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Query: [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases, from COG1018

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst METIGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLADLVAKGLKTVSGHAAVAKAADIIITMVPDTPQVADVLFGDNGVASGLTRGKLVIDMSSISPIETKVFAGKINELGCDYLDAPVSGGEVGAKAASLTIMVGGEEKAFERAKPVFEKMGKNITLVGPNGVGQTTKVANQIVVALTIEAVAEALVFASKAGADPARVRQALMGGLAASRILEVHGERMVKRTFAPGFRIELHQKDLNLALEGAKALGVSLPNTSTTQQLFNSCAANGGAREDHSALVRALERMANFEVGGAVAEVKGKAALast
1 -68.600d5je8a1 c.2.1.0 (A:1-163) automated matches {Bacillus cereus [TaxId: 226900]}  ali model 3D-neighbors follow..  34  1MKKIGFIGLGNMGLPMSKNLVKSGYTVYGVDLNKEAEASFEKEGGIIGLSISKLAETCDVVFTSLPSPRAVEAVYFGAEGLFENGHSNVVFIDTSTVSPQLNKQLEEAAKEKKVDFLAAPVSGGVIGAENRTLTFMVGGSKDVYEKTESIMGVLGANIFHVSE.............................................................................................................................................. 163
2 -68.500d2gf2a1 c.2.1.0 (A:41-201) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  39  1..PVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGA.............................................................................................................................................. 161
3 -67.800d3ws7a1 c.2.1.0 (A:1-161) automated matches {Pyrobaculum calidifontis [TaxId: 410359]}  ali model 3D-neighbors follow..  43  2..RVGFIGLGIMGGPMATHLLKAGFLAAVYNRTREKTKPFAEAGVYVAESPADLAKRVDVVIVMVSDAPDVEQVLFGPSGVVEGARPGLIVVDMSTNSPDWARKFAERLAQYGIEFLDAPVTGGQKGAIEGTLTIMVGGKEELFHRLLPIFKAMGRDIVYMG............................................................................................................................................... 161
4 -66.800d2uyya1 c.2.1.0 (A:262-429) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  29  7.KKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGE.............................................................................................................................................. 168
5 -64.600d4dlla1 c.2.1.0 (A:29-190) automated matches {Polaromonas sp. [TaxId: 296591]}  ali model 3D-neighbors follow..  40  4.RKITFLGTGSMGLPMARRLCEAGYALQVWNRTPARAASLAALGATIHEQARAAARDADIVVSMLENGAVVQDVLFA-QGVAAAMKPGSLFLDMASITPREARDHAARLGALGIAHLDTPVSGGTVGAEQGTLVIMAGGKPADFERSLPLLKVFGR-ATHVG............................................................................................................................................... 162
6 -64.400d3g0oa1 c.2.1.0 (A:6-169) automated matches {Salmonella typhimurium [TaxId: 602]}  ali model 3D-neighbors follow..  34  3..HVGIVGLGSMGMGAARSCLRAGLSTWGADLNPQACANLLAEGACAAASAREFAGVVDALVILVVNAAQVRQVLFGEDGVAHLMKPGSAVMVSSTISSADAQEIAAALTALNLNMLDAPVSGGAVKAAQGEMTVMASGSEAAFTRLKPVLDAVASNVYRISD.............................................................................................................................................. 164
7 -57.500d2cvza2 c.2.1.6 (A:2-157) Hydroxyisobutyrate dehydrogenase {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  35  1.EKVAFIGLGAMGYPMAGHLARRFPTL-VWNRTFEKALRHQEEFGSEA-VPLERVAEARVIFTCLPTTREVYEVA---EALYPYLREGTYWVDATSGEPEASRRLAERLREKGVTYLDAPVSGGTSGAEAGTLTVMLGGPEEAVERVRPFL-AYAKKVVHVGP.............................................................................................................................................. 156
8 -52.000d4gwga1 c.2.1.0 (A:1-176) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  20  3.ADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGP-SLMPGGNKEAWPHIKTIFQGIAAKVGTGEP-CCDWV........................................................................................................................................ 173
9 -49.100d1teaa4 a.100.1.1 (A:164-296) Hydroxyisobutyrate dehydrogenase {Salmonella typhimurium [TaxId: 90371]}  ali model 3D-neighbors follow..  43  1..................................................................................................................................................................DIGAGNVTKLANQVIVALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIKDLANALDTSHGVGAQLPLTAAVMEMMQALRADGHGNDDHSALACYYEKLAKVEVTR.......... 133
10 -47.200d4dlla2 a.100.1.0 (A:191-316) automated matches {Polaromonas sp. [TaxId: 296591]}  ali model 3D-neighbors follow..  46  1..................................................................................................................................................................PHGSGQLTKLANQMIVGITIGAVAEALLFATKGGADMAKVKEAITGGFADSRVLQLHGQRMVERDFAPRARLSIQLKDMRNALATAQEIGFDAPITGLFEQLYAEGVEHGLTDLDQSGLFVELAS.................. 125
11 -46.600d3ws7a2 a.100.1.0 (A:162-283) automated matches {Pyrobaculum calidifontis [TaxId: 410359]}  ali model 3D-neighbors follow..  34  1..................................................................................................................................................................PVGYGQAMKLVNQVVVALNTVAMVEGLKLAKALGLDMDKVAEVLTRGAARSGAIELYLPKLLKGDLSPGFKAEHLKKDLGYVLEEARKRGVKLPGAELAYELYRKMVEDGAGSLGIHALGFY..................... 122
12 -45.700d3ckya2 a.100.1.0 (A:167-300) automated matches {Eubacterium barkeri [TaxId: 1528]}  ali model 3D-neighbors follow..  34  1...................................................................................................................................................................TGAGDAVKIVNNLLLGCNMASLAEALVLGVKCGLKPETMQEIIGKSSGRSYAMEAKMEKIMSGDFAGGFAMDLQHKDLGLALEAGKEGNVPLPMTAMATQIFEGGRAMGLGREDMSAVIKVWEQMTGVSVSG.......... 133
13 -45.500d2cvza1 a.100.1.1 (A:158-289) Hydroxyisobutyrate dehydrogenase {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  22  1...................................................................................................................................................................VGAGHAVKAINNALLAVNLWAAGEGLLALVKQGVSAEKALEVINASSGRSNATENLIPQVLTRAFPKTFALGLLVKDLGIAMGVLDGEKAPSPLLRLAREVYEMAKRELGPDADHVEALRLLERWGGVEIR........... 132
14 -45.500d2uyya2 a.100.1.0 (A:430-553) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  23  1...................................................................................................................................................................VGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH.................. 124
15 -45.200d3g0oa2 a.100.1.0 (A:170-292) automated matches {Salmonella typhimurium [TaxId: 602]}  ali model 3D-neighbors follow..  29  1..................................................................................................................................................................TPGAGSTVKIIHQLLAGVHIAAAAEAMALAARAGIPLDVMYDVVTHAAGNSWMFENRMQHVVDGDYTPRSAVDIFVKDLGLVADTAKALRFPLPLASTALNMFTSASNAGYGKEDDSAVIKIF.................... 123
16 -45.000d3cuma4 a.100.1.1 (A:163-296) Hydroxyisobutyrate dehydrogenase {Pseudomonas aeruginosa [TaxId: 208964]}  ali model 3D-neighbors follow..  28  1..................................................................................................................................................................PDGAGQVAKVCNNQLLAVLMIGTAEAMALGVANGLEAKVLAEIMRRSSGGNWALEVYNPAPASRDYSGGFMAQLMAKDLGLAQEAAQASASSTPMGSLALSLYRLLLKQGYAERDFSVVQKLFDP.................. 132
17 -44.200d5je8a2 a.100.1.0 (A:164-291) automated matches {Bacillus cereus [TaxId: 226900]}  ali model 3D-neighbors follow..  25  1..................................................................................................................................................................QIDSGTTVKLINNLLIGFYTAGVSEALTLAKKNNMDLDKMFDILNVSYGQSRIYERNYKSIAPENYEPGFTVNLLKKDLGFAVDLAKESELHLPVSEMLLNVYDEASQAGYGENDMAALYKKVSE.................. 126
18 -40.400d1i36a2 c.2.1.6 (A:1-152) Conserved hypothetical protein MTH1747 {Methanobacterium thermoautotrophicum [TaxId: 145262]}  ali model 3D-neighbors follow..  21  2..RVGFIGFGEVAQTLASRLRSRGVEVVTSLEGRSPSTIERARTVGVTETSEEDVYSCPVVISAVTPGVALGAARRAGRHV------RGIYVDINNISPETVRMASSLIEKGG--FVDAAIMGSVRRKGADIRIIASGRDAEEFMKLNR----YGLNIEVRGR.............................................................................................................................................. 150
19 -38.700d4ypoa1 c.2.1.0 (A:1-180) automated matches {Mycobacterium tuberculosis [TaxId: 1773]}  ali model 3D-neighbors follow..  16  15.RKVGVIGYGSQGHAHSLSLRDSGVQVRVGLKQGSRSRPKVEEQGLDVDTPAEVAKWADVVMVLAPDTAQAEIFA---GDIEPNLKPGDALFFGHGLNVHFGLIKPPADVAVAMVAPKGPGHLVRRQFVDGLVAVEQDPRGDGLALALSYAKAIGGTRAGVIKT............................................................................................................................................. 179
20 -31.300d2i76a2 c.2.1.6 (A:2-154) Hypothetical protein TM1727 {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  11  1..VLNFVGTGTLTRFFLECLKDRYEIGYILSRSIDRARNLAEVYGGKAATLEKHPELNGVVFVIVPD-RYIKTV------ANHLNLGDAVLVHCSGF---LSSEIFKKSGRASIHPNFSFSSLEKALEMKDQIVFGLEGDERGLPIVKKIAEEISGKYFVIPS.............................................................................................................................................. 151
21 -18.500d2pv7a2 c.2.1.6 (A:92-243) Prephenate dehydrogenase TyrA {Haemophilus influenzae [TaxId: 727]}  ali model 3D-neighbors follow..  18  9IHKIVIVGYGKLGGLFARYLRASGYPISILDREDW-------------AVAESILANADVVIVSVPINLTLETI----ERLKPYLTENMLLADLTSVKREPLAKMLEVHTGAVLGL---PMFGADIASMAKQVVVRCGRFPERYEWLLEQIQIWGAKIYQT................................................................................................................................................ 152
22 -18.000d2f1ka2 c.2.1.6 (A:1-165) Prephenate dehydrogenase TyrA {Synechocystis sp. PCC 6803 [TaxId: 1148]}  ali model 3D-neighbors follow..  20  2..KIGVVGLGLIGASLAGDLRRRGHYLIGVSRQQSTCEKAVERQLDEAGQDLSLLQTAKIIFLCTPIQLILPTL----EKLIPHLSPTAIVTDVASVK----TAIAEPASQLWSGFIGGPMAGTAAQGIDGALTPTEYTDPEQLACLRSVLEPLGVKIYLC................................................................................................................................................ 165
23 -17.700d1jaya_ c.2.1.6 (A:) Coenzyme F420H2:NADP+ oxidoreductase (FNO) {Archaeoglobus fulgidus [TaxId: 2234]}  ali model 3D-neighbors follow..  13  2..RVALLGTGNLGKGLALRLATLGHEIVVGSRREEKAEAKAAEASITGMKNEDAAEACDIAVLTIPWEHAIDTA-------LKNILREKIVVSPLVPVSRGAKGFTYSSERSAAEIVAEVLESEKVVSALHTIVPVCGDDDESKKVVMSLISEIGLRPLDAGPLSNSRLVESLTPLILNIM............................................................................................................................ 199
24 -16.100d2ahra2 c.2.1.6 (A:1-152) Pyrroline-5-carboxylate reductase ProC {Streptococcus pyogenes [TaxId: 1314]}  ali model 3D-neighbors follow..  16  2..KIGIIGVGKMASAIIKGLKQTPHELIISGSSLERSKEIAEQALPYAMSHQDLIDQVDLVILGI-KPQLFETV-------LKPLHFKQPII--SMAAGISLQRLATFVGQDLPLLRIMPNMNAQILQSSTALTGNALVSQELQARVRDLTDSFGSTF................................................................................................................................................... 148
25 -15.900d2g5ca2 c.2.1.6 (A:30-200) Prephenate dehydrogenase TyrA {Aquifex aeolicus [TaxId: 63363]}  ali model 3D-neighbors follow..  19  1MQNVLIVGVGFMGGSFAKSLRRSGFKIYGYDINPESISKAVDLGIGTTSIAKVEDFSPDFVMLSSPVRTFREIA----KKLSYILSEDATVTDQGSVKGKLVYDLENILGKRFVG----PIAGTEKSGVEYSLTPTKKTDKKRLKLVKRVWEDVGGVVEYM................................................................................................................................................ 171
26 -15.500d3daga1 c.2.1.6 (A:1-242) 5,10-methenyltetrahydromethanopterin hydrogenase, HMD {Methanocaldococcus jannaschii [TaxId: 2190]}  ali model 3D-neighbors follow..  13  60VIVSDPCFAEEPGLVVIDEFPKEVMEAHLSGNPESIMPKPEDVGLKVTSDDREAVEGADIVITWLPKGNKQPDII---KKFADAIPEGAIVTHACTIPTTKFAKIFKDLGREDLNITSYPGCVPEMKGQV--YIAEGYASEEAVNKLYEIGKIARGKAFKM................................................................................................................................................ 241
27 -15.100d3fr7a1 c.2.1.0 (A:86-307) automated matches {Oryza sativa [TaxId: 39947]}  ali model 3D-neighbors follow..  15  41.KQIGVIGWGSQGPAQAQNLRDSLAEAKSDRKGSKSFDEARAAGFGTLGDIWETVSGSDLVLLLISDAAQADNY----EKIFSHMKPNSILGLSHGFLLGHLQSAGLDFPKNISVIAVCPKGMGPSAGINSSFAVHQDVDGRATDVALGWSVALGSP.................................................................................................................................................... 216
28 -14.300d2naca1 c.2.1.4 (A:148-335) Formate dehydrogenase {Pseudomonas sp., strain 101 [TaxId: 306]}  ali model 3D-neighbors follow..  12  45.MHVGTVAAGRIGLAVLRRLAPFDVHLHYTDRHRLPESVEKELNLTWHATREDMYPVCDVVTLNCPLHPETEHMI--NDETLKLFKRGAYIVNTARGKLCDRDAVARALESGRLAGYAGDVWFPQPAPKDHPWRTMISG...................................................................................................................................................................... 188
29 -14.100d3tria1 c.2.1.0 (A:2-162) automated matches {Coxiella burnetii [TaxId: 777]}  ali model 3D-neighbors follow..  19  3.SNITFIGGGNMARNIVVGLIANGYRICVTNRSLDKLDFFKEKGVHTTQDNRQGALNADVVVLAV-KPHQIKMVC---EELKDILSETKILV-ISLAVGVTTPLIEKWLGKASRIVRAMPNTPSSVRAGATGLFANETVDKDQKNLAESIMRAVGLVI................................................................................................................................................... 158
30 -13.800d2izza1 c.2.1.0 (A:1-164) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  13  2..SVGFIGAGQLAFALAKGFTAAGVKIMASSPDMDLATVSALRGVKLTPHNKETVQHSDVLFLAV-KPHIIPFIL---DEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCT................................................................................................................................................... 160
31 -13.700d5bsea1 c.2.1.0 (A:3-169) automated matches {Medicago truncatula [TaxId: 3880]}  ali model 3D-neighbors follow..  20  9.YTLGFIGAGKMAESIAKGAVRSGVRIKTAIHSNPARRTAFESGITVLSSNDDVVRDSNVVVFSV-KPQLLKDVV---LKLKPLLTKDKLLV--SVAAGIKMKDLQEWAGHERFIRV-MPNTAATVGEAASVMSLGGAATEEDANLISQLFGSIGKIW................................................................................................................................................... 163
32 -13.300d1mv8a2 c.2.1.6 (A:1-202) GDP-mannose 6-dehydrogenase {Pseudomonas aeruginosa [TaxId: 287]}  ali model 3D-neighbors follow..  16  2..RISIFGLGYVGAVCAGCLSARGHEVIGVDVSSTKIDLIQTGRLSGTTDFKKAVLDSDVSFICVGTPSKIETVCREIGFAIREKSERHTVVVRSTVLPGTVNNVVIPLIEDCSGKVDFGVGTNPEFLRESTAITVIGEDKQTGDLLEEIYRELDAPIIRKT............................................................................................................................................... 202
33 -13.300d1evya2 c.2.1.6 (A:9-197) Glycerol-3- phosphate dehydrogenase {Trypanosome (Leishmania mexicana) [TaxId: 5665]}  ali model 3D-neighbors follow..  13  7LNKAVVFGSGAFGTALAMVLSKKCREVCVWHMNEEEVRLVLASNITFTSDVEKAYNGAEIILFVIPTGGNLIAYAKEKQVPVLVCTKG---IERSTLK-FPAEIIGEFLPSPLLSVLAGPSFAIEVATGVFTCVSIASADINVARRLQRIMST........................................................................................................................................................ 179
34 -13.300d1gdha1 c.2.1.4 (A:101-291) D-glycerate dehydrogenase {Hyphomicrobium methylovorum [TaxId: 84]}  ali model 3D-neighbors follow..  13  48.KTLGIYGFGSIGQALAKRAQGFDMDIDYFDTHRASSSDEASYQATFHDSLDSLLSVSQFFSLNAPSTPETRYFF--NKATIKSLPQGAIVVNTARGDLVDNELVVAALEAGRLAYAGFDVFAGEPNINEGYYDL.......................................................................................................................................................................... 179
35 -13.200d3k96a1 c.2.1.0 (A:3-180) automated matches {Coxiella burnetii [TaxId: 227377]}  ali model 3D-neighbors follow..  15  4.HPIAILGAGSWGTALALVLARKGQKVRLWSYESDHVDEMFPETLKAYCDLKASLEGVTDILIVVP-SFAFHEVI---TRMKPLIDAKTRIAWGTK-SRLLHEVVATELGQVPMAVISGPSLATEVAANLPTAVSLASNNSQFSKDLIERLHG........................................................................................................................................................ 169
36 -12.900d1xc2a3 c.2.1.6 (A:1-152) Pyrroline-5-carboxylate reductase ProC {Neisseria meningitidis, serogroup B [TaxId: 487]}  ali model 3D-neighbors follow..  14  2..NVYFLGGGNMAAAVAGGLVKQGYRIYIANRGAEKRERLEKELGVETSATLPELHSDDVLILAV-KPQDMEAA-------CKNIRTNGALV-LSVAAGLSVGTLSRYLGGTRRIVRVMPNTPGKIGLGVSGMYAEAEVSETDRRIADRIMKSVGLTV................................................................................................................................................... 149
37 -12.900d4e12a1 c.2.1.0 (A:1-189) automated matches {Acinetobacter baylyi [TaxId: 202950]}  ali model 3D-neighbors follow..  13  4ITNVTVLGTGVLGSQIAFQTAFHGFAVTAYDINTDALDAAKKR-IRYSDDLAQAVKDADLVIEAVPESLDLKRDIYTK---LGELAPAKTIFATNSSTSDLVGYTGRGDKFLALHFANHVWVNNTAEVMGTTKT-----DPEVYQQVVEFASAIGMVPIEL................................................................................................................................................ 184
38 -12.900d1e5qa1 c.2.1.3 (A:2-124,A:392-450) Saccharopine reductase {Fungus (Magnaporthe grisea) [TaxId: 148305]}  ali model 3D-neighbors follow..  17  3.KSVLMLGSGFVTRPTLDVLTDSGIKVTVACRTLESAKKLSAGDVNDDAALDAEVAKHDLVISLIPY-------TFHATVIKSAIRQKKHVVTTSYVSPAM-MELDQAAKDAGITVM------NEIGXYSAMAKLVGVPCAVAVKFVLDGTISDR...................................................................................................................................................... 151
39 -12.800d1z82a1 c.2.1.0 (A:2-166) automated matches {Thermotoga maritima [TaxId: 243274]}  ali model 3D-neighbors follow..  17  3..RFFVLGAGSWGTVFAQMLHENGEEVILWARRKEIVDLINVSHTSRATNDLEEIKKEDILVIAIPVQREHLLRLPVKPSMVLNLSKG---IEIKTG--KRVSEIVEEILGCPYAVLSGPSHAEEVAKKLPTAVTLAGENSKELQKR.............................................................................................................................................................. 154
40 -12.700d1li4a1 c.2.1.4 (A:190-352) S-adenosylhomocystein hydrolase {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  10  25.KVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVT-TMDEACQEGNIFVTTTGCIDIILG------RHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNI--KPQVDRYRLKNGRRIILLAEGRLVNL................................................................................................................................................................. 158
41 -12.700d1bg6a2 c.2.1.6 (A:4-187) N-(1-D-carboxylethyl)-L-norvaline dehydrogenase {Arthrobacter, strain 1c [TaxId: 1663]}  ali model 3D-neighbors follow..  26  2.KTYAVLGLGNGGHAFAAYLALKGQSVLAWDIDAQRIKEIQDRGALLTSDIGLAVKDADVILIVVPAIHHASIA----ANIASYISEGQLII..................................................................................................................................................................................................................... 103
42 -12.600d2rcya1 c.2.1.0 (A:2-156) automated matches {Plasmodium falciparum [TaxId: 36329]}  ali model 3D-neighbors follow..  18  4.IKLGFMGLGQMGSALAHGIANANINLFYYGPSKKNT------TLNYMSSNEELARHCDIIVCAV-KPDIAGSVLNN----IKPYLSSKLLI--SICGGLNIGKLEEMVGSENKIVWVMPNTPCLVGEGSFIYCSNKNVNSTDKKYVNDIFNSCGIIH................................................................................................................................................... 151
43 -12.300d1mx3a1 c.2.1.4 (A:126-318) Transcription corepressor CtbP {Human (Homo sapiens), Ctbp1 [TaxId: 9606]}  ali model 3D-neighbors follow..  19  50.ETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSD-GVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLI--NDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDV........................................................................................................................................................................................ 166
44 -12.200d1f0ya2 c.2.1.6 (A:12-203) Short chain L-3-hydroxyacyl CoA dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  17  4VKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKG-IATSTDAASVVHSTDLVVEAIVENLKVKNELFKR---LDKFAAEHTIFASNTSSTSIANATTRQDRFAGLHFFN-PVP---------KLVEVIKTSQKTFESLVDFSKALGKHPVSCKDT............................................................................................................................................. 191
45 -12.200d1txga2 c.2.1.6 (A:1-180) Glycerol-3- phosphate dehydrogenase {Archaeoglobus fulgidus [TaxId: 2234]}  ali model 3D-neighbors follow..  15  2..IVSILGAGAMGSALSVPLVDNGNEVRIWGTEFDTGVKLNGVEIFWPEQLEKCLENAEVVLLGVS-TDGVLPVM---SRILPYLKDQYIVLDFDNSVLTVPEAVWRLKHDERTVAITGPAIAREVAKRMPTTVVFSSPSESSANKMKEIFET........................................................................................................................................................ 171
46 -12.100d1qp8a1 c.2.1.4 (A:83-263) Putative formate dehydrogenase {Pyrobaculum aerophilum [TaxId: 13773]}  ali model 3D-neighbors follow..  11  43.EKVAVLGLGEIGTRVGKILAALGAQVRGFSRTPKEGP------WRFTNSLEEALREARAAVCALPLNKHTRGLV--KYQHLALMAEDAVFVNVGRAEVLDRDGVLRILKERPQFIFASDV........................................................................................................................................................................................ 154
47 -12.000d1dlja2 c.2.1.6 (A:1-196) UDP-glucose dehydrogenase (UDPGDH) {Streptococcus pyogenes [TaxId: 1314]}  ali model 3D-neighbors follow..  15  2..KIAVAGSGYVGLSLGV-LLSLQNEVTIVDILPSKVDKIKSKQLSIKATLDSKAAYKEAELVIIATPTNYNQHVETVIKEVLSVNSHATLIIKSTIPIGFITEMRQKFQTDRI--IFSP-ESKALYDNLYPSRIIVSCEENDSPKVKADAEKF....................................................................................................................................................... 177
48 -11.300d4j0ea1 c.2.1.0 (A:1-198) automated matches {Nematode (Caenorhabditis elegans) [TaxId: 6239]}  ali model 3D-neighbors follow..  15  11IRNVAIVGSGQMGSGIAQVTASSGFNVMLADVNKKALDRAMKA-IKTCNNVSTAVADADLIIEAAIENIDLKRGIFAQ---IEQSCKKDSILTTNTSSEDVAKGLQDKTRFGGLHFFN-PVP---------KLLEVIRSSDETYATLIKFGTAVGKTTVACKDS............................................................................................................................................. 197
49 -11.100d1sc6a1 c.2.1.4 (A:108-295) Phosphoglycerate dehydrogenase {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  18  45.KKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGN----ATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKE--ISLMKPGSLLINASRGTVVDIPALADALASKHLA-IDVPFTSPLAEFDNVLLTPHIGG...................................................................................................................................................................... 188
50 -10.900d1j4aa1 c.2.1.4 (A:104-300) D-lactate dehydrogenase {Lactobacillus helveticus [TaxId: 1587]}  ali model 3D-neighbors follow..  20  44.QVVGVVGTGHIGQVFMQIMEGFGAKVITYDIFRN--PELEKKGYYVD-SLDDLYKQADVISLHVPDVPANVHMI--NDESIAKMKQDVVIVNVSRGPLVDTDAVIRGLDSGKIFGYAMDV........................................................................................................................................................................................ 158
51 -10.500d1wdka3 c.2.1.6 (A:311-496) Fatty oxidation complex alpha subunit, middle domain {Pseudomonas fragi [TaxId: 296]}  ali model 3D-neighbors follow..  19  4VKQAAVLGAGIMGGGIAYQSASKGTPILMKDINEHGIEQRVDKGRMTPAKMAEVFGNVDLVVEAVVENPKVKQAVLAE---VENHVREDAILASNTSTISISLLAKALKRPEGMHFFN-PVH---------PLVEVIRGSDLAVATTVAYAKKMGKNPIVVND.............................................................................................................................................. 184
52 -10.500d1saya1 c.2.1.4 (A:136-303) L-alanine dehydrogenase {Phormidium lapideum [TaxId: 32060]}  ali model 3D-neighbors follow..  18  33.GKVVILGGGVVGTEAAKMAVGLGAQVQIFDINVERLSYLETLFGSRVELLETAVAEADLLIGAVLVPGRRAPILVPAS-LVEQMRTGSVIVDVAV................................................................................................................................................................................................................. 133
53 -10.200d1yjqa2 c.2.1.6 (A:1-167) Ketopantoate reductase PanE {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  8  2..KITVLGCGALGQLWLTALCKQGHEVQGWLRVPQPYCSVNLVETSLTANDPDFLATSDLLLVTLKAWQVSDAVTLPVTTPILLIHNG---MGTIEELQNIQQPLLMGTTTHAARRDGNVI------IHVANGITHIGPARQQDGDYSYLADILQT..................................................................................................................................................... 158
54 -9.910d1pgja1 a.100.1.1 (A:179-478) 6-phosphogluconate dehydrogenase (6PGD) {Trypanosome (Trypanosoma brucei) [TaxId: 5691]}  ali model 3D-neighbors follow..  9  2......................AGSCVMYHNSGEYAILQIWGEVFDILRAMGLNNDEVAAVLEDWKSKNFLKS-------MLDISIAAARAKDKDGSYLTEHVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSFTMYKTERQANASNAPGITPGYTLKNKSPSGPEIKQLYDSVCIAIISCYAQMFQCLREMGLNLPATIATFRAGCIQGYLLKPMTEAFEKNPNISNLMCAFQTEIRDMVALITSKLEVSIPVLSASLNYVTAMFTP---TLKYGQLVSLQRDVFG............... 279
55 -9.830d1ygya1 c.2.1.4 (A:99-282) Phosphoglycerate dehydrogenase {Mycobacterium tuberculosis [TaxId: 1773]}  ali model 3D-neighbors follow..  20  45.KTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSP-ARAAQLGIELL-SLDDLLARADFISVHLPKTPETAGLIDKEA--LAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPCTDSPLFEL.......................................................................................................................................................................... 174
56 -9.560d1l7da1 c.2.1.4 (A:144-326) Nicotinamide nucleotide transhydrogenase dI component {Rhodospirillum rubrum [TaxId: 1085]}  ali model 3D-neighbors follow..  21  30.ARVLVFGVGVAGLQAIATAKRLGAVVMATDVRAATKEQVESLGGKFITVDLKELVKTDIAITTALIPGKPAPVLITEE-MVTKMKPGSVIIDLAV................................................................................................................................................................................................................. 152
57 -9.400d1edza1 c.2.1.7 (A:149-319) Methylenetetrahydrofolate dehydrogenase/cyclohydrolase {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  15  30.KKCIVINRSIVGRPLAALLANDGATVYSVDVNNIQKHHVEDLGEYSEDLLKKCSLDSDVVITGVPSENYKFPT--------EYIKEGAVCINFACNFSDDVKEKASLY---------VPMTGKV------TIAMLLRNMLRLVRN............................................................................................................................................................... 165
58 -9.330d1x0va1 c.2.1.0 (A:2-193) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  15  3.KKVCIVGSGNWGSAIAKIVGGNDPRVTMWVFEEDIGGK-LPPNVVAVPDVVQAAEDADILIFVVPH-QFIGKICLKANATGISLIKG---VDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKELMQT........................................................................................................................................................ 182
59 -9.250d1c1da1 c.2.1.7 (A:149-349) Phenylalanine dehydrogenase {Rhodococcus sp., M4 [TaxId: 1831]}  ali model 3D-neighbors follow..  20  28.LTVLVQGLGAVGGSLASLAAEAGAQLLVADTDTERVAHAVALGHTAVALEDVLSTPCDVFAPC------------AMGGVITTEVARTLVVAGAANNVIADEAASDILHARGILYADFVANAG..................................................................................................................................................................................... 142
60 -9.240d1cf2o1 c.2.1.3 (O:1-138,O:304-336) Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) {Methanothermus fervidus [TaxId: 2180]}  ali model 3D-neighbors follow..  13  1MKAVAINGYGTVGKRVADAIAQQDKGYDLYVAIPERVKLFEKAGIEVAGTVDDMLDEADIVIDCTPEG--------------------------------IGAKNLKMYKEKGIKAI---QGGEKHEDIGLSFNSLSNYEESYGKDYTRVVXIVPENVDAVDKYKSINKTNKAMNIL................................................................................................................................ 172
61 -9.210d2i0za1 c.3.1.8 (A:1-192,A:362-420) Flavoprotein BC4706 {Bacillus cereus [TaxId: 1396]}  ali model 3D-neighbors follow..  16  4..DVIVIGGGPSGLMAAIGAAEEGANVLLLDKGNKLGRKLAISGGGRC-NVTNRLPLDEIVKHIPGNGRFLYSAFFENLGVKLKEEDHGRMFPVSNKAQSVVDALLTRLKDLGVKITNTPVET--IEYENGQTKAVILQTGEVLETNHVVIAVGGKSVPQTGSTGDG.......................................................................................................................................... 177
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.