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Query: [S] KOG1008 Uncharacterized conserved protein, contains WD40 repeats, from COG1018

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSGNTHGLSWFPHFPDKFVSWGQEIHLYEVRRKDDHSQKSRLPYISVNYLANESRYQYARCVAASYHSDQPIIAVGLADGKVGICNFRDTYDSSWEYTPRQQRMCTCLAWNELDANILAIGHDRHRNDTCITIWDIERGVPKETANFFGVGESANSICWDRNHRTVIAGMSQKMIKLFDLRQSNATCQSIQTKTVQGLSVSPNGNYLCSYVDSVITLWDPRNIKSPLRQIQSSKNHLQIAWCPTRTSLLSSLQRDSSYITLYDIRSVDTDNSGEIYHVKRQISPFPARYQHSGKFSFVNCLSWHSRDFERALLLADALNILDFRLPATLHTAHSNRRKLPLLMQRPLYTPASPTSTAATPTQQQPTSSCSTNSGSSLDFSTPGGSPFNVDLLKPELFELDLVDETRQRALEDYGIKPDNKRFGELHLTPYLRNVWSTLNNVYSEDRLTGLKATLGINLGHTSEALMASSRIESQVLQWPEGINNSNKLICYRSEQRDLALQLCGWAFEQELDRFIDQLYANKEYSRAAMICVFHLKIFHACNILSSAADNMRDPSMYRITVIALSSFNADRCSSTWRNQRSSANMQIHDPHLRAVFSFLTMEKDNFDAVLKEEGVSLSDRMAFACKYLSETKLADYVAQQIQAAIDGGDLNGLLLTGESQDGIDILQSYMDTSFDVQTVALVAINYFRQELFEDKRIQYWIASYLDHLNSWGLWEKRAELDIKIESIRPSSRSSRTVFLSCNFCGKSVSNALLDEPRPRSTTTSTNRLSSCPSCRKPLPRCSLCLLast
1 -206.000[S] KOG1008 Uncharacterized conserved protein, contains WD40 repeats  ali follow..  100  1MSGNTHGLSWFPHFPDKFVSWGQEIHLYEVRRKDDHSQKSRLPYISVNYLANESRYQYARCVAASYHSDQPIIAVGLADGKVGICNFRDTYDSSWEYTPRQQRMCTCLAWNELDANILAIGHDRHRNDTCITIWDIERGVPKETANFFGVGESANSICWDRNHRTVIAGMSQKMIKLFDLRQSNATCQSIQTKTVQGLSVSPNGNYLCSYVDSVITLWDPRNIKSPLRQIQSSKNHLQIAWCPTRTSLLSSLQRDSSYITLYDIRSVDTDNSGEIYHVKRQISPFPARYQHSGKFSFVNCLSWHSRDFERALLLADALNILDFRLPATLHTAHSNRRKLPLLMQRPLYTPASPTSTAATPTQQQPTSSCSTNSGSSLDFSTPGGSPFNVDLLKPELFELDLVDETRQRALEDYGIKPDNKRFGELHLTPYLRNVWSTLNNVYSEDRLTGLKATLGINLGHTSEALMASSRIESQVLQWPEGINNSNKLICYRSEQRDLALQLCGWAFEQELDRFIDQLYANKEYSRAAMICVFHLKIFHACNILSSAADNMRDPSMYRITVIALSSFNADRCSSTWRNQRSSANMQIHDPHLRAVFSFLTMEKDNFDAVLKEEGVSLSDRMAFACKYLSETKLADYVAQQIQAAIDGGDLNGLLLTGESQDGIDILQSYMDTSFDVQTVALVAINYFRQELFEDKRIQYWIASYLDHLNSWGLWEKRAELDIKIESIRPSSRSSRTVFLSCNFCGKSVSNALLDEPRPRSTTTSTNRLSSCPSCRKPLPRCSLCL 785
2 -39.900[T] KOG4378 Nuclear protein COP1  ali follow..  1....MMSNLVEPSWRLLAASGGDTVKLFDVSADSGDPCVLS---------YTPSPGCAVNSVKWNH--TNLVVASTGEDKKISLWRKNGQSLGTVDGGDSAEECLSAISFSKKGSRYICSGGT----GQIVKIWDLQRKLCIKKLK--GHTSTITGVMYNCKDEHLASVSVGGDLIVHNLASGARATEVQFVHVLRLLDYSRSSRHLTAGDDGTVHLWDTTGRSPKMSWLQHSAPTAGVCFSPSNEKIIASVGMDKK-LYTYDSGSRRSSSC-------------------IAYEAPFSSLAFGD-NGYILVAGTSNGRVVFYDIRGKTSLSWQTSKPVIVNEKNYTSEMALLGSTVEDSVVIPDPLPSTTPSASQSAMAPGSRGVSASTVNASSVEQTPNRNHLWHALRANDSYNDDMGVFSPIIDVSSVEFDWKPSSTSKQDDPRAAFSSFGSITPTASSKSEDSASRLAVSSTGASTSGSMFSSSRDFPLSHGQTNFANASLEFPRIRDFSSTFETSSTQTDNNLPSSPLFTKGITAPGNIDSLRLSPNFTRRFSTYAERISTTSSFSDGASLSLGGSPKIKKTGSETREEVLNHLLARPETVVATEAGAMPLMNGGLKQSQT-FTLQLFQRTLEGTLDSFQNS-DVRNL---------IEILRQFHMHEMEMSKV-----------------LSSILENQAEQMKELKLLRKENQ.................................................................. 781
3 -39.300[U] KOG0276 Vesicle coat complex COPI, beta` subunit  ali follow..  11  57.ELPVRSAKFVARK-QWVVAGADDMYIRVYNYNTMDKVK-----------VFEAHSDYIRCVAVHP--TLPYVLSSSDDMLIKLWDWEKGW-ACTQIFEGHSHYVMQVTFNPKDTNTFASASL----DRTIKIWNLGSPDPNFTLD--AHQKGVNCVDYFTGKPYLITGSDDHTAKVWDYQTKSCVTLEGHTHNVSAVCFHPELPIIITGSDGTVRIWHATTYRLENTLNYGLERVWAIGYIKSSRRVVI--GYDEGTIMVKEIQTANIKSIGADYEVTDGERLPLSVKELGTCDLYPQSLKHNP--NGRFVVVCGDGEYIIYTALAWRNRSFGSGLEFVWSSEGECAVRESSSKIKIFSKNFQEKRSIRPTFSAEKIFGGTLLAMCSSDFICFYDWAECRLIQRIDVTVKNLYWADSGDLVAIASDT----------SFYILKFNRDLVTSHFDSGRPTEEEGVEDAFEVLHENDERVRTGIWVGDCFIYNNSSWKLNYCVGG-TTMYHLDRPMYLLGYLASQSRVFLVLVMRGDLDKASEILPTIPKDQHNSVAHFLDALEIATDPDYRFELAIQEIAQEIAVEVQSESKWKQLGELAMSSGKLQ-MAEECMKYAMDLSGLLLLYSSLGDAEG-VTKLATLAKEQGKNNVAFLCLFMLGKLEDCLQLLVESNRIPEAALMARSYLPSKV--SEIVALWRKDYSNLFEDWQV........................................................................ 804
4 -39.100[U] KOG0277 Peroxisomal targeting signal type 2 receptor  ali follow..  11  16.GRHGYAAEFSPYLPGRLACATAQGTLLILDPDEA----------GLRLFRSFDWNDGLFDVTWSEN-NEHVLITCSGDGSLQLWDTAKAAGP-LQVYKEHAQEVYSVDWSQTRGEQLVVSGS---WDQTVKLWDPTVGKSLCTFR--GHESIIYSTIWSPHIPGFASASGDQTLRIWDVKAAGVRIVPAHQAEILSCDWCKYNELVTGAVDCSLRGWDLRNVRQPVFELGHTYAIRRVKFSPFHASVLASCSYDF-TVRFWNFSKPD-----------------SLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYDPACLTIPA..................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 323
5 -38.900[R] KOG1524 WD40 repeat-containing protein CHE-2  ali follow..  14.TEMVCGVGWIGTEA--ILSAADDHVFLLTNTATNESQQ----------ILNMPETFFPTSLHIFPGGQNDVFAVSTSDGKINILS---RNGKVENMVDAHNGAALCARWNS-DGTGLLSSGE----DGFVKMWSRSGMLRS---VLAQFATAVYCVAWDSTSSNVLYCNADHCYIKSLKMQVAPIKWKAHDGIILCCDWNPTSDLIVTGGDLKFKVWDGFG-QILFNSSVHDYPITSISWNTDGTLFAVG---SHNILRLCDKSGWSH-------------------SLEKMNAGSVMALSWSP-DGTQLAVGTAAGLVFHAHIID---------KRLTYEEFEIVQTQKTVIEVRDVSSEVSRETLETKERISKIAILYKYLIVVTSSHIYIYSSKNWNTPTMIEYNERTVNIIVQCEKIFLVSDGMTIT-IFTYEGRKLINLNPPGQVMALLDERKIDLANDTLVVRDRADNKVLHFFDPTTGKAQGDGNLKHEHDIVELTVNQCGPLND--RNVAFRDQIGAVHIAMVKTFGVSQRMVKIGSLVEQLVFNDVTNMLCGI-----SEGKIAVWPLPNVAFHDRNLLQKSLIQKNILANFAGNTIVIRKSDGCLLPTGIL-AIRLCRSIGNDTMWATFAGLAVLHKNMIVMEIAYAALEDDEKVS-LINEIKDKTDKETRQAMQVVLTLERSGLSFRSLMLNIQ-MFKWKVMGYREKYLKNCGQKETDPLHMSEVEIDWVHIRELIAAEKAKGNN............................ 760
6 -38.700[B] KOG0264 Nucleosome remodeling factor, subunit CAF1/NURF55/MSI1  ali follow..  11  123.EGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECN-PDLRLRGHQKEGYGLSWNSN-LSGHLLSASDDHTVCLWDINAGPKDAKAIFTGHSAVVEDVAWHLLHESLFGSVAD----DQKLMIWDTRSNTTSKPSHLVAHTAEVNCLSFNPYSEILATGSADKTVALWDLRNLKLKLHTFHKDEIFQVHWSPHNETISSGTDRRLNVWDLSKIGEEQSA-GHTAKISDFSWNPNEPWVICSVSEDNI-MQIWQMAE----------------------NIYNDEESDVTTSELEGQGS............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 425
7 -37.600[S] KOG0290 Conserved WD40 repeat-containing protein AN11  ali follow..  13  26APWHIYAMNWSVRRDKRLAITQYPNRVEIVQLDESN------GEIRSDPNLSFEHPYPPTKTIFIPDQRPDLLATSSDFLRLWRIADDHSSCLNSNKNSEFCGPLTSFDWNEAEPRRIGTSST----DTTCTIWDIEREAV--DTQLIAHDKEVFDIAWGGVG-VFASVSADGSVRVFDLRDKEHSTSSEPDTPLVRLGWNKQDPRYIIMDSAKVVVLDIRFPALPVVELQHQASVNAIAWAPHSSCHICTAGDDSQ-ALIWDISSMGQHVEGGLDPILA------------TAGAEIEQLQWSSSQPD-WVAIAFSTKLQILRV............................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 346
8 -37.000[S] KOG0270 WD40 repeat-containing protein  ali follow..  12  132.QEEKQELQVYPSD-NLVLAARTELDIYVYDDGAGDIPVEEGDEADPDVARGLVRDPALYCVEWNSEEAANYAAIGTFDPQIEIWNLDKKKSKTGHITTHHTDAVLSMAHNKYFRSVLASTSA----DHTVKLWDLNSGNAARSLASIHSNKNVSSSEWHMLNGSLLTGGYDSRVALTDVRISDESQSAMAGEEIETVTFASENIILCGTDSGNVYSFDIRNNEKPVWTLKHDAGISTLCSNKFIPGMMSTGAMGEKTVKLWKFPLDDATNTKGPSMVL----------SRDFDVGNVLTSSFAPDIEVAMVIGGVNKVLKLWDVFTNRSVRKSFKSE............................................................................................................................................................................................................................................................................................................................................................................................................................................................... 519
9 -36.800[D] KOG0642 Cell-cycle nuclear protein, contains WD-40 repeats  ali follow..  11  463.FDGIRALAFHPIEP-VLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSS--NGEQCYSGGTDGLIQGWNTTNPNSVLRGPLLGHTDAVWGLAYSAAHQRLLSCS-----ADGTLRLWNTTEVAPALSVDIKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTANSSCQINRVISHPTLSISITAHDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSG--SHDCSIRLWNLESKTCIQEFTAHR--------------KKFEESIHDVAFHP-SKCYIASAGADALAKVF.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 779
10 -36.100[R] COG2319 FOG: WD40 repeat  ali follow..  230.IYDVSSVAYSYNG-DILAVGRVDGTLQFWQDNER------------VPRISIHHPGDIGVLAWKPVLETNRLLVGKGNGNIFVYDIISKAVLVATITNAHDEQVCGLTWNH-DGSQFASGG----NDNRVCLFKGSDLR--QPLYVWQQNAAVKALSFCPWQRSLLAGSHDKHIRFYNCFNGKKIDELYCGAQITSIHWSPKYREFSVTVQHRFAVYSWPQLECLVSVLVPDIRCVHSVLTSQLNETTGIIASSNETIKFFDLSEESSWHNSRVLT---------------WHGIFDSQILEMLE-----IDGKIDSHLR................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 535
11 -35.800[DK] KOG0973 Histone transcription regulator HIRA, WD repeat superfamily  ali follow..  8.TGSILAIDCHPSG-KKFITCGSNGLVVVWNAEPVLDKKKASNENVPKLLFQVESQSQSNSCRWSP--DGKRFAFGSDDSSVSVWEYVGLINSMCCVLRGHSMEVLTVEWSP-NGKYLASGS----IDYRIIIYNARKL-PDRITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDSWQCVKSNIEETMLTRLDWSPDGKYLMTPAAPLIKLIQRQTWKSDQFLAGHHKGTTCVRAMPRMQLTCAAVGSRDKSISIWVFPGTLKP------------------LFVINNIFNHTVMDFAW-CGRNLLACSQDGTVKVIHLSESVIGEMISNEAMSDLCYQIYSIRPPRYELTDKEEDESQDSFNLSDLSSSANNASFVTCPEDVLIKRKKLVAAQQSSDIQLTKSMEDNSKENESKNSEKTMMEERNKQIDVRKDGKRRIQPVFCGTTTADPMTSLSSEGKKTVAPPPAKRKALAPAVPAKKGEVDLEDSSDSDDDDEEEEEDMEISDIESVRNKKRKVPATTSQPMLALDLKKPALRPMEPKSLKTQEGTVLMEAPEQQPKKHGGVETTQIKLIKKKQQTAENEDDMMDGERRVNHECLWMAVLGSPVIIVAANKHNVVLGCGDKCLRVY-RTFCGTHIVS-GVTEHAAYALTENGRLSTWNLKLGKAVVTRQPLFCVEASTDNSLISADVSE---TFNVSLSCWIQAITTNVLGRLTSPISDAQLSCSNGTTNSAGPLVRLLKRMRKQATAPGVAPQVVKAVKESQLEQLL-HCAEQL 844
12 -35.700[S] KOG0282 mRNA splicing factor  ali follow..  11  288.TKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLR----------TFIGHSKAVRDICFNT--AGTQFLSAAYDRYLKLWDTETGQ---CISRFTNRKVPYCVKFNPDEDNLFVAGMS----DKKIVQWDIRSGEIVQEYD--RHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVKYIAEPSMHSMPAVTLSPNGKWLACQSDNQILIFGAQNKKKIFKGHMVAGYACQVDFSPDMSYVIS--GDGNGKLNIWDWKTTKLYSRFK------------------AHDKVCIGAVWHPHETSKVITCGWDGLIKLWD............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 579
13 -35.600[S] KOG0308 Conserved WD40 repeat-containing protein  ali follow..  12  29.RSAVSALQYDAQN-GRLFTGGSDTIIRTWSVPHHKDAFSARGGVRSPQGSLEQHTDWVNDMILCG--HGKILISASNDTTVKVWNIERDNKHGIDCIRTHKDYVSCLAYAPIVEKAVSASF-----DHNIFVYDINANF-KTVNNLIGCKDSIYSLATTPNLSLVLGAGTEKCIRLFDPRTNEKIKLRGHTDNVRALVVNDDGTRALSAGDATIRLWDIGQQRCIATCIAHEEGVWTLQVDSSFTTVYS--AGKDKMVVKTPLYDFTKSQL------------------LFKEEAPVKKLLLSEKNPVSLWVGTWKSDIKRWSIRPSAQLSIGGDED--------------------------GPSTSNANHSVSASSSPPVTFKYIRVKDQKGQQSTPELVIPGAPAIKKHAMLSDKRHVLTRDSDGNVA-LYDVLAIFEEVVDENSRQVYIPSWFVVDSKSGMLQITLDELDALSSWLSSKDAGFDDNDRETKQIIVNYGGMMLRSLFERWPPCKMTNVDAADADDLNFISLPEHTPL-IICEGNGRPLYRLLVGDAGKEFEANELAQIAPMW--VIDAIERNQLPKFNKMPFYLLPHPSTNPKQPKK-------DRLS-ATEMLQVKKVMEHVYEKILSTNDVGSIPL------IHTKMEMYDQRLEPDMDLRTV----------------KHLYWKQSYKPV.............................................................................. 682
14 -35.500[R] KOG0302 Ribosome Assembly protein  ali follow..  15  102VKWPFLSFDILQDDNELTVMKLSQLYKTQHDENDDASDNSDVEEDPILEHKSISTKGACNRVRSARSSKESLLASFHETGKVHIWDIAPKENSPLYTVNRHKTEGYALDWSPFEYSLLSGD-----NANEIFLTKYSNGGWQTDSSPFSHTAAVEDLQWSPSEKNVFSSSCDGTFRIWDVRNKQKTVNAHPGVDVNVLSWNTRVPNLTGADNGVWSVWDLRSLKSPVASFKHRAPIYSIEWHPNEDSVIGVVGADNQ-ISLWDLSVELDEEEQDSRAAEGLQDVPPQLMFIHMGQQEIKEMHWHRQIPGTIVSTAMTG................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 471
15 -35.400[DO] KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits  ali follow..  14  126.DFSLNLLDWGSAN---VLAIALGDTVYLWDASSGS---------TSELVTIDEDKGPVTSINWTQ--DGLDLAVGLDNSEVQLWDCVSNR-QVRTLRGGHESRVGSLAWD---NHILTTGG----MDGKIVNNDVRIRSSI-VETYLGHTEEVCGLKWSESGNKQASGGNDNVVHIWDRSLASSKRFEEHTAAVRALAWCPFQASLLATGDGKIKFWNTHT-GACLNSVETGSQVCSLLWSQSERELLSSHGFTQNQLTLWKYPSMSKMAELN------------------GHTSRVLFMAQSP-NGCTVASAAGDENLRLWNVFGEPPKTTKKAASKKYP........................................................................................................................................................................................................................................................................................................................................................................................................................................................... 434
16 -35.200[B] KOG0273 Beta-transducin family (WD-40 repeat) protein  ali follow..  14  179.ESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTLRHCIREGGHDVPSNKDVTSLDWNS--DGTLLAMGSYDGFARIWTENG---NLASTLGQHKGPIFALKWNKKGNYVLSAG-----VDKTTIIWDAHTGEAKQQFP--FHSAPALDVDWQNNMT-FASCSTDMCIHVCRLGCDHPVTFQGHTNEVNAIKWDPSGMLLASCSDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPSIMLASASFDSTVRLWDVEQGVCTHT------------------LMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQSGSEVCWNARGDKVGASAS........................................................................................................................................................................................................................................................................................................................................................................................................................................................ 513
17 -35.200[R] KOG0645 WD40 repeat protein  ali follow..  17  4.TGRLWSVAAHPML-PLFATSSQDKSVRIYNSNTYNLVHVIDG----------FHTRSIRRVAWRPI-ERPVLAVASFDSVVSINEKIDDDWECTAALEGHENEVKCIAWSC-NGNYLATCSR----DKSVWIWEATEDDEFDCLAVLEHTQDVKVVTWHPTEDLLVSGSYDNSICFWRDDGDDTCQLQGHTNTVWALAFSPNGNTLASADDGNVFLWIKISSNEDVATIDHKGAVYTISWMND--ATLCSAGGDGK-IVVYQREKHD-----------EALWHVAYEQDHAHGVYEINSLEYLR--DDRLLSGGDDGECRVWSFK........................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 322
18 -35.100[T] KOG1354 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  11  28.ADIISTVEFNHSG-ELLATGDKGGRVVIFQQEQENKIQSHSREPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISEEASPRRIFANAHTYHINSISINSDYETYLSAD------DLRINLWHLEITDRIKPANMEELTEVITAAEFHPNSCNFVYSSSKGTIRLCDMRASALCFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEDKFECCWNGSDSVVMT--GSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGNKKILHTAWHP--KENIIAVATTNNLYIFQ............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 443
19 -35.000[S] KOG0321 WD40 repeat-containing protein L2DTL  ali follow..  13  127.NQLPFCLGFANNE-SLLAVCTETGALELFDSRFYDRQNEENQPSARRIHGWLAHNNAIFSVNFSK--DDSLLATSSGDQTSKVFDLSTQQCGRRGVDGYHSHSVKQVNFCNDSPYNLVSCSR----DGSIIFWDMRTHGIRKAHENSGRDCSITSATWLPQSTSISSCSANSALKLWDLRTVHTVTTSKRDFGVTNVCTSPDGERIYAASDSIIYEYSSRHLNSGFCRLRISSFYVKLACSPDGATLACGGGDKTSGVVVFDTTRNCSSSAM----------------LTGGHTKDVTAVDWSS--EGQLASISDDGSVRVWNSSLHGSAA..................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 472
20 -34.800[T] KOG0279 G protein beta subunit-like protein  ali follow..  14  15.TDMVTAIATPVDNSDVIVTSSRDKSIILWKLTKEDKS------YGVAQRRMTGHSHFVQDVVLSS--DGQFALSGSWDGELRLWDLATGE--STRRFVGHTKDVLSVAFSTDNRQIVSAS-----RDRTIKLWNTLGECKYTISEADGHKEWVSCVRFSPNTLTIVSASWDKTVKVWNLQNCKLRTLAGHSGYLNTVAVSPDGSLCASGGDGVILLWDLAE-GKKLYSLEAGSIIHSLCFSPNRYWLCAA---TENSIRIWDLESKSVVEDLKVDLKAEAEKT-STGIGNKTKVIYCTSLNWSA-DGNTLFSGYTDGVIRVWGIGR.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 325
21 -34.700[Y] KOG4714 Nucleoporin  ali follow..  13  11ISEKVSQVRWLPEQSERFVTGSWDVRLWRLQSNQYVTATDSEVDQIPRCMDKVRMEDDVTAMEFVD---KDTLAVSCADGHLSVFNVHRAVEGRLHCFQRSQEPAPCTDLSVYGTDIATAG-----EDGCVSIVSVENVRQ--VKRQIEADSMALFSICYISQQELVTANRMGVIRMLDARVATEASQDDKSNFVSSLAKHPMQQHILLCGEGSITVWDMRNLSYPASYLSHKSPINEIGFHQKDPSKLFTAAEGGE-VWMWSENKVLGCDYNKDGHSPSGDRVRSLVDVEGVLSNVRKSINSFDVHGSRLVCGGDTEAVYLVD............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 355
22 -34.500[D] KOG0267 Microtubule severing protein katanin p80 subunit B (contains WD40 repeats)  ali follow..  7.TSPVDSVAFNSEE-VLVLAGASSGVIKLWDLEESKMVR-----------AFTGHRSNCSAVEFHP--FGEFLASGSSDTNLRVWDTRKKG--CIQTYKGHTRGISTIEFSP-DGRWVVSGGL----DNVVKVWDLTAG--KLLHEFKCHEGPIRSLDFHPLEFLLATGSADRTVKFWDLETFELITTRPEATGVRAIAFHPDGQTLFCGLDDGLKVYSWEP-VICRDGVDMGWSTLGDFCINEGK--FIGCSYYRNSVGIWVSDISELEPSVLNDQSERMGSGPRGSVSPDYETREIKNIYVDS-TGGNLNVAQNPGSLKATLPLESGKVA-SDSGEESSYSERESIPFSRTKSGMLLRPAHVRKTLAKFEESKQSAVVQSATRKKSGLAVEEEPQIHRSSNSKYNDTRRAMSADPATFGKGGMENSGDVEDIPSKTERVLSREKPGDEQKNTEYPSGSRELNPVKIVEGVNVVSGRTRSLVEKFERGEKTTHTEGASTTI---RQRRNSAARVRPVLLSQATSHECPVTSVRPLRTSPARVMPTKLNQSVNMTSDTSHIASMHRVSPTQMLATPTVIDQVADMTLDETHATQIQPACEDDSDITENLMLTHNETLQSRL---------TKL-----QIVRHFWERSDVKGAILRKLTDQSVDVISILTEKTLDMFSQLVPVLTSLLGSRTERDMLLKLVAVFGTVIRSTVSAPRIVGVDLHANERNL----------PNLFCGTAQDSKNSSSSRKKRRSNNKKGSRT-----KPSSSRTIAA 969
23 -34.200[A] KOG0291 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  308.DVQLTAANYNTRT-KVLVVAFSSGAFYLYELPDVNMIH-----------SLSISDYPISAALFNCTGD--VALASREIGQLLVWEWQSEQ--YIMKQQGHSSEMTCIAYSS-DGQFIATGGE----DSKVKLWNTQSSFC--FVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFDVNRYRRTFTSPNPAQFSCVAVDYSGELVVAGGQDDIFLWSVKTGKLLEIISGHEGPVVSIAFSPVATSSTLVSGSWDKTVKIWNCLESNSEHE------------------TIDAVSDVTNVTFSP-SGEEIAVATLSGNITIFDIKSAGQVT---------------------------------------------------EGRNDLSAGRLETDIITARKNAQANYFSTIEYSADGECILAAGKSANIC-IYHVREAILLKKFEITQNHSLDGLNDFISRKHLSEFGNMALVEEREELEGGRVAIRLPGVQRGDMSSRRFQ----QEVRVFSVKFSPTGQAFAAAGLCIYALDKGVVFDPF-DLSLEVTPKAVHESLKQQNYTKALVMSLKLNEKDVELVCADLSPEFAQRLLQQLARQLQSTPHI--EFYLQWSCCLLTKHGNQDGVFQHTGLLALHEVLSRKYE-----LNKICDYNKYTL-KVLLDRADKLEQK......................................................................................................... 903
24 -34.000[K] KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA)  ali follow..  13  324.NNNMNCAEFSPDS-TMIACGFQESYIRLWSIKADKKSLPKSTEDSDGSVRLLSHSGPVYGTTFSP--DNKYLLSCSEDASARLWSVDTKTA--LVAYKGHTGPVWDVAFGP-FGHYFATASH----DQTAQLWSCDHIYPLRVFA--GHLSDVDCVTFHPNSAYVLTGSSDKTCRLWDVHRGHSVVFNGHTQPVTAVAIAPDGHTMASADEGLIHLWDIGTGRRIKTMRGHRGNIYSLSFSRE--STVLVSGGSDCTVRAWDVFKTNYNNPVSSSLTGSVVT------PFSAKTSTFNEVNWSTSPDQMVALYTKQTPIFNVSFTRRNLCLAISVS................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 643
25 -34.000[A] KOG0306 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  14  23.KGNIVFVTLRGEK-GRYVAVPACEHVFIWDLRKGEKIL-----------ILQGLKQEVTCLCPSP--DGLHLAVGYEDGSIRIFSLLSGE--GNVTFNGHKAAITTLKYDQ-LGGRLASGS----KDTDIIVWDVINESG--LYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQH-KTMVGHRTEVWGLVLLSEEKRLITGADSELRVWDIAYLQE-SIMREGRDRVVNLAVDKTGR--ILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPVRTTLSFSSDNIAVLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDLSPDQRGFVTGGADKSVK-FWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDC---TVKIFYVDTLKFFLSLYGWGL--DFGDCHKSLFAHDDSVMYLQFVFFTAGKDHKIKQWDADKFEEGHHQEIWCLAVSVVSSSHDKSLRLWERTREPLILEEEREMEREAEQPAVPGETQGDSYFTIETVKAAERIMEAIELYREET-SAYVLEIFKG-IKSSELEESLLVSYVPDILKLFNEFIQLGSDVELICFFLLRIHFGQITSNQMLVPVIEKLRETTIS-KVSQVRDVIGFNMAGLD......................................................... 903
26 -33.900[T] COG5170 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  14  29.ADIISAVEFDHTG-DYLATGDKGGRVVLFERNHSKKGEFQSHEPEFDYLKSLEIEEKINKIRWCKRTNRAHFLLSTNDKTIKLWKLYEKNYPRRVYANAHAYHINSISVNSDAETYISAD------DLRINLWNLSISDHSKPENMEELTEVITSAEFHPINCNLMYSSSKGNIKLLDLRQSAKSFFSEIISSISDVKFSQNGRYILSRDYLTLKIWDVNMEKAPVKTIPLHDDKFECTFSGDDKHVLS--GSYSNNFGIYPTDSSLPGDRGQIVLQAMGSASVGLDPDNLDYNKKILHASWHP--FEDSVAIAATNNLFVFS............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 461
27 -33.800[Z] KOG1523 Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC  ali follow..  11  8.LEPITCHAWNRDR-TQIALSPNNHEVHIYKKNGSQ----------VKAHELKEHNGHITGIDWAP--KSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSP-LENKFAVGSG----ARLISVCYFEAENDVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEEFGGSGTGGWVHGVSFSASGSRLAWVSDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAG---HDCCPMLFIYDDRGSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKRKFCTTGIDGAMTIWDFKT.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 359
28 -33.700[R] KOG4227 WD40 repeat protein  ali follow..  12  53.FGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHS------RVKPIQLKGEHHSNIFCLAFNS--GNTKVFSGGNDEQVILHDVESSETLDVF---AHEDAVYGLSVSPVNDNIFASSSD----DGRVLIWDIRESPHGEPFCLANYPSAFHSVMFNPVEPRLATANSKEGVGLWDIRKPQSSLLNLSLQSAMSVRFNSNGTQLLARRRLPPVLYDIHSRLPVFQFYFNSCTMKSCCFAGDRDQYILS-GSDDFNLYMWRIPADPEAGGIGRVVNGAFM-------VLKGHRSIVNQVRFNPHTY-MICSSGVEKIIKIWSPYK.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 364
29 -33.600[B] KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats)  ali follow..  13  484.GEVVCAVTISNPTR--HVYTGGKGCVKVWDISHPGNK------SPVSQLDCLNRDNYIRSCKLLP--DGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISP-DSKVCFSCCS----DGNIAVWDLHNQTLVRQFQ--GHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMSSNVEVLHVNK-PDKYQLHLHESCVLSLKFAYCGKWFVST--GKDNLLNAWRTPYGASI-------------------FQSKESSSVLSCDISV-DDKYIVTGSGDKKATVYEV............................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 768
30 -33.600[A] KOG0285 Pleiotropic regulator 1  ali follow..  12  118.PGKSTAILPAPGSFNLSTAALMERMPSRWPRPEWHAPWKNYR-------VLQGHLGWVRSVAFDP--SNEWFCTGSADRTIKIWDVATGV--LKLTLTGHIGQVRGLAVSNRHTYMFSAG-----DDKQVKCWDLEQNKVIRSYH--GHLHGVYCLALHPTLDVVLTGGRDSVCRVWDIRTKMQIFVLPHDSDVFSVLARPTDPQVITGSDSTIKFWDLRYGKSMATITNHKKTVRAMALHPKENDFVSVTGGDKGGLWFWDWKSGHNFQRAETIVQPGSL----------ESEAGIYAACYDQ-TGSRLVTCEGDKTIKMWKEDEDAPLNFKPPKEIR............................................................................................................................................................................................................................................................................................................................................................................................................................................................. 475
31 -33.500[S] KOG4328 WD40 protein  ali follow..  12  213VPGRIFVVQFLPCENVKMVAAGDLGNVGFWNLDCGN------EEDNDGIYLFTPHSAPVSSIVFQQN-SLSRVISSSYDGLIRLMDVEKSVFDLVY---STDEAIFSLSQRPNDEQSLYFGQD----YGVFNVWDLRAGKSVFHWE--LHERRINSIDFNPQNPHVMATSSDGTACLWDLRSMGALSTVNHSRAVHSAYFSPSGLSLATTSDNYIGVLSGANFENTCMIYHNNTSKFKAVWGWDDSYIYV--GNLSKKIDVINPKLKRTVMELHNPLQR----------------AIPCRIHCHPYNVGTLAGSTAGGQVYVWTTK........................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 516
32 -33.300[BK] KOG1063 RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily  ali follow..  10  123..TCITAYMVSETD-AMFASASSDGVVNVWDVSFPSQPSEECKVVCLDSICVDTK--AIVTLSLAENPGRFALALGGLDNKIKLYSGERTGKTSVCELKGHTDWIRSLDFSLPNSIMLVSSSQ----DKVIRIWKLVLVGDVGSSVLIGHEDWVYSVEWQPPVIDILSASMDKTMMIWRPEKKTGVELSHCALGFYGGHWSPNSLSILAHGGGAFHLWRNVSSSKESEN-GHFAAVTDVTWARTGEYLLSV--SQDQTTRVFSAWKNDEGNEAEDEHWHELARP-----QVHGHDINCVAMVQGK-GNHRFVSGAEEKVVRVFEAPLSFLKTLNHTCAGGEGSFPEDLQADVQVLGANMSALGLSQKPIYLHSSSEPLERNGGGEGLDTFETVPE------------------------AAPAELKEPPIEDQLAFHTLWPESHKLYGHGNELFSLCSDHKGNLVASSCKAQSASMAEIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTL--------------------LLSVSRDRHFSVFSIQRTDNG--EVSHKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKI-------SVENDARIKQILVLPPFGSSVTAVAWTGLD---------------RNEKSGCVAVGMESGLIELSNVKIIETEEGTTATAALALRLEPFMCHVSAVNAWRPTEKCESNQSLRWLTSCGDD................................................................ 830
33 -33.000[A] KOG0265 U5 snRNP-specific protein-like factor and related proteins  ali follow..  16  55.EGEIFTAEFHPEG-ELLLSSGFDRQIYIWQVYEDCENVM----------AMSGHSGAVMEAHFTP--DGSHIFTCSTDKTLAFWDIATGQ--RQRRFKGHGNFVNSVQGSRRGQQLLCSGSD----DRTIKIWDARKK---HAAHTLESPFQVTAVCFGDTGEQVISGGIDNEVKIWDIRKQAVLHLRGHSDTITGMSLSPEGDFILTNADNTLRVWDVRPYAPGERCVNFEKNLLRCAWSPGSDKITS--GSADRHVYIWDVNTRRILYKLP------------------GHNGSVNAVDFSP-KEPLILSGSSDKTLYLGEIDE.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 347
34 -33.000[S] KOG0772 Uncharacterized conserved protein, contains WD40 repeat  ali follow..  11  123.TQAISALRVEPPG-VRFASGGLDYYVKLFDFQKMDMSMRYDKEL------LPAESHVINSLAFSP--NGETLVVASGEAIIRLLDRAGKQ-IDLNITKGHTATVNCVEFNPLNKNEFISCSD----DGSLRLWNLDDHKVIKTKGANGKRVSPQVCTFSPDGKWIAAGCDDGSVQAWKYGSQNYLVRKAHNGSITSIAFSPDSKRLLSRGDDTLKMWSLDNPKEPLLVLENAFKSTDCGFSPRAEVVFTGTSDTPGTLQFFDPMTFDLVYKID------------------YPGISCHRIQWHP-RLNQIIAGLSDGTIHVYYDQT.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 449
35 -32.900[S] KOG0310 Conserved WD40 repeat-containing protein  ali follow..  26.PAVVSSVRISPKKP-YHVATTSSVRLTLYDTVVCEPLN-----------LFSRFKKGVCSIDFRH--DGRLLAIGGDEGKVRIFDVEKSSKVALRVMQASQSTVKSVHFSPRGDTVFSMA-----DDGKIKQYRVADTNAVPIIEIQAHEDAIRCGAVSSNDHIVLTGGYDHKVRLWDIRSKEKSLELDCEHPVESVLFLPGEQLIATAAGPIVKIWDTTTGRQLTALQAHYKTVTSLRLATNSTCLLS--AGIDRRVNAFRTTNYSLINS--------------------SMPSPVLDIDVSR-DDQTMAIGMGNLLALYRRAEIKKEATASAAIEIRTSAPPVKLVEKDRDMQKVDVVAKNADKLKIPKIDGMLSNFKHAAVIKLLFGGKFRSAMDTAVVSYLRVIVMRGAIHRALAGQ----ERSVQKNILVFLNHNLYKAQYFSTLKEVV-----------------------------------------NAFFDVYA---DKDVVKHVQSLRGSLGRELEVQKMIS--SLIGSIDLIVSTTKMNVKSSSTALI---------EDNDVFGEPTIRARDLDELKP................................................................................................................................................................................................... 531
36 -32.800[S] KOG2106 Uncharacterized conserved protein, contains HELP and WD40 domains  ali follow..  273.NEAVFAADFHPTDTNIIVTCGEI-TSLLLDTRRKLPLI------RSKDYSRTRKAKVVLCVTFSENGD---TITGDSSGNILVWGKGTNR-ISYAVQGAHEGGISPLCMLRDGTLVSGGG-----KDRKLISWSGNYQSGDFTPITQGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAI--GSHDNCIYIYGVSDNGRKYT--------------RVGKCSGHSSFITHLDWSV-NSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI........................................................................................................................................................................................................................................................................................................................................................... 717
37 -32.600[A] KOG0319 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  60.ELRITCTAVDKNR-NRLLVAYNNQIIREYSIPLDPSTTKPELARTW----KTIHTAPILVMEFNE--EGHLLATGSADHIVKVWNLTEQQ---CTHTLKGPSVVSAILFGK-HEKLVVGY-----IEGQLNLYNIMRGAPKKLVNTWSHNSHITALLQVPDSRVVVALSRDQTMSIHETETQETLRVLPLYESIEGGAIGHNGNLFTVGEEGVVKEFVIETAKLVRKKRIASSNLDHLAYDVVSNRFLAI--SAEQNLIILDFENLKIARQIVGFHDEINTKTLDCQLIRGHTESVLSVVSPTW-DTSLLASCSKDNSIIFWRLVTSPENDSCSTLVPVAAATGHALAISNTGRAPFLASVSTDCTIKLWGLGVSTKLKEVKIDAEKDFVEQLPKLTCSSTMVAHGKDVNCVDISESDALIATGGMDKLVK-LWQ----VDTHKMQLGIAGTLSGHRRGVGDVKFAKNSHKLASC------SGDMTIKIWNISEKSCLQTISGHSCAVFRVIFARNDSQLISADSAGIIKIWTIKTADCECSI-DAHTDKIWSLSKNHNESEFVTAGTDGRIVVWKDVTEEKQKAEDNKRREAI-----EQDQTLTNLLSQKR---SEALVFALTLAKPFCAFKVINALMAEETPE---LGSAIRRLDTRQIEILLQFTNTNSRTSSVAQRVLYEIVHIVDPEELVS--MPGAYGYIESFLPYTQR.................................................................... 767
38 -32.500[S] KOG1407 WD40 repeat protein  ali follow..  12  20.KKKVHSVAWNSNG-TKLASGSVDQTARIWNIEPHGH-------SKAKDLELKGHTDSVDQLCWDPK-HSDLVATASGDKSVRLWDARSGK---CTQQVELSGENINITYKP-DGTHVAVGNR----DDELTILDVRKF---KPLHRRKFNYEVNEIAWNMPGDFFFLTTGLGTVEVLSYPSLKPLTLTAHTAGCYCIAIDPKGRYFAVGSDSLVSLWDISDMLCLRTFTKLEWPVRTISFNYS--GEYIASASEDLFIDIANVQTGRTVHQIPCR-------------------AAMNSVEWNP-KYNLLAYAGDDKNPKYNTDEGVFRI...................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 309
39 -32.400[Z] KOG0318 WD40 repeat stress protein/actin interacting protein  ali follow..  11  23.RGQPIVLGADPKGKNFLYTNGNSVIIRNIENPAIADV-------------YTEHSCAVNVAKYSP--SGFYIASGDASGKIRIWDTVNKEHLLKNEFQPIAGPIKDISWSPDNQRIVAVGEGR---ERFGHVFMSETGTSVGEIS--GQSKSINSADFRPARPRIVTGSEDNTIAVFEGPPFKKMTKQDHSRFVQAVRYSPDGKFFASAGDGKVFLYDGTSSEGEFGSPAHKGGVYALAWKPDSTQLLTC--SGDKTCRLWTVESRELVSEF-----------------VMGTTVDDQQVSCLW-QGDNLITVSLSGVITYLNVADPSKPLRVVKGH--------------------------------------------------------------------NKPITVLGLSDDRSTIYTGSHDGVVT-NWN------------------------SGSGTNDRITGTGHGNQINGIAAWGDFVYTCGIDDSLRQFSVEGNSYTDYVVKLNCQPRGLAILRNENIIALACIKELTLVQDQKKIFSLPIKYEASSIAVNAVAVGGDDQKLHIYTLKGGVLEPKVELDHLGAVTDVSYSPDLKYLVACDAHRWGFHSARVNTVAWSPNSLL-----------VASGSLDTTIIIWSVANPAKHTIIKNAHPQSQITRLVWLDNNTVISTGQDCNTKVW..................................................................................... 603
40 -32.200[R] KOG1539 WD repeat protein  ali follow..  146.FTPTSIVHPDTYL-NKVLVGSQEGPLQLWNINTKKMLY-----------QFKGWGSSVTSCVSSP--ALDVVAIGCADGKIHVHNIKLDE-EIVTFEHASRGAVTALSFSTDGRPLLASGGS----FGVISIWNLNKKRLQSVIRD-AHDSSIISLNFLANEPVLMSASADNSLKMWIFDTNDGDFRSGHSAPPLCIRFYSNGRHILSAGDRAFRLFSVIQEQQSRELSQRHISRRAKKLRLKEEGNFAVVGTAGGWIERFNLQSGISRGSYFDMSEKR----------RYAHDGEVIGVACDSTNT-LMISAGYHGDLKVWDFKKRVKIVYHRVNGLATVADDFVIRLYDVVTLKMVREFRGHTDRITDLCFSEDGKWVISSSMDGSLRIWDVILAKQIDGVHVDVPITALSLSPNMDVLATAHSDQNGVYLWV-FSGLPSVESYASGKDVVNVKLPSVSALTSSEADDDMDRQVLENSEALQASSFSISQKQIPELVTLSLLPKSQWQSDIIKARNKPIEPPKKPEKAPFFLPSIPSLSGDILFKANDSEADGENEENNKKDQNSMKNFDALESPFSKHLKSSWDSKHFLDFTNYMKSLSPS--------------ALDMELRMLEIIDIGQLLDYFINEVSCKND-------------FEFMQAVVK----------LFLKIHGETIRCHPSLQEKAKKLLETQSLWQKMEKLFQSTRCIVTFLSN....................................................... 928
41 -32.200[I] KOG0301 Phospholipase A2-activating protein (contains WD40 repeats)  ali follow..  29.KSDTKALAVTQGG--CLISGGRDETVKFWAKKGKQYTKTHA--------FEQPKGITVNSIAYAELADGWRLFVGRRDGTIAVFGPSQAE--PYAIFNEHKQNVCCLHINEKATHMLSGS-----WDSNVIIWPITELNSSTTIVCPGHTLSVWALASFPDPNTYLSASADKTIRMWF-GDTTLSVFKGHTDVVRALVVLSSSHFLSAGNDGHIIHWDVAS-ASILRKFATQAHEFIYSMTLSDSHILTT--GEDGTLEFWAIDGGKDGNLAIVSEAV-----------IQLPTTNTWDAKVLLN--SDIAVAGSDGRIYIMTTDKNCAQEFLSENNLPIHYLEEITRFIKDRIPEARAFDLKSGKKVIVGKGEPDKQMPFNVNESPQFAAQRFVERHQLPVSVIPSLAGMISQEMDKLSKGAASAQSGYEDPFTGPGRYVPQGSSNSGGHGADPFTGSGRYVPQASNSSGFDTGFSGDPLTGDGGYRASAPENTGSHAVPLSIGLAGKGEKAIAKLKELN--EKQDAFQLNPDQINGLEELFVLPTSSNYSSEVTQSAFEMSLQWDRERGQELVGRLIAILVSDPADV-CRCIANAFSHPVGRNLFASTELST----QMSAATALAN-RAILNGIESVDSFGYLGEDAIIRLLQALVT----VMWGDASVIRLAKNRNIAQIAARLKDAVSNDSGKNIARDIVEMTYA........................................................................... 857
42 -32.100[A] KOG0640 mRNA cleavage stimulating factor complex; subunit 1  ali follow..  106.KQACRAGAFSCDG-SLVATGSVDASIKILDVERMLAKSAPEDIEPGREQTLYDHTDEVSYLEFHP--KEHILASASRDGTVKLFDIAKPSVKKAHKVFTDCEPVLCLSFHP-TGDYVAIGTE----HNVLRVYDVATTQCVSAIPSQQHKAGVTCVKYSPTGKLYATGSYDGDIKIWDGISGRCINTIAGGAAICSLEFTRNGKYLLSSGDSLVYLWELCTSRPIQTYTGQEHQTEAVFNHT--EDYVLFPDEATTSLCSWNSRNGCRLTL-----------------NSLGHNGPVRYITHSP-NGPAFLTCSDDFRARFWYRRA.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 421
43 -31.800[R] KOG0286 G-protein beta subunit  ali follow..  17  55.LAKIYAMHWATDS-KLLVSASQDGKLIVWDSYTTNKVH-----------AIPLRSSWVMTCAYAP--SGNFVACGGLDNMCSIYNLKSREGKVSRELSAHTGYLSCCRFLD-DNNIVTSS-----GDTTCALWDIETGQQKTVFV--GHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRTFTGHESDINAICFFPNGEAICTGSDASCRLFDLRADQICFSHESIICGITSVAFSLSGRLLFA--GYDDFNCNVWDSMKSERVGILS------------------GHDNRVSCLGVTA-DGMAVATGSWDSFLKIWN............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 340
44 -31.700[U] KOG1332 Vesicle coat complex COPII, subunit SEC13  ali follow..  12  13.EDMIHDAQMDYYG-TRLATCSSDRSVKIFDVRNGGQILIA---------DLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGILACGSS----DGAISLLTYTGEGQWEVKKINAHTIGCNAVSWAPAVKRFASGGCDNLIKLWKEEEDGQQKLEAHSDWVRDVAWAPSTSTIASCSDGRVFIWTCDDASSNTWSPKFNDVVWHVSWSITAN-ILAVSGGDNK-VTLWKESVDGQWVCISDVN--------------KGQGSVSASVTEGQQNE............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 321
45 -31.300[A] KOG0284 Polyadenylation factor I complex, subunit PFS2  ali follow..  14  133.KCPVYSVCWSPEG-KRLITGCQTGEFTLWNGTAFNFET-----------ILQAHDSAIRALKWAS--NEQWLLSADQGGYVKYWQPNMNN--AHMFSAHKDEAIRGLAFAP-TDVKFATASD----DGTARVWDFARYTEERVLR--GHGAEVRCIDWHPTKGLIATGSRDQPVKIWDPKSGSCLTLQEHKSSVMAVEFNKNGNWLLTGGDHLVKMYDIRMMKEMRTYRAHKKEVISLAWHPIHEGLFVSGGGDG-SIVYWMVDGEKEIGLL-----------------EHAHDQAIWSMKWHP-LGHILATGSNDNNTKFWARNRPGDTVEDIFGLSNTNMIGHL...................................................................................................................................................................................................................................................................................................................................................................................................................................................... 440
46 -31.300[Z] KOG0313 Microtubule binding protein YTM1 (contains WD40 repeats)  ali follow..  13  101.DDWISSIKGAEEW---ILTGSYDKTSRIWSLEGK------------SIMTIVGHTDVVKDVAWVKKDSLSLLLSASMDQTILLWEWNVERNKALHCCRGHAGSVDSIAVDGSGTKFCSGS-----WDKMLKIWSTVPTDETPIVTLSGHMEAVSSVLWSDAE-EICSASWDHTIRVWDVGSGSLKSTLTGNKVFNCISYSPLCKRLASGSDRHIRLWDPRTKDGSLVSLSHTGWVTSVKWSPTHEQQLISGSLDN-IVKLWDTRSCKAP-----------------LYDLAAHEDKVLSVDWTD--TGLLLSGGADNKLYSYRYSP.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 416
47 -31.000[S] KOG0294 WD40 repeat-containing protein  ali follow..  11  3.............PEMEIIEATNEELLLGFKLIKSPTDGFSVKFELKQTFADSSYARSITSLA----VQWPWVASGGTDGRIFVYDMRTRKQ--SQIILSHAGRVNTLKFTPDLSLLLSGS-----DDGHMIATRVGSWTKEYDWQKAHAGQAVTHVSCHPSSKLALSLGGDQVLNTWNLVNGCVAHKTTLDFQTGCLSWSKQGDHFTLSGPLVLEIWGIEN-AHVMRRIEMPSKPICITWLDGN---ECLTGLDNGNIAWISLKDEDDTPP----------------TFILAHEVRVKAIAYLN---EFLATVSIAGQIKVWKIDM.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 290
48 -31.000[S] KOG0296 Angio-associated migratory cell protein (contains WD40 repeats)  ali follow..  13  61.KDSVFSVSINPVHSNLCASGGGDDLGYIWDITTGEQ-----------ICQLTGHKDSIVAIDWSF--DGTYIATGGMDSQVRLWKSSTGFE--FITAFETVDEIVWLSWHP-KGLFLAAGCN----DGSIWMWSLPSGKVVQVMY--GHTAPVNAGKFIPPGKRLATVDDSGTLIVWNPATGAPECRMSTAAGWTSFDCNAEGNVLFLGGSGKVKVVNINSSHILASLEAQTESVEAIALCTALP--ICACASVDGTVALYDSASLKFRKSLPHEQAVIDCKFLPNTPYLLTACADCVIRKWDVRDGKRVVTGSDDTELLVFDCEH.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 399
49 -30.900[S] KOG0293 WD40 repeat-containing protein  ali follow..  12  274.TDEVWFLQFSHNG-KYLASSSKDQTAIIWEISADGHISLKH--------TLVGHHKPVIAILWSP--DDRQVLTCGAEEVIRRWDVDSGD--CVHMYEKGGISPISCGWYPDGQGIIAGM-----TDRSICMWDLDGREKECWKG--QRTQKVSDIAMTDDGKWLVSVCKDSVISLFDREATVERLIE-EEDMITSFSLSNDNKYILVNLNQEIRLWNIEGDPKIVSRYKGHKRIRSCFGGYKQAFIAS--GSEDSQVYIWHRSTGKLIVELP------------------GHAGAVNCVSWSPTNLHMLASASDDGTIRIWGLDR.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 563
50 -30.900[R] KOG1310 WD40 repeat protein  ali follow..  8.DGNIFNLLHTRSQDPS-HEVDQRMQFHSSLVRRLSQEQ-----------ELEGHQGCVNALAWNS--NGSLLISGSDDLRINIWNYSS-RKLLHSIDTGHTANIFCTKFVPETSDLVVSGAG----DAEVRLFNTSRLSGIPSALYQCHTRRVKKLAVEPGNPNVWSASEDGTLRQHDFRESTSCPPPKQTLSLKSCDISATRPLLVGGSDAFARLYDRRMLPPLASS-RTNLHLTHVTFSPNGEEVLLSYSGEH--VYLMNVNNGTGIMQYTPGDVDNLFSFSNNLHDVESPPQVSTTPQNGFHRSSNAATVKKCTELVEIAKWSLEEGTDVFYAIEAANEVLDAHSNDIESALRHECLCTRAALLLKRKWKNDAHMAVRDCHNARRIDASSFKAHYYMSEALQQLGKCKEALDFATAAQHMNPSDADIVA---------KVESIKRDLQAAGAEKNEETGAGTTRVLSLSDILYRSEANSDSSHDMSRSEREDSDYDEELELDIQTSLSDDEGRDTDSNSMRGSLNLRIHRVGDDKPMENTVDNASS------------GTASSSQNDRTSYQPEGAIDMKRR------------YVGHCNVGTDIKQ-------------ASFLGQR----------GEYIASGSDDGRWFI--TGRLMKVLVGDESVLNCIQFDSVVATSGI------DNTIKIW-SVPSIVAGGSAGPATANVVEVMESNQQKLSRNREN----------PLSVELMQRFRMQEFAEGNFHPFEC.............. 751
51 -30.800[E] KOG0280 Uncharacterized conserved protein  ali follow..  13  1MSETADVCKYSQVFEDVLAVAHSTGHVSFYRHQFRAEL------MFLRGIKVADSSVLMLSLDFSD--SGKELAVSMSNGSVLIIDIDSGV--IKNKWKEHDYEAWTCHYSRQDNNLLYSGGD----DAALVCYDQRIPNSCIWRDIQVHHSGVVSISRAPFGPYIATGEYGDFMHTLDTRNIGKPLFSANGGGVWRLEHMETTEVLGILMHRGAQVLRISNDFSSIDASEHESMCYGGDWRHTDG-LLATCSFYDKRVCLWED......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 309
52 -30.600[R] KOG1334 WD40 repeat protein  ali follow..  10  277.AGSVSTIHFNQRG-TRLASSGDDLRVIVWDWVRQKPVLNF----------ESGHDINVIQAKFFPNCGDSTLAMCGHDGQVRVAELINASYENTKRVAKHRGPAHELALEPDSPYKFLTSGE----DAVVFTIDLRQDRPASVTRENDKKVGLYTISMNPANIYFAVGGHDQFVRIYDQRRIDKKENNGFPTNITCVVYSHDGTELASYNDEDIYLFNSSLSDGAQYVRNNDTIKCVNFYGPRSEFVVS--GSDCGHVFFWEKSSSQIIQFME-----------------GDRGDIVNCLEPHPYLP-VLATSGLDQHVRIWTPTAKTATELTGLKDVI............................................................................................................................................................................................................................................................................................................................................................................................................................................................. 606
53 -30.500[R] KOG2394 WD40 protein DMR-N9  ali follow..  12  134.NTSMTNTNFDGKGTYLVFNVSDAIFICDLNSQEKDPVK-----------SIHFSNSNPMCHAFDPAKDGHDLLIGLNSGDVYTVSLRQQLQDVSKSVNNRQDRCTSISWVPGGDGAFVVAHADGNTQFSVDKAKYSKSNP--VARWHICQGSINSIAFSNDGAHLATVGRDGYLRIFDFLTQKLVGGKSYYGALLCCSWSMDGKYILTGGDDLVQVWSMEDRKVVAWGEGHNSWVSGVAFDSNWSSPFGSVGQDTQ-LLLWDLEMDEIVVPLRRAPGGSDVPKLSPIIAHRVHTEPLSGLMFTQ---ESVVTACREGHIKIWTRPSESSTSFTKDNKASLSSK......................................................................................................................................................................................................................................................................................................................................................................................................................................................... 547
54 -30.500[J] KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis  ali follow..  11  447.TDLVRSVSVEPKG-EYLVSGSDDKTVKIWEIATG------------RCIRTIETDEVVRCVAWCPNPKLSIIAVATGNRLLLVNPKVGEQEKGVRVVITHFKPIRQVTWHG-RGDYLATVMPEG-ANRSALIHQLSKRRSQIPFS--KSKGLIQFVLFHPVKPCFFVAT-QHNIRIYDLVKQELVKLLTNSKWISGMSIHPKGDNLLVSTDKKMLWFDLDLSTKPYQTMRHRNAVRSVAFHLRYP--LFASGSDDQAVIVSHGMVYNDLLQNPLIVPLKKLQ-----THEKRDEFGVLDVNWHPVQP--VFSTGADSTIRLYT............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 784
55 -30.400[R] KOG0289 mRNA splicing factor  ali follow..  14  221.IPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILA-----------TLKGHTKKVTSVVFHP--SQDLVFSASPDATIRIWSVPNAS--CVQVVRAHESAVTGLSLHATGDYLLSSS-----DDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANPGHSGPITSIAFSENGYYLATAADSSVKLWDLRKLKN-TLQLDNNFEVKSLIFDQSGT-YLALGGTD---VQIYICKQWTEILHFT------------------EHSGLTTGVAFGH-HAKFIASTGMDRSLKFYSL............................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 504
56 -30.400[A] KOG0268 Sof1-like rRNA processing protein (contains WD40 repeats)  ali follow..  13  66.RDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIR-----------TIQAHEGFVRGICTRF--CGTSFFTVGDDKTVKQWKMDGPGGDEEEPLHTILGKTVYTGIDHHWKEAVFAT-----CGQQVDIWDEQRTNPICSMT--WGFDSISSVKFNPIETFLLGSCADRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIAANEDYNLYTFDMRALDTPVMVHDHVSAVLDVDYSPTGKEFVSA--SFDKSIRIFPVDKSRSREVY-----------------HTKRMQHVICVKWTS-DSKYIMCGSDEMNIRLWKANASEKLG..................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 361
57 -30.400[JT] KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1)  ali follow..  10.ERSITQIKYNREG-DLLFTVAKDPIVNVWYSVNGERLG-----------TYMGHTGAVWCVDADW--DTKHVLTGSADNSCRLWDCETGK---QLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNKEHSRQINDIQLSRDMTMFVTASDNTAKLFDSTTLEH-QKTFRTERPVNSAALSPNYDHVVL--GGGQEAMDVTTTSTRIGKFEARFFHLAFE----EEFGRVKGHFGPINSVAFHP-DGKSYSSGGEDGYVRIHYFDP.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 316
58 -30.300[S] KOG0295 WD40 repeat-containing protein  ali follow..  11  106.RLPITRVIFHPLW-TIMASCSEDATIKVWDYETGQLER-----------TLKGHTDAVNDIAIDA--AGKQLVSCSSDLSIKLWDFGQTYDC-LKSLKGHEHTVSSVTFLP-TGDFVLSASR----DHTIKQWDISTGYCVYTFR--GHNDWVRMIRISNDGTLFASASLDQTVTVWSFATKSAKVLRDHEHAVECVEWAPDTAYFSGSRDRSIKAWNINTGDVLFTLLAHENWVRGLAFHPKGKYLISV--ADDKTLRVWELSAQRCMKAIE------------------AHEHFVSTVAFHQ-TSPFVITGSVDMSCKVWECR........................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 404
59 -30.000[S] KOG0271 Notchless-like WD40 repeat-containing protein  ali follow..  13  147.KSWVLCIAWSPDA-TKIASACKNGEICIWNAKTGEQIGK----------TLKRHKQWITSLAWQPDPTCRLLASCGKDGNIFIWDTVQGT--VVRCLSGHTASVTCLRWGG--EGLIYSGSQ----DRTVKMWRADDGVMCRNMT--GHAHWINTLALNTDGERLVSGSDDFTLFMWNPKETKQSINRMHMQLVNQVVFSPDTRYIASASDKSVKLWCGRTGKYLASLRGHVGPVYQVAWSADSRLLVS--GSADSTLKVFELKTKSLYYDLP------------------GHGDEVFTVDWSP-EGTKVVSGGKDKVLKLWR............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 472
60 -30.000[R] KOG2919 Guanine nucleotide-binding protein  ali follow..  13  126.QHYTKGCYWSPDG-TCLLVPVHLDGMHVIEMPSDDTVQPARSLTKLQSEVHVPEGGTVYDCVWYPQPETCLWLATRQHEPIHMWDAFDGSLRCSYDAVDEVMAAISLAFSH-DGEQIYAGYKR-----CIKIFDTSRPG--RFCDDYPVKFAISCIAQTTAHPHTLTGNWHGYIQHFDLRCSHKQTLGGHKGGITQLRYGEFGNFSGARKCDKILQWDMRNYKQPLVELQHVDTNQRIQFDLASDSNWLASGDTRGFVNVWDLKKYGDPSVLP------------------LHSDCCNGVALNPAMPILATSSGQ..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 436
61 -29.900[R] KOG2321 WD40 repeat protein  ali follow..  52YPEASNRIKCTRDGKYAMATGVYKPHIKVFDFAEMSL-----------KFERHTDAENVQFEILSD--DWTKSVHLQTDRTVDFHSQGGIHYST-----RIPKYGRDLKYHYPNCDLYLAA-----AGDEVYRLNLEQGRFLNPLKIDSPTGGVNVIDINPMHQLLAFGTDAGSVEFWDPRDRSRVGISDNSRSVTALKYRNDGLNVAIGLDGATLLYDLRSSSPYMSKDGYSMPIKSLHWMDSALGTARVLSADSKIIKIWEKDTGKPFSSIEPTVELNDVCPIEGTGLILTANEGSPMHAFYIPDDYKFVTKKELLNLGLDHLVGTGVIRAYMHGFFI----------------DNNLYEKARLIANPFSYEEHRQKIVKERLEKQRASKIRSQNRPKVNAGLASRLSYQENKLRKKTGVTDGPSDERFKNVFT--DKEFEVDEDTLEYKQLHPSRSEARGLTAAEESEEEKEHTKGIKFSSDEESLSDMEEENETF------DALVDRRKTEQQVSNEKTPQETIRSTPSGMEMTFKVEKKKKSKPVNRDEDSTSGKKKQVTQGRRSASKNVFRNM.............................................................................................................................................................................................................. 634
62 -29.800[KL] KOG4283 Transcription-coupled repair protein CSA, contains WD40 domain  ali follow..  11  1MWEAIKDRETGRIRSNSFANRFKSRRILSLQLSNRKDF-------------VSPHRGSVNSLQVDL-TEGRYLLSGAADGSAAVFDVQRATDVDKQHENGHKYAISSAIWYPIDTGLFITGSF----DHYLKVWDTNTAQAVVDFKMPGKVYRTAMSSMAMSHTLIAAGTEDVQVRLCDIASGAFSTLSGHRDGVMSVEWSTSSEWVTGGCDGAIRFWDIRRAGCFRVL---DQSQTQLGFRPPILKRTAVGSKVCS................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 254
63 -29.700[S] KOG1409 Uncharacterized conserved protein, contains WD40 repeats and FYVE domains  ali follow..  31.VARINDVILLSKD-EGVWTASDDRSVRLYLKRDND---------QFWPSIHHFMPVAPTSLYYSE--ETYKLLVGLINGNVYEFSVADDSMTESRKWTCHAGPISGLGFALSSELIFSCSRDKGDHGGHVTVLRIVDNQPNLVSKLSAHTNAITSLTWDGNKKVLYSGSSDHLIIMWDIGGGRGEAYELHNGKVTTLCAAPAAKRLFSADHGKLMCWDMNCKRVETPEWKTSDCCQKCPFFWNLQAMWQRKVVGETKIRICNDCNARMKDNPQNFNLTPLA-------IPHEIHTGITAMHLQE-TLGLLVTSGQNRVIMIWDVRS.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 406
64 -29.700[S] KOG0283 WD40 repeat-containing protein  ali follow..  11  404.EGAVWTIKFSQDA-HYLASGGADRVIHVWEVQECELMSMNEGSSDKPVCSLKGHLDAILDLSWSK---SQLLLSSSMDKTVRLWDIETKTCLKLF---AHNDYVTCIQFSPVDENYFLSGS----LDAKIRIWSIQDR---HVVEWSDLHEMVTAACYTPDGQGALIGSHKGICRAYDTEDCKSNKKSQAKRKITSFQFSPVNPVLVTSADSRIRILDGSEVIHKFKGFRNTCSQLSASYSQDGKYIIC--ASEDSQVYLWKNDFHRTRSTLTTQSHEH......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 727
65 -29.600[R] KOG0288 WD40 repeat protein TipD  ali follow..  12  231.EGGCGSIVFEYNS-GTLFTGGQDRAVKMWDTNSGTLIK-----------SLYGSLGNILDMAVTH--DNKSVIAATSSNNLFVWDVSSGR--VRHTLTGHTDKVCAVDVSKFSSRHVVSAAY----DRTIKLWDLHKG---YCTNTVLFTSNCNAICLSIDGLTVFSGHMDGNLRLWDIQTGKLLEVAGHSSAVTSVSLSRNGNRILTSGDNVHNVFDTRTLEICGTLRASGSNWSRSCISPDDDYVAA--GSADGSVHVWSLSKGNIVSILK------------------EQTSPILCCSWSG-IGKPLASADKNGYVCTWT............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 515
66 -29.600[S] KOG0316 Conserved WD40 repeat-containing protein  ali follow..  12  18.EGAVLAARFNGDG-NYALTCGKDRTIRLWNPHRGILIK-----------TYKSHGREVRDVHVTS--DNAKFCSCGGDRQVYYWDVSTGR--VIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRGSVDGTVRTFDMRIGR----EMSDNLGQPVNCISISNDGNCVLAGCLDSTLRLLDRTTGELLQVYISKSFKTDCCLTNSDAHVIGGSDGLVFFWDLVD-AKVLSKFRAHDLVNSIDVDFYLRLLKFFVAGDKRELPPEGRLYVDFFGRWYNSCLEKMKK-----QQILTSIDFVIYVSNSPF............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 337
67 -29.300[R] KOG1188 WD40 repeat protein  ali follow..  10  27LGIDTSKTVQAGKE-NLVAVLCSNGSIRIYDKERLNVLR-----------EFSGYPGLLNGVRFAN--SCDSVYSACTDGTVKCWDARVAREKPVQLFKGYPNIFISFDINC-NDHIICAGTEKVDDDALLVFWDARMNSQNLSTTSETHSDDVTQVRFHPSNPNVVSGSSDGLVNVFDINIDNEVTTCNSISSVSCIGWSGKGYIYCMTHDEGFYWWDLNHLDTDNMKEDALDYLIGGLYHEKTDTLHVIGGTNKGRIHLMNCSMSGLTHVTSLQG---------------GHAATVRSFCWNV-QDDSLLTGGEDAQLLLWKPGA.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 352
68 -29.300[R] KOG0315 G-protein beta subunit-like protein (contains WD40 repeats)  ali follow..  37.TSQVNALDRTPDKTRLAACGYQCIRLYDLESNCTAP-----------VINFDGVQKNVTRLGFQE--DGNWMFTAGEDHHVRIWDMIAAP-PHCSRIFDCEAPVNAACLHPNQVEIAMGS-----QNGSVFLWDVKSERHERIVP--EVDASIQDVAISPDGRYLAAANNKGNCYIWSLTSQDQKMSTAHSRYILRCKFSPDSRLLLTTSDGTVCIWKTDDFSKWRELCIENYWVWDAAFSADSKWLFTA--SSDGIARLWKLQTKSSIRDYT------------------GHTKAITALSFKD-EIPVKSTNISDVQSSAKPPTQ-NLAFFETVGRVAMNPYM........................................................................................................................................................................................................................................................................................................................................................................................................................................................ 354
69 -29.200[ABO] KOG1446 Histone H3 (Lys4) methyltransferase complex and RNA cleavage factor II complex, subunit SWD2  ali follow..  12  23.TDKINAIDFAPNG-EHLISCSEDDQIVIYDCEKGTQSR-----------TVNSKKYGVDLIHFTHANNTAIHSSTKVDDTIRYLSLHDNK--YLRYFPGHTKKVISLCISPVEDTFLSGS-----LDKTLRLWDLRSPNCQGLM----HLSGRPIAAYDPEGLIFAAGVNSESIKLYDLRSFDKKLNQEKECDWTGLKFSRDGKTILSTNGSVIRLVDAFHGTPLQTFTGYPNNPIEASFSPDSQFIFS--GSTDGRVHIWNADTGNKVSVLN-----------------GDHPGPVQCVQFNP-KYMMLASACTNMAFWLPTSEE.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 315
70 -29.100[A] KOG0272 U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats)  ali follow..  13  261.TRPVSSAAFSEDS-SLLLTSSWSGLCKLWSVPDCELKQ-----------TLRGHASYVGGVALRPEENVVAMASGGHDGAVKLWGFNNEE-SIADITGHMPHRVSKVAFHP-SGRFLATACY----DSSWRLWDLEQK--TEVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIFLEGHLGAVFGVDFSPNGFHIATGSDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQECGSFLVTCSYDS-TTKIWSNKTWQPLKTLQ------------------GHDNKVISVDIAP-NSQYIATTSFDRTFKLWSPDS.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 553
71 -29.100[R] KOG1273 WD40 repeat protein  ali follow..  23.HGVIKCVAFNHRG-SLLAAGCADGGCVIWDFETRG---------IAKEIRDNDCSAAITSVSWSK--YGHRLLVSAADKSLTLWDVSTGEQRSKCPESNPPFSPAAACFNK-CGDLVYIGN----SKGEILIVDYKSVRVLALVSA-SGAAPVKNIVFSRNGQYLLTNSHDRTIRIYENLLPAKNKMKVTKMHWKAPCFSGDGEWVVGGSEHKIYIWD-RAGHLVKILEGPKEALIDLAWHPVHPIIVSV--SLAGLVYIWAKDYTENWSAPDFKELEENEEYVEREDEFDLIPETEKVKVLDVNEDEEVDIDTVEKD.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 403
72 -28.900[R] KOG0646 WD40 repeat protein  ali follow..  13  33.ASPAHGLTAVGEKSSQLSARNTSGSIFYWSWTKP------------QAEVKSYPVEPIKALAANN--EGTYLVGGGISGDIYLWEVATGK--LLKKWHGHYRSVTCLVFSG-DDSLLVSGSQ----DGSIRVWSLQQGNTLYEHNFNEHTMSVTDIVIDYGGCVIISSSEDRTCKVWSLSRGKLLKNIIFPSVINALALDPGGCVFYAGADSKIYIGAINATSEYGTQVEKGKAITCLAYCADGNLLIS--GSEDGVVCVWDPKSLRHVRT------------------LIHAKGSRKGPVNNIQIVRKTIVANSNKTQVSWKSRGALIP...................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 341
73 -28.800[D] KOG1036 Mitotic spindle checkpoint protein BUB3, WD repeat superfamily  ali follow..  58.GGAVLDCCFHDDFSGFSVGADYKVRRIVFNVGKEDILGTHDKAVRCVEYFDFSILFFYTLCLFCD--VTGQVITGSWDKTVKCWDPRGASGPERTQVGTYLQPERVYSMSLVGHRLVVAT-----AGRHVNIYDLRNMSQPEQRRESSLKYQTRCVRCYPNGTGYALSSVEGRVAMEFFDLSEAAQAKKIVYPVNSIAFHPIYGTFATGGDGFVNIWDGNNKKRLYQYSKYPTSISALSFSRDGQLLAVASSYTPEAIFVRSVNEIEVKPKPKVYPNPAA........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 354
74 -28.800[R] KOG2096 WD40 repeat protein  ali follow..  11  86.GDAVTGLCFSSDG-KSLATACADGVIRVFKLDDASSKSFNRWEFTLQAHFHDLTVGHPTAVAFADDDGSVVIASCSEGTDIVLWHGKTGR--NLGHVDTNQLKNHMAAVSP-NGRFLAAAAF----TADVKVWEIVYQKDSRVMQLKGHKSAVTWLCFSPNSEQIITASKDGSIRVWNINVRYHLDSGGNPLHYDRLSLCPEGKILAASHGSTLQWLCAETGNVLDTAEKHEGDITCISWAPKAHAMVLGTSGDDKKVKLWEAPKSQ..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 452
75 -28.700[BL] KOG1009 Chromatin assembly complex 1 subunit B/CAC2 (contains WD40 repeats)  ali follow..  13  13.KEPVYSLDFQHGTAGRLASAGVDTNVRIWKVEKGPDGKAIVEFLS----NLARHTKAVNVVRFSP--TGEILASGGDDAVILLWKVNDNKEPEVKTLRGHLEDVYDICWAT-DGNLMASAS----VDNTAIIWDVSKGQKISIFN--EHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKKRVAFNDSMKSFFRRLSFTPDGSLLLTAGCVESGENVMNTTRPIAHLPCPGKATLAVRCCPVYRLVFAVASEDS--VLLYDTQQSF-----------------PFGYVSNIHYHTLSDISWSS-DGAFLAISSTDGYCSFVTFEK.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 377

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.