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Query: [R] KOG3518 Putative guanine nucleotide exchange factor, from COG1018

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MCAAQAHQHCSTSVAGDRLLGSSTELAPSLLGIYDTLTNSFAAGGVAAAPTATSHESKASSSGDSTPKRSNSNCSSSSSTGSSTGSCSSVPTSDDQSASYTLASSSTHLGHQEPPAPLVVAGLRDEPDGAQLSRLVQRRSQESQIHGSSSSIASSGSSRRGSNIRILSPNVHRIITHSDIQPVEAVSAEALKQHQQQSQRSPTQGRYIKTGHSGTPPAAGSAPKLKLSHIPLSKITGKLSTQSGSELVSTFDSSNEYLNSVAFAAFEKSKPQDEDRTPTNKSVPGTPFHFDGHPFQGRKLTLPRYDSQQSIKLIEMEQLAATSAQLLHAKPATPGTPATPTPSATKAKEFVCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEGECFPLGLast
1 -131.000[R] KOG3518 Putative guanine nucleotide exchange factor  ali follow..  100  1MCAAQAHQHCSTSVAGDRLLGSSTELAPSLLGIYDTLTNSFAAGGVAAAPTATSHESKASSSGDSTPKRSNSNCSSSSSTGSSTGSCSSVPTSDDQSASYTLASSSTHLGHQEPPAPLVVAGLRDEPDGAQLSRLVQRRSQESQIHGSSSSIASSGSSRRGSNIRILSPNVHRIITHSDIQPVEAVSAEALKQHQQQSQRSPTQGRYIKTGHSGTPPAAGSAPKLKLSHIPLSKITGKLSTQSGSELVSTFDSSNEYLNSVAFAAFEKSKPQDEDRTPTNKSVPGTPFHFDGHPFQGRKLTLPRYDSQQSIKLIEMEQLAATSAQLLHAKPATPGTPATPTPSATKAKEFVCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEGECFPLG 867
2 -75.900[T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac GTPases  ali follow..  18  32......................................................................................................................................................................................................................................................................................................................................................SHSSSENGGKSESVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQG--SADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRI-EEKGVPEGKDKIVFGNIHQIYDWHKDFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY------DAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSECSDIEKAVELMCLVPKRCNDMMNLGRLQG------------FEGTLTAQGKLLQQDTFYVSRTKERRVFLFEQIVIFSELLRKPGYMFKRSIKMNYLVLEENVDNDPCKFALMN-RETSERVVLQAANADIQQAWVQDINQVLETQRDF-LNALQSPIEYQRKERSTAVMR 555
3 -66.600[F] KOG2070 Guanine nucleotide exchange factor  ali follow..  19  221..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPQRVGGCFLNLMPQMKLYLTYCANHPSAVNVLTEHSE--ELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMDRQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQEKNERYLLLFPNVLLMLSASPRSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSV............. 571
4 -51.300[T] KOG2996 Rho guanine nucleotide exchange factor VAV3  ali follow..  17  131..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKR---LTAAEFDSVFINIPELVKLHRNLMQEIHDSIVNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKEVKLKLEECSKRANGKFTLRDLLVVPMQRVLKYHLLLQELVKHTEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENL-NQPVLLFGRPQGDGEIRITTKQERHIFLFDLAVIVCKR-KGDNYEMKEIIDLQQYKIANNPTTDSYGFYL-IHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTS... 526
5 -48.800[T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange factor/faciogenital dysplasia protein 3  ali follow..  17  95................................................................................................................................................................................................................................................................................................................................................................................................................................................AAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANFPAEMVNKIFSNISSINAFHSKFLPELEKRMQE-PRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTEIPQFKSVVEEIQKQ--GSLTLQHHMLEPVQRIPRYEMLLKDYLRKLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEED--VNPSNELIKEGQILKTSAQERYLFLFNNMLLYCVPKFGSKFTVRTRVGIDGMKIVETQNEEPHTFQV---SGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNA............... 533
6 -42.100[T] COG5422 RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases  ali follow..  11  7.......................................................................................................QNGNINSESHESFGKAAKGFRIFSSFSSSQKLFQRRSSGSITHSPTALSSTTSLNENDGNHFRPASSLSFSPSSLSRKDSGPGDGLEVNKKNNFYRRSSSTDDFGISHARSRKEIQSLGRPHTRQSFSVSDVSNGSSYPNIRKNSVHVNAPMPSFPEGSTAVLLKHHSGSKSASAISNIAPSHSNSTSSRRPYIHPAFLSQVAVEFRKRLNIGDRVKDGLLYKDAFLGSEAVDVLMHIVRTTDRNLALLLGRALDSQKMFHDVTYSHRLRDSLKEVYQYRRIISPPPGLSSMDSNGSSIENNFLYTKRRANTSDSFDSVLSDSSTTPTISSSVQVNSLAFITSSLSAITKEPEAPETEYNPHGVFTLLTECYSSTCSRNRLCYSISCPRRLEQQARLHLKVQPVLSGGSTSITDKQEEDHRLWSENVPKQVVDQIDVREWKRQEIIFEVIYTERDFVRDLEYIRDFWIKPLSTSNVIPENNRQCVFHNIMQIHAVNSRLSNALNRTQTL-NTIGDLFLDYVPKFEPFIKYGANQAIAKFEFREKSTNRNFANYVHEVERL--RKLELNGYLTKPTTRLARYPLLLSGVLKYTDTENIPRVIEMIREFLTKLNYETGKTENRLSLLQLNEQLS--AKLTLFDPSRLIFKGVVKLKTENDIHMFLLDNFLLLCKIKIQMKRLHLRPLPLELLSISYIEDSPSRGLQLVFIGARGFSISLYLNTLIARDQWKQHIEK.............................. 800
7 -37.000[T] KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE)  ali follow..  18  295...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TGKLHRKPLESSSVSSPIGKSLRSQNSRSLSSMRDCSVEGPTSLNMTPDYIYSNDDVENSCKSPRQPSKRLRVCMEMVETEKNYLSLLKLVVKFKECEISHNEFMSRSDVAMMFGKLDPILELHERIFARLTVMSNE-LDFAQVWIDAKEEMKAYPQYINSYDTIKRLFDKQDENSKFHTFCKAKESN--HRLKLTDLMVKPVQRLPSVILLLKEMAKKSDSKLAEEAAKAIDEVLKTANKTREKNDNFISHLSKFTDIENVPPILVAANRMFIRELVVSLQQFAKMKLFLFHDVLIITKIRSEKNTMQRRHASFASLHSRQQLNTMRSAFRIRAPDEIAKCLELQQQNGSTKPNVFVWCLIHRDEQ......................... 706
8 -25.700[T] KOG4269 Rac GTPase-activating protein BCR/ABR  ali follow..  16  33.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGRGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLL-PMKPLKSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNQFQKISEELKKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTDYPLLQDALRISQNFLSSINEDIDPRRTA-------------VTTPKGETRQLVKDGEVSESSRKLRHVFLFTDVLLCAKLKKTSQYDCKWYIPLADLVFPSPEESEASP------SALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKS.... 436
9 -10.000[U] KOG2215 Exocyst complex subunit  ali follow..  10  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MLSNEDGLFQTDAFSPSDYIRDRLKGVKIGDETRKL-----SEMGALNHASQETLKN-------------------NVFRNY--------------------QQFID---------------ASKEISHLEREIYQLTHSLIEQKQENLIMMTGDDKSSIHTVSSHSTTTSTTNPIQILMQKMEGIGG--VILYGEMEQFDVETKKPVQKCMLILLSHRLIIGNINAAGKYVMESTLSLNSVAPVNVKDRES-VLKL----IFPESRCYLCESARIRTLWFDELEQAKREILHKGSLVRQATIRGKRQTVKERKA. 273
10 -8.360[J] COG5099 RNA-binding protein of the Puf family, translational repressor  ali follow..  8  43..QQQPQKLGSYRSRAGKFSNTLSNLLPSISAKLHHSKKNSHGKNGAEFSSSNNSSQSTVASKTPRASPSRSKMMESSIDGVTMDRPGSLTPPQDMEKLVHFPDSSNNFLIPAPRGSSDSFNLPHQISRTRNNTMSSQITSISSIAPKPRTSSGIWSSNASANDPMQQHLLQQLQPTTSNNTTNSNTLNDYSTKTAYFDNMVSTSGSQMADNKMNTNNLAIPNSVWSNTRQRSQSNASSIYTDAPLYEQPARASISSHYTIPTQESIADEIDPQSINWVTMDPTVPSINQISNLLPTNTISISNVFPLQHQQPQLNNAINLTSTSLATLCSKYGEVISARTLRNLNMALVEFSSVESAVKALDSLQGKEVSMIGAPSKISFAKILPMHQQPPQFLLNSQGLPLGLENNNLQPQPLLQEQLFNGAVTFQQQGNVSIPVFNQQSQQSQHQNHSSGSAGFSNVLHGYNNNNSMHGNNNNSANEKEQCPFPLPPPNVNEKEDLLREIIELFEANSDEYQINSLIKKSLNHKGTSDTQNFGPLPEPLSGRERELRKSIDSNAFSDLEIEQLAIAMLDELPE---LSSDY----LGNVQKLFEHIKDIM--LRKTSKYLTSMGTWACQK-------ITMAHTPRQIMQVTQGVK--DYCTPLINDIQCVLKFGFPWNQFIFESI-VIVRY--AVRACLEAHDIVTPEQSIVLSAMIVTYAEYLST-----------------------NSNGALLVTWFLDTSVLPNRHSILAPRLT-LCGHRLASLTILKRKIILDSLNVNAHDSSPPKELTKLLCETNYGPTFVHLLEDDLRAHIIKQVRKVLSTQIQPSRRLLEEVGLASPSSTHN.... 919
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Dunbrack RL Jr, Dunker K, Godzik A. Protein structure prediction in biology and medicine. Pac Symp Biocomput. 2000;(12):93-4.