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Query: [C] KOG1257 NADP+-dependent malic enzyme, from COG1018

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITELast
1 -87.200d1pj3a2 c.58.1.3 (A:21-279) Mitochondrial NAD(P)-dependent malic enzyme {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  100  1....................IKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDD................................................................................................................................................................................................................................................................................................................. 259
2 -86.500d1pj3a1 c.2.1.7 (A:280-573) Mitochondrial NAD(P)-dependent malic enzyme {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  100  1.......................................................................................................................................................................................................................................................................................IQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWP........... 294
3 -63.700d1vl6a1 c.2.1.7 (A:155-376) Malate oxidoreductase (malic enzyme) {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  23  1......................................................................................................................................................................................................................................................................................DQQGTAVVVSAAFLNALKLTEKKIEEVKVVVNGIGAAGYNIVKFLLDLGVKNVVAVDRKGILNENDPETCL-----------NEYHLEIARITNPERLSGDLETALEGADFFIGVSRGNILKPEW---IKKMSRKPVIFALANPVPEIDPELAREAGAF---------------IVATGRSDHPNQVNNLLAFPGIMKGAVEKRSK-ITKNMLLSAVEAIARSCEPEP---ERIIPEAFDMK-VHLNVYTAVKGSA.................................................. 222
4 -37.500d1vl6a2 c.58.1.3 (A:1-154) Malate oxidoreductase (malic enzyme) {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  21  2.................................................................................................DALEVH-RFLKGKIRTALPVEKVDRETLSLLYTPGVADVARACAEDPEKTYVYTSRWNTVAVVSDGSAVLGLGNIGPYGAPVMEGKAFLFKAFADID---AFPICLS---------------------------ESEEEKIISIVKSLEPSFGGINLEDIGAPKCFRILQRLSEEIPVFHD.................................................................................................................................................................................................................................................................................................................. 154
5 -9.970d1t2da1 c.2.1.5 (A:1-150) Lactate dehydrogenase {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}  ali model 3D-neighbors follow..  13  2..............................................................................................................................................................................................................................................................................................................PKAKIVLVGSGMIGGVMATLIVQKNLGD----------VVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPGKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNK-IIGLG.......................................................................................................................................... 150
6 -9.820d3nepx1 c.2.1.0 (X:22-163) automated matches {Salinibacter ruber [TaxId: 309807]}  ali model 3D-neighbors follow..  13  1................................................................................................................................................................................................................................................................................................................MKVTVIGAGNVGATVAECVAR---------QDVAKEVVMVDIKDGMPQGKALDMRESSPIHGFDTRVTGTNDYGPTEDSDVCIITAGLPRSPGMIVGGVTEQFVEGSPDSTIIVVANPLDVMTYVAYEASGFPTNRVM.............................................................................................................................................. 140
7 -9.690d2v6ba1 c.2.1.0 (A:22-164) automated matches {Deinococcus radiodurans [TaxId: 1299]}  ali model 3D-neighbors follow..  11  1................................................................................................................................................................................................................................................................................................................MKVGVVGTGFVGSTAAFALVLRGSCSELVLVDRDEDRAQAEAEDIAHAAPVSHGTRVWHGGHSELADAQVVILTAGANQKPGESRLDLLEKNADIFRELVPQITRAAPDAVLLVTSNP---VDLLTDLATQLAPGQPVIGSG.......................................................................................................................................... 139
8 -8.900d4m1qa1 c.2.1.0 (A:3-144) automated matches {Bacillus selenitireducens [TaxId: 439292]}  ali model 3D-neighbors follow..  8  2..............................................................................................................................................................................................................................................................................................................KTSRVVIIGTGAVGSSYAFSMINQNVTDEMVLIDLDKRKTEGDAMDLNHGIPFGAPTKVWAGDYGDCKSADIVVITAGAAQKPGETRLDLVEKNANIFKGIVDQVMGSGFNGIFIIATNPVDVLAYATWKFSGLPKERVI.............................................................................................................................................. 141
9 -8.750d4ajjc1 c.2.1.0 (C:1-159) automated matches {Norway rat (Rattus norvegicus) [TaxId: 10116]}  ali model 3D-neighbors follow..  14  1.............................................................................................................................................................................................................................................................................................AALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILM---------KDLADELALVD----VIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVI.............................................................................................................................................. 158
10 -8.550d1llda1 c.2.1.5 (A:7-149) Lactate dehydrogenase {Bifidobacterium longum, strain am101-2 [TaxId: 216816]}  ali model 3D-neighbors follow..  16  1...............................................................................................................................................................................................................................................................................................................PTKLAVIGAGAVGSTLAFAAAQ---------RGIAREIVLED----IAKERVEAEVLDMQHGSSFYPTVSIDGSDDPEICRDADMVVITAGPRQNILKAIMPNLVKVAPNAIYMLITNPVDIATHVAQKLTGLPENQ-IFGSG.......................................................................................................................................... 143
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 3 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.