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Query: [S] KOG4463 Uncharacterized conserved protein, from COG1018

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSSANIVPSNMGITKFLLLTISTSSVVAGVFALKPFFHINFGLHLLSHYQYWRILLWQFIYWNSTEVFQALFIIYQARDVERLLGSHRFASFCVYMFILGMFVTPIFSFLYSLLFKNLDYIQPGPTFLIFAILYQYYYIVPSTVFVRLFNIKFTDKFQMVIPMIGLAFSHFPSTFINAFLGWTMGMFYHLSLLPGTSWRLPIRFVKPALSPTHVFIRPPYSDMQNASTFNPETLFALPTGLDAERTENENQVENPVSNADANDSPTRQNARATAIASSSNTAASFRNRQQISHPPLGRTSSSSVLPTGPASQLYDMLSGRSERPELGNIREEDINTVQTIMQTSRAQAIQALSQTNDVQRAVELLLEQTADYLast
1 -39.900PF01694.22; O83947_TREPA/47-200; Rhomboid family  ali follow..  18  1............................................VRYHRMYWQIFTYQFVHSGVWHLLFNMLGLVFFGTIEKKMGSSEMLLFYLLVGTLCGAGACAAYLCVG----RLNVLLLGASGSIFAILFLFSVMFPTALIYLWGVIPIPAPLLIVGYILFEIFSRDNVSHLTHLLGVLFAWGY........................................................................................................................................................................................ 145
2 -29.600PF04511.15; DERL1_CAEEL/10-202; Der1-like family  ali follow..  13  2..........PIVTRYWFLASTIIPLLGRFGFINVQWMFLQWDLVVNKFQFWRPLTALIYYPVTPHWLMMCYFLYYSKALESETYRGRSADYLFMLIFNWFFCSGLCMALDIYFLL---------EPMVISVLYVWCQVNKDTIVSFWFGMRFPARYLPWVLWGFNAVLRG--GGTNELVGILVGHAY........................................................................................................................................................................................ 173
3 -25.400PF08551.10; RBL19_ARATH/44-142; Eukaryotic integral membrane protein (DUF1751 topsan)  ali follow..  12  7.................................................FAWNLITSGYFELSVYGVVFSTVSLLFMKFLEPVWGSTEFLKFIFVVNFLTYLCVFVTAIALYYITRLEVYLFAGFHGVLAGLLVGIKQ.......................................................................................................................................................................................................................................... 99
4 -11.200PF14925.6; D2H5Y1_AILME/274-908; Domain of unknown function  ali follow..  8  474........................................................................................................................................................................................................................ETILSIRKNSSEKSSILSPPFSAGSPVYSYKRSHISKIQDTSLEEVSSISTSDLSSSHWTEEKENQIDRNSMHNSKVIKRGQDISIKLKTRTGCKSSEKSQSPRTSQVSSYLPSNLSELELNVL--LAEDDEFPSLNISKQCKDICELVINKLPGY 634
5 -10.800PF04487.12; Q1L8S4_DANRE/1-240; CITED  ali follow..  8  81........................................................................................................................................................................................................................GHPHQMQQANMMYASPNQQPQGHPQSQHHHMHPQNQHPQQYMGSGGLSASQQLMASMHLQKLNTPYHGHPLGPMNGHHMGNVQHRMGPAQLAGMQMGMGGPALGHNVMDIDLIDEEVLTSLVLELGLDRVQELPEL-GQNEFDFFSDFVCKQQPS. 236
6 -10.300PF10667.9; B4E8G7_BURCJ/1-248; Protein of unknown function (DUF2486 topsan)  ali follow..  7  94........................................................................................................................................................................................................................GGETDAPAEPGAAEHVVAEEAGATMAPLRSSLVNDDLPQPTFAAMAHEAAGHAPDTAMPEAVLPSAAPQPDAQAADGLTPEDAQHIAERLRNRLTNYLTGAGREAIEARCRDALHEHSAWLVGQV---TREVALALETE--VRDAVDEEIARRRA. 247
7 -10.200PF05793.12; T2FA_XENLA/2-524; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)  ali follow..  9  348........................................................................................................................................................................................................................ESETSEDSDIDGASSSLFMQKKKTPPKKDKKGGSNSSSRGNSRPGTPSPDTGNTSSTLRAAASKLEQSKRGTVSNTPAAKRLKMEAGPQNTSGKSTPQPQSGKSTPSSGDIQLTEEAVRRYLTRKPMTTKDLLKKFQSSEQTVNVLAQILKRLNP. 508
8 -9.700PF10199.9; Q7XP63_ORYSJ/211-402; Alpha and gamma adaptin binding protein p34  ali follow..  7  5...............................................................................................................................................................................LERLLGALSAHMW------------PGMILKSGNRITVPSLVEKEESTDDESNYEFEYEVLSHGSDEQWEFIGESSTSRDLEGLNEDTATHDKTNQVVDADANSVASNPLPNGRMTETAEEKLVPQSHKSEVSNDMDNTQADASEKLQAGIPEGNKDDLERLMSEIGNMRSNL-RLMPDFQRKEMAAKLAMK..... 192
9 -9.640PF10390.9; I3MZ77_ICTTR/11-291; RNA polymerase II elongation factor ELL  ali follow..  5  109..................................................................................................................................................................................................................................................QDKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYVGKRVQIRKAPQAISDAVPERKRSTPMNPANTIRKTHGSSSVSQRPYRDRVIHLLALKTYKKPELLARLQKDGKDKNSLGAILQQVANL 241
10 -9.340PF16612.5; L9KJ60_TUPCH/1188-1329; C-terminal unstructured region of RGS12  ali follow..  11  4..........................................................................................................................................................................................................................................SKRTATSNGKEKATQPGDRQEPAHDYSDSPVSSPATSTGSAHSPSGPPGTTPPGQNSPSGPFCAPLPPTPHMQEGATQIWKRQSREVEAGGIQTVEEEHVADL-------------TLIGEGDISSPNSTLLPPPS.. 126
11 -9.330PF17300.2; G8ZX91_TORDC/12-250; Filaments in between nuclei protein-1  ali follow..  6  88........................................................................................................................................................................................................................GNPKIEDSGSVTNLVFPASPTRVTFSNERKIGGDGSLSKLRSRFTNGLLSPQRGANMPKTELQGKNLFSKLENDEQINDFTTSPKRRLENLEEEAISSNKRKQIKKTVKFELPASDENENLRKQVQDLKHTLSKVIEHQNEMEVRLKLVESQ.... 239
12 -9.260PF06614.11; F7FEE8_MACMU/67-238; Neuromodulin  ali follow..  9  18........................................................................................................................................................................................................................GTTATEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA. 172
13 -9.160PF11081.8; SF33K_ADE02/1-225; Protein of unknown function (DUF2890 topsan)  ali follow..  12  50........................................................................................................................................................................................................................EVSDETPSPSVAFPSPAPQKLATVPSIATTSAPQAPPALPVRRPNRRWDTTGTRAAPTAPAAAAAAATAAVTQKQRRPDSKTLTKPKKSTAAAAAGGGALRLAPNEPVSTRELRNRIFPTLYAIFQQSRGQEQELKIKNRSLRSLTRSCLYHKSE. 204
14 -9.150PF01080.17; W4XU10_STRPU/68-474; Presenilin  ali follow..  9  12..........VPVSLCMLVVVATISTVSFYTESGDVYLIYTPFHEKSDQA--ALANALIIIGIVLIMTIFLVVLYKYRCYKVIHGWLVLSSLLLLFFFTFFYLQELLVTYFTIAVIMWNFGMVGMVSIHWPLRLQQLYLIVISALMALIFIKYLPEWTLWTILAAIAVYD--------LFAVLCGPL-----------RMLVETAQERDEQIFPALIYSSTMVWLVGMADIDSPPPKSKAKQEPPVEEHTAEENATATGTTVSGQEDQTVSSDQEVNGGFDTVFTERRERDLERSANSSVTSEDRRAAVRALRQNNGPSNRQPPVDEEEEEERGVKLLGDFIFYSVLVGKA-SASGDWTTTIACFVA..... 363
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 4 1   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.