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Query: [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases, from COG1018

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRCVVFNLREEEAPYVEKWKQSHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDEVYDYMGACKLKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREIETFVRKRDFRWQKPILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPNDAAKEWLTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVIDSQALLDSLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPHIAFYTETAIENMVFNSLDACTTVLRGEPCAAEIKLLast
1 -75.100d1j4aa1 c.2.1.4 (A:104-300) D-lactate dehydrogenase {Lactobacillus helveticus [TaxId: 1587]}  ali model 3D-neighbors follow..  37  1......................................................................................................PNAIAEHAAIQAARILRQDKAMDEKVARHDLR-WAPTIGREVRDQVVGVVGTGHIGQVFMQIMEGFGAKVITYDIFRNPEEKKGYYVDSLDDLYKQADVISLHVPDVPANVHMINDESIAKMKQDVVIVNVSRGPLVDTDAVIRGLDSGKIFGYAMDVYEGEVGIFNEDWEGKEFPDARLADLIARPNVLVTPKTAF................................ 197
2 -75.100d1sc6a1 c.2.1.4 (A:108-295) Phosphoglycerate dehydrogenase {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  29  1.....................................................................................................NTRSVAELVIGELLLLLRGVPEANAKAHRGVGN-KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALADALASKHLAGAAIDVFPTEPAT----------SDPFTSPLAEFDNVLLTPHIGG................................ 188
3 -74.500d1ygya1 c.2.1.4 (A:99-282) Phosphoglycerate dehydrogenase {Mycobacterium tuberculosis [TaxId: 1773]}  ali model 3D-neighbors follow..  32  1.....................................................................................................NIHSAAEHALALLLAASRQIPAADASLREHTWK-RSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPAAQLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPC--------------TDSPLFELAQVVVTPHLG................................. 184
4 -71.800d1mx3a1 c.2.1.4 (A:126-318) Transcription corepressor CtbP {Human (Homo sapiens), Ctbp1 [TaxId: 9606]}  ali model 3D-neighbors follow..  33  1.......................................................................................................EETADSTLCHILNLYRRATWLHQALREGTRVQSVESGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPF------------SFSQGPLKDAPNLICTPHAAW................................ 193
5 -71.000d1gdha1 c.2.1.4 (A:101-291) D-glycerate dehydrogenase {Hyphomicrobium methylovorum [TaxId: 84]}  ali model 3D-neighbors follow..  28  2......................................................................................................TVATAEIAMLLLLGSARRAGEGEKMIRTRSWP-PLELVGEKLDNKTLGIYGFGSIGQALAKRAQGFDMDIDYFDTHRASSSDEATFHDSLDSLLSVSQFFSLNAPSTPETRYFFNKATIKSLPQGAIVVNTARGDLVDNELVVAALEAGRLAYAGFDVFAGEPNI--------------NEGYYDLPNTFLFPHIGSA............................... 191
6 -70.500d2naca1 c.2.1.4 (A:148-335) Formate dehydrogenase {Pseudomonas sp., strain 101 [TaxId: 306]}  ali model 3D-neighbors follow..  24  2........................................................................................................SVAEHVVMMILSLVRNYLPSHEWARKGGWNIADCVHAYDLEAMHVGTVAAGRIGLAVLRRLAPFDVHLHYTDRHRLPESVEKTWHATREDMYPVCDVVTLNCPLHPETEHMINDETLKLFKRGAYIVNTARGKLCDRDAVARALESGRLAGYAGDVWFPQPA-------------PKDHPWRTMPYNGMTPHIS................................. 187
7 -64.900d1qp8a1 c.2.1.4 (A:83-263) Putative formate dehydrogenase {Pyrobaculum aerophilum [TaxId: 13773]}  ali model 3D-neighbors follow..  23  1......................................................................................................ADAVAEFALALLLAPYKRIIQYGEKMKRGDYG--RDVEIPLIQGEKVAVLGLGEIGTRVGKILAALGAQVRGFSRTPKEGP--WRFTNSLEEALREARAAVCALPLNKHTRGLVKYQHLALMAEDAVFVNVGRAEVLDRDGVLRILKERPQFIFASDVWWGRNDF------------AKDAEFFSLPNVVATPWVA................................. 180
8 -47.300d1j4aa2 c.23.12.1 (A:2-103,A:301-332) D-lactate dehydrogenase {Lactobacillus helveticus [TaxId: 1587]}  ali model 3D-neighbors follow..  24  2.KIFAYAIREDEKPFLKEWEDAHKDVEVEYTDKLLTPETVALAKGADGVVVYQQLDYIAETLQALADNGITKMSLRNVGVDNIDMAKAKELGFQITNVPVYSXYTTHAVRNMVVKAFDNNLELVEGKEAETPVKV.................................................................................................................................................................................................... 135
9 -45.700d1dxya2 c.23.12.1 (A:1-100,A:300-330) D-2-hydroxyisocaproate dehydrogenase {Lactobacillus casei [TaxId: 1582]}  ali model 3D-neighbors follow..  25  1MKIIAYGARVDEIQYFKQWAKDT-GNTLEYHTEFLDENTVEWAKGFDGINSLQTTPYAAGVFEKMHAYGIKFLTIRNVGTDNIDMTAMKQYGIRLSNVPAYXTETAVHNMVYFSLQHLVDFLTKGETSTEVT....................................................................................................................................................................................................... 131
10 -35.400d1sc6a2 c.23.12.1 (A:7-107,A:296-326) Phosphoglycerate dehydrogenase {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  10  4.KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVIN--AAEKLVAIGAFAIGTNQVDLDAAAKRGIPVFNAPFSXSTQEAQENIGLEVAG-KLIKYSDNGSTLSAVN..................................................................................................................................................................................................... 133
11 -35.000d1mx3a2 c.23.12.1 (A:28-125,A:319-352) Transcription corepressor CtbP {Human (Homo sapiens), Ctbp1 [TaxId: 9606]}  ali model 3D-neighbors follow..  15  2.LVALLDGRDCT---VEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKF--KALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVXYSEQASIEMREEAAREIRRAITGRIPDSLK..................................................................................................................................................................................................... 129
12 -34.900d1ygya2 c.23.12.1 (A:3-98,A:283-316) Phosphoglycerate dehydrogenase {Mycobacterium tuberculosis [TaxId: 1773]}  ali model 3D-neighbors follow..  17  2.LPVVLIADKLAPSTVAALGD---QVEVRWVDGPDRDKLLAAVPEADALLVRSATTVDAEVLA--AAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSXASAEAQDRAGTDVAESVRLALAGEFVPDAVNV..................................................................................................................................................................................................... 130
13 -32.300d1gdha2 c.23.12.1 (A:2-100,A:292-321) D-glycerate dehydrogenase {Hyphomicrobium methylovorum [TaxId: 84]}  ali model 3D-neighbors follow..  17  1.KKKILITWPLPEAAMARARESYDVIAHGDDPKITIDEMIETAKSVDALLITLNEKCRKEVIDRI-PENIKCISTYSIGFDHIDLDACKARGIKVGNAPHGXATQAREQANDLIDALFGGADMSYALA........................................................................................................................................................................................................... 130
14 -30.100d1li4a1 c.2.1.4 (A:190-352) S-adenosylhomocystein hydrolase {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  19  6...............................................................................................................................CRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAGYEVTTMDEACQEGNIFVT----TTGCIDIILGRHFEQMKDDAIVCNIGHFD-IDVKWLNENAVEKVNIKPQVDRYRLKNG................................................................. 144
15 -25.700d2naca2 c.23.12.1 (A:1-147,A:336-374) Formate dehydrogenase {Pseudomonas sp., strain 101 [TaxId: 306]}  ali model 3D-neighbors follow..  11  44FTPGQLLGSVSGELGLRKLESNGHTLVVTSDKDGPDSVFERELVDADVVISQPPAYLTPERIA--KAKNLKLALTAGIGSDHVDLQSAIDRNVTVAEVTYCNSXTTLTAQARYAAGT-REILECFFEGRPIRDE-YLIVQGGALA.......................................................................................................................................................................................... 187
16 -25.200d1qp8a2 c.23.12.1 (A:1-82,A:264-302) Putative formate dehydrogenase {Pyrobaculum aerophilum [TaxId: 13773]}  ali model 3D-neighbors follow..  15  1MELYVNFELPPE--------------AEEELRKYFKIVRGGDLGNVEAALVS---RITAEELAKM--PRLKFIQVVTAGLDHLPWESIPP-HVTVAGNAGSNXGYGNERVWRQMVMEA---------------------------VRNLITYATGGRPRNIAKREDYIG.................................................................................................................................................................. 122
17 -22.800d1kjqa2 c.30.1.1 (A:2-112) Glycinamide ribonucleotide transformylase PurT, N-domain {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  21  1.........................................................................................................................................TLLGTALAATRVMLLGSGELGKEVAIECQRLGVEVIAVDRYADAPAMH-INMLDGDALRRVVELEKPHY-IVPEIEAIATDMLIQLEEEGLNVVPCARATKLTM.......................................................................................... 111
18 -14.400d4ypoa1 c.2.1.0 (A:1-180) automated matches {Mycobacterium tuberculosis [TaxId: 1773]}  ali model 3D-neighbors follow..  16  12...............................................................................................................................................IQGRKVGVIGYGSQGHAHSLSLRDSGVQVRVGLKQGSRSRPKGLDVDTPAEVAKWADVVMVLAP-DTAQAEIFAGDIEPNLKPGDALFFGHGLNVHFGLIKPPADVA................................................................................. 121
19 -12.800d1saya1 c.2.1.4 (A:136-303) L-alanine dehydrogenase {Phormidium lapideum [TaxId: 32060]}  ali model 3D-neighbors follow..  25  30...............................................................................................................................................VKPGKVVILGGGVVGTEAAKMAVGLGAQVQIFDINVERLSYLESNSAEIETAVAEADLLAVLVP-GRRAPILVPASLVEQMRTGSVIVDVAQGGCVETL......................................................................................... 142
20 -12.200d4gwga1 c.2.1.0 (A:1-176) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  13  3..................................................................................................................................................ADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDF-VGAQSLKEMVSKLKKPRRIILLVKAGQAVDDEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGV....................................................................... 127
21 -12.100d1l7da1 c.2.1.4 (A:144-326) Nicotinamide nucleotide transhydrogenase dI component {Rhodospirillum rubrum [TaxId: 1085]}  ali model 3D-neighbors follow..  19  27...............................................................................................................................................VPPARVLVFGVGVAGLQAIATAKRLGAVVMATDVRAATKEQVEKQAEAVLKELVKTDIATALIP-GKPAPVLITEEMVTKMKPGSVIIDLAAGGNCPLSEPGKIVVKHGVKIVGHTNVPSR................................................................... 183
22 -11.700d3g0oa1 c.2.1.0 (A:6-169) automated matches {Salmonella typhimurium [TaxId: 602]}  ali model 3D-neighbors follow..  20  1.................................................................................................................................................DFHVGIVGLGSMGMGAARSCLRAGLSTWGADLNPQACANLLAE-ASAREFAGVVDALVILVVNAAQVRQVLEDGVAHLMKPGSAVMVSSTISSADAQEIAAALTALNLNMLDAPV....................................................................... 122
23 -11.600d4dlla1 c.2.1.0 (A:29-190) automated matches {Polaromonas sp. [TaxId: 296591]}  ali model 3D-neighbors follow..  17  2................................................................................................................................................YARKITFLGTGSMGLPMARRLCEAGYALQVWNRTPARAASLATIHEQARAAARDADIVVSMLENGAVVQDVLAQGVAAAMKPGSLFLDMASITPREARDHAARLGALGIAHLDTPV....................................................................... 122
24 -11.500d5je8a1 c.2.1.0 (A:1-163) automated matches {Bacillus cereus [TaxId: 226900]}  ali model 3D-neighbors follow..  17  2..................................................................................................................................................KKIGFIGLGNMGLPMSKNLVKSGYTVYGVDLNKEAEASFGIIGLSISKLAETCDVVFTSLPSPRAVEAVYAEGLFENGHSNVVFIDTSTVSPQLNKQLEEAAKEKKVDFLAAPV....................................................................... 121
25 -11.400d2cvza2 c.2.1.6 (A:2-157) Hydroxyisobutyrate dehydrogenase {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  16  1..................................................................................................................................................EKVAFIGLGAMGYPMAGHLARRFPTLVWNRTFEKALQEEFGSEAVPLERVAEARVIFTCLPTTREVYEVAE-ALYPYLREGTYWVDATSGEPEASRRLAERLREKGVTYLDAPV....................................................................... 115
26 -11.200d2gf2a1 c.2.1.0 (A:41-201) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  16  2....................................................................................................................................................VGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANLKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPV....................................................................... 119
27 -11.200d2pv7a2 c.2.1.6 (A:92-243) Prephenate dehydrogenase TyrA {Haemophilus influenzae [TaxId: 727]}  ali model 3D-neighbors follow..  13  1.........................................................................................................................................GFKTINSDIHKIVIVGYGKLGGLFARYLRASGYPISILDREDWAVAE---------SILANADVVIVSVPINLTLETI--ERLKPYLTENMLLADLTSVKREPLAKMLEVHTGAVLGLHPM......................................................................... 111
28 -11.200d2i76a2 c.2.1.6 (A:2-154) Hypothetical protein TM1727 {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  12  1...................................................................................................................................................VLNFVGTGTLTRFFLECLKDRYEIGYILSRSIDRARNLGGKAATLEKHPELNGVVFVIVP-----DRYIKTVANHLNLGDAVLVHCS-GFL--SSEIFKKSGRASI.............................................................................. 102
29 -10.700d1i36a2 c.2.1.6 (A:1-152) Conserved hypothetical protein MTH1747 {Methanobacterium thermoautotrophicum [TaxId: 145262]}  ali model 3D-neighbors follow..  18  1..................................................................................................................................................LRVGFIGFGEVAQTLASRLRSRGVEVVTSLEGRSPSTIERARTVGVEEDVYSCPVVISAVTPGVA----LGAARRAGRHVRGIYVDINNISPETVRMASSLIEKGGFVDAAI......................................................................... 112
30 -10.600d3ws7a1 c.2.1.0 (A:1-161) automated matches {Pyrobaculum calidifontis [TaxId: 410359]}  ali model 3D-neighbors follow..  14  1..................................................................................................................................................MRVGFIGLGIMGGPMATHLLKAGFLAAVYNRTREKTKPFVYVAESPADLAKRVDVVIVMVSDAPDVEQVLPSGVVEGARPGLIVVDMSTNSPDWARKFAERLAQYGIEFLDAPV....................................................................... 120
31 -10.600d3etja2 c.30.1.1 (A:1-78) N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  16  2..................................................................................................................................................KQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDA-----------EPAAVPFQQSVITAEIERWPET....................................................................................................................... 56
32 -10.500d2uyya1 c.2.1.0 (A:262-429) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  14  7..................................................................................................................................................KKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFARLGRTPAEVVSTCDITFACVSDPKAAKDLVPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPV....................................................................... 126
33 -10.500d2dapa1 c.2.1.3 (A:1-118,A:269-320) Diaminopimelic acid dehydrogenase (DAPDH) {Corynebacterium glutamicum [TaxId: 1718]}  ali model 3D-neighbors follow..  18  1...............................................................................................................................................MTNIRVAIVGYGNLGRSVEKLIAKQDMDLVGFSRRATLDTKTPVDVADVDKHADDVDVLFLCMGFAQFACTVDTYDNHRDIPRHRQVMNEAATAIAFGRAAHRMKQQGQSGAFTV......................................................................... 150
34 -10.400d2f1ka2 c.2.1.6 (A:1-165) Prephenate dehydrogenase TyrA {Synechocystis sp. PCC 6803 [TaxId: 1148]}  ali model 3D-neighbors follow..  17  1..................................................................................................................................................MKIGVVGLGLIGASLAGDLRRRGHYLIGVSRQQSTCEKA--EAGQDLSLLQTAKIIFLCTPIQLILPTL--EKLIPHLSPTAIVTDVAKTAIAEPAS-MAGTAAQGIDGAEENLFVNAPYVLTPTEYTDPEQLACLRSVLE............................................ 156
35 -10.300d1c1da1 c.2.1.7 (A:149-349) Phenylalanine dehydrogenase {Rhodococcus sp., M4 [TaxId: 1831]}  ali model 3D-neighbors follow..  29  24..............................................................................................................................................SLDGLTVLVQGLGAVGGSLASLAAEAGAQLLVADTDTEHAVALGHTAVALEDVLSPCDV----------------------------FAPCAMGGVITTEVA-RTLDCSVVAGAA----------------NNVIADEAASDILHARGILYAPDFVANA.............................. 141
36 -9.840d3vpxa2 c.2.1.0 (A:145-363) automated matches {Sporosarcina psychrophila [TaxId: 1476]}  ali model 3D-neighbors follow..  24  26..............................................................................................................................................SLAGKTVAVQGVGNVAYALCEYLHEEGAKLIITDAVQRAVDAFGATAVGINEIYSEADI----------------------------FAPCALGAIINDETI-PQLKAKVIAGSA----------------NNQLKETRHGDLIHEMGIVYAPDYVINS.............................. 144
37 -9.750d3fr7a1 c.2.1.0 (A:86-307) automated matches {Oryza sativa [TaxId: 39947]}  ali model 3D-neighbors follow..  19  38...............................................................................................................................................KGIKQIGVIGWGSQGPAQAQNLRDSLAEAKSDIVVKAGFTEESGTLGDIWETVSGSDLVLLLIS--DAAQADNYEKIFSHMKPNSILGLSH................................................................................................. 141
38 -9.300d1j5pa4 c.2.1.3 (A:1-108,A:220-241) Hypothetical protein TM1643 {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  13  2...................................................................................................................................................TVLIIGMGNIGKKLVELG---NFEKIYA---RISKDIPGVVRLDEFQVPSDVSTVVECAS-----PEAVKEYSLQILKNPVNYIIISTSAFADEVFRERFFSELKNSPARVFF....................................................................... 105
39 -9.220d1edza1 c.2.1.7 (A:149-319) Methylenetetrahydrofolate dehydrogenase/cyclohydrolase {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  14  24............................................................................................................................................GNRLYGKKCIVINRSEVGRPLAALLANDGATVYSVDVNNIQKFTRGESLKLLKKCSLDSDVV---ITGVPSENYKFPTEYI---KEGAVCINFACTKNFSDDVKEKASLYVPMTG............................................................................ 148
40 -9.120d2x5oa1 c.5.1.0 (A:1-93) automated matches {Escherichia coli [TaxId: 668369]}  ali model 3D-neighbors follow..  20  1.............................................................................................................................................ADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLP----DEWLMAADLIVAS-PGIALAHPSLSAAA----DAGIEIVG................................................................................................... 93
41 -9.020d1bg6a2 c.2.1.6 (A:4-187) N-(1-D-carboxylethyl)-L-norvaline dehydrogenase {Arthrobacter, strain 1c [TaxId: 1663]}  ali model 3D-neighbors follow..  17  1.................................................................................................................................................SKTYAVLGLGNGGHAFAAYLALKGQSVLAWDIDAQRIKEIQDR-SDIGLAVKDADVILIVVP--AIHHASIAANIASYISEGQLIILNP-GATGGALEFRKILRENGAPEVTI......................................................................... 129
42 -9.000d1pjqa1 c.2.1.11 (A:1-113) Siroheme synthase CysG, domain 1 {Salmonella typhimurium [TaxId: 90371]}  ali model 3D-neighbors follow..  15  9..............................................................................................................................................QLRDRDCLIVGGGDVAERKARLLLEAGARLTVNALTFIPQFTVWANEGMLEGPFDETLLDSCWLAIAATDDDTVNQRVSDAAESRRIFCNVV................................................................................................. 103
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.