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Query: [C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase, from COG1018

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MIDMKLAILGAGCYRTHAASGITNFSRACEVAEMVGKPEIAMTHSTITMGAELKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKVNEVAKELPKPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDMQPGIIDKFIDDIKPGAIVTHACTIPTTKFYKIFEEKHGDLVTKPETLNVTSYHPGAVPEMKGQVYIAEGYASEEAINTLFELGQKARGNAYRLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLGAPAGFAQMMAKESLEQITALMEKVGIDKMEEHLDPGALLGTADSMNFGASADILPTVFEILEKRKKLast
1 -62.200d3daga1 c.2.1.6 (A:1-242) 5,10-methenyltetrahydromethanopterin hydrogenase, HMD {Methanocaldococcus jannaschii [TaxId: 2190]}  ali model 3D-neighbors follow..  54  1...MKIAILGAGCYRTHAAAGITNFMRACEVAKEVGKPEIALTHSSITYGAELPCFAEEPGLVIDEFDPKEVMEAHLSGNPESIMPKIREVVKAKAKELPKP-----------PKACIHLVHPEDVGLKVTSDDREAVEGADIVITWLPKGNKQPDIIKKFADAIPEGAIVTHACTIPTTKFAKIFK------DLGREDLNITSYHPGCVPEMKGQVYIAEGYASEEAVNKLYEIGKIARGKAFKMP.................................................................................................... 242
2 -34.400d4e12a1 c.2.1.0 (A:1-189) automated matches {Acinetobacter baylyi [TaxId: 202950]}  ali model 3D-neighbors follow..  16  4................................................ITNVTVLGTGVLGSQIAFQTAFHGFAVTAYDINTDALDAAKKRFEGLAAVYEKEVAGAADGAAQKALGG----------IRYSDDLAQAVKDADLVIEAVPESDLKRDIYTKLGELAPAKTIFTNSSTLLPSDLVGYTGRGD-------KFLALHFANHV--WVNNTAEVMGTTKTDPEVYQQVVEFASAIGMVPIELKKEK................................................................................................. 188
3 -33.600d1f0ya2 c.2.1.6 (A:12-203) Short chain L-3-hydroxyacyl CoA dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  12  1.............................................KIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKKFAENPKAGDEFVEKTLST------IATSTDAASVVHSTDLVVEAIVENKVKNELFKRLDKFAAEHTIFSNTSSLQITSIANATTRQD-------RFAGLHFFNPV--PVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCK.................................................................................................... 189
4 -31.300d4j0ea1 c.2.1.0 (A:1-198) automated matches {Nematode (Caenorhabditis elegans) [TaxId: 6239]}  ali model 3D-neighbors follow..  16  7............................................AMQNIRNVAIVGSGQMGSGIAQVTASSGFNVMLADVNKKALDRAMKAISQSVTHLSKKQK--------TDKEKSDFVTLTMSRIKTCNNVSTAVADADLIIEAAIENDLKRGIFAQIEQSCKKDSILTNTSSFLLEDVAKGLQDKT-------RFGGLHFFNPV--PVMKLLEVIRSDDTSDETYATLIKFGTAVGKTTVACK.................................................................................................... 195
5 -31.000d2pv7a2 c.2.1.6 (A:92-243) Prephenate dehydrogenase TyrA {Haemophilus influenzae [TaxId: 727]}  ali model 3D-neighbors follow..  14  1.......................................................................GFKTINSDIHKIVIVGGYGKLGGLFARYLRASG-----------------PISILDREDWAVAESILANADVVIVSVPINLTL-ETIERLKPYLTENMLLADLTSVKREPLAKMLEVHTG---------AVLGLHPMFGADIASMAVVRCDGRFPERYEWLLEQIQIWGAKIYQT..................................................................................................... 152
6 -29.000d1wdka3 c.2.1.6 (A:311-496) Fatty oxidation complex alpha subunit, middle domain {Pseudomonas fragi [TaxId: 296]}  ali model 3D-neighbors follow..  13  3...............................................DVKQAAVLGAGIMGGGIAYQSASKGTPILMKDINEHGIEQGLAEAAKLLVGRVDK-------------GRMTPAKMAEVLNGIRTLSYGDFGNVDLVVEAVVENKVKQAVLAEVENHVREDAILSNTSTISISLLAKALKRPE-------NFVGMHFFNPV--HMMPLVEVIRGEKSSDLAVATTVAYAKKMGKNPIVVN.................................................................................................... 183
7 -26.800d2f1ka2 c.2.1.6 (A:1-165) Prephenate dehydrogenase TyrA {Synechocystis sp. PCC 6803 [TaxId: 1148]}  ali model 3D-neighbors follow..  12  2..................................................................................KIGVVGLGLIGASLAGDLRRRG---HYLIGVSRQQSTCEKAVERQVDEAGQDLSLLQTAKIIFLCTPIQLIL-PTLEKLIPHLSPTAIVTDVASVKTAIAEPASQLWS----------GFIGGHPMAGTAAQGIDLTPTEYTDPEQLACLRSVLEPLGVKIYLC..................................................................................................... 165
8 -25.300d2g5ca2 c.2.1.6 (A:30-200) Prephenate dehydrogenase TyrA {Aquifex aeolicus [TaxId: 63363]}  ali model 3D-neighbors follow..  13  1................................................................................MQNVLIVGVGFMGGSFAKSLRR-SGFKGKIYGYDINPESISKAVDLGIEGTTSIAKVEFSPDFVMLSSPVRTFR-EIAKKLSYILSEDATVTDQGSVKGKLVYDLENILGK---------RFVGGHPIAGTEKSGVELTPTKKTDKKRLKLVKRVWEDVGGVVEYM..................................................................................................... 171
9 -21.400d3fr7a1 c.2.1.0 (A:86-307) automated matches {Oryza sativa [TaxId: 39947]}  ali model 3D-neighbors follow..  11  1.LDFDTSVFNK---EKVSLAGHEEYIVRGGRNLFPLLPEAFKGIKQIGV-----IGWGSQGPAQAQNLRDSLAEAKSDI----------------------------VVKIGLRKGSKSFDEARAAGFGTLGDIWETVSGSDLVLLLISDAAQA-DNYEKIFSHMKPNSILGLSHGFLLGHLQSAGLDF-------PKNISVIAVCPKGMGPSVRRLFAVHQDVDGRATDVALGWSVALGSPFTFATT................................................................................................... 222
10 -19.600d2pv7a1 a.100.1.12 (A:244-371) Prephenate dehydrogenase TyrA {Haemophilus influenzae [TaxId: 727]}  ali model 3D-neighbors follow..  10  1......................................................................................................................................................................................................................................................NATEHDHNMTYIQALRHFSTFANGLHLSKQPINLANLLALSSPIYRLELAMIGRLFAQDALYADIIMDKSENLKQTYDEALTFFENNDRQGFIDAFHKVRD 108
11 -16.900d4ypoa1 c.2.1.0 (A:1-180) automated matches {Mycobacterium tuberculosis [TaxId: 1773]}  ali model 3D-neighbors follow..  9  7.........................................ADLSIIQGRKVGVIGYGSQGHAHSLSLRDSGVQVRV-----------------------------------GLKQGSRSRPKVEEQGLDVDTPAEVAKWADVVMVLAPDTAQAEIFAGDIEPNLKPGDALFFGHGLNVHFGLIKPPADVAVAMVAPKGPGHLVRRQFVDGKGVPCLVAVEQDPRGDGLALALSYAKAIGGTRAGV..................................................................................................... 176
12 -16.200d2gf2a1 c.2.1.0 (A:41-201) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  14  5......................................................IGLGNMGNPMAKNLMKHGYPLIIYDVFPDAC-----------------------------------KEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYNGILKKVKKGSLLIDSSTIDPAVSKELAKEVEK------MGAVFMDA-PVSGGVGAARSLTFMVGGVEDEFAAAQELLGCMGSNVVYCGA................................................................................................... 161
13 -16.200d3g0oa1 c.2.1.0 (A:6-169) automated matches {Salmonella typhimurium [TaxId: 602]}  ali model 3D-neighbors follow..  16  1..DFHVGIVGLG----------------------------------------------SMGMGAARSCLRAGLSTWGADLNPQACA----------------------------------NLLAEGACGAAASAREFAGVVDALVILVVNAAQVRQVLDGVAHLMKPGSAVMVSSTISSADAQEIAAALTA------LNLNMLDA-PVSGGAVKAAQMTVMASGSEAAFTRLKPVLDAVASNVYRI..................................................................................................... 162
14 -16.100d4dlla1 c.2.1.0 (A:29-190) automated matches {Polaromonas sp. [TaxId: 296591]}  ali model 3D-neighbors follow..  11  9......................................................LGTGSMGLPMARRLCEAGYALQV------------------------------------NRTPARAASLAALGATIHEQARAAARDADIVVSMLENGAVVQDVLQGVAAAMKPGSLFLDMASITPREARDHAARLGA------LGIAHLDT-PVSGVGAEQGTLVIMAGGKPADFERSLPLLKVFGRAT........................................................................................................ 159
15 -15.800d5je8a1 c.2.1.0 (A:1-163) automated matches {Bacillus cereus [TaxId: 226900]}  ali model 3D-neighbors follow..  9  1................................................MKKIGFIGLGNMGLPMSKNLVKSGYTVYGVD-----------------------------------LNKEAEASFEKEGGIIGLSISKLAETCDVVFTSLPSPRAVEAVYEGLFENGHSNVVFIDTSTVSPQLNKQLEEAAKE------KKVDFLAA-PVSGIGAENRTLTFMVGGSKDVYEKTESIMGVLGANIFHV..................................................................................................... 161
16 -15.800d3ws7a1 c.2.1.0 (A:1-161) automated matches {Pyrobaculum calidifontis [TaxId: 410359]}  ali model 3D-neighbors follow..  11  1...MRVGFIGLG----------------------------------------------IMGGPMATHLLKAGFLAAV------------------------------------NRTREKTKPFAEAGVYVAESPADLAKRVDVVIVMVSDAPDVEQVLSGVVEGARPGLIVVDMSTNSPDWARKFAERLAQ------YGIEFLDA-PVTGGQKGAIELTIMVGGKEELFHRLLPIFKAMGRDIVYM..................................................................................................... 160
17 -15.800d2f1ka1 a.100.1.12 (A:166-279) Prephenate dehydrogenase TyrA {Synechocystis sp. PCC 6803 [TaxId: 1148]}  ali model 3D-neighbors follow..  14  1......................................................................................................................................................................................................................................................TPADHDQAVAWISHLPVMVSAALIQACAGEKD--GDILKLAQNLASSGFRDTSRVGGGNPLGTMMATYNQRALLQHLDQLITLISNQQWPELHRLLQQTNG 107
18 -15.500d2uyya1 c.2.1.0 (A:262-429) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  9  12......................................................LGLGLMGSGIVSNLLKMGHTVTV------------------------------------NRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVS------RGGRFLEA-PVSGNQQLSNDLVILAAGDRGLYEDCSSCFQAMGKTSFFL..................................................................................................... 166
19 -15.500d2g5ca1 a.100.1.12 (A:201-310) Prephenate dehydrogenase TyrA {Aquifex aeolicus [TaxId: 63363]}  ali model 3D-neighbors follow..  8  1......................................................................................................................................................................................................................................................SPELHDYVFGVVSHLPHAVAFALVDTLIHMSTPEVDLFKYPG----GGFKDFTRIAKSDPMWRDIFLENKENVMKSLNHLKELIVREAEEELVEYLKEVKI 105
20 -15.400d1txga2 c.2.1.6 (A:1-180) Glycerol-3- phosphate dehydrogenase {Archaeoglobus fulgidus [TaxId: 2234]}  ali model 3D-neighbors follow..  14  1...MIVSILGAGAM----------------------------------------------GSALSVPLVDNGNEVRI---------------------GTEFDTEILKSISAGREHPRLGVKLNGVEIFWPEQLEKCLENAEVVLLGVSTDGV-LPVMSRILPYLKDQYIVLISKG-FDNSVLTVPEAVWRLKHDLRERTVAITG-PAIAREVA--TTVVFSSPSESSANKMKEIFETEYFGVEVTT.................................................................................................... 180
21 -14.700d2i76a2 c.2.1.6 (A:2-154) Hypothetical protein TM1727 {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  7  1..................................................................................VLNFVGTGTLTRFFLECLKDRYEIGYI---LSRSIDRARNLAEVYGGKAATLEKHPELNGVVFVIVPDRYI-KTVANHLN---LGDAVLVHCSGFLSSEI---------------KKSGRASIHPNFSFSSLEKQIVFGLEGDERGLPIVKKIAEEISGKYFVIPSEK................................................................................................. 153
22 -14.100d1jaya_ c.2.1.6 (A:) Coenzyme F420H2:NADP+ oxidoreductase (FNO) {Archaeoglobus fulgidus [TaxId: 2234]}  ali model 3D-neighbors follow..  10  1...MRVALLG---------------------------------------------GTGNLGKGLALRLATLGHEIV-------VGSRREEKAEAKAAEYRRIAGDASIT---------------------GMKNEDAAEACDIAVLTIPWEHA-IDTARDLKNILREKIVVSPLVPVSRGAKGFTYSSERSAAEIVASALHTIPAARFANLDEKFDWDVPVCGDDDESKKVVMSLISEIGLRPLDAGPLSNSRLVESLTPL...................................................................................... 194
23 -13.900d4gwga1 c.2.1.0 (A:1-176) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  10  8......................................................IGLAVMGQNLILNMNDHGFVVCAFNRTVSKV------------------------------DDFLANEAKGTKVVGAQSLKEMVSKLKRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKA------KGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKV........................................................................................................ 163
24 -13.300d2cvza2 c.2.1.6 (A:2-157) Hydroxyisobutyrate dehydrogenase {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  12  6......................................................IGLGAMGYPMAGHLARRFPTLVWNRTFEKA-------------------------------------LRHQEEFGSEAVPLERVAEARVIFTCLPTTREVYEVAEALYPYLREGTYWVDATSGEPEASRRLAERLRE------KGVTYLDA-PVSGSGAEAGTLTVMLGGPEEAVERVRPFL-AYAKKVVHVGP................................................................................................... 156
25 -13.300d1bg6a2 c.2.1.6 (A:4-187) N-(1-D-carboxylethyl)-L-norvaline dehydrogenase {Arthrobacter, strain 1c [TaxId: 1663]}  ali model 3D-neighbors follow..  18  1..SKTYAVLG----------------------------------------------LGNGGHAFAAYLALKGQSVLAWDIDAQ-----------RIKEIQDRGAIIAEGPGLAGTAHPDL---------LTSDIGLAVKDADVILIVVP-AIHHASIAANIASYISEGQLIILNPG........................................................................................................................................................................... 107
26 -13.100d1mv8a2 c.2.1.6 (A:1-202) GDP-mannose 6-dehydrogenase {Pseudomonas aeruginosa [TaxId: 287]}  ali model 3D-neighbors follow..  14  1...MRISIFGLG-----------------------------------------------VGAVCAGCLSARGHEVIGVDVSSTKI---------------DLINQGKSPIVEPGLEALLQQGRQTGRLSGTTDFKKAVLDSDVSFICVGTPGYIETVCREIGFAIREKSTVVVRSTVLPGTVNNVVIPLIEDCSGKKAGVDFVGTNPEFLRESTAIK-TVIGELDKQTGDLLEEIYRELDAPIIRKT.................................................................................................... 202
27 -12.700d2rcya1 c.2.1.0 (A:2-156) automated matches {Plasmodium falciparum [TaxId: 36329]}  ali model 3D-neighbors follow..  9  1MENIKLGFMGLGQM------------------------------------------GSALAHGIANANIIKKENLFYYGPSKK-----------------------------------------NTTLNYMSSNEELARHCDIIVCAVK-PDIAGSVLNNIKPYLSSKLLISICGGLNIGKLEEMVGSENKIVWVMPNTPCLVG--------EGSFIYCSNKNVNSTDKKYVNDIFNSCGIIHEI...................................................................................................... 153
28 -12.100d2izza1 c.2.1.0 (A:1-164) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  17  1...MSVGFIGAG----------------------------------------------QLAFALAKGFTAAGV-----------------------------LAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVK-PHIIPFILDEIGADIEDRHIVV---SCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVV-REGATVYATGTHAQVEDGRLMEQLLSSVGFCTEV...................................................................................................... 162
29 -11.900d1i36a2 c.2.1.6 (A:1-152) Conserved hypothetical protein MTH1747 {Methanobacterium thermoautotrophicum [TaxId: 145262]}  ali model 3D-neighbors follow..  11  1...LRVGFIGFG----------------------------------------------EVAQTLASRLRSRGVEVVTSL-----------------------------------EGRSPSTIERARTVGVTETSEEDVYSCPVVISAVTPGVALGAARRAGRHV---RGIYVDINNISPETVRMASSLIEK-----GGFVDAAIMGSVRRKGADIRIIASGRDAEE------FMKLNRYGLNIEVRGRE.................................................................................................. 151
30 -11.800d2ahra2 c.2.1.6 (A:1-152) Pyrroline-5-carboxylate reductase ProC {Streptococcus pyogenes [TaxId: 1314]}  ali model 3D-neighbors follow..  10  1...MKIGIIGVG----------------------------------------------KMASAIIKGLKQTPHELIISGSSLERSK----------------------------------EIAEQLALPYAMSHQDLIDQVDLVILGI-----KPQLFETVLKPLHFKQPIISMAAISLQRLATFVGQDLPLLRIMPNMNAQIL--------QSSTALTGNALVSQELQARVRDLTDSFGSTFDI...................................................................................................... 150
31 -11.800d3k96a1 c.2.1.0 (A:3-180) automated matches {Coxiella burnetii [TaxId: 227377]}  ali model 3D-neighbors follow..  10  4.................................................HPIAILGAGSWGTALALVLARKGQKV----------------------RLWSYESDHVDEMQAEGVNNRYLPNYPPETLKAYCDLKASLEGVTDILIVVP-SFAFHEVITRMKPLIDAKTRIAWGTKGLAKGSRLLHEVVATELGQVPMAV----SGPSLATEVA--TAVSLASNNSQFSKDLIERLHGQRFRVYKND.................................................................................................... 178
32 -11.400d1mx3a1 c.2.1.4 (A:126-318) Transcription corepressor CtbP {Human (Homo sapiens), Ctbp1 [TaxId: 9606]}  ali model 3D-neighbors follow..  13  3TADSTLCHI---NLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPY------------------------------------LSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLIDFTVKQMRQGAFLVNTARGGLVDEKALAQALKE--RIRGAALDVHESEPFSGPLKDAPNLICTPHAA.......................................................................................................................... 192
33 -11.300d1evya2 c.2.1.6 (A:9-197) Glycerol-3- phosphate dehydrogenase {Trypanosome (Leishmania mexicana) [TaxId: 5665]}  ali model 3D-neighbors follow..  12  1..........................................KDELLYLNKAVVFGSGAFGTALAMVLSKKCREVC----------------------VWHMNEEEVRLVNEKRENVLFLKGVQASNITFTSDVEKAYNGAEIILFVIP-TQFLRGFFEKSGGNLIAYAVLVCTKGIERSTLKFPAEIIGEFLPSPLLSV-------LAGPSFAIEVAVSIASADINVARRLQRIMST............................................................................................................. 179
34 -11.300d1x0va1 c.2.1.0 (A:2-193) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  14  1...............................................ASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPP---------NVVAVPDVVQAAEDADILIFVVP-HQFIGKICDQLKGHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMG-ANIASEVA--CETTIGCKDPAQGQLLKELMQTPNFRITVVQ.................................................................................................... 191
35 -11.200d1l7da1 c.2.1.4 (A:144-326) Nicotinamide nucleotide transhydrogenase dI component {Rhodospirillum rubrum [TaxId: 1085]}  ali model 3D-neighbors follow..  11  1...................AGYRAVIDGAYEFARAFPMMMT-AAGTVPPARVLVFGVGVAGLQAIATAKRLGAVVMATDVRAATKEQVESLGGKFITVDDEAMKT------AETAGGYAKEMGEEFRKKQAEAVLKELVKTDIAITTAPGKPAPVLITEEMVTKMKPGSVIIDLAV........................................................................................................................................................................... 152
36 -11.100d1li4a1 c.2.1.4 (A:190-352) S-adenosylhomocystein hydrolase {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  18  2..........................NLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITE-----------------------------------IDPINALQAAMEGYEVT-TMDEACQEGNIFVTTTGCIDI---ILGRHFEQMKDDAIVCNIGH........................................................................................................................................................................... 112
37 -11.000d3tria1 c.2.1.0 (A:2-162) automated matches {Coxiella burnetii [TaxId: 777]}  ali model 3D-neighbors follow..  11  8......................................................IGGGNMARNIVVGLIANGYDPNRICVTNR-------------------------------SLDKLDFFKEKCGVHTTQDNRQGALNADVVVLAVK-PHQIKMVCEELKDILSETKVISLAVGVTTPLIEKWLGKASRIVRAMPNTPSSVR--------AGATGLFANETVDKDQKNLAESIMRAVGLVIWV...................................................................................................... 160
38 -10.800d1saya1 c.2.1.4 (A:136-303) L-alanine dehydrogenase {Phormidium lapideum [TaxId: 32060]}  ali model 3D-neighbors follow..  12  1...................AGRLSVQFGARFLERQGRGVLLGGVPGVKPGKVVILGGGVVGTEAAKMAVGLGAQVQIFDINVERLSYLETLFGSRVELLYSNSAEI----------------------------ETAVAEADLLIGAVPGRRAPILVPASLVEQMRTGSVIVDVAV........................................................................................................................................................................... 133
39 -10.800d3daga2 a.100.1.11 (A:243-344) 5,10-methenyltetrahydromethanopterin hydrogenase, HMD {Methanocaldococcus jannaschii [TaxId: 2190]}  ali model 3D-neighbors follow..  66  1.......................................................................................................................................................................................................................................................ANLIGPVCDMCSAVTATVYAGLLAYRDAVTKILGAPADFAQMMADEALTQIHNLMKEKGIANMEEALDPAALLGTADSMCFGPLAEILPTALKVLEVHK. 99
40 -10.700d5bsea1 c.2.1.0 (A:3-169) automated matches {Medicago truncatula [TaxId: 3880]}  ali model 3D-neighbors follow..  11  1.........................................IIPIPADSYTLGFIGAGKMAESIAKGAVRSGV-------------------------------SPSRIKTAIHSNPARRTAFESIGITVLSSNDDVVRDSNVVVFSVK-PQLLKDVVLKLKPLLTKDKLLVSVAAIKMKDLQEWAGH--------ERFIRVMPNTAATV-GEAASVMSLGGAATEEDANLISQLFGSIGKIWKA...................................................................................................... 165
41 -10.300d2naca1 c.2.1.4 (A:148-335) Formate dehydrogenase {Pseudomonas sp., strain 101 [TaxId: 306]}  ali model 3D-neighbors follow..  10  1............................ISVAEHVVMMILSLVRNYLPSHEWARKGGWNIADCVSHAYDLEA---------MHVGTVAAGRIGLAVLR---RLAPFDVHLHYTDRHRLPESVEKELNLTWHATREDMYPVCDVVTLNCPLHPETEHMIDETLKLFKRGAYIVNTARGKLCDRDAVARALES--RLAGYAGDVWFPQPA--PWRTMPYNGMTPHIS.......................................................................................................................... 187
42 -10.200d1z82a1 c.2.1.0 (A:2-166) automated matches {Thermotoga maritima [TaxId: 243274]}  ali model 3D-neighbors follow..  17  1..EMRFFVLGAGSW----------------------------------------------GTVFAQMLHENGEEVI----------------------LWARRKEIVDLINVSHTSPYVEESKITVRA---TNDLEEIKKEDILVIAIP-VQYIREHLLRLPV--KPSMVLNLSKGIEIKTGKRVSEIVEEILGCPYAVLS-----PSHAEEVAKKLPTAVTLAGENS-KELQKRISTEYFRVYTC..................................................................................................... 165
43 -9.670d1gdha1 c.2.1.4 (A:101-291) D-glycerate dehydrogenase {Hyphomicrobium methylovorum [TaxId: 84]}  ali model 3D-neighbors follow..  7  5TAEIAMLLL------LGSARRAGEGEKMIRTRSWPGWEPLELVGEKLDNKTLGIYGFGSIGQALAKRAQGFDMDID------------------------------------FDTHRASSSDEASYQATFHDSLDSLLSVSQFFSLNAPSTPETRYFFKATIKSLPQGAIVVNTARGDLVDNELVVAALEA--RLAYAGFDVFAGEPNINEGYYDLPTFLFPHIGSA........................................................................................................................ 191
44 -9.670d1s6ya1 c.2.1.5 (A:4-172) 6-phospho-beta-glucosidase {Bacillus stearothermophilus [TaxId: 1422]}  ali model 3D-neighbors follow..  16  2...LKIATIGGGS----------------------------------------SYTPELVEGLIKRYHELPVGELWLVDIPE---------------------GKEKLEIVGALAKRMVEKAGVPIEIHLTLDRRRALDGADFVTTQFRVGGLEARAKDERIP-LKYGVIGQETNGKGLRTIPVILDIIRDMEELCPDAWLINFTNPA........................................................................................................................................... 149
45 -9.510d3fefa1 c.2.1.0 (A:7-171) automated matches {Bacillus subtilis [TaxId: 1423]}  ali model 3D-neighbors follow..  15  1LDQIKIAYIGGGSQG------------------------------ARSLMSDLSIDERMSG------------TVALYDLDFEAAQKNEVIGNHSGN--------------------------GRWRYEAVSTLKKALSAADIVIISILPGSERCGIYQSVGDTVGPGGIIRGLRAVPI-----FAEIARAIRDYAPESWVINYTNPM........................................................................................................................................... 147
46 -9.380d1mo9a2 c.3.1.5 (A:193-313) NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase {Xanthobacter sp., py2 [TaxId: 35809]}  ali model 3D-neighbors follow..  5  2............................VNAKGVFDHATLVEELDYEPGSTVVVVGGSKTAVEYGCFFNATGRRTVMLVRTEPLKLIKDNETRAYVLDRMKE-QGMEIISGSNVTRIEEDANGRVQAVVAMTPNGEMRIETDFVFLGL....................................................................................................................................................................................................... 120
47 -9.300d3u95a1 c.2.1.0 (A:1-191) automated matches {Thermotoga neapolitana [TaxId: 309803]}  ali model 3D-neighbors follow..  14  1...MKISIVGAGSVRFALQ---------------------------------------VEDIAQTDELSREDTHIYLMDVHERRLNASYILARKYVEELN-----------------------SPVKVVKTESLDEAIEGADFIINTAYPYDPRYHD-QELNMVSTYTYVLSSYPDVKL-----ALEIAEKMKKMAPKAYLMQTANPV........................................................................................................................................... 162
48 -9.060d1u8xx1 c.2.1.5 (X:3-169) Maltose-6`-phosphate glucosidase GlvA {Bacillus subtilis [TaxId: 1423]}  ali model 3D-neighbors follow..  17  3..SFSIVIAGGGSTFT----------------------------------------PGIVLMLLDHLEEFPIRKLKLYDNDKERQDRIAGACDVFIREK------------------------PDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP-LKYGVVGQETCGYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPA........................................................................................................................................... 149
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Wyrwicz LS, Godzik A, Kloczkowski A, Rychlewski L. Support-vector-machine classification of linear functional motifs in proteins. J Mol Model 2006 Aug;12(4):453-61. Epub 2005 Dec 10.