current user: public
If you have questions about the server, please let us know.

Query: [E] KOG3124 Pyrroline-5-carboxylate reductase, from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320
# Score Template Links and tools%idFirst MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETVKHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRCMTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAYAFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTLTPSSPGKLLTRSLALGGKKDLast
1 -56.000PF14748.6; Q62T44_BACLD/162-265; Pyrroline-5-carboxylate reductase dimerisation  ali follow..  34  1...................................................................................................................................................................ESALDAVTAVAGSGPAFVYRFVEALQASAAELGLPEKTAKQLIIDMMAGAAQML-ETGRDPSVMRKEITSAGGTTEAGLRMLDDHQFEQTVISCVKEAANRSAEL.................................................... 104
2 -41.700PF03807.17; Q21544_CAEEL/2-98; NADP oxidoreductase coenzyme F420-dependent  ali follow..  44  1.KIGFIGAGKMAQALARGLINSGRITADNIIASSPKRDEVFLDQCKALGLNTTHDNAEVVQKSDVVFLAVKPVHVSKVASEIAPALSKEHLVVSIALG.............................................................................................................................................................................................................................. 97
3 -14.700PF10727.9; Q743Y6_MYCPA/8-128; Rossmann-like domain  ali follow..  21  5LKVGIISAGRVGTALGVALERADH----VVVACSAISHASRQRAQRRLPDTPVATPPEVAAGAELLLLAVPDSELAGLVSGLAATVRAGTIVAHTSGANGVGILAP...................................................................................................................................................................................................................... 108
4 -13.000PF01210.23; GPDA_COXBU/7-162; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus  ali follow..  10  1.PIAILGAGSWGTALALVLARKG--DHVDEMQAEGVNNRYLPNYPFPETLKAYCDLKASLEGVTDILIVVPSFAFHEVITRMKPLIDAKTRIAWGTKGLAKGSLHEVVATELGQVPMAVISPSLATEVAANL............................................................................................................................................................................................ 142
5 -11.500PF07991.12; ILVC_METAC/15-178; Acetohydroxy acid isomeroreductase, NADPH-binding domain  ali follow..  12  4KTIAIMGYGSQGHAHARNLHESGL----NVVVGLRKGSSSWAKAES--DGLKVMTVEEAAKAADVIMILLPDEKQASVYYSQIEPSLEAGNALVFAHGFNIHYNQIVPPKDVDVFMVAHIVRRTYTEGIGVPGLIAVYQDATGKARDLALAYAKGIG................................................................................................................................................................... 159
6 -10.800PF10100.9; H6NF63_9BACL/6-429; Staphylopine dehydrogenase  ali follow..  13  2.RVLILGTGPASVQLAVTLKNKWNCC--GIAGRESVRSEPFFTALDESGRHVFQGYGTITGEWDTLILAVTTDAYVAVLKQIHGELLKRVRCMLLLSP-SNRLVRHYMNGIQSSAEIISFSSHQVITTAVKKKVFIGSTHGRSPAIESLCGLYEKLGTTLEVMDSPME--AESRNISLYV------------------------------------------HPPLF-GAVFGEDVTQKYVYKMFPEGPITQYLIRDMLAAWKEMMSILEQLHFEGIN.......................................... 274
7 -9.680PF02558.16; Q9K9R6_BACHD/6-154; Ketopantoate reductase PanE/ApbA  ali follow..  16  1..VAVIGSGSIGLLLYAYLKLANHLNKEGLTFVAKSGEHQPIS------VTATPLSSFSAEEAEVGFITVKSFAVKALLPQLQRK--KWDGLVFFQNGMTHLEILRQIPARAICCGIVRESDVRVQHTGDGAIWI......................................................................................................................................................................................... 144
8 -9.680PF03446.15; Q8FTI1_COREF/15-184; NAD binding domain of 6-phosphogluconate dehydrogenase  ali follow..  10  1.QIGVVGLAVMGSNLARNFARNGH----TVAVYNRSTDKTDKLISTDGNFIPTKTVEDFVAALEAIVMVQAGAATDAVINQLADAMEEGDIIIDGGNALYTDTVCREKEMAARGRHFVGAISGGEEGALNGPSIMPGG---PKESWEALGPLLESIAA.................................................................................................................................................................. 158
9 -9.580PF02153.17; TYRA_BACSU/20-279; Prephenate dehydrogenase  ali follow..  10  13............................RIIGIDISDEQAVAALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGSTKQKVVDYADQVLPSRYQFVGGHPAKEFLFENAFYILTPGQKTDKQAVEQLKNLLKGTNHFVEMSPEEHDGVTSVISHFP---HIVAASLVHQTHHSENLYPLVKRFAAG---GFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIRE........................................................................ 238
10 -7.570PF01408.22; YEAH_SCHPO/36-187; Oxidoreductase family, NAD-binding Rossmann fold  ali follow..  9  1FKCAIFGCGGINFGTAEGPLELVLGHRLQVVALLSPHKSSHERVLKQKATREFYSADEYLEYLDAYIIGIPPETHGSTQKGADLELA----ILKRFPDASLFIEKPISAAPVEDAFAVARRLPSESVISVG............................................................................................................................................................................................. 151
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 4 1   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.