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Query: [T] KOG2290 Rhomboid family proteins, from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSEARRDSTSSLQRKKPPWLKLDIPSAVPLTAEEPSFLQPLRRQAFLRSVSMPAETAHISSPHHELRRPVLQRQTSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRVADDTAEGLSAPHTPVTPGAASLCSFSSSRSGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRARRRSFTPASFLEEDTTDFPDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKAPEQADLTGGALDRSELERSHLMLPLERGWRKQKEGAAAPQPKVRLRQEVVSTAGPRRGQRIAVPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFIRSAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPIHPSAPELAGHKRQFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGKFDLYRKRCQIIIFQVVFLGLLAGLVVLFYVYPVRCEWCEFLTCIPFTDKFCEKYELDAQLHLast
1 -49.500PF01694.22; O83947_TREPA/47-200; Rhomboid family  ali follow..  17  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VRYHRMYWQIFTYQFVHSGVWHLLFNMLGLVFFGQTIEKKMGSSEMLLFYLLVGTLCGAGACAARLNVLLLGASGSIFAILFLFSVMFIYLWGVIPIPAPLLIVGYILFEIFDLFFSRDNVSHLTHLLGVLFAWGYIRIR..................................................................... 149
2 -46.400PF12595.8; RHDF1_MOUSE/91-308; Rhomboid serine protease  ali follow..  93  1..........................................................................................VSKDSDSTQKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRMADDTADGLSAPHTPVTPGAASLCSFSSSRSGFNRLPRRRKRESVAKMSFRAAAALVKGRSIRDGTLRRGQRRSFTPASFLEEDMVDFPDELDTSFFAREGVLHEEMSTYPDEVFESPSEAALKDWEKAPDQADLTGGALDR................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 218
3 -29.600PF08551.10; RBL19_ARATH/44-142; Eukaryotic integral membrane protein (DUF1751 topsan)  ali follow..  15  7...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FAWNLITSGYFELSVYGVVFSTVSLLFMGKFLEPVWGSTEFLKFIFVVNFLTYLCVFVTA-YMPFAGFHGVLAGLLVGI............................................................................................................................. 97
4 -12.300PF04955.12; G1UBD3_METCA/11-187; HupE / UreJ protein  ali follow..  12  5...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LSPVALAHSGFSHPFFHLLAMIAVGLWAVTVAPRRVWLLAFMAVMDLGGWLGTAGIP-ETGIAASVVLLGLLVAG-----------KVRLSQFTALSLVGLFALFHGH-TEISADAERWTYAAGFITATGLLHLVGVILGGWLLPKPAWYRGCGAAMGAMGLAL.................................... 177
5 -11.900PF14325.6; R4LBF9_9ACTN/18-142; Domain of unknown function (DUF4383 topsan)  ali follow..  19  5..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LAVGLVFLLVGILGFVPGVTSSFAGHHSGAKLLGVFEVSIVHLLFGIAGLALARTAANARLFLIGGGAIYLVLWLY----------------------LVIHQDSAANFVPTADNWLHFALGIGMIGLGLA...................................................................... 125
6 -11.600PF02632.14; D1YVH9_METPS/34-176; BioY family  ali follow..  17  4..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VPITLQTFFVILSGGALGAYFGALSM-VVYLLLGFMG-VFARGQSGLGVLAGPTGGLVGVLCAIVTGLIVKMRKNPGLLWYVLAMAAGTLAIYACGLA-IIGVLAFVPGDIIKIIIAAFVARKLN................................................................ 143
7 -11.200PF07456.11; Q3XX87_ENTFC/13-159; Heptaprenyl diphosphate synthase component I  ali follow..  17  25.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AKLGLANLIT-IVAIFTMKKRDSFLLLWLRLFLTTLLGGMSGALLSYFGMLLVKQLGPKR--VSIIGISAAGGFMH------NVGQLLMASFIAQSWTVMLYLPVLSVLGILSGIAIGIAANYL...................................................................... 147
8 -10.500PF01569.21; A7EIU4_SCLS1/134-294; PAP2 superfamily  ali follow..  14  1........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AVIGLLYSLITAAVFQVFLKWLIGGLRMYDRTICTGDEDEIDDSSFPSGHSTAAFAGFVF--LSLYLNAKLKVWSNYHPAMWKLIVTYAPILGATLIAGALTIDEYHNWYDCLAGAIIGTVMA.................................................................... 149
9 -10.300PF04511.15; DERL1_CAEEL/10-202; Der1-like family  ali follow..  11  1.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IPIVTRYWFLASTIIPLLGRFGFINVQW-------FLQWDLVVNKFQFWRPLTALIYYPVTFHWLMMCYFLYNYSKALESETYRGRYLFMLIFNWFFCSGLCMAL-----------DIYFLLEPMVISVLYVWCQVNKDTIVSFWFGMRFWVLWGFNAVLRGGGTNELVGILVGHAYFFV...................................................................... 176
10 -10.200PF04240.12; B8HY64_CYAP4/54-272; Carotenoid biosynthesis protein  ali follow..  12  9...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GAATVALHGGLGKLLGFMAPAILISLSSE-LLG-TSTGFPFGHYAYLNGLGYKIAGLVPFTIPLSWFYMGLSTFLLAVTFASRWSRRVFVSILLGAILLTAWDFVLGAFFGMPYRNLLGWTGTGALFMAVASLFWSGPIELDRDQLKLPLGIYLVNFGFGAAITLVTLDQRFWIP----LGIIP................ 219
11 -10.200PF06541.11; E3GF10_EUBLK/32-189; Putative ABC-transporter type IV  ali follow..  14  2......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IFMIGCFLGTILEMIFCFVTLIYGPFNPVYGFGAVVLTIVLRPLAHKRDLIIFLFSMVIGSGFEYLCSAFDYSNLPLNIGGRTLGLLWVKDIYPYFSKWIEKIPNKVGIVLTWVLVVFMIFNMAISA.................................. 158
12 -10.200PF13886.6; U7Q2T1_SPOS1/25-230; Domain of unknown function (DUF4203 topsan)  ali follow..  12  23.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LHTFFSTAYLASLGTTVLVIYVMSPPISNAIQGAYLVAAVCTGLILGGIAIVF--KEITEGFGCLLGGFCFSMWLLCVRQGGLLQSLSGIIIFIVAFTIGAYAFYFSHWTRQYALMACIFGGTVMGIDTFSRAGLKEFWAYTKGIRVELAATILLFLAGVVSQ................................... 205
13 -10.100PF07613.11; B2A5Z7_NATTJ/13-185; Protein of unknown function (DUF1576 topsan)  ali follow..  20  18..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VLITDYFVVGGLGAAMVNA------------LVGLIGILLTKVSKVVKGPIIAAIFT----MAG---SFLGFLGVYLYSLTQKEGLNN----------YILNALFGTALAPLVSSISIIGGVIAGFIPPLAGHLLATHQGLNLYNIGFTAGFIGTLFTGIF........................................ 172
14 -9.760PF17647.1; A0A0W1R5U5_9EURY/6-120; Family of unknown function (DUF5518 topsan)  ali follow..  15  1.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................WRA------------VAVGFVVTLIIGLISGYTIPFTDMVIPVIGWGLTGFVGGAAAGYMAGHGISNGAVNGILATTIILVLGFFAVLGTVLFGVVGLSVFLGSFLVLGLYA-----GAVGGAVGALL.......................................................................... 115
15 -9.750PF13367.6; D9SZH0_MICAI/68-270; PrsW family intramembrane metalloprotease  ali follow..  12  1...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EPLKYLIFCFAWGAFVSTAISLLTAVLVAPFIEELTKAAGPLLVLIFR--FSGITDGLVYCGLSAVG-----FAMVENILYLGGHGYRAGADEYGPATGAQQVIAIFIVRILLF----FAHLFTSMTGVGLGVAAR------TADRRVRVLAPLAGLLLAMIL......................................... 169
16 -9.740PF10067.9; D0J3P9_COMT2/7-129; Predicted membrane protein (DUF2306 topsan)  ali follow..  11  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IAFHCAIAATLTGAIALWA-LPWVHRIAGR-----GFVLLMLATAISALFIRDFKLPNWAGFTPIHLLIPVTLGGLAHRRIAQHRSVMRKLYFGSCVVAGLFTLLP--------GRLLGNLL.......................................................................... 123
17 -9.650PF06496.11; V5SI92_9RHIZ/8-165; Protein of unknown function (DUF1097 topsan)  ali follow..  16  2.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VSIGLLGGVATYLFLSPFGFGLQIWAAFIAWASFYHAGGGTSGFTSSVL------ANLWGVLWGAITLIAITQTGYGSTLGLP---LWAAICVAIGVALMILGAKISPFSAIPAQVYGFASTVAFTLLTNTAFALTRPDLSNPAIVIASSMVVGAVF..................................... 149
18 -9.600PF06177.11; R6CV72_9CLOT/9-154; QueT transporter  ali follow..  10  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LVQAAMIAA--LYVVLTLLANLASGAIQIRLSEMLSVLPFFTPAAIPGLFVGCMLSNFITGACLLDIVLGSFATLIGAVGAYLNKWLVPIPNIVSNTIIVPLVLMFGYHLEDAFWYLALTVGIGEIISGGVFGMILLFTLKK.......................................................... 146
19 -9.550PF03772.16; Q2SIN8_HAHCH/227-491; Competence protein  ali follow..  15  13................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QWDVLRRSGLTHLLV------ISGLHIGLIAMLVMFTLRWMFC-IACGLTILTILSYVALIDYGLPA--LRASLAVSFALLMLRLRRRILPSTFFIAVLSCSLLLDPLAPWS------GFWLSFVAVGLLFAAFSHRPLQSFSKWGALWRSQMVLTIGLAGFLAISFQQIPSSAPLANLIATPLIT............. 193
20 -9.530PF10101.9; B2U841_RALPJ/177-938; Predicted membrane protein (DUF2339 topsan)  ali follow..  17  3..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NSVVRVGILVLFFGVAFLLKYAADNSLLPVEFRLAGVAVG-AIVLLGIGWRLREKRPGYALVGGGVGVLYLTVFAATRVVPLLSPG-MAFPLLVLICALAAGLAVAPALAFTGSAGGFLAPILISYALLNAGIFAIAWFRAWRALNLLGFVFTFGIATAWGVLRYQPSLLASTEPFLILF................. 197
21 -9.390PF07694.12; Q9KU35_VIBCH/25-193; 5TMR of 5TMR-LYT  ali follow..  9  16..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KISVYVLF--SLFCIM------TYFGLQINDAIANTRAIGAVMGGLFGG-AVGLTGGLHRYTLGGFTDLACAISTTAEGLIGGLLHTYLLRKGKGKLLFSPSIVFAVTLF------------IVQMLIILVVAKPFEQSYALVSTIAAPMIIANSVGAALFMSILLD.................................. 169
22 -9.350PF13491.6; C1DB46_LARHH/22-198; 4TM region of DNA translocase FtsK/SpoIIIE  ali follow..  12  1..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ANLLQEAWWLVMVAAAVYFVLILASYSPADPSWSHSIGGHP---IGNWGGTLGAYLSDMLL----LFGLSAWWLVVFCGAIVLWGYRNIRRVSPALDKVTAIASTGFVMILVASSGFEAILAPGGLL-GRFVGLGLQQFIGF---------ATMLLLLVWAIGISLFTGLSWLD............................... 171
23 -9.110PF01001.19; POLG_HCVH/1728-1921; Hepatitis C virus non-structural protein NS4b  ali follow..  12  40..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NFISGIQYLAGLSTLPGN--AIASLMAFTAAVTSPLTTGQTLLFNILGGWVAAQLAAPGAATAFVGAGLAGALGKVLVDILAGYGAGVA--------GALVAFKIMSGEVPSTEDLVNLGALAVGVVFASIL..................................................................... 175
24 -9.040PF17076.5; SBE22_CANGA/1-813; SBE2, cell-wall formation  ali follow..  7  31.SRKESGMRSRTSSGSAQAVGLGLGRRPSDNLFHGHADPLDTMQMLSEALPQPPKIEHGMRRERPISNDSIMTTKSSEIFSTSSSDT--SVATNDSEDHSFGMDKSVDNSSTNATLTNRSIENRSNGDSYSIGEKSDVSVNRSTKSGNNPLQRTQSETISVNMSHNRSMNGAMKQPTPPFMGKNSSIPNLRYNSQPQQDNRSVPNGEFGSKLYNLSNSTSAIIPNAGTGSKLALTPSQRYRLRKEQSEHALRDVIKRKEKLYDEQDGIIELQEGDIDGSFIFNVPMSSYSTTSFLNTTRQKDSATNSSSTITERITPGENQSQNNRESNMSFASTISSTSMLDFFEMPTSPIPGVNKVSDFQYLQDTTKH-----LSSVYLHSSTKLSKSKLSERTASAD----------------------------PLEFKEASEKGMEDLLLVSENKLDAVSHTRPWLPPKDPE-----------KLHEREISKTLSMASLDQLEK.................................................................................................................................................................................................................................................................................................................................................................... 491
25 -9.030PF14089.6; N0AV75_9BACI/12-190; KinB-signalling pathway activation in sporulation  ali follow..  15  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GAVTTGIVGFIVRWGEFAHFFTDYEVGEIISIMFWLMGIGLIFSVL------------SQMGFFAYLTVHRFALGIFRSATLWNRVQIVLIALVLFDLVYFRYSFFAKKGESFIPYVVVALFIFVFGLIIAWQKAKQTSKDAFVSALFFMVVITVLEWMPTLRVNEKSWLYLMLIPLL--VCNAYQL-LILH 177
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;