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Query: [S] COG5427 Uncharacterized membrane protein, from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEFGVVARWWVFFGVLLVAGLPVASRLLPDAPDRGASVAMPLSLVVVTLATLWVGQVAYGQLVVGGVFVAVLAAAAWLARGGVEIPRKPLLEVVGVFTVAFVFLIVVRAWADGVQPAGGEQFLDFGLLQALDRAGQLPPRDMWFAGERVVYYYGGQLMASIGAHLTDTAPRFAYEPALAGVYAMGCTAAYGLASTIAAGNGGESRPVGVPTAIGGAGVALAVVVLATGVNWLVVAVPAAAAAVVVTRPRRVRAGVLGAFAFGFASNLGPVIRLLAARVDVVRAAVVAAGINADRRPAITPEAFDMWHASRFMETGLNEFPLFAYLNGDLHAHMVSVPVLFVAVAVGVAYYRTPARQRRRRWALLWGGFPVAGAAILTVNTWSLPTVFGVAALAVALADPAPATLLPTGVQRWTRRESAVGQSVQRVLLAVGVAAVGGVLAVVIAWPFVQNVLLAGASNQHLAVLPVPSQAGALVFVHGLFLAAFGAYFVSRVATSVAGWVVAAAAAGAAVAVAVAVGPVVGGVGITAVVLVGPVLGAAWWLRRRNAAGVECVLVAAGAGLVVLVEYVYLADAASYERFNTVFKVYAQVWALWSVAGGVALAGVSERRASTGGLGAVFVVGLVVAASVYGGLAVTTHAANADDASLDALEYAGNAHPGEAAAARWLGDRRRGTRIVAAPGVDPYTWQNPAASLSGVPTVAGWAHAANYHSQAAWEQRVDDIGVVYETTDAASRAAILEKYDVTYVWVGPVERARYEIPDLSADPGIEPVHRTPAVTIYRVTDDELVAPRSGPITVTTTPQAATATAPGAQTARSPARFVTVTSSASTAVTSSQWGTKLRFSLast
1 -110.000PF10060.9; I0I741_CALAS/47-643; Uncharacterized membrane protein (DUF2298 topsan)  ali follow..  17  1.............................................LTGYCFWIAYSLGLLRNDIGGAWLALIGVAIISLAFSALPSLRYILLFELLFLGAFAAWAWVRAHDPAAD--HTEQPMDLMFMHSIRASLTYPPHDAWLAGYPISYYYFGYWLMNMVGLMAGQSAAVAYNLSQAVWFGLLLSGAFGIGYNLVAAAGRRFVAA-------------------------------------------LGGGWVATLLVGLSSNLQGLLEWLHANGVDISWLAAWLQVREVTRQWFISYGWWWWRSSRVLADVIDEFPAFSYILGDNHPHVAAMPFAMLAVAAALVIFLQNSSSNFSSGWGGFLLVAVITGSLLFLNTWDYPPYWLLTTFSIAVGVVGGVVRVKNFLPLQFLPL------LPPLLQTTIAGLALFVAALLLYLPYLLTAQSQVGGL--IPNLFHPTRFSQYVAMFATALLTLTALLTFGWSVFRPRLKVVMLPDGASSYLPFIVERWTAQPFTFLIVGAMTAVALALLVAAPTPLLFVLALAVIGLGLTFTPEVVYLRDNFG-WRMNTIFKFYYQAWLLF........................................................................................................................................................................................................................................................ 597
2 -21.800PF10034.9; H9G3T3_ANOCA/57-723; Q-cell neuroblast polarisation  ali follow..  8  1...............................................................................................ISLAILTSVYVATLHENDLWVSNTECGLYYSYYKQMLQAPSIQHSD---SMRTINMNVYQEVFLSILYTVFQLEPVYFYIYTVFGLQSVYVIALYVTSWLLSGT---------------------------------------------------WLSGVLAAFWYITNRI----------------------------------------DTTRVETIPLRE----NW----------ALPFFAVQTAAITFLLRTHLRPTHEKLTLTALFISTSLFSL----AWQFNQFMLLIQALVLFTLDCLDLLPSKKVTWIYVIQVASLLLVCVLQFFNSMIVGSLLISFNMSALLARKLQETMGTPGCYTILWEASLMSPHGKLVHILLVLSLTFLGNNFIKKVLNLESDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPFNTFMRLSDSLVFYPYIFVVVVMTITAAAVAFQNLSGSANVRYSTMRMKYLWTSHICVFAASGLCSSLYTPQRVSVIRYLTPILILLYLCYKFWPGVMAELSELR----------EFYDPDTVELMNWIKSSTPKKAVIA----GSMQLLAGVKLCTGRVLTNHPHYE-----DKSLRERTKQVYQVYAKRSPEDVHRILRSFGTDFVILEDSI-EEIKRNLPSYTKYFTKAFQNKTFHVYKL............................................................. 667
3 -13.500PF11847.8; V5X6I4_MYCNE/1-670; Alpha-(1  ali follow..  14  1.......................................................................................................MVLTFLQAPGQIAPDTKLDLTARFLARAGDL--------WNSGQAQNQAY-GYLFFFLAGDLLGVPGWVTQRLWWALLLTVGFWGLLRVAEALGIGTTAAR--------------------------------------------------VVAAGAFALS-------------------------------------------------------PRVLTTLGAISSETLPAPWVLLPVIYVL--------RGDPRIRLLAARSAAAVALMGAVNAVATLTGCLAAIIWWAAHKPNRQWWR----------------FTGWWLGCTALAVTWWAVALVLLGRISPPFLDYIESSGVTTRWLSLTEMLRGTDSWTPFVAPTAT---------------------------AGSPLVTGSVAVLATTLVAAAGLAGLAMASMPSRGRLILILFVGVTALAIAAGVQLFLDADGTPLRNVHKLEPLLRLPIALGLAHLLGRIVDAFAHPERDRRVAVGIVILTALAAGTSLAWTGRLTPPGSFEAIPAHWH-------DTAAWLDEHNTDGGRVLVAPGAPFATQVPLQVLGHSPWGVRDSIPLTPPETIRALDSVQ--RLFAAGRPSAGLADILAQQNISFVVVNDLDPEASRSRVMDNSPGLTRVAEFGDVEIYRVDDAHPGPYVTDADTLAAERRRLAGQQPLGPMLLTADAQRAGLPTPLVTVTDTPVARETDYG 647
4 -11.800PF07220.11; D4HSK9_LEPIR/4-673; Protein of unknown function (DUF1420 topsan)  ali follow..  8  3...............FGLVAYPPLSVLYSIF---GFYILKLLGKVKNTWIRWQAPLIGALLLSVILYPLALSALT------------RFLMKSAAIFLSVLGCANICFFVKN-----GTKNLVSISYYSNIFKSIQY----------HSFFEKIGFSLFKLIGFIKNKFNLINKNDVLNVFIILLMIGYGSLDYHIG-------VAIEILNQGKMPVFSGWFHGRLAGSGEVLNALGLAIGAEQFGSLLQFCGLLSIYGILSFYSFAEKFSESDG-------------------------------VWRKIIIIAFLSSPVLVFLVSSPKPQLLQIGMTSFAITLLLEIFSK--IKTDKNKLFAFSLICILIMSATQAK-FSFFLSAFLIGLFSIFSLGSIRLFFY-------------------------GLLISLFFFVLINFPAI---------------------FWKIKNYNSTFIDVLIHPLPGNTFPGVNEFEVSLRNYQDSALIFPLSLIFPNQFGVITTVIGLGLFLIIFVKPIVTQKAFLLSVMIILFVILGS--------------GQKASRFFLEPFVWMLISLIGLNSF--GKWNIRFVKEAVSTGILLQACATLVIISVGIYQLFPGVFSISLREKVMSQYANGYSLMKWVGLTLPKEAVLLSQHRSIALSERKTLSLD--------------------------PFVDFNSAVASPYLKQIKDENVTHILMFGDTSKNTPFSGTKSNQVARNPFNRNDVILVEFQSDKLP....................................................... 663
5 -11.800PF09586.10; Q839W8_ENTFA/19-846; Bacterial membrane protein YfhO  ali follow..  10  2................................................................................................FFIPFLIMAIIYLSI-GIYPGSSRSVLDHASFNNVLHGKQSLFYT-WNASLGLNYLLISYYLGGLFTPLVFFFNNQNMPDALYFLTLLKIGSAGLSFWFLAKQTFKIPKWSH----------------------------------------------VTLSVSYALMS------------------------------------------------FIVAHSELIMWLDA-----FIYLPLVILGIHRLMD---------------KPTLLFVSYFLLFITNYYFGFMIGLFSFLYYFARTFTDWQ-----------------RYKSRIVAYFTTSLLAGGASMIMVLPAVLDLRTNGETLSEIVYDTTKYGSIPFIYIGLLPLIFCLFYFVTKEVPLKNKLLFGSLFVLLIASFYITPLNLFFRYSFLFSFLVILLAGYGWEKFEKDDLGVLSGLILILLAIFALAMGTKGATSYTYVTLTSFVL------TATFLLLYFFGIAFYQLKKAPMQYLVILLLLLVSGEAIINTRAMVT--GILDDWNYASRSLYSEPYPDLKNLVDQTKKENDT----LENLNGVSANDGINYGYSGISMFSSVRNRHSSTYLNALGFRSRGTNLNIRYQNNTLLMDAL--MGIKYN-IAENNPMKFG---------FERQAAAGKYQLYRLADKEIYNVRQPLNDNLGSQTNLLNALANTNERYFTFYQPTMTLQNNVTITQNTAGVTFTEK 644
6 -10.700PF10131.9; R5JZI7_9CLOT/75-690; 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein  ali follow..  11  1....................................................................................................................................................FRYWGPLSYYIMAGLMFLTSGDLLLAYRLIAFVIFVVGGLPWILWGIHENRR---------------------------------------------------VLGTFFGVLWFFM----------------------------------------EHIRIYFTAGNLPQMVTTMLV-----------PYVIWFLWLYV----------RKKNNRAAVGLFVCMTLMSFTHLMVTAIMGVSAFLYLLIDQIWNKDT-------------------RRKIFALIYMICGILTAGIWVIPSLKGGLVTSESGDGSVMSTLIYPLTTSLNPFKRLSAGNDSFYF--------------------------------------LAAVLIAIAGILLARGGKKAGFVFLLIMLACTTPAAYRIL----------VKLPFSQLFWMTRFAPMVYGFFFSACLEWVRLKKKYCVLLAALLCVDSIS----------------CMNLDFYSVATSDETKMEMQQLTELTDQRTAVIDKSSYGSYPSYGISGSSHTMYTYGWAWQ-----GAETGDNIVLLNEALDRKYYRFLFDRAVELGADTVLIRKSDLEKQDITQDAAASGYSMVQEMTTAYTYKRETPENFGTVTGYYGLAIGKYANEMTLLYP----------AFVAGNSDMIEDYSVEELSRYD 489
7 -8.020PF09971.9; B8GDE7_METPE/352-740; Predicted membrane protein (DUF2206 topsan)  ali follow..  10  2...........................................................................................................................................................................................................................................................................................................................................................................YLLLIVFSFALATSHYGLSYLFMLTLFFALLILIISEIGSLGNLRHTIRKQFDWEKRGYTMNFAPRHAGERTVTIDYVMVFTIFALGWYLFISS---------SSALNSITDLFIQFSNNIVVGFMNPETTQGLNVIVTQAATPLHSIGKYIQFVAQFFIMFGIFSLLFRPQKMELGGEYVAVDREYFSFALVNLVLALAGVVLYFSSALNTTRLYQITLIYLAPFFAIGVIEMF-FVRISWYKFNNENAIKALGAFLCIFLLFNTGVIYTIAQDSPTSIALTDNVDYPRFTPLEVAGATWLHQV-GNRTIYSDVPMAT-------------------------------------LESFSGTLSHKIPSETSQLRKSSYIFLGETNKDTTSTSALPYIASRGIIYDNGKTRIY............................................................... 389
8 -7.410PF15440.6; W5NH69_LEPOC/112-758; THRAP3/BCLAF1 family  ali follow..  8  401.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LLQKTLDMREKAALRDESPPRVKIVPGEASRPEVKVKIASLAYDDPSPGTSLTSDRSLA-----------------SALVHSTKREQGFRSIFDHIKRPQAYKNSAESFIQHIVVHHVKEHYFKSTGMSLHERFTAYQKAAE--------GHEVRQKSPEIHRRIDISPSAFRKDRILKEDSHKGEKKSRCDAADLRHDIDRRRKERSR 586
9 -7.390PF04880.13; G7XHM6_ASPKW/134-306; NUDE protein, C-terminal conserved region  ali follow..  17  3.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EDMEQKY---NMAIERSVLLEDEVK---AGEKEREALRIQCQRLRDELSEQKLDNEILQEKLRHEQKPTPLSRTSSSTPQAPEIFDRSPGTSAVSSPLFVRTPMKSSLMGVTAA......... 116
10 -7.210PF12687.7; D6DF47_CLOSC/21-163; Protein of unknown function (DUF3801 topsan)  ali follow..  11  33....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KGKQTV------------KQLIGQNQGVSNIINDPSIRDFERIARKYGVDYAVKKDRSASP---------PKYLIFFKARDADALTAAFTEYTGKKVKKAEKTERPSVLAKLAQFKELLKNTVVDRSRRKE................. 143
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 2 2   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A.; RIKEN GER Group; GSL Members. Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 2003 Jun;13(6B):1376-88.