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Query: [M] COG1004 Predicted UDP-glucose 6-dehydrogenase, from COG1018

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKVTVFGIGYVGLVQATVLAEVGHDVLCIDIDANKVADLKKGRIAIFEPGLAPLVKENYEAGRLQFSTDAQAGVAHGVIQFIAVGTPPDEDGAADLKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKVHQVIQAILEQRGEKIDFSVVSNPEFLKEGAAVADCKRPERIVIGIDTDDSGALELISELYEPFNRNHDRMLVMDIRSAELTKYAANGMLATKISFMNEIANIAERLGADIEKVRQGIGSDSRIGYHFIYSGCGYGGSCFPKDIQALIRTAEDKGYKPQLLQAVEQINNQQKYKLTEFIKSHFNSQLAGKTFAVWGLAFKPNTDDMREAPSRVVMESLWEAGATIQAYDPEAMDETQRIYGARDDLRLMGTKESALQGADALIICTEWQSFRAPDFDMIKSRLKHPVIFDGRNLYDPERLNSRGFTYYGIGRGVSINLSLast
1 -116.000[M] COG1004 Predicted UDP-glucose 6-dehydrogenase  ali follow..  100  1MKVTVFGIGYVGLVQATVLAEVGHDVLCIDIDANKVADLKKGRIAIFEPGLAPLVKENYEAGRLQFSTDAQAGVAHGVIQFIAVGTPPDEDGAADLKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKVHQVIQAILEQRGEKIDFSVVSNPEFLKEGAAVADCKRPERIVIGIDTDDSGALELISELYEPFNRNHDRMLVMDIRSAELTKYAANGMLATKISFMNEIANIAERLGADIEKVRQGIGSDSRIGYHFIYSGCGYGGSCFPKDIQALIRTAEDKGYKPQLLQAVEQINNQQKYKLTEFIKSHFNSQLAGKTFAVWGLAFKPNTDDMREAPSRVVMESLWEAGATIQAYDPEAMDETQRIYGARDDLRLMGTKESALQGADALIICTEWQSFRAPDFDMIKSRLKHPVIFDGRNLYDPERLNSRGFTYYGIGRGVSINLS 448
2 -82.500[M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase  ali follow..  24  16ALIGIVGLGYVGLPLMLRYNAIGFDVLGIDIDDVKVDKLNAGQCYIEHIPQAKIAK--ARASGFEATTDF-SRVSECDALILCVPTPLNKYREPDMSFVINTTDALKPYLRVGQVVSLESTTYPGTTEEELLPRVQE-GGLVVGRDIYLVYSPEREDPGNPNFETRTIPKVIGGHTPQ---CLEVGIALYEQAIDR--VVPVSSTKAAEMTKLLENIHRAVNIGLVNEMKIVADRMGIDIFEVVDAAATKP-FGFTPYYPGPGLGGHCIPIDPFYLTWKAREYGLHTRFIELSGEVNQAMPEYVLGKLMDGLGRALKGSRVLVLGIAYKKNVDDMRESPSVEIMELIEAKGGMVAYSDPHVPVFPKMREHHF-ELSSEPLTAENLARFDAVVLATDHDKFDYELI-----KAEAKLVVDSRGKYRSPAAHII................ 434
3 -18.400[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  17  3.TIGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLADLVAKGL--------------------KTVSGHAAVAKAADIIITMVPDT------PQVADVLFGDNGVASGLTRGKLVIDMSSISPIETKVFAGKINELGCDY---LDAPVSGGEVGAKAASLT--------MVGGEEKAFERAKPVFEKMGKNI------TLVGPNGVGQTTKVANQIVVALTIEAVAEALVFASKAGADPARVRQALMGGLAASRILEVHGPGFRIELHQKDLNLALEGAKALGVSLPNTSTTQQLAREDHSALVRALERMANFEVGGAV................................................................................................................................ 297
4 -14.800[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  13  1MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDRTTGVASLRELS----------------QRLSAPRVVWVMVPAG---------NITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHL---LDCGTSGGVWGRERGYCL--------MIGGDGDAFARAEPIFATV-EVAPSEQGYLHCGPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAP..................................................................................................................................................................................................... 229
5 -14.600[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  12  3ADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKV---------------DHFLANEAKGKSIIGATSIEDFISKLKRPRKVMLLV------KAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKGILF---VGSGVSGGEEGARYGPSL--------MPGGSEEAWPHIKNIFQSISAKSDGEPCCEWVGPAGAGHYVKMVHNGIEYGDMQLICEAYDIMKRLGGFTDKEIS--------------------------DVFAKWNNGVLDSFLVEITRDILKFDDVDGKPLVEKIMDTAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSALKNERIRASK---VLPGPEVPKDAVKDREQFVDDLEQALYASKIISYAQGFMLIRKLNNPAIALMWRGGCIIRSV........................... 370
6 -14.500[G] COG0362 6-phosphogluconate dehydrogenase  ali follow..  11  5GDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKV---------------DEFLQGAAKGTNIIGAYSLEDLAAKLEKPRKVMLMV------RAGDVVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAEKGIRF---IGSGVSGGEEGARHGPSI--------MPGGNQEAWQYVKPIFQAISAKTEQGEPCCDWVGGEGAHFVKMVHNGIEYGDMQLICEAYQFLKEGLGLSYEEMQAI--------------------------FAEWKNTELDSYLIDITTDILGYKDASGEPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVDQRVAANQLFGKTITPVEGDKKVWIEAVRKALLASKIISYAQGFMLIREASEQFGW-DINYGATALLWREGCIIRSR........................... 371
7 -12.900[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  14  4.HIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERRHPLAPNVV--------SPNLSFTTDMKEAIHNAFMIVEGVTS----------AGIRPVAEQLKQITDLSVPFVITSKGIEQNTGLLLSEIMLEVLGDSVTPYLGYLSGPSIAKE--------SPCSVVVS--AYDSQTLKQIHEAFSALGGALKNVIAIACGIAEGLSFGNNAKAGLVTRGLHEMRKLAAIMDCKPETLNGLAGLGDLC-SRNLRFGHLLAGLTFEQAKAKIGMVVEGAYTALSAYQVAKHHKIDMP--ITTGIYRVLYENLDLKE-GIALLLQRNTKEEF................................................................................................................. 333
8 -12.500[S] COG4408 Uncharacterized protein conserved in bacteria  ali follow..  10  3.KLLMIGTGPVAIQLANICYLKSDYEIDMVGRASTSEKSKRLYQAYKKEKQFEVKIQNEAHQHLRLYKDVKNVKGEYETVVMACTA----------DAYYDTLQQLSLETLQSVKHVILISPTFGSQMIVEQFMSKFSQDIEV-STYLGDTRIVDKEAPNHVLTTGVKKKLYMGSTHSNSTMCQRISALAEQLLEVVESPLHAETRNSSLYVHPPLFMNDFSLKITMTLIREMRLMWKEMMAILQAFRVPSVNLLQFMV-------ENYPVRPETLDEGDIEHFEILPDILQEYLLYVR---YTAILIDPFSQPDENGHYFDFSAVPFKQVYKNSEDYYRTAMIQHI---GKMLGIKTPMIDQ..................................................................................... 385
9 -12.000[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  13  4MKVAVYGAG-EAPYGGSRMAEAGHDVVLAEPARDM---------------LDDAHWKVVEDAGVTVTDNDAEAASEAEIAVLFTPFG---------KKTFEIAKNITNHLPEGAVIANTCTVSPVVLYYVLERELRRDRK--------ASMHPAAVPGTPQHGHYVIGGHSSSELDIATDEQISRCVELAESC---GKVAYVVPADVSSAVADMGSLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQ......................................................................................................................................................................................................... 239
10 -12.000[H] COG1893 Ketopantoate reductase  ali follow..  12  4PRVAVIGSGSIGLLLYAYLKLANWPALLVTNRPEQADHLNKEGLTFVAKSGEHQPIS------VTATPLSSFSAEEAEVGFITVKS-----------AVKALLPQLQRKKWDGLVFFQNG---MTHLEILRQIPARAICCGIVEIGAKRESDVRVQHTGDG--------AIWIGDMVGDSKNFDPMWACLHN--AGLKAQKVTNWQDKMERKLIANA--------INPLTGLFRVKNGALIENQLFSLLLKEL-----------------KEACVTLGREREVDEHLAYTRAICDKTANNLSSMYMDLTHHRRTEIESITGYLIKEAAKKGIEIPNTSFVYHAVMGMDEEGRKVR............................................................................................. 306
11 -11.800[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  10  53LRIAIIGFGNYGQFLAETLISQGHILFAHSRS--------------------DHSSAARRLGVSYFTDLHDLCERHPDVVLLCTS----------ILSIENILKTLPQRLRRNTLFVDVLSVKEFAKTLLLQYLPEDFD---------LCTHPMFGPQSVSSNHGWRGLRFVY-RIGEERLRVSRCESFLEIFVREGCEMVEMSVTDHDKF-----------AAESQFITHTLGRL------LGMLKLISTPINTKGYEALLDLAENICGDSFDLYYGLFVYNNNSLEVLERIDLAFEALRKELFSRLHGVVRKQSFELKIGIVGFGNFGQF----------LGKTMVKQGHTVLAYS---RSDYTDEAAKLGVSYFSDLDDLFEEHPEVIILCTSILSTEKVLESLPFQRLKSTLFVDVLSV......................... 457
12 -10.600[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  11  4MKLAILGAG-DEVVVADPVFDNQFTVIDDFAYEDVIEKVNEVAKELPKPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKG---------DMQPGIIDKFIDDIKPGAIVTHACTIPTTKFYKIFEEKHGDLVTKPETLNV-TSYHPGAVPEMKGQV--------YIAEGYASEEAINTLFELGQKA--RGNAYRLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLG................................................................................................................................................................................................................... 281
13 -10.500[C] KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase  ali follow..  11  25ISVGIIGSGNWGTAIAKICGENAKKIQHEGKECNLTEVFNTTHE-------VKYLKGIKCPSNVFANPDIRDVGSRSDILVWVLPH----------QFVVRICNQLKGCLKKDAVAI--SCIKGVSVTKDRVRLFSDIIEENTGMYCGVLSGANIASE--------KFCETTIGYLPNSSVNPRYTPKTIQALFNRPYVNIVEDVPGVALGGALKN-IVAVAAGIINTKSAVMRIGLLEMQKFGRMFFDCKPLTMSEESCGIA--------DLITTCLGGRNHKCAVAFVKTGKPMH-------VVEQELLDGQKLQGAATAKEVYEFLDNQNKVSEFPLFTAVYRIVYEGLPPN............................................................................................. 367
14 -10.200[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali follow..  14  24.NVTIIGAGLMGSGIAQVSANAKLNVTVVDSNQSALEKAQQGIANSLKRVAKKKHADDAAADRIKMSTNVSDSVKDADLVIEAI--------VENIDIKRKLFAEVEVAAKPTTLI---------------------------------TTNTSSLRLADIGLNLKDKSRFG-GLHFFNPVPMMKLLEVVRHTETSDATFNQLVDYGKTVGKTTTPGFIVNRLPYMFEALRLYERGDASMEDIDVAMGAGYPMGPFELSDYVGL........................................................................................................................................................................................ 262
15 -10.200[E] COG0287 Prephenate dehydrogenase  ali follow..  11  9.RIALIGIGLIGSSIARDVRELGRHVVISTRSEDTLKRAEELAL--------------------DYTVSAAEAVKDADLVIVSVP----------VGASESVAQQIAPYLKPSAIVTDVGSTKASVIAQMAPHMPENVH--------FIPGHPLAGTEKSGPDAFRERWCIFTPLPGTDAAALERLKDFWRAL--GSRVDEMDAEHHDKVLAIVSHLPHIIAYNIVGTADDLETVTESEVIKYSASGFRDTRLA----ASDPTMWRDVCLHNKDAILEMLARFSEDLASLQRAIRWGEGDKLFELFSRTRSIRRSIIEAGQDVDTPDFGRHALDQKK............................................................................................................... 310
16 -9.350[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  16  4.TVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAINGNLARQVSSGKMSDEDRKRALSLIKGSGDIND-LAQADLVIEAV--------TEDETVKRKIYGQVCPVMRPDAIL---------------------------------ATNTSSLSITRLASATDRPERFM-GIHFMNPVPVMKLVELVRGIATEEETFKAAKEFVAHLDKTVFPAFIVNRIPMINEAIYTLYEGVGTVDAIDTAMGANHPMGPLQLADFIGL........................................................................................................................................................................................ 236
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 4 5   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Flexible structure alignment by chaining aligned fragment pairs allowing twists. Bioinformatics. 2003 Oct;19 Suppl 2:II246-II255.