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Query: [C] COG1150 Heterodisulfide reductase, subunit C, from COG1018

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVEPRDTVIREEDLNPDFLEELSELVEPVFEEEEVLSVQACYQCGTCTGSCPSGRRTSYRTRLIMRKLQLGLVDEVIKSDELWMCTTCYTCYERCPRGVKIVDAVKAARNLAAKKGYMAKAHRMVAMFVIKTGHAVPINDEIREVRKNIGLDEVPPTTHRYEEALEEVQKLVKINEFDKLIGYDWEEGDLVDLast
1 -70.400[C] COG1150 Heterodisulfide reductase, subunit C  ali follow..  100  1MVEPRDTVIREEDLNPDFLEELSELVEPVFEEEEVLSVQACYQCGTCTGSCPSGRRTSYRTRLIMRKLQLGLVDEVIKSDELWMCTTCYTCYERCPRGVKIVDAVKAARNLAAKKGYMAKAHRMVAMFVIKTGHAVPINDEIREVRKNIGLDEVPPTTHRYEEALEEVQKLVKINEFDKLIGYDWEEGDLVD 192
2 -37.200[C] COG0247 Fe-S oxidoreductase  ali follow..  20  245........LEKIDFTDETKESYGAGKIEDFRQSQLLDLYACVECGRCTNMCPATGTGMLSPMDLILRLRDHLTEDVITEEEIWACTTCRNCEDQCPVMNEHVDKIIDLRRYLVTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDDAEIPTVKEMKKEGKEFEYLFWVGSMGSYDNRSQKIAISAKLLN 483
3 -33.700[C] COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit  ali follow..  16  143.............LKTVSPTPAKEWKQSHEDRLKLDGLYECILCACCSTSCPSYWWNGLGPAVLLQAYRWLIDSRLEDPFRLYRCHTIMNCAQACPKGLNPAKAIAEIKKMMVERR............................................................................ 258
4 -33.300[C] KOG3049 Succinate dehydrogenase, Fe-S protein subunit  ali follow..  16  146FYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGLGPAVLMQAYRWERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV...................................................................... 280
5 -25.200[C] COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain  ali follow..  22  307...................................REVLRCIRCGACLNTCPAYRQGSIYPGPIGSVISPILGGYEEFKDLPSACSLCTACNQVCPVKIPLANLLLKHRRHIAESGMNPLAERLSVKAFTL............................................................. 408
6 -23.500[C] COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit  ali follow..  19  369ILDPEKVGEVAVKTAMKLAPIRKSLKKLPDIDEIIELASECTDCGWCQRVCPNS----LPVMDAVKKAADGDLSKLEEMAIEELCYTCGRCEQECERNIPIVSMVTKAGERRVKD............................................................................. 479
7 -19.400[C] COG1146 Ferredoxin  ali follow..  19  1MAEAKNAPLIGKDALGREVRDLSGVDRKEIEWYPTIDYDKCVTCGICFVTCGR---------RVFDFDKKEGKVIVARPYN--CMVACQTCMNLCPTGA............................................................................................. 93
8 -19.100[C] COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB  ali follow..  23  115......................................NNCIGCTKCIQACPVDA--------------IVGATRAMHTVMSDLCTGCNLCVDPCPTHC............................................................................................. 161
9 -18.900[C] KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit  ali follow..  20  114....................................GEERCIACKLCEAICPAQAIT-------IEAEERADGSRRTTRYDI-KCIYCGFCQEACPVDA............................................................................................. 171
10 -18.200[C] COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC  ali follow..  17  375......................................QSCIRCGLCVDACPAG----LLPQQLYWFSRGEEHEKARNHN-LFDCIECGACAYVCPSNIPLVQYYRQEKAEIRALDQESARAAEAKARFEAKQARLAREKLARELRHK............................................ 479
11 -17.500[C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)  ali follow..  22  58....................................GEERCVACNLCAVACPVGCIS-------LQKAETEDGRWYPEFFRI-RCIFCGLCEEACPTTA............................................................................................. 115
12 -17.500[C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit  ali follow..  21  274....................................ISENCTMCNECAFVCPAAIRPILTNEEEMESAPEGFMTREMRGKD--DCTGCNLCAETCPAKDKALVMKPFEEVAAKEN............................................................................. 362
13 -16.800[C] COG0348 Polyferredoxin  ali follow..  22  224......................................QQCDNCMDCYNVCPEPQVLRDPLH-----AKKSESPLVLSKD----CISCGRCIDVCPEKVFIFTTRFNHSVNHSGE............................................................................. 291
14 -16.800[C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit  ali follow..  20  48...................................IDESKCVKCYICWKFCPEPA--------------IYIKEDGFVAIDYDYCKGCGICANECPTKA............................................................................................. 97
15 -16.700[C] COG1145 Ferredoxin  ali follow..  21  284...................................VDTSRCIACGICMLRCPMKAI----------KAKINREPASVDAE---KCLGCGVCVPTCPMEAELPDGMTYVQELLADKGRD.......................................................................... 363
16 -16.000[R] COG1453 Predicted oxidoreductases of the aldo/keto reductase family  ali follow..  19  259...KENLKIASEAYPNSLTEAELQLVSKVEQKYRQIMKVGCTGCQYCMP-CPSGVNIPECFSIYNHLSTFGNAEDA-KPGMASQCVQCGQCLEKCPQHIDIPTILESVAEELEGS............................................................................. 383
17 -15.800[C] COG1035 Coenzyme F420-reducing hydrogenase, beta subunit  ali follow..  25  6................................AEVIDYDVCAACGACEAVCPIGAVTVKKAAGIRDPNDLSLYEKGGGYQ---VCEGCLTCSRVCPVGSQDGGVASGILKSLFKQGKI.......................................................................... 112
18 -15.100[C] COG1726 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA  ali follow..  18  370....................................GERAMVPIGAYERVMPL----DIIPTLLLRDLAAGDTDSA-QALGCLELDDLALCTFVCPGKNEYGPLLRQALDKIEKEG............................................................................ 446
19 -14.800[R] COG2768 Uncharacterized Fe-S center protein  ali follow..  33  202......................................EKCTKCDECVKICPSNA----------------IEDYQINREK---CVKCLGCSEACDYGA............................................................................................. 243
20 -13.600[C] COG1142 Fe-S-cluster-containing hydrogenase components 2  ali follow..  25  50.......................................LCHHCAPCAVVCPVNAITRVDGAVQLNESL---------------CVSCKLCGIACPFGA............................................................................................. 96
21 -13.600[C] COG0437 Fe-S-cluster-containing hydrogenase components 1  ali follow..  17  66.......................................SCNHCDDCTKVCPSGAMHKREDGFVVVDED--------------VCIGCRYCHMACPYGAPQYNAEKGHMTKCVAEGKQPICVESCPLRALEFGPIEELRQKHGTLAAVAPLPR....................................... 173
22 -13.200[C] COG1600 Uncharacterized Fe-S protein  ali follow..  20  179.....................LGELLIDLPLPVDQPVEEGCGKCVACMTICPTGAIVEVDARRCISYLTIELEGAIPEANRIY---GCDDCQLICPWN.............................................................................................. 261
23 -12.900[R] COG3383 Uncharacterized anaerobic dehydrogenase  ali follow..  20  143...................................YDPDQCILCGRCVEAC-----QQVQVNETLSIDWERSQPRVIWDDD--SCVSCGLCATVCPCNA............................................................................................. 205
24 -12.900[C] COG2440 Ferredoxin-like protein  ali follow..  12  1......MTMAVTKLRVEEKLYQNRYLVDPGRPHIKVRPHERPSALALTHICPAKCYELNDKGQVETTSD--------------GCMECGTCRVLCEASGEI........................................................................................... 83
25 -12.900[C] COG1141 Ferredoxin  ali follow..  15  49...................................VDEITCIGCKHCAHVAR----------NTFYIEPDYGRSRVIRQDG--AEEVIQEAIDTCPVDC............................................................................................. 101
26 -12.500[ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases  ali follow..  15  1MSKVEQMQATPARGEPARKTGFDEIYLPFRADQAQREASRCLKCGECEWTCPLHNHIPQWIELVKAGNIDAAVELSHLTNTL-VCPQDRLCEGACTIRDEHGAVIGNIERYISDQGAGPAGL-ACADVLIRNGVAVTVYDRHPEIGLTFGIPSFKLDKSLLARRREIFSAMGIHFELNCEVGKDVSLDSLLE 231
27 -12.000[Y] KOG2439 Nuclear architecture related protein  ali follow..  9  14.....................................ISPALACVKPTQVSGGKKDNVNMNGEYEVSTEPDQLEKVITLSD---CLACSGCITSSEEILSHSVFLKNWGKLSQQQDKVSPQCRLSLAQYYGLTLEAADLCLMNFFQKHFQCKYM...................................... 137
28 -12.000[C] COG1140 Nitrate reductase beta subunit  ali follow..  16  182......................................RLCEHC-ACVATCPSGAIYKREEDGIV----------LIDQDK---CRGWRMCITGCPYKKIYFNWKSGKSEKCIEAGQPTVCSETCVGRIRYLGVLLYDADAIERAASTENEKDL...................................... 292
29 -11.900[C] COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits  ali follow..  17  517..........VEVVNPYNVRKMVDVLRRALNHDGVAVVEDCTLCMECVNACPALIFDG--------------EKVSIDQS---LCVGCAVCAKICPNRA............................................................................................. 616
30 -11.600[C] COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins  ali follow..  15  566....PDAVAQASGAAARAAIPMVKGEVEIEPIVAVTDSDVCGGCEVCIELCPFGAISIEEGHANVNVAL---------------CKGCGTCVAACPSGARTEQIMAQIEAALNEQ............................................................................. 667
31 -10.800[R] COG4624 Iron only hydrogenase large subunit, C-terminal domain  ali follow..  9  14......................................DLPKDNKKCIKIGSPLA---------------------LSLSD---CLACSGCVSADEAGALSEDLSFVLDLSPQTSFVLSPQSKINI.................................................................. 77
32 -10.700[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  13  323.......................................QCIECKCCN-ICGTSENDD----QLLRGYHMYCLTPSMSEEGSWSCHLCLDLL-KEKASIY............................................................................................ 385
33 -10.600[R] COG0727 Predicted Fe-S-cluster oxidoreductase  ali follow..  16  1MISVKNNPIETRLTEREELRDLKNFPDSKFVGIIKELGFRCELCARC---CTKEFNDHLLDSDLEIIKQFYVSGYALKTKPDGSCIRCRIYESRCP................................................................................................ 127
34 -10.400[TZR] KOG1704 FOG: LIM domain  ali follow..  22  201.......................................HHFQCAQCNDVCLKCFHSSSSTFSCCRLSFSSDTPHMSQGDLHWECFCCCVCSKNCGY............................................................................................... 292
35 -10.100[R] KOG4299 PHD Zn-finger protein  ali follow..  19  261...................................YNNDYCSACHGCCETCPNSFHFTIDP---------------IEEKNLWYCNECKH...................................................................................................... 311
36 -9.930[C] COG1034 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)  ali follow..  12  117....QDMTVMTGHSFRRYRFTKRTHRNQDLGPFISHEMNRCIACYRCVRYY-----KDYADGTDLGVYGAHDNVYFRPEDGTLESEFSGNLVEICPTGV............................................................................................. 207
37 -9.630[K] KOG4218 Nuclear hormone receptor betaFTZ-F1  ali follow..  12  1.MSSNSDTGDLQESLKHGLTPIVSQFKMVNYSYDEDLEELCPVCGTCES-CK------------------GFFKRTVQNNKRYTCIECPYCRQKC--------LSVGMKLEAVRADRMRGGRNK.................................................................... 121
38 -9.580[O] COG5533 Ubiquitin C-terminal hydrolase  ali follow..  13  599....................LTDFSAIIDLFQGQYASRLQCQVCEHTSTTYQTFSVLSVPPRVILDCFREFTKCERLGVDEQWSCPKCLK-KQPSTKQLKITRLIINLKRFDNQMNKNNVFVQ..................................................................... 709
39 -9.510[O] KOG1864 Ubiquitin-specific protease  ali follow..  12  190...................KSDTTTWIHEIFQGILTNETRCLSCETVSSKDEDFLDLSIQNTSISHCLRVFSETETLCGDQKYFCETCSS-IKKPPQ------LALHLKRFKFVE............................................................................. 291
40 -9.460[OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger  ali follow..  22  62.......................................KCNNCGHLKKDCPHII--------YCGATDDHYSRHCPKAIQCSKCVQCTLCKERCPS............................................................................................... 138
41 -9.370[S] COG5254 Predicted membrane protein  ali follow..  12  2.......................................KCVECGA-------------EVDSLYTYYGRGTSNIRL--------AQCKNCKQFADKYIELDVVLISMDVILMKPQVY.......................................................................... 59
42 -9.370[S] KOG3134 Predicted membrane protein  ali follow..  12  2.......................................KCVECGA-------------EVDSLYTYYGRGTSNIRL--------AQCKNCKQFADKYIELDVVLISMDVILMKPQVY.......................................................................... 59
43 -9.300[T] KOG3575 FOG: Hormone receptors  ali follow..  13  36........................................CKVCGACLG-CT------------------VFFRRAVVKNLKYKCMACRYCRQKC--------FAVGMHSSAIQRRDLVGPRKI.................................................................... 117
44 -9.230[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  14  154.FHVEGMKTKSGRKIQRPVAYNPNATALKRKSRKVDMVTLCSVCQRCDG-CNSPYHQLHHP----------IDDATVQVDAEWFCMKC........................................................................................................ 243
45 -9.200[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali follow..  14  2............DHQITTASDFTTTSIPSLY-----QLDTLLRCHICK--------------------------DFLKVPVLTPCTFCSLCIRTCPL--EIIQSYTSLRSSLLD.............................................................................. 96
46 -9.200[L] KOG0287 Postreplication repair protein RAD18  ali follow..  14  2............DHQITTASDFTTTSIPSLY-----QLDTLLRCHICK--------------------------DFLKVPVLTPCTFCSLCIRTCPL--EIIQSYTSLRSSLLD.............................................................................. 96
47 -9.190[C] COG1036 Archaeal flavoproteins  ali follow..  17  180...................................IELLKCKGCGICKELCPYNAIKGGPVEVLVRDVDMRNVEIVKGLQGI--------TVLESPEAI............................................................................................. 235
48 -9.120[C] KOG2282 NADH-ubiquinone oxidoreductase, NDUFS1/75 kDa subunit  ali follow..  15  140....QDQSMMFGNDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFA-----SEIAGVDDLGTTGRGNDMQVTYIEKMFMSELSGNIIDICPVGA............................................................................................. 230
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Bourne PE, Allerston CK, Krebs W, Li W, Shindyalov IN, Godzik A.,Friedberg I, Liu T, Wild D, Hwang S, Ghahramani Z, Chen L, Westbrook J. The status of structural genomics defined through the analysis of current targets and structures. Pac Symp Biocomput. 2004;:375-86.