current user: public
If you have questions about the server, please let us know.

Query: [R] KOG3518 Putative guanine nucleotide exchange factor, from COG1018

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370    .  380    .  390    .  400    .  410    .  420    .  430    .  440    .  450    .  460    .  470    .  480    .  490    .  500    .  510    .  520    .  530    .  540    .  550    .  560    .  570    .  580    .  590    .  600    .  610    .  620    .  630    .  640    .  650    .  660    .  670    .  680    .  690    .  700    .  710    .  720    .  730    .  740    .  750    .  760    .  770    .  780    .  790    .  800    .  810    .  820    .  830    .  840    .  850    .  860    .
# Score Template Links and tools%idFirst MCAAQAHQHCSTSVAGDRLLGSSTELAPSLLGIYDTLTNSFAAGGVAAAPTATSHESKASSSGDSTPKRSNSNCSSSSSTGSSTGSCSSVPTSDDQSASYTLASSSTHLGHQEPPAPLVVAGLRDEPDGAQLSRLVQRRSQESQIHGSSSSIASSGSSRRGSNIRILSPNVHRIITHSDIQPVEAVSAEALKQHQQQSQRSPTQGRYIKTGHSGTPPAAGSAPKLKLSHIPLSKITGKLSTQSGSELVSTFDSSNEYLNSVAFAAFEKSKPQDEDRTPTNKSVPGTPFHFDGHPFQGRKLTLPRYDSQQSIKLIEMEQLAATSAQLLHAKPATPGTPATPTPSATKAKEFVCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEGECFPLGLast
1 -51.900d1ntya1 a.87.1.1 (A:1231-1414) Triple functional domain protein TRIO {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  27  1.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPNKELIIFGNMQEIYEFHNNFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAG-----SYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCGKGEIKDGLEVMLSVPKRANDAMHL................................................................................................................................................... 181
2 -47.100d1foea1 a.87.1.1 (A:1034-1239) GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) {Mouse (Mus musculus) [TaxId: 10090]}  ali model 3D-neighbors follow..  30  3...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPRQQHSSTLESYLIKPIQRVLKYPLLLRELFALTEHYHLDVAIKTMNKVASHINEMQKIHE................................................................................................................................................. 206
3 -44.800d2dfka1 a.87.1.1 (A:37-239) Rho guanine nucleotide exchange factor 9, Collybistin {Norway rat (Rattus norvegicus) [TaxId: 10116]}  ali model 3D-neighbors follow..  29  6.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQIDIAIDGFLLTPVQKICKYPLQLAELLKYTDYRYVAAALAVMRNVTQQINERKRRLE................................................................................................................................................. 203
4 -43.700d1f5xa_ a.87.1.1 (A:) RhoGEF Vav {Mouse (Mus musculus) [TaxId: 10090]}  ali model 3D-neighbors follow..  25  12................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RLESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQR---LKPQDMETIFVNIEELFSVHTHFLKELKDALAGPTTLYQVFIKYKERFLVYGRYCSQVESASKHLDQVATAREVQMKLEECSQRNNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTEKENLRLALDAMRDLAQCVNEVKR.................................................................................................................................................... 208
5 -43.200d1by1a1 a.87.1.1 (A:2-209) beta-pix {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  23  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPQRVGGCFLNLMPQMKLYLTYCANHPSAVNVLTEHSE--ELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILT.......................................................................................................................................... 204
6 -39.800d4gyva1 a.87.1.0 (A:536-747) automated matches {Mouse (Mus musculus) [TaxId: 10090]}  ali model 3D-neighbors follow..  24  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DEAYFIAKEILATERTYLKDLEVITVWFRSVLIKEEAMPAALMALLFSNIDPVYEFHRGFLHEVEQRLADHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKCKKLEAVYKEFELQKVCYLPLNTFLLKPVQRLVHYRLLLSRLCAHYDYADCHEALKAITEVTTELQQSLTRLENLQKLTELQR....................................................................................................................................... 209
7 -37.700d1dbha1 a.87.1.1 (A:198-404) Son of sevenless-1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  20  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLSANDVENIFSRIVDIHELSVKLLGHIEDTVEPHPLVGSCFEDLAEAFDPYESYARDILRPGFRFLSQLSKPGAALYLQSIGEGFKEQYVLPRLLLAPVYHCLHYFELLKQLEEKSDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESA........................................................................................................................................ 207
8 -33.900d1ki1b1 a.87.1.1 (B:1229-1438) GEF of intersectin {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  18  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKM-KMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDAPDFKEFVKRLEMD--KGMPLSSFILKPMQRVTRYPLIIKNILENTDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQA....................................................................................................................................... 210
9 -27.000d1kz7a2 b.55.1.1 (A:819-965) Dbl`s big sister, Dbs {Mouse (Mus musculus) [TaxId: 10090]}  ali model 3D-neighbors follow..  18  4..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DGNLGDLGKLLMQGSFSVFKPMQRHLFLHEKAVLFCKKREEPSYSYKQSLNMTAVGITENVKGDTKKFEIWY-NAREEVYIIQAPTPEIKAAWVNAIRKVLTSQLQA-CREASQHRALEQSH....... 147
10 -26.700d1txda1 a.87.1.1 (A:766-999) Rho guanine nucleotide exchange factor 12 {Human (Homo sapiens), gamma isoform [TaxId: 9606]}  ali model 3D-neighbors follow..  20  14.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKRNEQIGEDLLTWEKLKHAAATFCSNQPFALEMIKSRQKDSRFQTFVQDAESN--RRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEREKVKKAADHCRQILNFVNQAVKEAENKQRLEDYQRRLD.................................................................................................................................... 230
11 -26.700d1ntya2 b.55.1.1 (A:1415-1535) Triple functional domain protein TRIO {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  25  4..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DENIESQGELILQESFQVRKGRERHLFLFEMSLVFSKEVKDSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTNKIVLKASSIENKQDWIKHIREVIQER......................... 120
12 -21.900d1fhoa_ b.55.1.1 (A:) UNC-89 {Nematode (Caenorhabditis elegans) [TaxId: 6239]}  ali model 3D-neighbors follow..  14  2...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GDTGKLGRIIRHDAFQVWPPKLRYVFLFRNKIMFTEQDASPSYTHYSSIRLDKYNIRQHTTDED-TIVLQPQEPGLPSFRIKPTSEYVRKAWLRDIAEEQEKY......................... 114
13 -18.200d1dbha2 b.55.1.1 (A:418-550) Son of sevenless-1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  15  3....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KKMNEIQKNIDGWEGKDIQCCNEFIMEGTLTRGAKHERHIFLFDGLMICCKSNSNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYR.......................... 130
14 -18.100d1v61a1 b.55.1.1 (A:8-126) Rac/CDC42 GEF 6, alpha-pix {Mouse (Mus musculus) [TaxId: 10090]}  ali model 3D-neighbors follow..  16  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QILSEPIQAWEGDDIKTLGNVIFMSQVVMQHKEERYFLLFSSVLIMLSASRMSGFMYQGKIPIAGMVVNRLDEIEGSDCMFEITGSTVERIVVHCNNNQDFQEWMEQLNRLT............................ 118
15 -18.000d2dfka2 b.55.1.1 (A:240-401) Rho guanine nucleotide exchange factor 9, Collybistin {Norway rat (Rattus norvegicus) [TaxId: 10116]}  ali model 3D-neighbors follow..  15  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NIDKIAQWQASVLDWEGDDILDRSELIYTGEMAWGRNQQRVFFLFDHQMVLCKKDRRDILYYKGRIDMDKYEVIDIEDGRDDDFKL-HNKETEEVHLFFAKKLEEKIRWLRAFREERKMGFEISENQKRQAAMTVRKASK..... 162
16 -17.200d5d3xa1 b.55.1.0 (A:245-406) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  17  1.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EKLEALEQLQSHIEGWEGSNLTDICQLLLQGTLLKISAQERAFFLFDNLLVYCKRKNGSLYIFRGRINTEVMEVENVEDGTADYWKI-HNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMER................ 159
17 -13.000d1ki1b2 b.55.1.1 (B:1439-1580) GEF of intersectin {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  17  3.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QCEGLSEQLVFNSVTNCLGPRKFLHSGKLYAKNNKELYGFLFNDFLLLTQITKPLQYMYKTPIFLNEVLVKLPTDPSGDEFHI---SHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKR................. 142
18 -12.500d1zc3b_ b.55.1.1 (B:) automated matches {Norway rat (Rattus norvegicus) [TaxId: 10116]}  ali model 3D-neighbors follow..  15  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GQYLVYNGDLVEYEADHMAQLQRVHGFLMNDCLLVATWQRRGMYRYNALYPLDRLAVVNVKDNPPMKFKLL---MFPESRIFQAENAKIKREWLEVLEETKRALSD....................... 107
19 -11.300d1txda2 b.55.1.1 (A:1020-1133) Rho guanine nucleotide exchange factor 12 {Human (Homo sapiens), gamma isoform [TaxId: 9606]}  ali model 3D-neighbors follow..  17  1...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MIHEGPLVWKKTIDLYTLLLEDILVLLQKQDDSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAAS.......................... 114
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 6   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Dunbrack RL Jr, Dunker K, Godzik A. Protein structure prediction in biology and medicine. Pac Symp Biocomput. 2000;(12):93-4.