current user: public
If you have questions about the server, please let us know.

Query: [S] COG5427 Uncharacterized membrane protein, from COG1018

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370    .  380    .  390    .  400    .  410    .  420    .  430    .  440    .  450    .  460    .  470    .  480    .  490    .  500    .  510    .  520    .  530    .  540    .  550    .  560    .  570    .  580    .  590    .  600    .  610    .  620    .  630    .  640    .  650    .  660    .  670    .  680    .  690    .  700    .  710    .  720    .  730    .  740    .  750    .  760    .  770    .  780    .  790    .  800    .  810    .  820    .  830    .  840
# Score Template Links and tools%idFirst MEFGVVARWWVFFGVLLVAGLPVASRLLPDAPDRGASVAMPLSLVVVTLATLWVGQVAYGQLVVGGVFVAVLAAAAWLARGGVEIPRKPLLEVVGVFTVAFVFLIVVRAWADGVQPAGGEQFLDFGLLQALDRAGQLPPRDMWFAGERVVYYYGGQLMASIGAHLTDTAPRFAYEPALAGVYAMGCTAAYGLASTIAAGNGGESRPVGVPTAIGGAGVALAVVVLATGVNWLVVAVPAAAAAVVVTRPRRVRAGVLGAFAFGFASNLGPVIRLLAARVDVVRAAVVAAGINADRRPAITPEAFDMWHASRFMETGLNEFPLFAYLNGDLHAHMVSVPVLFVAVAVGVAYYRTPARQRRRRWALLWGGFPVAGAAILTVNTWSLPTVFGVAALAVALADPAPATLLPTGVQRWTRRESAVGQSVQRVLLAVGVAAVGGVLAVVIAWPFVQNVLLAGASNQHLAVLPVPSQAGALVFVHGLFLAAFGAYFVSRVATSVAGWVVAAAAAGAAVAVAVAVGPVVGGVGITAVVLVGPVLGAAWWLRRRNAAGVECVLVAAGAGLVVLVEYVYLADAASYERFNTVFKVYAQVWALWSVAGGVALAGVSERRASTGGLGAVFVVGLVVAASVYGGLAVTTHAANADDASLDALEYAGNAHPGEAAAARWLGDRRRGTRIVAAPGVDPYTWQNPAASLSGVPTVAGWAHAANYHSQAAWEQRVDDIGVVYETTDAASRAAILEKYDVTYVWVGPVERARYEIPDLSADPGIEPVHRTPAVTIYRVTDDELVAPRSGPITVTTTPQAATATAPGAQTARSPARFVTVTSSASTAVTSSQWGTKLRFSLast
1 -223.000[S] COG5427 Uncharacterized membrane protein  ali follow..  100  1MEFGVVARWWVFFGVLLVAGLPVASRLLPDAPDRGASVAMPLSLVVVTLATLWVGQVAYGQLVVGGVFVAVLAAAAWLARGGVEIPRKPLLEVVGVFTVAFVFLIVVRAWADGVQPAGGEQFLDFGLLQALDRAGQLPPRDMWFAGERVVYYYGGQLMASIGAHLTDTAPRFAYEPALAGVYAMGCTAAYGLASTIAAGNGGESRPVGVPTAIGGAGVALAVVVLATGVNWLVVAVPAAAAAVVVTRPRRVRAGVLGAFAFGFASNLGPVIRLLAARVDVVRAAVVAAGINADRRPAITPEAFDMWHASRFMETGLNEFPLFAYLNGDLHAHMVSVPVLFVAVAVGVAYYRTPARQRRRRWALLWGGFPVAGAAILTVNTWSLPTVFGVAALAVALADPAPATLLPTGVQRWTRRESAVGQSVQRVLLAVGVAAVGGVLAVVIAWPFVQNVLLAGASNQHLAVLPVPSQAGALVFVHGLFLAAFGAYFVSRVATSVAGWVVAAAAAGAAVAVAVAVGPVVGGVGITAVVLVGPVLGAAWWLRRRNAAGVECVLVAAGAGLVVLVEYVYLADAASYERFNTVFKVYAQVWALWSVAGGVALAGVSERRASTGGLGAVFVVGLVVAASVYGGLAVTTHAANADDASLDALEYAGNAHPGEAAAARWLGDRRRGTRIVAAPGVDPYTWQNPAASLSGVPTVAGWAHAANYHSQAAWEQRVDDIGVVYETTDAASRAAILEKYDVTYVWVGPVERARYEIPDLSADPGIEPVHRTPAVTIYRVTDDELVAPRSGPITVTTTPQAATATAPGAQTARSPARFVTVTSSASTAVTSSQWGTKLRFS 840
2 -23.700[R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation  ali follow..  8  27..............................................................................................LILICIAVASVSSRLFS-ESIIHEFDPWFNFRASKILVEQGFYN---NWF--DERSWYPLGMVTSGIIFKVINVNIRDVCVLLAPAFSGITAIATYYLARELKSDA----------------------------------------------------CGLLAAAFMG------------------------------------------------IAPGYTSR------VAGSYDNEAIAITLLMSTFALWIKAVKS-------GSSFWGACTGLLYFYMVT--AWGYVFITNMIPLHVFVLLLMGRYTSKLYIAYTTYYVIGTLASMQVPFVGFQPVSTSEHMSALGVFGLLQLFAFYNYVKGLVSSKQFQILIRFALVCLVGLATVVLFALSSTGVIAPWTGRFYSLWDTNYAKIHIPIIASVSFFDLQFLIWLLPVGVYLCFKELRNEHVFIIIYSVLGTYFCG-----------------VMVRLVLTLTPCVCIAAAVAISTLLDTYIYSLLSRVLVISSTAYFLIMFVYHSSWVTSNAYSSPTVVLSTVLNDGSLM-REAYDWLRRNTPYDTKVMS-----WDYGYQIAGMADRITLVD---------NNTWNNTHIATVGKAMSSPEEKAYPILRKHDVDYILIIYGGTLGYSSDDMNKFFTIEEAFTTVHVRLYKVKKPDTLGRDLKQVTLFEEGKRKKLRRPAKTNEIP........................... 749
3 -23.500[O] KOG2292 Oligosaccharyltransferase, STT3 subunit  ali follow..  8  22..............................................................................................AILLIAWLAGFSSRLFA-ESIIHEFDPWFNYRATAYMVQNGWYN---NWF--DERAWYPLGMITSGGIHWLIPVHIRDICVFLAPIFSGLTSISTYLLTKELWSAG----------------------------------------------------AGLFAASFIA------------------------------------------------IVPGYISR------VAGSYDNEGIAIFALQFTYFLWVRSVKT-------GSVFWSAAAALSYFYMVS--AWGYVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILGLLFSMQIPFVGFQPIRTSEHMAALGVFVLLMAVATLRHLQSVLSRNEFRKLFIVGGLLVGVGVFVAVVVLTMLGVVAPWSGRFYSLWDTGYAKIHIPIIASVSFFDLHILVCAFPVGVWYCIKQINDERVFVVLYAISAVYFAG-----------------VMVRLMLTLTPVVCMLAGVAFSGLLDVFLQESNLKSIVILAVLMLLMMFAVHCTWVTSNAYSSPSIVLAFHNSQDGSRNREAYYWLSQNTADDARVMS-----WDYGYQIAGMANRTTLVD---------NNTWNNSHIALVGKAMSSTEEKSYEIMTSLDVDYVLVIFGGVIGYSGDDINKFTYLEEAYTTEHVRIYRVKKPHEFN-----RPSLKTKERTIPPANFISRKNSKRRKGYIRNRPVV----VKGKRTLK.. 774
4 -22.000[S] KOG4587 Predicted membrane protein  ali follow..  8  30..............................................................................................SVVIIGLLVGYINYQHVYTLF----ENDKHFSHLADFEREMAY------RTEMGLYYSYYKTIINA-----HEINTLNRFNLYPEVILAFLPFRAFAKSANWQIELCWQVNRGELRPVESCEGIGNPHYFYITGVFIVAGTVASSIFYLGVLVSDSIFGGFLSVLCFAF----------------------------------------NHGEATRVQTPPLRE----SF----------AFPFIIGHIAILTFVIKYKKSGHSMILLLTSMAVPALL-------FWQFTQFAFFTQICSIFLAFSLDLIPFSTAKTVIHSHIISFLIGFLLLFGNEMMITALYFPSILALGMIIYISPLLSTLGLKIGLSKGLGIEDDAHIFDILRSKFTSFANFHTRLYTCSAEFDFIQYSTIEKLCGTLLIPLALISLVTFVFNFVKNTNLLWRNSEEIGENGEILYNVVQLCCSTVMAFLIM------------RLKLFMTPHLCIVAALFANSKLLGGDRISKTIRVSALVGVIAILFYRGIPNIRQQLNVKG---------EYSNPDQEMLFDWIQHNTKQDAVFA----GTMPVMANVKLTTLRPIVNHPHYE-----HVGIRERTLKVYSMFSKKPIAEVHKIMKEMGVNYFVFNDERRPECVYRGMSRIAPFKIVYANRNYIVLKI............................................................. 683
5 -15.600[S] COG5617 Predicted integral membrane protein  ali follow..  7  8..............................................................................................LTLATISVIEYIPLYLAPSPPALQINGNGHLFKVHKLMTSGWKPWIEDWYAGYPFLRFYLSYLTAGVL-GKVLGSDTKGYAATLMLTSFLGALALHHYLKSTGRE------------------------------------------------------PCISPLIFLLF----------------------------------------WHLTVSYIEGNFPRANAIHLA-----------PLFLLSLYWLRE-----------KRERYLIASALGISIVALTHYSILPLLIITGILILWDDLRTM----------------------TALGNGIKVLGAVIGLTSFWYVPFLFD---------------------------------------------KKWVEFWNISENKALFKSFSLNPTLLKSPFGILLILLLLIFAIFAIKNLVDRKKVILAGLYLYLSLGFYSPTTWLYSFPLLSIVPPYRWFDLEALIIPLLIGESLKRVQRKSMVALVIIPFTVLAFMNVPKINPYPQDLIKICECKKPTLNGWYHEGSPTKAGERRMIYILTYGGNLTPYLKAYAVRF----TPKEINGYEMVLRIGKYKVYKGDTSFFQPVSVIELPFDFVYIKDTKIISGQPNVVVLYIGQPSKEEESMLWKFIKNGGTVIWVPETKEFLGIKAEIRAISNDELRSSLFNVSRFS...................................... 568
6 -14.200[S] COG4906 Predicted membrane protein  ali follow..  6  66LSVALSISVVMLMGIFANFVYPLL--VEKPITLLPILLTFNVVTLGLLAVEQLIGAYLFSHYGDNSGLLLLYFVIALTPLVFLKSKNFNRTFAIWSIAISLMWSTVFGVSWNYIW--GYDINGEYYYANLVLARGI------W-TYDQYNTIASVNILGPVYSLILNMWIVPIFKIIYPLVFSLVPVILLKAYERLLGNKI---------------------------------------------------WAELSVLFF------------------------------------------------------MFFFQFFVSNMALARMMIVEVYLALLAYATI---------RKINPLFLILFLASLAVSHYGTA------LTMFALLTLPLIRVLENEQRISNKLIA---------------------VFWVVTLLWYAYVGGGFQFNN---------------------------LVIIGYQTLLMLKDLFNPQYSQGLELIVAKMTFMREIAKLINLFAQGLISIGVLTVLNRLIRGRKVKHLEFYALSFAFFAYDIAGIVYFSNRMNVNRLYHLTQFFIAPYLLIGFDSVKRIMNNLSKNRHTLKNSVEIAGVFLVVYFIFTSGWTLVIANDPKPPMWLEKVDGPYWSLSEISGGKWIAEYRYDSLKIYSDQYRALLFLGLINQNINEVSFR--------GEEKISNFPKREAYAYLGKTSVREKKILVINQKYLGTIKEFYYLPIYNKSIFEGLWTSNKIYSSQDVAIYKI............................................................. 695
7 -12.400[O] COG4745 Predicted membrane-bound mannosyltransferase  ali follow..  12  14..............................................................................................AAVVAVTAAALLARLWALGWRVAHQDEARVADWTLQYMDLGAW--YRPIIHG-PFLPH-----VNGVVFDVFGAT-DFTMRLVVAVVGGLLPLTAWLYRTRLSDV-----------------------------------------------------EVGALAVLLAAN-------------------------------------------------------PVVLYYSRFMRNDLLLAGFMFTAVGLFVRFLDTHRAR--------LYASAVPFALAFTTKENSLLYPLCWLGALALVTDDRMAVAGATDTSRLAVVRRAAARIRHRAWRAKAALAGSALTAAVIVVSFYA----------------PKPDLYRLFEQPGRAPAVLEAATIGTYHEFADLWASTSTVAHSYVAFLSHDLSVLVACGTVVSVAAVVGYLANRYATETPRPLVSFAF------YWGVFSVLGYPAVVDIAAAWTAVNALVPLAIPAAVGVGAVVRYGRRGAAAGDTAAVRLAVTVLVVSAAGMGAVAAETTYAHPQSPSNPLVQYAQPGGTMQPTIDDIQRTSGLDVLYYGDSNDTADDGLEFSDAGDGTFNVTTGPPSGWHDRLPFP-SQVGANATTVQTAAE-----VPDTPPPVVISVVSEEDDFAALLAAADNSRYLTDGHNTLVIY-VDTTAVPAAQQ................................................... 571
8 -11.800[S] COG4485 Predicted membrane protein  ali follow..  8  1..................................................................................MKSFLKTYRTYFISFIIPVVIMSGVYLSQ-SIYWNSDNSPLDDVALRNILHGNSNLFYT-FTSGLGLNFYLSSYYLGSFLAPLVYFFDLTNMPDAIYLTTLLKFGLIGLSTFFSLNKLFQSIPQILKLALSTS-------------------------------------------------------------------------------------------------------YALMSFTVSQLE--FILIPLIITGLHLLIT---------------KLLLYFTSLSILFIQNYYFGYMTVLFLIFWYLCQISWDFK-----------------TRKSSVLDFIVISFLAGMASLIMTLPTLFDLQTHGEKLTEVSFDTTKYGAIPMIFVGLFPFILTILFFTLKSIKFHVKLIYVIFFAFLIASFYIEALDLF--HRYAWIFSTLLIYTAAEVLKRLKELKVWNFLVSLFLVVAGFLATIYLKSHYSFLTDLNIL-------TLEFLVVYSLLLLAVIKKFISVNLFAILISLFILVEMSLNASSQMDGIAKEWGFA-------RSAYSRDIPAMESFSTYIGNQFTRTEKLQTQTGNDSMKFNYNGISQFSSVRNRSSSSTLDKLGFKSSGTNLNLRYANNSILADSL--FGIQYN-ISDSPIDKYG---------FKDIYQKDNLTLYE.............................................................. 582
9 -10.200[S] COG5305 Predicted membrane protein  ali follow..  13  1...................................................................................................MFSLGNSFLPVPLD-QAIAPDILLQPDVIHNLITEDNHPP-----------YFVLVHLWMKLFPNQGELVSLLAARSFPALLGAVSIPLTYILGRLAFRSSL---------------------------------------------------VGQLAAGMMAVS-------------------------------------------------------PYAVYLGQEVRHYTLAMIWVIASLSCLVIATRHIQN-RTLLPFWLIILWVGINALGIATHYFFTLTLCAEALVLIFLAWQQSTQAKT----------------LVFFSPLWWRIYAVAAGTAVAGLVWLPSILENRYRSSLTAWIQVQGIGLHLINPIFQAFAAWVTMIM----------------LLPIESSQLAVVIASGLVMLIFAIWATPILVRGFKFQLQQPQTSLATQVFIGVVLGAIALFFILVDITRGARYN--FVYFPAVIILVGAS-------LAVYWQTSKKAVMIIWLMGFVSAVTV----------------ICNLGYQKYYRPD--LLVQIIQQNSQVPVLIATT----HKTLVQTGEMMG----IAR----------ELKLSSSQTSTQFQETDPSTSTVSLEK-PFDLWLVNFHAPTAAEVKQCLADTKSLTAVDGYEYKIYHCREKS......................................................... 514
10 -9.100[P] KOG4505 Na+/H+ antiporter  ali follow..  11  6VEISKPHLAYAIIGGFTSLFMLCSLIIKEKLFLGEATMATATGLIFGPYVAKLFVPTSWGNTDYITEELARVLLVVEVFAAGAELPRAYMMLLPVMIFGWLVSTGFMYALIP-----------RLSFLESLAIAACITATDPVLASSIVGKGKFARRVPGHLRNMLLAESGCNDGMAIPFLYLAIYLIIEKPARHAGRD----------------------------------WVCIIILYECTFGCVLGAIIGVIARKMIKFSERRGLMDRESFLVFYFV-------------------------------------LALFCGGIGTIGVDDL---LVSFCAGAAFSWDSWFSKKTEESHVLLNLSFFVYVGAIMPWPQFHMPHMDLSVWRLVVL-----------------------------AICILIARRIPAVLLFKSFVPDIINWREAL--------------FAGHFGPIGVGALYTCLVARAELEVHSTVPEPNDAIENPEIPNWYCIQVMWPVVCFLVLSSIIV................................................................................................................................................................................................................................................................................................................... 426
11 -9.040[K] COG5118 Transcription initiation factor TFIIIB, Bdp1 subunit  ali follow..  8  369.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DGTMAID----EETMVVDRHKNASIENEYKEKVDENPFANLYNYGSYGRGSYTDPWTVE--------------EMIKFYKA---------LSMWGTDFNLISQL-KAKFVNEEKKRPILIELALRSKNFDEYKNIGTVADFNEKLIELQNEHKHHMKEIEEAKNTAKEEDQTAQRLNDANLNKKGSGGIMTNDLK 552
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 2 2   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li Z, Ye Y, Godzik A. Flexible Structural Neighborhood--a database of protein structural similarities and alignments. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D277-80.