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Query: [C] KOG1257 NADP+-dependent malic enzyme, from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITELast
1 -76.700PF03949.15; MAO3_BACSU/274-535; Malic enzyme, NAD binding domain  ali follow..  32  1.......................................................................................................................................................................................................................................................................................IQGTGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKRFWCIDRNGLLTDDMDQLLDFQKPYARSRNGDGGGIDLLEVVRQAKPTILIGTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSPFPPVEY-NGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNV-GVPGAPMLPKVEDLRTVSATVAVEVAKTAM................................................. 262
2 -71.700PF00390.19; Q9U1J2_DROME/102-283; Malic enzyme, N-terminal domain  ali follow..  50  1........................................................................................HHRHRRLYYRFIKENIEKSLPIVYTPTVGDVVATYGLNFQQAISLFISIHDKGHIRDLMHNWVDEGVKAICVTDGGRVLGLGDMGANAMGISLGKMILYTALGSIPPSTLMPVCLDVGTDNQALLQDPLYVGARIPRVKGPEYDELVDEFMESAVKCFGNNTFIHFEDFATPNALKFLEKYQ.......................................................................................................................................................................................................................................................................................................................... 182
3 -8.590PF00056.23; MDH_CHLAA/3-142; lactate/malate dehydrogenase, NAD binding domain  ali follow..  15  1................................................................................................................................................................................................................................................................................................................KKISIIGAGFVGSTTAHWLAAKELGD----------IVLLDFVEGVPQGKALDLYEASPIEGFDVRVTGTNNYADTANSDVIVVTSGAPRKPGMITRACISQAAPLSPNAVIIMVNNPLDAMTYLAAEVSGFPKERVI.............................................................................................................................................. 139
4 -6.640PF00670.21; SAHH_DICDI/191-351; S-adenosyl-L-homocysteine hydrolase, NAD binding domain  ali follow..  9  1.........................................................................................................................................................................................................................................................................................NLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLSKMGA-----------RVLVTEID-------------PINALQACMDGYQIVTMETAAP--LSNIFVTTTGCRDIVRGEHFAVMK---EDAIVCNIGHFDCEIDVAWLNANA-GVHIILLAEGRLVN-LGCGTG............................................................................................................................... 161
5 -6.340PF00208.21; DHE3_ORYSJ/176-408; Glutamate/Leucine/Phenylalanine/Valine dehydrogenase  ali follow..  11  8........................................................................................................................................................................................................................................................................................AATGRGVMYATEALLTEYSESISGSTFVIQGLGNVGSWAAKLIHQKGGK-----------VAVGDVTGAIRNKSGIDIPALLKHRSEGGSLEDFYGAEVMDAAVHECDVLVPCALGGVLNRENAAEVKA----RFIIEGANHPTDTEA---------------------DEILAKKGVIVLPDIYANS--------GVVVSYFEWVQNIQGFMWDEE-----KVNRELQKYMKNAFQNIKDMCKSQNCNLRMGAFTLGVNRV.......................................... 225
6 -6.050PF01734.22; Q09D74_STIAD/17-214; Patatin-like phospholipase  ali follow..  12  6.........................................................................................................................................................................................................................................................................................GPSALITLRVLRQLEARFPGFVERAQMFSGTSTGAF-VSLYLAHALSLRQRQGVQAPGCLDIIDGCIAFNERMTRQFKVKARLISGLVPMYDGKAIREILEE-----TFGEAKLCELEKMVVIEAFDSTVWRKATYHQFPPDADFVTTLVDAALASSAFPVLMPIYRSGNTVGRHKNDLMMD-NNS----TAM.............................................................................................................. 195
7 -6.030PF05088.12; A4XWG7_PSEMY/77-1608; Bacterial NAD-glutamate dehydrogenase  ali follow..  11  615...........................LINHADIAKELVRLFRTR--------FYLARKLTAEDLEDKQQKLEQAILAA-----LDNVAVLNEDRILRRYLDLIKATLRTNFFQADASGAAKSYFSFKLSP-------------RLIPEIPRPVPKFEIFVYSPRVEGVGDVARGGLRWSDREEDFRTEVLGLVKAQQVAVIVPMGAKGGFVPRKMPVGGSRDEVMAEACYRIFISGLLDITDNVAADKGTATFSDIANGIAAEYGFWLGDAFASYDHKGMGTAKGGWVSVQRHFRERGIDVQKDNVTVIGIGDMAGDVFG--------NGMLLSDKLQLVAAFNHMHIFIDPNPDAAKSFAERKRLFDLPRSSWADYDSKLISEGGGIFLRSAKSITITPQMKARFDKLAPTELLNALLKAP-KSSKESHADVGDKANDALRVDGRELRAKVVGEGGNLGMTQLGRVFGLHGGASGGVDCSDHEVNIKILLGEIVSGGDMTEKQRNK----------LAEMTDDVSELVLGNNYKQTQA............................................ 1146
8 -5.640PF02558.16; Q9K9R6_BACHD/6-154; Ketopantoate reductase PanE/ApbA  ali follow..  13  1..................................................................................................................................................................................................................................................................................................................VAVIGSGSIGLLLYAYLKLANWPALL-VTNRPEQADHLNKEGLTFVAKSGEHQPISVTAT-PLSSFSAEEAEVGFITVKSFAV-----------KALLPQLQRKKWDGLVF-FQNGMTHLE-----ILRQIPARAICCGIVEIGAKRESDVRVQHTGDGAIWI................................................................................................................... 144
9 -5.590PF07071.11; Q8ELL9_OCEIH/6-221; KDGP aldolase  ali follow..  10  12...................................................................................................................................................................................................................................................................................................................................................................................SDITNAKEIYEATDGHVLIGLLSSNYTSVQEALEDIRVYDKGSISLGLGGGNPEQWKMVADISREYKPRHI---NQVFPKVGYTRAAVNHAQTMINSLVKPTGQPGLVDIATGPTNKSLIIVEVEAAIQLTKEMGGNSLKFFP------TSRLEEYEAVAKACAKEDFYLEPTGGIDVQNSIIEIALQAGVKKVIPHVYS............. 210
10 -5.570PF05221.17; D9SB20_FIBSS/15-498; S-adenosyl-L-homocysteine hydrolase  ali follow..  6  162...........................................................................................................................................................................................................ETDSEEWGVFLA---TCRKIFEKDPKQWTRAREALKGVSEETTTGVHRLYQMAQAKRLKFPAINVNDSVTKSKFDNLYGCRHSLIDGIN---RATDVMMAGKIAVVCGYGDVGKGCAQSLRGQGA-----------RVIITEIDPI-------------CALQAAMEGYEVKTLDEVVS--YADIFVTTTGNTGIISAAQMEKMK---NRAIVGNIGHFDNEIDMAGLKKIPGIKRNEI---KPQYDEWIFADGHSILVLAEGRLLNL--GCATGHPSFVMSASFTNQTIAQIDLWLNAQGTVAGIKYESGVVYTLPKILDEKVARLHLEKLGVHLTRLTQAQADYIGVPVEGPYKADH...................... 482
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 3 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.