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Query: [R] KOG3518 Putative guanine nucleotide exchange factor, from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MCAAQAHQHCSTSVAGDRLLGSSTELAPSLLGIYDTLTNSFAAGGVAAAPTATSHESKASSSGDSTPKRSNSNCSSSSSTGSSTGSCSSVPTSDDQSASYTLASSSTHLGHQEPPAPLVVAGLRDEPDGAQLSRLVQRRSQESQIHGSSSSIASSGSSRRGSNIRILSPNVHRIITHSDIQPVEAVSAEALKQHQQQSQRSPTQGRYIKTGHSGTPPAAGSAPKLKLSHIPLSKITGKLSTQSGSELVSTFDSSNEYLNSVAFAAFEKSKPQDEDRTPTNKSVPGTPFHFDGHPFQGRKLTLPRYDSQQSIKLIEMEQLAATSAQLLHAKPATPGTPATPTPSATKAKEFVCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEGECFPLGLast
1 -35.800PF00621.20; Q54DW4_DICDI/1134-1313; RhoGEF domain  ali follow..  16  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LAQELALSEEEYVDSLTYIYNVFLQPIKKSIDVSYQENLEISSNFETLFSCHKTFLIALKERIAEKPLMSDIFMEKAGFLKLYNYYVQNHTRSLQVLEHCIEYPLFAIHLKRIESD--QNTELKVLLAQPLRRVSKYYLVLREILQYTDYDALNRVVANLKDQTDKFN........................................................................................................................................................ 180
2 -15.500PF15411.6; G9NQW5_HYPAI/397-517; Pleckstrin homology domain  ali follow..  17  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ESFGKLLLHGVYGVITGKDYEIYLFECILLCCKEISPAKLQLKGRIFMTNVDVVSLSKPGSHSVQIWWKGDPGENFTIKFLTEEMMKKWANG................................. 121
3 -13.000PF16652.5; C3ZLK0_BRAFL/964-1114; Pleckstrin homology domain  ali follow..  11  2.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NCDGLPEQLIFNSLTNCLGPRKFLHSGTLFKVKSKELQAFLFNDFLLLTTCSKSVSGMYRQPIFLNEVIVKLPTDKEDADEPVFFLNHVDKVYQFRTEKASERNQWMKIMESASQQYIETERKKREKAHQARMLRST..... 151
4 -12.400PF15405.6; G1XBW2_ARTOA/827-954; Pleckstrin homology domain  ali follow..  18  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LIFKGSLKRSPT---TGTGDIQAFLFDHAILLVKIKVVNKKVYKRPIPLELLVINEMAEVLPERITFQHLGKRGYVLSLFAATVVGRRKWMEHIEA.............................. 126
5 -12.100PF16453.5; E4XUI6_OIKDI/553-682; PH domain  ali follow..  20  5.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LALPFRRLVCYCRMYQ------------------------VADVTRPQR----------------------------------PGLHTREVFLFNDLLLVTKVKRRSQYTYRLDAPLTSLEVEY-FGNEHYPHAVRIIKTGKVLITFSLPNQDDCKNFIQDISESILEVRQMESLRIEESLE............ 129
6 -11.700PF17838.1; H2UDE2_TAKRU/444-559; PH domain  ali follow..  20  4.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GGLFKSAELLRR-KLLHDGNLLWKRHKDVQVLLMTDVLVFLQEKDQRYLDKPAVLSLQNLIVRD-IANQERGMFLIIDSSPPVMYEFHATTKEKKNVWMRHIQHAV............................ 115
7 -7.700PF15818.5; G3T452_LOXAF/26-1066; Coiled-coil domain-containing protein 73 family  ali follow..  16  12...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ALEEL-EAETQYEEHIGKIIETQ--ELKWQKETLQNQKETL--HEEAMAVFKKQLMCALE--------------EEKGKYQLAT---EIKEKEIEGLKE----------------------------LKALQ-VSKYSL--KKL------SEMEQKVQL---------HFLAKEDHHKQLNEIEKY------AIITGQFGLVKENHEKLERNVQEAIQLNKRLSALNKKQEFELCSLKKELKKVTSDLI--------KSKVTCQYKMGE----ENTNLTIKERKFQELQERLNMELELNKKINEEISRIQEEKQN..... 254
8 -6.800PF15413.6; A0A0D2UEA3_CAPO3/130-226; Pleckstrin homology domain  ali follow..  13  2........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HGWLNKLGAKGLVKTWKTRWMVFQPQLHYYESPKDVY---LGTIDISNATFTANKHSDSGHFSI---NTEARRYILAARDKETMLGWLGSLQE.............................. 96
9 -6.760PF15406.6; H6BUU9_EXODN/90-198; Pleckstrin homology domain  ali follow..  10  36.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TAAWARETGKGLLFFAKRVEDKASPVGIINLADASNVI--KDGYDQFSF---KAGGHQHRFEASKPTERDGWVVAIEKA............................. 109
10 -6.520PF08336.11; B5DQ23_DROPS/33-164; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region  ali follow..  15  5....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LLNLFELEREFMDNF----IVYADVLQE-------KVDNLKMYIDSLDRGTHENHKEREGFVSNPL----------NAFGLIRRLHQEWPKWQNYTKKPLGVAQLTA-MEELLSKAPEPFDMTE-SLKSMDRIERYDLPASHIAR.............................................................................................................................................................................. 127
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 2 6 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.