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Query: [M] COG1209 dTDP-glucose pyrophosphorylase, from COG1018

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKMRKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFQQLLGDGSQWGLNLQYKVQPSPDGLAQAFIIGEEFIGGDDCALVLGDNIFYGHDLPKLMEAAVNKESGATVFAYHVNDPERYGVVEFDKNGTAISLEEKPLEPKSNYAVTGLYFYDNDVVQMAKNLKPSARGELEITDINRIYLEQGRLSVAMMGRGYAWLDTGTHQSLIEASNFIATIEERQGLKVSCPEEIAFRKGFIDVEQVRKLAVPLIKNNYGQYLYKMTKDSNLast
1 -95.800d1fxoa_ c.68.1.6 (A:) RmlA (RfbA) {Pseudomonas aeruginosa [TaxId: 287]}  ali model 3D-neighbors follow..  68  2...RKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQDTPRFQQLLGDGSNWGLDLQYAVQPSPDGLAQAFLIGESFIGNDLSALVLGDNLYYGHDFHELLGSASQRQTGASVFAYHVLDPERYGVVEFDQGGKAISLEEKPLEPKSNYAVTGLYFYDQQVVDIARDLKPSPRGELEITDVNRAYLERGQLSVEIMGRGYAWLDTGTHDSLLEAGQFIATLENRQGLK---VACPEEIAYRQKWIDAAQLEKLAKNGYGQYLKRLLTETV. 291
2 -63.700d1tzfa1 c.68.1.13 (A:4-259) Glucose-1-phosphate cytidylyltransferase RfbF {Salmonella typhimurium [TaxId: 90371]}  ali model 3D-neighbors follow..  17  1....KAVILAGGLGTRLSEETIVKPKPMVEIGGKPILWHIMKMYSVHGIKDFIICCGY-KGYVIKEYFANYFLHMSDVTFVDTGDSSMTGGRLKRVAEYVKDDEAFLFTYGDGVADLDIKATIDFHKAHGKKATLTA--TFPPGRFGALDIQ-AGQVRSFQEKPKGD-GAMINGGFFVLNPSVIDLIDN-----DATTWEQEPLMTLAQQGE-LMAFEHPGF-WQPMDTLRDKVYLEGLWEKGKAP............................................... 251
3 -58.800d1yp2a2 c.68.1.6 (A:10-316) Glucose-1-phosphate adenylyltransferase small subunit, catalytic domain {Potato (Solanum tuberosum) [TaxId: 4113]}  ali model 3D-neighbors follow..  22  10.RSVLGIILGGGAGTRLYPLTKKRAKPAVPLGANRLIDIPVSNCLNSNISKIYVLT-QFNSASLNRHLSRAYASNMQQSPENPDWFQGTADAVRQYLWLFEEVLEYLILAGDHLYRMDYEKFIQAHRETDADITVAALPMKRATAFGLMKIDEEGRIIEFAEKPQKEMPFIASMGIYVISKDVMLNLLRDKFPGANDFG-SEVIPGATSLGMRVQAYLYDGY-WEDIGTIEAFYNANLGITKKPVPD.............................................. 292
4 -49.300d1jyka1 c.68.1.13 (A:7-231) CTP:phosphocholine cytidylytransferase LicC {Pneumococcus (Streptococcus pneumoniae) [TaxId: 1313]}  ali model 3D-neighbors follow..  18  1....KAIILAAGLGTRLRPLTENTPKALVQVNQKPLIEYQIEFLKEKGINDIIIIVGY-LKEQFDYL---KEKYGVRLVFNDKYADYNNFYSLYLVKEELANS--YVIDADNYLFKNMFRNDLTRS-------TYFSVYREDCTNEWFLVYGDDYKVQDIIVDSK---AGRILSGVSFWDAPTAEKIVSYVSGEFVDLYWDNMVKDNIKELD-VYVEELEGNSIYEIDSVQDYRKLEEIL..................................................... 224
5 -42.200d1hm9a2 c.68.1.5 (A:2-251) N-acetylglucosamine 1-phosphate uridyltransferase GlmU, N-terminal domain {Pneumococcus (Streptococcus pneumoniae) [TaxId: 1313]}  ali model 3D-neighbors follow..  20  2...NFAIILAAGKGTRMK---SDLPKVLHKVAGISMLEHVFRSVGAIQPEKTVTVVGH-KAELVEEVLAG------QTEFVTQSEQLGTGHAVMMTEPILEGGHTLVIAGDTLITGESLKNLIDFHINHKNVATILTAETDNPFGYGRIVRNDNAEVLRIVEQDFEKQIKEINTGTYVFDNELFEALKNINTNAQGEYYITDVIGIFRETGEKVGAYTLKDFD-LGVNDRVALATAESVMRRRINHKHMVNG......................................... 250
6 -25.300d2cu2a2 c.68.1.20 (A:1-268) Putative mannose-1-phosphate guanylyl transferase (GDP)/mannose-6-phosphate isomerase TTHA1750 {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  15  3...TYALVMAGGRGERLWPLSRDRPKPFLPLFEKTLLEATLERLAPVPPERTLLAVRRDQEAVARPYADG-------IRLLLEPLGRDTAGAVLLGVAEAGAERLLVLPADHYVGDDEALATMLEAAEEGFVVALGLRPTRPETEYGYIRLGPR-RGEGFVEKPSYAEALVWNGGVFAFAPSHHEALERLLAGASLEEVYAGLIDYGVMEKAERVRVVLGRFPWDDVGNWRALERV......................................................... 265
7 -19.300d1h7ea_ c.68.1.13 (A:) CMP:2-keto-3-deoxy-manno-octonic acid (CMP-KDO)synthetase {Escherichia coli, KpsU [TaxId: 562]}  ali model 3D-neighbors follow..  16  5.....IVIPARYGSSRL-------GKPLLDIVGKPMIQHVYERALQVAGVAEVWVATDD-----PRVEQAVQAFGGKAIMTRNDHESGT-DRLVEVMHKVEADIYINLQGDEMIRPRDVETLLQGMRDDPALPVATLCHAISAAEA--VVVNTRQDALYFSRSPAEKARYLKHVGIYAYRRDVLQNYSQLPESMPEQAESLEQLR-LMNAGINIRTFEVAA---PGVDTPACLEKVRALMAQELAENA............................................. 245
8 -17.800d1e5ka_ c.68.1.8 (A:) Molybdenum cofactor biosynthesis protein MobA {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  15  1MTTITGVVLAGGKARRM-----GVDKGLLELNGKPLWQHVADALMTQ-LSHVVVNANRHQEIY--------QASGLKVIEDSLADYPGPLAGMLSVMQQEAGEWFLFCPCDTPYIPPDLAARLNHQRKDAPVVWVHDGERDHPT-------------------------------IALVNRAIEPLLLEYLQAGE-----RRVMVFMRLAGGHAVDFSDHKDAFVNVNTPEELARWQ........................................................ 188
9 -17.600d2vsha_ c.68.1.0 (A:) automated matches {Pneumococcus (Streptococcus pneumoniae) [TaxId: 1313]}  ali model 3D-neighbors follow..  15  1.HMIYAGILAGGTGTRMG--ISNLPKQFLELGDRPILIHTIEKFVLEPIEKIVVGVHGDWVSHAEDLVDKYLP--IIITKGGADRNTSIKNIIEAIDAYRPLTPEDIVVTHDFITLRMIQDNIQLAQNHDAVDTVV------EAVDTIVESTNGQFITDIPNRAHLYQGQTPQT----FRCKDFMDLYGSLSDEEKEILTDAC--KIFVIKGKDVALAKGEYSNLKITTVTDLKIAKSMI..................................................... 233
10 -17.500d2dpwa1 c.68.1.19 (A:1-231) Uncharacterized protein TTHA0179 {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  13  1MRP-SAIVLAGGKEAWAERFG-VGSKALVPYRGRPMVEWVLEALYAAGLSPVYVGENPGLVPAPALTLPDRG---------------GLLENLEQALEHVEGRVLVATGDIPHLTEEAVRFVLDKAPEAALVYPIVPKEAVEARNLLLLDKSLFRKALPLARRVVALRKRPLALARLVGWDVLLKLLLGRLSLAEVEARAQRILGVEAR-----ALVTPYPEVGVDVDREEDLV........................................................... 231
11 -17.100d2y6pa_ c.68.1.0 (A:) automated matches {Aquifex aeolicus [TaxId: 63363]}  ali model 3D-neighbors follow..  18  4.....VIIPARLGSTRL-------EKPLKNLLGKPLIRWVVEGLVKT-GERVILATDSERVKEVVEDLC-------EVFLTPSDLPSGS-DRVLYVVRDLDVDLIINYQGDEFVYEEDIKLIFRELEKGERVVTLARKDKEAYERPEDVKVDREGYALYFSRSPNDTFYPLKHVGIYGFRKETLMEFGAMPPSKLEQIEGLEQLR-LLENGIKIKVLITENYY-HGVDTEEDLKIVEEKL..................................................... 230
12 -17.100d2yc3a1 c.68.1.13 (A:76-300) 4-diphosphocytidyl-2C-methyl-D-erythritol (CDP-me) synthase (IspD, YgbP) {Thale cress (Arabidopsis thaliana), chloroplast [TaxId: 3702]}  ali model 3D-neighbors follow..  17  2.KSVSVILLAGGQGKRMK---MSMPKQYIPLLGQPIALYSFFTFSRMPVKEIVVVCDPFFRDIFEEYE---ESIDVDLSFAIPGKER--QDSVYSGLQEIDVNSELVCIHDSLVNTEDVEKVLKDGSAVG--AAVLGVPAKAT----IKEVNSDSLVVKTLDRKT-----------EMQTPQVIKLKKGFELVKSEGLEVTD--VSIVEYLKHPVYVSQGSYTNIKVTTPDDLLLAERILSE................................................... 225
13 -16.700d4kt7a1 c.68.1.0 (A:1-230) automated matches {Anaerococcus prevotii [TaxId: 525919]}  ali model 3D-neighbors follow..  15  5.KFISAIITAAGSGLRMR---SKINKPYIEVGGRKVLEITLDTVSRVKIDEIILVIRKDDEDIIKDIL---EKYDGNIRYVYGSTTR--ELSTFEGLKALDPQSELVLTHDGVASEELFLKTINALRKNK--AVITATKSKDT----VKIIDDDMYVDFTPNRDY-----------NIQTPQAFDIYAMYEKYLASEFKVTDDSQLFEFFDRDEKVKVVHGEY-IKITTQEDIIFANAYLQR................................................... 230
14 -16.600d5ddta_ c.68.1.0 (A:) automated matches {Bacillus subtilis [TaxId: 224308]}  ali model 3D-neighbors follow..  16  5.....VVIPAAGQGKRMK---AGRNKLFIELKGDPVIIHTLRVFDSHRCDKIILVINEQEREHFQQLL---SDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLVHDG-FIKHEQIDELIAEAEQTG--AAILAVPVKD-----TIKRVQDLQVSETIERSS-----------AVQTPQAFRLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTSAEAIMESESGNKHV............................................ 232
15 -16.200d2xwla1 c.68.1.0 (A:2-219) automated matches {Mycobacterium smegmatis [TaxId: 1772]}  ali model 3D-neighbors follow..  17  4.....AVVPAAGSGERLR---AGRPKAFVTLGGTPLLEHALSGLRASGIDRIVIAVPPALTDESKLVFGGEDSVIVS----------GVTESVALALEAAGDAEFVLVHDA-LTPPALIARVVAALKEGHSAVVPGL-----APADTIKAVDANGAVLGTPERAG-----------AVQTPQGFHADVLRRAYARATAGGVTDDASLVEQLGTPVQIVDGDPLAFKITTPLDLVLAEAVL..................................................... 217
16 -16.000d4myba_ c.68.1.0 (A:) automated matches {Francisella tularensis [TaxId: 263]}  ali model 3D-neighbors follow..  14  5.....VIIPAAGIGTRMQ---LDIPKQYYKLNGKTILDNTLVKFIDNPFDKIFVAIAASDNFWNNSLYYNHDK--IVVCNGGETRFNSVYNALNVIDERKNDD--WVFVHDAAVSIDSIIDLYEQTKSSHSQAGILAVRAYE-----TVKQVTKNIVVKTLARDNIWLAQT-----QLSRLGQLEKAFDFCYSNNLVAKVTD--ASALEMFGINPIVVECSKKNIKITTKDDLEYANWQL..................................................... 227
17 -15.600d1i52a_ c.68.1.13 (A:) 4-diphosphocytidyl-2C-methyl-D-erythritol (CDP-me) synthase (IspD, YgbP) {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  15  6.....AVVPAAGFGRRMQ---TECPKQYLSIGNQTILEHSVHALLAHPVKRVVIAISPGDSRFAQLPLANHPQITVVDGGDERAD------SVLAGLKAAGDAQWVLVHDA-CLHQDDLARLLALSETSRTGGILAAPVRDTMKRAE----PGKNAIAHTVDRNG-----------HALTPQFFPLHDCLTRALNEGATITD--ASALEYCGFHPQLVEGRADNIKVTRPEDLALAEFYLTR................................................... 225
18 -15.600d1vpaa1 c.68.1.13 (A:1-219) 4-diphosphocytidyl-2C-methyl-D-erythritol (CDP-me) synthase (IspD, YgbP) {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  15  1..MNVAILLAAGKGERMS---ENVPKQFLEIEGRMLFEYPLSTFLKSEIDGVVIVTRREWFEVVEKRVFHEKV--LGIVEGGDTRSQSVRSALEFLEK---FSPSYVLVHDSALRKKHVSEVLRRARETG--AATLALKNSDALV------RVENDRIEYIPRKG----------YRILTPQAFSYEILKKAHENGGEWADDT--EPVQKLGVKIALVEGDPLCFKVTFKEDLELARIIAREWE................................................. 219
19 -15.200d1qwja_ c.68.1.13 (A:) CMP acylneuraminate synthetase {Mouse (Mus musculus) [TaxId: 10090]}  ali model 3D-neighbors follow..  13  6.....ALVLARG-GSKGIP------KNIKRLAGVPLIGWVLRAALDAGVFQSVWVSTDH-----DEIENVAKQFGAQVHRRSSETSKDSSDAIVEFLNYHNEVDIVGNITSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQF-RWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFY-------------FAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRFGYFGK............................................. 228
20 -14.200d1ezia_ c.68.1.13 (A:) CMP acylneuraminate synthetase {Neisseria meningitidis [TaxId: 487]}  ali model 3D-neighbors follow..  13  7.....AVILARQ-NSKGLP-----LKNLRKMNGISLLGHTINAAISSKCFDRIIVSTDG-----GLIAEEAKNFGVEVVLELASDTASSISGVIHALETIGSNSGTVTLTSPLRTGAHIREAFSLFDEKIKGSVVSACPMEHH-PLKTLLQINNGEYAPMRHLSDLEQPRQQLPQAFRPNGAIY-INDTASLIANNCFFIAPTKLYIMSHQDSI-----------DIDTELDLQQAENIL..................................................... 223
21 -14.200d2icya2 c.68.1.5 (A:5-383) UDP-glucose pyrophosphorylase 2 (UDPGP 2) {Thale cress (Arabidopsis thaliana) [TaxId: 3702]}  ali model 3D-neighbors follow..  10  73LDKLVVLKLNGGLGTTM----CTGPKSVIEVDGLTFLDLIVIQIENLNNKPLVLMNSFNTHDDTHKIVEKYTNSNVDIHTFNQSKPPGHGDVFPALMN--GKEYVFVANSDNLGAIVDLTILKHLIQNKNEYCMEVTPKTLADVKGGLISYEGKVQLLEIAQVPDEHVNEIFNTNNLWVNLKAIKIPNPKEVDGVKVLQLETAAGAAIRFFDNAIGVNVPRSRFLPVKASSDLLLVQSDLYTLVDG............................................... 374
22 -13.500d2e8ba_ c.68.1.8 (A:) Molybdenum cofactor biosynthesis protein MobA {Aquifex aeolicus [TaxId: 224324]}  ali model 3D-neighbors follow..  13  10.KVNTCYVLAGGKSKRF-----GEDKLLYEIKGKKVIERVYETAKSV-FKEVYIVAKDREK----------SFLNAPV-VLDEFEESASIIGLYTALKHAKEENVFVLSGDLPLMKKET---VLYVLENFKEPVSVAKTEKLHTLVGVYSKKLLEKIEERIKKGDYRIWALL......................................................................................................................... 161
23 -12.600d1w55a1 c.68.1.13 (A:3-207) IspD/IspF bifunctional enzyme, CDP-me synthase domain {Campylobacter jejuni [TaxId: 197]}  ali model 3D-neighbors follow..  17  2...MSLIMLAAGNSTRFN---TKVKKQFLRLGNDPLWLYATKNLSSFYFKKIVVTSSNITYMK-------------KFTKNYEFIEGGDTRAESLKKALELIDSEFVMVSDVAVSKNLFDRLIE--NLDKADCITPALKVADTTLFDNEALQREK--IKLIQTPQISKTKLLKKAL------------------DQNLEFTDDSTAIAAMGGKIWFVEGE----RKLTFKEDLKKLDLPTPS................................................... 205
24 -11.600d1jvga_ c.68.1.5 (A:) UDP-N-acetylglucosamine pyrophosphorylase {Human (Homo sapiens), AGX2 [TaxId: 9606]}  ali model 3D-neighbors follow..  17  99QNKVAVLLLAGGQGTRL----VAYPKGMYDVSRKTLFQIQAERILKLQ--PWYIMTSGRTMESTKEFFTKHKYFGLNVIFFQQGAPDGNGGLYRALAA--GIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNA................................................................................................................ 324
25 -11.100d2yqca_ c.68.1.0 (A:) automated matches {Yeast (Candida albicans) [TaxId: 5476]}  ali model 3D-neighbors follow..  16  99NGEVAVLLMAGGQGTRL----SSAPKGCFNISQKSLFQIQAEKILKI---NWYIMTSGPTRNATESFFIENNYFGLQVIFFNQGSPDGNGGLYKALKD--GIKHIHMYCVDNCLVKVADPIFIGFAIAKKFDLATVVRKRDANESVGLIVLDQDNQKPCVIEDSSKLFLRAANIVNHYYSVEFLNKMIPKWISSQKYL............................................................................................... 358
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Damiano JS, Stehlik C, Pio F, Godzik A., Reed JC. CLAN, a novel human CED-4-like gene. Genomics. 2001 Jul;75(1-3):77-83.