEIAMTHSTITMGAELKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKVNEVAKELPKPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDMQPGIIDKFIDDIKPGAIVTHACTIPTTKFYKIFEEKHGDLVTKPETLNVTSYHPGAVPEMKGQVYIAEGYASEEAINTLFELGQKARGNAYRLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLGAPAGFAQMMAKESLEQITALMEKVGIDKMEEHLDPGALLGTADSMNFGASADILPTVFEILEKRKKLast
1 -34.500PF02153.17; TYRA_BACSU/20-279; Prephenate dehydrogenase  ali follow..  12  3..................................................................................................LAIKKNHPGKRIIGIDISDEQAVAALKLGVDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGSTKQKVVDYADQVL-------PSRYQFVGGHPMAGSHKSGVALTPGQKTDKQAVEQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFAA----GGFRDITRIASSSPMWRDILLHNKDKILREIDKIRTYVEQEDAENLFRYFKT... 260
2 -30.300PF02737.18; Q2YR99_BRUA2/5-183; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain  ali follow..  14  1..................................................TVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVAS-------------GKLQEEQRADAMKLIRANSMEDLAGVDLAIEAATEDTIKRKIFAQLCPVLNPEAILTNTSSISITRLASTTDRPE-------RFIGIHFMNPV--PVMKLVELVRGIATEEDTFRKSNDFVTALGKTVTVAE.................................................................................................... 178
3 -15.700PF07991.12; ILVC_METAC/15-178; Acetohydroxy acid isomeroreductase, NADPH-binding domain  ali follow..  11  1LKDKTIAIMGYG----------------------------------------------SQGHAHARNLHESGLNVVV-----------------------------------GLRKGSSSWAKAESDGLKVMTVEEAAKAADVIMILLPDEKQASVYYSQIEPSLEAGNALVFAHGFNIHYNQIVPPKDVDVFMVAPKGPGHIVRRTYTEGIGVPGLIAVYQDATGKARDLALAYAKGIGA.......................................................................................................... 160
4 -14.100PF03446.15; Q8FTI1_COREF/15-184; NAD binding domain of 6-phosphogluconate dehydrogenase  ali follow..  14  5......................................................VGLAVMGSNLARNFARNGHTVAVYNRSTDKT------------------------------DKLISDYATDGNFIPTKTVEDFVAALERAIVMVQAGAATDAVINQLADAMEEGDIIIDGGNALYTDTVCREKEMAA------RGRHFVGAGISGGEEGALNGPSIMPGGPKESWEALGPLLESIAAKV........................................................................................................ 160
5 -12.800PF03721.14; UGDH_CAEEL/10-205; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain  ali follow..  10  1.................................................SKVVCVGAGYVGGPTCAMIAHKCPHITV---------TVVDMNTAKIAEWNSDKLPIYEPG------DEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMRVLIGGESSPEGLQAVAELVR.............................................................................................................. 195
6 -12.100PF03201.16; HMD_METTH/245-341; H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase  ali follow..  100  1.......................................................................................................................................................................................................................................................AELLGPVCDMCSALTAITYAGILSYRDSVTQVLGAPAGFAQMMAKESLEQITALMEKVGIDKMEEHLDPGALLGTADSMNFGASADILPTVFEILEK... 97
7 -12.000PF01210.23; GPDA_COXBU/7-162; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus  ali follow..  10  1..................................................PIAILGAGSWGTALALVLARKGQKV----------------------RLWSYESDHVDEMQAEGVNNRYLPNYPPETLKAYCDLKASLEGVTDILIVVP-SFAFHEVITRMKPLIDAKTRIAWGTKGLAKGSRLLHEVVATELGQVPMAV-------ISGPSLA..................................................................................................................................... 135
8 -11.800PF03807.17; Q21544_CAEEL/2-98; NADP oxidoreductase coenzyme F420-dependent  ali follow..  13  5......................................................IGAGKMAQALARGLINSGR-----------------------------ITADNIIASSPKRDEVFLDQCKALGLNTTHDNAEVVQKSDVVFLAVK-PVHVSKVASEIAPALSKEHLVVSIAL........................................................................................................................................................................... 96
9 -11.500PF10727.9; Q743Y6_MYCPA/8-128; Rossmann-like domain  ali follow..  14  6..................................................KVGIISAGRVGTALGVALERADHVVVACSAISH---------------------------------ASRQRAQRRLPDTPVATPPEVAAGAELLLLAVPDSEL-AGLVSGLAATVRAGTIVAHTSANGVGILAPLTR----------QGCIPLAIHP............................................................................................................................................ 121
10 -11.000PF00670.21; SAHH_DICDI/191-351; S-adenosyl-L-homocysteine hydrolase, NAD binding domain  ali follow..  14  1..........................NLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLSKMGARVLVTE-----------------------------------IDPINALQACMDGYQIV-TMETAAPLSNIFVTTTGCRDI---VRGEHFAVMKEDAIVCNIGH........................................................................................................................................................................... 111
11 -10.300PF01262.21; Q9S227_STRCO/141-353; Alanine dehydrogenase/PNT, C-terminal domain  ali follow..  13  1......APQVGAYHLMAANGG---------------RGVLPGGVPGVLAGRAVVIGGGVSGWNAAQIAIGLGFHVTLLDKDITKLREADKIFGTKIQTVVSNAFEL----------------------------EKACLEADLVIGAVLIPGAKAPKLNELVSRMKPGSVLVDIAIDQGGCFEDSHPTTHAEPTFPVHNSVFYCVAPGAVPNTSTYAL------TNATLPYIVELADRGWAEALRRDPALAKGLNTHDGKVVY.................................................................................... 212
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Wyrwicz LS, Godzik A, Kloczkowski A, Rychlewski L. Support-vector-machine classification of linear functional motifs in proteins. J Mol Model 2006 Aug;12(4):453-61. Epub 2005 Dec 10.