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Query: [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family, from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSQNKIERISKEVAERLTTAQVVVSLSSAIRQLIDNSIDAGSTIIDIRVKNNGFESIEVQDNGSGIEARNFDALCKPHSTSKLTQFSDFDKLATLGFRGEALNALCTVSSVSIFTRASDTEIGTRLTYDHSGNIICRQSAARELGTTIIVNKLFETLPVRRKELERSQKREFVKLLSTVQSFALLCPHIKILCTNNINGKKTNLICTPGGTTSIQDVVANLFGIARKIENSKIGSGLIPIQQNQPDVEIMTIHSVPMEEMHFFDLFKIRGFVSSCEHGCGRGTSDRQFVYINNRPVEYSRVCSVINDVYKQFNKKQYPIIVLFIDVPPEKIDVNVTPDKKTVMLEKERHLLAVVRASMMKTYLKIVGSHSTVRSSVEDRRIMNLSQQSFSNASFMSSKSSTPDDFNNTTLNSTYPEDSLLNTSDLLKQRKENRSPPAKKSCPMIRRTEPFHSVPSTSNSRTQRLENFSFTMEPKRVEVSKKIPSKSDKKLTDEELRSAVIEENPLKKAGEIDDIEILEQSQESQDVNESQCSQDSQTSQNSRVSYFTLRPQQKIKFSMKLLREAYSPKTDETDDNTEEAEVSAEKDVLNEITTKINKEENDDAERQLSRSLTKDDFSKMKIIGQFNHGFIICRLRGHLFIVDQHASDEKYNFERLQSSAKLTKQPLFMPTALGFGAVQELIIRENLPIFHANGFDFEFSENDGCIKTFLTARPELLNQQLTNSDLEEILAVVSQYPNQMYRPVRIRKIFASKACRKSVMIGKPLNQREMTQIIRHLAKLDQPWNCPHGRPTIRHLASLPDRAEFELast
1 -33.200PF08676.11; Q3Z791_DEHM1/382-523; MutL C terminal dimerisation domain  ali follow..  22  1........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PLLRLVGQIGGLYLLAEGPDGLYIIDQHAAHERIRYEEIASQSENARQSLLDPFILELNPVQEAMIEKCKSELDLMGFEIE---EFGRRVYRVQSIPAGFTAPQAKALLSELVDNPKDAPA-----EIKERLQRLMACHTAVRAGQVL......................................... 142
2 -26.400PF01119.19; A5CFB6_ORITB/216-334; DNA mismatch repair protein, C-terminal domain  ali follow..  26  1.........................................................................................................................................................................................................................ISEILS-------KNFIDNAISIGIERDE-------------------LSITGFVSVPT--YNKASAEDQLLFVNNRPVKDKLLMTAIRLAYQGLARERYPIVVIFISVAPHFIDVNVHPTKSEVRFHDSSLVRGIIISAIKQAL........................................................................................................................................................................................................................................................................................................................................................................................................................................................... 118
3 -16.900PF13589.6; A5G4D8_GEOUR/22-165; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase  ali follow..  19  2........................EPHSALMDIIDNSVAADALNVKLYVDRNNVARYRVVDDGKGMDEDGIKNAFKLGSDAN----YKQNSLSKYGM-GLKSAGFSLGLRIQIISKTEGQLT........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 103
4 -8.990PF02518.26; O52937_9CYAN/626-739; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase  ali follow..  22  5........................RLQQVVWNLLSNAVTKNGGRVEIRLECVDSQAIKVSDTGKGISPDFLPHVFESFRQA------DATITRKFGGLGLGLAIVRHLVEL-------------------HGGTIYAESPGEDLGATFTVR-----LPL...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 112
5 -5.740PF05086.12; O15924_DICDI/5-925; Dictyostelium (Slime Mold) REP protein  ali follow..  14  508LDFMTIRSINYETFKSIISSERVLNLEQDVKKLKDLLLKKSKKS---TIDDESELLSRVSNH--------------REFATFLYEFINKNKHLSLSKSDNYLKFVDSITSTLCVEYDSNSIEHKIGFINHCRSEISRFQ---PTGDIIKMNSLFSSTPSSEEDLKRKYSLMSSDLSGLLKDKSRFNPSVLISFNNNVSGHCKVFSFGDVSNGFSITNLRNVY--------------VQDSNLYNRYEEYMGKTRVITAFFFAPCLIQLTNFIFQTDKITNDKNISRQI-YINGNTIDSVKFSKVV-----QINSSEFSFTILNISFSSVLISKN----KSTELLRKADKLEQLLKKYIEN-FQKLNTITETEEDIIEAFDFESSAGDDIRNEDEDDEDEDEDDDDDE.............................................................................................................................................................................................................................................................................................................................................................................................................. 921
6 -5.440PF02689.14; HELI_EHV2/2-789; Helicase  ali follow..  7  21..VGRIRGLAAKTVPPLITGTAGAGKSTSISALYQSCLITGATAVAAQNLSNGLKTCPTIYSAFGFKSRHINILPRHGRNAPARDMEGIQRNELCKY--PVISDILALAKMGTPTLWTTN-----IVIDEAGTLSSH--------TAVVFLYWFYNSWLQTPLYKSG----------------------------------AVPCVVCVGSPTQTDAIQSTYNHSMQKHHIQECDNILTF------------------------------LMKHEAVSRYVDLNHNWALFINNKRCTDPEFGHLLKTLEYNLDISPRMVDYIDRFVVPKSKILS--VGWTRLFVSHREV........................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 343
7 -5.250PF03269.14; A0A2H2IKF9_CAEJA/181-356; Caenorhabditis protein of unknown function, DUF268 topsan  ali follow..  15  2..................................QSGVVIGSMQVEVSALVNGAKKILTVE----YNKLTIQEEFRDRMSSILP----VDFAKGWANYADTFNFAASFSSIEHSGLGRYGD-----PMDPIGDIREILKIKCKGGL------LFLGFPLGTDSIVYNAHRIYGRLAMMFYGFEWIA........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 141
8 -5.160PF00834.19; RPE_SYNY3/6-205; Ribulose-phosphate 3 epimerase family  ali follow..  14  31.....VDVMDGRFVPNITIGPLIVDAIRPLTKKVEDFAKAGADIISVHVEHNALCQIRELGKKAGAVLNPSTPL---DFLEYVLPVCDLILIMSVGFGGQSFIPEVLPKIRALRQMCDERGLDPWIEVD-GGLKPNNTWQVLEAGANAIVSAVF........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 200
9 -5.090PF17825.1; G1PD96_MYOLU/1-1455; Family of unknown function (DUF5587 topsan)  ali follow..  7  1MTDSSI--LDQEFHEKKTVTGMMTQINCEFEEIVPSSNPNSPIEVD-------HTQKDYTEVFTPISCSEKCPAFQAQNQDLFFDDEEIIFTNNL-YK-SYLPTLDTLSRLKLFL---------------------KDPLLDIKEQIFTDADFFRECFSFQGDLKDLMKEDFYVDKENFCQEKLEDTVGLNEAIPSVFSECELIAPNLDQEVGIPSPSELKESLHLVPEIITYEDENEYEKLFKRDPTTKHAIDTEDIKCSSTEILAIPSQCKPEHHKPEELEEELE---MPLPPLHLANQQSSVNSLCTGLQTFP-----SSPACKISLLTAEKSANEDCTVWQSESCRSFQNSLLLPSIEEESLAVTPVSPEWWKQAGLNLRVTETLEHLTTYFSDQDLPSDDTKLEVFLPTKVPELESWLDHKSCSSPIVLMNEESTSDNLLLQQKSPSPAEVPDLCFSDEYSSVHSPTKEEKPKDDQELVSSIIQNNENKDCLELDCTELSTESASSSKIEKASFKCSKRRENHLDLLSDFIMMRNKHKTCTSTTEVTDSDEKNEFQDKEEHSLTLQEESPIVYTNKTIEKINQEREADNVIEIQASDSQCHAYCLLEAAATPILKELGCLSWKFATVLFDQTRFLLKEQ---EKVVSDAIHQGTNAERETTFRHAGL--------LLVTIRDVLLTCSLDTAL----------------------------GYLSNAKDVYKSILG-SYLDDIWRQLEIVQFIREKMPETNYKIQELQCQILN........................... 742
10 -5.020PF09899.9; V4J3D1_9GAMM/276-1132; Putative amidoligase enzyme (DUF2126 topsan)  ali follow..  12  430....................EVNVHPASSWDDLVRSILYEEARLTRLGTEKFMLDGRHTGTGGGGPTPADSPLLRRPDLIQSLITYWQHHPSLSYLFSGTFIGPTSSLYELAIAFQQMPKGQIRNLLVDVTGNTHRTE---------FCIDKLYSP--VEFRAFEMPPHARMSLAQMLLLRALVAQQPYAHEPVRWGTELHDRFLLPHFVRQDFGDVICDLFESAWFEPFFEFRFPHYGDLITGNGIRMELRGAIEEEVTAQGTSRFVDSSVERMQVKVNGMTGARHALTCNGRRVPLHPTGRRGEFVFKAWNPPSHPTIASHNPLVFDVVDL-SHPGGRA................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 810
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 6 7   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Harder T, Kolodny R, Sitbon E, Li Z, Godzik A. Using an alignment of fragment strings for comparing protein structures. Bioinformatics. 2007 Jan 15;23(2):e219-24.