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Query: [E] KOG2380 Prephenate dehydrogenase (NADP+), from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAETLITKPPLSLSFTSLSSMLPSLSLSTANRHLSVTDTIPLPNSNSNATPPLRIAIIGFGNYGQFLAETLISQGHILFAHSRSDHSSAARRLGVSYFTDLHDLCERHPDVVLLCTSILSIENILKTLPFQRLRRNTLFVDVLSVKEFAKTLLLQYLPEDFDILCTHPMFGPQSVSSNHGWRGLRFVYDKVRIGEERLRVSRCESFLEIFVREGCEMVEMSVTDHDKFAAESQFITHTLGRLLGMLKLISTPINTKGYEALLDLAENICGDSFDLYYGLFVYNNNSLEVLERIDLAFEALRKELFSRLHGVVRKQSFEGEAKKVHVFPNCGENDASLDMMRSEDVVVKYEYNSQVSGSVNDGSRLKIGIVGFGNFGQFLGKTMVKQGHTVLAYSRSDYTDEAAKLGVSYFSDLDDLFEEHPEVIILCTSILSTEKVLESLPFQRLKRSTLFVDVLSVKEFPRNLFLQTLPQDFDILCTHPMFGPESGKNGWNNLAFVFDKVRIGMDDRRKSRCNSFLDIFAREGCRMVEMSCAEHDWHAAGSQFITHTVGRLLEKLSLESTPIDTKGYETLLKLVENTAGDSFDLYYGLFLYNPNAMEQLERFHVAFESLKTQLFGRLHSQHSHELAKSSSPKTTKLLTSLast
1 -53.900PF02153.17; TYRA_BACSU/20-279; Prephenate dehydrogenase  ali follow..  17  1..........................................................................................................................................................................................................................................................................................................................................................................................IALAIKKNHKRIIGIDISDEQVAALKLGVIDDRADSISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGSTKQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPKTDKQAVEQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHLYPLVKRFAAGGFRDITRIASSSPAMWRDILLHNKDILDRFDEWIREIDKIRTYVEQEDAENLFRYFKT............ 260
2 -19.600PF10727.9; Q743Y6_MYCPA/8-128; Rossmann-like domain  ali follow..  15  1................................................RPARLKVGIISAGRVGTALGVALERADHVVCSAISHASRQRAQRRLPDTPVATPPEVAAGAELLLLAVPDSELAGLVSGLAAEAVRAGTIVAHTSGANG--VGILAPLTRQGCIPLAIHP........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 121
3 -18.100PF03446.15; Q8FTI1_COREF/15-184; NAD binding domain of 6-phosphogluconate dehydrogenase  ali follow..  13  1.............................................................................................................................................................................................................................................................................................................................................................................QIGVVGLAVMGSNLARNFARNGHTVAVYNRSTDKTDATDGNFIPTKTVEDFVAALEKPRRAIVMVQAGAATDAVINADAMEEGDIIIDGGNALYTDTVCREKEMARGRHFVGA-GISGGEEGALNGPS----------IMPGGPKESWEALGPLLESIAAKVDGVPCVTH......................................................................................................... 168
4 -17.300PF07991.12; ILVC_METAC/15-178; Acetohydroxy acid isomeroreductase, NADPH-binding domain  ali follow..  13  2..................................................KDKTIAIMGYGSQGHAHARNLHESGLNVVVGLRKGSSSWAKAESDGLKVMTVEEAAKAADVIMILLPDEKQASVYYSQIEPSLEAGNAIHYNQIVPPKDVDVFMVAPKGPGHIVRRTYTEGIGVPGLIAVYQD--------------ATGKARDLALAYAKGIGA......................................................................................................................................................................................................................................................................................................................................................................................................................................... 160
5 -15.200PF01210.23; GPDA_COXBU/7-162; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus  ali follow..  13  1.....................................................PIAILGAGSWGTALALVLARKGQKVRLWSYESDHVDEMQAE-LKAYCDLKASLEGVTDILIVVPSFAFHEVITRMK-PLIDAKTRIAWGTKGLAKGSRLLHEVVATELGQVPMAVISGPSLA................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 135
6 -14.800PF03807.17; Q21544_CAEEL/2-98; NADP oxidoreductase coenzyme F420-dependent  ali follow..  21  1.....................................................KIGFIGAGKMAQALARGLINSGRIASSPKRDEVFLDQCKALGLNTTHDNAEVVQKSDVVFLAVKPVHVSKVASEIA-PALSKEHLVVSIAL................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 96
7 -14.600PF00670.21; SAHH_DICDI/191-351; S-adenosyl-L-homocysteine hydrolase, NAD binding domain  ali follow..  11  24............................................................................................................................................................................................................................................................................................................................................................................KVAVVAGYGDVGKGCAQSLSKMGARVLVTEIDPINALQACMDGYQIVTMETAAPLSNIFVTTTGC----RDIVRGEHFAVMKEDAIVCNIGH........................................................................................................................................................................................ 111
8 -12.500PF02558.16; Q9K9R6_BACHD/6-154; Ketopantoate reductase PanE/ApbA  ali follow..  17  1......................................................VAVIGSGSIGLLLYAYLKLANWPALLVTNPEQADHLNKEGLVTATPLSSFSAEEAEVGFITVKSFAVKALLPQLQ--RKKWDGLVF.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 98
9 -12.100PF03721.14; UGDH_CAEEL/10-205; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain  ali follow..  12  1............................................................................................................................................................................................................................................................................................................................................................................SKVVCVGAGYVGGPTCAMIAHKCPTVTVVDMNTAKIAEWNSDKLFFSSDIPKAIAEADLIFISVNLKYVESVSRTIA-QYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENLKFSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVR....................................................................................................................... 195
10 -11.700PF02737.18; Q2YR99_BRUA2/5-183; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain  ali follow..  10  1.....................................................TVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPQEEQRADAMKLIRPANSMEDLAGVDLAIEAADETIKRKIFAQLC-PVLNPEAILA--TNTSSISITRLASTTDRPERFIGIH-FMNP-----------VPVMKLVELVRGIATEEDTFRKSNDFVTALGKTVTVAE................................................................................................................................................................................................................................................................................................................................................................................................................................... 178
11 -11.500PF02826.19; Q98GE4_RHILO/107-283; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain  ali follow..  22  39............................................................................................................................................................................................................................................................................................................................................................................KTIGIVGLGAVGQAVGHAAHGFDLKVVATTRSMQPAPEKVGFLS------DALVEQSDIIVLCCPLTETRGLISRERIARMKPNALLINVSRGPVVDDDALIEALREGLDVFSTQPL----------YNHPYFGFDNVIITP...................................................................................................................................... 174
12 -11.100PF02254.18; Q92CZ9_LISMO/5-120; TrkA-N domain  ali follow..  16  1..............................................................................................................................................................................................................................................................................................................................................................................FAVIGLGRFGGSICRSLVEQGMEVLAIDSDEERVNAVIANSTDENALRQLGIRNFEHVIVAIGEDIQSSILTTLILKEMGVKYVTA----------KATNDKHAKLLDKIGADRVVHP............................................................................................................................................................ 116
13 -10.900PF00056.23; MDH_CHLAA/3-142; lactate/malate dehydrogenase, NAD binding domain  ali follow..  13  1....................................................KKISIIGAGFVGSTTAHWLAAKE-DIVLLDFVEGVPQGKALDLYEASPIEGADTANSDVIVVTSGAPR---------KPGMSREDLIKVNADITRACISQAAPLSPNAVIIMVNNPL....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 120
14 -10.700PF10100.9; H6NF63_9BACL/6-429; Staphylopine dehydrogenase  ali follow..  13  2.....................................................RVLILGTGPASVQLAVTLKNKWNCIGIAGRESVRAMQGECIVDHVFQGYGTITGEWDTLILAVTTDAYVAVLKQIHGELLKRVRCMLLLSP-SNRLVRHYMNGIQSSAEIISFSTYSCATRWAGPRPSHQVITVKKKVFIGSTHGRSPAIESLCGLYEKLGTTLEVMD----EAESRNISLYVH--PLFMNEISLGAVFGEDVTQKYVYKMFPE----TQYLIRDMLAAWKEMMSILEQLHFEGINLLKFMTDDNYPVRLESLSRH................................................................................................................................................................................................................................................................................................................................. 294
15 -10.600PF01118.24; DHAS_YEAST/6-132; Semialdehyde dehydrogenase, NAD binding domain  ali follow..  13  2......................................................AGVLGAGSVGQRFILLLANHPHFELKVLGASSRSAGKKYVDAIVSECKSEFFKECDIVFSGLD----ADYAGAIEKEFMEAGIAIVSNAKREQDVPLIVPVVNPEHLDIV............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 127
16 -10.100PF01225.25; MURC_RHOPA/9-108; Mur ligase family, catalytic domain  ali follow..  20  2......................................................IHFVGIGGIGSGIAEVLCNLGYTVQGSDASESVNRLREKGIQIHVGHQADNIKGADVLVVSTAIKRDNPELRAQRIPVVRRAEMLAELMRLKS............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 100
17 -9.930PF13380.6; B9JVC9_AGRVS/19-138; CoA binding domain  ali follow..  8  1....................................................KIIALTGASRPSHGVMHFLLNHGYRVIPVNPGQAGKDILRQTV----ASLGDIPEPVDMIDVFRASEYLPAVVDEALGLKHLPKVIWAQLGVRDDQAAARAEA---AGIKVVMEYP........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 120
18 -9.790PF01262.21; Q9S227_STRCO/141-353; Alanine dehydrogenase/PNT, C-terminal domain  ali follow..  10  21............................................GGVPGVLAGRAVVIGGGVSGWNAAQIAIGLGFHVTLLDKDITKLREADK-VVSNAFELEKACLEADLVIGAVPGAKAPKLVTNELVSRMKPGSVLVDIAIDQGGCFEDSHPFPVHNSVFYCVANMPGAVPNTSTYALTN-----------------ATLPYIVELADRGWAEALRRDPALAKGLNTHDGKVVY................................................................................................................................................................................................................................................................................................................................................................................................................... 212
19 -9.490PF00389.30; Q9KCG9_BACHD/20-325; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain  ali follow..  16  135............................................................................................................................................................................................................................................................................................................................................................................KTLGIIGFGRIGSQIAKRAKAFEMTPYVFDPFLTKARAEKLGVTVAS---DDVLQVADIITVHTPLTETKGLLGMKNIGKTKKGVFLINCARGGIIDEEALKHYLREGLDVFEEEPV----------ADEELLAFDNVIATPHIAASTKEAQLNVAEQVSQEVLHF.............................................................................................................. 295
20 -9.100PF05221.17; D9SB20_FIBSS/15-498; S-adenosyl-L-homocysteine hydrolase  ali follow..  11  4............................................................................................................................IKDINLAIEGRKEL--DLAETEMPGLMALRKEYAGK------KPLAGARIMGSLH--------------------TVQTAILIETLVDLGADVRWVSCSTQDNAAAAVV--VGKNGSVSNPQGVPVFAWKGESLEEYWENTARALGKTADLIVDFLATCRKIFEKDPKQWTRAREALKGVSEETTTGVHRLYQMAQAKRLKFPAINVNDSVTKSKFDNLYGCRHSLIDGINRATDVMMAGKIAVVCGYGDVGKGCAQSLRGQGARVIITEIDPCALQAAMEG--YEVKTLDEVVSYADIFVTTT---GNTGIISAAQMEKMKNRAIVGNIGHFDNEIYDEWIFADGHSILVLAGRLLNLGCATGHPSFVMSASFTNQTIAQIDLWLNAQGKDTVAGIKYESGVVYTLPKILDEKVARL-HLEKL-GVHLTRLTQAQADYIGVPVEGPYK................................................................... 479
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;