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Query: [C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase, from COG1018

Results of PSI-BLAST search in nr85s
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# E-value Template Links and tools%idFirst MIDMKLAILGAGCYRTHAASGITNFSRACEVAEMVGKPEIAMTHSTITMGAELKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKVNEVAKELPKPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDMQPGIIDKFIDDIKPGAIVTHACTIPTTKFYKIFEEKHGDLVTKPETLNVTSYHPGAVPEMKGQVYIAEGYASEEAINTLFELGQKARGNAYRLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLGAPAGFAQMMAKESLEQITALMEKVGIDKMEEHLDPGALLGTADSMNFGASADILPTVFEILEKRKKLast
1 6.000e-67UniRef50_Q58029 Probable arogenate/prephenate dehydrogenase n=13 Tax=Methanococcales TaxID=2182 RepID=Y612_METJA  ali  14  13.......................................................................................GTDGLGKWFARLKNKGFNVIVTGRDIEKGK---NVEKELGVEFTNNNIEAAKKGDIVIVAVPIN-VTERVIKEVAPHVREGCLLMDITSIKEIPSKAMEEH-------VKEGVTVIPTHPMFGPSTPSQVVILTPHKNTEWFNKVYNFLKKEGAKVIVIPPEKHDRIMGIVQGLTHFAFISLGATLKELNVDIKESRKFASPIYELMISIIGRIIGQNPLYADIQMFNPETFINQCKEISEIVKNKDREGFVKIMKEAAK 275
2 2.000e-64UniRef50_A0A1D2WDE9 5,10-methenyltetrahydromethanopterin hydrogenase n=3 Tax=Methanobacteriaceae TaxID=2159 RepID=A0A1D2WDE9_9EURY  ali  84  1...MKIAILGAGCYRTHAASGITNFTRACEVAEMVGKPEIAMTHSTMTMGAELMELAGVKDIVIADPVFDNDFRVIDDFDYENVIEAHKENPESVMPQIREKVNEVAKDLPKPPKGAIHFVNPEDLGFEVTTDDREAVADADFIMTWFPKGDMQPAIVDNFLDDVKKGATITHACTIPTTKFSKIFAEKHGDLVTSPETLNVTSYHPGAVPEMKGQVYIAEGYATDDAINTLFELGQKARGNAYKMPAELLGPVCDMCSALTAITYAGLLGYRDSVMNVLGAPAGFAQMMAKESLTQITDLMDKVGIDKMEESLDPGALLGTADSMNFGSTAELLPTILESLNK... 341
3 1.000e-63UniRef50_M1YWG4 Prephenate dehydrogenase n=1 Tax=Nitrospina gracilis (strain 3/211) TaxID=1266370 RepID=M1YWG4_NITG3  ali  14  1...................................................................................MTIIGVGLLGASLAKVC-KERQITGRIAGFGRNADNLKRAEEQGVHGTTDLKDAVAGADLVVLCSPVASIVER-FREMAPHLDAGCIVTDVGSVKAPLVQDIEPLL-------PEGVHYVPAHPIAGAEKSGCILTPTDNTDKATLERIQQFWEAVGMRVQILTAEEHDFIYGAVSHLPHVVAFALINAIGQLKTDQEDILSLS----AGGLRDITRIASSDPMWRDICLANKTHVLDMIDRF-----SKSLEDIRKQIEQDD. 262
4 4.000e-63UniRef50_A0A1F8YB18 Prephenate dehydrogenase n=7 Tax=unclassified Deltaproteobacteria (miscellaneous) TaxID=122706 RepID=A0A1F8YB18_9DELT  ali  15  4..........................................................................VKREIHFKKVAIIGVGLIGGSIA-IVLREKGITKSIIGIGRGVKNLEAAKKLGVEFTQDVKEGVKDADLVVAAIPVASIAR-VIREALPFFKNGAIITDVGSVKKSIVDEIESFL-------PPEIHFVGGHPIAGTENAGVEITPTKKTGRTALEKVKRIWEIAGSEVILMDAERHDRILAAVSHLPHVVAYALVNTVSGVRDFDEDIVKYS----AGGFKDFTRIASSPPMWRDICLLNRDAILDVIRRFRQLIAGNNSEGIMREFEKAK. 285
5 5.000e-63UniRef50_A0A2E6XNQ0 Prephenate dehydrogenase n=7 Tax=Bacteria TaxID=2 RepID=A0A2E6XNQ0_9BACT  ali  15  5.......................................................................................GVGLLGASLAKACRKYN-LVEEILGYGXNLENLKKAKSLGVIYAGDLREAVKDCDLIVLCTPVSSIVP-LIESLLPHLKVGAVITDVGSVKGPLVHEADK-------LXPEGIFFVGSHPIAGGEKSGCILTPTPKTDTQALEKVGALWESVGMDTCTLDADEHDFVFGAVSHLPHIVAYTLMNTLGALRTNQDHVTGYSG----AGLKDXTRIASGDPMWRDICLLNQKHFQNKLNELSNLIEKNDGEALEEAFSAANK 275
6 5.000e-63UniRef50_Q6LX39 Prephenate dehydrogenase n=7 Tax=Methanococcus maripaludis TaxID=39152 RepID=Q6LX39_METMP  ali  12  14............................................................................................KWFASFLKNRGYDVLVSGRDVIKGK---EVEKELGVTYTNNNIDAAEKGDIVIISVPIN-VTESVIKEVAPHVKKGSLLMDITSIKERPAKLMAE-------FSKTGVFVLPTHPMFGPETPSQVVILTPTEKEKTFEKIKEFLEIEGAKVIVVSPKEHDKIMGVVQGLTHFVYISLGSTLKDLGIDIKESRNFASPIYELMINIIARIIGQNPLYADIQMHNPETFIKNCENISEIVQNKDRDSFVENMKNSAR 270
7 6.000e-63UniRef50_A0A063Y3H9 Cyclohexadienyl dehydrogenase n=61 Tax=root TaxID=1 RepID=A0A063Y3H9_9GAMM  ali  15  1............................................................................MSDRLKCVLVVGLGLIGGSFARAV-KMRGLADRVVGYDLNPQECQLGLQLGVEQAEDLLQAAAEADLVMLAVPVKA-TEALLETLAPVLKPGTLLTDVGSTKMNIIEAGQRVFGNLPAC------FVPGHPIAGAEKSGVKVILTPLTDASAVSRLASLWQALGADVLQMTPQRHDEVLAATSHLPHILAFSLVDTLAHEEQN-KDIFRYA----AGGFRDFTRIAASDPMWHDICQANRDALLSQIDQFTTG-----LARLREAIDQGD. 268
8 1.000e-62UniRef50_A0A1G1FBA7 Uncharacterized protein n=1 Tax=Nitrospirae bacterium GWC2_57_13 TaxID=1801697 RepID=A0A1G1FBA7_9BACT  ali  15  11.......................................................................................GVGLIGGSLAR-VMKTGKLAGTITGAGRSKATLEEALGLGVRIAENLGEAVEGADLVVLATPVATF-EAIAREIGPRMKEGAIVTDVGSVKGRFVKALEKLL-------PKNIRYVPGHPIAGKEKSGVILTPTERTDPEALAAVETLCRAAGAQVRRMDADLHDRVFAAVSHLPHVAAYAMVCTVAELNTGSEEYIDFSG----GGFRDFTRIASSPEMWRDICLLNGNNIIEMIDRMKRAIRTKDSNKLEGLFRSASD 280
9 1.000e-62UniRef50_A0A2H6JWJ9 T-protein n=1 Tax=archaeon BMS3Bbin15 TaxID=2005738 RepID=A0A2H6JWJ9_9ARCH  ali  13  5...................................................................................AVIGGTGEFGSMFARIFREEGN---EVLITGRNKETGKKVRSLGVGYTRSNTEAAEWADVVIISVSI-ENTPDVIKEVAPHVREGSLLMDFTSVKVEPCRAMLK-------YSGKKVEIIGTHPMFSPRVTGLEFIVTPVRTEKWMDWLKEWLEDKKARVIITTPEEHDRIMSVVQGLTHFTYLSVASTLAEMKIDVKETRKFASPIYELMIDLIARIVGQNPLYAGIQMLNPEAFIDRAIEFNNIIDRKDKDAFVKEM..... 263
10 3.000e-61UniRef50_A0A0S8DJR8 Uncharacterized protein n=3 Tax=Bacteria TaxID=2 RepID=A0A0S8DJR8_9BACT  ali  15  13.......................................................................................GVGLLGSSFA-LSLRKHGFEGTITGIGRNRDNLIRAKKLSINWTSSHESGVEDADLILLASPVDKFK-GIIEKIQPNIKRGAIVTDVGSVKADIVSSLE-------PLMPEEVFFVGSHPIAGKETSGIIITPGPNTDREAFKKVRRLWEALGSETVVMSPEEHDFIFAAVSHLPHVVAYSLVNSIMEMDSNI--------LYFGGGLKDMTRIASSPDLWQGICSFNRENLLKSLRYFSDFIEASDWEGLQKEFRKGQK 279
11 2.000e-60UniRef50_A0A2E2YIM0 Cyclohexadienyl dehydrogenase n=12 Tax=Proteobacteria TaxID=1224 RepID=A0A2E2YIM0_9PROT  ali  15  9.............................................................................DFLFQSVTLIGIGLIGSSIARAIKKTEYIVENLVLTDVDKLVRAKAKKLGDSVEDNLCAAVVGADCVILCTPIGNYA-EIIESISGHLKPGCIVSDVGSVKRAPITDM-------SPYIPENVHFVPGHPIAGTEKSGPELTPPVGTNRKAVKKMRCLFEAIGAMVEEMDPDYHDKVLALTSHLPHLIAYTIVGTADDLEDQTADVIRFS----ASGFRDFTRLAGSNPMWRDIFLNNREAVLEMLQRFSEAIRWGEADTLEELFTRTRK 290
12 4.000e-60UniRef50_A0A2I0QDZ5 Prephenate dehydrogenase n=5 Tax=unclassified Candidatus Altiarchaeales TaxID=1849260 RepID=A0A2I0QDZ5_9EURY  ali  16  8...................................................................................VIIGGYGGMGELFARLLDEGYKVIVTGPTESKGK---KAEKELGVRYMKDNCEAVKSGDIVIVTVPI-DYTIDTIKEVAPYVNPGALLTDFTSVKEGPCNAMVE-------FSKNGVEVIGMHPMFGPGLEGQVVVLAPMRPSKWVPFLLEFLNKHKAKIIESTPEEHDTVISVVQGLTHFTYISVGKTLKDLNFDIKKSRQFASPIYALMLDMVGRIIGQDPLYASIQMTNPKAFFKSAKELSKIVKNQDHDKFVEYMSDAAK 276
13 5.000e-60UniRef50_A0A245Z7P9 Uncharacterized protein n=1 Tax=Rhizobium yanglingense TaxID=61013 RepID=A0A245Z7P9_9RHIZ  ali  16  303................................................................................FDRIALIGIGLIGSSIAHDIKRL-GLANEVVVATRSAETLKRAEELGSRYTTSSAEAAENADLVIVSVPVGA-SESVAKEIAGSVKPGAIVTDVGSTKASVIAQMQPHM-------PPHVHFIPGHPLAGTEKSGPDCIFTPGTDEGALKKLRKFWESLGSKVDEMDADHHDKVLAIVSHLPHIIAYNIVGTADDLETVTEEVIKYS----ASGFRDFTRLAASDPMWRDVCLHNKDAILEMLARFSEAIRWGEGDKLFELFSRTR. 579
14 5.000e-60UniRef50_A0A2M7SIX7 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=2 Tax=unclassified Deltaproteobacteria (miscellaneous) TaxID=12  ali  13  6...............................................................................LFDKVAIIGLGLIGGSLAKAA-KGENLFKKVVGIGRNEKNLKKGIDLGATYTTHLAEGVSDVDLVVVATPPG-VIIEIIKKVVRYIPDGCIITDVGSIKEEIVKGVERFIPDN-----DNIYFVGGHPIAGTENSGIECVLTPTTNRNALERIKTMWEKVGCKVISMDMAKHDNIFAIVSHLPHVVAFSLINAIINIKDNKEDILSYS----AGGLKDFTRIAASHPMWKDIFLMNKENVLNSLEEIKRAIAEEDSEKLVSEFQKSRE 285
15 8.000e-60UniRef50_H6QDT3 3-hydroxyacyl-CoA dehydrogenase n=7 Tax=Thermoprotei TaxID=183924 RepID=H6QDT3_PYROT  ali  12  9.......................................................GAGTMGHGIAEVAALAGYEVYIYDISAEILNKAIEKIKWSLEKLYEK-------------RRISSVEEVLSRIRATLNFEEAARNSDIGIEAVPENQLKRDIFARLDSLMHEDAILTNTSSLPISEIAEATRRP-------NKVVGIHFFNPPVL--MQLVEIIKGNKTDDDTVRRSFEFVKSLGKTPIIVNRDVPGFIVNRILGAIQNVACHLVEIDSAVKYKAGLPMGLFELRDFTGIDVAKALAERDPLFRQEC----PLIEEYYKKGWLGVKSG--KGFYEY...... 280
16 1.000e-59UniRef50_A0A1G1DXB4 Cytidylate kinase n=2 Tax=unclassified Nitrospinae TaxID=1449243 RepID=A0A1G1DXB4_9BACT  ali  13  12.......................................................................................GVGLIGGSFARVC-KNKKLADRIIGFGRDEKNLKRAVELNVSYSLNLRDAVSNSDFIILATPVFSIIK-IAREMMPYLKKGAIVTDAGSVKGEIVREIDEILS-------KEIFFVGAHPIAGTEKSGVEITPTDKTNSVALEKAKEIWSETGSEVILMDADKHDRYLAAVSHLPHAVAYALVNAVGGLDEKEKGVLSFS----AGGFRDFTRIAASPAMWRDIFSMNKKNVVEMLEDIKEAISNNDGKKMEKEFEKAKE 281
17 1.000e-59UniRef50_A0A1Z5HN78 Prephenate dehydrogenase (Fragment) n=1 Tax=Calderihabitans maritimus TaxID=1246530 RepID=A0A1Z5HN78_9THEO  ali  13  26.......................................................................................................GNVVEQVVGIDRDRNSLELATQSIHHGTQDLEQGVRGADLVILAVPLGQIVP-VAREIKPFLAPGSIVTDVGSTKVDIVKNLEELFYPQ-------IHYVGGHPMAGSERAGIELTPTERTDRQALEIVTALIEKTGARVKTVSPEEHDLIVAAVSHLPHVIAAALVNTVGGLADEYPDIL----TLAAGGFRDTTRIAGSNPLWRDICLANAEKIIKWLDQFEAVMAAGDKDTLTGIFRQAQE 280
18 2.000e-59UniRef50_A0A0E1WZ19 Cyclohexadienyl dehydrogenase n=2 Tax=Brucella TaxID=234 RepID=A0A0E1WZ19_9RHIZ  ali  16  6................................................................................FDKITLIGIGLIGSSLARVIRRE-GLATHIAIATRSAETLKRAEELGDSYTTNSAEAVKDADLVIVSVPVGS-SGTVARQIAGNLKPGAIVTDVGSTKASVIAQMQ-------PELPENVHFIPGHPLAGTEYSGCILTPLPDTDEKALEKLTAFWTACGSRLDHMDPQHHDLVLAIVSHLPHIIAYNIVGTASDLELVTKKVIKYS----ASGFRDFTRLAASDPMWRDVCLHNKDAILEMLGRFSEDIRWGDGEALFDLFTRTR. 282
19 2.000e-59UniRef50_A0A1V4VZJ7 Prephenate dehydrogenase n=1 Tax=Pelotomaculum sp. PtaB.Bin104 TaxID=1811693 RepID=A0A1V4VZJ7_9FIRM  ali  13  5................................................................................FNRVAIIGVGLIGGSLG-MALRARGLAGEVVGSGSRAENLQLGVELGARFTGSIEAGVAGADLVIIATPVSA-TITVLEEILPYLSPGTIVTDVGSTKGGIVRAAEKL-------VPKGIAFVGGHPMAGTERTGVKITPHEHTPAQAVAVLKKMAGGVGAKVIEMEPERHDLAVAAVSHLPHFIAVSLVNTVAQMTASDEIL-----PLAASGFRDTTRIAASPPMWRDIFHANREQLLDMIRRF..................... 252
20 2.000e-59UniRef50_K4ZG23 Prephenate dehydrogenase TyrA n=58 Tax=Bacillales TaxID=1385 RepID=K4ZG23_PAEAL  ali  16  1...............................................................................MRTKITIIGVGLIGGSLALCFKNRPGI--HVVGYSPSQSSAEKYIERGVEATTSLRDAVEDADYIFVCVPVG-MLESMLNDLQNLLKPGCIVTDVGSTKSSVARCAR-------GLQWEDVHFIGGHPMAGSERSGVEYVLTPDANEEAYSRLVSLLRYTKAHIIRMNPEEHDEVVGAISHLPHVVAVALVNQVRSYNEN----NELYELLAAGGFRDITRIASSDPIWRDILINNRDVVLRLLEQFIDILQRQDGEGIIQQFAEA.. 276
21 3.000e-59UniRef50_X1WJP5 Uncharacterized protein n=12 Tax=Metazoa TaxID=33208 RepID=X1WJP5_ACYPI  ali  13  10........................................NFSISTLTRAAITVVGGGLMGSGIAQISAQSGHNVTIVELNQEVLDKTHKNIQQSLQRVAKKVYK-----EKPQEGENFVSESLS-RISTSTNLADVVQNSDLVLEAIVENSIKHKLFKSIDDIAPEKTIFANTSSLSIGEIAAVCKRKD-------KFAGLHFFNP--VPVMKLLEVVRTPETSDETYEKLMAWAKAIGKTAITC-KDTPGFVVNRLLVPLMAEAIRMLERGDASPRDIDHPMGPIELADYVGHDTTNSIINGWHEFPENPLFNPPSLQKLVDEKKLGIKTGE............. 302
22 3.000e-59UniRef50_A0A1W9LIJ3 Uncharacterized protein n=1 Tax=Elusimicrobia bacterium A5 TaxID=1933928 RepID=A0A1W9LIJ3_9BACT  ali  14  7.......................................................................................GVGLIGGSIGLAIKKSGLKVKKVIGIGRNLERLKLAKKIGAEITTDINEGVKNADIVFVCLPVGLIAQTT-KSIFPYCKKDAIITDVGSVKQPIVNDIEKFL--NTYHLPLTAVFIGGHPIAGSEKTSVKYAPTEKTDRKSLDIVKKLWEKMKAKVKIMSPTRHDRILAMTSHLPHAVAFALVNSADNFEF------------AGTGFKDTTRIASSDPMWADIIFNNRCAIKRIKFELGKIEKEKTVKKLVDIFKKAK. 270
23 4.000e-59UniRef50_A0A1F7S180 Uncharacterized protein n=2 Tax=Candidatus Schekmanbacteria TaxID=1817811 RepID=A0A1F7S180_9BACT  ali  12  1............................................................................MGFLFNKIAIVGVGMIGGSLAMAIKK-KGIAREILGIDIDRKNLDEAKKSGIDYALNFKSELQKVRLIIVATPVRSIPRAI-EKLSPWLDEGTIITDTGSVKGSVVKDIEDILQ-------KGVFFIGGHPIAGSELSGVKIILTPTNSSPALRKVKEFWTRLGSKVILMKPKEHDRVFAAVSHLPHILAFSLVNTLSELHFNNQNPFKFAG----EGFKDFTRIAQSNPMWHDIVLENKDQILDSMDHFKSLIEKSEGKKIRKEFSKAQK 283
24 4.000e-59UniRef50_A0A2H5W929 3-hydroxybutyryl-CoA dehydrogenase n=18 Tax=root TaxID=1 RepID=A0A2H5W929_9BACT  ali  14  14.........................................................GLMGSGIAHVTAHAGYSVVVREVSPELLEKGIQNVRNSIQR------------WSVRKGQMTEEEGQSLRIQFTTELQP-LADCDLVIEAITEMDMKKQLFRELDKICKPEAIFANTSSLCITEMAVVTKRPA-------RFLGLHFFNP--VPVMKLVEIIRTDLTAPETVETVLGFVQTLGKTPVRA-PDRPGFIVNRLLVPYLLDAVRCLEIDQAMVLGCGHPMGPFTLLDFVGLDTTYYIAQAMYDEFKDPRYAPPPLLKRMVLAGFHGRK............... 277
25 5.000e-59UniRef50_A0A2H6FKG6 Cyclohexadienyl dehydrogenase n=1 Tax=bacterium BMS3Abin08 TaxID=2005716 RepID=A0A2H6FKG6_9BACT  ali  14  26.....................................................................................................KRRGLAREVVGSGRTEENLRRAREILDGYSINHKEAVKGADLVVLATPVGRFV-EITKDISGSLKPGSLLTDVGSVKGSIVRRIEEV-------VPDGVRFVGCHPIAGSERSGIDVVLTPTTAADALSRVGKFWEALGAVVTRLSPEEHDLVFALLSHLPHLVSYALVNTLSDTDPDYINLSG-------SGFRDTTRIASSPELWTEISLYNRDNLLRLIESFRKALDKGDAEHLRRLFENARD 279
26 9.000e-59UniRef50_A0A1S7LNS3 Tein tyrC: Cyclohexadienyl dehydrogenase Prephenate dehydrogenase n=3 Tax=Bacteria TaxID=2 RepID=A0A1S7LNS3_9BACT  ali  12  1............................................................................MSFLIKQLTIVGVGLMGASLA-LALKRKDLVGEVVGVDRRRNSLDYALENGVRATTSIAEGAKGASVVLIATPVAAIVPTV-KDCLPGLEPGCVVTDVGSVKGNIVAQCEA-------MMPEGCSFVGGHPIAGREHSGVELTPSDTTDKQAVELISEMWEAVGAGVEKMEPAWHDQVLAATSHLPHLMAYNVVNTLSDLE---DHLRSEVFRYAASGFRDFTRIASSDPMWRDICLENRDAIL-----TILNRFRDDLDKLTTRVESGD. 269
27 9.000e-59UniRef50_Q9RVG1 Probable 3-hydroxybutyryl-CoA dehydrogenase n=1934 Tax=root TaxID=1 RepID=HBD_DEIRA  ali  16  7.......................................................GAGQMGGGIAQVAAQSGFDVVVHDQKQEFLDRGKGVIEKSLGKLHEK-------------GKLTDAPETVLGIHFTTDLQD-FADCDLVVEAIVENQIKNDLFKQLGQIVKPEGILANTSSIPITALATASGRPA-------QFIGMHFMNP--VPLMQLVEVIRGYQTSDETARIVTETAEKLGKTPLSCN-DFPGFVSNRILMPMLNEAIQCVMEGVAMKLGMNHPMGPLTLADFIGLDTCLAIMEVLHQGLGDDKYRPSPLLRKMVQAGLLGR-KSGEGFYKY...... 278
28 1.000e-58UniRef50_H3A1I3 Hydroxyacyl-CoA dehydrogenase n=76 Tax=Opisthokonta TaxID=33154 RepID=H3A1I3_LATCH  ali  12  17...........................................AKKTIIKNIIVIGGGLMGSGIAQVAASTGHSVILVDQTDDILKKSMKGIEDSLKRIAKK-----KFADKPEAGAEFIQSTLK-NLTTSTDAASVVHSTDLVVEAIVENKVKHELFKKLDKFAPEHTIFANTSSLSITEIANSTTRQD-------RFGGLHFFNP--VPMMKLVEVIQTPMTSQKTYTALMDFSNAMGKQPVTC-KDTPGFIVNRLLVPYMMEAIRLEDIDLAMKLGAGYPMGPFELADYVGLDTSKYIIDGNELEPDNPLFAPSPLLNQLVEEGKLGR-KSGEGFYKY...... 308
29 1.000e-58UniRef50_A0A1N6ESN9 Prephenate dehydrogenase n=7 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A1N6ESN9_9BRAD  ali  16  18.......................................................................................GFGLIGGSIARGA-RLQGLAGEIVTTARSEKTRARVAELGIRVVATNAEAVKDADLVILCIPVGACGP-VAQEIAAFLKPGAIVSDVGSVKGAVVREM-------APYLPQGVHFVPAHPVAGTEHSGPDCILTPGADAGAVEKLRAFWAGLGARVEIMTPDHHDLVLAITSHLPHLIAYTIVGTADELEEVTSEVIKFS----AGGFRDFTRIAASDPMWRDVFLNNKDAVLEMLGTFNEAIRRNDGEALFEHFTRTR. 287
30 1.000e-58UniRef50_A0A212JU53 Protein TyrC n=482 Tax=root TaxID=1 RepID=A0A212JU53_9PROT  ali  15  30.....................................................................................................RRHGLAGRTLAAARRQETLDTALRLGIAASTDMASVVADADLVMVCVPVGA-TGAVMEAIAPHLKPGAIVSDVGSVKCAVIADVLPHL-------PEGVAFVPGHPLAGTEFSGPELTPLPHTPSDAVEKVAAMWRAVGSNVDTMDPEHHDRVLAITSHLPHLIAYTIVGTATDLGADLKEVIKYS----ASGFRDFTRIAASDPMWRDVFLNNKEAVLEVLQRF-----TEDLTALQRAIRRGE. 274
31 2.000e-58UniRef50_Q8THC2 Prephenate dehydrogenase n=72 Tax=Methanosarcinales TaxID=94695 RepID=Q8THC2_METAC  ali  11  17...................................................................................ILGGTGEMGQWFTRFFKERGYKVTVWGKGGK-----VEVARKLNVPFASELDAAIPENDIVIVSVPIN-VTEETIAEVAPKMKAGSLLMDFTSTKVKPVEAMQ-------RFAPAGVEILGTHPMFGPTIPGQTVILVPVRSEKWFPVIRQLFEEGGAHVEITTAAEHDRLVSVVQGLTHFAYISIGTTIDRLDFDIKKSRKFVSPVYSIMLDFVGRILGQNPLYALIQMENPEAFIEECEELSSLVRAHDEEGFVRKMKAAAR 279
32 2.000e-58UniRef50_T2MC83 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial n=5 Tax=Opisthokonta TaxID=33154 RepID=T2MC83_HYDVU  ali  13  21....................GSRLVNSTAKYCTTNDGKEKNISNVTVIGG-------GLMGAGIVQVAAQNDFDVVIVDKEDEYLQKCMVMVRKSIDRITKKKPKLASKFVNDTLNRIKTEKEPSVG----------VANADLVIEAITENDAKWKLFEVIDKAAPKHCIFTNTSSLPIFEISKVTSRPD-------KFGGLHFFNP--VPLMKLVEVVKAENTSQETFDTLFQFSKDLGKIPVAC-KDTPGFIVNRLLVPYMMEAIRFVEIDTAMKLGAGYPMGPFELADYVGLDTIKFIVDGWHKNNDNPLFNPSEMLNRCVEMGKFGK-KNGEGFYKY...... 328
33 3.000e-58UniRef50_A0A1E2UVK8 Prephenate dehydrogenase n=9 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A1E2UVK8_9GAMM  ali  14  3.................................................................................EKLAIIGVGLIGGSVAMALREEGKV-KEVVGCGRGEANLQKAQQLGVHYTHDVAQAVQGADMVLLAVPLGAI-RDTFEKMKGQLADHAVVTDAGSVKGSVVRDAEAVFQGVPDF------LVPGHPIAGTERSGVEVILTPLTRADAVQRVEQMWLDCGAEVSSMSVDHHDEVLAATSHLPHMLAYSLVDSLSRLKEN-DEIFRFA----AGGFRDFTRIASSNPMWRDICIANQQALADELHDLAALLEQGDADGLLSLFESAKQ 278
34 3.000e-58UniRef50_A0A2M7FA93 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=2 Tax=unclassified Nitrospirae TaxID=1298915 RepID=A0A2M7FA93_9  ali  13  5................................................................................FKRVVIIGVGLIGGSLA-LAGKKKGLFGEVIGVGRNKANLDAAVNMGARYVHDPKEVCKHADLMVLATPVERI-LSIGRETAPLMRKGACLTDVGSVKQAIVSGLDEIL-------PDGVHFVGGHPIAGSEESGAVLTPTRSTDPEALRKIRSLWEGVGSMVVEMDASEHDVILAAVSHLPHMAAYALVNTLSGMKDRHPSIPSFA----AGGFKDITRIAGSPEMWKEICRMNKKNILRALNSIQVKIEQDRFEELSRLFEQAR. 280
35 3.000e-58UniRef50_A0A1H4A0S5 Prephenate dehydrogenase n=5 Tax=Bacteria TaxID=2 RepID=A0A1H4A0S5_9GAMM  ali  15  4..................................................................................KLVIFGVGLIGGSLA-LALREANACETIVGCSRNAVHLQKAVDLGVSFSLDPAEAVCDADMVLLAVPMGAM-RHLLQQIKPTLPANAILTDAGSTKGSIVAEVAQVFGA------DFSRFVPGHPIAGREKSGVEVILTPHTDADAIAKVEAMWRVTGALLEQMPVELHDQVLAATSHLPHVLAFSLVDTLLNMPQR-EDILRYA----AGGFRDFTRIASSDPMWRDICLTNKAAILENLGEFAAMIDAQDGEALHNRMTRAKQ 278
36 3.000e-58UniRef50_A0A109B8X7 Cyclohexadienyl dehydrogenase n=164 Tax=root TaxID=1 RepID=A0A109B8X7_HYPSL  ali  13  23.......................................................................................GIGLIGSSISHAMRRG-GLAAEIVGSARTPATLETSLRLGLKGYASATEAVEGADLVILSVPVGACGP-ITAEIAPHLARGAILTDVGSVKAQVVRDMAPH-------VPAGVHFVPGHPIAGTEQSGPELTPTPDVDDAAVEKLRMFWEALGAKVEVMDPSHHDMVLAITSHLPHLIAFNIVNTAEDLGRVTDEVIKFS----AGGFRDFTRIAASDPMWRDIFLGNRDGVMEMLRRF-----SEDLDELKRAIEAGD. 280
37 3.000e-58UniRef50_A0A0F2IYP7 Prephenate dehydrogenase n=3 Tax=Nitrospiraceae TaxID=189779 RepID=A0A0F2IYP7_9BACT  ali  13  10.......................................................................................GVGLLGASIA-LALKEKKLTREIYGCGRQEERLKTACQIGIKYSLNYKDLCSDADLIILATPVGTF-RNIVEHITPHLKNGTILSDVGSVKGSLVYEIENSM-------PDDAYYVGAHPIAGSEKSGFEITPTDKTNKNALSTIKTLWETLGCNIIILSPQKHDAIFSSISHMPHIIAYALVNTIGEIDPDF---LKYSGR----GFIDTTRIASSSNLWRDICLLNKENIINNLDKLKSYIENSSSETLSEEIEKAR. 275
38 3.000e-58UniRef50_A0A2N1YL78 Bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase (Fragment) n=1 Tax=Gammaproteobacteria bacteri  ali  12  1...............................................................................MFNRVAIIGLGLIGGSLA-AAMRARGLAKTIVAGSRSERALERGKLLGLDGSTNLADAVKGADLVFLAVPVSSMA-DTMAQMAPGLSRTVIITDGGSVKGKVIDAAKQAIAGHLSR------FVPGHPIAGKEKSGVILTPTPHTDPAATAKVRALWTAVGAEVLSMQPDEHDRVLAETSHLPHLLAFSLVDTLARQGDSLD-IFRYA----AGGFRDFTRIASSDPMWHDIFKENRASVLQAVDLFSEG-----LDRFRSAVEQGD. 265
39 4.000e-58UniRef50_B5YH67 Prephenate dehydrogenase n=6 Tax=Thermodesulfovibrio TaxID=28261 RepID=B5YH67_THEYD  ali  12  1............................................................................MEDGFNTVSILGVGLIGGSLA-LALKEKKLVNKIIGYGRNEQRLKEALKLGISYTTSLKKA-SQAELIVLATP-AGIFEKIIIEMLNYLKKGTIIIDVGSVKESVVNSFEKIL-------PAGVFFVGTHPIAGSDKTGVIITPTENTDKSALEKVSNLWQKIGAVVEFMSADKHDKIYALVSHLPHLISFCMVNTVAEMDKNF---IKYAG----SGFKDTTRIASSPEVWRDIFIMNDKNILQCLE-----IFAKNLKEIKKMLSKKD. 264
40 6.000e-58UniRef50_B1L7P7 3-hydroxyacyl-CoA dehydrogenase NAD-binding n=1 Tax=Korarchaeum cryptofilum (strain OPF8) TaxID=374847 RepID=B1L7P7_KORCO  ali  15  7.......................................................GAGTMGHGIAQVAAMAGYEVYLRDVSDEFVQRGIERIRASLSKFLEK-------------GKISREEMESSRIHGTTDLGSAVKNVDFVIEAVPVFDIKAEIFREIDRIAPPNTVFTNTSSLPISELASVTSRPD-------RFVGMHFFNPPQL--MRLVEVVRGDRTSEETVRKTIELAKSMGKEPILVKKDVPGFIVNRILVRWLNEACLIAEIDSSLKGRAGLPMGAFELSDYIGLDVMRDIID............................................ 244
41 1.000e-57UniRef50_A0A066Q0I7 Protein TyrC n=46 Tax=Bacteria TaxID=2 RepID=A0A066Q0I7_9PROT  ali  15  13.......................................................................................GIGLIGSSIARVARERGDLARTIVANARTQATLDRVMELGIECEIDPARAVQGADCVIFCAPVGAYA-ALAEEIGPHLAPGAIVSDVGSTKQSVIRDIGPHL-------PEGVHFVPAHPMAGTEFSGPDLTPVPGTDQDAISRMRTFWERCGAMVSVMDAAHHDRVVAIVSHLPHLIAFTICGTADDLA---DETRQEVLQFAASGFRDFTRIAASDPMWRDVFLNNREALLEMLARF..................... 256
42 1.000e-57UniRef50_A0A0J5QDN8 Prephenate dehydrogenase n=307 Tax=root TaxID=1 RepID=A0A0J5QDN8_9RHOB  ali  15  30.....................................................................................................KRRGVAGSVSGYARSEATRDTARRIGLVVCDTAIAAVADADLVVLAVPVGAM-GAVAQQIGPHLKPGCTVTDVGSVKKTVIEAVAPHL-------PQGVHFVPGHPLAGTEHSGPELVPVEGTDPAALDRLRLYWERLGANVDVMDAEHHDLVLAVTSHTPHLIAYTMVGVADDLGRVTDEVIKYS----AAGFRDFTRIAASDPMWRDVFLNNKEATLEILGRFTEAIRTGDGDHLHDYFTRTR. 286
43 2.000e-57UniRef50_Q2Y6Y4 Prephenate dehydrogenase n=45 Tax=Proteobacteria TaxID=1224 RepID=Q2Y6Y4_NITMU  ali  15  27..................................................................................KLVVIGVGLIGGSFA-LALREAGRVQHITGIGRSRENMRRALALGDEIADNIESALKDAELVFLAVPVGQ-TGEIMAQISAYLAPSTIVTDAGSTKQEVVAAARSHLAPHLK------NFVPGHPVAGAERSGANVVLTPLTSREATQKVTELWEACGARISRMSANRHDEILAAVSHLPHVLAFALMNHVVSAGADGDAHDNDLLRFAGSGFRDSTRIASSPEMWRDICLGNRKALLNQIDAMREMLSDGDGDALERLFARAR. 307
44 2.000e-57UniRef50_G2DER2 Protein tyrC n=20 Tax=Gammaproteobacteria TaxID=1236 RepID=G2DER2_9GAMM  ali  14  3.................................................................................RKLAIIGVGLIGGSMARAL-RDEGVVQEIVGCGRNRENLEKAVALGVHYSHDVAVAVRGADLVLLAVPLGAMA-DTLRAMKGHLAEDAVVTDAGSVKGSVVRDAVEVFGEVPPF------FVPGHPIAGTERSGVEVILTPLTDQGALERVEWAWQKCGAVVTKMAVEHHDEVLAATSHLPHMLAFSLVDSLARMKEN-DEIFRYA----AGGFRDFTRIASSNPMWRDICIANQDALADELHEMAAVLKAGDSEALEQIFARAK. 277
45 2.000e-57UniRef50_A0A257MD18 Prephenate dehydrogenase n=1 Tax=Methanosaeta sp. NSP1 TaxID=1917472 RepID=A0A257MD18_9EURY  ali  14  37.......................................................................................................................VDVAERLGVRFAHDLMAEAKSSDIVLVSVTIEK-TVEVIRQVAPLMRPGSLIMDVTSIKSEPVQAMKS-------YAPVGVEALGTHPMFGPTMPGQTIILTPVKTGRWLAEISSLFQSDGANVEVLDAQEHDRIMAVVQALTHFAYIGIGATLKALQFDVSNSRRFMSPVYEIMIDFVGRILDQNPLYASIQK-NPQAFLSQCMRLCEKADSNDLEGFKQMMREAAE 267
46 2.000e-57UniRef50_A0A2H5UWI6 3-hydroxybutyryl-CoA dehydrogenase n=6 Tax=Archaea TaxID=2157 RepID=A0A2H5UWI6_9ARCH  ali  17  4....................................................LVVGAGVMGHGIAEVAALAGIDVVMVDVSDEFLAKGLERIRWSLDRFVEKK-------------KISREEADRARIATTTKLEEAAASADFAIEAVPEDELKRKIFQTLSRYCRPGVILTNTSTLPITEIAEATDRPD-------KVVGMHFFNPP--PLMPLVEVVLGEKTSPDTVNATVELGRRMGKHVIICRKDVPGFIVNRILAPLLNEAATVMEIDSAVKYRAGLPMGVFELADYSGIDVFYMAFNS........................................... 245
47 2.000e-57UniRef50_D4GX56 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase n=84 Tax=Halobacteria TaxID=183963 RepID=D4GX56_HALVD  ali  13  13.......................................................GAGNMGHGIAEVAALAGYDVVLRDIEDEFVQQGYDKIEWSLNKLAEK-----------DRLSQDDADAALARVSTAVDLGEAVADADVVIEAVPEMAIKKEVYAELEEYAPDHAVFTNTSSLSITELSEVTERPE-------RFCGMHFFNPPV--RMDLVEVISGAHTADETLDLVEDLAESMGKTPVRVRKDSPGFIVNRILVPLMNEAAWIVHAGDATKYDMGLPMGSFELADYVGIDVGYHVLEYMH-EVLGDAYEPCPLLSEKVEEGDLGQK............... 278
48 3.000e-57UniRef50_Q31GD3 Prephenate dehydrogenase n=17 Tax=root TaxID=1 RepID=Q31GD3_HYDCU  ali  13  5..................................................................................KMTIIGVGLIGGSFAKGIKKAQ-LCDQITGFGPDEKELQKAVELNVNYCLDLSSAVKDADLILLSVPLGAM-QSVLTDIKPFITDKTIITDVGSAKASVLSAVKNVFSKIP------ARFVAGHPIAGKEKSGVEVILTPETDKQAFEQVQHLWQALGADVSEMTPEFHDEVFAATSHLPHLLAFGLVNLL-NEHEELGNVFQYT----AGGFRDFTRIASSDAMWRDISMSNSQAIVKWLKNLITLVEEQKSDKIYDFFTQAKK 279
49 3.000e-57UniRef50_A0A240AWZ2 3-hydroxyacyl-CoA dehydrogenase n=38 Tax=cellular organisms TaxID=131567 RepID=A0A240AWZ2_CLOCO  ali  15  8.......................................................GAGTMGAGIAQAFAAKGYEVVLRDIKDEFVERGIKGIEKGLSK-------------RVSKGKMAQEDMDAIRIEGTVDLNKA-ADCDLVVEAAVEMKIKREIFAELDKICKPEAILSNTSSLSITEIATATNRPD-------KVIGMHFFNPA--PVMKLVEIIRGMATSQETFDAVKEVSIAIGKDPVEV-AEAPGFVVNRILIPMINEAVGIYAEGIATAEDIDHPMGPLALGDLIGLDVCLAIMDVLYTETGDTKYRAHSLLRKYVRAGWLGRK............... 272
50 4.000e-57UniRef50_U6EBN0 Putative arogenate/prephenate dehydrogenase n=7 Tax=Methanobacteriales TaxID=2158 RepID=U6EBN0_9EURY  ali  12  10........................................................................................RGLGNWIAKFLKNRGCQVTITGRNTFLGE---AIAHKMGVHYTSSNIQAASSAQVVIVAVPI-EFTPQTIKEVGPHLQEGSLLVDVTSVKELPAQTMQE-------AVPAGVEVLPTHPMFGPRIRGQVIVLTPQNRGKWYPKVVEFLKSEQVRILETTPEFHDRMMSIVQGLTHFAYIAIASTIEKMGVDVKESRKFSSPVYSLMLDMIARIVAQNPLYYSIQTQNRYTFLETINQLKSMIDGENQDGFVKAMSSAAK 267
51 4.000e-57UniRef50_S5T9E2 Prephenate dehydrogenase n=11 Tax=Bacteria TaxID=2 RepID=S5T9E2_9GAMM  ali  12  1...............................................................................MFKKMCIIGVGLIGGSIARASKK-NNLCEEVIGVGRSEKHLQKAVELGVIYELSIPLATKNADIIVICSPVGAF-ESIFQQLKTTWSKECLYTDAGSTKASVLDALENVFAGVPS------NFVPAHPIAGSENNGVELTPTESTDQQLTDLCQTWWEKMGAEVSIMSPRHHDEVFAATSHLPHVLAFSLVEVLKN-KQDEREIFEYA----AGGFKDFTRIASSDPMWADICLANGPELLNVMKELEQLIDAKDKQGLLEIFKSAQ. 277
52 4.000e-57UniRef50_A0A1X6VYW1 Arogenate dehydrogenase n=130 Tax=Bacteria TaxID=2 RepID=A0A1X6VYW1_CHLAO  ali  15  15.......................................................................................GVGLMGGSLALCFKGKPGL--RVVGHSPNPASVNKYLERGVEATTSFEQAACDADYIFLCVPVGQLEP-YLERLSNLLKPGCIITDVGSTKASVMDYARK-------LQFKDAYFIGGHPMAGSERSGVEYVLTPLTPEEVYGRLENLLRWTKAHVVRMDSGLHDDIVGAISHLPHIIAVALVNQIAAYNKD----NPYYERLAAGGFRDITRIASGDPMWRDILVHNRKVLLDLLKDW-----NRQMEHFVQLLEAAD. 271
53 4.000e-57UniRef50_A0A1F9YFD6 Uncharacterized protein n=1 Tax=Elusimicrobia bacterium RIFOXYD2_FULL_34_30 TaxID=1797974 RepID=A0A1F9YFD6_9BACT  ali  13  7.......................................................................................GVGLIGGSIGLALKKSRFKIKKIIGLGRNIKRLKIAQKLGAEFTTNFQKAVRNADIIFICFPV-ALIPSTVKKILPFCKKEAVITDVGSVKQSIVKEIENYIFSKNSSGPA---FIGGHPIAGSEKTSVKVVLTPTTSGKSLKKIKQIWENMNAKVRIMSPEKHDKILSFTSHLPHVIAFSLVNTVDNLEYT------------GGGFKDTTRIASSDRMWADIIWENRYSIRKFKQELLKIEKSKSKSEMLRIFRKAK. 269
54 5.000e-57UniRef50_S0G0E2 3-hydroxybutyryl-CoA dehydrogenase Hbd n=33 Tax=Bacteria TaxID=2 RepID=S0G0E2_9DELT  ali  14  1..............................................MEIKKICVLGAGIMGAGIAQVCAKAGFEVFIRDMEDRFVENGLTTIKSNLDRAVSKGKMDKDE-----------ADAVLGRITGTTDLTRAAGEADLVIEAIEVMDIKRQVFQDLDNICKKDTLITNTSGLSITEMAAVTQRPD-------KVIGMHFFNP--VPVMKLVELIRGFTTSDDTLNMAWEFVEKIDKTPIEV-KEAPGFAVNRILVPMINEAIFVLAEGVASAEDIDKSMGPLALSDMVGLDTILFVLEGFHRELGEDKYRPAPLLRKMVRAGYLGRK............... 275
55 6.000e-57UniRef50_D3S017 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein n=2 Tax=Archaeoglobaceae TaxID=2232 RepID=D3S017_FERPA  ali  17  1..............................................MEIKKVAVVGAGTMGSGIAQVCAMAGYEVWVRDISEEILNKAKETIEKNLRKAVNKGKISV-----------TKLKEIEAKLHFTTDLKEAVEDADLVIEAVPVMDLKKQVFKEICEYNKKAILATNTSGLSITELSKATDRPD-------KFVGMHFFNP--VPVMALVEVIKGEYTSEETVKIAVEFVKSLGKTPVVVKKDVTGFIVNRCLVPYLVLAIQDVENGVATKEEIDAPMGPIELSDFVGLDIL................................................. 241
56 6.000e-57UniRef50_A0A1F8WFV1 Uncharacterized protein n=1 Tax=Deltaproteobacteria bacterium GWA2_45_12 TaxID=1797805 RepID=A0A1F8WFV1_9DELT  ali  13  1...............................................................................MFQKVAILGVGLIGGSFG-LELKRRRLARQVVGVGRSKANLIQAKKLIDTIGVNLESSVRDADLVVLAGPVQAILRH-LKDIAPHLKKGAIVIDVGSTKQTIVDQASKKL-------PKHVFFVGTHPLAGTEKSGCLITPVATTHPVVLKKVMQVWQKMGAKTILVPPKEHDRLLAYTSHLPQVMATTLMNVISQ-GLPIETIKQFSG----GGFRDTTRIAASPEMWRDICFSNKPHLLKAIK-----IFQKELTKISNFLSKGKQ 265
57 6.000e-57UniRef50_A0A268J8A4 3-hydroxybutyryl-CoA dehydrogenase n=25 Tax=cellular organisms TaxID=131567 RepID=A0A268J8A4_9BACL  ali  14  1..............................................MAINNVMVIGAGQMGAGIAQVCAQSGFNVLLHDRDKNALQAGINGIEKLLARNVEK------------KRLTKEEKATTLGRLTPSHTLEDAATCDLIIEAVVEMDVKSAVFKEVDTHAPKHAILANTSSLPITEIAAETKRPD-------QVIGMHFMNP--VPVMKLVEIIRGLQTSDETYETIQMMTVQLSKTPVEV-KDFPGFVSNRILMPMINEAIYTVYEGVATPKDVDHPMGPLTLADFIGLDTCLYIMEVLHEGFGDSKYRPCPLLRQYVKAGWLGK-KSGKGFYEY...... 282
58 7.000e-57UniRef50_F2NIM7 Chorismate mutase n=1 Tax=Desulfobacca acetoxidans (strain ATCC 700848 / DSM 11109 / ASRB2) TaxID=880072 RepID=F2NIM7_DESAR  ali  13  5.........................................................................................................IGIIGGLGQMGRWFRRFFESQGLTVLPTCAEVAAQVDIVVISVP-LHLTEAVIRELAPHIRPEALLTDLTSLKQGPMAAMLDHFAG---------EVVGTHPLFGPGLEGQTIVVCPGRGDRWVPWLEDLYRQAGARLEVSTPEEHDRTMSLVQGLTHFTLITLGTTFRKLNADIDRMELLATPTFRAVYDQVYHLVNQNPLYAYIQLMNRQAFEEAVRQLRQIVLARDADALVQVLEENQR 253
59 8.000e-57UniRef50_A0A0C5VP63 Prephenate dehydrogenase n=1 Tax=Gynuella sunshinyii YC6258 TaxID=1445510 RepID=A0A0C5VP63_9GAMM  ali  15  1........................................................................MTVNLTDKN--LLVIGLGLIGGSLAKAC-RQNKIFASISGFSRKAETMSDALSLGLEVSDDLQALVSKADVIFLAVPILS-TPIVMAQIQPYLRNDTIVTDGGSVKGTVVKAGLELLTDAQLKM-----FVPGHPIAGSERSGVRIILTPETEPEAVQVVSQMWKSVGAEVDIMAWDYHDEVLAATSHLPHMLAFNLVDTLSKQSEN-REIFNYA----AGGFRDFTRIAASDPMWHDIFIANHRAILKVLDSFVFQEAKEAREHFSEILENRAR 298
60 8.000e-57UniRef50_A0A2E6P362 Prephenate dehydrogenase n=1 Tax=Acidiferrobacteraceae bacterium TaxID=2024893 RepID=A0A2E6P362_9GAMM  ali  16  27.....................................................................................................RYRGAVEEIVGYGRNIKNLGLAKELGLRWTTNIDEAVSHADIVLIATPVGAM-PAVFDLMKDAIAPECIITDVGSVKQVITEAFKNSF------LDQNVHFIPGHPIAGREVSGPTVILTPETDVDAISRVQELWQLVGSKVICMSPERHDRLLALTSHLPHVMAYTLVNLLKDEEDQQQDTLNFA----AGGFYDLSRIASSDPMWRDICLTNNNEIVSRLES-----YQNSLSHMIDILEAKD. 271
61 8.000e-57UniRef50_A0A1I5XQH0 Prephenate dehydrogenase n=3 Tax=Caldicoprobacter TaxID=715222 RepID=A0A1I5XQH0_9FIRM  ali  16  14.......................................................................................GLGLIGGSLAKAIRSHPDWQITGTDIEEKHLALALKEGVMDKGTTSLEEAVYNAQVIFVCAPVGAI-PGLIKEIAAHAPAGAIITDTGSTKEAIVRTAMECL-------PPGVFFVGGHPMAGTEHSGYVLTPLPSTPAWVINRLTSLLSSIGAIPLVMDPQLHDRIVGAISHLPHVVASALVNAVQE----IDDPQHFKERLAAGGFRDITRIASSSPMWRDISLSNRQRLVELIESTV-----RHLNAFCKYLDEGS. 270
62 9.000e-57UniRef50_A0A075WHK9 3-hydroxyacyl-CoA dehydrogenase n=22 Tax=Archaea TaxID=2157 RepID=A0A075WHK9_ARCFL  ali  16  14.......................................................GAGLMGHGIAEVCAMAGYNVTMRDIKQEFVDRGMNMIKESLAKLEQK-------------GKIKSAEEVLSRIKPTVDLEEAVKDADLVIEAVPVVEIKKQVWEEVDKLAKPDCIFTNTSTMRITMLADFTSRPE-------KFAGLHFFNPPVL--MRLVEVIRGEKTSDEVMDLLVEFVKSIGKTPVRVEKDVPGFIVNRVQAPASVLLMAILEKGIATPEEVDAPMGPFELVDYTGVDIL................................................. 243
63 1.000e-56UniRef50_A0A2E5ENP7 Uncharacterized protein n=1 Tax=Verrucomicrobiales bacterium TaxID=2026801 RepID=A0A2E5ENP7_9BACT  ali  18  55.....................................................................................................ARRKLAEKTAGYVRREASLVACRELVDEVTMDLEEAVRDADLIVLCTPLGQMKV-LAGQILPHLKPGAIVTDVGSVKGGVVAELEPLFSSA------GARFVGSHPMAGSEQSGCIVTHTPDTDAEALTAIETFWQSVGARTLCLAPDLHDDLTSRCSHLPHIVAAELANYVLSPVHPVEQAA-----LCATGFRDTTRIASSPEMWHDIVASNRKHLLRVLQEFYLALERNDMNAVIEFFKTAK. 310
64 1.000e-56UniRef50_A0A0S8ECW6 Uncharacterized protein n=1 Tax=Nitrospira bacterium SM23_35 TaxID=1704026 RepID=A0A0S8ECW6_9BACT  ali  11  3................................................................................FQNVTILGVGLIGASLA-LALKQYGLSKTVVGYGRTQGNLIRAQEQGISFESDPAKACNNADLIIFATPVG-VFIDIAKRISPVLQQNAIVIDVGSVKGGLVRDMERLLSPRGF-------FVGGHPIAGSDRSGIRCILTPTTDRDALEKIIAMWRTVGSLVTLMEPEEHDRIYAAVSHLPHLLAYELVNTV----EDINSSYLTFS---GQGFKDTTRIASQPELWRDICRHNRENLLAYLEA-----YKKNLDRVSHYLRDDD. 263
65 1.000e-56UniRef50_B3E444 Prephenate dehydrogenase n=3 Tax=Deltaproteobacteria TaxID=28221 RepID=B3E444_GEOLS  ali  14  13.......................................................................................GVGLIGGSFSRAL-KQAGVVKRVIGFDLDSANLAEALQLGVEIAADYAAAVSSADLVFLAVPVRAMTAAV-SACAPFLRPGCVVTDGGSVKDELVVACEQL-------VPAGCFFVGGHPIAGTEHSGRRCILTPTTDQQALDLVQRLWEAAGSRVECMEPLTHDRVFAAVSHLPHMVAYALVHAVNGSAEEEENILAFS----AGGFRDFTRIASSDPMWRDIALMNRLPLLAMLDR-----YQSEFAALRERVASGD. 269
66 1.000e-56UniRef50_A0A1V5R846 Putative 3-hydroxybutyryl-CoA dehydrogenase n=65 Tax=Bacteria TaxID=2 RepID=A0A1V5R846_9BACT  ali  17  7.......................................................GAGTMGSGIAQAFAVSGYQVIVRDLQQAFVDKGLAGIAKSLDRIVAKGNLSDED-----------RKAALGRLSGTTEL-SAAADVDLVIEAAVEMAIKKAVFAELDSVCKPEAILTNTSSLSITEIASATQRP-------HQVIGMHFFNP--VPMMKLVEVIKGLATSDETKATIVELCGTLGKTPVEVS-EAPGFVVNRILIPMINEAIGILDIDAAMKLGANHPIGPLALADLIGNDVNLAIMETLYQEFGDAKYRPHPLLRKMVRGGYLGKK............... 271
67 2.000e-56UniRef50_A6C5G9 Cyclohexadienyl dehydrogenase n=4 Tax=Gimesia TaxID=1649453 RepID=A6C5G9_9PLAN  ali  13  28.................................................................................................AAAARQRNLAETILGAGRNPSRMRAAQQSGLRGTTNIAETAAQSDLVIVCTPVNHI-VQFIQTVAQNCRPGTIITDVGSTKQQICDQLK-------GTLPGKVTFVASHPLAGSEKSGFEFVITPEESTEAVSKVRQFWEALGMHVLQTTPEKHDLILAETSHLPHVV------ASALAATLATENTRYTST----GFRDTTRIAGGDPLWIDILFSNRDAIVKSLDQFRDAIQNHDEKRLRQLLEEGKK 282
68 2.000e-56UniRef50_A0A2H0CCZ9 Prephenate dehydrogenase n=3 Tax=unclassified Candidatus Omnitrophica TaxID=1047005 RepID=A0A2H0CCZ9_9BACT  ali  15  1...............................................................................MFNRVTIIGLGLIGGSL-CLAIKEKRLAKEIVGVSRRKSTIDKAVKNRVAATLNLKDGVKDSDLVIITTPVFKIV-DIAKKIAPFLKKGAIVTDAGSTKKHIVENIEK-------ARLKDMDFVGSHPIAGSEKSGIKCIVTEAKNKSALNKVKKFWASIGMKVIVMPAQSHDKLLSKISHLPHALAVSLVNTAAGNGLDL----------AAGGFKDTTRIASEPELWQDIFLTNRGNLIR-----DINILKKELSKIEEVLKSNN. 257
69 2.000e-56UniRef50_A0A0P6HK22 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial n=3 Tax=Daphnia magna TaxID=35525 RepID=A0A0P6HK22_9CRUS  ali  11  142........................LLRTPYMMASFRRNLITSNSTQMAIKNVVVIGGGLMGSGIAQVAAQNGQNVTIVDLDQKVLDKAKNSINISLQRIAKKLFK-----DDSVKAEKFLSDSM-AHVTLSTNPEQAVNQSDLVVEAIVEKNIKQKLFQTLDAVAPTHTVFANTSSLPIGEIAQSTNRKD-------RFVGLHFFNP--VPVMKLLEVIRIPETSDDTYNLVMEWGKSIGKQTVTC-KDTPGFIVNRLLVPYMMEAVRLLERGDATARDIDTPMGPFELLDYVGLDTSKFIIEG---WAEKFPENPPTLNRLVEEGKLGMKTG--EGFYKY...... 452
70 2.000e-56UniRef50_A0A1F2PAA4 3-hydroxybutyryl-CoA dehydrogenase n=3 Tax=Archaea TaxID=2157 RepID=A0A1F2PAA4_9EURY  ali  13  15.........................................................GVMGNGIVQSCASAGYDVTVVDVSDEILERGLSNIKKSLGRFVKS-------------GKMTQDEADAIRITPTLNLEEAAKAADYVIEAVTEKEIKEEIFRKLDENCREGVILSNTSTLPIAALGAVTERPELV-------IGTHFMNPP--PLMKGVEIIRSIATSDETTEITNKFIESLGKVPIVV-KDSPGFITNRLLFILLNEAARIEDADTLLKLCFNWPMGPFELMDLIGLDTCVFVLDSIYKETGNPTYAPAPILREMRSGWLGRKSGR............. 281
71 2.000e-56UniRef50_Q61425 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial n=93 Tax=Amniota TaxID=32524 RepID=HCDH_MOUSE  ali  14  25.......................................ILIKHVTVIGG-------GLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKA-----GDEFVEKTLSC-LSTSTDAASVVHSTDLVVEAIVENKLKNELFQRLDKFAAEHTIFANTSSLQITNIANATTRQD-------RFAGLHFFNP--VPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSC-KDTPGFIVNRLLVPYLIEAVRLHERGDASKEDIDTPMGPFELLDYVGLDTTKFILDG---WHEMEPENP--LFQPSPSMNNLVAQKKL............ 302
72 2.000e-56UniRef50_A0A1V4MCV3 Uncharacterized protein n=2 Tax=Firmicutes bacterium ML8_F2 TaxID=1775675 RepID=A0A1V4MCV3_9FIRM  ali  13  11...............................................................................LFRQAALIGTGLIGGSIG-LALREKGLVGKIIGFDRDGVTCRKAREAVDLAVESPAEAVQDADLVILAVPVIS-AVEVLRELMPVIGRGTIITDVGSTKSAIMAAVEQIL-------PAGVSFIGGHPMAGSEESGIELTPAPGTSEQAVDKLSVLIDHIGAQPIVLDPLKHDRIVAMVSHLPHIAAASLVQSVAGTED-----MELVRTLAAGGFRDSTRIAGNPEIWRDICISNRWALLAALKSFKASINK............... 265
73 2.000e-56UniRef50_A0A259UJ53 Ketol-acid reductoisomerase n=6 Tax=Sporomusaceae TaxID=1843490 RepID=A0A259UJ53_9FIRM  ali  13  7..................................................................................RIAIIGMGLIGGSLGLAIKASQGEKVEVTGIDTNELSMLKAKQCGARITADYKTGIMSADMIFVCTPVLQIA-TLIKEIAPHLKQGAILTDTGSTKTYLIQEIAAAL-------PRGVHYVPGHPMAGREKSGIEYILTPTRDGDAVEAVRQVINWTGARVTEMNAAEHDWCTALISHVPHIGAAALVNLLTYLQDQENSIK-----LAGGGFRDTTRIASSNAMWADICMTNAGPIADSLDKFAAAVRQGDRDSIHKFFSNAKQ 281
74 2.000e-56UniRef50_O29237 3-hydroxyacyl-CoA dehydrogenase (Hbd-4) n=6 Tax=Archaeoglobus fulgidus TaxID=2234 RepID=O29237_ARCFU  ali  13  1..............................................MEIKTVAVLGAGLMGHGIAEVCAMAGYNVTMRDIKQEFVDRGMNMIKESLAKLEQK-------------GKIKSAEEVLSRIKPTVDLEEAVKDADLVIEAVPVVEIKKQVWEEVDKLAKPDCIFTNTSTMRITMLADFTSRPE-------KFAGLHFFNPPVL--MRLVEVIRGEKTSDEVMDLLVEFVKSIGKTPVRVEKDVPGFIANRVVAPRGVLLHAVVEAVDAAFRKAGYPMGPFELADYVGIDVAARYFARSPEY-----EPPERVRKMVEEGRLGRKTGR............. 275
75 2.000e-56UniRef50_A1ANP6 Prephenate dehydrogenase n=5 Tax=Bacteria TaxID=2 RepID=A1ANP6_PELPD  ali  13  4...............................................................................IIERLAIVGVGLIGGSFARAL-RQAGAVRHVVGIGRSRANLEHALSQGIEISFNATEGVAGAQLVFISIPVCSIS-AMVGAIAPSLAPGCIVTDGGSVKAEIVRECEKLI-------PEGCHFVGGHPIAGTENSGCILTPTERTDREAYETVARLWRVAGANVCSMDPERHDRILAEISHLPHAVAYALVHAVGTADAEGENVLSYS----AGGFRDFTRIASSDPMWRDIALMNRRALLASIDGFSA-----SLAELRRRIDSGD. 268
76 2.000e-56UniRef50_A0A1Q6DSK5 Prephenate dehydrogenase TyrA n=1 Tax=Candidatus Methanohalarchaeum thermophilum TaxID=1903181 RepID=A0A1Q6DSK5_9EURY  ali  11  11......................................................................................KMGEWIANYLSNHPRKFD-LVIQDLNKQKGE---KIAKETNAKFHTEYSDFIPEMDVVVVCVPIDSISK-VIKEISPHMKEGSLLMDIGSVKTEPIKTMKQ-------LKNKKISLIGTHPLFGPEPKNQNIVLVPIKKDKWFNKLKTFLKENGFNVEVMSAKDHDKKMAIIQGLTHFLVIVFGKTLQENGFNLKESTKFSTPTYQLFVENLKRVFVQNPLYAQIQLHNPYTFLKEFKEGREYIKDENLQDLIDYISEGER 269
77 3.000e-56UniRef50_H6Q8Z6 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=Pyrobaculum oguniense (strain DSM 13380 / JCM 10595 / TE7) TaxID=698757 RepID=H6Q8Z6_PYROT :_  ali  10  1................................................MLKVLVVGAGTMGHGIAQVAAMAGHHVYLHDISPEALEKALAKIRWSLEKLKE-------------RGAVSSIESVLSRIEPAKSLEGVARDADIAIEAVPEDSIKKEVFKILDKAMRPDVVLTNTSSLPISEIASATARPQRVL-------GLHFFNPPVL--MKLVEVVRGDATDALMLEKALDFVKSLRKTPILVKKDVPGFVVNRILHAIHLVAYSVVEVDSALKHRAGLPMGIFELRDFSGIDVGYMVAKSLA-ERDILFSQLCPLLERLYKQGLLG-VKSGEGFYKYTAQGQR 285
78 3.000e-56UniRef50_A0A1X9N6P0 Prephenate dehydrogenase n=1 Tax=Oceanicoccus sagamiensis TaxID=716816 RepID=A0A1X9N6P0_9GAMM  ali  14  1............................................................................MTIAIDQITILAVGLIGGSLAKAL-KANGFSGEIVGWGRREVSLKKGLELGVRYSLDLNEAVKGADLIVVATPTL-IAADMIKQLVSMVDEHVIITDVASVKGNLLVAAKQAFGKVPP------NLVLGHPIAGSEQSGVRVILTPTTNPDALQAVKSLWESTGADLVEMPVDEHDEVLAATSHLPHILAYTLVDALAGNPEQQN-IFRFA----AGGFRDFTRIASSDPMWHEISLANRDALLKMIDTF-----SDQLGDLRQAIADGD. 268
79 3.000e-56UniRef50_Q16836 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial n=111 Tax=Amniota TaxID=32524 RepID=HCDH_HUMAN  ali  13  23.....................................KKIIVKHVTVIGG-------GLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKK-----KFAENLKAGDEFVEKTLST-IATSTDAASVVHSTDLVVEAIVENKVKNELFKRLDKFAAEHTIFANTSSLQITSIANATTRQD-------RFAGLHFFNP--VPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSC-KDTPGFIVNRLLVPYLMEAIRLYERGDASKEDIDTPMGPFELLDYVGLDTTKFIVDGWEMDAENPLHQPSPSLNKLVAENKFGKK............... 305
80 3.000e-56UniRef50_A0A0N8DJA4 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial n=27 Tax=Bilateria TaxID=33213 RepID=A0A0N8DJA4_9CRUS  ali  11  36........................LLRTPYMMASFRRNLITSNSTQMAIKNVVVIGGGLMGSGIAQVAAQNGQNVTIVDLDQKVLDKAKNSINISLQRIAKKLFK-----DDSVKAEKFLSDSM-AHVTLSTNPEQAVNQSDLVVEAIVEKNIKQKLFQTLDAVAPTHTVFANTSSLPIGEIAQSTNRKD-------RFVGLHFFNP--VPVMKLLEVIRIPETSDDTYNLVMEWGKSIGKQTVTC-KDTPGFIVNRLLVPYMMEAVRLLERGDATARDIDTPMGPFELLDYVGLDTSKFIIEG---WAEKFPENPPTLNRLVEEGKLGMKTG--EGFYKY...... 346
81 3.000e-56UniRef50_A0A1D2WB00 Prephenate dehydrogenase n=3 Tax=Methanobacteriaceae TaxID=2159 RepID=A0A1D2WB00_9EURY  ali  14  16..................................................................................................IARFLKSKGFDITVTGRDEIAGERVKKLGVNYTCSNTIAASQADIIIVSVPI-DVTSSAIKEVAPVMKKGSLIMDVTSVKEEPSRIMQE-------YVPHDVEVLPIHPMFGPRIRGQVIVVTPTNRGKWYNKVYNFFEKENARIIVTTPEIHDQMMSVVQGLTHLAYISIAATIEKLDVDIKESRNFASPIYDLMVDMIARIVAQNPLYYSIQTHNKYTFISIYKELNEMISSGNEEGFVKVMGSAAK 267
82 3.000e-56UniRef50_A0A2E9B806 Uncharacterized protein n=7 Tax=Rhizobiales TaxID=356 RepID=A0A2E9B806_9RHIZ  ali  15  4............................................................................ENIIFDTVAIVGIGLIGSSIARGIQK-NKIARNVFGYAKTDSTRAKARELGYKIFDTLVETVNDADLIILCAPVGS-NAEIMRNIQGHLKKGSIITDVGSVKKAVIDQIDKYL-------PDGVSFIPGHPIAGTEFSGPECLLTPYTDTDKVDKVVFFWEELGMFVDIMSPEMHDLVLATISHLPHLVAFNLVDTASKLENKKNYEV---TKYAAGGFLDYTRVASSDPMWRDVFLNNKDAVIEILDSFIDGLA--DLKDSIK-MENGNK 275
83 4.000e-56UniRef50_L0DWY5 Cyclohexadienyl dehydrogenase n=14 Tax=Proteobacteria TaxID=1224 RepID=L0DWY5_THIND  ali  12  3.................................................................................QRLVIFGVGLIGGSLA-LALREAGAVGEVVGCSRNPENLEEAQRLGVRWTTDPVEACRDAEVGVLAVPLGSM-QGLAAALAGHWPKDALLTDVGSSKQAVIDAVRSGFGQLPR------NFVAGHPIAGTEKSGVAVILTPETNPIAADRIGAMWRAAGARVEFMTPGHHDHVLAATSHLPHVLAFALVESLARLSES-DEIFHYA----AGGFRDFTRIASSDPVWRDICVANRDAILEVLERF-----QRDLDSLREVIVRGD. 265
84 4.000e-56UniRef50_A0A0G3W7V4 Prephenate dehydrogenase TyrA n=4 Tax=Clostridiaceae TaxID=31979 RepID=A0A0G3W7V4_9CLOT  ali  13  4................................................................................FQRIVIIGMGLIGGSLALALKKS-GFTGEIIGYDVSKDTLEEAKILGAIDTTDPKEAVKKADLVVMAVPVGYYA-EIFREVAPFLSEDVVVTDVGSVKGYVEDVVDAYL-------PKEIQFLGGHPMAGSEKGGIFLTPNKNTRKDTIEALEILIKGIGAFPVVVAADEHDKIVAQISHMPHLVAVLLANTLDRRNSIS------YTPFVGGGFRDTTRIAANPHMWRDIFFYNQEVLEVMLKEFREILCQEKSEEVLDTLKKAK. 277
85 5.000e-56UniRef50_Q1H2E5 Prephenate dehydrogenase n=3 Tax=root TaxID=1 RepID=Q1H2E5_METFK  ali  13  3..................................................................................KLLVFGVGLIGGSLALALKAANK-DWHVTGIGRTGDSLQEALALGIEAASDPVTALKDVDVVMIATPVAQIA-SILERIAPHLEENTIVTDAGSTKAEIVEQAHRILGEAASR------FVPGHPIAGAEKSGVILTPCAHTDPAAIQAIHELWLSTGAIVRQMSPAEHDTVFAAVSHLPHLLAFALVDELAA-RPDADQFFEFA----ASGFRDFTRIASSPEMWRDISLANRTALLQELDRLRQTLEQGNAASLQAIFERAS. 276
86 5.000e-56UniRef50_A0A131XLW9 Putative 3-hydroxyacyl-coa dehydrogenase n=19 Tax=Bilateria TaxID=33213 RepID=A0A131XLW9_9ACAR  ali  13  32...........................................................MGAGIAQVASQTGHQVVLVDVSKEVLEKSRARIEESVKRVAKK------KFVDDKKEREEFVQKTLSGIALSTSADEAVKNTDLVVEAIVENDVKKKLFAAIDKTAGPSTIFANTSSLPIAEIASSTSRKD-------RFGGLHFFNP--VPVMKLLEVVRIPETSEDTFQKMQAWGKALGKTTVVC-KDTPGFIVNRLLVPSLMEAIRMLERGDASAQDIDHPMGPFELTDYVGLDVTKFIIDGWHEFPDNPLFKPSPFLDKLQEGKLGIKSGE............. 302
87 5.000e-56UniRef50_A0A1N6NFF4 3-phosphoshikimate 1-carboxyvinyltransferase n=6 Tax=Oceanospirillaceae TaxID=135620 RepID=A0A1N6NFF4_9GAMM  ali  15  14..................................................................................RVLVIGLGLIGGSFAKAL-KTRSCVEEVVGADRNPDECRLGLDLGVRVAEDLAAEVGLADLIVLAVPVKAM-EKVLAEIKPHLRLQTLVTDVGSTKTNLVTAARAIFGRLPPT------FIPGHPIAGAEKSGVKLILTPLTDPDATLELARLWQAVGAEVLQMEVERHDEVLAATSHLPHLLAFSLVDTLAREEENLD-IFRYA----AGGFRDFTRIAASDPMWHDICIANREAILAQIDRLRAAVDSGDSETLLGIFTRAK. 287
88 6.000e-56UniRef50_UPI000556D7E4 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Clostridiales bacterium DRI-13 TaxID=1449126 RepID=UPI  ali  15  3.................................................................................RNITIIGLGVIGGSLGALKKKKPEIKVCGIDTRQEVLGEAVARKAIDWGTLHFEAAVRDAEVIFLATP-MTAMPVVCQEIVPFLKPGTIITDVGSTKRYIVNTLQEIL-------PPTVQFVGGHPMAGSEKGGLILTPTLKTSSNAMETVKQLVQDVGAKVILLSPEEHDRKVAAVSHLPHLVASALVSTVGELEE---REKGYFAL-AAGGFRDSTRIAASNEMWCDIFLQNEKALLESLERLEKYIEEKNAQALLEMLRQSR. 277
89 6.000e-56UniRef50_A0A1R1YMP6 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial n=5 Tax=Smittium TaxID=4888 RepID=A0A1R1YMP6_9FUNG  ali  14  35..........................................TKQTSPFEKVTVFGAGLMGAGIAQVSAMSNHQVQLVDVSEDAINKGQTYILKSLKRIAKK------KFPESQPEQISFTENIYSKIDFSTNPELAVSNADLVVEAVIENDIKRKIFTQLDAVAPKHTIFTNTSSLPIADIFSVV-----PETRQASTAGLHFFNP--VSQMKLVEIVKSNATSTDTYDKLTSFCLALGKAPVTC-KDTPGFIVNRLLVPYMMEAIRMLERGDASAKDIDTPMGPFELLDYVGLDTVKFITSYPELRASGIASPSKMLDDLVSSGKLGVKSG--EGFYSYAKKA.. 336
90 6.000e-56UniRef50_A0A256Z535 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Candidatus Bathyarchaeota archaeon ex4484_231 TaxID=2012512 RepID=A0A256Z535_9ARCH  ali  14  11.......................................................GAGMMGHGIAQVFAMKGYEVNLLDISDEILKKAVEGIQWSLNKFVEKRRIRKED-----------ADAALSRIKTTTAYEDAAKDIDFAIEAVSENDLKKKVFAKIDEFAPPHAMITNTSTLSITEMGRATKRPD-------KAVGMHWFNPPQL--MQLIEVIKGDDTSDETVNTVLDLSKKLGKTPILCKKDVRGFIVNRILGCVFNEAFWAYHRGEASKEGIDAPMGWFELCDFVGVDIA................................................. 243
91 8.000e-56UniRef50_A0A2E6BLQ2 Uncharacterized protein n=4 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A2E6BLQ2_9RICK  ali  12  11.......................................................................................GMGLINSSLARSLKK-KKFYEYAIAISRRKSTIQKIQELKIHVEINYKKAVKNADLIIIGIPVNAYV-EVLEKIKDYLKPGVILTDVGSVKRNIIKEVNKKL-------PNTVSFIPGHPIAGTENSGPECILTPEKDKKALKLVKNMWLQVGMKVDIMDSLHHDMVLAITSHIPHIIAYSIVGTVANLEKSLKEVIKYA----ASGFRDFTRIAASDPMWRDILIMNKNSILQMLE-----IFKNDLQQLENAIKRND. 268
92 8.000e-56UniRef50_A0A1M4MPX1 Prephenate dehydrogenase n=1 Tax=Methanothermobacter wolfeii TaxID=145261 RepID=A0A1M4MPX1_METWO  ali  13  21.....................................................................................................KDEGFSVIITGRDR-EAGLAAAERIGADYCPDNTRAASASDVVIVSVPI-DVTPNVLREVAPNVREGCLLMDVTSVKEEPARIMAELI-------PDGAYFIPAHPMFGPSLEGQVVVLTPTEDNPWLEPLKEFLEERKARVIVTDPEKHDLMMAVVQVLTHFAYISIAATLESAGVDIRESRKFASPIYNLMIDTIARIVAQNPLAYSIQTHNRHAFLETAGELRDLLDSGAMDEFVRRMSLAAK 267
93 9.000e-56UniRef50_E0IC69 Prephenate dehydrogenase n=121 Tax=Bacillales TaxID=1385 RepID=E0IC69_9BACL  ali  15  8.......................................................................................GVGLMGGSLALCFKGKSDLHVVGHSTRLSSVHKYIERGVVDAATTSLREAAEDADFIFLCVPVGSLN-DYLEQLSELLKPGCIITDVGSTKSSVTACARRLDLSPAV-------FIGGHPMAGSERSGVEYVITPATPNEAVERLRQLLELTKANVVVVDADEHDDIVGAISHLPHMIAVALTNQVRKYNED----NSLYSQLAAGGFRDITRIASSDPVWRDILVNNREVMLRLIKDWNEGIQQGDIEGIGEAFR.... 273
94 9.000e-56UniRef50_A0A162UHK5 Protein tyrC n=12 Tax=unclassified Gammaproteobacteria TaxID=118884 RepID=A0A162UHK5_9GAMM  ali  16  12.................................................................................DRVTIVGIGLIGGSLARALKKNNAVG-TVVAYDVNVDALEKAKALGVEVTTDLAEAVKDSDIIIMATPI-TVMGRLVKEMLPHLKEDAIVSDVGSTKGSVIRTITEAVGYLPKR------FVPAHPIAGTEKHGVEIIPHINNNHGAVTTLTKMWESVGSIVEEMGVVHHDQVLAATSHIPHLLAYSTVDTLANL-DDRAEIFRFA----AGGFRDFTRITSNPEMWTDICLENREAVLQVLRAYLEALDKEDRETILEIFSRAK. 286
95 1.000e-55UniRef50_A0A1G1ITJ5 Uncharacterized protein (Fragment) n=1 Tax=Nitrospirae bacterium RIFCSPHIGHO2_02_FULL_40_19 TaxID=1801713 RepID=A0A1G1ITJ5_9BACT  ali  19  1...........................................................................................................................KDLGVEFSTEPAEGVKDADLILLATPVGQFS-EIIEGIRNHIKPGSIVTDVGSVKAKVIKELKKLM-------PKGVSFVGAHPIAGKECSGVNITPDENTDKTALEKVFELWNTLGAKTVLMSPDEHDAIFAAVSHLPHVLAYVLINAIMDLNETI-------LPHGGRGLRDMTRIALSPPLWRDICHYNKEHILKSLDCF..................... 204
96 1.000e-55UniRef50_F0S375 Prephenate dehydrogenase n=5 Tax=Desulfurobacteriaceae TaxID=558314 RepID=F0S375_DESTD  ali  12  5................................................................................FKEICIVGLGLIGGSFA-LNLKHKGYSGKITAVDINPKAVEEGLKLGVIDSSTNYSIAKSADLIVLAVPVG-VYRQVLDQLKPYISKGTVVSDLGSVKGHLVYMCEEFLKGLAP-------FVGGHPIAGTEKSGVEVTPTENTDKKALEKIVSLWKSLGSQVVEMDPFYHDQVFAAVSHLPHLVAYSIVDAIAKLSEDLKTLFQFTG----GGFKDFTRIAMSDPMWRDICIENKENLLK.......................... 248
97 1.000e-55UniRef50_A0A2H5V236 3-hydroxybutyryl-CoA dehydrogenase n=3 Tax=Archaea TaxID=2157 RepID=A0A2H5V236_9ARCH  ali  14  12.......................................................GAGMMGHGIAQVFAMRGYEVNLLDISEDILRKAMQNIEWSLGKFVEKKRIRRED-----------ADAALSRIKPTISYEAGVGNVDLVIEAVPEMDLKKKIFSTVDKIAPPHAIVSNTSTLSISEMGEATSRPD-------KVAGMHWFNPPQL--MNLIEVVKGDKTSQETIDKIIALSKALGKTPILCKKDARGFIVNRVLGAYHRGEASMEGIDASIKYTGGFPMGWFELCDFVGLDIA................................................. 244
98 1.000e-55UniRef50_A0A177QDM6 Uncharacterized protein n=27 Tax=Nitrospirae TaxID=40117 RepID=A0A177QDM6_9BACT  ali  12  12.......................................................................................GVGLIGGSLGMILRR-KGLAERVIGVGRRVENLKAAVELGARYVVDPKDGVRDADLVVLATPVDTYDRH-LREWASCLKKGAIVTDVGSVKGLLVEQAEQAM-------PAGVHFVGAHPIAGKEKTGVIMTPTKTTDPQALEQVRTMWQETGSVVLTMDAHLHDKILGAVSHLPHVAAFALINALAEIRDQQLPALDLASHSG-GGLRDTTRIASSPEMWRDIFLWNREAYERSLSQLKQLIRVGD............. 271
99 1.000e-55UniRef50_L7IV97 3-hydroxybutyryl-CoA dehydrogenase n=4 Tax=leotiomyceta TaxID=716546 RepID=L7IV97_MAGOP  ali  16  198........................................CFSSTPSRGAAEVKKLAGQMGLGIALVAARAQVPVTLVDPSQGALDKGLSLADKLLSK-------------DLQKSRISQEDADATRGRLSTTSMDSLADVDFVIEAVPIPNLKYEIFSKLAQICPKHAILTNTSSISITRIAAATTKDATDLSASSRVVSTHFMNP--VPVMKGVEIISGLQTSQETLDTAVAFCKAMGKVP-STSADSPGFLANRILMPYINEAVICLETDTIMKTGTNVPMGPLQLADFIGLDTCLAIMKVLHTETGDSKYRPSVLLQKMVDAGWLGKK............... 489
100 1.000e-55UniRef50_A0A2H6F8V0 Prephenate dehydrogenase n=1 Tax=bacterium BMS3Abin07 TaxID=2005715 RepID=A0A2H6F8V0_9BACT  ali  14  10.......................................................................................GVGLIGASFA-LALRHNGICTEIDGSGRTEDNLLRAREAGIHYFMDHARACKDADLVVLATPVGCF-EGIMSEIRDVLKKGTIITDVGSTKGEIVEILE-------REIPEGVSFVGAHPIAGSDRSGIEITPTESSRHESLKTIGELWKQIGARVIMMPPDEHDRIFSSVSHVPHITAYAIIKTLSDINPSY-------INMSGQGFRDTTRIASSPEMWIDVCRSNRDILIKNLESIKRLIENNDYDQLRSLLNDAKE 276
101 1.000e-55UniRef50_A0A2J6H0B3 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Candidatus Woesearchaeota archaeon TaxID=2026803 RepID=A0  ali  12  11.........................................................................................................IGVIGGKGAMGKLFADAFTDLGIDTEITNKELASNSDIIIISVPIRK-TREVIREIVPFVKKGSLLTDLTSVKEMPVEEMTKA---------KDCEVVGGHPLFGPGLKNQNFIICKERTGEIYKEYISLLERLGIKIIYMSVAEHDMQMGVIQGLTHFSNITLGNTLQNIGYDIEKGESISSPVYLMRLYGVGRILDQDPLYSDIQIENKYAYVESSKQICDAVNAKDKESFEKIFNKSKD 258
102 1.000e-55UniRef50_C0GG09 Prephenate dehydrogenase n=1 Tax=Dethiobacter alkaliphilus AHT 1 TaxID=555088 RepID=C0GG09_9FIRM  ali  13  1............................................................................MGFIFERAALVGVGMVGGSLGRAM-LGRGLVKDVVGID--PASADKALELGAETAATLKEGVAHADLVVLAAPVMAV-LELLPQLASLLKGGAVVTDVSSTKAMVMDKAAEVL-------PGSVTFVGGHPMAGSEKDGVEYVLTYGAGDSQGDRVATLVEKLGAVPVKMDAGQHDRVVASVSHLPHMAASALAETVAANDEDRERIM----TLAASGFRDTTRVAGSPQMWRDICLTNQEHIIKELTEVRDLVASGDGTGLLEHFERARD 277
103 2.000e-55UniRef50_W9V3Y9 3-phosphoshikimate 1-carboxyvinyltransferase n=2 Tax=Nitrincola TaxID=267849 RepID=W9V3Y9_9GAMM  ali  13  20..............................................................................................SFAKAL-KSRKVVQHVAAYDRHPQECDLGMRLGVEAVEDLPSAVQQADVIVLAVPVKAM-EAVLKDIQPFLRPTTLLTDVGSTKGHLVQAVRQVFQQIPS------GFVPGHPIAGAEKSGVKVILTPLSDPKATLEVARLWQSVGAEVLQMDPYRHDQVLAATSHLPHVLAFSLVDTLAHEEENRD-IFRYA----AGGFRDFTRIAASDPMWHDICQANRDAILKQIDRLRSAIAAGDSQAMLGIFSRAK. 281
104 2.000e-55UniRef50_A0A2H2I5C0 Uncharacterized protein n=1 Tax=Caenorhabditis japonica TaxID=281687 RepID=A0A2H2I5C0_CAEJA  ali  16  312.......................................................GSGLMGSGIAQISASSGFNVTLIDVKKEVLERAMKSINSSLKRVAKKQSG----GGAVNSDFASLSMA---RIKTSENVSSAVADADLIIEAAVENDLKKGLFAQIEQASKPTAILTNTSSLR-------LENICKAIDDKTRFAGLHFFNP--VPVMKLLEVVRTEETSDETYATLIKFGKAIGKTTVSC-KDSPGFIVNRLLIPYCFEAASMTDIDSAMKLGAGYPMGPFELMDYVGLDTLKFVMDGWAEYPDNPLFAASPLLDALVSEGKLGRK............... 582
105 2.000e-55UniRef50_L9WMJ0 3-hydroxyacyl-CoA dehydrogenase (Fragment) n=12 Tax=Halobacteria TaxID=183963 RepID=L9WMJ0_9EURY  ali  14  13.......................................................GAGSMGHGIAEVAAIGGYDVTMRDIEDDLVQDGYDNIEWSVEKLAEKGQ--------IDESAETVLD----RVETTTDLADAVSDADLVIEAVPEQEIKEDTFSTVDEHAPDHAILANTSSLSISDIASATDRPD-------QVVGLHFFNPPV--KMDLVEVTYGEATSDETAEAAYEWAESVDKTPIYVRKDVHGFVVNTVLVPFMEEAAWMLEADASMVYKRGYPMGPFELNDFGGIDIAYRDASGQPV--------PPAIEEKVENDNLGNKSG.............. 273
106 2.000e-55UniRef50_P07023 T-protein n=1265 Tax=root TaxID=1 RepID=TYRA_ECOLI  ali  13  13................................DEVDKALLNLLAKRLELVAEVGEVKSRFGLPIYVPEREASMDLIEDVLRRVMRESYSSENDKGFKTLCPSLRPVVIVGGGGQMGRLFEKMLTLSGYQVRDRAADIVADAGMVIVSVPI-HVTEQVIGKLPP-LPKDCILVDLASVKNGPLQAMLVAHDGP---------VLGLHPMFGPDLAKQVVVWCDGRKPEAYQWFLEQIQVWGARLHRISAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPLYADI-------IMSSERNLALIKRYKRFGEAIELLEQGDK 336
107 2.000e-55UniRef50_A0A1H3GTN0 Molybdopterin-guanine dinucleotide biosynthesis protein MobB n=1 Tax=Allochromatium warmingii TaxID=61595 RepID=A0A1H3GTN0_ALLWA  ali  16  28..........................................................................................................VGEIVGCGRSLANLERARALGVHITHDPAEAVRGADLVFLAVPLGAM-RGALAAMRDSLDPEAIITDGGSVKCSVIEDARAVFGAVPPR------LVPGHPIAGTEHSGVEVILTPLTDPDALARVTAMWQACGAEVTEMSVAHHDEVLAATSHLPHMLAFGLVDALARMREN-DEIFRYA----AGGFRDFTRIASSNPMWRDICLANREALSAMLARFAESIRRADGEQLHEIF..... 274
108 4.000e-55UniRef50_Q0CU98 Uncharacterized protein n=1 Tax=Aspergillus terreus (strain NIH 2624 / FGSC A1156) TaxID=341663 RepID=Q0CU98_ASPTN  ali  16  20........................................SFSTTSAAHAAEVKSLAGQMGLGIALVAAQAQVPVTLIDNSQASLDKGLKFADKLLEK-------------DVSKERITRDAADAARSRITTSLKDDLSSVDFVIEAVPIPDLKTSIFSKLAQVAPKHAILTNTSSISITKIAAATTTDPTDLQAPSRVISTHFMNP--VPVQKGVEIISGLQTSKETLDTAIAFVERMGK-VASISADSPGFLANRILMPYINEAIICLETGVGGREDIDNPMGPLTLADFIGLDTCLAIMNVLHQETGDSKYRPSGLLKRMVDAGWMGKK............... 311
109 4.000e-55UniRef50_A0A2D4S9H3 Prephenate dehydrogenase n=11 Tax=Bacteria TaxID=2 RepID=A0A2D4S9H3_9GAMM  ali  15  12................................................................................FERVAIIGVGLIGGSFA-LALKQQRLAGHITGCGRNAEHLARGVALGVDYSTSVQEAVRGADLVLLAMPVGA-SQAVFEAMAGQLAPETIITDAGSTKASVIRAAQAAFGAVPPR------FVPGHPVAGTEQSGVEVILTPLTDMQAVSAVRALWQAVGADVVDMDADHHDEVLAATSHLPHLLAYSLVDTLARMAER-REVFEYA----AGGFADFSRIASSSPMWVDIAEGNRDALLSVLDRLRADIDNGRWAEVRQLFARAK. 287
110 5.000e-55UniRef50_K1PLM3 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial n=31 Tax=cellular organisms TaxID=131567 RepID=K1PLM3_CRAGI  ali  13  7.......................SFVRSFATSAQRAN---AFNHVTVIGG-------GLMGSGIAQVAASTGHTVSLVDQDNTILGKSMNGIHKSLERVAKKKFENPAAGEAFVKDTM-------GRISTATSPITCVSHTDLVIEAIVENETKKKLFRELEAVAPEHTIFTNTSSIPITDIAVAAKRKD-------RFGGLHFFNP--VPMMKLLEVIRIPATSDATFDKLLAFGKDMEKVTVSC-KDTPGFIVNRLLVPYMLEAVRMVERGDAMKLGAGYPMGPFELSDYVGLDTMKFILDGWSKYPDNPLFKPSSLLDKMVAQGKLGRK............... 299
111 5.000e-55UniRef50_A0A1G1JUX1 Uncharacterized protein n=4 Tax=unclassified Candidatus Omnitrophica TaxID=1047005 RepID=A0A1G1JUX1_9BACT  ali  11  11.......................................................................................GVGLIGGSIGLAIKK-RRLSKDVIGVFRRGSTLRKALKAVDWGTMDMKEGVSDADLVILATPVASI-PSVAGQVIKLAKEGAVITDVGSTKRWIVENVERHL----RRGARAVYFVGSHPMAGSERTSVEVTKTKRTNTRALGAVINFWSSLGAKVTAMSPVEHDRVAAFISHLPHLVSFSLAGTVADKYISYG----------AEGFGDTTRVASSDPLWADIFLTNKEEILRSCRLFEKALSRGDRSRIIKMLKTAK. 276
112 5.000e-55UniRef50_A0A2P6C5D8 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Salinibacter sp. 10B TaxID=1923971 RepID=A0A2P6C5D8_9BACT  ali  15  11.......................................................GAGTMGNGIAHVFALHGHDVTLIDVDQDRLDAAVTTIEENLNRQVDKDK------IGSGEREEALD-----RLQTTTDTAEGVADVGLAVEAVPEQELKAEIFGTLDRHAPDDAILANTSSISITWIAAQTERPA-------RVIGMHFFNP--VPVMTLVEVVRGQRTSEATFDTVSGLAEELDKKPVEVE-DYPGFVSNRVLMPMINEAVFCVMEGVADPDDIDHPMGPLTLADFIGLDVCLHIMEVLHEELGDDKYRPCPLLRRKVTAGQLGRK............... 276
113 7.000e-55UniRef50_A0A1Y5EJ42 Prephenate dehydrogenase n=2 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A1Y5EJ42_9GAMM  ali  13  9.......................................................................................GVGLIGGSIARA-SRANGLAQEIVGVGRQTPNLQRAVELGVSYELDIATAVGGADLVVLCTPVGTF-EAIFKQLKPVWSEQCLYTDAGSTKQSVIDALKLVFKQVP------VNFVAAHPIAGSENSGVEITAEKQTAAWATKACEAWWQTMGAKVSMMDVQHHDEVFAATSHLPHILAYSLVELLKN-KQDEREIFEYA----AGGFKDFTRIASSDPMWSDICLANGSQLVKLMQDLAQLIEANDKQGLLDIFKSAQ. 277
114 7.000e-55UniRef50_A0A176WAH3 Uncharacterized protein n=2 Tax=Marchantia polymorpha TaxID=3197 RepID=A0A176WAH3_MARPO  ali  15  686.......................................................GAGQMGAGIAQVVAAAKYQAVLADVDNSALSRGMKSISSSLARF-------------VSKGSLSQEEATLGRIKTTVSLSE-LRDADLVIEAVSESDLKKRIFSELDRVVKPSAILANTSSISITRIASFTQRPQ-------QVVGMHFMNPP--PLMKLVELIRGLQTDEAVYNTVRELAQRLGKTV-TCSRDYPGFVVNRILMPMINEAFIALQEGVATAEDIDQPMGPLALADFIGLDTCLAIMRVLHHGLGDSKYRPSPLLVQYVDAGWLGRK............... 950
115 8.000e-55UniRef50_A0A1V4XJ15 Putative 3-hydroxybutyryl-CoA dehydrogenase n=7 Tax=Deltaproteobacteria TaxID=28221 RepID=A0A1V4XJ15_9DELT  ali  15  10.......................................................GAGTMGHGIAQAAVQAGFDAVLYDISAEFVEKGAARIKKSLAKRVEK-----------GKLAQDQMEAILGRLKTSTNLAEAVKNADFVVEAVPENDLKKKIFAELDKLCKPETILTNTSVLSVTAVAGATSRKD-------QVVGTHFFNPAAV--MKLVEIICPVGAADKTVEIAMDTMKRLGKTPIKV-KDTPGFIVNRLLGPLYMTAAQMVDIDTAMKLGAGHPMGPCELADFGGFDVIQMAQDSVFEYTHSEADKLNILYRKMIEAGRLGF-KNGKGFYDYMPDGTK 289
116 8.000e-55UniRef50_D0L0E5 Prephenate dehydrogenase n=7 Tax=Gammaproteobacteria TaxID=1236 RepID=D0L0E5_HALNC  ali  13  9.......................................................................................GLGLIGGSLS-LALKERGLVGEVVGYSRQLQTRLRARELGLRPVDSAAEAVRGADVVFIATPVQAMA-SVFAEIGPELDPGALITDGGSVKGNVVAAAKLSLSPAQWG-----QFVPGHPIAGTERSGHRVILTPENAPEMVTRAVDLWQSVGAIVEQMDVQHHDHVLAATSHLPHLAAFGLVSALSRLEERY-EVFRYA----AGGFRDFSRIASSDPMWRDICVANRDELLPMLDRLRQLIEASDSAGVEKLFADAK. 278
117 9.000e-55UniRef50_A0A0A0MSE2 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial n=40 Tax=Boreoeutheria TaxID=1437010 RepID=A0A0A0MSE2_HUMAN  ali  13  23.....................................KKIIVKHVTVIGG-------GLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKK-----KFAENLKAGDEFVEKTLST-IATSTDAASVVHSTDLVVEAIVENKVKNELFKRLDKFAAEHTIFANTSSLQITSIANATTRQD-------RFAGLHFFNP--VPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSC-KDTPGFIVNRLLVPYLMEAIRLEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWEMDAENPLHQPSPSLNKLVAENKFGKK............... 308
118 1.000e-54UniRef50_B9XMY9 Prephenate dehydrogenase n=4 Tax=Verrucomicrobia TaxID=74201 RepID=B9XMY9_PEDPL  ali  16  23.....................................................................................................RQRRLATKVDGYVRRSASIGECEKIGAHATRDLNRAVENADLVVLCTPLGQM-REMTEKMLPALKKGAIVTDVGSVKETVVEELEPLVAGA------GAFFVGSHPMAGGEKMGVIVTPTQNSDKDAVRRVEELWKSVGSRPVTISPVAHDDLVSRSSHLPHVVAAELANYVLSPAHPKEQ-----SLVCANGFRDTTRIASSPEMWRDISMANRKNLIEDLTEFQLALDNGDVKAIEEFFEKAKQ 279
119 1.000e-54UniRef50_A0A2M7A1N0 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Armatimonadetes bacterium CG07_land_8_20_14_0_80_59_28 Ta  ali  15  25..................................................................................................LRLKSHQLCKRVIGCARQETTLQTALGVGAEGFQRPEDAVQDADIVFIATPVADVLP-TFERILPHLPDRAIVTDVGSTKVEIVACAT----RIVGNDPARVEFIGGHPLAGSEKSGPVLTFTDRNTALALQTLGDLVESLGARTLRMTPEEHDEIVAFTSHLPHIAACALANAAGRTPGKRERIGKLI----ATGFRDATRLADSPELWRQICMTNREPILQALQEMRAFLKSEDAEALTQWLQSA.. 285
120 1.000e-54UniRef50_A0A1F8MB08 3-hydroxybutyryl-CoA dehydrogenase n=3 Tax=unclassified Chloroflexi (miscellaneous) TaxID=189774 RepID=A0A1F8MB08_9CHLR  ali  13  8.......................................................GSGTMGCGIAQVSAQAGYETTMVDVKREFIDRGMNMIKTSLGKFVQK-----EKIKQEDMNKT------LARLHTSVDMRSAAKDTDYVIEAVFEAEVKLPIFGQLEEVCPKETILANTSGIPVSLLASATKRPD-------KVIGTHFMNP--VPLMKGVEIVRTLLTSEETLQVSLHFVQSLGKETVVV-KDSPGFVTNRIITLVMNEAAKLLEENLASIEDIDKPMGPFELADMVGIDVLVDLLEGVYQQTGWERYKPAPLLKRMVEIGYTGR-KVGKGFYQLFGQG.. 285
121 1.000e-54UniRef50_A0A1F9V5X5 Uncharacterized protein n=3 Tax=unclassified Elusimicrobia TaxID=1797919 RepID=A0A1F9V5X5_9BACT  ali  13  10.......................................................................................GVGMMGGSIGLSIKKL-KLPYHVVGIGRNRTRLSKALKFGVQVTTDLVQGVKDAELVIICTPVEEIVPTI-KKIYSYLKPGAILTDVGSTKGNLLKEVETFYATLKNPPI----FIGGHPLAGSEKTGATVVLCPLETQKYLIELRNFWKGLGAKTIVLEPQIHDILVAQTSHLPHLLASGFVLFIERLSKQDSNAIQLL----AGSFRDLTRIADSDPLWAQICSQNENFILGSIKSYRDL-----LTRIINQIENSK. 270
122 1.000e-54UniRef50_A0A2R6F8G8 3-hydroxyacyl-CoA dehydrogenase (Fragment) n=1 Tax=Halobacteriales archaeon QH_8_67_36 TaxID=1919164 RepID=A0A2R6F8G8_9EURY  ali  14  13.......................................................GAGNMGHGIAEVAALAGYEVRMRDIKEEFVQDGYDNIEWSLNKLAEK-------------DQLTAEEADAALDRVTVDIEEAVGDADVVIEAVPEMEIKKDVYTDVEQHAPDEAVFTNTSSLSITELSAVTERPE-------QFCGMHFFNPPV--RMQLVEVITGAHTSDETLDTIEALADDFGKSPVRVRKDSPGFIVNRILVPLMNEAATIAEVDSTTKFDIGLPMGALELSDQVGNDVGLHVLEYMH-ETLGEAYDPCPLLEAKVEDEKLGKKTD-EGFYDY...... 286
123 1.000e-54UniRef50_G3VRA3 Hydroxyacyl-CoA dehydrogenase n=244 Tax=Opisthokonta TaxID=33154 RepID=G3VRA3_SARHA  ali  11  7.......................QFVRSMASSSSATGPAASAKKILIKHVTVI--GGGLMGAGVTQVAASTGHMVVLVDQSDEILAKSKKGIQENLQRVAKK-----KFAENPQAGDEFIKKTMS-NISLSTDAASVVHSTDLVIEAIVENKLKNELFQRLDKFAAEHTIFTNTSSLQITDLANSTTRQD-------RFGGLHFFNP--VPMMKLVEVVKTPMTSQKTFESLMDFSKALGKNPVSC-KDSPGFIVNRLLVPYLMEAIRMHERGDASKEDIDYPMGPFELLDYVGLDTTKFIMDGWHMDSKNPLFQPSQVLDKLVEEKKFGRK............... 308
124 1.000e-54UniRef50_S6GEE2 3-phosphoshikimate 1-carboxyvinyltransferase n=4 Tax=Bacteria TaxID=2 RepID=S6GEE2_9GAMM  ali  13  13.......................................................................GHTADDFFMVRNTLIIGLGMIGGSLAKAL-KENGFSRTVVGFDRSQQAVELGVQMGVRGCQDIKSAVTEADLIILAVPVKA-TAKVLAMLKPYLNAETIVSDVGSTKGSVIAAAVEVFGTVP------ANFIPAHPIAGSEKSGVKVIITPHASQQATQMIARMWQSTGAEILQMDVKKHDEVLAATSHLPHLLAFSLVDSLAQESESLD-IFRYA----AGGFRDFTRIAASDPMWSDVCGANKHAVLQQIE-----IFSKGLNRLKQAIEADDE 286
125 1.000e-54UniRef50_A0A1Y2K778 Putative prephenate dehydrogenase n=2 Tax=Proteobacteria TaxID=1224 RepID=A0A1Y2K778_9PROT  ali  11  1............................................................................MSFLIKRMTVIGVGLMGGSMA-LGLRERDLVGEIIGVDR-RSALDAALELGVHAHTQAEEGVKGSSLVVVATPVSAIAPTV-KSIAAHLEPDALVIDMGSVKGSIVKQCEA-------WMPDGVNFVGSHPIAGREHSGVRAAYGDLFDGAAVERAKQIWEAVGSSVEIMDAQYHDRVLAATSHLPHLMAYNVVNTLSDLEDDIAEVFRYA----ASGFRDFTRIASSDPMWRDICIENRDAILDILDRF-----KNDLEKLSKRVAEGD. 268
126 2.000e-54UniRef50_A0A2I0AAL1 Peroxisomal fatty acid beta-oxidation multifunctional protein n=1 Tax=Apostasia shenzhenica TaxID=1088818 RepID=A0A2I0AAL1_9ASPA  ali  14  292.......................SFLRAFYL--DVRQSAMAVTRETI-----GVIGGGQMGSGIAQLAAVAGFDVWLHDSDPGALRRASEGITAALRRLVSKGQ-LSQPAVSDVLNRLR-----------CTSNLEDLKHSDVIIEAIVESDVKKKLFSELDKLAKPNAILANTSSISITRLASATSRPS-------QVIGMHFMNPP--PVMKLVEIVRGADTSDEVFSKIKALAERFGK-IIICSQDFPGFIVNRILMPMINEAFYALYSGVATKEDIDHPMGPLELADFIGLDICLSIMKVLHQGLGDSKYNPCPLLIQYVDAGRLGRKR.............. 582
127 2.000e-54UniRef50_A0A2K6Q1J5 Hydroxyacyl-CoA dehydrogenase n=8 Tax=Amniota TaxID=32524 RepID=A0A2K6Q1J5_RHIRO  ali  12  29.............YPPRASSPSAQFMRSMSSSSTASAKKIIVKHVTVIGG-------GLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKKFAENPKAGG-----EFVEKTLSSIV-TSTDAASVVHSTDLVVEAIVENKVKNELFKRLDKFAAEHTIFANTSSLQITSIANATTRQD-------RFAGLHFFNP--VPLMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKVRHC-----ILQTCPRAVKSSLGDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIIDGWH-ETDVPLYQPSPCLNKLVAENKSGKK............... 333
128 2.000e-54UniRef50_Q16836-2 Isoform 2 of Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial n=20 Tax=Hominoidea TaxID=314295 RepID=Q16836-2  ali  13  38..........RGCLPRASSPGSPRCRRRCHTMAFVTRKKIIVKHVTVIGG-------GLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKK-----KFAENLKAGDEFVEKTLST-IATSTDAASVVHSTDLVVEAIVENKVKNELFKRLDKFAAEHTIFANTSSLQITSIANATTRQD-------RFAGLHFFNP--VPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSC-KDTPGFIVNRLLVPYLMEAIRLEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWEMDAENPLHQPSPSLNKLVAENKFGKK............... 381
129 2.000e-54UniRef50_A0A062VDF8 Prephenate dehydrogenase n=6 Tax=Methanosarcinales TaxID=94695 RepID=A0A062VDF8_9EURY  ali  12  4...................................................................................LIIGGTGETGRWFAKFYKKHGFDVIIWGINQKKEI----AQELGVKFADDLDREITTSDIVMISVPIN-ITEKTIEEIAPKMPQESLLMDITSIKTGPIEAMKK-------YAPADVEILGTHPMFGPSIPGQIVIFTPGRSSRWFPLIRGMYEDNGAHIEVMGAVQHDKMMAVVQGLTHFAYISIGSVFSELEFDVAQSRRFMSPMYDIMLDLVGRILAQNPLYAMIQM-NPEAYINRCNLMAEIVRDRDIEGFVDLMKKAS. 265
130 2.000e-54UniRef50_F8L8F1 Putative arogenate/prephenate dehydrogenase n=1 Tax=Simkania negevensis (strain ATCC VR-1471 / Z) TaxID=331113 RepID=F8L8F1_SIMNZ  ali  10  22.....................................................................................................................IFKRYAKKVLLSDMTSNEKIAKESDVLVFTVPIAS-TIEVIESLLPLIRKDQLLLDFTSIKEKPCEAMLKS----------SASVIGMHPMFGPSVQGQTVVLCPVRPDEWLDWIVDLLRKEKATVIQTTPEKHDRMMAVVQCLVHFTSLLFSKTMKEEGINPEELFQYASPVYRMQLYIAGRIANQSELYRDIQFQNPENMTESFETMKSTILKHDGDKFEETFKEIQD 250
131 2.000e-54UniRef50_A0A2R6EAC6 3-hydroxyacyl-CoA dehydrogenase (Fragment) n=3 Tax=Halobacteria TaxID=183963 RepID=A0A2R6EAC6_9EURY  ali  15  13.......................................................GAGNMGHGIAEVAALAGYDVTMRDIKDEFVRDGYEGIEWSLGKLAEK-------------GRISEDEADATLDRITVDFERAVADADVVIEAVPEMEIKKDVYAELEEYAPDRAIFTNTSSLSVTELSEVTERPE-------QFCGMHFFNPPV--RMQLVEVISGAHSSDETLETIEALADDIGKSPVRVRKDSPGFIVNRVLVPQMNEACWIVHEGDATVAEVDMPMGAFELGDQVGHDVTLHVLEYMH-EVLGDAYEPCPLLSEKVEAEELGRK............... 278
132 3.000e-54UniRef50_P34439 Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1 n=2 Tax=Caenorhabditis elegans TaxID=6239 RepID=HCDH1_CAEEL  ali  15  18.......................................................GSGQMGSGIAQVTASSGFNVMLADVNKKALDRAMKAISQSVTHLSKKQK-------GTDKEKSDFVTLTMSRIKTCNNVSTAVADADLIIEAAIENDLKRGIFAQIEQSCKKDSILTNTSS-------FLLEDVAKGLQDKTRFGGLHFFNP--VPVMKLLEVIRSDDTSDETYATLIKFGTAVGKTTVAC-KDSPGFIVNRLLIPYFFEAASMTDIDEAMKLGAGHPMGPFELADYIGLDTVKFVMDGWAAYPEVQLFEASPLVDKLVEGKLGRKTGD............. 291
133 3.000e-54UniRef50_A0A1W9RHS5 Uncharacterized protein n=1 Tax=Candidatus Omnitrophica bacterium 4484_49 TaxID=1970784 RepID=A0A1W9RHS5_9BACT  ali  10  1...............................................................................MFRKITIIGVGLIGGSLALAIKK-RKLADEVWGFFRRESSRKLAERKKIKGTRDLKRALSSSDFVILATPVSTII-SLAQEMRRMLPPGVLVTDVGSTKVKIVNALQKLFPK----------YVGSHPLAGSEKRGCNVTPTSRSDKNSVTAVRRFWKHLGCKVISMSPSSHDRILSQISHLPHIAVFGLLNAVN------DDCLKYAT----SGFLDTTRIGASDGLWLEIFKNNKYNLLRWLHRYRQLLQRNDFKNLLRYIQQASE 269
134 3.000e-54UniRef50_A0A1U9K9K3 Uncharacterized protein n=9 Tax=Bacillales TaxID=1385 RepID=A0A1U9K9K3_9BACL  ali  15  5.................................................................................EQVSIVGVGLIGGSLGLVFRQHG---IRVVGFDKDAESLKRAAALGVEGIPQLVKAVSDSDVIIVCTPVRTI-RAILEQLSAILKPGAIVTDTGSTK-------KELADFAKRLRWQNGSYIGAHPMAGSHRSGVEYVLTPETPLSTVEKLTKLLKFTRAKIVQMTADEHDRIMAAISHWPHVLAAMLVNQVGE----YNKRNGWYHTLAAGGFRDFTRIASSDPMWRDITLTNRVPILTMLEHMLLNEQEEDLEAFF........ 274
135 3.000e-54UniRef50_D7DUM7 Prephenate dehydrogenase n=1 Tax=Methanococcus voltae (strain ATCC BAA-1334 / A3) TaxID=456320 RepID=D7DUM7_METV3  ali  12  86...........................................................................................................................QELGVKYCSNNIEATKNADIVIIAVPISH-TLSVIEEVAPHMAKGSILMDMTSVKEKPALKMVE-------FTKEGVSVIPTHPMFGPSVPSQVVILTPVCDNKHFEKVKKFLENAEAKVIVIEPQKHDEIISVIQGLTHFIHISLGSTLRELGISIKDSRNFASPIYEMMINMVGRIVGQNALYADIQMNNDDTFIQECIKLRDTVKNRDKKAFIEDME.... 309
136 3.000e-54UniRef50_A0A2S5KR12 Bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase n=2 Tax=Proteobacteria TaxID=1224 RepID=A0A2S5  ali  14  7................................................................................SDRILIVGLGLIGGSLALALHKA-GFARELIGFDLKSENLALALDAVDRIETDLGRAVAEADIVVLSVPVKAM-EGVLERIAPYLRSNTLLTDVGSTKGNVVTASRRIFNPMLS------GWVPGHPIAGAENSGHKIILTPLSSAAAVDIISSMWRATGAEVLTMDVDHHDEVLAATSHLPHLLAFSLVDTLAQDHENRD-IFRYA----AGGFRDFTRIAASDPMWHDVFLANRDAVLEVLDRFTDG-----LSQLRTAVEQGD. 270
137 3.000e-54UniRef50_Q0AVM2 3-hydroxybutyryl-CoA dehydrogenase n=4385 Tax=root TaxID=1 RepID=HBD_SYNWW  ali  16  7.......................................................GAGTMGAGIVQTAAQAGFEVVVRDIKQEFVDRGIAGIDKLLSKNVDKGRMTAED-----------KAAVMGRISGTVDMG-AAADCDLVIEAAEVMDIKKAIFKELDSICKPECILANTSALSVTEIAAATGRAD-------KVIGMHFFNP--VPAMKLVEVIRGASTSQATYDAIKDLSVKMGKSPVEIN-EAPGFVVNRLLIPMLNEVANAADIDTSMKFGAGHPMGPLALADMIGLDICLKIMETLYKEFGDPKYRPCPLLAKMVRANKLGRK............... 271
138 3.000e-54UniRef50_A0A2D7BRR1 Cyclohexadienyl dehydrogenase n=3 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A2D7BRR1_9RICK  ali  16  14.......................................................................................GMGLINSSLVRDL-KVNNFYNNSVAYSRRNSTLKKIKQLVDTIESDPRKAVQDADLIIIGIPVAAY-ESIFNTIKDFIKPGAILTDVGSVKKEIIK-------RISKKIPKSINFIPGHPIAGTEKSGPECILTPKANSSSIKLVKNMWKSVGMKVDIMDPNHHDLVLAITSHIPHIVAYSIVGTVANLEASVKEVIKYA----ASGFRDFTRIAASDPMWRDIVLLNKKSILKMLEYF-----KKDLGKLEQAIKNNND 272
139 4.000e-54UniRef50_A0A259UBK1 Prephenate dehydrogenase n=1 Tax=Sporomusa acidovorans DSM 3132 TaxID=1123286 RepID=A0A259UBK1_9FIRM  ali  13  7..................................................................................QIAIIGMGLIGGSLGLAIKAAQGSNIEIVGIDTNKLALTIAKQCGAAITTDYKTGVENADIVFLCTPVLQIAAHI-SEIAFHVKKGAILTDTGSTKTYLMEKIAAVL-------PREVHYIPGHPMAGREKSGIEAAECTLFRDKWYETLCQVISWTGARITQMNAAQHDRCTALISHMPHIGAAALV-TLLQYSEDQETSIKLAG----GGFRDTTRIASSNAMWADICMTNTEPIADSLDKFSQIIRQKDRNSIHAFFANAK. 280
140 4.000e-54UniRef50_A0A2M7GY66 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=5 Tax=Bacteria TaxID=2 RepID=A0A2M7GY66_9BACT  ali  14  1...............................................................................MFKKVCIVGPGLIGGSLALALKKA-GMAETIAGIGHRSISLERALKLGAKGFLEFRKGISRADLVVLATPVATI-LKYLEKNFSSLEKGALITDTGSTKSEIVKKAE-------FLLPSSVYFVGGHPIAGSEKKGVELTKTKKTNRKALQMVKELWQSVGAKTKVLSPAGHDRIIAYLSHLPHLAAVALVKAIKESSERKNFSF------AGSGFKDTTRIASSPQLWCDIFSTNSNEVLSALDDF-----KKSLNTIEKLIEKKD. 263
141 4.000e-54UniRef50_A6RDL7 3-hydroxybutyryl-CoA dehydrogenase n=28 Tax=Dikarya TaxID=451864 RepID=A6RDL7_AJECN  ali  17  21........................................SFSTSPIAAAAEVKKVAGQMGLGIALVTAQAGVPVTLIDNSQASIDKGMQFAEKLLEK-------------DVSKERITRDHATQIRIKPSTNLSD-LEDVDFVIEAVPIPALKSSIFAQLAEIAPSHAILTNTSSISITKIAAATTKNPTDLSASSRVISTHFMNP--VPVQKGVEIITGLQTSQETIDTAMEFVKRMGKIPARST-DSPGFLANRILMPYVNEAIMCLENGIGTKEDIDSPMGPLTLADFIGLDTCLAIMNVLHTETGDSKYRPAGLLKKMVDAGWMGKK............... 313
142 5.000e-54UniRef50_A0A2J5HV15 3-hydroxyacyl-CoA dehydrogenase n=3 Tax=Aspergillus TaxID=5052 RepID=A0A2J5HV15_9EURO  ali  17  20........................................AFSTSPVARAAEVKSLAGQMGLGIALVAAQAQVPVTLVDNSQGSIDKGLKFADKLLEK-------------DVAKERLTREAADIVRSRITPTLKDDLSSVDFVIEAVPIPDLKTSIFSKLAQIAPKHAILTNTSSISITKIAAATTTDPKDLQAASRVISTHFMNP--VPIQKGVEIISGLQTSQETIDTALKFMERMGK-VSSVSADSPGFLANRILMPYINEAIICLETGVGGREDIDNPMGPLTLADFIGLDTCLAIMNVLHQETGDSKYRPSGLLKRMVEAGWKGRK............... 311
143 5.000e-54UniRef50_A0A1G3XW01 Uncharacterized protein n=10 Tax=Bacteria TaxID=2 RepID=A0A1G3XW01_9BACT  ali  11  19.......................................................................................GVGLIGASFALALRKY-KLCKQITGYGRSPENLQKAKEIIDSFELDPAKACDSSDLVLFAAPVGSFI-DIAKRIRSSLNKGAIVTDVGSVKGKLVSDLEALM-------PGGVCFVGGHPIAGSDRSGIIITPTDKTDKNALEKVIALWKALGSIVKQINPDEHDRIYASVSHLPHLIAYLIVNTVA----DIDSSLKFSGQ----GFVDTTRIASSPELWRDICILNKENLLESIE-----IFKNNLDRASQHLRACD. 272
144 5.000e-54UniRef50_I3KLS8 Hydroxyacyl-CoA dehydrogenase n=20 Tax=Euteleostomi TaxID=117571 RepID=I3KLS8_ORENI  ali  11  29.......................................................GGGQMGAGIAQVAASTGHSVTLVDTSGDILKKSIKMIEGSLKRVTKKKFSDKPEA-----GEEFIKKVVQ-KVSTSTDAESAVQGSDLVVEAIVENKIKQDLFSRLDKLAPPHTIFANTSSLSICDIASSTNRQD-------RFGGLHFFNPVA--MMKLVEVIGTPATSQDTLDSLLDFSKVLGKTPVSC-KDTSGFIVNRLLVPCMMEAVRLYERGDASKEDIDYPMGPFELADYVGLDIVKAVIENNPLFDSSDLLNK............................... 290
145 5.000e-54UniRef50_A0A2A5X152 Prephenate dehydrogenase n=3 Tax=Proteobacteria TaxID=1224 RepID=A0A2A5X152_9GAMM  ali  11  13.......................................................................................GVGLIGGSVAKAL-RCQNAVGHVTGFGRRESTLQRAQALGVSWSLDLGAAVEQAEVVIISSPVNTIA-SIFHELKSYLGETTIVTDAGSVKGSIVDAA------VRGLGDKIINFVPGHPIAGKEKSGVRTILTPNTRTEAISAVKDMWETIGAEVVFMEPSVHDDLLALTSHLPHALAFILVDLLSRQN-NTKNCLNLS----AGGFYDITRIASSDPMWRDIFLSNKHAILQRLDDLVGLIDRSDSSALEEMFKHANE 282
146 6.000e-54UniRef50_Q12UK0 Prephenate dehydrogenase n=3 Tax=Methanosarcinales TaxID=94695 RepID=Q12UK0_METBU  ali  12  4...................................................................................LIIGGTGEMGKWFTKFFTDHGYEVVVWGSSQKTEI----AKQMGVEFASDLDNAIRTSDIVIITVPI-DITADVIRETAPKMKAGSLLMDLTSIKAEPVRAMRE-------TAPDGVEILGTHPMFGPSIPGQIVIPTKGRSEKWFPIMRNLFEENGAHIEIIKPEEHDKFVSVVQGLTHFAYITIGNTFKSLDFDVSMSRRFMSPVYEIMVDFVGRILGQNPLYAHIQMQNEETFISECNILSEIVREQDIEAFCNKMTEA.. 265
147 6.000e-54UniRef50_N8Y867 3-phosphoshikimate 1-carboxyvinyltransferase n=1631 Tax=root TaxID=1 RepID=N8Y867_ACIGI  ali  14  13.......................................................................................GLGLIGSSLARVIAAEH-LAENVVASTRSKKTLEDAKALGIAGFSDPVEAVKDADLIVLALPVRA-TQKVLETIQAYVSENAIITDVGSTKGNVVAAAHAVYGENLP-----VGFVPGHPIAGAEHTGVKVILTPLTSADWVEKLIQLWQAAKAEVICMDVDKHDEVLAHTSHLPHLMAFNLVEQLANREDNLD-IFRYA----AGGFRDFSRIAASDPMWHDIFFANKTAILKAVD-----GFETQLATLRQLIED... 268
148 7.000e-54UniRef50_A0A1F6TSN6 Uncharacterized protein (Fragment) n=1 Tax=Candidatus Muproteobacteria bacterium RBG_16_65_34 TaxID=1817760 RepID=A0A1F6TSN6_9PRO  ali  13  270.......................................................................................GVGLIGGSLARALREARAV-REIVGYGRSLGNLQQAVDLGVRAAVSAPDAVRGADMIVLAVPVGAM-PEILGEIAAAIDDGAVITDVGSVKGGVIEVARRALGA------RFARFVPGHPIAGTEQSGVRVILTPETDPGALASVRAMWSVAGAEVVAMSAGEHDRILAVGSHLPHLLAFALMDLVVR-RDDHRAVFQCVGN----GFRDLTRIAASDPMWRDICFANREAVLEVLRELELAIARGDGEWLIETFTRAK. 538
149 7.000e-54UniRef50_A0A1Y5DYY1 Prephenate dehydrogenase n=2 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A1Y5DYY1_9GAMM  ali  13  4..................................................................................QLAIIGVGLIGGSLS-LALKQAGKVNEVIGYSRTESVRQQALDLGVRAANSIADAVKEADVIFLAVPMAAMEP-VLVELAAHVKPGAIITDGGSAKAQVVQAARSAL------TNNFEQFVAGHPIAGTEKSGHRVVLTPVTNPAALESIRQMWQATGAEVLNMEVEHHDVVLAATSHLPHVLAFNLVGML-AERDDCDEVLRYA----AGGFKDFSRIASSDAMWRDICLTNKDAILGLLEQIEQAIREQDGGYLTDVFERAKQ 278
150 8.000e-54UniRef50_A0A256KE24 3-hydroxyacyl-CoA dehydrogenase (Fragment) n=6 Tax=Halobacteria TaxID=183963 RepID=A0A256KE24_9EURY  ali  13  13.......................................................GAGNMGHGIAEVAALAGYDVSLRDINDELVQNGYDQIEWSLGKLAEKDRIGDDE-----------ADAALDRVDAFVDLEDALDGADVVVEVVPEMAIKKDVYDEVVEYAPDEAVVTNTSSLSITELSEVTDRPE-------RFCGMHFFNPPV--RMDLVEVISGKHTSEDTLELIEGLAESMGKTPVRVRKDSPGFIVNRILVPLMNEAAWIVESGDATKFDMGLPMGSFELADQVGVDVGYHVLEYMH-EVLGDAYRPCPLLGEKVEAENLGKK............... 278
151 8.000e-54UniRef50_A0A0A0BFD1 Cyclohexadienyl dehydrogenase n=76 Tax=Proteobacteria TaxID=1224 RepID=A0A0A0BFD1_9GAMM  ali  13  4..................................................................................RLAIIGVGLIGGSLA-LALKGKGAVNEVVGYSRSEDARQQALDLGITAADSLAEAVSGADLVFVAVPMGAMN-SVFEGIADYLSPEAIITDGGS------AKAQVVAAAKQCLGEKFKKFVPGHPIAGTEKSGHRIVLTPVTDSAATAKVKAMWQLTGADVFEMNVEHHDTVLAATSHLPHVLAFNLVGML-AERNDCDEVLRYA----AGGFRDFSRIASSDAMWRDICLGNQDAILSLLEQIEEAIRNQDGEYLIDVFSRAKK 278
152 9.000e-54UniRef50_A0A161QAN8 Prephenate dehydrogenase n=1 Tax=Thermovenabulum gondwanense TaxID=520767 RepID=A0A161QAN8_9FIRM  ali  18  3....................................................VKEIAGLIGGSIAKAFKLLGYDVIGVDRADETLQQAL------------KDNVISKDSFNINTGDEK--------------LFEALRRADAVFVCTPVFRIV-STIEKIQPFLKEGCIITDTGSTKRQIVKSAQKV-------VKEKIYFIGGHPMAGSHFKGCAWILTPNTPDKILEELISLIKALGATVYILSPLEHDKVVAAVSHLPQVVATCLGNTLSEVNEN-GKILKFAGR----GLKDTTRIASSPEIWVDILLSNRDELIN-----LISIFIDKLEHIRNYLEKEDD 271
153 9.000e-54UniRef50_C1BI43 Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial n=50 Tax=cellular organisms TaxID=131567 RepID=C1BI43_ONCMY  ali  13  14............................................SSAVRNAAIKHVGGQMGAGIAQVAATTGHSVVLVDTNEEILKKSAKGIEGSLKRVVKK-----KFADKPDAGAEFIAKVM-ANVSISTDAASVVGSTDLVLEAIVENKIKQGLFGALDKVAPAHTIFANTSSLPITDIASSTSRLD-------RFGGLHFFNP--VPMMKLVEVIGTSATSQDTFDSLLAFSKALGKTPVSC-KDTPGFIVNRLLVPYMMEAIRLEDIDIAMKLGAGYPMGPFELLDYVGLDTAKFIMDGWEKDPDNPLMQPSEMLNKLVAEGKFGKK............... 300
154 9.000e-54UniRef50_A0A109CHS5 Prephenate dehydrogenase n=2 Tax=Nitrospirae bacterium HCH-1 TaxID=1748249 RepID=A0A109CHS5_9BACT  ali  15  19.................................................................................................ALAMKKHGLAKKICGFGRNETNLKNARARGIDYALNLGDLAEGADLVIFAAPVRAFKP-IAGEIAPYLKTGAIVSDVGSVKGALVYEMESAM-------PEGVAFVGAHPIAGNDKSGIVITPTSRTDKTACQTITSMWERFGCKVEELTPERHDEILSSISHLPHIAAYALVNAVHEINPNF---IGYSGT----GFMDTTRIASSPEIWRDICVLNRENILNHL........................ 245
155 9.000e-54UniRef50_A0A136JXR9 Prephenate dehydrogenase n=11 Tax=Nitrospirae TaxID=40117 RepID=A0A136JXR9_9BACT  ali  15  6................................................................................FKQVAIVGVGLIGGSLGMILRR-QKIADSIVGIGRRVENLKTAVELGARYVSDPREGVEGADFVLLATPVDTYERH-LREWAGCLTPGAIVSDVGSVKGELV-------TRSEALMPQGVRFVGAHPIAGKEKTGVRCILTPTTDAEALQTVRAIWELAGSIVLEMDPFLHDRILGAVSHLPHVAAFALMTALADVR-DHGVPELDLAGHSGGGLRDTTRIASSPEMWRDIFLWNRDNLVRHLDELKRLIIAGDAAGIEKQLDQAK. 284
156 1.000e-53UniRef50_V5C919 Protein TyrC n=51 Tax=Proteobacteria TaxID=1224 RepID=V5C919_9GAMM  ali  11  9.......................................................................................GVGLMGGSIARAA-RQYGLSQTIVGFGRDDDNLQTAQNLGVEHYTDIARALANADCIVLATPVGAI-ESVFASLKPFWDEKAIYTDVGSTKGSVISAAERIFGSVPD------NLVPAHPIAGAEQSGVVITPTNATRPDGVQIMRMFWERLGAQVAIMDAAHHDAILAATSHLPHIVAFALVDMLGH-KDEQSEIFKYA----AGGFRDFTRIASSDPMWRDICVANKNEIIPLIQQLK--IELGKIESLLD....... 264
157 1.000e-53UniRef50_A0A2D5VVQ2 Uncharacterized protein n=3 Tax=Pedosphaera sp. TaxID=2024890 RepID=A0A2D5VVQ2_9BACT  ali  13  25.......................................................................................................GGLAKRVLGLVRREESIQQAQEAGIQAYLEPQEAVQEADLIILCTPVLQI-PALMEKMLPHLRPGTLVTDVGSVKRELVDHLEPLLTSA------GCXYIGSHPMAGSERHGLEITPTATSPDASVQTIMQFWESVGGXPLIMEAAQHDQWVAHASHLPHAVAAMLAWRTLDPAQGALQAELCST-----GFRDTTRVASSPEMWADILISNRSAIGQSLQS-----HQEQCTELKQWLENNDR 267
158 1.000e-53UniRef50_A0A0E9N984 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial n=3 Tax=Saitoella complicata NRRL Y-17804 TaxID=698492 Re  ali  15  457.......................................................GAGQMGLGIALVAARAKIPVSLVDSNQASIDKSMKFMEKLLQK-------------DVSRQKLSNSEADEIRIKTSTDMSSALSSADFVIEAVPILALKQSIFSQLAEICPPHAILTNTSSIGITKIAAA------ATGAESRVIGFHFMNP--VPVSKAVEVIRGIQTSDETLQKTLELAKAMGKKPC-TSVDSPGFLANRMLIPYINEAIICLEQGLGTKEDIDMPMGPLALADFIGLDTCLAIANVIHKDTGDTKYRPSILLAKMVDAGWHG-VKSGKGFYEY-ENGRK 737
159 1.000e-53UniRef50_A0A1G3BD67 Uncharacterized protein n=3 Tax=unclassified Planctomycetes TaxID=473814 RepID=A0A1G3BD67_9BACT  ali  13  27.....................................................................................................KERKLARRVIGVGHRDASLEKALEAVDHATKDLKEGVREADIVVLCTSV-KLIPELAEKILPWMKAGSVLTDVGSTKEHIVEQIRAVI-RGTRSPVKGVGFIGGHPLAGSEQRGIVCILTPGRDSRSRGIVKSMWEALGAKVKFLSPEGHDLIIAFISHLPQLVAASLVNTL-----------RPGQPAFARGFRDVTRIASSDPLWRDILLQNRESLLEAITDF-----QKEIALIKRVLQERD. 269
160 1.000e-53UniRef50_I1YFE7 Cyclohexadienyl dehydrogenase n=14 Tax=root TaxID=1 RepID=I1YFE7_METFJ  ali  13  9.......................................................................................GVGLIGGSLALALKKNGQVAQ-VIGYARSEAVRHEALQLGIEAAASIADAVQQADMVFVAVPMGAMA-AVLAELAPYVNEKTIITDGGSAKQQVIEAAKASLGSLFP------NFVPGHPIAGTEKSGHRVVLTPTTRHDALEQVQQMWQQVGADVFVMDAEQHDVVLAATSHLPHVLAFNLVGML-AQRDDCEAVLRYA----AGGFRDFSRIASSDAMWRDICLGNREAVLDLLQQYRAGIRTGDGDYLSTFFNQAKQ 278
161 1.000e-53UniRef50_A0A1Z8U2C9 Uncharacterized protein n=1 Tax=Proteobacteria bacterium TMED51 TaxID=1986847 RepID=A0A1Z8U2C9_9PROT  ali  18  28.....................................................................................................KTSGAVETIVGFGRNPENLETALDRGDSVTTDLAEAVSAADLVLLATPVGTL-VELFPQVGAYLKPGAILTDAGSVKGHVVDNARVILGSHFP------QFVAAHPIAGRERSGVVLTPSAETNPRAIETVQQMWERVGAKVRLMDTVTHDHILGMTSHLPHAVAYALVAQLG----GLEGIEDYSS-MTAGGFLDITRVASSDPMWRDIFVHNAEAVLKRLEELVRNKSADELEAWFESAKKLR. 286
162 1.000e-53UniRef50_A0A1H0AE32 3-hydroxyacyl-CoA dehydrogenase n=2 Tax=Bacillus TaxID=55087 RepID=A0A1H0AE32_9BACI  ali  12  8.......................................................GAGIMGHGIAQIAALAGYNVVLRDINDDMLEKGLQSIDRSLNLMIRSEKITV-----------TQKDKCLQRIQLKKDLNDSVKEADLVIEAIPVLSLKQELFQQLDEICSPETILTNTSQLSVTLIGAKVSRKD-------KIIGTHFFNP--VPVMKLVEIINGFETSDETLQTVQNFCHTIGKETVVCRKDTPGFVTTRLLLAQRAEAFRLYEEGVASIEDIDHPMGPFQLADLAGLDTGLKALTSMEENYG-ERFKSPTYLKQMVALGYLGK-KSGKGFYEY...... 281
163 2.000e-53UniRef50_A0A1H6M2L9 Bifunctional cyclohexadienyl dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase n=2 Tax=Bacteria TaxID=2 RepID=A0A1H6M2L9  ali  12  8.......................................................................................GVGLIGGSFALGLKKHKFQQVNIVGFGRNEANLQQAQALGVTYSLDIAQALSGVELVLIATPVNSFK-NILELIKPHINDNVIVCDVGSTKGSVIATAKEVFGTMPAK------FIPAHPIAGKEQNGVRVILTPTADTQAIERVSECWQALGARVEIMNDKTHDDLLAMTSHLPHMLAFSLMDYVIESGSN---ALDYA----AGGFKDFSRIASSNAMWRDICINNPDEIVK-----HIAGFQQSLDKLSSLIEEGK. 265
164 2.000e-53UniRef50_A0A194QAI6 Putative 3-hydroxyacyl-CoA dehydrogenase B0272.3 n=14 Tax=Ditrysia TaxID=37567 RepID=A0A194QAI6_PAPXU  ali  13  19...............................................AIKTVTVVGGGLMGSGIAQVAAQAGQNVTIVDIKPELLDKAQKSIHNNLTRVGKKMYK------DDSAKIENFVKESYNRIQVSTKIEDAVK-ADLIIEAIVEKDVKQELFNKLDQLAPEHTILTNTSSISINEIGAGIKRKDRYG-------GLHFFNP--VPVMRLLEVIKGDHISEATYQTMMEWGKSVGKTCITC-KDTPGFVVNRLLGPYSAEAIRLYERGDASKEDIDYPMGPFELADYTGLDTNKFVLQVMYEKTNNPVFKPIPLLDKMVEGKLGIKSGE............. 299
165 2.000e-53UniRef50_W4LFR5 3-hydroxybutyryl-CoA dehydrogenase n=79 Tax=cellular organisms TaxID=131567 RepID=W4LFR5_9BACT  ali  12  9.......................................................GSGLMGLGIAQVAAQSGLQVRLNDANADALQDAITRIRKGLERLRDRDRLDGDVDTILTR------------IHLTTDLQE-FAQSEVVIEAISENDLKRGLFAQLDDICAPHTILANTSSISITNIAAATSRPEYV-------VGMHFFNP--VPAMQLVEVTRGIATSDTTVDKITQLGEQLGKTVVQA-ADTPGFIVNRILVPMLVEAIYAYQEGAASREDIDHPMGPLTLADLIGLDTLLAICDVYYRGFGDPKYRAPILLRRYVTAGWLGRK............... 272
166 2.000e-53UniRef50_A0A1G0YBU3 Uncharacterized protein n=1 Tax=Lentisphaerae bacterium GWF2_57_35 TaxID=1798576 RepID=A0A1G0YBU3_9BACT  ali  15  21.....................................................................................................KAQGFSGTIAGYARRLETCEEAQKMVDRVSNDPSEAVEGADLVVLCVPILSM-PDLVRGFRDRLKSSCLLTDVGSTKAEVDEAIRQELGS------RAVFFIGSHPIAGSEQQGLACILTPRSPAEKVEALASFWKSLGAVVYRMPAVEHDRIMARTSHLPHVIAASLAAVVGRDG-DWEQLGRFCGP----GFRDTTRIAGSSEVWRDIIKTNKDAYKNKLESWSELIKKDDFQGLQSFLEQSR. 276
167 2.000e-53UniRef50_P45856 Probable 3-hydroxybutyryl-CoA dehydrogenase n=158 Tax=cellular organisms TaxID=131567 RepID=HBD_BACSU  ali  15  1..............................................MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLKRLKKQLARDAEK-----------GKRTETEVKSVINRISISQTLEEA-EHADIVIEAIAEMAAKTEMFKTLDRICPPHTILANTSSLPITEIAAVTNRPQ-------RVIGMHFMNP--VPVMKLVEVIRGLATSEETALDVMALAEKMGKTAVEVN-DFPGFVSNRVLLPMINEAIYCVAIDEVMKLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKK............... 274
168 2.000e-53UniRef50_L7ZYI0 3-hydroxybutyryl-CoA dehydrogenase n=94 Tax=Terrabacteria group TaxID=1783272 RepID=L7ZYI0_9BACI  ali  15  9.......................................................GAGVMGSGIAQTAAMAGKTVYLYDVSEAALQNGLASAEKSLRRFVKTGGLSEPE-----------ARAALGRIRSTVDLAEAVRGADVVIEAVPENALKKDVFQQLDQLAKPDAILTNTSELSVTALAAATNRPENV-------IGMHWFNPA--PVMKLIEIVKGETTSDDTVDAIRRLSVELGKETVVV-KDRQGFVTTRALAAHMIECIRMYEEGVASAEDIDKPMGPFELADMVGLDTLLFVSENMEAYGDRFRA-PQLLRKLVEAGHLGRKTG.............. 275
169 2.000e-53UniRef50_A0A1U7EYD4 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase n=118 Tax=Halobacteria TaxID=183963 RepID=A0A1U7EYD4_NATPD  ali  17  13.......................................................GAGNMGHGIAEVAALSGYTVNLRDIKEEFVQDGYEQIEWSLEKLAEK-------------DQITDEKAEDALDNVTVDVEEAVGDADFVIEAVPEMDIKQDVYSDVEEHLPEHAIVTNTSSLSITDLSEVTERPE-------QFAGMHFFNPPV--RMQLVEVISGEHTDEETLAVTEALAEDFDKTPVRVRKDSPGFIVNRILVPLMNEACWMVSEDAATKFDMGLPMGSFELGDQVGHDVTYHVLEYMN-DVLGEAYEPAPFLEELIEEERYGKK............... 278
170 2.000e-53UniRef50_A0A1Q9NP77 Putative 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=cellular organisms TaxID=131567 RepID=A0A1Q9NP77_9ARCH  ali  13  13.......................................................GSGLMGNGIAQTCATAGYSVFMIDIDQKFVDNGLASIEKSLGRIVKKGKLSQEDSDSIRK-----------RIQGTTDLKKGISEADVVIEAVTEKDIKNQLWKEIGELSKPDTIFA------SNTSSISITSMATASKRPEKFIGMHFFNP--VPLMKLIEIIRGQLTSDETHKTISELSKKLGKEVITVN-EAPGFAVNRVLIPFMLEAIRAVEQGVCTPEDMDHPMGPFTLLDYVGLDTTLFIADYMFEESGNPMFKAPNLLRKMVRAGLHGKK............... 280
171 2.000e-53UniRef50_A0A257MX75 3-phosphoshikimate 1-carboxyvinyltransferase n=1 Tax=Methylococcaceae bacterium NSM2-1 TaxID=1917482 RepID=A0A257MX75_9GAMM  ali  11  9.......................................................................................GVGLIGGSIARAA-RQYGLSKSIVGYGRQEDNLETAKRLGVDFYLQIEEAVQGADCVVIATPVASI-ESIFALLKPFWSDHTIYTDVGSTKGSVVSAAQRVFGTVPD------NLVPAHPIAGAEQSGVELIITPLTRTEALQNIKCFWELCGSVVSVMDVKRHDAVLAATSHLPHILAFALVDMLGH-KDEQSEIFKYA----AGGFRDFTRIASSDPMWRDICSANKNEIIPLIQQTR-----EQLDKIQRLLENDD. 267
172 2.000e-53UniRef50_A0A2M7SCS6 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Candidatus Desantisbacteria bacterium CG_4_10_14_0_8_um_f  ali  15  11.......................................................................................GVGLIGGSLGMALRK-KKAASGVTGVGRNRARLRKAVRLGASCTTDLRAGVRDADIIVIAAPVG-VIQGIVSRILPFLKKGCVITDTGSTKKALVA------DKIKPRFPNGIGFVGGHPLAGSQLGGVVLTPVPGTDRKALAAVKRMWESAGASVELLSPAKHDEVLGLTSHLPHLVAVALV----RSALGAEGAQRFI----AGGFRDTTRVASSSGMWRDIFVSNRAGVLKALKKFRSLIKSGNGASLARILDSAKR 277
173 2.000e-53UniRef50_UPI000B7D20CE prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Dehalobacterium formicoaceticum TaxID=51515 RepID=UPI0  ali  13  28......................................................................................................KKGQIPALVGYDLNLTSVQQAVAMRAVGTMSLKLAVEDADLVILAVPVGQIKNTVLS-ILPFLKDGCVFFDVGSTKESIIKEMSRIL-------PAHIAFIGGHPMAGSEKAGIIYVITPKASPENLHKVLQVIEWLGAKPKIMSPEVHDQAVAGVSHLPYLAAVSLVQTVGELGHKIPD----APLLAAGGFRDTTRIAGGDAMWRDIVLSNQENLIEMIDAF-----QKQLDQVKEYLIKGD. 270
174 2.000e-53UniRef50_A0A0W0WKH1 T-protein n=1 Tax=Legionella nautarum TaxID=45070 RepID=A0A0W0WKH1_9GAMM  ali  15  32..........................RLTEVKKQQGLPLYCLSREASMLAARQKE------------ATEQGVQFINDILRRIIRESYAQENNLGFTCTNPQANKIIIVGGYGKMGSIFSELFSLSNYEV-LNLGEMFEDASLVLLAVPIDK-TSLIISELPP-LPSTCILADITSIKSKPIAEMLKVHSGA---------VVGLHPMFGPHIKNQVIIHCNGRNPHDYEWLLEQLRIWGAQLQPSTPEQHDKMMRFIQVLKHFTSFTYGVYLHSEEADIGELLNFSSPTYRFELAMVGRLLQSPELYAEIILSSPEAMLRRYHEMLQEIEQKGSSSFINYFEETK. 347
175 3.000e-53UniRef50_A0A2A4RHS2 Prephenate dehydrogenase n=1 Tax=Gammaproteobacteria bacterium TaxID=1913989 RepID=A0A2A4RHS2_9GAMM  ali  17  22..................................................................................................LALKEADACKHITGAGRSETTLQKAKQLNIAYETDISKAVEDADLIFVSVPLGA-TESVFKQISGLTRAGAIITDAGSAKQQVQVLAEKVFSKGHVVRR----FVAGHPIAGTEMSGPRVILTPTTNESAITLVSALWQKSGAIVETMDAEHHDKILAATSHLPHMLAFCLVHCLKNM-DDIEDVFRFA----AGGFRDVTRVASSDPMWRDICLNNXQPILXMMKRYKDALEAGDGEKLLEVFRQAK. 286
176 3.000e-53UniRef50_K8BI84 Chorismate mutase I / Cyclohexadienyl dehydrogenase n=2 Tax=Cronobacter dublinensis TaxID=413497 RepID=K8BI84_9ENTR  ali  12  211.........................................................................DLIEDVLRRVMRESYSSENDKGFKTLNPALRPVVIVGGGGQMGQLFEKMLTLSGYQVRIDWPQAAADAGMVIVSVPV-HLTEAVIRKLPP-LPEDCVLVDLTSVKNVPLQAMLGVHQGP---------VLGLHPMFGPDLAKQVVVYCDGRKPEAYQWFLEQIQVWGARLHRISAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPLYADIIMSNLSLIKRYYQRFGEAIEQGDKRAFIDSFRKVE. 489
177 3.000e-53UniRef50_UPI00089A9497 bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase n=1 Tax=Marinobacterium georgiense TaxID=48  ali  14  26..............................................................................................SFAKAL-KIRSCVREIVGADRSEEECRLGLELGVRVATDLEAEVSAVDLIVLAVPVKAM-ESVLEQIRPWLRLRTLVTDVGSTKGSLVAAARRLFGQLPPT------FIPGHPIAGAEKSGVKVILTPLTDPNATLELARLWQAVGAEVLQMEVERHDEVLAATSHLPHLLAFSLVDTLAREEENLD-IFRYA----AGGFRDFTRIAASDPMWHDICVANRSAVLAQIDRLRSAIDTGDSQTMLGIFTRAK. 287
178 3.000e-53UniRef50_A0A2H6F3A6 Cyclohexadienyl dehydrogenase n=2 Tax=unclassified Bacteria (miscellaneous) TaxID=49928 RepID=A0A2H6F3A6_9BACT  ali  15  15.......................................................................................GVGLMGSSFALALRK-NGYKGKITGIGRREKNLIKAKDLGIDYSTVHAEGVKNADLILLASSVGQF-EQIAKNIRNNIKNGAIVTDVGSVKAGIIRKLE-------PLMHEGVSFVGCHPIAGKECSGCIITPTSNTNKEALDRVIDIWGRIGSKIILMSPEEHDLVFAAVSHLPHVVAYALVNSILNVDKDILH-------YGGRGLKDMTRIALSPELWRDICTNNRNDILKTLKRFSSSI-----SKMIKLFENSD. 268
179 3.000e-53UniRef50_D3E136 Prephenate dehydrogenase TyrA1 n=24 Tax=Methanobrevibacter TaxID=2172 RepID=D3E136_METRM  ali  13  4.......................................................................................GIIGGTRGLGRLAWYLKDFDFDVTVTGRDSIVGAQVEEIGVKYSNNNKKIVQDSDIVIISVPISS-TESVIEELAPFMKDGSVMLDVTSVKEGPSKKMKECLS-------EGVEFIPTHPVFGPDLKGQIIVLTPIKKGKWYPRIYKFLEDKGMRIIETTAEHHDDMMGIVQVLTHFSYISTASAIERLQVDLKDTQNYESPIYNLMIDTIARIVSQNPLTYSIQHENRQALFDSMSELKDALSKEDEEEFVEIALKATK 267
180 3.000e-53UniRef50_A0A2T4DAY1 Bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase (Fragment) n=2 Tax=Gammaproteobacteria TaxID=1  ali  13  17..................................................................................................................................AASIADAVRGADMVVLAVPVRA-TRKVLEQVRPALEPDAVLTDVGSTKSSFVTDVEAVFGGLSPY------VIPGHPIAGSEKSGIKVILTPDVSQPHLARLKALWEGCGATVLTMSVAYHDEVLAATSHLPHLIAFSLVDTLAGEDENMD-IFRYA----AGGFRDFTRIAASDPMWHDIFLSNRDAVLRVIDHF-----THDLEQLRTAIANQD. 229
181 3.000e-53UniRef50_A0A2E8EGA4 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=Candidatus Bathyarchaeota archaeon TaxID=2026714 RepID=A0A2E8EGA4_9ARCH  ali  13  1................................................MKKSTVIGAGIMGHGIAELLALAGVEVTIVDINEELLKKAVENITWSLGKFVERRRI-----------REEDAKAALERIKTNTNLEEAVVNADLVVEAVPVMELKKIIYKKLDEAAPGHAILANTSSLSITEMAEQTGRPE-------KVVGMHFFNPPML--MALVEVVRGEETDDETTDAIVKLVEKLGKTPVVVRKDVRGFIVNRVIGAVMNEAFWVVENGEATIEEVDAPLGAFELADMIGLDVMGQIMETA--YGDVAKSSP-MLAKLVEEGNLGQKTG.............. 275
182 3.000e-53UniRef50_A0A1F7SJZ3 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Candidatus Schekmanbacteria bacterium RIFCSPLOWO2_12_FULL_38_15 TaxID=1817883 RepID=A0  ali  16  1...........................................................MGRGIVQVVAESGFEVVVREVSPDLLDKGIGFIEKILTA-------------KLDKGKISESGKKEIRIKGTIDL-SVLRESDIVIEAVFEMDLKKEIFSWIDNIVKPEAILTNTSCLSVTEISSATKRPD-------RVCGLHFFNP--VPLMKLVEVIKTERTSEETYRKTVDFGIALGKETVK-SKDSPGFIANRILCPYLYLAFTKEEIDGSIKLEAGFPMGPFELIDLIGIDVCLDIGEAMYKETGIQELNPPALLKEMVK...................... 254
183 3.000e-53UniRef50_C7Q761 3-hydroxybutyryl-CoA dehydrogenase n=403 Tax=Actinobacteria TaxID=201174 RepID=C7Q761_CATAD  ali  14  9.......................................................GAGLMGSGIAQVAAAAGYEVALRDVTDAALKRGADGIRASLEKFASKGRYTAEEV-----------EAATARVSTTTDLAEAVADADVIVEAVFENEVKQDIFRELDKLAKPGAVLTNTSAIPITQIAAVTSRPQDV-------IGTHFFSP--VPMMQLCELVRGYKTSDETLAKARAFAEETGKTCIVVNRDVAGFVTTRLITALVVEAVKLYESGVATAEDIDHTMGPLATADLTGVDILRDATRNIYTETQDEKFSPPELMNRMVTAGDLGRK............... 275
184 3.000e-53UniRef50_A0A1V5VKL4 Prephenate dehydrogenase n=1 Tax=Elusimicrobia bacterium ADurb.Bin231 TaxID=1852873 RepID=A0A1V5VKL4_9BACT  ali  14  7.......................................................................................GVGLIGGSIGLAIKRSGLKDVCITGVGRNIKNLKIAQKLKASITTDLQKGVSSADVVFVCVPLSSMV-GITQKVIMFSKPGAVITDVGSVKGFVVSEIEKFIKKSRMDASQIRYFVGGHPIAGSEKTSVRVILTPLTDTKALNLIKMIWASLGAFIKIMSPERHDRVVAYTSHLPHVVAFALVKTVNH--------FEFSGSS----FRDTTRIVSSDPMWADIIFNNRKNVLPAVKDFRKIEKSGSRDELLKIFKKTK. 272
185 3.000e-53UniRef50_C9PQE2 T-protein n=9 Tax=Gammaproteobacteria TaxID=1236 RepID=C9PQE2_9PAST  ali  15  73.........................................................................DLIEDILRRVMRESYTRENQFGFKTVNSDINKIVIVGGKGKLGSLFLRYFALSGYSVSVNAGEILENADVVIVSVPIS-CTIETIERLAPYLTDNMLLTDLTSIKRAPLEKMLEIHKGA---------VLGLHPMFGPDMAKQVIVRCDGRFPERYQWLLEQMQMWGSRLYQVSAEEHDKNMTYIQALRHFSTFANGLHLSKQPISLAKLLALSSPIYRLELAMIGRLFAQDALYADIISDKPENLKQTYEESLKFFINDDKEGFIHSFEQVK. 352
186 4.000e-53UniRef50_A0A256ZT07 3-hydroxybutyryl-CoA dehydrogenase n=5 Tax=cellular organisms TaxID=131567 RepID=A0A256ZT07_9ARCH  ali  14  1................................................MRKIVVVGAGMMGSQIAQLFAEKGYSVSLVDVSDERVQLGINSIKDRLDKFFVKKGKITQE----------QADAILAKIKGTTNLEEACKDVDFVVEAVFEDNLKKDVFKRLDQATPKHTILANTSSLSITEMAKVTSKPD-------KVVGTHFFNPVAV--MRLVEVVKG-LTSDETVNVTMELMKKLGKTPILC-KDSPGFVANRVYAGLIQEALWCVYTGVASPKDVDTPMGPLELMDYTGGWDIALTMSKLYMEEFGPRYAPCPLLFELVRAGYLGKK............... 273
187 4.000e-53UniRef50_UPI0008EA291C bifunctional chorismate mutase/prephenate dehydrogenase n=2 Tax=Succinivibrio dextrinosolvens TaxID=83771 RepID=UPI0008EA291C  ali  12  71...........................................................................LLSDVMKRLLRESYKATDFSYPKTLKESGDIVIVGGNGGMGRVFSRYFEASGYKVFSKAPEYLKNAKVVIVTVPI-DVTVEVIQKLSPLLREDQLLCDFTSVKAPIVDAMMKYHKGP---------VLGLHPMFGPDVKKQVIVTVPQRDEKASEFLVEQFRIWGAKIVKSEAADHDKAMSIIQALRHFGTYSYGSFLQSLNPDLKRLIELSSPIYRMELMMVGRLFAQDPLYGDIIMANLELIEKFVRSLSKIVKDKDLDAFTERFLKTRE 352
188 4.000e-53UniRef50_A0A075GIN7 3-hydroxybutyryl-CoA dehydrogenase (PaaH, hbd, fadB, mmgB) n=97 Tax=cellular organisms TaxID=131567 RepID=A0A075GIN7_9EURY  ali  13  3...................SPASRLQPDWTTNRLSKAHAPPYTRQRVEISSIAVLGAGQMGNGIAQVAACAGYEVTMIDIEQRFVDHGMASIESSLAKLVSK-----------GRMDEEDAKAALSRVRACTDRGEA-GDSDLVVEAIPIPELKFSTFSELDDICKPEAILANTSSISIDDIAASTNRPD-------RVIGMHFMNP--VPIMKLVEIINGSQTLPEVNAAVVEAAERMGKTALSCN-DSPGFVSNRILCPMLNEAILTLQEGVAEPEAIDHPIGPLALADLIGLDTVLHIMNVLHEGLGDDKYAPAPLLVEMVEQGKLGRK............... 303
189 4.000e-53UniRef50_A0A2H9PCV8 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=3 Tax=Candidatus Desantisbacteria TaxID=1819803 RepID=A0A2H9PCV  ali  13  24.....................................................................................................RKRRLADKVIGLGRNPVKLRRAKVLGAEGYTDFDKGLKNAGLVIVATPVG-LIPVMIKRAFPYLEDGSIITDVGSVKCQLIRKIE-------RFLPQRIHFVGAHPIAGLETFGVELTPTPSTDANALRVIGEMWKGIGARVLLINPVQHDELLAFTSHLPHLIAVSLIEVLCNLNKKYKNTKEFIG----GGFRDTTRIAGSPIMWRDICLANKKEILNALRKFKEIISNEKWDMLLRKLIRAKK 280
190 5.000e-53UniRef50_A0A2P9GZF2 Prephenate dehydrogenase (Modular protein) n=4 Tax=Syntrophobacteraceae TaxID=213465 RepID=A0A2P9GZF2_9DELT  ali  12  18.....................................................................................................KRSVIGIIGGQGEMGRLFSKFFSSHGFHVPLTPEQAVGESDIVIFAVPLHQ-TVEIIRRLVPHTRPGQLLMDLTSLKNAPVKEMLKSPAS----------VVGLHPMFGSSFNGQTLAACPVRGQAQWRKLRALFTSSGIRVKECSPEEHDRMMGIIQVLFHLTTMLIGRTLRELDADISETMNYTSPSYRIEMNLVGRIFAQPELYAAITQMNPEEILTTLKDGLKVYRSGDLKGFIEDFE.... 266
191 5.000e-53UniRef50_Q7NSL5 Probable prephenate dehydrogenase n=20 Tax=Proteobacteria TaxID=1224 RepID=Q7NSL5_CHRVO  ali  15  8.................................................................................DTLVVAGVGLIGGSFALALKRAGRV-KTVIGVGRTLANLEKALTLGVEISQDIAAVAHRADMVLLASPVGQM-GALMAALAPGLKPGAVVTDGGSTKSDVVELYRRHLPGHLPW------CVPAHPIAGSDMSGRRVVLTPLTAPAAVEAVADLWRACGAEIHCMDAAEHDAVFASVSHLPHLLAFAYVDRVAA-KANAERCFDFA----ATGFRDFTRIAGSPEMWTDISLANRDALLAELDRLAALLEAGDADGLNRLFGEAR. 282
192 5.000e-53UniRef50_A0A2G9LU08 Uncharacterized protein (Fragment) n=1 Tax=Candidatus Woesearchaeota archaeon CG11_big_fil_rev_8_21_14_0_20_57_5 TaxID=1974469 Re  ali  8  12.......................................................................................................KVIGIVGGTGRMGQLFAGILERRGHRVALTPEAMVPQCDVVVITVPI-AVTEQVIRQVGPLVRKDALLMDLTSLKEFPLNAMLQRCTGS---------VVGTHPVFGPSVQGQTFVVCPGRGDAWHKWVLDFLCSEGAVIKETDAATHDRHMAIIQGMQHFSTIGLGMALRRLGMKPEALLEYSSPIYRIRLDMVGRILGQDPLYADIELQNRHAYVAALRELQNVLATPDRDGFLRFFQEA.. 260
193 6.000e-53UniRef50_A0A1W2CZU7 3-hydroxyacyl-CoA dehydrogenase n=14 Tax=root TaxID=1 RepID=A0A1W2CZU7_9DELT  ali  13  1..............................................MEIKKITVLGAGIMGAGIAQTAAQAGFDVMIRDMEDRFVENGLATIKANLDR-------------SVSKGKLAQEEATKIRITGTTDLNEAAQDADMVIEAIVEMEVKKQVYEELDHICKKETIFANTSGLSITEMASVTTRPD-------KVIGMHFFNP--VPVMKLIELIKGFTTSDETLKIATAYVNTIKKTPIEV-KEAPGFAVNRILCPMINEAIFVLAEDIASARDIDKAMGPLALADMVGLDTMLMVLEGFHKELGEDKYRPAPLLRKMVRAGHLGRK............... 275
194 7.000e-53UniRef50_A0A1Y5I322 Bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase (Fragment) n=1 Tax=Oleispira antarctica TaxID=  ali  13  32.....................................................................................................KLAGAVNSISGYDRNLDSMQQALQAGLDYSLEITDVVKDADLVIISVPILAVA-SVLEQIKSAISDKAILTDVGSVKGCVAQNITEILGADFER------FVLGHPIAGSERSGVKIILTPETSERALDLVADAWNITGAVVELMSVQHHDEVLAATSHLPHLLAYSLVDTLANSHEN-KDIFNYA----AGGFRDFTRIASSSPMWRDIFVGNKEEVLKALDLFTA-----DLQQLREVVASEDK 276
195 7.000e-53UniRef50_A0A1W9USD9 Uncharacterized protein n=1 Tax=Anaerolineaceae bacterium 4572_32.1 TaxID=1971623 RepID=A0A1W9USD9_9CHLR  ali  15  1................................................MNKVVIVGAGTMGSGIGYVTARAGYQTNLYDPFPKVLEKARAYHKKLIDRAVEK-------------GQLTLDEAYWACVVYTDDLPAALHGADLVIESVPEKELKKEVFQQIEQLAPPGAILTNTSSLPVTELA-------GVVGNPGRVVGTHFFNPA--PVMKLVEIIVGLNTNQETVDEVVEFVKSIDKEAVIV-KDLPGFVTTRV-GLMLISEAIFADLDKAMKLGYNLPMGPLALADLVGLDVVLHILDALFENYKDSRYRAPILLRRMVQAGKLGRK............... 273
196 7.000e-53UniRef50_A0A150IW46 Prephenate dehydrogenase n=9 Tax=Euryarchaeota TaxID=28890 RepID=A0A150IW46_9EURY  ali  13  4.........................................................................................................VGIIGGTGKLGGLFKKIFEEEGHEVTTSLEELIRKSEIVIVSVPIES-TTGVIREIVPFMSEGKLFIDLTSLKVGPINEMLKSKAD----------VLGTHPLFAPDIKGQTIILCPERNKDLYKIFNSILVKKGANIVEMTPEKHDKMMAVIQGLTHFSAIVLCHSLKDLDFDIKKSFECTSPVYRLTLDMAGRILNQPELYADISLLNPKTYIKTAEALYKKIENKDREGFIEFFEEASE 253
197 8.000e-53UniRef50_A0A1F3BE80 Uncharacterized protein n=1 Tax=Armatimonadetes bacterium RBG_16_58_9 TaxID=1797287 RepID=A0A1F3BE80_9BACT  ali  16  9..............................................................................ILFETVAIVGVGLIGGSLG-MAVKTRSMAGRVIGIGRTEQKLMRAKILGAEYSLDFENGAAEADLVVICTPVRLIVPA-LEKMARSLKAGCIVTDVGSTKQEVVS-------GASRFVRDEISFVGGHPMAGSEQAGVVLTPGDNTDLEALGKMAALVEGLGANVEIMTPEEHDRSAAVISHLPHAMASALLQLAEDSHRANGKTFRLA----AGSFRDLTRVSESDPLWRDICLTNAGALSSAIGDFADILRAGDEEAIERFFEKA.. 285
198 9.000e-53UniRef50_A0A2R7YA26 3-hydroxyacyl-CoA dehydrogenase n=4 Tax=TACK group TaxID=1783275 RepID=A0A2R7YA26_9ARCH  ali  13  9.......................................................GAGTMGHGIAEVAALSGYYVLLNDISDEILWEAVKKIEWSLRKMVEKGK----------LDEAGLALALS-RVKTTTSLEEAVNGSRLIIEAVPENELKKEIFSKVDKIAHPDAVLTNTSSLPISEIAAATYRPD-------KVVGIHFFNPPVI--MPLVEVVLGDRTSRQTVELVLEFVKTLGKQAIVCRKDVPGFVVNRILEAVHRGEASVLEIDSAVKYKARLPMGLFELSDYVGIDVL................................................. 241
199 9.000e-53UniRef50_A0A256ZSK5 Uncharacterized protein n=1 Tax=Candidatus Altiarchaeales archaeon ex4484_2 TaxID=2012506 RepID=A0A256ZSK5_9EURY  ali  15  13............................................................GAGI------KGFRRRGRKMKAAVVGAGV--IGEFFAELLQEKFRVVISDIDASRGE---AVASRLGLEYRVNNIEAVGDADLVLVSTPIKE-TPQVVESIAPAMKKGSLLMDATSIKSHV-------RESFIRTGRKDIDYISIHPMFCPPTKLEEIIVIPVQGDSWINEIKEFFTSKGLRVHESTVERHDEIMALIQVLIHLSFMGINSTIKELGYGEDDLRPFMGKFHRVLFDFIPRITAQNEMYASIQLENPESLKNKIDSFRQLIKGKNLDRLVKELEDMSD 289
200 9.000e-53UniRef50_UPI000C04B46F uncharacterized protein LOC111320166 n=1 Tax=Stylophora pistillata TaxID=50429 RepID=UPI000C04B46F  ali  13  1..............................................MMLKSVGVIGSGQMGRGIAQVAATSGYFVILSDVSEEALDLAQKEIQKSLSKLHEKGKISESPDQIFSRLKM-ETTVESLGV------------CDLVIEAVPEEDLKGQVYEKLAPYLKENAILASNTS------YIGISGLGESSGHPHRFLGVHFMNP--VPLMPLVEIIVGDKTEQDVCDVAYRFVESLGKT-SVTSRDRPGFIINRILMPMINEAIFVFSEGVATVEDIDHPMGPLKLADFIGLDTCFSIMGVLYAGFQDEKYRPCDLLKNLVR...................... 267
201 1.000e-52UniRef50_H5SR96 3-hydroxyacyl-CoA dehydrogenase 2/enoyl-CoA hydratase I 2 n=1 Tax=Acetothermus autotrophicum TaxID=1446466 RepID=H5SR96_ACEAU  ali  15  13.......................................................GAGTMGHGIAEIAALAGYKVKMRDISEEFVKRGYDQINWSLKKLAEK-------------GTISPQKADAALKLITVDLKEAVSDADIVIEAVPIMSLKLAIFKEIDTLSPHHAILANTSSLSISELGRATKRPD-------KVVGMHFFSPVV--RMALVEVIRGEKTSEETMQLIVELAKKLGKTPIRVEKDVRGFIVNRILGPYLFEAGWLVSRGEATIEEIDSRMKFYEPMGPFELQDLTGIVGYNLMEAGFPI--PPVIEQAVKEGRLGRKTGR............. 276
202 1.000e-52UniRef50_P41938 Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3 n=67 Tax=cellular organisms TaxID=131567 RepID=HCDH2_CAEEL  ali  12  3.............................SSTCTAAVRGLSTTAQLSKINNVTIIGAGLMGSGIAQVSANAKLNVTVVDSNQSALEKAQQGIANSLKRVAKKKH------ADDAAAQTALVSSVLDRIKMSTNVSDSVKDADLVIEAIVENDIKRKLFAEVEVAAKPTTLITNTSSLRLADI-------GLNLKDKSRFGGLHFFNP--VPMMKLLEVVRHTETSDATFNQLVDYGKTVGKTTVAC-KDTPGFIVNRLLVPYMFEAASMEDIDVAMKLGAGYPMGPFELSDYVGLDTCKFIMDGWHAYPEEVAFTPSPLLNSLVDSGKNGR-KSGEGFYKY...... 308
203 1.000e-52UniRef50_A0A2A2RI42 Prephenate dehydrogenase n=3 Tax=Verrucomicrobia TaxID=74201 RepID=A0A2A2RI42_9BACT  ali  16  20..................................................................................................LALKTRKLAGRVEGYVRRPASIAECERLGVSATTDLLAAVRDADLVIFCTPLAQM-RALAEQCSPALRPGTLVTDVGSVKGSVVTELEPIFAKVSAP------FIASHPMAGGEKTGCIVTPGAKTPLKLVKQMEEFWAALGGRPMRLTPDQHDALVARSSHLPHVVAAELANYVLSPAHPKEQPALCAT-----GFRDTTRIAASPEMWRDIALANRKHLARAL-----GVFIEDLQEFQRALDSGE. 266
204 2.000e-52UniRef50_S3NMA8 Bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase n=140 Tax=Pseudomonas TaxID=286 RepID=S3NMA8_PSESY  ali  13  16..................................................................................RLVVVGLGLIGGSFAKGV-RESGLCGEVVGVDLDPQSRQLAVELGVRCEADLATACRGADVIQLAVPILAM-EKLLALLAPIDLGHAILTDVGSAKGNVVRAARQAFGHMPSR------FVPGHPIAGSEQSGVEVILTPLTDPQAVAIVDQLWSALGADVEHMQVERHDEVLAATSHLPHLLAFGLVDSLAKRNENLD-IFRYA----AGGFRDFTRIAGSDPMWHDIFMANRDAVLRTLDSFRT-----DLDALREAVDAGD. 277
205 2.000e-52UniRef50_UPI00057070AC prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Ghiorsea bivora TaxID=1485545 RepID=UPI00057070AC  ali  16  22.....................................................................................................KEKGAVGKVIGAGRNEGNLKLAQSLGISWTTSLTDAVKDADVVLLAVPMGAYA-HVMQTIAPALKAGVIVTDAGSTKRHALAAAAKYL-------PSHAHFVAAHPLAGTEKSGCIITPNDSTHEQALTVVKHIWESAGANVLTMPADEHDKLLGAVSHLPHLAAFALVNAVNKQKTDNFDPMAYA----AGGFKDFTRIASSPEMWRDITLAN................................ 239
206 2.000e-52UniRef50_A0A0X8GMZ7 Prephenate dehydrogenase n=3 Tax=Betaproteobacteria TaxID=28216 RepID=A0A0X8GMZ7_9BURK  ali  14  21..................................................................................................LALKRAKCVEHVVGVGRNPDNLARALELKVEASNDAALAVQGADLVLLSAPVGQMA-ALLQQIAPHLPLHCIVSDAGSTKQDVCALYRQYLPQHLSR------CVPGHPIAGSELSGRRVVLTPLTEPESIELLKSLWQACGAQVFEMSAAEHDGVFSAVSHVPHLLAFSYMNAVLD-RHNAALCFDFA----ATGFRDFTRIAASPEMWRDITLANKEAIL-----LDLKANAAQLLALIDCIENHD. 267
207 2.000e-52UniRef50_F6B985 Prephenate dehydrogenase n=9 Tax=Peptococcaceae TaxID=186807 RepID=F6B985_DESCC  ali  14  12...............................................................................LFKKVVIAGVGLIGGSLG-LALTERRLAAEVVGVDPNRDNLNLAVTMGVHRAASLVEALPAADLFILATPVG-VTLGVLEMAVPFLTPGTIITDVGSVKGRLVERAEKML-------PAGVHFIGGHPMAGLEVSGVILTPTKNFDPVALQKLKRLVKEMGAHPVELAAEQHDRLVAMISHLPHLLAATLVNTVAAEP-----SSDMLLQLAAGGFRDTTRIAAANAMWRDILLTNRDMVLRQLAEMELAINNFDQTALVAVLERARE 287
208 2.000e-52UniRef50_A0A2H6ICL7 Cyclohexadienyl dehydrogenase n=3 Tax=Bacteria TaxID=2 RepID=A0A2H6ICL7_9BACT  ali  16  2................................................................................................................................................VLATPVGCFK-SVIEEVGPFLKKGAIVTDVGSVKGRLAREME-------GLMPEGVTFVGGHPIAGSDRSGIIITPTEHTPEEAVRKVTELWTAIGAEVCFLSPEEHDLVFALVSHLPHLIAYTLVNTVSDVNPEYIH-------YAGKGFKDTTRVASSPELWRDICFKNKENLLESLTSMVDALKRNDSEELESLFEKAQR 210
209 2.000e-52UniRef50_A0A2H5X7I1 Prephenate dehydrogenase n=1 Tax=bacterium HR16 TaxID=2035411 RepID=A0A2H5X7I1_9BACT  ali  12  7.................................................................................DRLCIIGVGLIGGSLGMAVRR-RGLANRVVGVGRNAERLQIALQAGADATTSLQEGVTGADLVVVCTPVGLIVPTI-RLFHQWLSSECVVTDVGSVKNTIVQQATDLLGER---------FVGGHPMAGSEQTGVHLTPTETTSPDALQKVTALAQGVGAQVITADPNEHDRAVALTSHLPHALALALVHVAENTPYP-----QLIGGSFRDGTRVA---ASSPELWRDIFLHNREHVLWAIDEFRSAIADEDAETVQRLFTDAR. 274
210 2.000e-52UniRef50_D9Y356 Prephenate dehydrogenase n=10 Tax=Proteobacteria TaxID=1224 RepID=D9Y356_9BURK  ali  15  7.......................................................................................GCGLIGGSMA-LSWKRAGIVDEVIAFGHNPATLQKALDKGATVTTSMEEAVKDADIVVSAVPVEAM-ESVFTEMAPFLKSDAVVTDVGSTRQTVIAAARKGLGD------KFHQYAPAHPIAGGEMPGVVVISTPGMDPKVVTFIEEAWRKAGARVQAMSPLQHDLTFASVSHLPHVLAYALVDMIAREENAQEKLK-----MAGAGFRDFTRIASSSPMWRDICLSNREALSHELKRYRA-----SLDTLQKYIDESD. 263
211 2.000e-52UniRef50_A0A1V4QN93 Uncharacterized protein n=3 Tax=Deltaproteobacteria TaxID=28221 RepID=A0A1V4QN93_9DELT  ali  13  4........................................................................................................KVGIVGGQGQMGQWFKRFFEEQGLEVSTTPPEVARQVDVAIISVP-MHITEQTIRDISPHLRPEALLMDLTSLKKDPMAAMLQYFPG---------EVVGTHPLFGPGIKGSIMVLCPGRGQRWFNWLKDLLTRAGAIVQITTPEEHDIMMSVVQGLTHFVLIAMGTTLRTLGTKINELDDFATPTFRKLFGQVQHLFNQSDLYACIQLRNQAAFEAAVADIRRIVANQDAPGLISLMEENRR 253
212 3.000e-52UniRef50_A0A2D5CDC2 Bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase (Fragment) n=85 Tax=Pseudomonadaceae TaxID=135  ali  12  4..................................................................................RLVVVGLGLIGGSFAKGL-RSSGLCREVVGVDLDAPSRVQAVELGVRCEADLATACIGADVIQLAVPILAM-ERLLAELAKLDLGNAVLTDVGSAKGNVVRAAREAFGAMP------ARFVPGHPIAGSEQSGVEVILTPLTDAQAVALVEQLWRALGADVEQMQVDHHDQVLAATSHLPHLLAFGLVDSLAKRSENL-EIFRYA----AGGFRDFTRIAGSDPMWHDIFLANREAVLHNLDLFR-----DDLDALRAAVDAGD. 265
213 3.000e-52UniRef50_A0A0H4I1E8 T-protein n=8 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A0H4I1E8_HAEDC  ali  13  12................................DQIDQALIELLSERLKIVTQIGKVKYEDGLPIATVLANRQYDFIEDILRRVMRESYVNENKFGFKKTNPLIKKIVIVGGRGKLGGLFGSFLKQSGYYIEPNAEQIIANSDVIIVCVPIAS-TLETLECLAPYLTPNMLLADLTSVKTAPLKKMLAVHRGA---------VIGLHPMFGPDIPNQVVLYCPGRFADQYEWLLEQIRIWGAKIEVIEAEEHDQAMTYIQALRHFATFSMGLHLSKQPIQLSQLLTLSSPIYHLELAMVGRLFAQDGLYADIISNKPEAVLKSLQETYETSLNNDKTTFIETFNKVHK 348
214 3.000e-52UniRef50_A0A1Z9MD98 Uncharacterized protein n=3 Tax=Opitutae TaxID=414999 RepID=A0A1Z9MD98_9BACT  ali  14  23......................................................................................................EKKLAKEIHLWARNEEKRARCLKNCDYVHESLENAVKDSDFIVLCTPVDSIIP-ILKTIAPYLTPGTLVTDVGSVKESICFQAKTIP------NNNHFHFIGSHPMAGSEKSGMEITPTEHTEPLALEKVTQFWSALEMHPVHMAPESHDSLIAKISHLPHIVASILAASISDIP---DAQFQYAG----GGLKDTTRVAGGSPLWQSILSQNSDQILKAIDQFEKTLESQDLNSLHKILNEGQ. 275
215 3.000e-52UniRef50_F5ZDJ9 T-protein n=55 Tax=Gammaproteobacteria TaxID=1236 RepID=F5ZDJ9_ALTNA  ali  13  72.........................................................................DLTEDLLRRIMRESYHTQNNRYLG-VNADVGTIVVIGGAGALGKIFVSLFERSGYSVSVVEREVLSTAALVVVAVPIN-LTEQVIGQLS-MLPESCILADITSIKVKPIEAMMAVHKGP---------VVGLHPMFGPDAPGQVVVVCEGRNESAYDWLIAQMKIWGATIHSSTAEEHDKSMAYIQVMRHFNTFVYGEHLRGEDPDLESLTMFSSPIYRLELAMVGRLFAQPELYADIIFNNPENF------ALLRRFYDRFGLALNVLEKGDK 340
216 3.000e-52UniRef50_A0A2N9NJJ7 Prephenate dehydrogenase n=8 Tax=unclassified Verrucomicrobia (miscellaneous) TaxID=417295 RepID=A0A2N9NJJ7_9BACT  ali  17  23.....................................................................................................KQRRLAETVIGFVRRAASVRECERLGARATRDLEQAVQGADLVVLCTPIAQM-RSLVEQMLPALSKGAIITDVGSVKDPLVRELE------PLAASAAAHFIGSHPMAGAEKMGVVVTPTRKSNPVALRKVERLWQSIGGRLLRLAPAAHDELVSRTSHLPHVVAAELANFVLSPEHPKEQP-----SLCANGFRDTTRIASSPEMWRDIALANRGNLADALASFVA-----NLRSFQQALEQGDE 267
217 3.000e-52UniRef50_A0A1G1LLK2 Uncharacterized protein n=7 Tax=unclassified Candidatus Omnitrophica TaxID=1047005 RepID=A0A1G1LLK2_9BACT  ali  14  7...............................................................................LFRKVTIVGVGLIGGSIGLAIRKHN-LAREIVGVSQKSTSLDYALKAIDRGFTDLQAAIQHSDLIILATPVLTII-NFLVKLAPLIRHSCIITDVGSTKKAIVEAAHKIL-------PNHAFFIGSHPLAGSEKMGVVITPTDKTNRLARDKIKHFWAKVGADVKVLTPEEHDKALAFISHLPHLLAYGLIDSIPSE----------FIPFAAQGLKDTTRIASSSPMWNDICLSNSEYILKTLDEFV-----KNIGAFRRAI..... 261
218 3.000e-52UniRef50_A0A2N1JE05 RBR-type E3 ubiquitin transferase n=1 Tax=Malassezia vespertilionis TaxID=2020962 RepID=A0A2N1JE05_9BASI  ali  13  551.......................................................GAGLMGAGIAQVLADVGYNVTLSDVSDKALANGQSIISKSLSRLAKKKM--------ADKSSEEQAQYVKSIINVTTDASNAVKDTDLVIEAIIENQIKQDLFSFVDAKAPKDAIFANTSSLSIADVAKSTQR-------ESQFGGFHAFNP--VPQMKLIEVVRIPATSDETHATLVQVAKKMGKVPITC-IDSPGFVVNRLLVPYQLEAIRLVERGVASSEDVDYPMGPFELADLVGLDTLDYIAEG---WRD..................................... 798
219 3.000e-52UniRef50_A0A2E0SDY0 Prephenate dehydrogenase n=10 Tax=Planctomycetaceae TaxID=126 RepID=A0A2E0SDY0_9PLAN  ali  13  30.....................................................................................................RQRGLSDRVIGIGRKPARLRKAKQLGAETTTNIERGVSEADFVIVCTPVQYVVEQV-REISQYVRSGTLITDVGSTKQTIVEGLT---------VLENGHFIGSHPMAGGERGGVTIVVTPETNKAAQSRISKFWKSLGARVMELDCKEHDRAVAVISHLPHTLASVLSTQANAKQLAL----------AAGGWIDTTRIAGADPLWLEILRDNNKQVIRAVDRFL-----DDLHKFRDALE.... 262
220 3.000e-52UniRef50_A0A2H5YM19 Prephenate dehydrogenase n=2 Tax=Bacteria TaxID=2 RepID=A0A2H5YM19_9BACT  ali  17  25....................................................................................................KAGPGPEVEVIGYDRNRTVAAKARRLGARAGADLAEAVAASPLVVIATPVLAI-RQTLERIAPHLQPDAVVTDTGSTKAMVMAWAGELL-------PPGVNFVGGHPMAGKETQGVDHAPSPEARQEAVDLVTEMVRRVGGQPLLISAEEHDRYVAAVSHLPLVVSVALFNLVRSSP---DWPRLAA--LAASGFRDVTRLASGDPMGHDICVTNREQLLHWLDRF-----QEELTRFRELI..... 264
221 3.000e-52UniRef50_F4HAQ5 T-protein n=46 Tax=Bacteria TaxID=2 RepID=F4HAQ5_GALAU  ali  12  34.............................RVKHQHGLP-IYVPEREAAMLLERRQEAEKMGLS---------PDLIEDVLRRVMRESYHSENQYGFKTVNPEIKKIVVVGGRGKLGGLFARYLSNSGYRVEDDWQQAAEGANMVLVSVPI-TVTESVIEKLQPYLHPEMLLADLTSVKTAPMAKMMEVHQGA---------VVGLHPMFGPDMAKQVIAVCEGRYPERYQWLLDQFYIWGARLYQVTPQEHDHSMTYIQALRHFSTFANGLHLSQQPVQLKNLLALSSPIYRLELAMIGRLFAQDPLYADIIMDKAENLEKSYQQALQFFENGDKQGFIKAFQQV.. 346
222 3.000e-52UniRef50_A0A1F9KWU9 Uncharacterized protein n=8 Tax=unclassified Deltaproteobacteria (miscellaneous) TaxID=122706 RepID=A0A1F9KWU9_9DELT  ali  12  1...............................................................................MFRRMVIAGVGLIGGSLA-LAARKRGLVEEVIGYGRGEKNLRVALKKGMSYFLRSHEIPFETDLLVLGTPVRSTVP-LMEEFMGSLHPGCVVSDVGSVKAEIVRDMEKLL-------PDTLPFVGAHPIAGGEQWGQRCILTPHTDRAALKKLKSFWRKVGAKVEIMDPQLHDRILGVVSHLPHVLVYALVNLLSRTKVDRVDLKEYCG----GGFKDFTRIASSPELWRDICLLNREAVIKSLERMNRLIRKGQGALLEREFASANE 278
223 3.000e-52UniRef50_A0A0H4KY82 Prephenate dehydrogenase n=353 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A0H4KY82_9RHOB  ali  14  12.......................................................................................GLGLIASSMAHAMRRG-GVAAEISGYARSQATRDTARQLCDTVCDSAEAAVEGADLIVLAVPVGAMGV-VAEAIAPHLKPGATVIDVGSVKAAVVEAV-------GPHVPDGVHFVPTHPMAGTEHSGPEIVPPDGADRAAVERVEAYWQALGANCERMEVTHHDLVCAVVSHIPHLIAYTMVGADDLSRVSDQEVIKFS----AAGFRDFTRIAASDPMWRDVFLTNKEATLEMLGRFTEAIRTGDGEELFDYFTRTR. 281
224 4.000e-52UniRef50_F4BUZ7 Prephenate dehydrogenase n=14 Tax=root TaxID=1 RepID=F4BUZ7_METSG  ali  11  37.......................................................................................................................VEVAERLGVRYAHDMMAEVEESDVVLVSVLIEK-TVEVIRQVAPRMHSGSLIMDVTSVKSGPVRAMK-------TYAPKGVEALGTHPMFGPTMPGQTIIFTPVKTGKWLGVIRSLFESDGAKIEILEAEEHDETMAVVQALTHFAYISIGAALKALDFDVQRSHRFMSPVYEIMIDFVGRILDQNPLYASIQMAARQAFVSECMRLCEKTDDGDMEGFKQMMREA.. 265
225 4.000e-52UniRef50_L0K8M4 Prephenate dehydrogenase n=3 Tax=Halobacteroidaceae TaxID=53434 RepID=L0K8M4_HALHC  ali  14  3.................................................................................EQVAIIGVGLIGSSLGLALQDVTEV-KSVVGIDNNSRHVQEALDIGIDEEATLKEGVQEADLVVLAVPVGIIKDLVIK-IAPYLNSETIITDVGSTKLQLVKQLEEIVEDNT--------YIGGHPMAGSEVSGPALTKSNKTDEEALAKLKNLVKQLGAQPLIISPQAHDQIVGITSHLPHVVAVSLMEVVA----DYSKESDLLTSLIGGGFRDTTRISAGDPMWKDIFLNNRDQVLEGIDAF-----SNNLAELRELIASKNE 264
226 4.000e-52UniRef50_A0A1B1YN80 Prephenate dehydrogenase n=3 Tax=Clostridium stercorarium TaxID=1510 RepID=A0A1B1YN80_CLOSR  ali  10  19..............................................................................................SLVKAVKR-KGLCETVVAYDQNENTMELALKEGHKAAQGIDETFKGCEMVFICVPVKSI-PEIVKQLDKIVESDCILTDVGSTKGNVMETVKK--------LKLSCPFIGGHPMAGSEESGYRYVLTPGTDEVYINKLSEFLKLLGALPVIIDPHVHDYATAAISHVPHVIASALVNTIK----GLDGSDRLMHTLAAGGFRDITRIASSPAVWESICLTNKDNIIRVL-----GEFAKNINSFVEALNSNDD 268
227 4.000e-52UniRef50_A0A223E617 3-hydroxybutyryl-CoA dehydrogenase n=12 Tax=Bacillaceae TaxID=186817 RepID=A0A223E617_9BACI  ali  13  1..............................................MTIQTVGVVGSGTMGSGIAQTCVQHGFRVLLYDLNDAIVQKAFTQIKKRLNRLVEK-------------GKMEEQTFQDSRIETCTDL-SLMKACDLVIEAVPEKNIKKEIFQALDEHCPEQTILTNTSSFSVTEIASVTK-------TGERVAGLHFFNP--VPLMPLVEVVRGVKTSEDTLKKLAQFVSSLHKDPVVCE-DTPGFIVNRIARPFYNEALKIAGERLAKPEQIDRIMGPFELQDLIGIDVTTEIVYNS--FFGEERFRPHYLQQRMVQSGKLGRK............... 275
228 5.000e-52UniRef50_A0A285MYW1 3-hydroxyacyl-CoA dehydrogenase /Enoyl-CoA hydratase n=1 Tax=Natronoarchaeum philippinense TaxID=558529 RepID=A0A285MYW1_9EURY :_  ali  15  13.......................................................GAGNMGHGIAEVAALSGYEVNIRDIKEEFVQNGYEQIEWSLNKLEEKEQ------IGEGEADATLDRVTPL-----VDVGEAVGDADVVIEAVPEMDIKKDVYQEVEEHAPDEAIFTNTSSLSITELSEVTER-------SGQFCGMHFFNPPV--RMQLVEVISGAHSDEETLDVIEGLAEEFGKTPVRVHKDSPGFIVNRILVPLMNEACWLVHEGEATKYDIGLPMGSFELGDQVGNDVSYHVLEYMHEELGD-AYEPCPLLAEKVENDELGKK............... 278
229 5.000e-52UniRef50_A0A2A5FN97 3-hydroxybutyryl-CoA dehydrogenase n=215 Tax=root TaxID=1 RepID=A0A2A5FN97_9FLAO  ali  15  8.......................................................GSGTMGNGIAHVFAQNGHKVSLVDISQDALDKAMATIGKNLDRMVAKEKI-----------SESDKENTLANITTSTDVVSGSKDADLVVEAATENDIKLDLFRKLDENCKPECILANTSSISITKIASVTSRPD-------KVIGMHFMNP--VPVMKLVEVIKGYSTSSEVMEITMETTKKLGKVPVEVN-DYPGFIANRILLPMHEGVAGVEEIDTVMKLGMAHPMGPLQLADFIGLDVCLAIMNVLYDGFGNSKYAACPLLVNMVEAK.................... 268
230 5.000e-52UniRef50_A0A1W9MDP5 Uncharacterized protein n=1 Tax=Candidatus Altiarchaeales archaeon A3 TaxID=1933927 RepID=A0A1W9MDP5_9EURY  ali  15  4...................................................................................VIIGGYGGMGQIFVRIFKAYGNVIITGPSREKGE---KTASDFGVKFSDDNRIAMS-ADITIITVPIEK-TIATIKEVAPLVKDGSLITDFTSVKTDVCDALLQ-------YTNKNAEIISIHPMFGPTISGQIFILCPLRTEKWMPVIEKFLNDYKAKFVTATPEEHDKAMSVIQGLTHFTYISIGYTLKNMDFNVKESRKFASPIYSLMLDIIGRILSQDPLYAHIQMENREKFIESAIVLNNAINSKDEKNFVNIMSSSAK 266
231 5.000e-52UniRef50_A0A2X1HF12 T-protein n=4 Tax=Cronobacter sakazakii TaxID=28141 RepID=A0A2X1HF12_CROSK  ali  15  35.............................EVKSRYGLP-IYVPEREASMLASRRHEAETLGVP---------PDLIEDVLRRVMRESYSSENDKGFKTLNPALRPVVIVGGGGQMGQLFEKMLTLSGYQVRIDWPQACADAGMVIVSVPV-HLTEAIIRKL-PALPEDCVLVDLTSVKNVPLQAMLEAHSGP---------VLGLHPMFGPDLAKQVVVYCDGRMPEAYQWFLEQIQVWGARLHRISAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPLYADIIMSNLALIKRYYQRFGEG.................. 327
232 5.000e-52UniRef50_A0A2K8L2G0 Prephenate dehydrogenase n=33 Tax=Proteobacteria TaxID=1224 RepID=A0A2K8L2G0_9PROT  ali  13  12...................................................................................LVIVGVGLIGGSFS-LALKRAGLVGRVTGVGRSRDNLELAQRLGIAWTHDVGEAVRDADVVLLAVP-MSAFESVFADMAASLSDHAVVTDAGSTKQSAIAAARKFLPNPSR-------FIAAHPIAGTEQSGCVLAPDPDSDPDALALVKALWHQVGSRVVCMGAAEHDDFLAAVSHLPHLAAFALVNAVRRQSYEGHDPFRFA----AGGFRDFTRIASSPEMWRDIALCNSDALVKQIDAFREALMAADGESIMNEFKAAKE 285
233 5.000e-52UniRef50_A0A2H9PQZ8 Uncharacterized protein n=2 Tax=Candidatus Woesearchaeota TaxID=1801616 RepID=A0A2H9PQZ8_9ARCH  ali  8  19.......................................................................................................KVIGIVGGTGRMGQLFAGILERRGHRVALTPEAMVPQCDVVVITVPI-AVTEQVIRQVGPLVRKDALLMDLTSLKEFPLNAMLQRCTGS---------VVGTHPVFGPSVQGQTFVVCPGRGDAWHKWVLDFLCSEGAVIKETDAATHDRHMAIIQGMQHFSTIGLGMALRRLGMKPEALLEYSSPIYRIRLDMVGRILGQDPLYADIELQNRHAYVAALRELQNVLATPDRDGFLRFFQEA.. 267
234 5.000e-52UniRef50_A0A2G4FQ02 Prephenate dehydrogenase n=1 Tax=Planctomycetaceae bacterium TaxID=2026779 RepID=A0A2G4FQ02_9PLAN  ali  13  9.......................................................................................GTGMIGGSIGLACKKAGHV-KRIIGYDTNPESLEASKALGISIEYKLEDAIKEADLVVFSMPVQAIAEEILRA-AKCAKEGAIFTDTGSTKAEICSLVKEKLLCMAPV------YVPAHPIAGSEKNGPTAILCPNTPAWALDKVASFWQAMGARIEKLSPEEHDKIFAFTSHLPHLIAYALAGLLEPRH----------APFTAGGFRDTTRVAGSDPLWTEIFKANKGPLLEALKGFQEGLKSNDFDALENLLTKAQQ 273
235 6.000e-52UniRef50_A2R2E2 Aspergillus niger contig An14c0010, genomic contig n=165 Tax=Eukaryota TaxID=2759 RepID=A2R2E2_ASPNC  ali  17  20........................................AFSTSPAVHAAEVKSLAGQMGLGIALVAAQAQVPVTLIDNSQASIDKGLKFADKLLDK-------------DVSKERLTRDAADAARARITPSLKDDLSSVDFVIEAVPIPDLKTSIFSKLAQIAPKHAILTNTSSISITKIAAATTTDPTDLQAPSRVISTHFMNP--VPVQKGVEIIAGLQTSQATKDTAIAFVQRMGK-VASVSADSPGFLANRILMPYINEAIICLETGVGGREDIDNPMGPLVLADFIGLDTCLAIMNVLHQETGDSKYRPSGLLKRMVDAGWLGKK............... 311
236 6.000e-52UniRef50_A0A2D8KW99 Prephenate dehydrogenase n=2 Tax=Acidiferrobacteraceae bacterium TaxID=2024893 RepID=A0A2D8KW99_9GAMM  ali  13  2.................................................................QVMAEKPF---LDDSQARITIIGVGMIGGSFA-LSLKGKGVVDEVVGYGRSRERLETAQNLGVRFSCDLTEAVAGADLIFLAAPIDASKX-LLKALVSLVGPEVIITXAGSVKQEXXAVARQSLXXHFPM------FIPGHPIAGKEKTGVRVVLTPVTNRHATQRVRRLWEIAGADVVEMDAVEHDRLLAMTSHLPHAVAFALVALLGEQQNAEE-----FFPXAAGGFYDLTRXASSDPMWRDIFLNNREPVLAGIDRIRELXRSGNGTELETIFEHARE 295
237 6.000e-52UniRef50_A0A1V5L7L3 T-protein n=1 Tax=Alphaproteobacteria bacterium ADurb.Bin438 TaxID=1852792 RepID=A0A1V5L7L3_9PROT  ali  12  1...............................................................................MFDKVTIIGIGMIGSSVA-LSLRDNKLAKEVVIYDHNHDYLIEAERLGNVYEKDLEKSVVNSDVVIICTPVKTF-YEITKVICPVMKKGAILTDVGSVKDEVIKQVLPNL-------HDGICFVPAHPVAGSEKSGPIITPFDKATKESILKIRKMWEAFGMKVEEMTPLHHDRNMAIVSHLPHMLAYNMVFTASKLEDEFEEIIKYS----AGGFRDSTRMASSPEMWRDIFLTNSKALFEIMESMQKLIEDKEADKLYDLFSETKE 279
238 6.000e-52UniRef50_A0A2M6Z5R8 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=2 Tax=unclassified Candidatus Hydrogenedentes TaxID=1046981 Rep  ali  13  3..................................................................................RIAIGGCGLMGGSIG-LRLKQLNAPPEIVGFGRTEATLKKALERNARYELNPADAVCGADFVLLCAPVKSIPQQM-SDIADNLLSNAIVTDVGSTKSWIVAEAEKRL-------PKRCRFAGSHPMTGSERDGIVVVITPLSDEKTILTIKDFWRMLGAIPIVLPPQLHDKIVASVSHLPHVLAALLVEVAAKRSSSTPRIWELA----AGGFRDTTRISSSNPLWRDICLTNKNALLEAIDEFKNALMKDDSKAIENFFYRAKE 277
239 6.000e-52UniRef50_A0A258MW03 Uncharacterized protein n=3 Tax=unclassified Thiotrichales (miscellaneous) TaxID=939858 RepID=A0A258MW03_9GAMM  ali  13  3.................................................................................ERLAILGVGLIGGSLA-LSLKQQGLVKQVVGYGRSKANLAEALALGIEAVESASEAARNADMVVMAVPIASM-RGLLAEIQPVLSATAVLTDVGSAKSCWIEDVLSVWQGVWPENA-----VPAHPIAGAEKSGVVITPHEQTGASALAKVTQMWQATGADVRCMSAEEHDQTFAWTSHLPHLLSFALVDMFSQ-RQDVERLFDYT----AGGFRDFTRIAASDPMWRDIVALNAPAIAEALS-----DYQQQLQTYANLLEQQD. 266
240 6.000e-52UniRef50_A0A1G1I305 Uncharacterized protein (Fragment) n=1 Tax=Nitrospirae bacterium RBG_16_64_22 TaxID=1801708 RepID=A0A1G1I305_9BACT  ali  14  1............................................................................................GGSLARAM-KDRGLVDEVVGVGRGEANLKRAVEMGVEFTHDPAEGVRGATLVVLATPVGTFEP-IAREIRPHLQAEAIVTDVGSVKGGVVHALEDLLEGSAA-------FVGSHPIAGGEKSGVELTPTPRTRGFAIDRVEALWQAVGCRTVRLDPDVHDKIFAAVSHLPHAVAFALVAAVERMDGGLD-LRNFSG----GGYRDATRIGASPAVWRDIFLLNREHTAAALR-----VFEEEIAAIRREIEEGR. 251
241 6.000e-52UniRef50_D9QPW5 Prephenate dehydrogenase n=2 Tax=Halobacteroidaceae TaxID=53434 RepID=D9QPW5_ACEAZ  ali  13  5.................................................................................DRIAIIGVGLLGASLGLACKRFTSVT-EIVGYDQNKDHLKEALEIGIDGIIDNLELLGEVDLVVLATPIS-VIPDILNKIQKQVRPGTIITDVGSTKGWLMEKINNQL-------RSDITYIPGHPMTGSEVSGPVYVLTPLTPEDRQQALVELLEEIGAKLLFMSPAEHDRIVAAVSHLPHVMACTLVEAVGQAARDDDHVFSLA----AGGFKDTTRIAASPRMWTDICLSNSEEILEMIRTF-----KGELAEFERVLAANK. 269
242 6.000e-52UniRef50_A0A1F5DN79 Uncharacterized protein n=1 Tax=Candidatus Bathyarchaeota archaeon RBG_13_52_12 TaxID=1797379 RepID=A0A1F5DN79_9ARCH  ali  16  13.......................................................GAGVMGHGIAQIAAQAGISVTVRDIEQSFLDGAKAGINKNLGRLVERGRLKQEDLPTII-GKINM----------TLSLPDAVKDADVVIEAVPEMEVKHAVWSEVAQHTRLDAILTNTSSLSITEMATVVSDPG-------RFVGMHFFNPPTI--MKLVEIIPGDKTRSETIATIKGLAERLGKTPVVVRRDAPGFIVNRILITYLNEAAKLLEVDAAMQFKVGMPMGPFMLADLIGLDITYNIL............................................. 248
243 6.000e-52UniRef50_A6TL03 Prephenate dehydrogenase n=5 Tax=Terrabacteria group TaxID=1783272 RepID=A6TL03_ALKMQ  ali  11  2..............................................................................IPFQRVVIIGMGLIGGSIALALRKA-GYEGEIIGCDSSRQSLEEAEAIGAQGYQDLGEGVKEVDLVILAVPLGYY-RQVLKEIAESLPKDVVVTDVGSVKGCVEEIISQELS-------QSIQFVGGHPMTGSEKGGFHLTPNPYTKEETIEGLKDFVKLLGAFPVVVETKQHDEIVALISHIPHLAAVLLANML-----DRKNSISYI-PFVGGGFRDTTRIAAGNPMWQDIFFYNKKEILEMLQEFKVLLQDDESEEVLENLQRAK. 277
244 7.000e-52UniRef50_A0A2N2PI69 Uncharacterized protein n=1 Tax=candidate division BRC1 bacterium HGW-BRC1-1 TaxID=2013722 RepID=A0A2N2PI69_9BACT  ali  11  6................................................................................FPQITIVGPGLLGSSLG-LAARERGLCEKIVGVGRNQTSLDDALRVVDTTTTDLEAGLAEADLVVLCMPICTIV-QMLPQIMAACKAGALVTDVGSTKCSIVKTGQK------FSKPNGAQFVGCHPMAGSEKFGARVTKTDATDLKAFAQVSALWRALGTRLVVMRPDRHDGLAAMVSHLPHMIAVSMMKAMELSGEDKNLVRGIIGN----GFRDMTRVAAANHMWVDIGCDNQAAVREALSLFKEALNEDKLRGFLEDAAEYRD 286
245 7.000e-52UniRef50_A0A2E4MYN3 Prephenate dehydrogenase n=11 Tax=Gemmatimonadetes TaxID=219685 RepID=A0A2E4MYN3_9BACT  ali  15  5.............................................................................DFTDTSVAIVGVGLIGGSLS-LAFKRAGIRTRIIGISR-RETLDRAVEQGAIDEDDIAEGVAKADLTILCTPITRI-LEMIPACLAAAKSGSIVTDVGSTKRAVVEAA-------SRQGRSDVFFIGGHPMAGSEWKGVIYVLTPSNDSERLGWLAGLTEQIGAHVVQMDPDTHDRVAAAISHLPQIMATTLVGMVGRMNQKDGLPLK----MAAGGFRDMTRIASSPEMWRDICRTNADPIREAMEELKGRIETDSLEADFDYANEVRD 285
246 7.000e-52UniRef50_A0A1Y4UR89 Uncharacterized protein n=1 Tax=Tyzzerella sp. An114 TaxID=1965545 RepID=A0A1Y4UR89_9FIRM  ali  13  22.....................................................................................................RNRCGVKEIVACNRNIDVLEMAQSEGVAYSTDVTDIFCGCDIVIICTPVGKIF-EYAEKLTKYIDKDCIITDVGSTKLTIYENMKKIADK--------ITYIGGHPMTGSERENAYYILTPNVSDEKVLKLKSMVEKIGAIPVIISPKEHDYVTASISHVPHVLAAGLVNTVK----NLDSEKGYMHLLAAGGFRDTTRIASSSPMWESICLENRDNIIDVLTSFEEVIKNGDSNEIHSFFENAK. 276
247 7.000e-52UniRef50_UPI0006D5000B hydroxyacyl-coenzyme A dehydrogenase, mitochondrial-like n=1 Tax=Halyomorpha halys TaxID=286706 RepID=UPI0006D5000B  ali  14  3.............................HTARFSSAAFVGIKHVTVIGG-------GQMGSGIAQVIAQKGQNVSLIDVSEEALKKSKETITKSLKKVAKRYKEKTEEADKFVENSLRQ-------IEFTTDLLGVASQSDLVLEAIAEDKLKREVFASIDKVAPERTIFTNTSSIPVRDISAAVERKD-------RFTGVHFFNP--VPVMQLVELVRTDTVSDATYNTLMEWVKSIDRKPISC-KDTPGFIVNRLLFPFLSEAIKMYEIDLAMKLGLKHPMGPIELADWIGHDT---IASSNAVWRDLHPGNP--VFAPLKSQLKLVEEGKL............ 290
248 7.000e-52UniRef50_W7QEP4 Bifunctional chorismate mutase/prephenate dehydrogenase n=4 Tax=Alteromonadaceae TaxID=72275 RepID=W7QEP4_9ALTE  ali  11  47.......................................................................................................KRIVVVGGRGKLGSLFVRLFTELGHSVSNNAQQIVEHADLVVVSVPIN-LTSSVIKQLVGYLSAETILADLTSVKAQPLADMLEYHAGP---------VVGLHPMFGPDVPDQVVAYCDGRTPQQYQWLLDSLALLGAKLTKVTAESHDKSMAFIQVMRHFSTFVYGLHLQQENPKITDLISLSSPIYRLELAMVGRLFAQDQLYADIIYSNPANF------QLLKRFAERFNEGIQLLESGDK 285
249 8.000e-52UniRef50_A0A2E7CX39 Prephenate dehydrogenase n=5 Tax=Planctomycetaceae TaxID=126 RepID=A0A2E7CX39_9PLAN  ali  14  28.................................................................................................AAAAKKRVLAQRIIGIGRNAERLQRASDGGLSYSTELSQAAEECDVLVFCTPVNRIIEGV-RTAAASCRSGTLITDVGSCKAGICQSLSAEL-------PSNVSFVGSHPIAGSEKQGFECVVTPTARDAQLSRTTRFWQALGATVIQMSPEAHDLALAETSHLPHVVAAALSRALDSENRQL----------AATGFRDTTRIAAGDPLWLAILQDNRDAVLEQLDSFQESLQNRDVEGLKKLLEDAK. 286
250 8.000e-52UniRef50_C0ZCE8 Prephenate dehydrogenase n=41 Tax=Bacillales TaxID=1385 RepID=C0ZCE8_BREBN  ali  13  10.......................................................................................GVGLIGGSIALSMRRDPNI--RVVGYDLRQDCLDKALTLGVAGTTDLQTAVREANVIFLASPVEQIVPTIRSLVEMELQPGVIITDVGSTKAGIVTQAADVI-------PDHVTFIGGHPMAGSHKSGVELTPAPGTSVEKVKQLSELLTLTRAKVVQMDAASHDQVVGAVSHFPHILASALVNLVA----GYDEENAWHTTLAAGGFRDITRIASSNPMWRDILLQNRDPILKALEDVVHLVEQGDPEGIEHFFKTARE 279
251 8.000e-52UniRef50_Q1IDA0 3-phosphoshikimate 1-carboxyvinyltransferase n=194 Tax=Gammaproteobacteria TaxID=1236 RepID=Q1IDA0_PSEE4  ali  13  15..................................................................................RLVVVGLGLIGGSFAKGL-RESGLCREVVGVDLDAESRKQAVALGVRCEEDLAAACVGADVIQLAVPILAM-EKLLARLAQLDLGDAVITDVGSAKGNVVRAARESFAERLPR------FVPGHPIAGSEQSGVEVILTPLTDPQALALVDRLWRALDADVEHMSVERHDEVLAATSHLPHLLAFGLVDSLAKRNENL-EIFRYA----AGGFRDFTRIAGSDPMWHDIFLANREAVLRTLDTFRS-----DLDALRDAVDAGD. 276
252 8.000e-52UniRef50_A0A2H6A6L3 Putative 3-hydroxybutyryl-CoA dehydrogenase n=186 Tax=root TaxID=1 RepID=A0A2H6A6L3_9BACT  ali  13  5.......................................................GAGTMGSGIAQVFAQRGWRVVLVDAVAEQLERALGSIRRNLDRQVERGKLAAGE-------RDAVLRAIEKG-----TGLESARDCSLVVEAVVEDRVKFEVFSRLGELVKDDAILTNTSSISVTEIAAHASRPE-------RVVGMHFMNP--VPVMQLVEVVRGLKTSDGTVNRVKEIAVELGKTPVEVN-DYPGFVSNRVLMPMINEAIYCVMEGVAMKLGMNHPMGPLALADLIGLDVCLAILEVLHRDLGDDKYRPCPLLRKMVAAGRLGRK............... 269
253 8.000e-52UniRef50_A0A2E4ZUW5 Uncharacterized protein n=3 Tax=Opitutae TaxID=414999 RepID=A0A2E4ZUW5_9BACT  ali  11  1...............................................................................MFEKITIVGPGLLGASLG-MAIHARKLARTASIWARREESRKACLATCQEVSGDLEEALRKAELAVLCTPVVHLT-EMLGEIGSFLSPDCLVTDVGSTKANICQAASEA---------KLTSFVGSHPIAGSEKTGLEVTQIENNDSAHSEKVADFWQALEMKVIRSTPEEHDQILAHVSHLPHLLVSTLCHALGNRPKE-------WSNGCGQGLRDTTRIAASPAIWTDIAQQNREEILKALDSLRILLEENDSEKLFRWLDKSK. 272
254 1.000e-51UniRef50_A0A2H6A1C2 3-hydroxybutyryl-CoA dehydrogenase n=189 Tax=Bacteria TaxID=2 RepID=A0A2H6A1C2_9BACT  ali  12  2..................................................AEIKTVGGLMGSGIAQVCAQAGYRTIVREVSDALNQKGKANIIASLDKLVQKGK-----LDGGTREQI------LNRLQFTTDLKELAP-CDLVIEAVTEDELKNSLWKELDGLCGPQTIFANTSSLTIAAMAAVTSR-------GDRFVGLHFFNP--VPVMKLVEVVRTVTTSQATFEQAMAFARSLGKEPI-AAKDSSGFIVNLLLVPYLLDAIRALERGVGSVEDIDHPMGPFTLLDFVGLDTTYKIAEIMFNEYREARYAPPPLLRRMVLTGMYGRK............... 275
255 1.000e-51UniRef50_A0A2E8C2B9 Bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase (Fragment) n=23 Tax=Gammaproteobacteria TaxID=  ali  15  9.......................................................................................GLGLIGGSFAK-GMRESGLCREVIGCDLDPVARRQAVPLGVSTTADLAEAVRGADLIMLAVPVLGM-RAVLAQLAAMDLGQAVMTDVGSTKGAVALAVEEVFGRVP------ANFVPGHPIAGSEKSGVEVILTPLTAKQAVALVQSCWQALGADVEQMSLADHDEVLAATSHLPHLLAFSLVDTLASRNENL-EIFRYA----AGGFRDFTRIAASDPMWRDVFLANRDAVLRSLDAF-----TQDLGRLREAVETRD. 265
256 1.000e-51UniRef50_A0A1V6DAU6 T-protein n=1 Tax=Planctomycetes bacterium ADurb.Bin126 TaxID=1852903 RepID=A0A1V6DAU6_9BACT  ali  14  15............................................................................MRDKLRHVTVIGVGLLGGS-AALALKACDPSVRIAGVGRRRESLQMALDAGAIDTADPAPAVVQSDLVILATPVGAFARH-LREIAPHLRRGAAVTDVGSTKSAVVRQAERLLGAGGP-------FVGSHPMAGSEQKGVTCIVTPRTPPRLVRRIERFWQLLGTRTVRMGPAEHDRAVAAISHLPHVLASLLMLL----------PDSHSLQVAATGFRDATRLAGGDPMWRDILLTNRRAILGALDRFD-----ERLMHLRDLLEMGD. 276
257 1.000e-51UniRef50_V6DSX9 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein n=54 Tax=Halobacteria TaxID=183963 RepID=V6DSX9_9EURY  ali  13  13.......................................................GAGNMGHGIAEVAALAGYDVSLRDINDELVQKGYDQIEWSLGKLAEKDRIGDDE-----------ADAALDRVDAFVDLGDALDGADVVVEVVPEMSIKKDVYDEVVEHAPDEAVVTNTSSLSITELSEVTDRPE-------RFCGMHFFNPPV--RMDLVEVISGKHTSEETLELIEGLAESMGKTPVRVRKDSPGFIVNRILVPLMNEAAWVVESGDATKFGMGLPMGSFELADQVGIDVGFHVLEYMH-EVLGDAYRPCPLLAEKVEAETLGKK............... 278
258 1.000e-51UniRef50_A0A2C6MDP7 Prephenate dehydrogenase n=1 Tax=Desulfotomaculum profundi TaxID=1383067 RepID=A0A2C6MDP7_9FIRM  ali  13  1...............................................................................MFKKVVIAGVGLIGGSLGLALSK-RKLAAEVVGVDPNRENLRLAVQVGVQRTETLAEAVPGADLLILATPIG-VTLGVLEMAVPYLTPGTVITDVGSVKGQLVDRAEAML-------PAGVHFVGGHPMAGREVTGVILTTTQSTNAAACVRLKRFIQALGAHPVELGCREHDRAVALISHLPHLLAATLVITVAGEP-----AQELLLKLAGGGFRDTTRIAAANPMWRDILLTNREMVLEAVCKFRRQLEQINQEELVSSLEQAKQ 276
259 1.000e-51UniRef50_A0A1F2WTH9 Uncharacterized protein n=1 Tax=Actinobacteria bacterium RBG_13_55_18 TaxID=1797197 RepID=A0A1F2WTH9_9ACTN  ali  12  32..........................................................................................................VDQVLGYDSDPAMLEQARAGGAKASNDIADLSSACDLIFIAVPVRSI-EKVMAEVAPNLKPGTTVSDVGSVKERVVKAASEIL-------PPGTSFIGGHPLAGSEQRGVELTPGPGCGDEAYSRLHALLTSLGARVIAMDPLQHDRAVSVISHLPHIMAMSLMNLALERAEEY-----PLLRLAAGGFRDMTRIAASSPIWLDILLENRDAILRSIGRMLEQSDENALEGWMETASRGRQ 285
260 1.000e-51UniRef50_A0A2D4XC73 3-hydroxybutyryl-CoA dehydrogenase n=22 Tax=cellular organisms TaxID=131567 RepID=A0A2D4XC73_9EURY  ali  13  27.......................................................GAGTMGSGIAQVCAQTGWETSLFDAFPESLERGMGNIGDFWDR-------------GISKGKTTLRQKEEANLIATSEMSEAVRDSDIVIEAVPEMDLKRSIFEELEDLAPQNAILTNTSGLPISEIAANTGCPE-------RVIGMHFFNP--VPLMQLLEIVRHDEVDEHTLSIAKEVGEAMGKTTILVR-DVPGFATSRLGVVLGNEAIRMLAEGVASASDIDHPMGPLELSDLIGLDVRRDILNSLAEAFEDDSYRPHPLLEELVDSGNLGKK............... 292
261 1.000e-51UniRef50_A0A2E8B1J7 Prephenate dehydrogenase n=2 Tax=Planctomycetaceae bacterium TaxID=2026779 RepID=A0A2E8B1J7_9PLAN  ali  13  21.................................................................................DTVTIVGVGLIGGSVGLALRK-RGLARNVVGVGRNQSKLRKAQRQGAITTQDVEHGVSDADVVVICTPVESIGP-FAERAARACPAGSLVTDAGSTKSNIVASVR-------PKWPREVGFVGSHPLAGSEKSGCEVTPTAKTSEKHLKKAVQFWNSLGSVVIQMSPKQHDQAIAMTSHLPHVVASILAASAGKDHL----------PLAASGWLDTTRIASGNDLWKQILTDNQPQVLKAIDKF-----EKTLHSFRRALQSGRR 278
262 1.000e-51UniRef50_A0A1Y3PPC2 Uncharacterized protein n=5 Tax=Bacillaceae TaxID=186817 RepID=A0A1Y3PPC2_9BACI  ali  16  14.......................................................GAGDMGHGIAEVALLAGYRVHLYDIKQEYLDRGVKRIHDSLAKLAEKGKI----------DADTHERSRQL-LHPTTDLSEAVSAAQFVIEAVPVLKIKQEVFQKLDQLAPETAILTNTSNMSISDIASVTRRPE-------RVVGVHFFNPVVL--MKLVEVIRGEKTTEETMQTACEVCRKLGKEPIRVEKDVPSFIVNRINAPIRVFLGAVVDAGEATPEDAGEPMGPFELLDYVGLDITY-----DSMDYRRQVLDPEALEKLVKAGHLGKKTGQ............. 281
263 1.000e-51UniRef50_A0A1C7P9C5 Prephenate dehydrogenase n=2 Tax=Akkermansia TaxID=239934 RepID=A0A1C7P9C5_9BACT  ali  16  38................................................................................................................WARREATLQQALDMGIAACTDPTEAVRGADLVVLATPIGAF-RDLAEQIAPSLAPGAIVTDVGSVKNYV------HRTTGAWLHEQGHTFIGSHPMAGSEKQGLEIVLTHAAPEHTVDRLRQFWELLGGRCYLMESKHHDRTVARISHMPHVLAA--LCAYSATRGDVR--MHDLQSLAATGFRDTTRVCSSPSMWTDILWENDCAILDDLTELIRLLEIQDKETLHTWLEQARD 284
264 1.000e-51UniRef50_I2C7J2 3-hydroxybutyryl-CoA dehydrogenase n=1004 Tax=root TaxID=1 RepID=I2C7J2_BACAM  ali  14  1..............................................MKMKTIMVAGAGQMGAGIAQTAAEAGFAVKLYDWEPETVKKGLHRIKANLEKEQAKGRKSQQETDAVF-SRISPAELTEAG------------DADFVIEAIAENKAKAELFDTLDKICPSHAVLANTSSLPITELAAATKRPE-------KVIGMHFMNP--VPVMELVEVIRGLATSEETAETVKKLAVRMNKTPVEVN-DFPGFISNRILMPMINEAVYCLYEGAASKEAIDHPMGPLTLADFIGLDTCLSIMEVLYAGLGDPKYRPCPLLRKYVSAGWLGKK............... 273
265 1.000e-51UniRef50_G2LDZ1 3-hydroxyacyl-CoA dehydrogenase n=29 Tax=Bacteria TaxID=2 RepID=G2LDZ1_CHLTF  ali  13  1................................................MGTFAVIGAGTMGSGIAQVAARAGFQVVLRDVAPEYLDRGLATIRSSLER-------------DVKKERLTVAQLEEARIRPTTELAE-VAGAEIVVEAIIENEAKAALFRELDALTPPETVLTNTSSISITRIAATTKRPA-------QVIGMHFMNP--VPVMPLVEVIRGCATSESTANYVLELGARLGKTCL-MANDFPGFVSNRILMPMLNEAFALYEIDGIMKLGMNHPMGPLTLADFIGLDVCLAILDVLYEGFGDPKYRACPLLRQYVAAGWLGRK............... 272
266 2.000e-51UniRef50_A0A1Y1SGF8 Prephenate dehydrogenase n=1 Tax=Oceanococcus atlanticus TaxID=1317117 RepID=A0A1Y1SGF8_9GAMM  ali  14  8.......................................................................................GIGLIGGSLAAGL-RTVGQVERVTACARRQETLDTARQLIDDGSTDLASAIAGADMVVLAVPMGAY-REVFSALKPIWPEHAVVTDAGSSKLSVIEDARAVFGHVPS------NFVPGHPVAGTEKSGPRVILTPQTSAAALQAVRAMWESVGAQVHVMSAQHHDEVLALTSHLPHVIAYQLIETLARL-DDQREIFSFA----AGGLKDLTRIASSNPMWTDIMMANDTAVLEGLDR-----YIEDLQALRELLAAGD. 264
267 2.000e-51UniRef50_A0A2E7QNP9 Prephenate dehydrogenase n=3 Tax=Bacteria TaxID=2 RepID=A0A2E7QNP9_9BACT  ali  14  78.......................................................................................GMGLLGGSVG-LAIKAHGVSGHVCGLVRREESIAECLNVGAEATLDPQAALADATLVILCTPVGQMA-DMTRQLKPHLSPGTILTDVGSVKADVVATVEPIWPR----------FVGSHPLAGSEKTGVTVTPTEQSDPAVVEAVEKFWQSLGSRTLRLSPEAHDSVVARTSHLPHVLATALVRTVLGGAKN-------GEPDFATGFRDTTRLADGSAMWRDIALANPDAIADA......................... 310
268 2.000e-51UniRef50_A0A2A5EHW7 Prephenate dehydrogenase n=3 Tax=Zetaproteobacteria bacterium TaxID=2026807 RepID=A0A2A5EHW7_9PROT  ali  14  6.................................................................................QHLVIIGTGLIGGSLA-LALKQAGVVKRITGVGRSPQNLHDAIRLGVDASDNIQQAVQDADMVLLAVPVAACA-QVFKDIADALPEHAIITDAGSTKQSVIKDAQKSGLDMSR-------FVPAHPIAGTEHSGHRCILTPETSAESLAKVREMWKYTGANIEIMDAKQHDDIMASISHLPHLTAFSLINALHD-----DDVFRFA----AGGFRDFTRIASSPEMWRDIALCN................................ 237
269 2.000e-51UniRef50_A0A1T4VPE5 Chorismate mutase n=2 Tax=Succinivibrio dextrinosolvens TaxID=83771 RepID=A0A1T4VPE5_9GAMM  ali  12  71...........................................................................LLSDVMKRLLRESYKDTDFSYPKTLSEDGDIVIVGGNGGMGRIFSRYFEASGYRVFSKAPQYLKNAKVVIVTVPI-DVTVDVIKQLSPLLREDQILCDFTSVKAPIVDAMMKYHKGP---------VLGLHPMFGPDIKKQVIVTVPERDEKASEFLVEQFRIWGAKIFKSGAQDHDRAMSIIQALRHFGTYSYGSFLKNLNPNLKRLIDLSSPIYRMELMMVGRLFAQDPLYADIIMANVDLIRNFVKSLADDLKIKNVDAFTENFIKIRE 352
270 2.000e-51UniRef50_D4M6F1 3-hydroxyacyl-CoA dehydrogenase n=41 Tax=Firmicutes TaxID=1239 RepID=D4M6F1_9FIRM  ali  15  10.......................................................GAGLMGNGIAQACATAGYDVVNIDTFEAAIEKSKATVEKLFSR-------------KVAKGSMTEEKAEILGRLTYSQNFEDVKGAFLVVEAVPEKEIKKDTFKKVDELADAETIVSNTSGLSISEIASVTNRPD-------KVMGAHFFYPA--PVMKLLELVRGLVTSDETYDVVKEFAGKIGKTTVDA-PEFPGFMVNRILVPMQNEAAFMVDVDNAMKLGCNHPMGPIELTDFVGIDTMLATMTGLYNGFHDSKYRPCPLLETMVKSGMLGK-KTGQGFYKYDEKGNK 287
271 2.000e-51UniRef50_D5DJX4 Prephenate dehydrogenase n=104 Tax=Bacillaceae TaxID=186817 RepID=D5DJX4_BACMD  ali  13  1...............................................................................MKENVFVIGLGLIGGSLALNIKKTHH-HLDVIGFDINQEQLELAKTLGVQAASSLQQGAEQADYIVIAIPVTQAA-EVLKQLEHFLKQSVVVTDVGSTKEEVVKTAEALIA-------KGIEFIGGHPMAGSHKSGVAYVLTPSTSSEALGSLKELLSGTKAKIIVMSPKEHDKLAGVISHFPHIIAASLVHQAEYYQQD----NQLVSQLAAGGFRDITRIASSSPMWRDILLHNQDALLSMFDHWLEMIERKDANDIYTYFSQAKQ 279
272 2.000e-51UniRef50_A0A1Z7YWF5 3-phosphoshikimate 1-carboxyvinyltransferase n=1 Tax=Gammaproteobacteria bacterium 42_54_T18 TaxID=1856293 RepID=A0A1Z7YWF5_9GAMM  ali  16  15..................................................................................RVVIVGLGLIGGSFACALKKA-GVVKHIIGCARSEETLKLGLAMGVEAQTDVAEAVKGADLVMLAAPIG-LTEMLLEKMKPGLDGKTIVTDAGSVKGNVIAAVEKVFDGLPSW------FVAGHPIAGSERSGVKVILTPTKSAQAVSIVTKAWQVTGAEVLEMEVERHDEVLAATSHLPHLLAFSLVDTLAKEDEN-QAIFRYA----AGGFRDFTRIASSDAMWHDIFIANKSAISTMLDHFEHG-----LKTLREAVDSQD. 276
273 2.000e-51UniRef50_A0A0F7M754 Prephenate dehydrogenase n=24 Tax=Proteobacteria TaxID=1224 RepID=A0A0F7M754_9GAMM  ali  13  9.......................................................................................GLGLMGGSLAAAL-KAQGMVNTVVATGRRSGSLQRGVELGVEYTLDLAAAVRGADMVVIATP-TQVAEAVLESLAPLMTADMIVTDVASVKGNMQQAAERIFGEVP------ANLVLAHPIAGSEQSGVRVILTPLTDVDAVSKVRAMWRACGAEVLCMSVSDHDAVLASTSHLPHVLAYTLVDALAKDGR-AGEIFKFA----AGGFRDFTRIASSDPMWHDIVLANRDAVLAGIDELRSAIEQGDGAKIYTVFDQAKK 278
274 2.000e-51UniRef50_A0A1G9WFQ3 3-hydroxyacyl-CoA dehydrogenase /Enoyl-CoA hydratase n=4 Tax=Halobacteria TaxID=183963 RepID=A0A1G9WFQ3_9EURY  ali  11  13.......................................................GAGNMGHGIAEVASLAGYDVNMRDIKDEFVQGGYDKIEWSLGKLADSE-------------QISEDEADAALDRVTVDLEETVADADVVIEAVPEMDIKEDTWTDVEEYAPEHTVFTNTSSLSITDLSEFTDRPE-------RFCGMHFFNPP--IRMDLVEVISGEHTDDATLDIVEDLADDFGKTPVRVRKDVPGFIVNRVLVPLMNEAAWLVDEGVATKFDIGLPMGSFELSDYVGIDVGYHVLDYMHEVAGERYEPAPMMVEKVENEEFGQKTGQ............. 281
275 2.000e-51UniRef50_U2ELA0 Prephenate dehydrogenase protein n=2 Tax=Gammaproteobacteria TaxID=1236 RepID=U2ELA0_9GAMM  ali  13  23............................................................................................GSIVRALRSKGFRGTIDAVVADDDEARQARELRLVDEPFTDIAEAVAKATLVVVAVPIGSMA-SVFASMADALPADAVVTDTGSTKLSVIREAQTHFGDRIGR------FVPGHPISGTERSGVILTPTPETDRDALSRVVALWRAVGAQVSEMDGAHHDEVLAATSHLPHLLAYTLVDTLARMAERT-EIFEYA----AGGFADFTRIASSSPLWGDIVTANHDAILPVLDR-----YIGDLEAVRAAIADGDR 274
276 3.000e-51UniRef50_A0A2D7PER3 Cyclohexadienyl dehydrogenase n=1 Tax=Candidatus Pelagibacter sp. TaxID=2024849 RepID=A0A2D7PER3_9PROT  ali  12  20..................................................................................................IREKNNDVIINIVDNSNTVLEKSKKLNLGNNYFEEISTFIDKTEIIFICTPISAY-RSLFEKLNKFLSDETIITDVGSCKTEVIKNAQNILT-------KNIKFVPAHPIAGTEQSGPEITPCKNSDDKSVKIISNLWKSFGCKIQIMDMNDHDSIMAITSHIPHIIAYNIVGTASELEDNLEEVIKYS----ASGFRDFTRIASSDPMWRDIILSNKEPILKMLEKFKNAIVNDDKEKLFNIFDKTRD 279
277 3.000e-51UniRef50_A0A1Q7W1M2 3-hydroxybutyryl-CoA dehydrogenase n=9 Tax=Actinobacteria TaxID=201174 RepID=A0A1Q7W1M2_9ACTN  ali  14  9.......................................................GAGLMGSGIAQVAAAAGYDVAVRDVTDAALKRGTDGIRASLEKFAARGRYSGDEV-----------EAALGRLSTTTDLAEAVDGADVVVEAVFENEVKQEIFRELDRLAKPGAVLTNTSAIPITQIAAVTSRP-------RDVVGTHFFSP--VPMMQLCELVRGYKTSDETLAKARAFAEEVGKTCIVVNRDVAGFVTTR-----------LEDIDLACRLGFGHAMGPLATTDLTGVDILRNATRNIYTETQDEKFSPPELLNRMVTAVDLGRQ............... 256
278 3.000e-51UniRef50_A0A1Q3FGZ7 Putative 3-hydroxyacyl-coa dehydrogenase lipid metabolism n=26 Tax=root TaxID=1 RepID=A0A1Q3FGZ7_CULTA  ali  15  8....................................................VVVGAGTMGSGIALVSAATGHVTTLVDLNAQVLEKARGEIEKNAARLARKFFK-------EDPAAASAMVAETLGIKYCAELEEAVRDSDLVIEAIVENKIKQDLFRRIDGIAPQHTIVSNTSSLSIVELGSVTQRQD-------RFAGFHFFNP--VPLMKLVEVIKTDRTSAETNASSLAFGEALGKTCISC-KDTPGFIVNRLLGMLERGDASMRDIDTALKLGLGHPMGPFELMDMIGLDVTLNIM............................................. 251
279 3.000e-51UniRef50_D7AVD9 3-hydroxybutyryl-CoA dehydrogenase n=16 Tax=Actinobacteria TaxID=201174 RepID=D7AVD9_NOCDD  ali  14  14.........................................................GAMGAGIAEVFARAGFNVTGVEIDQAAVDRGRAHVDRSLSKA-------------VDKGKLTEDERTGIDARLTTTSREDLADADFVVEAVPEMDIKKDVFADLDRICPPGTILTNTSSLSVTEIAALTGRAD-------KVVGLHFFNPA--PVMKLVEVITTVSTSAETVDVVCEVAKRIGKTPVAVG-DRAGFVANALLVPYINDAIRLYERKVATREEIDAPMGPLALADLVGLDICLAVMDVWEEYRD-RRYAASPLLRRMVAAGRLGRK............... 276
280 3.000e-51UniRef50_A0A2N2D9C2 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Firmicutes bacterium HGW-Firmicutes-13 TaxID=2013774 RepI  ali  13  13.......................................................................................GVGLMGGSLG-MALRNRRLTEKVTGIFRNEEKIKAAQRLGAAGTTEFKEGLRGAELVVIGTPVGTSIK-VIEEIIPFLEPGCIITDLGSTK-------LELTEAAERLLPPDIYFVGGHPMTGSEESGVELTAGENTNPGALQAVKLMVEEIGAQSLIMDPEEHDLVVAAVSHLPHLTAVTLVNTIPDIGVDINKALVLA----AGGFRDTTRVASSPHMWKDICLSNRKMIFKT......................... 250
281 3.000e-51UniRef50_F4P0M5 Uncharacterized protein n=10 Tax=Eukaryota TaxID=2759 RepID=F4P0M5_BATDJ  ali  14  48.......................................................GAGLMGSGIAQTAAQFGFKVNLIDSSNDALARSRKNIESNLVRESKKQHGSA-----VASAQIFVNNTMELLTH-STDLTAAAKSSDLLIEAIVEMDAKRKLFTQLDLIAPKHAIFANTSSLPIAEIAKATSRPG-------QFAGLHFFNP--VPVMKLVEIVRTKDTTEETCKSLALFTDQLLKKAV-MCKDTPGFIVNRLLVPYLLEATRIVERGEASKEDVDYPMGPFELMDYVGLDTIKFISDGWYSDSDVLKGNPSQLINGLVAQQKFGKK............... 322
282 3.000e-51UniRef50_D5EMR4 Prephenate dehydrogenase n=8 Tax=Opitutae TaxID=414999 RepID=D5EMR4_CORAD  ali  13  1...............................................................................MFHQITILGPGLLGASLA-MAAKERTLTQRIVTWSRREETRSKCMQRDDAVCSTASEAVRGSDLIIICTPVHTIVP-LLKEIATSLEPGAIVTDVGSTKQVICETAQ-------GVVPPPSHFIGSHPMAGSEQTGMEFILTPMEDTDASDRLGQFWQALGMRLTTVSPRQHDEIVAHVSHLPHLLASNLCCYLDNKDSAWQELSG-------GGLRDSTRVASGDPLWRQILEQNRDEVLNELQSFKQALVNQDGPSIQSFLERGK. 274
283 3.000e-51UniRef50_A0A1I2MP28 3-phosphoshikimate 1-carboxyvinyltransferase n=3 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A1I2MP28_9GAMM  ali  14  32............................................................................................................IVAGYDRNPDDLQQGLDLGIEGFSDLAEVVATADIVVLAVPVKA-TENVLAAIKPYLSPATVITDVGSTKANVILAAQTVFGTVPDK------FIPGHPIAGSEKSGVKIILTPLSDESATRLIARMWQSTGAEVLQMGVERHDEVLAATSHLPHILAFSLVDTLAKE-QDSREIFRYA----AGGFRDFTRIAASDPMWHDVCVANKQEILNQIDNFTDG.................. 256
284 4.000e-51UniRef50_A0A0H4KM73 Prephenate dehydrogenase n=9 Tax=Bacillales TaxID=1385 RepID=A0A0H4KM73_9BACI  ali  14  1...............................................................................MTRNIAVIGLGLIGGSLSNIRETQENVHMIGYDINKDQLHLAKSLGVIDEEASSIECACEKADIIIIAVPVTH-AVALCEKLASLLKKGVIITDVGSTKTKIVETA-------NIFAHQDVHFIGGHPMAGSHKSGVAYILTPHTAEEKVSELKQLLQGTKSQLIEMTPSEHDRVAGVISHFPHIIAASLVHQAKKYKKQ----NELTSKLAAGGFRDITRIASSSPMWRDILIHNQQSMLEEMEEIKEMVRSLDAEGIFNYFEEAK. 278
285 4.000e-51UniRef50_A0A1C0ZXJ7 Prephenate dehydrogenase n=8 Tax=Bacillales TaxID=1385 RepID=A0A1C0ZXJ7_9BACL  ali  14  8.......................................................................................GVGLIGGSLALCFKGKPDFTVVGHSPNPNSVQKLLKRNVVDHATTDMAEAVDGADYIFLCVPVGNL-EEYVQQLMKLLKQGCIITDVGSTKASITESAAAHL-------KEGYYFIGGHPMAGSERHGVEYVLTPGTPQAQVDRLTALLSLTKAQIVQVDAREHDDIVGAISHLPHIIAVALVNQVR----GYNECNPLYQNLAAGGFRDITRIASSEPIWRDILVNNREVLLKLLKDW-----NGEIARFIQMLE.... 261
286 4.000e-51UniRef50_A0A2E9VJE0 Prephenate dehydrogenase n=1 Tax=Rubinisphaera sp. TaxID=2024857 RepID=A0A2E9VJE0_9PLAN  ali  13  13.................................................................................QTLAIRGVGLIGGSIAKAARKAR-IVQEIIGIGRDEARLQKAVEIIDRFETDSKLAASQADLIVVCTPVDCIAQDII-QLHSGLRPEALITDAGSVKEQIVREVAEKLGAGHR-------YLGSHPLAGSEKTGFEVVLTPESSKNDLKFLETFWKSLGGKITIMSPAEHDRALAATSHLPHLIAAALASSVPEDQL----------PLAATGFGDTTRIASGDPLWTSIFCQNSNGTLAAAKEF-----QQQLNALLDAVEAKD. 269
287 4.000e-51UniRef50_A0A2D8HZ42 Uncharacterized protein n=1 Tax=Opitutae bacterium TaxID=2026771 RepID=A0A2D8HZ42_9BACT  ali  12  1...............................................................................MFNQITIIGIGLLGASLGMAVKK-HKISKYIKVWARKETTLEKCKEWCDECESNLDRAVTGSEFVVVCTPVESI-PDILEKISPFLANGCIVTDVGSVKGKICDSAVKIFENSPGY------FVGSHPMAGSEKSGLEYAYCVVTSDEVLKRTIKFWDRLLMKTVPFTPAEHDLAVSYCSHLPHLVASCLAKSLKDKEKK-------WLQIAGNGLRDTTRIAGSPDLWKQIILMNKDNIIGSIEEFEKVINKGNSDQLISILEQG.. 274
288 4.000e-51UniRef50_A0A1V5DQE2 Putative 3-hydroxybutyryl-CoA dehydrogenase n=31 Tax=cellular organisms TaxID=131567 RepID=A0A1V5DQE2_9DELT  ali  17  10.......................................................GAGQMGNGIAQVAAHGGLNVIMNDIAEQFVDKGIDTISRNLDRLVAK-----------DKLKAEQKKEILSRIKPSTKLEDM-KDADFVVEAAVERDLKLNIFRKLDEICKPGVILTNTSSIPITKIAGATRRAQLV-------IGMHFMNP--VPVMKLVEIIRGLATSQETYNLTEALSKQFGKVPVECN-DFPGFVSNRILMPMINEAYALFEIDDIMMLGMNHPMGPLALADLIGLDTCYAIMDVLHKGFGDSKYRPCPLLKKYVDAGFLGRK............... 275
289 4.000e-51UniRef50_A0A0R2V886 Prephenate dehydrogenase n=3 Tax=unclassified Nitrosomonadales TaxID=1660158 RepID=A0A0R2V886_9PROT  ali  9  3..................................................................................NLLIFGVGLIGGSIA-LKVKKDTIFDRVVGMGRDKGRLDSFVKNGDEVAKNIGEAISSADLIVIAAPVAQ-TRSILKNIHPYLPVDCLITDVGSTKSNVMLDAKEILG------EKFNQFIGSHPIAGSEKHGPEIVITPHTNKQQIELLEKFWLSMGGIVSTMNPSQHDEIFSTVSHLPHLLAFALVN-LINNKKSKDQLLEFA----ASGFRDFSRIASSPEVWRDISLANKKAVVKEIVRLIRLIDEKQTDELNDYLSEAS. 277
290 5.000e-51UniRef50_A0A1V5VG32 Prephenate dehydrogenase n=1 Tax=bacterium ADurb.Bin236 TaxID=1866925 RepID=A0A1V5VG32_9BACT  ali  13  9..................................................................................KMAILGVGLLGGSIAKTAKK-NGMVSRVSGHGRNPERIGYALRNGIEAAATPEEAVRGAELVVVCTPVG-LISETIERISVCLEPGAIVTDVGSTKTTIVRNAEAIL-------PDSVSFVGGHPMAGSEESGVELASSDRTNISALNRIARFWEAMRSQVMIMSPEEHDLLVAASSHLPHMVAVALTRCVAEISADREKVL----PLLAGGFRDTTRIASSADMWRDICLTNPEFIGAVMERFG.................... 256
291 5.000e-51UniRef50_A0A1Y3QF99 3-hydroxybutyryl-CoA dehydrogenase n=3 Tax=Terrabacteria group TaxID=1783272 RepID=A0A1Y3QF99_9FIRM  ali  12  1...........................................................MGHGIAQVAAMAGYSVLLYDVSPDALARGLEQIHWSLDNLVRK-------------GRLTEQDAADARIGTGTSLADAVGEADLVIEAVPENELKLQVLAEVDRLAPRHAVLTNTSQFSITRLGAATRRPE-------RVCGMHFFNPPVL--MKLVEIARGARTSDETHRLVVEVSRRMGKETVTC-KDSPGFITTRLIGLLWVEAMRILEEGVASAEDIDHAMGPLETADLSGLDVAYAIAQS........................................... 234
292 5.000e-51UniRef50_A0A2D9MZD4 Cyclohexadienyl dehydrogenase n=9 Tax=Verrucomicrobia TaxID=74201 RepID=A0A2D9MZD4_9BACT  ali  17  36.....................................................................................................KERGLAKRVTALVRRPESVSECQALGVEVTLDEAEAISDADLIVLCTPVASMA-GLAKRWLQHLKNGAVVTDVGSTKRQLVDELT------PMIAGAGAHFVGSHPMAGSAQAGCVVTPTDATDAEALISVNEFWENLGSEPVAMSADDHDQLVARCSHLPHLLASALARRVLDPSHG-----ELQKQLCATGFRDMSRLASGSPMWRDIVRSNREAILAELDQLRQLISEDSSEAIEGWLDEAKR 292
293 5.000e-51UniRef50_A0A2G2I9Y2 Prephenate dehydrogenase n=7 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A2G2I9Y2_9GAMM  ali  12  4..................................................................................RLAIIGVGLIGGSLSLALKKA-GVVSEVTGYSRTPSVRKEALQLGVHAAASIADAVKDADMIFVAVP-MAAMEIVLAELAEHVKADAIITDGGSAKGQVVDVAKKVLGD------KFRQFVPGHPIAGTEKSGHRVVLTPVTNVDALAKVRSMWQNTGAEVFDMNVEHHDDVLAATSHLPHILAFNLVGML-AERDDCDEVLRYA----AGGFKDFSRIASSDAMWRDICLTNKDAILE.......................... 245
294 6.000e-51UniRef50_A0A2A4YKY1 Prephenate dehydrogenase n=1 Tax=Candidatus Aerophobetes bacterium TaxID=2030807 RepID=A0A2A4YKY1_9BACT  ali  10  4.....................................................................................................KSFDVGIIGGDGKMGSFLKKAFEKEHTVYVSDNVDLVKKCNVIIVSVPIRE-TVSVIEEISPHLTEDHLLLDVCSLKEKPCRAMAK----------TKAHVVGMHPMFAPSMENQTVVLCPLKETPRLSCMKGFFESAHARVVVTTPENHDKMMGIIQCLTHFISIVYVLTMKNLDVEIKELVDYASPVYLIELLMSGRILAQDSLYTDIQMQNPKAFSEATLFLETLVKEGNVDGFEKTFEE... 251
295 6.000e-51UniRef50_A0A0N8A0S4 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial n=8 Tax=Bilateria TaxID=33213 RepID=A0A0N8A0S4_9CRUS  ali  11  8........................LLRTPYMMASFRRNLITSNSTQMAIKNVVVIGGGLMGSGIAQVAAQNGQNVTIVDLDQKVLDKAKNSINISLQRIAKKLFK-----DDSVKAEKFLSDSM-AHVTLSTNPEQAVNQSDLVVEAIVEKNIKQKLFQTLDAVAPTHTVFANTSSLPIGEIAQSTNRKD-------RFVGLHFFNP--VPVMKLLEVIRIPETSDDTYNLVMEWGKSIGKQTVTC-KDTPGFIVNRLLVPYMMEAVRLLERGDATARDIDTAMKL............................................................. 255
296 6.000e-51UniRef50_R6PQY6 3-phosphoshikimate 1-carboxyvinyltransferase n=10 Tax=Clostridiales TaxID=186802 RepID=R6PQY6_9FIRM  ali  13  17................................................................................................KALKEKTN---IEIVAMNRSEKSLIDAYNDGVKYSLTDMSIFKECDIIIVCTTVDTI-PTYVSKLKPYIKKDCIITDVGSTKKKICDTLSNI---------KDICFIGGHPMAGSEQTGYKYILTPNVPQSKIDKMINIAKTLGATPVVISPEVHDYTVAAISHVPHIIASSLVNTVKE----LADSDGYMHSFAAGGFRDITRIASSSPVWNSICQDNREPILNVLDTYINTVREENKEDIYSFFENARD 271
297 6.000e-51UniRef50_A0A2I0NY01 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=5 Tax=Methanomicrobiales TaxID=2191 RepID=A0A2I0NY01_9EURY  ali  13  2........................................................................................................RVGIIGGTGQMGSFFTRVFEDAGHEVTVSSEDLAKDSDILIISVPIHSTIP-VIHQIAPLLHKGQVFCDLTSLKSGPVNAML----------CSQADVIGLHPMFGPSLQGQTIIATPARSDEHRELLTDLFTSQGARVTVTTPEYHDRMMAVIQGLTHFKALVMADTMRMLGITPEETEPFMSPIYRIETSVAGRILAQDPMYADILSENPETCCKAALSLTSIISSGDTEAFIERFIAERE 251
298 6.000e-51UniRef50_A0A2H0LZP2 Uncharacterized protein n=1 Tax=Candidatus Omnitrophica bacterium CG11_big_fil_rev_8_21_14_0_20_42_13 TaxID=1974746 RepID=A0A2H0L  ali  14  25.....................................................................................................RQRGIASRVIGISRTKKTINKAKKAGADGFCDFKP-LSDCELIILCSPVN-IIINTLSKIKPFISPGTIITDVGSTKSEIVKSA-------GMILPKGADFIGAHPLAGSEKSGIVCVLTPLKSKKNIRRLESFWLALGSRVSFLTPSAHDKITSFTSHLPHLIAFNLLESIPAVDL----------RYAASGLRDATRIAASDPLWADIFISNRAAILKSADKFLKLLKSGDSKRIIQVIKKAK. 273
299 6.000e-51UniRef50_G0EH62 NAD-binding 3-hydroxyacyl-CoA dehydrogenase n=5 Tax=Desulfurococcales TaxID=114380 RepID=G0EH62_PYRF1  ali  14  1.........................................MPLRPEEIKTVLVVGAGVMGHGIAQVFAMNGYRVRLVDIKEEFLRRALERIRASLEKLASK---------GALREPI---DAVMARIETSTDLRKAAEGIDYMVEAVPEKEIKRQVFKTVDEVAPPHAILTNTSSIPISEIAEATSRPE-------KVAGMHFFNPPQI--LKLVEVVRGAKTSDDTVETIVALAKRLGKEPVVVRKDVPGFIVNRVMIRILNESCRLVEVDAALRFKLGFPMGAFELADYIGLDVL................................................. 246
300 6.000e-51UniRef50_A0A1G3BR92 Uncharacterized protein n=5 Tax=Planctomycetes TaxID=203682 RepID=A0A1G3BR92_9BACT  ali  12  23.....................................................................................................KKRNLASKIIGVCHRTSSIEKAVKAIDAGFLNANEAVKDADIVILATSVDKII-DLAKEIIPIMKSDSILTDVGSTKALIVKQITNNI-------REDIAFVGAHPIAGSEQRGIEVIITPLKSTKAVETISTMWQLMGARVKFMSPEQHDEILASVSHLPHLVASCLINSIKKEHINY----------VASGLRDTTRIASGDPLWANIFDQNRDNVIKSIEQLILNKFKNDL............ 255
301 6.000e-51UniRef50_A0A0F4ZH93 Uncharacterized protein n=5 Tax=saccharomyceta TaxID=716545 RepID=A0A0F4ZH93_9PEZI  ali  15  2..............................LTSQIARSTRAYSTTASAVNKLGVLGAGQMGLGIALVAATAGVSVSLVDSSKKALDKGLAFADKLLAK-------------DVAKGRLSSDDAAAARARLTPELMDAFSDADFIIEAVPIPQLKLDIFAKLATIAPPHAILTNTSSISITKIAAATAPDPTDLSVSQRVVSTHFMNP--VPVQKGVEIISGLQTSSATVAAAVGFVERMGK-VASVSADTPGFLANRILMPYINEAIICLETGVGSREAIDGPMGPLQLADFIGLDTCLAIMKVLHSETGDSKYRPSVLLGNMVNAGWLGKK............... 299
302 7.000e-51UniRef50_A0A0B0HKF1 Prephenate dehydrogenase n=1 Tax=Anoxybacillus sp. BCO1 TaxID=1548750 RepID=A0A0B0HKF1_9BACI  ali  13  1...............................................................................MRGNVLIAGLGLIGGSIALAIKRVHPDA-TMIGYDVSGESLRLARSLGVEAVPSFAHAACEADVIVLAAPVAQ-TEQLLRELVALLRPDVIVTDVGSTKERIVKQA-------WPLLEQGVTFIGGHPMAGSHKSGVILTPTEHVKEEQITRLKRWLEGTKAHFVTLTPKEHDRIAGVISHFPHIIAASLVHQAQQYEREDE----LVSRLAAGGFRDITRIASSNPMWRDIFIHNKEELLHLFDRWIEEMKK............... 257
303 7.000e-51UniRef50_A0A1F5U0Z4 Uncharacterized protein n=2 Tax=Candidatus Firestonebacteria TaxID=1817802 RepID=A0A1F5U0Z4_9BACT  ali  13  24.....................................................................................................RKQKLAGRVIGIGRNEKKLKNAVKLGAEYSLDYW-ILGEADLVFLATPVVHI-EEMLTKIGPYLKAGALVTDGGSTKENIVSAANKYL-------PLYTYFVGSHPIAGSEKSGVQFAVCAVTPDKALSKIRNLWKKLGANVVTLSPAEHDKILAATSHLPHFVAAAMEVSVISKNKN------LLSLIGK-GFKDTTRIASSPEVWAEIALANKKNVCKSMKEFIKAIKRGRSKDIVMILKEAK. 275
304 7.000e-51UniRef50_A0A2N2D2X2 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Firmicutes bacterium HGW-Firmicutes-15 TaxID=2013776 RepID=A0A2N2D2X2_9FIRM  ali  13  8.......................................................GAGIMGAGIAQVAAEAGYSVILRDLQNSLVRDGLTTIENNLDK----------RIIKGELNK-DMRSAILNRIHGTIDLAE-LKDVDLVIEAVVENAVKKQIFTELDNICSEDTILTNTSSLSITEIASSTRSADRIL-------GLHFLNP--VSQMKLVEIVKGMETSDATVNIACEFVSRIGKEYLVVNRESPGFIVNRILVPYINEAIFVASIDKAMKLGAGMTMGPLEMADMIGLDTLYAVLLVFYNEFRDPKYRPHTVLSTMIRAGYLGKK............... 273
305 7.000e-51UniRef50_A0A239HKV0 Prephenate dehydrogenase n=1 Tax=Anaerovirgula multivorans TaxID=312168 RepID=A0A239HKV0_9FIRM  ali  13  4................................................................................FQEILIIGMGLIGGSLSLALKKS-GYQGKIIGCDLSKEALIEAKAMGAIACEVPQEAVKNADLIVIAVPVGYY-DEVFKEIAAYLPKGVVITDVGSIKGYVETAVARHL-------PKDIQFLGGHPMAGSEKGGIKAALTPNTRRDTIEKLESLVKGIGAYPVIVEAREHDKIVAQISHIPHLA-----AVLLASLLEKRNSTSYI-PFVGGGFRDTTRIAAGNPMWKDIFFLNKGEVLELLQDFKSKLLEGKQEEVLEALEKAK. 277
306 8.000e-51UniRef50_R7ZQS0 3-hydroxybutyryl-CoA dehydrogenase n=223 Tax=cellular organisms TaxID=131567 RepID=R7ZQS0_9BACT  ali  13  7........................................SLKANTLILPKERKKGAGTMGNGIAHVFAQQGFEVVLVDLSAERLEKAVQSIALNLDRQVRKGIISVEEKPGI-----------LARINTSTHLENGTRVAELVVEAASEDAIKRDLFRELDRLCPPSAILTNTSSLSITALASCTKRPE-------QVIGMHFMNP--VPVMKLVEVIRGYSTSDEVCSAVMQLSRQLGKDPVEVN-DYPGFIANRILMPMINEAAGVEEIDTVMRTGMAHPMGPLQLADFIGLDVCLSILRVLQQGFGHPKYAPCPLLVNMVEAGM................... 291
307 8.000e-51UniRef50_A0A2D6MYC6 Cyclohexadienyl dehydrogenase n=4 Tax=Deltaproteobacteria bacterium TaxID=2026735 RepID=A0A2D6MYC6_9DELT  ali  12  1.....................................................................MSGSDATQFAPFEKLAVVGLGLLGGSVAAAA-KERGLAREVVGAARRSAPLERALAAGIVDSVAPADAVIDADFVILGTPVGSM-PKVVSEIGLGLGTGCLVTDVGSVKGFVV-------EMLPGLLPAGVEFVGSHPMAGSHLRGPECVVTPRVGQDAIERVECFWRDVGARVERRSPVIHDEQVAWVSHLPHLVAFAFAESLSAAPTQVG-------LLAGGGFRDFTRIAQSDELWGEIFSLNSKALSQSLAKLARALEQGDSESLEQLLNQAR. 283
308 8.000e-51UniRef50_A0A1G3ZUE0 Uncharacterized protein n=1 Tax=Verrucomicrobia bacterium GWF2_62_7 TaxID=1802432 RepID=A0A1G3ZUE0_9BACT  ali  15  20..................................................................................................LAARARQIAGRTVLWARRPEACDEAMTAGAADAATLDEAVCAADLVILATPVG-VMGELAAKMAPSLKPQALVTDVGSVKYPVVTQLEHLLAGKAR-------FVGSHPMAGSEQSGIILTPTERTDAGALQQVAEFWKSLGASVRTLTATEHDEVVARVSHLPHLVAAALVNLVCS---DGPRPLEFAG----GGLRDTTRIASSPPMWQEICLTNRDEVCRALAQFI-----EQLEAVQTMLRNKED 264
309 8.000e-51UniRef50_A0A2I0Q734 Prephenate dehydratase n=10 Tax=Archaea TaxID=2157 RepID=A0A2I0Q734_9EURY  ali  15  23......................................................................................................................FKKFFEEAGYEVSLKPEELAQKADILIYSVPIKD-TIDIIMKTAPFAKPGALITDFTSVKTQPVEAML-------RYAPESCEVVGMHPMFGPTIKNQIVVLCKCRGTKWYAWLKNFLEKNSAVVKETTPQKHDKIMSVVQGITHFSSLVTARAIEKSGLSLKETLDFASPVYKLQLYTIGRILAQNPLYASIQMDNPEIRRRTEQEISDIVKNKNYSNFVKKFNDVS. 259
310 9.000e-51UniRef50_A0A0K1PQJ5 Prephenate and/or arogenate dehydrogenase n=1 Tax=Labilithrix luteola TaxID=1391654 RepID=A0A0K1PQJ5_9DELT  ali  15  75...........................................................................VVRDVYARLFAASRLEQRRILQTKAEHFS-VGIIGATQGMGAFLARVLKNGGFEVETKAEEVASRNDLVIVAVPI-AATVDVIRRIAPHVRPGACLMDITSIKSAPLKAMLE-------AAPEGVDVVATHPMFGPHFDRQKVVLCRGRGDAAFARVKKLFESFGAETIEATAEEHDAQMALIQVLVHEKTMVLGSVLERLKADLGRSLQFASPIYRTELAMIGRMFSQAELYADILTVNPEAFEQEAAHFARAVAMGDRESVVKRFREVAE 354
311 9.000e-51UniRef50_H7FRZ5 3-hydroxybutyryl-CoA dehydrogenase n=121 Tax=Bacteria TaxID=2 RepID=H7FRZ5_FLAFP  ali  15  1................................................MKVIAVIGAGTMGNGIAHTFAQSGFTVKLIDLSEKSLDKGMATIAANLDRM-------------VTKGTITQEDKAKTNIITYTDIKDGVVGADLVVEAATENELKLSIFKQLNDACSHNTILTNTSSISITQIGAVVAHPE-------RVIGMHFMNP--VPIMKLVEIIRGYNTSDVVTKTIMALSEKLGKTPVEVN-DYPGFVANRILMPMINEAIGVYEIDTVMKLGMGHPMGPLQLADFIGLDVCLAILNVMYDGFKNPKYAPCPLLVNMVRAGKLG-VKSGEGFYDYSESKK. 286
312 9.000e-51UniRef50_A0A2H0LPU5 Uncharacterized protein n=1 Tax=Candidatus Omnitrophica bacterium CG11_big_fil_rev_8_21_14_0_20_45_26 TaxID=1974748 RepID=A0A2H0L  ali  13  23...................................................................................................REKFPKARIIGVSRSKIKIRLARHKKCITSGFTSFQPALKKADMVFVCTPVDTIIP-LLKKIDQYAKPGTPVTDVGSTKSQILRSVQKR------GAFKHIHFIGSHPMAGSHLTGVFVTKHPKMNSKAFRQVIALWKRICGRVIILTPEQHDKIVSEISHLPHVIASLLAEIASST------SLKYAST----GFRDTTRVAGDSALWLPILMTNRNNLVRLLSRFR-----KRVQALEDYLRRGN. 261
313 9.000e-51UniRef50_A0A1M7SHM7 Prephenate dehydrogenase n=6 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A1M7SHM7_9RHOB  ali  15  103.............................................................................................................IVGHARSAATRETAARLGDEVFAAPAECVRDADLVILCVPVGAM-EATARAIAPALKPGAVVSDVGSVKAAVIEAVAPHL-------PEEVHFIPAHPLAGTEHSGPECILTPGSDRGQVARLRRLWEGCGANVDEMDPAHHDLVLAVTSHAPHLIAYTMVGVADHLRRVTDEVIKYS----AAGFRDFTRIAASDPMWRDVFLNNKEATLEILGRFTEAIRMGDGDLLFDYFTRTR. 351
314 1.000e-50UniRef50_A8MB93 3-hydroxyacyl-CoA dehydrogenase NAD-binding n=2 Tax=Caldivirga maquilingensis TaxID=76887 RepID=A8MB93_CALMQ  ali  16  13.......................................................GSGTMGHGIAEVAAISGFSVHLNDLTLDILQRALNNIRWSLDNLHRKGQ--LKEEPSEVMSRIS----------VTTSLEDAVKNADFIIEAVFEDNVKSSIFRRISEYAPPHAILANTSSIPISELASVTNRPD-------KVIGMHFFNPPVL--MKLIEVVRGDRTSDETVNVTVELGRRLGKEPVVVNKDVPGFISNRV-FMRLIEAACLMAIDSAARFKLGLPMGVFELIDFVGIDVVNSIL............................................. 248
315 1.000e-50UniRef50_P43902 T-protein n=1903 Tax=cellular organisms TaxID=131567 RepID=TYRA_HAEIN  ali  14  37.............................KVKHQHGLPIYAPEREIAMLQARRLE------AEKAGISA----DLIEDVLRRFMRESYANENQFGFKTINSDIHKIVIVGGYGKLGGLFARYLRASGYPISILDREDLANADVVIVSVPIN-LTLETIERLKPYLTENMLLADLTSVKREPLAKMLEVHTGA---------VLGLHPMFGADMAKQVVVRCDGRFPERYEWLLEQIQIWGAKIYQTNATEHDHNMTYIQALRHFSTFANGLHLSKQPINLANLLALSSPIYRLELAMIGRLFAQDELYADIIMDKSENLKQTYDEALTFFENNDRQGFIDAFHKVRD 351
316 1.000e-50UniRef50_A0A098EBY3 Putative arogenate/prephenate dehydrogenase n=8 Tax=root TaxID=1 RepID=A0A098EBY3_9ZZZZ  ali  16  44...................................................................................VIIGGYGGMGKIFVKIFKDYGNVIITGPSKEKGE---KTASDFGVKFSDDNRIAMS-ADITIITVPIEK-TIATIKEVAPLVRDGSLITDFTSVKTDVCDALLK-------YTNKNAEIISIHPMFGPTISGQIFIICPLRTEKWLFVIEKFLNYHKAKFVTATPEEHDKAMSVIQGLTHFTYISIGYTLKNMDFNVRESRKFASPIYNLMLDIIGRILSQDPLYAHIQMENPKKFIESAIAINDSINSKDEKNFVSIMSSSAK 306
317 1.000e-50UniRef50_A0A2E9Z3C8 3-hydroxybutyryl-CoA dehydrogenase n=3 Tax=unclassified Nitrospinae TaxID=1449243 RepID=A0A2E9Z3C8_9BACT  ali  14  10.......................................................GAGIMGAGIAQRAATFGFSVTLVDKDDACLHAAEKRMAKSLDKMVEKGIILKDIEYDV----LTL-------VAMTTDIK-AVSSSDLVIEAVNENELKQKVFMKLEQICPSNAILTNTSSIPIASLANVTRSPQ-------RVVGLHFMNP--VPVIPLVEVIRTDQTSDATFEACIEFLEEMQCETVQ-SKDSPGFIINRILIPMINEAVKVLESGVASAEDIDQPMGPLALADLIGLDTVVHILETLYAGFNDERYRPCPLLLDYVRGNRLGRK............... 274
318 1.000e-50UniRef50_A0A1R3URX6 3-hydroxybutyryl-CoA dehydrogenase 3-hydroxyacyl-CoA dehydrogenase n=16 Tax=Streptosporangiales TaxID=85012 RepID=A0A1R3URX6_9ACT  ali  13  14.........................................................GTMGAGIAEVFARAGFNVVGVEIDQAALDRGRGHVDKSLSRA-------------VDKGKLTEEERAGIDARFTFSAREDLSDADFVVEAVPEMDIKRDVFGDLDRICAPGTILTNTSSLSVTEIAALTDRPE-------KVVGLHFFNPA--PVMKLAEVITTVSTADETVDVVTEVAKRIGKTPITVG-DRGGFVANALLVPYINDGIRLYERQIATREEIDEPMGPLTLADLVGLDVCLAVMDVWEEFRD-PRYAASPLLRRMVAAGRLGRK............... 276
319 1.000e-50UniRef50_A1RUG3 3-hydroxybutyryl-CoA epimerase n=1 Tax=Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) TaxID=384616 RepID=A1RUG3_PYRIL  ali  13  8.......................................................GAGTMGHGIAELFALAGYEVNLVDISQDILNKALRNIEDSLKKVKER-----------GRLKEDVATVLSRIRPVVGDVCSAVVGVELMVEAVVEDEVKKRVFAEADRCAPPEAILTNTSSLPITEIAEAVK-----PERRTKVVGMHFFNPPVL--MPLVEVIKGQYTSDETVKRVVDYVKKLGKEPVVVNRDVPGFIVNRILARVNEAACWLVARGLSTPEVIDAPMGVFLLMDFVGLDVVCFVAE--AMKKRGFKSHPCPILEKCQQKKYGVKSG--EGFYKY...... 282
320 1.000e-50UniRef50_B1YIJ7 3-hydroxybutyryl-CoA dehydrogenase n=103 Tax=Bacteria TaxID=2 RepID=B1YIJ7_EXIS2  ali  16  7....................................................VVVGSGVMGRGIAYVAAASGFDVTLVDVEQQLLASAQQELETIADK-------------GVSRGKMTTEEVGQLRLRYATDLEEAVKEADLVIEAVPEREIKRMVFETLDRHAPAECVFTNTSTMSPTEIASFTKRPERVMA-------MHFFNPVH--RMPLVELARGLETSDETVMICETVAQQMGKETVVIQ-EFPGFVTSRISALVGNEAFYMLEIDKAIKLGLNYPMGPFELGDLVGLD--TRLNNLKYLEKLGEKYRPAPLLEQYVKAGRLGRK............... 274
321 1.000e-50UniRef50_A0A1V4ME29 Uncharacterized protein n=1 Tax=delta proteobacterium ML8_D TaxID=1775672 RepID=A0A1V4ME29_9DELT  ali  13  22.....................................................................................................SRPTVGIIGGLGRMGRWFAKFFQDAGFPVELRPEDLARQCQVIILSLP-MQVFPKVVAKLGPIIPENSFLTDLCSLKQSQVACMLEC---------ACCEIAGTHPLFGPSMKGRRVALCKGRGKRWFTWWEGLLRKHGAVTSVVSPEEHDRTMAWTQALNHFILLCLGKAMDDHGIDPKQIMALATPSFEQQMEILARLYHQDPLYATIQMSNPYTVLETFANLRKIIKERDRKAFIELFEEVQD 274
322 2.000e-50UniRef50_UPI00069B83BC prephenate dehydrogenase/arogenate dehydrogenase family protein n=3 Tax=Thermogemmatispora TaxID=768669 RepID=UPI00069B83BC :_  ali  13  23......................................................................................................KAKATREVTGYDLGRGVCEQARKVGAQAYDSLADAVRGAELVVLATPVGAM-RALLQHLASCVTPGTVITDVASTKAQVISWAEEFL-------PENVSFVGGHPMTGKEVSGVELTPTPRTRPSAVNKVATFVEALGARIRFLEPAEHDGQVAYVSHLPFVASIALMTTAVEAP-----SWGDAALLASSGFRDMTRLAANPEMYRDICLTNSEALVRSLNELALTRLRDRIAALNEVFARAQE 276
323 2.000e-50UniRef50_B3V5T8 Enoyl-CoA hydratase n=1 Tax=uncultured marine crenarchaeote AD1000-56-E4 TaxID=526641 RepID=B3V5T8_9ARCH  ali  11  1..............................................MEIKNITVLGSGIMGHGIAQVSAMAGYNVVLRDIEQPFLDKAMEKIKWSLDKLVSK-----EKISENERDEIF------SRIKPIVDLKDAVHNCDLVIEAVPIMELKKKVYAELDKAASDQVVFANTSTLPITEIANTISRP-------KKFIGIHFFNPPQL--MKLVEVIPGQETSDDITNLTINFVKSVNKIPVTCRKDVPGFIVNRLFILVHEACYVMEEIDSAVKFRLGFPMGIFELADFTGLDVI................................................. 242
324 2.000e-50UniRef50_A0A0F9ME27 Uncharacterized protein n=1 Tax=marine sediment metagenome TaxID=412755 RepID=A0A0F9ME27_9ZZZZ  ali  14  2..............................................................................DKVKKVAIIGTGLIGGSLGLAIKKSQD-PPKVAGFSRTLKNTERAVERGAIACIDIETCVKDADVIFIATPVGQI-VGIAKEISKVAKNGAIISDVGSTKSSIVKTIEEQL-------PKDIHFIGGHPVTGSEQDGIEFAPTEYTDSIAFKTLHNLLKSIGANVIAVDADKHDEILATLSHLPHMLAALLVNMASKQIGEKQNWLALA----AGGFRDTTRIAASNPIWLDICLENRKALVENLKELTALLEKGDTDKIRDVLTSARD 280
325 2.000e-50UniRef50_UPI00083DD0DC prephenate dehydrogenase n=3 Tax=Streptococcus TaxID=1301 RepID=UPI00083DD0DC  ali  13  4.................................................................................RVVYIAGLGLIGASIALGIKRDHPDV-EIWGYNRGEDSRRIALEKGDRVTDDFLSLAPEADVIILAVPIQQ-TIAFLQDLSRILKKDVIVTDAGSTKFEIVKAAENYL------TDRGISFVGGHPMAGSHKSGYIFTPSNLTTDQTIPTLKEILSGLHARFIEIDAKEHDRVTGQISHFPHVLASSLMEQAADYARDHEMVQQFA----AGGFRDMTRIAESPGMWTAILMTNPAEILERIEDFKL-----RLDKVSELIRQED. 268
326 2.000e-50UniRef50_A0A2V7Z1R7 tRNA (Adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE n=1 Tax=Acidobacteria bacterium TaxID=197  ali  11  99.................AGPGVKVVEWAERLPFDVLGARV-LKLARLPNAAEGEWRGGLMGSGIAEVAARSGYDTVVREITEELVDKGLQKIGGSLGKAVER-----------GKLEASVRDETLSRLSGTVKLED-LADCDIVIEAIVESDEKKKIFSTLDEVVKKDALFANTSSLTMTQIAMFTHRPD-------QVVGLHFFNP--VPVMKLVEVVRTLLTSDDSYDRAFEFARSLGKEPIAAR-DNSGFIVNRLLVPYLLDAIRALEEGVGSVEDIDKPMGPFTLLDFVGLDTTYYIANIMFEEYREQRFAPPPLLKQMVTAGRLGKK............... 400
327 2.000e-50UniRef50_A0A219AIE7 Prephenate dehydrogenase n=1 Tax=Methanobrevibacter sp. 87.7 TaxID=387957 RepID=A0A219AIE7_9EURY  ali  12  8.......................................................................................GTKGLGKTLACFLKKDNFNVIITGRDEK--VGKKVSHKLNIEYTSDNLEVAKNVDILVISVPI-HVTIDVIKKLAPHMKKGSLIMDVTSVKTQATYTMDE-------YIPEGVESIPTHPVFGPGFEGQVIVLTPLKKGKWYPKIYNYFKSKNMRIIETNCKHHDNMMGIVQVLTHFSYISTAYAMEKLKVNIKETEEYESPIYNIMIDTIARIVSQNPLTYSIQKENRQKFFDAVLELKEVLTSKNQKKFIEIANKSTK 267
328 2.000e-50UniRef50_UPI00046F80C1 prephenate dehydrogenase/arogenate dehydrogenase family protein n=3 Tax=Alphaproteobacteria TaxID=28211 RepID=UPI00046F80C1 :_  ali  16  13.......................................................................................GPGLMGSSVLRRLRATPGLVDTLVVTDRDPLSRVHALDLGDIVTADAQEAVKDADCVMLCVPVGAMAP-VATAILPHMKPGAILTDVGSTRRSVADAVSPHM-------RDDIAYVAAHPMAGTEHSGPDCLLTPKAPQDAIDRIAAFWDAMGARIRVMDIDQHDTICAMVSHLPHMIAFTICGTADTLAEEMRTEVLDF---AASGFRDFTRVAASDPMWRDIFLHNKDALLSVFDRF-----SQDMADMAAAIREGDE 272
329 2.000e-50UniRef50_D5WQ09 Prephenate dehydrogenase n=2 Tax=Kyrpidia TaxID=1129704 RepID=D5WQ09_KYRT2  ali  13  15.......................................................................................GCGLIGGSLA-LAWQRAGVAREIVGVDVSAEHLEIALEIGIDRALPLRSAVQEADLVVLAAPVKESM-ALLREIAAHPAAGTLITDVGSTKRAICREATRVL-------PEGVSFIGGHPMAGSEKSGIVLTPTPGEKPEMIQRIRDLVQAAGAQVLILDPDHHDRLVAAVSHLPHVVAAQLVHQVAELGEDD----PLYAVLAAGGFRDVTRIASGHPMWRDILLTNGDRLRDQIEELLGWINRRDGEALETFFRQAAR 284
330 2.000e-50UniRef50_A0A1V5Y1Q7 Prephenate dehydrogenase n=1 Tax=candidate division BRC1 bacterium ADurb.Bin183 TaxID=1852823 RepID=A0A1V5Y1Q7_9BACT  ali  10  14.......................................................................................GVGLLGGAIGR-KSKEIGLARHVIGIGRDRQRLESACAMGAEWTTDIQKGVTDCELLILCVPVQKII-EYMPIVAKSVSSGTIVTDVGSTKKSIVETGKNLF-------HDNIFFVGSHPMTGSDKSGCLVAVAPETDYAAAAKVALFWKALGMIPVIIDPTRHDDYVALVSHVPHLVSAALANAVSMCPEDLN----FIRQICGKGFRDTTRLAGDPPMWVEIFLENRQNIVNYLDGFIKM-----LARIKAAINNGDK 271
331 2.000e-50UniRef50_Q02394 5,10-methenyltetrahydromethanopterin hydrogenase n=68 Tax=Euryarchaeota TaxID=28890 RepID=HMD_METKA  ali  55  6....KVAILGAGCWRTHAATGITTFKRACEVADETGIKEAALTHSSVTYAVELKHLAGVDEVVLSDPVFDAGFTVVDVDLDEFIKAHLEGNPEDVMPKLRDYVNDIADDVPKPPKGAIHEEMEDKLDIVVTTDDAEAVEDADMIISWLPKGGVQPDIFKKIIDDIPEGCIVANTCTIPTRQFKEMFEDMGR------DDLQVTSYHPATVPEHKGQVFVAEGYADEEVVEAVYELGEKARGLAFKVPGYLLGPVCDMASAVTAIVYAGLLTFRDACTDILGAPVDFTQNMAVEALQMMAKFMEEEGLDKLEEALDPAALTNTADSMNFLADTEILPKALEVLEKYSK 355
332 2.000e-50UniRef50_A0A2P4JCY9 Putative 3-hydroxybutyryl-coa dehydrogenase n=4 Tax=Eukaryota TaxID=2759 RepID=A0A2P4JCY9_QUESU  ali  15  125.......................................................GAGQMGLGIALVASMAQVPVTVVDTSQKSLDKGLAFADKLLAK-------------DVGKQRLSQSDADATRGRLTTTSMDDLADVDMVIEAVPILDLKLSIFKSLANICPSHAVLTNTSSISITRIAAATTADPTDLSASSRVLSTHFMNP--VPVQKGVEIITGLQTSPETLATALAFCERMGKIP-STAADSPGFLANRILMPYINEAIICLETGVGQEKDIDDPMGPLQLADFIGLDTCLAIMEVLHSQLGDSKYRPAVRLRQMVDAGWLGKK............... 397
333 2.000e-50UniRef50_W0PFS8 Prephenate dehydrogenase n=3 Tax=Advenella TaxID=290425 RepID=W0PFS8_9BURK  ali  14  38.....................................................................................................KRNGVVGKVLGISHDPASINKALELGIIDTVASFEQISQADVIVIATPVSAF-ETVCDTIKPFLAPHALITDVCSTKKQVIAMARRSLG------ERVAQFVPGHPIAGAETSGPQVILAPLNTPEQIHLLTRLWEACGSTVSPMDAAEHDRIFAAVSHMPHFLSALYMYSLLGADQ-TDRKFKYAG----SGFRDFTRIAAGPPMWRDIFSSNRDCMLEEITRFQTC-----LERARHMLESGD. 279
334 2.000e-50UniRef50_A0A0D5ZG66 3-hydroxybutyryl-CoA dehydrogenase n=10 Tax=cellular organisms TaxID=131567 RepID=A0A0D5ZG66_9ARCH  ali  14  7.......................................................GAGTMGNGIAQVFAQGGNEVVLTDIVEPVLEKARDTIANSLERLSKK--GLISETPDQVKRRITFTKSIDDG-----------AGSDIYVEAIVEKELKKDILQKINEMANEDSIITNTSSISI-------NYLSGFVKHPENFLGMHFFNPP--PVMKLIEIVTGVRTSKKAVEKIQEISKDLGKEPVVV-KDYPGFVANRVLMPLLREAIVAYEEGVASKEDIDHPMGPLELADFVGLDVTYDVMKVLYDEFGDPRYKPPITLRNMVNAGLLGRK............... 270
335 2.000e-50UniRef50_D3E0A1 Prephenate dehydrogenase TyrA2 n=9 Tax=Methanobacteriaceae TaxID=2159 RepID=D3E0A1_METRM  ali  12  5..............................................................................DNKNMTIIGASRGLGKWIAQHLKEDFNITITSRNQAEGQ---EVANELKVSYNNDNIDAIKDANIIIFSVPIEHMA-TTIKEVAPHAPKGSLLMDVASIKKEPAEALEK-------YAPKDVEILPCHPMFGPTLKRQIVVLTPNRSNSWT-LVKEYLEKKECEIVITSPDEHDKYMSIVQGLTHFSFISLASTIKKLNINVKKSRSFSSPVYSLMLDMISRVVYQNPLYYSIQKNNRDALIKESMRLSKLIEEGDEEDFVKAIAESAE 273
336 2.000e-50UniRef50_W8SP37 Cyclohexadienyl dehydrogenase n=5 Tax=Alphaproteobacteria TaxID=28211 RepID=W8SP37_9RHOB  ali  14  2..........................................................................................................................................KDADLVVLAVPVGAM-EAVTREIAPHLAPGATITDVGSVKRDVIAAVAPHL-------PKGVHFVPGHPLAGTEHSGVLLTPDPGTAPEAVARLRALWEGCGANVEEMDADHHDLVLAVTSHTPHLIAYTMVGVADDLRRVTDEVIKYS----AAGFRDFTRIAASDPMWRDVFLSNKDATLEILGRFTEAIRTGDGDHLFDYFTRTR. 219
337 2.000e-50UniRef50_A0A223D1F3 Uncharacterized protein n=1 Tax=Tumebacillus algifaecis TaxID=1214604 RepID=A0A223D1F3_9BACL  ali  12  3...............................................................................MFEKAVLIGCGLIGGSLA-LALKQSHCVKHLTAVELNPQSCQLALSRAVHVADSLQDAVQDADLIVLATPVREMTLEVLAELP--LRPGCLITDVGSTKREICAEARRLL-------PASVVFIGGHPMAGSERSGVEYVLTPDSDPDVFAKWKWAVERIGAQVMVLDPNLHDEVVAAISHVPHIIAAQLVEQVAKLSLESESGALYA-RLAAGGFRDVTRIASGNPLWRDIVLSNRDVIRDLLQ-----GWQQSIHHFLGMLEQ... 269
338 3.000e-50UniRef50_A0A2H5Z3V5 Prephenate dehydrogenase n=7 Tax=Bacteria TaxID=2 RepID=A0A2H5Z3V5_9BACT  ali  17  35............................................................................................................RIVGFDIELLHQNEAKRIKARTTWTLAEALEGADLIVVATPPSAV-PEVFTTIAEHAPDGAVVTDTCSTKAAVMRWASEFL-------PARLHFVGGHPMAGKTQSGAVWVITPTASQQAIETVLGMVQALGAEPRFLDPEEHDSYVAAISHLPFLLSVTLMQVTSS-----DVAWREMRQLAAGGFRDTTRLAGSPQMYRDICATNAPAILRWLDRLIADGSEQALAELRETFERARD 285
339 3.000e-50UniRef50_A0A2V9YR99 3-hydroxybutyryl-CoA dehydrogenase n=4 Tax=cellular organisms TaxID=131567 RepID=A0A2V9YR99_9BACT  ali  14  10.......................................................GAGTMGHGIAHVFARSGYQVVLCDIEQRFLERALEAITKNLDR-------------ELAKNKITTDDKSAALRRITAVLDRGLANCDFAIEAANEKEIKAELFRDLDRICRPEIILANTSSLSITKLAALTKRAE-------KVIGMHFFNP--VPVMKLVEVIRGLATSKETLQTVCDLAARLDKTPVEVN-DAPGFVSNRVLMPLLNEAMYAVMEGVAAPEAVDHPMGPLTLADFIGLDVCLDIMRVLHQGLGDPKYRPCPLLKMVDAGWLGRKSGR............. 277
340 3.000e-50UniRef50_U3IIH2 Hydroxyacyl-CoA dehydrogenase n=19 Tax=Amniota TaxID=32524 RepID=U3IIH2_ANAPL  ali  11  40.................................................................QIAAASGHTVVLVDQSDEILKKSTKGIEESLKRVTKK-----KFADKPEAGAEFIEKTLK-NLTTSTDAVAVVHSTDLVIEAIVENEIKNELFKRLDKFAPEHTIFANTSSLQITQLANSTTRQD-------RFGGLHFFNP--VPMMKLVEVIKTPMTSQKTFESLMDFSKAVGKSPVSC-KDTPGFIVNRLLVPYMMEAVRLFERGDASKEDIDYPMGPFELLDYVGLDTSKYIIDGWHLEPNNPLFAPSPLLDKLVAEKKLGKK............... 301
341 3.000e-50UniRef50_A0A1M3N778 Uncharacterized protein n=1 Tax=Myxococcales bacterium 68-20 TaxID=1895795 RepID=A0A1M3N778_9DELT  ali  15  76...........................................................................VVRDVFASLFAASRLDQRRFLQRSIESFS-VGIIGGTQGMGAFMAKVLRSAGYEVETSSEEVAASNDLVVLAVPI-AATVEVARKVGPSVRPGACLMDITSLKRQPLAAMLES-------TPETVDVVGTHPMFGPHFDRQKVVLCRGRGEAGFARVKKLYETFGAETIEATAEEHDAQMALIQVLIHEKTMVLGSVLERLKADLGRSLQFASPIYRTELAMVGRIFSQAELYADILTRNDEALEQEAGHFARAVAMSDRETIIERFRQVS. 354
342 3.000e-50UniRef50_A0A0P1MXK0 Prephenate dehydrogenase n=8 Tax=Candidatus Kryptonia TaxID=1855361 RepID=A0A0P1MXK0_9BACT  ali  14  3................................................................................FRKISIIGTGLIGGSIALSLKQSKGYDFIITGFDIDPSSLDIALELGAKKANSIEEAVNDADVVFLCTPIKEILQQI-HIVSKHAKSGTIITDVGSVKKIVLKEAEKI--------KNDVYFIGGHPMAGSERKGIVYVLCPNFNVKVVNEFIELIKLTGANIILLDPEIHDGIAGYISHLPQLIAVLLVNTVGSMGTD------YLSLSG-GGFKDLTRIASQFEIWHDIISFNREKIIEALDNFING-----LSKYREIIKSNK. 263
343 3.000e-50UniRef50_UPI0009DC3493 hypothetical protein n=1 Tax=Granulicoccus phenolivorans TaxID=266854 RepID=UPI0009DC3493  ali  13  1................................................MTKEISKVAGTMGAGIAEVFAKGGYAVRGIEYNDAALDRGRAILQKSTGRAVK-------------RGKMSEEDAAALRIQFSTDNTD-VSDCDLVIEAVNENELKASIFRVIDEAAPEHAILTNTSSLSITAIAAVTKNPS-------RVVGVHFFNPA--PVQKLVEVIRTLHTADEHVDRLIGLLRSLGKEPILCR-DRAGFIVNALLIPYLSNAVRLEELDSAMVEQAGYPMGPLQLCDLVGNDVALAVLERMYEETKDRRNAPPALLTSMVEAGLLGNK............... 276
344 3.000e-50UniRef50_A0A2K2V7C3 3-hydroxyacyl-CoA dehydrogenase (Fragment) n=1 Tax=Candidatus Korarchaeota archaeon TaxID=2056630 RepID=A0A2K2V7C3_9ARCH  ali  15  15.......................................................GAGTMGHGIAEVLAINGIKTNLVDIKEDILRSAMEKIGWSLRKLHEK-----------GRISRSPEEVISL-ISTFTSIKEAVRDVDLVIEAVPIFELKKQVFSEIDANSRPDAVITNTSSIPISELALCTRRPD-------KVLGLHFFNPPVV--MQLVEVVRGRDTSDDVVKQMMEFVRRIGKKPVLVRRDIPGFIVNRI-MIRLLNTACIVEEVDSALRKIGFPMGAFELSDYIGIDVLYFIIESVRS-RGMAIESCQTFKEMMDRGKLGVKTGD............. 280
345 3.000e-50UniRef50_A0A2E9RY96 Uncharacterized protein n=1 Tax=Opitutae bacterium TaxID=2026771 RepID=A0A2E9RY96_9BACT  ali  13  1...............................................................................MFNQITIIGPGLLGTSLG-MAIKAKDLAKKINVWARRPEVREACRRTDDADHSEIPEAVKGSDFVVVCTPVRHIK-AVLAKIAKVASSGCVVTDVGSVKGAICQAADKVFTASKAT------FVGSHPMAGSEKAGMEVTSGKDISVESLELVSNFWQAIGMSVTITTPNEHDEIVAHLSHLPHALASGLCHLLGKKSPTWGKLAG-------QGLRDTTRIASGNPLWEEIFLLNRESLLLALQSFEE................... 250
346 3.000e-50UniRef50_A0A1C6HMG8 Probable 3-hydroxybutyryl-CoA dehydrogenase n=5 Tax=cellular organisms TaxID=131567 RepID=A0A1C6HMG8_9FIRM  ali  15  7.......................................................GAGTMGRGIAQVFAANGHTALMYASSIASAQRHKEQLDASLQK-------------RVAKGKMSQGTKDALMANVLVEEESAAADADLVIECIEEMGPKKELFRRLDELCKPETVFANTSSLSITEMGHGLKH---------SLIGMHFFNP--VPSMKLIEVIRGVNTPQETFDFVYKLAQDIGKDPVEV-AEAPGFVVNKLLIPMINDAIGLVESGTASVEDIDHPMGPLALGDFIGLDICLAIMNTLYDETGDSKYRPALLLKKMVRGGLLG................. 266
347 3.000e-50UniRef50_A0A2E8RMC1 Prephenate dehydrogenase n=4 Tax=Candidatus Poribacteria bacterium TaxID=2026781 RepID=A0A2E8RMC1_9BACT  ali  12  5.................................................................................QQITILGVGLMGGSLG-LALKQNGFSGKIVGLGRKIERLEIAQSLKAKITTDFGQALLDTDLVVICTPVDQIIERVLRSVDS--SKSLILTDVGSVKSEPVHTIDQLL-----LECPNIEFVGGHPMAGSEKTGVSLTPTDNTSSLALKMVTQLWXSVGSAVYILTPDXHDSLLAAASHLPHLVASILAETVGKVMVNGEAATKYA----ATGFRDTTRIASSPELWNSIFLQNRSNMITMISDLI-----NDLQLFQTYLENXD. 271
348 3.000e-50UniRef50_A0A0T6AGT9 Prephenate dehydrogenase, prephenate dehydrogenase n=3 Tax=unclassified Deltaproteobacteria (miscellaneous) TaxID=122706 RepID=A0  ali  14  23.....................................................................................................KGKPGAPEVWGCDRRKESVRRAREAGAVARACTETEIAACDIVVVCVPVIR-SLGIIRRIGKRMRPGSVVTDVGSAKARIVRVGQKS-------VAPGAEFVGGHPIAGTENSGYIVTPAAGNSEAALRRVEALWRMAGARVVRMDPEMHDHVFAYVSHLPHAVAYALVHSVATLNSRV--PLGYS----AGGFRDFTRIASSNPMWKDIVLQNRVEILRATRNFALLIRGGDEKGLLAYFRKAKR 275
349 3.000e-50UniRef50_F6XHT8 Hydroxyacyl-CoA dehydrogenase n=14 Tax=Opisthokonta TaxID=33154 RepID=F6XHT8_CANLF  ali  12  15...............................................................IAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRRVAKK-----KFAENPKAGDEFVEKTLSS-ISTSTDAASVVHSTDLVVEAIVENKAKNELFKRLDKFASEHTIFANTSSLQITNIANATTRQD-------RFAGLHFFNP--VPLMKLVEVIKTPMTSQKTYESLIDFTKVLGKHPVSC-KDTPGFIVNRLLIPYLMEAIRLYERGDASKEDIDTAMGPFELLDYVGLDTTKFIMDGNPLFQPIPSLNK............................... 268
350 3.000e-50UniRef50_A0A1V6C5T2 Prephenate dehydrogenase n=1 Tax=candidate division TA06 bacterium ADurb.Bin131 TaxID=1852827 RepID=A0A1V6C5T2_9BACT  ali  15  24.....................................................................................................KELGLSKRISGFTRSPKTLERAISLGADGLLNFEEFIKDVDFVVLSAPISANIE--LARIIGRQKPSLLFTDVGSTKKEIVKMVEDFF-------PSGHRFVGSHPMAGSEKKGITVIITPVSSPSTIETIEDFWRKIGARTVRMDADTHDDLCAYTSHLPHLVAFLLVSVFSEKMDKPN-----ASACIGAGFRDTTRIAASDEIWSEIFLSNSENILNAIEKFKEMIEKKDAQSLKNMIEKIRK 278
351 4.000e-50UniRef50_A5CWH6 Prephenate dehydrogenase n=4 Tax=root TaxID=1 RepID=A5CWH6_VESOH  ali  11  22.....................................................................................................KQTNQVKTVIGFSRQESHLRKAQEMGIEYSLDISQVLKQVQMVIIATPVNSF-QAILEMIKPHIDESVIISDVGSTKGSVIQIAKLVFGQMPAK------FIPAHPIAGKEKSGIEVVLTPTESSDTIAILSGLWKELGAKVEIMTDKKHDDLLAMTSHLPHMLAYGLMDYLISNN-------PYACRYVAGGFKDFSRIASSDAMWRDICINNPKEIVKTLEKISNLIKNNKAEALEQLFQEAK. 275
352 4.000e-50UniRef50_A0A1J4VMN0 Uncharacterized protein n=1 Tax=Candidatus Omnitrophica bacterium CG1_02_49_10 TaxID=1805289 RepID=A0A1J4VMN0_9BACT  ali  14  6...............................................................................LFNKVAILGTGLIGGSLA-VDIKADGLARTITGACRSNVTLNKIKALRIEVTRDAAKAVEDADLVILATPVRAII-ELAEKVSPYLKRGSIVMDVGSTKQEICR-------RVSAALPAGVSFVGCHPMAGSEKSGFSFVVGKSF---ASAKANLLWKRLGADVVTLSAGEHDDIVAAISHLPHIAAAALVNSV------PKKALKFAS----GGFKDTTRIASSSELWNDIFMNNKVFVSKYLDRFISELKKRDGTGLRGRLERASR 272
353 4.000e-50UniRef50_A0A174EUF5 Prephenate dehydrogenase n=132 Tax=Bacteria TaxID=2 RepID=A0A174EUF5_9CLOT  ali  15  10.......................................................................................GLGLIGGSIARGIKREKPDTK-IMAYMRTRSRLLSALDEGIDVILDVNEQLSECDLIFLCTPV-EYNARYLAEIKPFLKPGAIITDVGSTKTDIHEAVTRLGMEDC--------FIGGHPMAGSEKTGFEYIITPTRSPEAVDRLISVASLIGSIPIVLDYREHDSVTAAISHLPHVIASSLVNLVR----DADNPEGLMKRLAAGGFKDITRIASSPEMWEQICMTNRAPLAAVLEQYIEKLKAGDNQYLSRLFETSRD 278
354 4.000e-50UniRef50_A0A2E5R622 Cyclohexadienyl dehydrogenase n=10 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A2E5R622_9PROT  ali  12  1...............................................................................MFQKTLIIGVGLIGSSLARGL-KNKNISDFIFGFDIDKIVQSKCNKLKIDKIINNFDKLDDFNLIILCSPLGSYK-EILSEIVPYIKKECIITDVGSTKLSVVKEFNKY------VNNKLIEFVPGHPIAGLEKSGPEYILTPENQESGVRKISKMWEKLGMKIEFMNPVHHDRVLAMTSHIPQLIAYSIVATATELEEKVEEIIKYS----ASGFRDFTRLAGSDPMWRDVYLLNKEPVLEML-----GRFSEDLSSLQKAIRNNDK 266
355 4.000e-50UniRef50_A0A117KX12 Prephenate dehydrogenase n=1 Tax=Clostridia bacterium 41_269 TaxID=1635275 RepID=A0A117KX12_9FIRM  ali  14  14.......................................................................................GVGLIGGSLG-MALKYRRAADHIAGYDVDYRVLKKAEELVDRGYSDLAEAVGGADLIILSTP-LSVFEDIAQRMLPFVKEDAVITDTGSTKACVVRKLERVFSNKG-------YFVGGHPMSGSEKGGIEITPTENSSRQAVEKVALLAGLIGSRPVFLSPEEHDAVVAAVSHVPHIAAAGLVLTLGE----LEKRHPCAPVLAAGGFRDTTRIAASDPLWEQICFSNRENYIDTLSRIKIYLEENNRNKFKKALAQAKE 283
356 4.000e-50UniRef50_A0A1U9NNC1 Arogenate dehydrogenase n=8 Tax=Planctomycetes TaxID=203682 RepID=A0A1U9NNC1_9BACT  ali  15  29..........................................................................................................GVKAVGYSHRESTRNRARELCIEIADDMNEAVKGADIVILATPIYTF-ERIFKEIASSIKPGAIITDVGSTKVLPHRWGEKIFS-------KDVAYVGSHPIAGSEKSGVDYARDDLTNEEAVKTLVQFWAALGSRVSVMSPAEHDRIFGSVSHLPHVVAVALVNA-----------SNFEQLKYAGGFIDTSRIASGPNVWSDILLSNTSNMIKQLSTIKEAIEKDDQRKLANLLEKAR. 273
357 4.000e-50UniRef50_A0A1G5DAK7 Prephenate dehydrogenase n=1 Tax=Alkaliphilus peptidifermentans DSM 18978 TaxID=1120976 RepID=A0A1G5DAK7_9CLOT  ali  13  4................................................................................FNEITIIGMGLIGGSIGLALKKSGKI-KKITGYDVSKDSLIEAREIGAIIADDLKKAVLMTEVIIIAAPLGQY-ESILKEISPLLNADVIVTDVGSVKGFISSMFQKYL-------PKNIQFIGGHPMAGSEKDGIKLTPSENTTQNTIEKIKTLVTEMKAYPIIVTPQEHDKIVAMISHIPHLTAAMLVISL-SLCDGTKYL-----PFAGGGFRDSTRIASNPEMWKDIFLYNKTEVLRSIENFKYALYTEKEDEILEILGEAKR 278
358 4.000e-50UniRef50_A0A1E5L773 Uncharacterized protein n=4 Tax=Desulfuribacillus TaxID=1543703 RepID=A0A1E5L773_9BACL  ali  14  11.......................................................................................GVGLIGGSIASIKETFPEYEIVGIDTDLSIIHEAISMGVVDWGTIDLNQGVEKADIIFVATPVKA-TEYIIKQLCQALKPDCIVTDVGSTKENIYESAR-------CFQEKSISFIGGHPMAGSEKSGVKYILTPSTPQHAVDVLKNVLESTKAEIIVMSSKVHDEVVGAISHLPHIVASALVNFVREKKDNP-----YYTALAAGGFRDITRIASSVEMWRDIVISNRESMLEILTEIKQAIDVNDIVQIEQFFDTAK. 279
359 5.000e-50UniRef50_A0A135VI46 Uncharacterized protein n=3 Tax=Candidatus Thorarchaeota TaxID=1706441 RepID=A0A135VI46_9ARCH  ali  14  10.......................................................GSGLMGSGIAYVSAWNGYEVTMVDINQELVDQGIESIRNN-------------VLTGIDKGKMSITEAEGLRVKGTVDTEDAVKDADLVIEAIFEMEVKKGVFAKIDAAAPSHAILTNTSSLSIDELAGATKRPD-------KFIGMHYFSP--VPAMKLLEIVIGENSSDETIAVAKAVGEKQGKTTVFA-KNSPGFIVNRLLMPVMRESILMYERGEATKEEIDTAMGPFALGDFVGLDIAYNAMSTLYREIGDCFKPPDTLKNLVDAGDIGMKSK--KGFYDYGAEAAE 288
360 5.000e-50UniRef50_A0A0S8E0V4 Uncharacterized protein n=4 Tax=unclassified Candidatus Omnitrophica TaxID=1047005 RepID=A0A0S8E0V4_9BACT  ali  14  5..................................................................................KVAIIGVGLIGGSLGLAIKK-RKLARLVVGIGRRNSSIRAAKAAIDVGTKDLKKGVSDADLVIIATPVCSI-PRIFKAITGNFKKGAILTEVGSTKAQVVEAIERHL-------PKGISFVGSHPLAGSEKRGVNFARTKKTKTHSIKTLTRFWKSLGARISIKSPEEHDRIVAEISHIPHLVATALINSVG------NKSIKFAST----GFKDATRIAAGDPIWRDICVTNKRQILKS......................... 242
361 5.000e-50UniRef50_A0A1J1J886 CLUMA_CG021289, isoform A n=1 Tax=Clunio marinus TaxID=568069 RepID=A0A1J1J886_9DIPT  ali  16  1.......................................MEISHVTVIGG-------GQMGSGIAQVAAQSGYNVSLVEVNESLLEKAKANIKLSAERLAKKQKEDASKVDEFVSTVIS-------RISGTTDIHTALSKTDIVIEAIVENDAKKKLFSSLDKIAQPKTIFANTSSIPISEIAKSTNRLD-------RFLGLHFFNP--VPMMKLLEVIRIPETSDETYETCMKFGTKLGKTCVTC-KDTLGFIVNRLLGAYTTEAVRMLERDDAKAKDIDYPMGPFELLDYIGLDTTQSVREQNPLY....................................... 263
362 5.000e-50UniRef50_A0A1V4VQI3 Putative 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Pelotomaculum TaxID=191373 RepID=A0A1V4VQI3_9FIRM  ali  15  33.......................................................GAGTMGNGIVQVVAQAGYQVVMRDISDDFLAKGLKTIEKSLSKLVEKNKIKAD------------EKANILGRITTATSMDAVSSADLIIEAVPERDLKVKVFEEIDKLAPAHAILSNTSSLPITAIAAATKRPE-------QVAGIHFMNP--VPMMKGVELIKGRVTSQETLDKAVEFTKSLNKVPIAMDYA--GFISSRLLQAYCNEAAYTVDVDDNMIYCANMPMGPCALMDLIGIDVCVFVM-QICEEEFGPRFKAAPILKQMVNAGHLGRK............... 295
363 5.000e-50UniRef50_A0A2M6Y1K1 Uncharacterized protein n=1 Tax=Elusimicrobia bacterium CG08_land_8_20_14_0_20_44_26 TaxID=2014308 RepID=A0A2M6Y1K1_9BACT  ali  16  21................................................................................................ASLAKKLTSSGFEVICVGRNRKHLLKARTLGVEISTDLSD-LSRCDIVVVSTPV-DVIIEISKKIIPLMKKGAVITDVGSVKSNICARL------SVFAKKCGVSFVGAHPMAGSEKSGCEITPVKETNRNALKVVAEMWEKTGASCLITRPARHDRFAAVASHLPHLISFCFME----MFLDFEKKNGKAKEAAAGSFRDITRVASSPAVWNAIFKENRAFLSKNVK-----VFINKLENMMECLKSRK. 269
364 5.000e-50UniRef50_A0A1I6G3T7 T-protein n=1 Tax=Idiomarina maritima TaxID=519453 RepID=A0A1I6G3T7_9GAMM  ali  12  42..............................VKRKLGQPLY-VPEREAAMLVNRREQA-------AQVGLSP--ELIEDVLRRVIRESYQQQQA---ADVHLETKSVVIFGGAGALGKLFVRLFESAGAAVEKDNWEMAAQADLVLIAVPVVA-TVDVIEAL-PVLPPSCVLADVTSIKQKPLAAMLAKHSGP---------VVGLHPMFGPTLAKQLMVACHGRDEESYQWVLESIQRWGAQIKFIDASEHDQAMSFVQVLRHLSTFVYGAHLAHEKVDVQQLLELSSPIYRLELMMVGRLFAQDHLYADIILSEPHNFVRLFEQLLSELEQGNKAGFIRRFEHIRE 351
365 5.000e-50UniRef50_A0A0F2NKE6 3-hydroxybutyryl-CoA dehydrogenase n=3 Tax=Bacteria TaxID=2 RepID=A0A0F2NKE6_9FIRM  ali  13  1..............................................MEVNKILVVGSGQMGSGIVQVCAEAGLSVYMFDSNRAAMEKGLATVDRFLSRAVEK-------------GKLMADRKKSIMDNITTDLKE-VPDIDLVIEAVVEMEVKQQIHAQLDSVLKPETILASCTSLPISEMGSVTKR-------QNKFVGIHFHNP--VPVMKLVEIIRGMETDDDTYKTAYDFVLKLGKTPVVV-KDVPGFITNRVKIPELVEAIRAYSEGIATAKDIDTPLGPLELCDFIGLDTLLHIMNDLYDNYADTRFFPPPLLKKLVSLGYLGRK............... 274
366 6.000e-50UniRef50_A0A1H8ZWH9 Prephenate dehydrogenase n=4 Tax=Sinobacteraceae TaxID=568386 RepID=A0A1H8ZWH9_9GAMM  ali  14  10.......................................................................................GLGLIGGSLARALRAAGEVG-RISGYDPDPVQRQQALKLGVEVHEQAPEAVADADLVVLAVPVLR-TAEAYAACLPGLRPETVVSDVGSTKQSVLRDIAAVCGGQLPPR-----FVAAHPIAGTEKSGVRVIITPHEHQDAAARVARLWQAIGARVVEMSPAQHDAIFAATSHLPHVLAYSFVDMLARLERSGE-----IFPNAGGGFRDFTRIASSSPMWHDVLRANEAAVLQQIRRMMAESRWDELKALFERARAARE 283
367 6.000e-50UniRef50_A0A2M7UKS3 Prephenate dehydratase n=1 Tax=Candidatus Peregrinibacteria bacterium CG_4_10_14_0_2_um_filter_43_11 TaxID=1974776 RepID=A0A2M7UK  ali  15  14..................................................................................................................MGQQFVRFFEKNGFTVIVSNRQLVEKADVVIVSVP-MDKAESVIHEIAPHVRKSGLLMDFTSLKVCPMQAMKSTKAS----------YLGCHPLFGPTMEGQVVILCPGRGKEWFDWLKNLLSKNRIIVRKLSAKKHDEMMAYVQVLSHFTDITFADALRNSGFKMKDFLNYQSPAYRLKLDMMGRILDQSALYGNIHIQNPDGFLKSAETLSDLVQRKDLKSFENYFKKA.. 249
368 6.000e-50UniRef50_A0A1F2WM86 Uncharacterized protein n=1 Tax=Actinobacteria bacterium RBG_13_55_18 TaxID=1797197 RepID=A0A1F2WM86_9ACTN  ali  15  1..............................................MEMKKVFVVGCGFMGSGIAQVAAAAGYRVKMCDLDQERTSAGLRAIESSLDKLLAK-----------DKIDIKQRDSALANIGTTTELQDA-GDADIVIEAIFENDIKRETFEKLDGICPPHAILTNTSAIPVSSIAAATSRPD-------RVVGIHFFGP--VPLMRLVEVIRGLLTSNETLEIADEWARSLGKETVIVLKDHAGFVANRGSIPSTIEAIRMVDEGLATPEDIDRAVGPMQIMDNAGLDVGLNAAMAIYEDTRDTKFFPPPLLRRLVSAGLLGRK............... 274
369 7.000e-50UniRef50_B6BUD8 Prephenate dehydrogenase n=2 Tax=OM43 clade TaxID=1233498 RepID=B6BUD8_9PROT  ali  13  23.......................................................................................................KNLTKQVVGFGRNSESLKKAKQLGVHEISESFEDLNQADLIIIATPVKQYS-TIFKKINQFLSPTTLITDVGSTKKNVINDASCFLDDHYAK------FIGSHPIAGSEKHGPEIIITPHNTKEDIDFISNFWNSLEGTSLIMDAVSHDEIFSTVSHLPHALAMIFMSML-NGKNNKDELLRFA----ASGFRDFTRIASSPEMWKDIFIDNKEACLKDLNEFKKQIEKEDLEKYLQY...... 271
370 8.000e-50UniRef50_A0A2D7RRL9 Cyclohexadienyl dehydrogenase n=7 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A2D7RRL9_9PROT  ali  13  16.............................................................................................SILRSLNNHKITDKISVFDKSKDVQSFLKKEKLSDNISNDLVKSVRGADLVIISSPLSSYK-EILLSIKDHLDADTILSDTGSVK-------KEVDKIVFNLGMKDVSWIGSHPIAGTEQSGPSAILSPTHNKEHLSRLKFFWESLGCKVKVMSSEEHDQILSLTSHLPHAIAYNLVVTAFKDNESFEEIIKYS----AGGLRDFTRIASSDPMWKDIFIDNSDNILKVLDSFSKNIEEKNSEKLLKIFSSTK. 278
371 8.000e-50UniRef50_A0A149VVB5 Ketol-acid reductoisomerase n=2 Tax=Ferrovum TaxID=416212 RepID=A0A149VVB5_9PROT  ali  14  10.................................................................................RRIAIIGVGLIGGSFA-LAMREAARDISIVGYDRDEVNLAAAKQLGVSVVHSLSAAVKDADVIQIAVPVGQIEP-VLNEIARHISPTAIITDVGSTKANVIEAAKKSLGTAVQR------FVPVHPIAGAEHSGVVMIETEFTDSLPFEIIKRCWQACGANIETMSVNRHDSVFGVVSHLPHILSFTLV-YDIATRVDAETFFHFA----ASGFRDFTRIAGSNPMWKDITLANKSTLLLELQRYQDLLRYEAIENFFKIARDARR 288
372 8.000e-50UniRef50_A0A2E9REP3 Uncharacterized protein (Fragment) n=1 Tax=Acidiferrobacteraceae bacterium TaxID=2024893 RepID=A0A2E9REP3_9GAMM  ali  12  9.......................................................................................GVGLIGGSVAKALRCENAVG-HVTGFGRRESTLQRAQALGVSWSLDLDAAVERAEVVXLASPVNSIA-SIFHELKPCLGEATIVTDAGSVKGSIVDAA------VRGLGDKIVNFVPGHPIAGKEXSGHRTILTPNTGTEAISAVKDMWETIGAEVVFMEPSVHDELLALTXHLPHALAFILVDLLSRQTNSXD-----CFNLSAGGFYDITRVASGDPMWRDIFLSNKQAILQRLDDLAELIGRSDSSALEEMFKHANR 278
373 9.000e-50UniRef50_A0A2B2CE80 3-hydroxybutyryl-CoA dehydrogenase n=80 Tax=Bacteria TaxID=2 RepID=A0A2B2CE80_9BACI  ali  16  6....................................................VVVGSGVMGRGIAYVGAVGGYSVTLVDVNEAALENAKKELNSIFEK-------------GLSRGKISAETVEKRNLYYATNLQEAASEADLVIEAVPEAEIKKAVFETIEKYAPAHCFFTNTSTMSPTEIASYGNRTE-------KTIAMHFFNPVH--KMPLVEIIRGLETSDETAQVIKEVAEKMGKETVVIN-EFPGFVTSRISALVGNEAFYMLEIDKAIKLGLNYPMGPFELVDLVGLD--ARLNNLKYLEKLGEKYRPAPLLEQYVKAGRLGRK............... 273
374 9.000e-50UniRef50_UPI0006A21CFC prephenate dehydrogenase n=1 Tax=Thermoactinomyces TaxID=2023 RepID=UPI0006A21CFC  ali  15  3.................................................................................EKIAILGIGLIGGSLALGLKERTDAVVVGYDRSEKDLRYAMAIGAVDDWTTSLPQAVSNADMVVIALPVGQIK-QMIETLAELLKPSCIVTDVGSTKSEIMEASRKLKE-------KGIVFIGGHPMAGSHQSGIQYVLTP--DPEAVQKISQLLKATRAELVIMNAAHHDRIVGAISHLPHIIAAGLVNVVGNYNEENEW----FHRLAAGGFRDLTRIGASHPMWRDILLSNRNALLKLM------------DDWIEKMEEVR. 259
375 9.000e-50UniRef50_A0A2V7I5F8 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=3 Tax=Candidatus Rokubacteria bacterium TaxID=2053607 RepID=A0A  ali  15  112...................................................................................................AARAEGLAREIVAVGRRRESLEPALHDGARITTDVAEGVAGSDFCILATPVATLA-SLLDEVWRAAPDDAVLTDVGSTKSHIVSAAEAL------GRARPLAFIGGHPMAGSERSGYPVILTPTASGSALARVREFWEALGARVMTLDPATHDRAVAAISHLPHLVADALVDAVLRMDPRFLD-------VAAAGFKDTTRVAASNPVWREIFQDNREALAEALDDLDRLVAAGDATAIERELERIKR 368
376 1.000e-49UniRef50_A0A2D6WMG6 Uncharacterized protein n=1 Tax=Puniceicoccaceae bacterium TaxID=2026784 RepID=A0A2D6WMG6_9BACT  ali  14  23......................................................................................................EHKLTQTVHVWARNEAKRKLCSELCTHVHASLIDAVKDSDLILLCTPVDTMVP-LLESIAPHLKAGALVSDVGSVKNSICQGAEQVAKGST------LNFIGSHPMAGSEKGGMELTPTEQTDLMHLNLLEDFWSQLEMHTSCMSPQDHDSLIARISHLPHIVASLLAASLDEMSED-------AFRHAGGGLKDTTRIAGGNPLWQSILAENTEAVLRSLESLKSSIETKDFDHLNHILKRGQR 276
377 1.000e-49UniRef50_A0A1F8XGT8 Uncharacterized protein n=4 Tax=unclassified Deltaproteobacteria (miscellaneous) TaxID=122706 RepID=A0A1F8XGT8_9DELT  ali  13  24.....................................................................................................KGKRGAPEVWGCDHRKETVRRALSAGAIARGCTEAELAACDVVVVCIPVLRAVEAI-RRLGPRMRPGAVLTDAGSVKSGIVREGE-------RAAARGAFFVGGHPIAGTEASGFIVTPTRRTDAGAIRRVERIWKRAGAVLLRMDPKTHDHVFAYVSHLPHAVAYALVHSVATLPSKV--PLGYS----AGGFRDFTRIASSNPMWKDIVLQNRTEVLRALRNLALLERRGDVDGLLEYFGRAKK 277
378 1.000e-49UniRef50_A0A2E6A8T0 Uncharacterized protein n=9 Tax=unclassified Gammaproteobacteria (miscellaneous) TaxID=33811 RepID=A0A2E6A8T0_9GAMM  ali  14  1...............................................................................MFDTVAIVGVGMIGGSVAAAL-RQRGLTGRIHGYDASAEHLDAALSAGLI--DDAPAGPAAGDLIVLAVPVLSVT-QVLGELAPAFSAGSVVTDVLSVKQPVLDAAVRSLGRVPGT------LVPGHPIAGSERRGHRVILTPTSDDSATVTVQRMWEALGAEVVLMDAERHDRVLACTSHLPHLLAYALVDSLSRL-DDSAEVFRFS----AGGFRDFTRIAGSDPMWRDIFASNRTALLGVLDRFSALIERDEHEGVFEVLEKAR. 273
379 1.000e-49UniRef50_A0A2H5ZVF3 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=bacterium HR32 TaxID=2035427 RepID=A0A2H5ZVF3_9BACT  ali  11  205.........................................................GLMGSGIAETCARQGYEVVVREVNDELLERGLRRVQQSMARAVER-----------GKLPPEERDAAWVRIRGTVRM-DDLRDCDLVIEAAVEMDVKKEIWRELDRICPERTLFCNTSSLSITEQASVTRR-------GDRFCGLHFFNP--VPVMKLVELVRGLQTSEETLDTCRRFAESLGKTVV-VAKDYPGFIVNLLLVPFLLDAVRALEKGLATKEDIDHPMGPFELLDFVGIDTTYYIAEAMFQEFKDPRYAPPVLLKQM........................ 458
380 1.000e-49UniRef50_A6GGV0 Prephenate dehydrogenase n=4 Tax=Bacteria TaxID=2 RepID=A6GGV0_9DELT  ali  15  116.....................................................................................................ASRRVAIIGGEGSMGRQFARAFESLGNEVSLRPAEAVADAQVVLFAVPIAQ-TERIIAELAPLARPDALLTDITSVKAGPVAAMREHGEAT---------VIGTHPLFGPSMQGQRIVLTPAWDADWLPWLETSLRAMGLELVRSTPAGHDRAMAIVQVLTHYSTEVLGRSLQRLGVSLEETLRFTSPIYYIDMLMAARHFAQSELYASIQTQNPAVFREVAEELAGIISAKDGDAFSEVFDEVRE 378
381 1.000e-49UniRef50_D3SLX3 Prephenate dehydrogenase n=1 Tax=Thermocrinis albus (strain DSM 14484 / JCM 11386 / HI 11/12) TaxID=638303 RepID=D3SLX3_THEAH  ali  10  1...............................................................................MFERVAIIGFGFMGGSLAMAIR--DVYSCRIMGIDRSHQALQTAKKMGLEGSTQIEDIASDPQLVVLATPVRAY-YEIAPRLVHVVSPQCVITDIGSVKGRLVFFLEDVLGPR---------FVGGHPIAGTEKSGVEITPTPNTSQESLRWVEQLWKGIGSHVEFMDPYLHDLIFGAVSHLPHAVAFALVKAVLRMSQEEKVDM----LLYAGGFKDFTRIAASDPMWRDIFTENKEYLLKAL-----TVFKDSLEDLRKMIEEEK. 264
382 1.000e-49UniRef50_G8TWG5 Uncharacterized protein n=39 Tax=cellular organisms TaxID=131567 RepID=G8TWG5_SULAD  ali  10  10.......................................................GAGTMGHGISQVAAQHGYEVLMWDAAPGVVERAIGIIGDRLAK----------QVAAGKLPESERQQTLKRLVPVTR--WDDLASASLAIEAVEVMEVKKEVFQELDRVLPADALLTNTSSLSITEIAKVTRRPGQVL-------GMHFFNPA--PVMKLVELVRGEETRDDVVQRAETFAHSIGKETVVVQKDTPGFIVNRVLMPLFIEAMRILEEGIASAEDIDHPMGPLTLADLTGLDVDLHVMDYLYDEFHDDRFAAPMVLRRLVRAGHYGRK............... 275
383 1.000e-49UniRef50_F5SLQ0 Prephenate dehydrogenase (Fragment) n=1 Tax=Desmospora sp. 8437 TaxID=997346 RepID=F5SLQ0_9BACL  ali  14  1............................................................................................................EVHGFDASKESLTLAKAAGVEGHMRLESAVEDADVIFLAVPVGS-TPRLLNRLATLLKRGCIITDVGSTKGEIVRYAE------GLDNLRGI-FIGGHPMAGSHRSGVVLTPLPETPLPEVQRLSRLLEATRARLVIMNPEHHDRVVGAISHLPHIVAASLVNQVA----DYNASNEWFHRLAAGGFRDLTRVAASHPMWRDILLSNRESVLALLEDW-----TREMEGIRRAVKDGD. 239
384 1.000e-49UniRef50_B3PII3 Prephenate dehydrogenase n=39 Tax=Gammaproteobacteria TaxID=1236 RepID=B3PII3_CELJU  ali  12  8..................................................................................KFVVVGIGLIGGSLATGL-KQRGACREVIGISRTPQSCADAISHGVRAYTSLREVASEGDIIFIAVPTLAVT-AVLKEIQEVIDPAVTLTDGASVKGSVQKAAESVFGKVP------AQFILGHPIAGSEKSGVRVILTPLSSPEHLQQVTAMWQAVGAEVLSMSVEEHDQVLGATSHLPHVIAYSLVDTLAQ---DIGNPNIF--RYAAGGFRDFTRIASSDPMWHDIMRANKAAILASMDRLRASIEHEDSEQLLRVFSRAKE 285
385 1.000e-49UniRef50_A0A202DR62 Uncharacterized protein n=1 Tax=bacterium F11 TaxID=1932698 RepID=A0A202DR62_9BACT  ali  12  8.......................................................................................GVGLIGGSLGQALRSKRRSGKRVSGCGRSTRRLKNAKRLKAEYSLSMKVLIPKADIIVLCVPV-QFMAKTMREILPYLKSGAIVTDVGSVKQKIIIEAKRILGR-----RKDVFFVGAHPIAGSEKSGVIYSRPDLFSPRAFRTIRKMWEQVGAICTSLTAKKHDEIMALVSHLPHFLSFALLSLVEKEARKNSRILSLVGRS----FRDMTRVGRSDPLWKGIFRENRFSVKRSLMRFHRILKTLRIQLLRD....... 268
386 1.000e-49UniRef50_UPI000B98A9E0 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Clostridiales bacterium SK-Y3 TaxID=1792311 RepID=UPI0  ali  13  10.......................................................................................GLGLIGGSIAKALKERSGI-KNIIGIDFNQDTLTQALNEGIIGSKDIVPEIYNSDIVFICTPVSK-TLEWIKKVIPAVRPDCIITDVGSTKSQLVSEIEQIPGEF--------HFVGGHPMAGSERSGYILTPCSKSTQEDIEILINVVKNLGSIPVELSPQLHDKVTGAISHVPHIISAALVNIVKNSDTDG----QYMQKLAAGGFKDITRISSSNPMWHNICFSNKDAIIQILDNFKLFLESRNDNEVYNFFSSAKE 278
387 1.000e-49UniRef50_A0A087S1A8 3-hydroxybutyryl-CoA dehydrogenase protein n=25 Tax=TACK group TaxID=1783275 RepID=A0A087S1A8_9ARCH  ali  14  1..............................................MTIKNITVLGSGVMGHGIAQVSATAGYNIVLRDIEQGFLDKAMEKIRWSLDKLVSKEKISKEEG-----------DAIFGRIKPVVDLKEAVKDAELVIEVVPIMDLKKKVYAELDEVAAPEVIFANTSTLPITEIANTTSRPD-------KFIGIHFFNPPQL--MKLVEVIPGEKTSKEITEITKDYVKSVNKQAVLCRKDVPGFIINR-LFIPMVTGATLEEIDSAVKFKLGFPMGIFELADFTGMDVIHKATVEMHL-RDKKVINPHPLVEKMDEKKLGQKSGE............. 278
388 1.000e-49UniRef50_A0A2E5J389 Prephenate dehydrogenase n=1 Tax=Chloroflexi bacterium TaxID=2026724 RepID=A0A2E5J389_9CHLR  ali  12  8.......................................................................................GLGLIGTSIGMALRKA-KVNVEVIGHDRDRGSANQAQKMGAKNEWNLISAVEDAMIVIIATPVKTI-EDVMQQIAPVLKEGCIVTDTGSTKATVLQWASKHL-------PPHVQFIGGHPMAGKETSGPHILPGKGSNAQSAQTIVEMAEIIGAVPYFLDPVEHDSYVAAISHLPMLLSSVLVKITSDSPAWPE-----MARLASTGYRDISRLASQDPMNRDICLTNPDGVVYWIDEFI-----KEIYRFRGLIKDGDD 264
389 1.000e-49UniRef50_A0A127AP40 Chorismate mutase n=3 Tax=Deltaproteobacteria TaxID=28221 RepID=A0A127AP40_9DELT  ali  14  1..................................................................................................................MGQWFEAFFEKRGYEVPLSNKELVQKSDVVIISVPI-RVTVEIIKEVGPYIAPEALLMDFTSLKKASVEAMLKYSKS---------EVMGAHPLFGPSLKGQTIILCPARGESWLPWLKEVFKE--AYLEITTPEKHDQIMAVIQALTHFFLLGFALILKESPFSMETLMRYATPNFQI---ISQRIFQNPEIYASIQFDNPEKILEVLERLKKIIQDQNYEEFLKIFQE... 236
390 1.000e-49UniRef50_UPI000D3E2139 prephenate dehydrogenase/arogenate dehydrogenase family protein n=4 Tax=Burkholderiaceae TaxID=119060 RepID=UPI000D3E2139  ali  12  49..................................................................................................LALKHHQISSKVLGCGRSRPNMEEALRLGISEIASLQELGEQADLIILCVPVAQ-TKSVLMQLVPFLRKETLLIDVGSTKSDVIAIAKEVLG------EQVGQFIPCHPIAGGAQHGRQLIICPLNTPQAILLIKQMWQQLGSVVFQMSALMHDHIFAAVSHLPHLLSYALMLQVANSE---DAQAKFAH--AGAGFRDFTRIASSPEMWRDISFANSEAILSQLDE-----YVNILQHFKKLIQDGN. 294
391 1.000e-49UniRef50_UPI000B9259C5 probable 3-hydroxyacyl-CoA dehydrogenase B0272.3 isoform X1 n=2 Tax=Pieris rapae TaxID=64459 RepID=UPI000B9259C5  ali  14  27.......................................................GGGLMGSGIAQIAAQAGQNVSLVDLNSEALQKALKSIENNLTRVAKKVHK--DDVAKIN----SFVKDSLARIKTSVKIEDGI-NSDLIIEAIVEQDVKQQLFNKLDELAPQHTILTNTSSIPISAIGSGIKRKDRLG-------GLHFFNP--VPVMRLIEVIKSDGMSEETHQTLMEWGKSVGKTCITC-KDTPGFVVNRLLGPYSAEALRMYERGDATMEDIDYPMGPFELCDYTGLDTNKHVMRVLYETTKDEVFRPVPLLDKMVEGKLGVKSG--EGFYKY...... 304
392 1.000e-49UniRef50_A0A1I5QW74 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Oscillibacter sp. PC13 TaxID=1855299 RepID=A0A1I5QW74_9FIRM  ali  15  7.......................................................GAGTMGSGIAQVFAAKGHTVYLYASSPASAQTHKEKLEASLAK-------------RVAKGKMTQEAVEELLKRILIEEEAACADADVMIECIKEDEMKRSLFSRLEKMAKPEAILTNTSSLSLAEIAAGMEEPSRL-------VGIHFFNP--VPAMKLVEIVRTRMVQPEIVSRAKEIVESLGKTTI-MAPDSPGFVVNYLQYPFRLNAMRMLENGVATAEDIDHPMGPLELQDMVGLDVTYYATSSIYERTGDPAMKPPKILKDMVEAGLLGRK............... 270
393 1.000e-49UniRef50_A0A2M7ADU0 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Armatimonadetes bacterium CG07_land_8_20_14_0_80_40_9 Tax  ali  13  25.....................................................................................................KKKGLARKVIALALSRETIKEGKERGAEGTLSLKKGVKSADLLFIAVPTGSIVK-MIKKSLPYLKEGCIITDVGSTKFDIVKEVE-------GFLPKRFSFIGGHPLAGSEESGIKYVLTPQAKADSSSLSLLKIKGIGAKVLILSPEVHDALLARTSHLPHLLATSLVNTVEDLGKRERKTFKVLTP----GFKDTTRIASSSALWQDICLSNQRQILKALSEFKENIKEKDLAALGKQLNRANR 281
394 1.000e-49UniRef50_A0A269W5H8 Prephenate dehydrogenase n=2 Tax=Paenibacillaceae TaxID=186822 RepID=A0A269W5H8_9BACL  ali  14  9.......................................................................................GVGLIGGSLALCFKGKPGITVTGYAHTEEYAAQVIAKGVVDHVTLSAAEAAQDADVIFLCVPVGSL-ESYIQLLSEMLKPGCIITDVGSTKASITACASAL-------ALKDACFIGGHPMAGSERSGVYYVLTPDVPDDKLQKLIDLLAHTRAHIVQVEPRLHDQIVGAISHLPHIIAVALVNQIRTYNDD----NPLYRMLAAGGFRDITRIASSDPLWRDILLNNRDVLLPLLRDW-----NEEIQGFIAMLENNS. 265
395 1.000e-49UniRef50_A0A1W1V706 Prephenate dehydrogenase n=1 Tax=Desulfonispora thiosulfatigenes DSM 11270 TaxID=656914 RepID=A0A1W1V706_DESTI  ali  17  12.......................................................................................GLIGGSWGLA-LKRTCPEIIITGVDLDKNSLNQGLELGVIDNISTSLAKGVKDADVVIIST-LASSVIKVINEIIPFLKKGAIVTDTASTKQNIVEGIKKSL-------PDDIFYIGGHPMAGSEKQGVVYVLAKETNKEALNSLVSLITKVGSKVLFLKAAEHDQKVAAISHLPHLVAAVLMNTVGTLE---NQKSGFFQL-AAGGFRDVTRIADSHPMWKDIFMENKETFRKSLDEAENAIINENENNLLEYLSSAKK 279
396 1.000e-49UniRef50_A0A101VAN4 Uncharacterized protein n=3 Tax=Clostridiales TaxID=186802 RepID=A0A101VAN4_9FIRM  ali  16  12.......................................................................................GLGLIGGSFALALKRVRP-EISIAGYDLDEHTLLKGEQSGIIYSLKIDDAVKESDLIVIACSLSQTVPMALKAI-PHLKAGAILTDVGSVKETIVTKIEEVL-------PANIHYIPGHPMAGSEKKGLDYILTPTTSQNGLNTLLDIIKALGARPLIMSPSEHDHQVAAVSHLPHLLATSLVNAAGIVKDKYPDLL----LLAAGGFRDTTRIASQPEMWKDICLNNRKAILEVLE....................... 251
397 2.000e-49UniRef50_D3S1I0 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Ferroglobus placidus TaxID=54261 RepID=D3S1I0_FERPA  ali  16  10.......................................................GAGTMGHGIAQVAAMHGYDVVMVDIKQEIIDSAFEKIKASLNKLAEKGKFDANKIDDVLE-----------RIKGTTKLEDA-KNSDFVIESVPVMEIKQDVFRKLDEICHREAIFTNTSALSITEMASVTKRKD-------KFAGMHWFNPPQI--MKLIEVIKTIDTSEETLNTVVNLAKEFGKEVVIC-KDSVGFIVSRALQAFVTECIRILEEGVASAEDIDHPMGPFELLDFT...................................................... 235
398 2.000e-49UniRef50_T1IXS0 Uncharacterized protein n=2 Tax=Ecdysozoa TaxID=1206794 RepID=T1IXS0_STRMM  ali  13  11........................................CLSTSPIVQNVIVVIGSGLMGSGIAQVAAQSGHQVVIVDISDDILKKAHVAIKTSVQRVAKKQF------AADTKKADSFVSDTLSRLVTNTSPERAVLNADVVIEAIVENDIKRKLFQSLEKIAPPNAIFANTSSIPIGDIAAAVTS-----NRKQHFAGIHFFNP--VPIMKLVEVIRIPETNDDTYNKLVSFSRALGKEPVTC-KDTPGEATAK-------------DIDTAMKLGAGYPMGPIELLDYVGLDTTKFILDGW.......................................... 253
399 2.000e-49UniRef50_A0A117KYY6 Prephenate dehydrogenase n=1 Tax=bacterium 42_11 TaxID=1635281 RepID=A0A117KYY6_9BACT  ali  13  7.......................................................................................GVGLMGGSLGMALRK--RLGAFVVGVVRKEETGIKALELGARWTLSLEEGVKDVDYVFFATPVKSIGP-LFRRAQPHIREGALISDLGSTKRNVVKDITSIL-------RKDLAFIGGHPMTGSEKRGVEYILTPLFDRGRVGELIDLVKGIGAKPYILEPEKHDLIVALISHLPYLLSIALVELVSRDET--------AQELVAGNFRDLTRPALSDPMWRDIISDNRDFIKKRLEELIEIIDKDDVEK-ERFFEKVRE 267
400 2.000e-49UniRef50_A0A075MSF2 3-hydroxyacyl-CoA dehydrogenase n=62 Tax=root TaxID=1 RepID=A0A075MSF2_9ARCH  ali  12  2.............................................SVSINKITVLGSGVMGHGIAQVSAMAGYNVTLRDIEQSFLDKAMEKIRWSLNKLVEKQ-------------KLSQQDADKIFARITVDLKTALKGADLLIEAVPEMNLKKKVYAEVDSFAEDKTLYANTSTLPITDMAALTSRPE-------RFIGLHFFNPPQL--MPLVEVIPGAKSNAGMVDMAMDYCKKVGKQPVLCKKDVPGFIVNRVFILVHEAVYSMTQIDSAVKFRMSFPMGIFELADYTGLDVIHKATVEMHM-RDAKVIFPHPKIKQLDEKNLGQKTG--KGFYEY--KGDK 289
401 2.000e-49UniRef50_A0A2E9CDY1 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Candidatus Heimdallarchaeota archaeon TaxID=2026747 RepID=A0A2E9CDY1_9ARCH  ali  13  41.......................................................GSGQMGAGIGLVCAIHDYNVVFYDVKEEFVNNGIERNKKWIKRQVEK-------------NKLSKENAELIKMSGTISLEAAVSNSDLIIEAIIENDIKKELWAKVANFAPEHTIFSNTSSLSISEMAKASKRPS-------KFLGTHFFNPPVI--LKLIEFIQTTHTSEETMNIAIQFGQTLGMDTVKA-KETPGFIVNRLLIPQLNEAYLLLENDIATKEDIDHPMGPLTLSDFIGLDTILYIAEYLHKHLG-PKYKPANILYDLVNQGKMGRK............... 305
402 2.000e-49UniRef50_A0A1W6NXT4 Cyclohexadieny/prephenate dehydrogenase n=178 Tax=Bacteria TaxID=2 RepID=A0A1W6NXT4_9RHOB  ali  13  32............................................................................................................TIVGYDIAPETRAVARELCDQVVDSAVDAVADADLVILCVPTGAMDV-VAAEIASALKPGAILSDVGSTKRSVVDAV-------APFVPDGVHFIPAHPLAGTEHSGPRIVPLPDSDPVALDKLKAFWQALGANVDVMDADHHDRVLAVTSHTPHLIAYTMVGVADDLGRVTDEVIKYS----AAGFRDFTRIAASDPMWRDVFLNNKDATLEILGRFTEAIRMGDGDHLHAYFTRTR. 281
403 2.000e-49UniRef50_A0A2D5HJ06 Cyclohexadienyl dehydrogenase n=3 Tax=unclassified Alphaproteobacteria TaxID=82117 RepID=A0A2D5HJ06_9PROT  ali  12  14.......................................................................................GGGLIGTSLS-LSIKKNNLCDVIKVYDSNIQVRKKLKERLNEIYESLEETVFDADLVVLCIPVGSMK-EVAKSISKLLKDGCILTDTGSTKNSVIKDVK-------PYISQNIWFIPSHPLAGTENSGPEIVPYYSIPNEVMDNFSKFLSGSGAITEIMKPEYHDKILAITSHLPHLIAYTIVGTATDLEDQTKDVVRFS----ATGFRDFTRIASSDPMWRDVFLNNKGAVLEMLQRFTEAIRWAEGDKLEDLFTKTRE 284
404 2.000e-49UniRef50_A0A263BWR6 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Bacillus sp. SA5d-4 TaxID=1904753 RepID=A0A263BWR6_9BACI  ali  15  9.......................................................GSGVMGRGIAYVSAVGGFNVHLVDIKEEQLKTAEAEINAIFDK-------------GLSRGKISESKAAKERLSYTTNLVSVVEEADLVIEAVPEKEIKKAVFEQVDAHAKEGCLFTNTSTMSPTEIGSFTKRPD-------QVIAMHFFNPVH--KMPLVEIVRGLETSDATADAIRQVAEKMGKETVVVN-EFPGFVTSRISALVGNEAFYMLEIDKAIKLGLNYPMGPFELVDLVGLD--ARLNNLKYLEKLGDKYRPAPLLEKYVKAGRLGRK............... 273
405 2.000e-49UniRef50_A0A101GAI9 Prephenate dehydrogenase n=5 Tax=Bacteria TaxID=2 RepID=A0A101GAI9_9BACT  ali  14  6.............................................................................DFSFNKISIIGVGLIGGSLGLALKEKNPNFKIVGIDKQEIIEKAITRGAIDEGTVNIEEGIKEADIIIIATPVKTI-LNILTLINPFLEKGCIVTDTGSTKQQIVQKADKVLS-------KDIFFVGGHPMAGLEKCGITYILTPTSNLRALEKISLLIKMIDAKKLILDPLEHDRIVSAVSHLPQIIAVSLINAIGELALRGNNNSYF--KAIGEGFKDMTRIASSPYMWEDICETNQENILEMIQEFKENKLKNNPNSLKEEFQKARK 285
406 2.000e-49UniRef50_C8W3C8 Prephenate dehydrogenase n=4 Tax=Desulfotomaculum TaxID=1562 RepID=C8W3C8_DESAS  ali  12  28...........................................................................................................VKITGIDLDKENLRLALELGAETTVSLEEGVRAAELVILAAPVAQSVI-LLERMLPYLSAGTVITDVGSTKMEITARAAALL-------PGDIYFVGGHPMAGSEISGVLLTINEDTDVAALSKVKYMVSLLGARTVELAPEEHDQSVAVISHLPHLVAYTLVNTLAALPG-----WESILPLAAGGFKDTTRIAMSNAMWRDIFLSNREKVLQVLADFNM-----QLALFKEAVEKSDD 265
407 2.000e-49UniRef50_A0A1A8THE1 3-phosphoshikimate 1-carboxyvinyltransferase n=27 Tax=Oceanospirillaceae TaxID=135620 RepID=A0A1A8THE1_9GAMM  ali  12  26..................................................................................NVLVVGLGMIGGSFAKALKERGLATLYGADRRESELVLGVSSGVIDHPAMLSSEFIAKMDVIVLATPVRAM-ESVLSEIKPYLKPTTLLTDVGSTKGSVVEAAKQVFGDMP------ANFIPGHPIAGAEKSGVIVTPLPVSNPVLVDRLHQLWMAIGADVVSMDVEHHDYVLASSSHLPHLLAYTLVDALANSDRSQD-VFKFA----AGGFRDFTRIASSDPMWRDVFLSNKKATLATLDHF-----TERLAVMREAVEQGD. 286
408 2.000e-49UniRef50_A0A1F9X031 Uncharacterized protein n=5 Tax=unclassified Elusimicrobia TaxID=1797919 RepID=A0A1F9X031_9BACT  ali  17  5..................................................................................KVAIIGVGLIGGSIGLALKRNFKFKIRIIGIGRHIEKLKLAKKFGAEFTTDFKSGVKDADIVVLASTVDTIVP-IFKNIAPYLKPGCIVTDAGSIKAGIVNRISKIL-------PKSVHFVGAHPLAGSEKTGVRIVITPLTPLASIKTISGMWKKMGGRVIMLSPEVHDNLVARTSHLPHILSAALTKIVN----NINSKNKAASKLLAGSFKDMTRITDSDENWAAICFGN------------MLELNKAINEYIEILKKVK. 268
409 3.000e-49UniRef50_A0A2E5K252 Prephenate dehydrogenase n=1 Tax=Opitutaceae bacterium TaxID=2006848 RepID=A0A2E5K252_9BACT  ali  15  36.....................................................................................................KENRMAERVHIWSRRANSRAKLKQWCDEIFDSPKGAAAQADLIVICAPVDYIVP-LYKEIGPILKTGAIVTDVGSTKSIICRQAQSIQET-------GAHFIGAHPMAGSEKTGCIIAPLEESNELATQRTVQFWKSLGAITYIKTPEDHDEIVAHVSHLPHLLASSLCKFLDQKPED-------WGLLSSXGFKDTTRIAAGDPLWKAILETNHXEIRRALSEYQDALTNGDLAELFAVLQQGKQ 289
410 3.000e-49UniRef50_C5TNF5 Prephenate dehydrogenase n=171 Tax=Betaproteobacteria TaxID=28216 RepID=C5TNF5_NEIFL  ali  13  27.....................................................................................................KRLGLVQTVTGIDTNADNLNYALECGIHAYPNIAESISNADLVLIATPVS-VLPDVCRDIKPFLKDTACVSDVGSTKQSALNAFRTHLSDRLPQCFA------AHPIAGSDQSGAKLIITPHGQEASLRRLKSLWQAVGSQISTMSAEEHDNIFAAVSHLPHLAAFAYVHALVDHPHGKDYL-----PYAATGFRDFTRIASSPAVWTDICMANRPALLKLTSDL-----KEQLSKLEQLLSDGNK 272
411 3.000e-49UniRef50_Q3SK84 3-phosphoshikimate 1-carboxyvinyltransferase/prephenate dehydrogenase n=18 Tax=Betaproteobacteria TaxID=28216 RepID=Q3SK84_THIDA  ali  13  2...............................................................................IVERLAVIGVGLIGGSFA-LALKQAGAVGEVVGVGRKPASVEQARARGLIDRAGDWSEAGQADCVLLAMPVGE-TETVLRALEPHLTARTIVTDAGSTKSGVVATARAALGAKWR------NFVPGHPIAGSEQSGPKVVLTPDTDPHALAIVKALWQAVGAEPELLDAATHDRVFAAVSHLPHLAAYALVDEL-AQRADRDTFFRFA----ASGFRDFTRIASSPEMWRDIALANRDALLAALQTLSTAVAAADGTALLEIFSRARD 277
412 3.000e-49UniRef50_A0A212EV03 3-hydroxyacyl-CoA dehydrogenase n=2 Tax=Neoptera TaxID=33340 RepID=A0A212EV03_DANPL  ali  13  11.........................................FSHSASLNATVTVVGGGLMGSGIAQ-ATQAGQNVTIVDLNSEILEKAQKSIQNNLGRVARKLYK-----DDPLKMEEFVKEA-NSRIKVSTKIEDGV-DADLIVEAIVELEPKQKLFNRLDELAPEHTILANTSSISINEIGSGIKRKD-------RFGGLHFFNP--VPVMRLLEVIKSDRMSQETYNAMMEWGKSVGKTCITC-KDTPGFVVNRLLGPYSAEAFRMFERGDASKEDIDYPMGPLELADYTGLDTNKFVLEVLYQKTKNQVFKPIPLLKMVEEGKLGIKTGE............. 298
413 3.000e-49UniRef50_A0A1W9T869 Uncharacterized protein n=1 Tax=Planctomycetales bacterium 4572_13 TaxID=1971638 RepID=A0A1W9T869_9BACT  ali  16  21..................................................................................................LSAKRALARSRIVGYSHRDSTRQKAREVADEIADSLEAAVEGADVVILATPIQTF-EDYFKQITPYLKDGCIVTDVGSTKTLPHKWAAEHL-------PRGV-YVGSHPIAGSEKRGVEYARDDGTSAAAIEVLDGFWSKLGCNTEVMSPANHDRIFGMISHLPHMTAAALVNSVSQQN------IKFAGR----GFIDTTRVASGPNVWTDILMTNSETLVGQLQTLQAAIAAGDAQKVNKILAQASQ 273
414 3.000e-49UniRef50_A0A2E8CK63 Prephenate dehydrogenase n=1 Tax=Acidiferrobacteraceae bacterium TaxID=2024893 RepID=A0A2E8CK63_9GAMM  ali  15  28.....................................................................................................KQAGVVDSVLGCGRNASNLDKARELGLSWTHDPVEAASAADIVLLAAPVSAVI-DLLPLMREGLRPDAILTDASSVKVDIVSAARAGLGARLSR------FVPGHPVAGSEKGGAEAILTPLTDLDALDRVERLWRETGARVRCMNEGTHDRVLGMISHLPHLVAYALMAQLDAQS-DPEDCKALA----AGGFYDISRIASSDPMWRDISLHNRPILLSQLESLVCAGDGERLETWFTRAREVR. 286
415 3.000e-49UniRef50_A0A075I6L7 3-hydroxybutyryl-CoA dehydrogenase (PaaH, hbd, fadB, mmgB) n=83 Tax=cellular organisms TaxID=131567 RepID=A0A075I6L7_9EURY  ali  14  10.......................................................GAGTMGAGIAQVCAQTGWKTRLYDAFPEGLTKGMDAIEAFWDK-------------GIERGKTTSDQKAEWNLRGVNDLTEAVEDADLIIEAVPEMQLKQEIFAELERLAPSHAMLTNTSGLPISEIAQSTGCPD-------RVIGMHFFNP--VPLMSLLELVRHNAVSEETIAAAQSIGSAMGKTTILVR-DVPGFATSRLGVVLGNEAVRMLAEGVASANDIDHPMGPLELSDLVGLDVRRDILNNLADAFDDESYRPHPLLGQLVEAGNLGKK............... 275
416 3.000e-49UniRef50_A0A2E2B1D9 Prephenate dehydrogenase n=1 Tax=Phycisphaeraceae bacterium TaxID=2026777 RepID=A0A2E2B1D9_9BACT  ali  13  18.................................................................................DTIVIVGPGLLGGSVA-LGLKAAGHTGKVIGVARSQSTLDIAIQVGDQGTTDLVEAAKQADLILLATPLKTF-RDVMGQIADHLKPGCIITDVGSTKSSVLIDAHEQLKPEQLK-----YLVPSHPMAGSETQGCIVTPLDQSDPKTVAEIKDMWDRIGMQVIEMTPQQHDEHSAVISHLPHLLNVMLVQTAMEMGG-----MEMASTGFKG----ATRLASSNPIRSDILTCNRTAILRVIEKMKNKIDKDDRQGLLDDLNQA.. 288
417 3.000e-49UniRef50_A0A286R9Z6 Prephenate dehydrogenase n=1 Tax=Thermogutta terrifontis TaxID=1331910 RepID=A0A286R9Z6_9PLAN  ali  14  25......................................................................................................RRRLADDVIGIARRQTTLRAARRVNAHTTIDLARGVAEADLVVVCTPVATI-PELVRRAAEHCPEGTLITDAGSTKAAIVAALDNNL-------PRGCRFLGSHPLAGSEKTGPIITPTRNTRAEDFDALEEFWTGLGSVVVRMSPEEHDEAIGMTSHFPHLVASLLAGML------PEQWFRFTGT----GFLDTTRIAAGDELWKQILMQNRQALAQELLRAAQALRDGNEKVVEEILTRGKK 274
418 4.000e-49UniRef50_A0A075WG77 3-hydroxyacyl-CoA dehydrogenase n=11 Tax=Euryarchaeota TaxID=28890 RepID=A0A075WG77_ARCFL  ali  18  13.......................................................GAGVMGHGIAQVAARTGYDVVMVDVSEEVLKKAMELIESGLRRLVEK-----------GKMSEDEAKAVMARIRTSTSL-EALKDADFIIEAVTEADLKKKIFAELDRICKPETIIASNTS------AIMISDLATAVERKDKFIGMHWFNPA--PVMRLIEVIRGALTSDETFNITVELSKKMGKIPIEAG-DGPGFFTTRVEAVRLFEIAGIKEIDEMCKLAFGFPMGPFELMDLIGLDTALHIAEYLYNETKEPHYAAPNTLKKLVLSGYVGRK............... 280
419 4.000e-49UniRef50_A0A251VYS7 Uncharacterized protein n=2 Tax=Chloroflexi TaxID=200795 RepID=A0A251VYS7_9CHLR  ali  12  14.......................................................................................GLGLMGASL-CLDLSQHTLCREVRGVARRTDTVLDAFFAGAVATNDLYTGILGADIVILATPVRTI-VHMLEELGPRLWPGTLVMDLGSTKQTICAAMDRLPPGLQP--------IGGHPMTGKETAGFILTPLPRTSPEALDLARELVEAVGARPMVLEAERHDRLVASISHLPFLLASALVHAVADTGAQDPAVWELA----AGGFRDTSRVAASDRMFLDILMTNREAVLDQLERFG-----QHVAELRTLLANGDE 270
420 4.000e-49UniRef50_A0A1Q1FNA6 3-hydroxybutyryl-CoA dehydrogenase n=3 Tax=Halorientalis TaxID=1073987 RepID=A0A1Q1FNA6_9EURY  ali  15  14.......................................................GAGTMGHGIAQAAATSGYDVVMRDVEEELVEEGLQGIESSLSRFEEKDKFSSEE-----------ATAARERVTGTTDLAD-LADCDFVVEAIVEMDVKRDVFADLDETVPEDVVLTNTSTLSITSIASATERADRI-------VGLHFMNP--VPLMEGVEVVVGERTAEETVQLAHDLAEDVGKTTWESD-DKPGFVTNRVLMPWIAEGIRAFDEGVASKADMDRPMGPLELADHIGLDICLDAMETLHEELGDRYQPPYLLKRKVEAGDLGKKSG--KGFYEYGE.... 287
421 4.000e-49UniRef50_A0A1F5C0J6 Uncharacterized protein n=3 Tax=Bacteria TaxID=2 RepID=A0A1F5C0J6_9BACT  ali  13  11.......................................................................................GLGLIGGSLSLALKNINKFIVYGYDIKDESMNIAKYRNIIDVIAGSYKEAVSDADLIIIATPISKIVK-VVSDIKNYLKKGSIITDVGSAKEKIVRRVSEIL-------PGDVFFIGGHPMAGSENEGIILTPTDTTITEPLVTLHSLLTKIGAKVITINPEEHDENVALISHLPHILSTNLVDMIDDRKNNMKNLFKLC----AGGFRDMTRIAAANTMWLDISLENKDKIIKSIDDFKTNLQKDDSESIKKHYVKAQE 280
422 4.000e-49UniRef50_A0A2D4CIR4 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial n=2 Tax=Pythium insidiosum TaxID=114742 RepID=A0A2D4CIR4_PYTIN  ali  13  207...........................AAATRRPASSLLVARSFASSASDIEFKKVGGLMGHGIAQTAAQAGFQVVALDMNQKGLDAGMKRIESSLSKLQARH---------VKKGAITEEQAQQLGRITPTTKTEDLADCDLVIEAIIENDIKKDFYAKLGAIVKPSAVFANTSSL-------AISDFAGSSGRPEKMVGLHFFNPVQI--MKLVEVVRTDDTDAAVFEACKNWVHAIGKHPVSC-KDTPGFIVNRLLVPYLAQAIAMFERGDATKEDIDHPMGPITLADYVGLDTCLFILEGWVRDHPNEFFVPDVLRQKVKEGKLGRKTG--EGFFKW...... 520
423 4.000e-49UniRef50_A0A2D6ZUK6 Cyclohexadienyl dehydrogenase n=8 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A2D6ZUK6_9RICK  ali  13  12..................................................................................EVSIIGPGLIGSSLA-LALKKKKIVKKIIGFDSNKKNLKDAIDAIDEGFSSINKNISNSEIIFLCTPVGTFKK-IINKTLPYLKKKSIITDVGSVKNI-------FSDDINDKIKEKSDLVPAHPIAGTEFSGALCILTPQKSNKSVNKIRKIWEILGMKTTIMSPEDHDKIMSITSHLPHLIAFTIVSTAFNSSKEKKKLLNFS----AGGFRDFTRIASSDPMWKDIFLSNRNNVLETIEEFI-----DDLNKFKNLIKNKNE 274
424 4.000e-49UniRef50_A0A1G0ZEG8 Uncharacterized protein n=1 Tax=Lentisphaerae bacterium GWF2_52_8 TaxID=1798575 RepID=A0A1G0ZEG8_9BACT  ali  13  38..............................................................................................................IGWTRKEEALDKALADGVRGGCDLAKLLPEADITVLCLPVSQIV-SYCREFARHWRPGSIVTDIASVKECIVEAAAPVLAAH------NVHFIGSHPMAGSEKSGVFITPQPASVSDALLSVKKLWELAGAQTMTISAAEHDTLVAHTSHLPHFLAAVLARTVLSGEQ---TPMR--QLGCAGGFRDTTRIASSNPMWREIIAANRAAVLQALKEFRQYLENGDYDKLQNNFEQAKE 285
425 4.000e-49UniRef50_D7DIV6 Prephenate dehydrogenase n=7 Tax=Proteobacteria TaxID=1224 RepID=D7DIV6_METV0  ali  13  3..................................................................................KIVIFGVGLIGGSFALALKKAS--ATHITGIGRSQESLQEALKLGIDAFSDTQEALQDTDLIMIAAPVAQ-TASILQSIKPHLSSNTVITDAGSTKSDVLACAKEVLG------EQFNQFVGGHPIAGAEKSGVNIVLTPTTNKDGVAVVAELWRTCGANVSEMSAETHDGIFAAVSHLPHLLAFALVD-DIASRPNAAQLFSFA----ASGFRDFTRIAGSPEMWRDISLAN................................ 241
426 4.000e-49UniRef50_A0A024G323 Uncharacterized protein n=1 Tax=Albugo candida TaxID=65357 RepID=A0A024G323_9STRA  ali  11  43.........................................................GLMGHGIAQTAASAGFNVVAFDMSSQSLDTGMIRIRDSLDKISAR---------GVKKGTMTEEEAKKRRINPTTDMNQ-LSDCDLIIEAIVEDNVKRSFYEKLDQITKPDAIFANTSSLPISAFADSSKRPS-------QVVGLHFFNPVQ--MMKLVEVIRTEKTDSNVFEKCKSWVHQIGKHPVSC-KDTPGFIVNRLLIPYLSQALLLYERGDATKEDIDHPMGPITLADYVGLDTMLYILDDDPNETA--FTVPDILRQKVSEGKLGRKTG--EGFYKWEERMD. 327
427 4.000e-49UniRef50_A0A1V4XHZ6 T-protein n=3 Tax=Syntrophobacterales TaxID=213462 RepID=A0A1V4XHZ6_9DELT  ali  10  30..........................................................................................................................VRTAGRASAPDLPAMARESDILIVSVPIDA-TPDMIRRVGPHVRGDGLLMDLTSLKTEPVRAMLDATEA---------EVVGCHPLFGPDVPGQNIVLCPGRGRKWLDWLAGLFRENSARVLETTPEHHDRMMAVVQGLTHLDTVVMGLTLREAGMDPEELERFSTPAFRARLKTIEKVFDSPGLYAGIIMGNPAIFEKNLRDLKELVTRGDVEALR........ 246
428 4.000e-49UniRef50_A0A2E6PDH0 3-hydroxybutyryl-CoA dehydrogenase n=145 Tax=cellular organisms TaxID=131567 RepID=A0A2E6PDH0_9PROT  ali  12  12.......................................................GAGQMGIGISQVCATSGFDVNLVDINDEIVDHAKNKIEESLQKLTKRG-KITEDEKTFALGK----------IKFGTDL-SVFKSCQLVIEAVTENDVKNNIYEKICPFLNDSAILTNSSSISITRLAAQTDRPE-------RFIGVHFMNPA--PLMELIELINGIATDEEVYKTIFDFVTSLGKTPV-SSEDYPAFIVNRILLPMINEAVSVAAIDISMKLGAHHPMGPLELADFIGLDTCLSIMQVLHDGLADTKYRPCPLLVKYVEAGWLGKK............... 276
429 4.000e-49UniRef50_X5M7T8 Cyclohexadienyl dehydrogenase n=4 Tax=Rhizobiales TaxID=356 RepID=X5M7T8_9RHIZ  ali  14  26.....................................................................................................RRGGLATHIAGFARSPKTRARARELGDEVCEIAEDAARGADLIVLAAPVGAFA-ALAETIAPVLSQGAIVTDVGSVKSAVVRDVSPHI-------PDGVHFVPGHPIAGTEQSGPDCILTPVADRAEVEKLAQFWRGCGSDVDFMDPHHHDLVLAITSHLPHLIAYNIVGTAADLEVTQSDVIKYS----AGGFRDFTRIAASDPMWRDIFLNNREAVLEML-----GRFAEDLSALQRAIR.... 275
430 5.000e-49UniRef50_A0A1F2P498 Prephenate dehydrogenase n=1 Tax=Candidatus Syntrophoarchaeum butanivorans TaxID=1839936 RepID=A0A1F2P498_9EURY  ali  15  5...................................................................................IVGGAGAMGQWFARFFVERGEAVYILDPRPDSRSI----AEELGAAVV--DRQKLSDADVVLISVPI-DVAPSVIKDTAPVLKDGALLMDITSIKRSPVDAMRSAIKG------RNLEGLSVHPLFGPMMKKQTVIFVPVRSGRLSYWIEQTFREAGAHIEYMEADEHDRLMAVVQGLTHFVYITFGQTLRALGFDIEGSRRYMSPIYEIMTDFVGRVLHQDPLYGLIQMNLDETFINEACRLSEIVKEGDIERFVEEI..... 259
431 5.000e-49UniRef50_D7CP63 Prephenate dehydrogenase n=7 Tax=root TaxID=1 RepID=D7CP63_SYNLT  ali  15  22.....................................................................................................KDSPLVEELIGVDPQDHVGKEAVALGVRRTEKLEAGIENADVVFLCCPLERL-EEVIKQAAPVLKPGAVVTDVGSVKQVVMEW-------FRRWLPGGVYGIGGHPMAGSERTGLVLVLPPGTPSGPFETLSQLISCTGAKIITMDAAQHDRLVATASHLPHLAAVALVNQAGKAPEALG--------LAGGGFRDTTRVASSNPMWEEIFMFNREAVLDQLD-----GFIGELNRLRGYIAAADR 261
432 5.000e-49UniRef50_S5ZMN0 3-hydroxybutyryl-CoA dehydrogenase n=12 Tax=Bacteria TaxID=2 RepID=S5ZMN0_BACPJ  ali  15  9.......................................................GAGVMGSGIAQTAAMAEKTVYLYDVSETALQNGLASAEKSLRRFVKA-------------GELSEPEAASARIRPTIDLAEAVRGADVVIEAVPENALKKDVFQRLDELAGPNAILTNTSELSVTALAAATRRPE-------RVIGMHWFNPA--PVMKLIEIVKGETTSDETVDAIRRLSAELGKETVVV-KDRQGFVTTRAIAAHMIECIRMYEEGVASAEDIDKPMGPLELADMVGLDTLLFVSENMEAYGGRFRA-PQLLRKLVEAGHLGRKTG.............. 275
433 5.000e-49UniRef50_D6TG92 Prephenate dehydrogenase n=3 Tax=Ktedonobacterales TaxID=388448 RepID=D6TG92_9CHLR  ali  15  22.....................................................................................................RRSKAAQEVAGYDLGKGVCQQARRVGAIDAASLEDTVRGADLVILATPVGAI-RALLQTLGPVLTPGTVITDVASTKAQVISWAEEFL-------PETVAFVGGHPMAGKEVTGVELTPTVRTRSGAINKVVALAEVLGARIRFLEPAEHDGQVATVSHLPFLASVALMETAGES-----ASWRDASLLAASGFRDATRLAASPEMYRDICLTNRDAVSRGLDEYIAT-----LQELRRLI..... 260
434 6.000e-49UniRef50_D5MET6 Protein tyrC: Cyclohexadienyl dehydrogenase (Arogenate dehydrogenase) (ADH) Prephenate dehydrogenase (PDH) n=2 Tax=candidate division  ali  13  23.................................................................................QRLAIIGLGLIGSSVG-LACRAHGLAKEIRGADIEPDHRAHAVALGIVAFADIAAAIEGADMVVLAVPVGAIAP-TLEQIVPHLAPGAVVTDVGSVKGVVATTMDRLLPAGNG--------VPGHPIAGRETSGPKCILTPGTDPAAVARVRALWRAVGSEVLQMRPECHDEIFAAISHLPHIVAYALMGAILDL-EGGEHLQALAG----GGLRDFSRVAMSHPMWRDICLANREPILKMIARFAAMISAEDGDGLHQRFARAR. 295
435 6.000e-49UniRef50_A0A0P4WUM3 Uncharacterized protein n=4 Tax=cellular organisms TaxID=131567 RepID=A0A0P4WUM3_9EUCA  ali  12  13...........................................AQSAAMANAIKNVSGLMGAGIAQVAAQTGHSVTMVDIDPVAVGKAEKRIADSISRVAKKKFGEGDEATKFVSESLS-------RLRTSTDAVASVESADLVVEAIVENKTKKELFSKLDNAAPAHTIFANTSSIPIVKIAEATNRLD-------RFGGLHFFNP--VPVMKLLEVIKTSETSPATADAITAWGKAMGKAIVHC-KDTPGFIVNRVFVPYLLSCIRLMDEEVATREDIDYPMGPLELLDYLGIDTIYNICKEWEAYPDMPEFQPPLLERMISEGRFGQKAG.............. 301
436 6.000e-49UniRef50_A0A1J4Z2N1 Uncharacterized protein n=3 Tax=unclassified Candidatus Omnitrophica TaxID=1047005 RepID=A0A1J4Z2N1_9BACT  ali  13  11.......................................................................................GVGLIGGSIGLAVKK-RRLAKVVCGVGRRMSSLKKALKKGAIATLDLESGIKGADLIIIATPISALKIAV---LSDWAKTETIITDAGSTKEFVVKKLEGIL-------PKTTHFVGAHPFAGSEKSKVFVTPTKNTHKKSLSKVKAFWKAIGAEVVQMPPKKHDELVAAISHMPHMIAAALVNAVSR------DMIKFVST----GFRDTTRIAAGDAMWRDIFLSNPKNALKSLDALERAIKKEDVGFLMRQLEAAKK 277
437 6.000e-49UniRef50_A0A182KT95 Uncharacterized protein n=8 Tax=Cellia TaxID=44534 RepID=A0A182KT95_9DIPT  ali  14  337.......LVSEGKLGVKSGEGFYSYKKSAKFLCAMAAAAVNIKHVTVIGG-------GVMGSGIAMITAANGYRVTVVEVSEDAAGRARRQVEKDLRRMAQHVSK----GNEQAEGKFFTDTA--ARLAYSVQLEEVVAGTDLVIEAIVENEQKQTLFKLLDQKAPPHTILTNTSSLSIGEIGSTAARKDRIG-------GLHFFNP--VPMMRLIEVVRTKDTSDGTHEALLAFGKSLRKTCITCR-DVPGFVVNRLLFPVIHEALGMVEVDVAMKLGLGHPMGPFELMDIVGLDTVRSILARNP---ADEGTRPSELLERMVVREKKLGVKSGEGFYSY...... 658
438 7.000e-49UniRef50_A0A1X9M606 Putative 3-hydroxybutyryl-CoA dehydrogenase n=85 Tax=Bacteria TaxID=2 RepID=A0A1X9M606_9BACI  ali  11  9.......................................................GSGTMGGAIAHQAAICGFTVMLRDVEQRFLDNALARMTKLMDRQIEK-----------GKLTEEQKQAITNRITFTTNLEDM-NDCEVVIEAIIEDEAKKAVFNQLDEILRPGAIIANTSSMSITEIASATNRPE-------RVAGMHFFNPPQV--MKLVEVVRGYETSDDTVKELKKLSIDFNKEPIEVKKDTPGFIVNRIMIPQFIEAIRLVEEGVASPEDIDKPMGPFTLQDYAGVDIGLHVMDYFYDEFKDARFAAPLTLRNLVRAGRVGKK............... 274
439 7.000e-49UniRef50_A9V9Q9 Predicted protein n=1 Tax=Monosiga brevicollis TaxID=81824 RepID=A9V9Q9_MONBE  ali  15  568..................................TATARHNISHVTVIGG-------GLMGSGIAQVAAGSQHKVVLCDVSQDVLDKTINRIETSLGRVAKK------KFADDANGAKDFIAATMDNLSTSTDAVKTIGDTDLVVEAIKEDDLKKKVFAEYDAVAKDHTIFANTSSLSIGKIAEATQRKD-------RFGGLHFFNP--VPVMKLVEVIRISETSDETFQALKSFGEAVGKHVVVC-KDTPGFIVNRLLVPYLLEAARMVERGDATIEDVDAPMGPFQLLDYVGLDTTAFIAQGWEDYPEEPLFKPNVIAEKVKEGKLGNKSGQ............. 857
440 7.000e-49UniRef50_A0A1G0ZKD0 Uncharacterized protein n=1 Tax=Lentisphaerae bacterium RIFOXYA12_FULL_48_11 TaxID=1798578 RepID=A0A1G0ZKD0_9BACT  ali  10  2.................................................................................QKLAIIGLGLMGASLG-LAAKKKKIARVVSGYARRDETRSEALKRGIVVYDNPGDAVKGADMVVFCLPVLTI-PEVAAQCIPLLEENCVLTDVGSTKAELVSQMDKLLGKSNAV------FVGSHPIAGSEETGLAVVVTPAGREKHLTAVRRMWEGLGGRVFIMDPKEHDKTIARTSHLPHLVAAMLVNAV---GRDGGKSWRFCGT----GFKDSTRIAAGSEVWHDILKSNHLVVLRELKEFSAMISKKDFPGLKSFLAANRE 275
441 7.000e-49UniRef50_A0A0P9FWA5 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Candidatus Bathyarchaeota TaxID=928852 RepID=A0A0P9FWA5_9ARCH  ali  15  1..............................................MAIKKIAVLGAGLMGHGITQVAATVGFEVNMRDIEESFLSSGMEKIKWSIGKFVEK-------------GRISEEDSKKARIKTTTSLKEATKDVDFVIEAIPENKLKQQVFKEIDGYAPSHAILTNTSALPITEIAAATNRPE-------KVVGMHFFSPPQ--MMRLCEVTRGNKTSDETLNTTVELGKKFGKETIVCNKDIVGFVANRIMVPAGNIICWMVEVDAASIHKAAMPMGTFGLMDFVGIDV.................................................. 241
442 7.000e-49UniRef50_G5F138 Uncharacterized protein n=4 Tax=Terrabacteria group TaxID=1783272 RepID=G5F138_9ACTN  ali  15  1..............................................MTAKKVAVIGSGLMGGGIAQLCAQSGFETINIDIAEAPLAKAQALVGKLLSKKVAKGR-MTEDEKSIVMGRLT----------YTTDYGS-LADADVVIEAVPERDFKQSTFKNIDAHAKDEALLTNTSGININDIASATKRPESVL-------GMHFFYPA--PVMKLAELIRGEKTSDEAYVVAKEFATAIGKTTVDA-PNQPGFIVNRIIVPYQNEGAFLVDVDTAMKLGCNHPMGPCELMDFTGIDVVYATMKGLYDNFHDEKYRPCPLLKEMIDAGTLGRK............... 273
443 7.000e-49UniRef50_A0A2H1WMB9 SFRICE_009004 n=1 Tax=Spodoptera frugiperda TaxID=7108 RepID=A0A2H1WMB9_SPOFR  ali  13  14..........................................SASLNAVKTVTVVGGGLMGSGIAQVAAQAGQNVTIIDVNSELLEKAQKSIQTNLTRVGKKLYK------GDEAKIANFVKESAERIRVSTKLEDG-ADVDLIVEAIVEKDAKQELFNKLDVLSPPRTIFTNTSCISVNAIGAGIQRKDRYG-------GLHFFNP--VPVMRLLEVIKCDNTSEETYQTMMEWGKSVGKTCITC-KDTPGFVVNRLLGPYSAEAIRMLERGDATKEDIDLPMGPFELADYTGLDT-NRLAQQNEVFAPIEL-----LEKMVAEGKYGIKSG--EGFYKYNKN... 307
444 7.000e-49UniRef50_A0A1Q9PAA9 Putative 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Candidatus Thorarchaeota archaeon AB_25 TaxID=1837170 RepID=A0A1Q9PAA9_9ARCH  ali  16  11.......................................................GAGLMGAGIAYVSAWNGFNVTVVDIKQEFIDAGMERIR-------------TDVMTGIDKGKISMTDAEGLRLNATVNVEEAVKDADLVIEAIFEMDVKKEVFAKVDAAAPAHCILTNTSSLSIDELAGSTKRPD-------KFIGMHYFSP--VPAMKLLELVIGDKTSEETIAAAESVGKTQNKKTVIA-KNSPGFIVNRLLMPVMREALLMLERGEATKEEIDLAMGPFTLGDFVGLDITFNAMSTLYREIGDCFKPPETLKNLVDAGNIGMKSK--KGFYSYGAEEDE 289
445 7.000e-49UniRef50_A0A1Y3GDE5 Prephenate dehydrogenase TyrA n=1 Tax=Methanonatronarchaeum thermophilum TaxID=1927129 RepID=A0A1Y3GDE5_9EURY  ali  8  59.........................................................................................................................................IKNSDIVIISVPIKATTK-VIKEVGPKMKKNSLLMDVTSIKEQPVNAMKKH-------VPKHVEKIGTHPLFGPEFKDKNIVLVPINADKWLDKVKKYITNQGGNIRTMTASEHDKAMAVVQGASHLLLILFGSILKNQKFNINQNNDLTTPTFRLLHKDLDRILVQNPLYASIQTHNRYITIKDYQKMLETIETQDTEKLSQIIENID. 269
446 8.000e-49UniRef50_A0A169P1E6 3-hydroxybutyryl-CoA dehydrogenase n=5 Tax=Actinobacteria TaxID=201174 RepID=A0A169P1E6_STRLU  ali  15  9.......................................................GAGLMGSGIAQVSAQAGWDVVLRDVTDAALTRGTDAIRTSYERF-------------VAKDRMTAADAEALGRITATTDLEAVADADIVVEAVFEKEVKHEIFRSLDKVAKDGAVLANTSAIPITKIAAVTERPEAV-------VGTHFFSP--VPMMRLCELVRGYKTSDETLAFAREFAESVGKTCIVVNRDVAGFVTTRISALV-VEAAKLYESGVATAEDIDHAMGPLTTTDLTGVDILVNATNNIYTETQDEKFAPPELMRRMVDAGDIGRK............... 274
447 8.000e-49UniRef50_A0A098B2J7 3-hydroxybutyryl-CoA dehydrogenase n=50 Tax=Bacteria TaxID=2 RepID=A0A098B2J7_DESHA  ali  11  1..............................................MTMTKIGVLGAGSMGGGIAHLAAVKGLDVILCDVEQRFVDGAVQRIAGFLDKNVAKQKMTVEE-----------KDAALQRITTTTNMED-LASVPLVIEAIFEMDIKKTAFQKLDQICGPETIIANTSSMSITTLAAATSRPD-------RVVGMHFFNPPLV--MRLVEVIRGYYTSDETVAKVSDVSRAMGKTPVEVKKDTPGFIVNRIMMPQFLEAVRIAEEGIASIEDIDTPMGPFELMDFTGVEISVHVSDYFVEEYKDMKWNAPQLLKNIVRAGRLGKK............... 275
448 8.000e-49UniRef50_A0A2S8F5R2 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=3 Tax=Blastopirellula marina TaxID=124 RepID=A0A2S8F5R2_9PLAN :  ali  12  2........................................................................YQANTVADFKQIAILGVGLIGGSIGRAALA-RKIADKVVGIGRSEEKLARAQRQGCEATTQWQAGIRGADLIVVCSPVESIVP-LVEQLVPFCQPGTIITDAGSTKQKIVDTL---HSSESIRGRKDVYFVGSHPMAGSDKSGRVTIVTPVAETERTAKVRKFWESLGSEVHEMSPSEHDAIVAATSHMPHVIAALVAAS------TPEAMLKFTST----GWADTTRIAAGDDLWRQILSTNRGHVLQTLANFEKLLEAGQEEHWIKLLKQGK. 283
449 8.000e-49UniRef50_A0A1F5UPQ9 Uncharacterized protein n=1 Tax=Fraserbacteria sp. (strain RBG_16_55_9) TaxID=1817864 RepID=A0A1F5UPQ9_FRAXR  ali  15  13.......................................................GAGTMGHGIAELAALAGYEVKMRDINEEFVQKGYKQIEWSLNKFVEKGALTAEIAQQTLKRIIPL-----------VDIKRTVEMADVVIEAAPIMKLKKELFTDLDKYATKHAILTNTSSLSITEIAKTTKRPA-------QVVGMHFFNPPV--RMALVEVIKGEKTSEEVMQLTVDLAKKMGKTPIRVEKDVFGFIVNRVLGPFMFESAWMVSRDEATIQQIDSPMGPFELQDLTGIDI.................................................. 245
450 9.000e-49UniRef50_A0A2S6SY49 Uncharacterized protein n=2 Tax=Alphaproteobacteria bacterium MarineAlpha5_Bin2 TaxID=2013077 RepID=A0A2S6SY49_9PROT  ali  12  6................................................................................FDSVLIIGVGLIGSSLARAIREYD-LAKKIYGLDTSRTNLAKCNELEIKGADSLDSFSEQFDLVIICSPLSTYK-SIFASLNSYITQDTLVTDVGSTKMSVIRDFKE------TVKNSFIQFLPSHPIAGLEKSGAEFIITPNTNNDTINVIKRFWTAIGMQIETMDAEHHDRVLAMTSHIPQLIAYSMVSTAIELETHLDEVIKYS----AAGFRDFTRLAGSDPMWRDVYSLNKDAVLEMLNKF-----TKDLSTLQKAIRNND. 270
451 9.000e-49UniRef50_A0A142LK81 Prephenate dehydrogenase n=2 Tax=unclassified Betaproteobacteria (miscellaneous) TaxID=33809 RepID=A0A142LK81_9PROT  ali  12  6..................................................................................AIVGVGLIGTSFALAAKRDLTPESAPRIIGVDLDVQYVEQARQRGAIDAAGTFEQAASADLVLLAVPVRQM-PQVLAALKPHLAEHTVIIDAGSTKQDVIAAARLRLGD------RFRQFVACHPIAGRERHGPNVVLCPENSDTTVETARLAWQAVGAKVIEMTAVTHDAVFAAVSHLPHILAFALVEALAARPNA-----KLLFEHAASGFRDFTRIASSPEMWRDVALNNREALLRRVAAVRDMLQASDGDAIYEIMQRAQR 279
452 1.000e-48UniRef50_B2IXG8 Prephenate dehydrogenase n=14 Tax=Cyanobacteria TaxID=1117 RepID=B2IXG8_NOSP7  ali  10  76...................................................................................................HASPRQVTIIGGRGRMGRLFQEQLSLVGHNVSILAEQLLSQAELVLVSVPIEH-TVDVIKRAAKYLASNTALCDITSIKTQPTQAMLEHHCGP---------VMGLHPMFGPNIKGQKVVVCPGRNDDSFQWLLDFLKSKGGELIVCTPEEHDRMMVIIQATQHFCRFSLGVFLAQARVEIEQSLTMSTPNYRQEIDIVKRLFAQNPLCVDIMLANAISFLATYSRLARLVARKDREALIKEFENTQ. 329
453 1.000e-48UniRef50_A0A1Z9ICH8 Uncharacterized protein n=4 Tax=Verrucomicrobia TaxID=74201 RepID=A0A1Z9ICH8_9BACT  ali  10  25.............................................................................HSVFDKITVIAPGLLGASICKAARK-RSLARQIAVWARRTEAREALLQQDDSAPTEIEESCSGSDLVILCAPVKRII-EIAERIAPHLDSNPIVTDVGSVKSALSRACAAALEGKAR-------FVGSHPMAGSEKTGMEVTPFPNADADALKSVSDFWGALGSSVIEKSPEEHDAIVANVSHLPHLIASAIATHLAHSYPDSN-------RYCGNGLRDTTRIAAGDPLWREIISQNRDEILRALASF-----EDELHALRSSIANEDE 289
454 1.000e-48UniRef50_A0A2K1NPI2 Prephenate dehydrogenase n=14 Tax=Petrotogaceae TaxID=1643949 RepID=A0A2K1NPI2_9BACT  ali  14  3.......................................................................................GTGLIGTSLALAFKETNSI-RKISGYDVNKTNSQDALKLGIDEIENLQDGIPTADIIIFATPVESIK-DILTNTIELIKPGTIVSDVGSTKYQIVKI-------FDSFVDKNINFIGGHPMAGTENSGPVLVKTKKCSNEAFEKFRCLINKIEANPVIMEAQKHDKIVAVTSHLPQIVSFYLAKTLLKEKD------EDFLKLVGSGFKDTTRLAKSDPIWIDIFKQNKENILNSVENFKNNLNENKYKEIVEELKQVRE 269
455 1.000e-48UniRef50_A0A0W8FT57 Uncharacterized protein n=13 Tax=root TaxID=1 RepID=A0A0W8FT57_9ZZZZ  ali  12  2.....................................................................................................KRIKAGIIGGTNGMGKWFAGLLRKCGRKTRLQINDLVRLCDVIVVAVPISA-TVDIIKQVGPLLSEDKLLMDLTSLKKEPVKLMLDSSAA---------EVIGCHPLFGPDVTGQNVIVCPARSKKWLIWLKSVFKKNKMAVWEATPEKHDKMMAVIQALNHFNTITLGMALAQTNITPAEINKFSTPIFRTKLDIIRKVFESPELYLDIITKNPQT------GKMLDIYEKSLKEIREKIKSSR. 241
456 1.000e-48UniRef50_UPI0002EDFC55 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Zavarzinella formosa TaxID=360055 RepID=UPI0002EDFC55  ali  15  21...................................................................................................AAKARGLSRHVVGIGRTPANLNRAKELGISFTTNLAEGVSSADIIVVCSPVDLIAAHVL-EAAKAAKPGALLTDVGSTKGNIVRDVEAKL-------PPGVDFVGAHPLAGSEKQGAEFARVDLTKPAAKERATLFWQTIGSQVRTLSPEEHDLALATTSHLPHYIAALLARQLPEA----------WRPFAATGFRDTTRIAAGDPLWTAIASENTLAISHALD-----VFAGQLETLREA...... 255
457 1.000e-48UniRef50_A0A2A5V8D3 Cyclohexadienyl dehydrogenase n=1 Tax=Pelagibacterales bacterium MED-G40 TaxID=1986248 RepID=A0A2A5V8D3_9PROT  ali  15  16.............................................................................................SILRAINEKKIANEVNVFDKSKEVLSFIKQENLCKNIFNDITKCIQDSDLIIISAPLSSYK-EIILSMKSNLKKNAILTDTGSVKKEVNKIIKN-------LNLKDIVWVSSHPIAGTEESGPKIISTEEESEDEIKKLKKFWESLGSKVKIMSMEEHDYILSLTSHLPHAIAYNLVRTAIGNDSKFNDIIQYS----AGGLRDFTRIASSNPMWRDIFIDNSENILKSLEELKKAISSKNPEGLNKIFSSTKE 279
458 1.000e-48UniRef50_A0A0S8FQ39 Uncharacterized protein n=1 Tax=Planctomycetes bacterium SM23_32 TaxID=1704029 RepID=A0A0S8FQ39_9BACT  ali  11  1...............................................................................MFKKVAIIGPGLIGGSMG-LAMRRRGLAETVVGIGRRRESLDKALEVGARATLKPRQGVDGADLVVLATPISAFA-QLAAEVAEALEPQAVLTDVASTKVKVIETVSSAL-----HTRPDVAYVPSHPMAGSERRGPVCILTPLTQPDTKSRIARMWEQMGARVVSMSPQAHDRAVARISHMPHLMAAAVVQMLDE---------GDMALCGRGLLDTTRIASGSPDIWLDICKTNREEIRGAVADLVAL-----LAQTVEALDEGD. 261
459 1.000e-48UniRef50_A0A0E4GCW6 Prephenate dehydrogenase n=3 Tax=Firmicutes TaxID=1239 RepID=A0A0E4GCW6_9FIRM  ali  14  10.......................................................................................GLGVIGASLG-MALRNSSSVIQVAGRDLTEKTALQALEVGAIDEHLDARLLGECDLVVIATPLNTI-PQVAAEIKDSLKPGALVSDVGSVKGWVMQVLQQEL-------PAEVHIVGGHPMAGSEKSGLVLTPQPDTPQDILAGLIELLKTIGARIAIMDAQEHDQAVAQVSHLPHLISAALVNNLQNNPEALA--------LAGGGLRDTTRIAASDPLWENILMLNSNAVTQEIKNMQEL-----LQNYLKALEAGDK 261
460 1.000e-48UniRef50_A0A2M8F788 Uncharacterized protein n=1 Tax=Candidatus Peregrinibacteria bacterium CG_4_9_14_0_2_um_filter_53_11 TaxID=1974780 RepID=A0A2M8F7  ali  14  2.....................................................................................................SLPRTAIIGGRGKLGAAFAGLFEKAGCEVELTPRQACAQADITIFSVPIS-VTPAVINEVAPAARPGSLLADLTSIKLPAMEAL-------ARSAPDGVEILGLHPLFGPHMAEQVIAVCPLKTGPRAEWLSNFLVQNGAHLKKTTPQEHDEMMAVIQGITHFSAIASGLALKKLGVDLEKTLAFASPIYELRLAMIGRILGQSPLYAEIQIENPKAYKQAIDELSQTVDSSDEQAFQTIFREAAD 257
461 1.000e-48UniRef50_M7NXV2 3-hydroxybutyryl-CoA dehydrogenase n=19 Tax=root TaxID=1 RepID=M7NXV2_9BACL  ali  11  7.......................................................GAGTMGNGIAQVFAQHDHEVVLCDQSGEALERAKQTMENSLKRIYGKQGKTDQDIADT-----------LAKISFTLDI-ETLSDREFVVEAVAEMEVKLEVFRKLDAICPDEALLTNTSGLSVTEIAASTGRPD-------KVVGTHFFNPP--PIMKLVEVVTGEETSEETVKAVREICGSIGKETIQ-TVDSPLFIVNRILVPMVNEAMFVYQEGLASKEDIDKAMGPLALADLIGLDTLLFVCETLLEETGDSKYRPQILRKKVRAGHLGRKTGR............. 274
462 1.000e-48UniRef50_A0A2A6ATW0 T-protein n=7 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A2A6ATW0_9ALTE  ali  12  67................................................................AGVSA----DLTEDLLRRIMRESYHTQNNRY-RCVNPEAGNIVIVGGRGALGRVFVGLFEKSSYNVSVDDWEVLANAKLVVVAVPI-TLTESVIRRL-NNLPRDCILADITSVKAKPLEAMLETHQGP---------VVGLHPMFGPDSPGQVVVVCHGRHEASYEWLLQQMITWGAALHYSSAEEHDQAMAYIQVMRHFNTFVYGAHLKGENPDLRSLTVFSSPIYRLELAMVGRLFAQPELYADIIFHNPKNF------ALLRRFHNRFGDALDVLESGDK 340
463 2.000e-48UniRef50_A0A2D9XUK0 Uncharacterized protein n=1 Tax=Gammaproteobacteria bacterium TaxID=1913989 RepID=A0A2D9XUK0_9GAMM  ali  11  9.......................................................................................GLGMIGGSIA-ISLKKRNISKNIYAYDKNKKSLTFAKKIIDDYDTNSFKLLKQADLIIVCAPINSYKR-IFEIIKIHKKPECIITDVGSTKTSVINCANNIFGKDQKC------FVGSHPLAGKETSGVKNA-CPNTNKASLNKIKSFWKKIGCKIETLTPPMHDIIMSETSHVPHLISYSLVNSIYKSKH-VKNIDKFTG----GGFKDFARIARSNPMWRDICENNRKNILSSLRLFILKINQNNYKELHSFFEKTK. 277
464 2.000e-48UniRef50_A0A0S8EQK5 Uncharacterized protein n=1 Tax=Myxococcales bacterium SG8_38_1 TaxID=1703408 RepID=A0A0S8EQK5_9DELT  ali  11  15.........................................................................................................................EVQSADLDTELRPEDVAATADVVVISVPIRE-TRAVIEKLGPLVRKDALLMDVTSIKTDPMEAMLASSKAS---------VLGTHPMFGPGVQGQRVVICPARGDEWLAWARQMFTARGLVITETTAAEHDSMMAIVQVLHHFKTQALGLALSRTGTSLEDTLRFTSPAYLLETYVTGRHFAQPELYGPIEMLNPDSFRGAAADLAKILANQDQAAFDRVFADVR. 239
465 2.000e-48UniRef50_UPI00055055C3 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Lachnospiraceae bacterium AC3007 TaxID=1408322 RepID=U  ali  12  7.......................................................................................SLGLIGGSIAKAREKYQDARIVAYNRSREPLVAAFRDGVIDAATHDIDDTFKDCDYIFLCAPVQTNM-SFLKKLDPYLKDGTILTDVGSTKLNIHEAVKK--------DAPGAHFIGGHPMAGKEKSLIKLTPSDTVTEKETAAFKEFIASLGCNPITVEPKLHDNIVAAISHVPHMAAYGLVKLVR----DKDTPENYMKETAAGGFKDTTRVASSDPMWEEICLANKENIAGLLDEIRFLISKGDSEALHALFKDIKE 275
466 2.000e-48UniRef50_Q47X59 T-protein n=29 Tax=Gammaproteobacteria TaxID=1236 RepID=Q47X59_COLP3  ali  11  38.........................SKVGQLKSGVGRPIYDAKREASLFAKRR------------QQASEAGLDLIEDVLRRLMRDSYVSQDASGYRCVNPECKKVVVVGGKGQLGSVFVDLFQRSDYQVAPNSEAILADASLVIVAVPI-RLTTMVINHL-NNLPKECILADLTSIKESPLFEMKKVHAGP---------VVGLHPMFGPDVTGQTIISCEGRNPEQYQWLIEQFEVWGAKIYPVQAHEHDQAMSMVQVMRHFSTIAYGYHLMSEGADIENLVAMSSPIYRLELIMVGRLFAQDPLYADIIFANKDNFAYRFLELLEDVSLDDKDAFVDMFNNVS. 354
467 2.000e-48UniRef50_F4A091 Prephenate dehydrogenase n=1 Tax=Mahella australiensis (strain DSM 15567 / CIP 107919 / 50-1 BON) TaxID=697281 RepID=F4A091_MAHA5  ali  13  1............................................................................MDDIAAVAV-VGLGLIGGSIARALRYKADIH-RIIGIDKNADYVHAALEDGIVVDDPNIPGPIDADIVFICTPVSSV-QAMVSAIVPHVKKGCILTDTASVKAPIMYGIETILLGDTI-------FIGGHPMAGTEKSGYHYILTPTCDDEALDKLSHIIRSMGAIPVIMDADTHDEVVAAVSHLPHVLASSLMHFTKDQ-----HNAEYMKLLAAGAFRDMTRIAASNPMWREICLANASAVKRSIDDFIAV-----LSRFANMLDDKD. 269
468 2.000e-48UniRef50_A0A2D7NH87 Bifunctional chorismate mutase/prephenate dehydrogenase n=2 Tax=Planctomycetes TaxID=203682 RepID=A0A2D7NH87_9PLAN  ali  13  84..............................................................GLSDSVVENVYRVLLTASRERQADLGTEVPDNL------SQRTVAVIGGHGGMGKLFANLFESVGQEVTLTPTEAASRADAVLISVP-MRATVEVIRKIGPSCRKDGLLFDVTSTKVEPVEEMIQN---------SCCDVIGTHPMFGPSVTLQEVVLVHGRLREWPNWLSRCLKARGMLILESDAEEHDRSMGIVQVLTHLSTQVLGLAMARLGVPITQTMRFASPVYLMGLIMTARHFQSSELYGAIHMSNPNAFSQSLTDWLESVKNKDQEEFDRLFTEA.. 370
469 2.000e-48UniRef50_A0A2K8SHN3 TyrA, chorismate mutase / prephenate dehydrogenase n=12 Tax=Cyanobacteria TaxID=1117 RepID=A0A2K8SHN3_9NOSO  ali  11  79.....................................................................................................SYREITIIGGHGRMGRLFKEQLSLVGHNVSVDWEQLLNQAELVLVSVPIEH-TVDVIKRAAKYLGPNTALCDITSVKTQPTQAMLEHHSGP---------VMGLHPMFGPNIKGQKVVVCPGRNDDSFQWLLDFMKSKGGELIVCTPEEHDQMMVIIQATQHFCRFSLGVFLAQVKVDIKQSLTMSTPNYRQEIDIVKRLFSQNPLCVDIMLANAISFLKTYSRLARLVARKDRDALIQEFE.... 327
470 2.000e-48UniRef50_Q1K0U0 Prephenate dehydrogenase n=27 Tax=Deltaproteobacteria TaxID=28221 RepID=Q1K0U0_DESA6  ali  11  8..................................................................................KIAIVGVGLIGGSFALALKRAGVVARVGWDADRNNLHLAHELQVIDQLPSTLAQAVDGAELVMLAVPVGAM-ESAAREVIPLMASGAILTDSGSVKQCVVECLE------PLALQHGVRYVAGHPISGTERSGCILTPTAQSDVAALDTVTLAWQAAGSEVVTMDVLKHDRILAAISHLPHMIAYSLVNSVSDYDRYDENILDYS----AGGFRDFTRIASSDPMWRDIALTNKDSLIEMIDQFEEDIQQADGERLYEFFRRSK. 282
471 2.000e-48UniRef50_A0A2E0WWU0 Prephenate dehydrogenase n=2 Tax=Planctomycetia TaxID=203683 RepID=A0A2E0WWU0_9PLAN  ali  14  3...............................................................................LYERVAIVGVGLIGGSIGKAL-RERGLAGEVVGVGRRQTSLDKALEAIHRGTTRFPEGVKDADVVIVATPVAGVVDAV--RSAAFFAPKAVLTDAGSTKAEICRELREVSPDLPQLRPGPNRWIGSHPLAGDHRTGPEVVVTPETAPGLVDRVTEFWEALGAEVVRLSPEEHDWAVAATSHLPHLVASALA---AATPED-------WLRLAATGWGDTTRIAAGDELWTQIFTQNRGAVLDALRRFEAAIENDDRPALAEQLQDAKR 281
472 2.000e-48UniRef50_A0A2U0RXX2 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Candidatus Bathyarchaeota archaeon TaxID=2026714 RepID=A0A2U0RXX2_9ARCH  ali  14  24.........................................................GLMGHGIAQTFAVKGYDVCLLSRNKDSLDKAVEEIKWSLGKFAKKGAISSVEV-----------EAALSRIKTTTSYVEAVGDADLVLESVSENELKRHVFSKIDELAPSHTLITNTSTLSVTEMGKATKRPE-------KTVGMHWFIPPQLT--QLIEVIRGKDTSDQTLNAIMEASKRLGKTPILCKKDVRGFIVSRILVAMFNEAFSMMEIDASVRYVGGFPMGWFELVDFVGVDV.................................................. 253
473 2.000e-48UniRef50_A0A2S8SRP8 Prephenate dehydrogenase n=1 Tax=Abditibacterium utsteinense TaxID=1960156 RepID=A0A2S8SRP8_9BACT  ali  15  1...............................................................................MFQRLVIVGPGLIGASFGLAIKKL-GLAREIIGVARSQETQNGAVQIGAFATSDLIEAATGADFVFLAPPVGQMKL-ICQQIAPVIGRGALITDAGSTKAQVVRDCEAIFG-------QGARFIGGHPMAGSEKVGPTWILTPTSNSAALEQMQKMVTSFGAKPLILDAQTHDELLAITSHLPHLTAAALTQVFGSARAK----NEVASQLVAGGWRDGTRVAASAEMWRDICLANRDAILSALENLSLELNHLRLDSLLDWLQSA.. 276
474 2.000e-48UniRef50_M4BEM4 Uncharacterized protein n=2 Tax=Stramenopiles TaxID=33634 RepID=M4BEM4_HYAAE  ali  12  5.........................................................GLMGHGIAQTAASAGFQVVALDADSKGLDSGMKRIEASLSKLQSRS---VKKGLLTQQEADERVAAVLARVTPTTN-VDALADCDLVIEAILENDVKKEFYATLGHLAKPSAILANTSSL-------AISDFAGSSGRASQVVGLHFFNPVQL--MKLVEVVRTDVTDPKVFDACKQWVLDIGKHPVSC-KDTPGFIVNRLLVPYLAQAIAMYERGDATMEDIDHPMGPITLADYVGLDTTLFILEGWVRDHELAFFVPEILRKMVAEGKLGRKTGE............. 279
475 2.000e-48UniRef50_A0A0Q6XII4 Prephenate dehydrogenase n=3 Tax=Burkholderiales Genera incertae sedis TaxID=224471 RepID=A0A0Q6XII4_9BURK  ali  10  9.......................................................................................GCGLMGGSFA-LALKRAGLVKRVIGYSKSPSTTERAKKLGVDTAESALLAVSGSDIVLMAVPVSA-SEATFRAIRHLVEPGVLFMDVGSTKRDVVDAARRVLKDRLSS------FVPAHPIAGKEVAGVIITPLPQTDPDLVQKATDVWSAIGSQVLRMTPENHDAAFAAVSHLPHMLAFAFFSSVAKQPAGRDF-LSLAGP----GFRDFTRIAASDPVWRDILMSNREEILKQLDAMEHVMKSGNVEALEDLIRNASD 278
476 2.000e-48UniRef50_A0A1I6LD01 3-hydroxyacyl-CoA dehydrogenase n=2 Tax=Halobacteriales TaxID=2235 RepID=A0A1I6LD01_9EURY  ali  14  14.......................................................GAGTMGAGIAQVAATAGYDVTMVDVESDLVDAGFDRIDDSLDRL-------------VGRDDLTREEADAALDRIDGSTETALGDADLAIEAVVEMDVKRKVFADLDDVCGDGAILTNTSTLSITSIAEATDRPA-------QVVGLHFMNP--VPIMPGVEVVDGEKTSAEALRTAHEFAESLDKETWESD-DKPGFVVNRVLMPWINEGIRALDEGVATKDDIDRPMGPLELADHVGLDVCLHASETLHDELGD-RYKPAYLLKRKVEAGDLGKK............... 277
477 2.000e-48UniRef50_A0A291QFE2 3-hydroxybutyryl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase n=542 Tax=Actinobacteria TaxID=201174 RepID=A0A291QFE2_9ACTN  ali  14  9.......................................................GAGLMGSGIAQVSAQAGWDVVLRDVTDEALTRGTDGIKASYDKFVSKGKLAAEDAEAAL------------GRITTTTDLDAVADVDIVVEAVFEKEVKHEIFRTLDKLVRDDAVLANTSAIPITKIAAVTERPE-------RVVGAHFFSP--VPMMQLCELVRGYKTSDETLARTREFAESVGKTCIVVNRDVAGFVTTRISALV-VEAAKLYESGVATAEDIDHAMGPLATADLTGVDILLHATSNIYTESQDEKFAPPELMRRMVDAGDIGRK............... 274
478 2.000e-48UniRef50_A0A0S3PAS6 Chorismate mutase/prephenate dehydrogenase n=11 Tax=Nostocales TaxID=1161 RepID=A0A0S3PAS6_9NOSO  ali  11  18.....................................................................................................KSRQVTIIGGRGRMGQLFAQKLMAIGHKVNVDYADALSQAELVIVSVPIEH-TVAVIERAAKHLSSTTALCDITSIKIQPTQAMLAHHQGP---------VMGLHPMFGPSVSGQKIVVCSGRGDDSFQWLLDFMQNQGGELITCTPEEHDQMMVFVQATQHFYRLSLGVFLAQANIDLQRSLLMSSPSYRQEIEILKRLFKQNPLCVDIILATEEELAETYQRLAKLVEQKDREGLIKEFEDNKD 270
479 2.000e-48UniRef50_A0A2H5ZHV3 Prephenate dehydrogenase n=1 Tax=bacterium HR30 TaxID=2035425 RepID=A0A2H5ZHV3_9BACT  ali  13  5................................................................................FERVAVIGVGLIGGSLA-LAARTAGLFGHVVGVGRSLTNLEEALRRQVSYTLDPQAAVANVDLVVLSVPVRAMAP-VVAQCRNALAPGALVTDVGSVKRYVLDTVEPVL-------PAGVRFVGAHPIAGTETSGVRCVITPGTDTEAVLQVRALWEAVGMEVVEMSPDRHDSALAWVSHLPHVLAFAATRALERH---LPEAAGLAGPSFASLTRVA---ASSAETWVDIFVANRSAILATLEELRHTICQATPEELRAWLEESR. 277
480 3.000e-48UniRef50_A0A1V5DYE5 Putative 3-hydroxybutyryl-CoA dehydrogenase n=9 Tax=Bacteria TaxID=2 RepID=A0A1V5DYE5_9DELT  ali  13  10.......................................................GAGSMGRGIAQVSAQAGYQVALYDMNREALKQAFANIENMLGKAIERKKITEQQKADTLKRILTPA-----------SLKEACEDAQLIVEAVFENEIKKKMFSELDSLASDNAILTNTSSLPITAIAAATKKPS-------RVIGIHFMNP--VPLMKGVEVIPGLATSPDVTNAAMQFVESLGKIPAKA-VDYPGFIASRILDVMLNEAVYAVDVDKAMKVCLNFPMGPLELIDLAGLDILLNVMETMQKELGD-KYKPAPLLTKMVRAGYLGRK............... 273
481 3.000e-48UniRef50_A0A1M6GT38 Prephenate dehydrogenase n=1 Tax=[Clostridium] caenicola TaxID=659425 RepID=A0A1M6GT38_9FIRM  ali  13  24.....................................................................................................RNRSDKYRIIAWDRDSKTLEKARAIDIAVTSELTE-FQACDMVFLCVPVYAMK-TVLEMLMPHLRPDCVITDVGSTKGDVSRIMAEAGVSDK--------YIGGHPLAGSEKSGYVITADESTPEHRKQLLKSVIRDLRAIPLEMTPEEHDRVTAAISHVPHVVASLLVNLVKR----LDGPEEYMKTIAAGGFKDITRIASSPELWTGICLSNREKVLQTL-----AVLEEHLSEFCSMLQQGDK 267
482 3.000e-48UniRef50_R7H9G8 Uncharacterized protein n=2 Tax=environmental samples TaxID=2231195 RepID=R7H9G8_9FIRM  ali  13  17..............................................................................................SIAKALRAYRPQC-HMIATSRSLSPLYQAQKDGVEVTNCVNEQFSGCDIIFICTPVVTITK-YFELLKPLIKSSCILTDVGSVKESIYTAAKNAGLEN--------NFIGGHPMAGSEQSGYKYVITPHTSKEHLDAYVELVKDIKAVPIVMDPATHDYCAAAISHVPHLVSAALAKLVKDA--DTGDYKDYMHLLAAGGFKDTTRIASSPEMWEQICAANPTAI-----SQLLGEYINSLTAVKEHIDSGD. 267
483 3.000e-48UniRef50_A0A1Q7Y2Q1 Uncharacterized protein n=54 Tax=Candidatus Rokubacteria TaxID=1752708 RepID=A0A1Q7Y2Q1_9BACT  ali  13  3.................................................................................QRLAIVGVGLLGGSVAKAA-RSGELVREIVGVGRDEARLGAALSDGDRVTTDLNVGVSDADFVLLAVPVLAI-EALLPRVWRAAADGAVVTDVGSTKAGIARVADRLTAG------RALAFVGSHPMAGSERSGVVVTPTDRTEPHAVKAVAGFWEALGARVSALDPETHDQAVAAISHLPHLVAYALVDGAAR--------FGPTALLAARGFKDTTRIAASDPVWAEIFLANRAALAASLDAFRQALAE............... 254
484 3.000e-48UniRef50_A0A2H5YJI9 Prephenate dehydrogenase n=4 Tax=Bacteria TaxID=2 RepID=A0A2H5YJI9_9BACT  ali  14  25....................................................................................................KAARLRGVELVGYDRDSETRTKARRMGAREARDVGEAVSGASMVIVATPILAI-REVLREAAPHLTEGSVVTDTGSTKAAVLGWARELL-------PSGVHFVGGHPMAGKETQGIDHAPDPDADERAVRAVLGLVHAVGATPLFIDPEEHDQYVAAVSHLPLVLATALFTLVRGS-----TGWQEMAPLAASGFRDTTRLASGDPMSHDICITNREALLHWLDRMI-----GELYRYRRLIAEG.. 267
485 3.000e-48UniRef50_A0A1F2WJR4 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Actinobacteria bacterium RBG_13_55_18 TaxID=1797197 RepID=A0A1F2WJR4_9ACTN  ali  13  1..............................................MEIKNVFVVGSGLMGGGIAQVSAVAGYKVKMHDVDDERTSKGLDAIKKSLEKFVSKEK----------LSKEQYESAV-ANISTTTKLEDA-SDADFVVEAVFESDVKKDVFGRLDEICPPHTILSNTSAIPITAIASVTKRRGQVL-------GTHFFSP--VPLMRLCEIIRGLETSQETMQTAELWAQSLGKETVIIRKDHAGFIANRLYIPMTMEAVRMLEIDKAMRLGYNLPMGPLELADMVGLDVISGAATAIYNDIDDPKYYTPPLLKRMLAAGLLGRK............... 275
486 3.000e-48UniRef50_A0A2H6ADV5 Prephenate dehydrogenase n=1 Tax=bacterium HR36 TaxID=2035431 RepID=A0A2H6ADV5_9BACT  ali  14  4.................................................................................ETLVIIGVGLIGGSIG-LASRRRGLARRVVGVVRRAESVVDLVQRGIEATTNLPEAVQEAQLVVVCTTVDTISRYVL-DAASHAPVEAILTDAGSTKGQIVAEVESGWGRVSRAAREGCRFVGSHPLAGSEKSGVLVTPTGQTCAEATERVAEFWQALGGRVQFMSPEDHDRALALVSHLPHLLASALAGILPGKWADL----------AASGFRDTTRIAASPEIWAPIFLHNRHAVLEA......................... 255
487 3.000e-48UniRef50_A0A0R0LQP7 Ketol-acid reductoisomerase n=2 Tax=Ferrovum TaxID=416212 RepID=A0A0R0LQP7_9PROT  ali  12  10.................................................................................RRIAIIGVGLIGGSFA-LAMREASRDITIVGYDKDEVNLAAAKQLGVSAVHSLAAAVKEADVIQLAVPVGQM-ETVLSEIAKVISATAIITDVGSTKGNVIEVAKKILGAAVNR------FVPVHPIAGAENSGVRAARTDFTDPLPFEIIRRCWQACGARIELMTVNRHDSVFGVVSHLPHILSYTLV-YDIATRIDAETFFHFA----ASGFRDFTRIASSPEMWKDIALANRETLLRYFQDSLESQDGEAIENFFKIARDARR 288
488 3.000e-48UniRef50_A0A2E3WG06 Bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase (Fragment) n=4 Tax=unclassified Gammaproteobac  ali  13  5.................................................................................DRVAVIGLGLIGGSFASGL-KQRKLAKHVSAFDIDARGLEFGLREGISAAGSVADACANAELVMLAVPVLSV-----QTILPDVPTGALITDVGSVKVPIIAASEAVYGEMLET------LVPGHPIAGSEQHGVRVILTPVTDPVATDRVRQLWRDLGSTVIEMSVEHHDSVLAQTSHLPHLLAYALVDSLSSQ----GDSMEVFQ-YAAGGFRDFSRIAASDPMWRDIFKANGPSVLAVLDRFRRMIADGDVEALQQVFQRAKE 276
489 3.000e-48UniRef50_UPI000D34DDB2 3-phosphoshikimate 1-carboxyvinyltransferase n=1 Tax=Saccharospirillum sp. HK-33 TaxID=2161747 RepID=UPI000D34DDB2  ali  12  9.................................................................................PRVLIVGLGLIGASFAKALRLSRSAQVFGMDAQPGVA--ERALELGIDARVDSIETVPEFDVLLLAVPVLAM-GSVLRSLQPYLRADTVISDVGSVKGRVVDAAREVFGDDLP-----AGFVPGHPIAGAERSGVDLILTPLSDPAAVALLTRLWQAVGAEVVSMSVARHDEVLAATSHLPHLLAFSLVDTLARES-DNREIFRYA----AGGFRDFTRIAASDPMWHDVFLANRDATLGVLRRF-----QSDLENLAGAIERGE. 270
490 4.000e-48UniRef50_A0A2P6W030 Uncharacterized protein n=1 Tax=Nanohaloarchaea archaeon SW_7_43_1 TaxID=1919221 RepID=A0A2P6W030_9ARCH  ali  10  6...........................................................................IMIDRTVAIVG-GTGKFGQHLGNHLDDGNEIIISGTNTD---EAEKIADQHGWDY-GSNKEAAKDADVIIVAVPI-AVTLEVIHEIGPEISDDALFCDVTSVKKKPVEAMKDYSG----------EVLGMHPMYAPSNPGQKIVLCPEKGKKWTE-MEEFWKQKGADIHITDPESHDEAMSLVQGLIHFSELVVAETIRKSGIDGEEMSNYSSPVYQLITDLTARMLNQPGLYGSIQAENPENIRIREKFIESAEDIRQLEAFGQKFEE... 264
491 4.000e-48UniRef50_G7W8H8 3-hydroxyacyl-CoA dehydrogenase n=2 Tax=Desulfosporosinus TaxID=79206 RepID=G7W8H8_DESOD  ali  12  6..................................................VAVLGGAGTMGSGIVQAVAQAGLQVLLFEADREAAQRGKGKIDKVVAKLAEK-------------GKISQADKQSLMDRIELDDFQRLQEADLVVEAVYENDLKKELFRQLDALLKPEVILANTSALSVTELAGVTKRPD-------KVIGLHFFNPA--PVMKLVEIVMGLTTSEETYQAAVSFCEQIGKKVIKA-KDTPGFLVNYLQIPLLNGAVAAYEAGLASAEDIDHPIGPLALLDLIGLDNALDVFTAMYEGTGDMRFWPRTLHKRLVQAGHLGRK............... 275
492 4.000e-48UniRef50_A0A1M3JU05 Prephenate dehydrogenase n=2 Tax=Burkholderiales TaxID=80840 RepID=A0A1M3JU05_9BURK  ali  9  9.......................................................................................GCGLMGGSFA-LAMKQAGLVQRVVGYSKSPTTTERARQLGVIDVEAPSAAVAGADIVLLAVPVSA-TEATLKAIRHLVTPQMLIMDVGSTKADVVQAASNAL------RDKVGSFVPAHPITGREVSGVEVILTPTTLTAQLQRAQEVWTQLGCRVTSMAPEAHDAAFAAVSHLPHLLAFTLVNSITG-QEQADTFLSLAGP----GFRDFTRIAASDPVWRDIFLSNRDELLQALERIEHAMRQGDAQSIEDMLTFASE 278
493 4.000e-48UniRef50_C0QJM0 TyrA n=28 Tax=Bacteria TaxID=2 RepID=C0QJM0_DESAH  ali  12  79........................................................................YRVVLR-------NSRIEQTGQMKQQAVKAGANVLIVGGAGQMGQFFAAMFRSSGYTVRNEVETLCRDTDLVLISVPIN-VTLKTIQRITPFVPPTAVLADITSIKQAPVDEMIKYFKGP---------IIGLHPLFGPSCSKQIIAVVPGRDNPACQWLVDQLTLWGAILVSSTAEEHDEIMGMVQALRHFAAFCFGQFLCQQKIDLEKTLEFSSPIYRLELGMVGRLFAQSGLYSEIIFATPQAYVSSVNEQITLVDNNDKALFEQRFSKIAD 353
494 4.000e-48UniRef50_F2I8T9 3-hydroxybutyryl-CoA dehydrogenase n=11 Tax=Bacilli TaxID=91061 RepID=F2I8T9_AERUA  ali  12  11.......................................................GAGSMGAGIANVFASNGYQVILRDIEDKFVQGGIDRISKFLD-------------GSVKRGKLDEAGKEESRIIGTTDLKD-FKDVDFVVEAVLEMELKQEVFKEVEGIVRDDIVLTNTSSLSITEIASALEDPS-------RFAGMHFFNPPQV--MKLVEIIYGYESSDETVAVVREVAESIGKETVTVHKDSPGFIVNRIMIPQMIEAIKVLEEGIATPEDIDKAMRYLELQDYAGVDIGYYVMEYFEQEYGDPRWTPPVTMKNMMRAGRFGK-KAGKGFYDYDEDGKQ 290
495 4.000e-48UniRef50_A0A1X0P8Y1 Putative short chain 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=Trypanosoma theileri TaxID=67003 RepID=A0A1X0P8Y1_9TRYP  ali  10  12..................................................SVVVWGGGTMGSGIAQISAQAGIPATIVDVSQERLDDSRKSIESSLTRLGRKRSP-----DDRNKIKVFVDETISQ-ITFTTDERLAASNGSLIIEAITESDVKKSLWKKVDGMAPKECIFTNTSSLSVMDQAAVTGRPD-------RFAGLHFFSP--VPMMKLVEVIKTEKTSQATVDKVLEYARKLGKQPV-MALDTKGFIVNRLLVPYQLEACRLVERGVASVEDVDHPMGPFTLADSVGIDVLKHITDQNPLY....................................... 270
496 5.000e-48UniRef50_A0A151ADM5 Fatty acid oxidation complex subunit alpha n=133 Tax=Archaea TaxID=2157 RepID=A0A151ADM5_9EURY  ali  13  13.......................................................GAGTMGNGIAQVCALNGYEVVMRDIEDEFVENGIEAIDDSLGRFVSK-----------GRIDESEVEATKGRITGTTDL-DDLADCELVIEAAVEMEVKQEIFADLETVTDEDVILTNTSTLSITTIASATDR-------EERVVGLHFMNP--VPIMEGVEVVVGEKTGAETIDLVHALATDLGKTTWESD-DKPGFVTNRILMPWINEGIRAYDEGVASKEDIDTPMGPLTLADHIGLDICLDASETLSEELGDRYKPAYLLKRKVDAGDLGKKSG.............. 278
497 5.000e-48UniRef50_A0A2M7W7X1 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=2 Tax=Proteobacteria TaxID=1224 RepID=A0A2M7W7X1_9PROT  ali  13  12.......................................................................................GVGLIGGSLARAL-KQSGFAGEVVGIEPNTAERALALQLGVRGEATVEEGVLGADVVVLATPVGPMERVGLACIAA-MDAGAVLTDVGSVKGVILTALEE------PALAAGIRLIGGHPIAGTEHSGVILTPTPHSDGGAQALVTAMWEAVGGQVETMEAALHDRILGATSHLPHVIAFSLVEALRRMNDGEG---GDLFRFAAGGFRDFTRIASSPPMWRDICLANGESVVEMIDRFRQAVDRGDADALEQTFVKAK. 282
498 5.000e-48UniRef50_A0A0C5CBD0 Prephenate dehydrogenase n=11 Tax=Bacillus TaxID=55087 RepID=A0A0C5CBD0_BACCO  ali  12  9.......................................................................................GLGLIGGSIALAIKKEHPEAKTGYDAKLEEMKMAKALMVVDDYVETIQDGVRGADLIILATPVL-VTEKLIGQLGQMLKENVIITDTGSTKESIMAKAQRLAGNNTV-------FIGGHPMAGSHKSGVTAALTPHEQDQRTEELKQWLKGTKANFITVSPEMHDEMVAVISHFPHVIAASLVHLVK----DADAEYPLLKRLAAGGFRDITRIASSSPMWADISCGNRENLIRLLDRWA-----KNLQEVKKALADNK. 265
499 5.000e-48UniRef50_O67636 Prephenate dehydrogenase n=13 Tax=Aquificales TaxID=32069 RepID=O67636_AQUAE  ali  13  31.................................................................................QNVLIVGVGFMGGSFAKSLRRS-GFKGKIYGYDINPESISKAVDLGIEGTTSIAK-VEDFDFVMLSSPVRTF-REIAKKLSYILSEDATVTDQGSVKGKLVYDLENILGKR---------FVGGHPIAGTEKSGVEVILTPTTDKKRLKLVKRVWEDVGGVVEYMSPELHDYVFGVVSHLPHAVAFALVDTLIHMSTPEVDLFKYPG----GGFKDFTRIAKSDPMWRDIFLENKENVMKAIE-----GFEKSLNHLKELI..... 288
500 6.000e-48UniRef50_A0A2P8EPU3 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Bacteria TaxID=2 RepID=A0A2P8EPU3_9FUSO  ali  13  7.......................................................GSGTMGRGIAQTFAQAGYEVYLCDVNELVAGRGKRRIE---ARLRDR----------VERGRISQEEMDRIMGNIRTGTKYLCLECDLVVEASVEMQVKKDIFRELEGICKKDCIFTNTSSLSITELSQGLDRP---------VIGMHFFNPA--PVMRLIEICVGMNTPQEIADKVSAIAEDIGKRPLQM-PEFAGFVVDRILIPMINEAIGIYAIDEAMRLGANHPMGPLALGDLIGLDVVLKIMQVLQAETGDPKYRPHPLLRKMVRGGRLGRK............... 269
501 6.000e-48UniRef50_A0A1V5KV11 Prephenate dehydrogenase n=1 Tax=Verrucomicrobia bacterium ADurb.Bin474 TaxID=1852931 RepID=A0A1V5KV11_9BACT  ali  15  11.......................................................................................APGLLGASLA-LASRERGMVGRVKVWARRGEVLEACRTRCDSVHADLGEGVADADMVWICAPVGRIA-GLAEQAAPFLKPGAIVSDVGSTKAELHAAIDRI------RMPEGCLYVGSHPMAGSEKSGLEYAPCFVTNRKATEAVEDFWTGLGMRVTRTTPELHDRMVAWLSHVPHLTAVGLSRTLAAAM--PEEWMQYAGP----GLRDTTRVASSVEMWRDILDQNRSQVIATLQGFERDLKAGEIDALVERLTRAK. 278
502 6.000e-48UniRef50_A0A2E5JWJ9 Prephenate dehydrogenase n=1 Tax=Chloroflexi bacterium TaxID=2026724 RepID=A0A2E5JWJ9_9CHLR  ali  14  15...............................................................................ILEKITIIGLGLIGTSLGLAIKKSNALTSTIVGHDLSKKHRSTAKKMGAKDEGDYKKAVQDSKLVIICTPVLSI-REVFENIAPHLNEGTVVTDTGSTKGQIHEWAKELL-------PPNINFIGGHPMAGREQSGPEAATADLASPEAIDAILGLVNIIGSNHYFVDPEEHDSYVAAISHLPFLLATTLMSMNSKSRG-----WREISKLAGSGFRDMSRLASGDPMHRDICLTNVNGISYWIDEFILEEIKKIMSGTSKEIED... 285
503 6.000e-48UniRef50_A0A183AQY3 Uncharacterized protein n=3 Tax=Digenea TaxID=256429 RepID=A0A183AQY3_9TREM  ali  13  24.......................................................GSGLMGSGIAQTAVQYGYSVNLVDSNQSAITKATSKINKNLTRLGEK---------KFAENKSEAQKYVDSNLHSFSDLEKAISQADLIIEAIVEMDAKHKLFRELDQRARADCYLANTSSLSLKEISTVISRKE-------RFGGLHFFNP--VPVLKLVEVIRTSETSDDTFQVLTQFAASLDKTPVACR-DTPGFIVNRLLIPYLIEAVALAERGDAMKLGAGYPMGPFELSDFIGLDTVKLVMRCPPM-----------LARLVAEGKLGRKTG--EGFFKY...... 290
504 7.000e-48UniRef50_A0A2G9YBA3 Prephenate dehydrogenase n=1 Tax=bacterium (Candidatus Ratteibacteria) CG23_combo_of_CG06-09_8_20_14_all_48_7 TaxID=2014292 RepID  ali  13  20..................................................................................................LALKKRQMAEQVIGVGRRQESLENAKTLGITYTLKVAEGFADAELIILAAPVNAV-LELLETGLAFLKDHRIITDVCSSKKVVVESAEKAL-------PSHLSFIGGHPIAGSEKNGAELTPTAKTQLPDFERIQTLWESLGSKVFSLTPDEHDRVLAVTSHIPHLLAVS-ASLLVEQAEIPNK-ENFIGP----GFRDLTRIAEGEPLWQHIFLTNSDHILENLTRLEKIIKKNDLEHLLKLLNSASQ 277
505 7.000e-48UniRef50_A0A075HLX9 3-hydroxyacyl-CoA dehydrogenase (PaaH, hbd, fadB, mmgB) n=87 Tax=cellular organisms TaxID=131567 RepID=A0A075HLX9_9EURY  ali  13  19.......................................................GAGTMGAGIAQVCAQAGWQTRLFDAFPEGLERGMNAINEFWNK-------------GIARGKTTSEQKAEANLTAIDNMAEAVSDVDLVIEAVPIMELKQQIFADLGRFSPAHAILTNTSGLSIGDIAKASGRP-------KQVIGMHFFNP--VPIMKLLELVQHDSISDETIATARTVGEAIGKTTILVN-DVPGFATSRLGVVIGNEAIRMLDIDTAMRLGYKHPMGPLELTDLVGLDVRCDILNNLAEAFDDESYLPHPLLVKLVEAGDLGKK............... 284
506 7.000e-48UniRef50_A0A2H6G5H2 Cyclohexadienyl dehydrogenase n=1 Tax=bacterium BMS3Abin11 TaxID=2005719 RepID=A0A2H6G5H2_9BACT  ali  13  9...................................................................................VVIIGVGLIGGSLARVLKAHDAVSQ-ITGVARSQETLDLALQLGVKAESDPVQAMKDADLVVLATPVSTIGP-ILSAIADVIPAHCVVTDAGSVKGSVATAAREALGDKIDC------FVPGHPIAGTENSGVRVILTPLNAETDIQLVQTMWEVCGARVVRMSLEDHDAMLGATSHLPHLLAYALVDFLSQQ----DRHEEIFTNT-AGGFKAFTRIVASSPMWRDICLANRHELI........................... 248
507 7.000e-48UniRef50_A0A2V3JAL2 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=unclassified ANME-1 cluster TaxID=1046933 RepID=A0A2V3JAL2_9EURY  ali  14  15.........................................................GVMGSGIVQVCTQAGYEVSVVGRSEESLKREQGKLKSSLSRLAEK---------GLLKQEEAGRIVDAVSANATTSLEEGARGADFVIEAVEELGLKQEIFRELDRICPEHAVLSNTSTFPITALAAATK-----GERAEKVIGVHFMNP--VPLMPGVEIIKSLMTSEETVRRTLDFVHSLGKQTVTV-KDSPGFVTSRMMCLILNEAASVEDIDKILRLSFNWPLGPFQLLDLIGIEIVVAVLNTIYNETGWERFKPAVLMTQMVRAGWTGRK............... 282
508 8.000e-48UniRef50_A0A1V5DZ88 Putative 3-hydroxybutyryl-CoA dehydrogenase n=5 Tax=Deltaproteobacteria TaxID=28221 RepID=A0A1V5DZ88_9DELT  ali  14  8......................................................MGAGTMGSGIAQIAVEAGFAVTVVDTEQAFVDRGIGGIKKFLEKKVAKGTYTQEQF-----------KAMDGRLSGTTDIKKAVEGAVMVVEAVFENDLKKEIFQKLDGLCPKEVILANTSTLSISVIAGVTKNPS-------RVIGTHYFSP--VPLMRLVEVIRGKETSDATAAKTVELCKKFGKTPIVV-KDIPGFIVNRFLCLIYNEAANMIDIDMAMKLGCNWPMGITEIIDLAGVDVCAFAMEAMYQMTGEERYKPSPLFAKMLAEKKLGRK............... 274
509 9.000e-48UniRef50_A0A085NL54 Tetraspanin n=1 Tax=Trichuris suis TaxID=68888 RepID=A0A085NL54_9BILA  ali  14  391.......................................................GSGLMGSGIAQV--QNGCRVSLVDISDEILSKSRKNMEVSLGRVAKKKFASDKQ------EAEKYTREIMQRITMTTSLANAAKDADLCIEAIVENDSKVNLFQTLEKEAPSKALVTNTSSLPLSEICASLKNKE-------RFAGLHFFNP--VPMMKLVEIVRALPTSNQTIDALAKYVEKL-KKTAVMCRDTPGFIVNRLLVPAGMEAIRLAERGDASKEDIDHPMGPFELFDYIGLDTCKFIVDGWHRFPENPIFFPSPMLDKLVEQASGER................ 659
510 9.000e-48UniRef50_Q0KEY8 3-Hydroxyacyl-CoA dehydrogenase n=99 Tax=Bacteria TaxID=2 RepID=Q0KEY8_CUPNH  ali  11  10.......................................................GAGTMGNGIAQACAVVGLNVVMVDISDAAVQKGVATVASSLDRLIKKEKLTEAD-----------KASALARIKGSTSY-DDLKATDIVIEAATENDLKVKILKQIDGIVGENVIIANTSSISITKLAAVTSRAD-------RFIGMHFFNP--VPVMALVELIRGLQTSDTTHAAVEALSKQLGKYPITV-KNSPGFVVNRILCPMINEAFCVLEIDEGMKLGCNHPIGPLALADMIGLDTMLAVMEVLYTEFADPKYRPAMLMREMVAAGYLGRK............... 274
511 9.000e-48UniRef50_A0A1W6BEX7 Cyclohexadienyl dehydrogenase n=1 Tax=Candidatus Pelagibacter sp. RS39 TaxID=1977864 RepID=A0A1W6BEX7_9PROT  ali  11  2.................................................................................RNILIIGCGLLGSSLVRKI-SQKKIAKKIFIYEKSQSNIAKIKKLRLPGTNSLKDGLVNSNLVIVCTSTSEYKELILK-INKTISPKTLITDVGSSKIESSKIIKKFL-------RRGINWIRSHPIAGSEVSGPEFIKDKKTSLKNLKFLISFWKKIGSKTVIMNPEKHDKVFSITSHLPHLIAYNLV----KSAQDFEKILKFGLIKYAGGLRDFSRIAASNEMWRDIFFDNKANFIKNLKSFKKDINSKNNKSILKKLSQTKK 278
512 9.000e-48UniRef50_A0A1F9E058 Uncharacterized protein n=1 Tax=Deltaproteobacteria bacterium RBG_19FT_COMBO_46_12 TaxID=1797850 RepID=A0A1F9E058_9DELT  ali  9  1...........................................................MGHGIGQTFALGGYEVTLNDISDEVLNKAVQQIRSNLDTFVE----FGITTPEGAKEAIS-------RIKTNKNLKETARESDFVVEALPVMDLKKRIFKELDEYCPSHTVIANTSGLSLTEMASGIKRQDQAVIA-------HWWNPPHI--IPLVEIVKGRYTSELTVDLVYQLLVSVGKKPVKILKEAPGFLGNRLQFALYREALYCLKEGIASAEDIDTALGPLETSDFGGLDTYLHIAK--YLFKEIDREPPEFLREKVRQGKLGVKTGEPEEAEKKIKERDR 287
513 1.000e-47UniRef50_A0A1F8P8Z0 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Bacteria TaxID=2 RepID=A0A1F8P8Z0_9CHLR  ali  12  12.........................................................GQMGGGITQVCAQSGYPVTVSEVNEALLKKGLSSIDAALTRSVQKEKISQQD-----------KDTAIARIKGTTNMGE-FADCDMVIEAAIENDLKKRIFGELDKVCHRNAILTNTSCLSIIDMAVATKRPD-------KVLGLHFFNP--VPVMKLLEIVRTVATSEETLETGKNFGRSVGKTIVLAQ-DAPGFIVNRLMVPQILNAIRMLESGVATREDIDHPMGPLALADLVGLDTLLFIANGIYDEFRDTQYAAPTLLKKMVTAGWLGRK............... 274
514 1.000e-47UniRef50_D9PUD5 Predicted prephenate dehydrogenase n=19 Tax=Methanobacteriales TaxID=2158 RepID=D9PUD5_METTM  ali  14  16...............................................................................................IARFLKKE-GLRVIITGRDHDAG-MEAASRIGVEYCGDNVQAASRADVVVVSVPI-DVTADVIREVAPQVRKGGLLMDVTSVKEEPARVMEESIG-------DGAHHLPAHPMFGPRVSGQVVVLTPTQENPWVDTVIEFLEKHKARVIVTDPATHDRMMSVVQVLTHFAYISIASTLEAEGVDIRESRKFASPIYNLMIDTIARIVAQNPLAYSIQIHNPDSFLRTASELNEMLSDGRMDEFVSRM..... 262
515 1.000e-47UniRef50_A0A2A4VZM6 Bifunctional chorismate mutase/prephenate dehydrogenase n=2 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A2A4VZM6_9GAMM  ali  14  78.........................................................................DLIEDVIRRIIRESYKSQNTQRVISSNTESKEILIVGGKGQLGQLFGDLFEKNGDKISLDSEEALKKADLVLISVPIN-VTLSVITEIAKVLKPNCTLADVTSIKNQPVQEMLSQYQGA---------VVGLHPMFGPDIEKQTVAVCHGRLKENYQWLLDLLSKKGINLVDVEAKIHDDLMSIIQVLRHLSTVAYGNHLRHEDIDLNKILELSSPIYRLELIMVGRLFAQDPLYSDIIFSDKNNIIXRISETLSFVENDDKQSFIQSFNETKE 364
516 1.000e-47UniRef50_UPI000C9A1F3D prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Burkholderia pseudomallei TaxID=28450 RepID=UPI000C9A1  ali  15  4..........................................................................VVSGFYFDKLVIFGVGLIGGSLAALREGASGGRREVVGVGRSSASIGRALALRVDDDAQLRDALAGADLVLLAAPVAQTGP-LLARIAPFLDASTIVTDAGSTKSDVVAAARAALGT------RIGQFVPGHPIAGRESSGVNVVLCPENAPDALARVEAMWRAARADVRAMSAEQHDRVFAAVSHLPHVLSFALVEQILGES---DAELKFS--YAAGGFRDFTRIASSPEMWRDVCLANRAALLDELD....................... 263
517 1.000e-47UniRef50_A0A0P8Y3P5 Cyclohexadienyl dehydrogenase n=2 Tax=Pelagibacteraceae TaxID=1655514 RepID=A0A0P8Y3P5_9PROT  ali  12  1...............................................................................MFEKICIIGCGLIGSSLRDVYNSKISKSVTVFDNSREVIEIIKKENLCNNVSKDIQSAVKNSDLVIIAVPLSAYK-EVLLSAKDSFKKDAIVTDTGSVKKEVNKIFKN-------LNLKDVYWLASHPIAGTEESGPNIICNDQNSKEKVEKLKKFWEFLGSKVKFMSIEDHDYILSLTSHLPHAVAYNIVLTAINTDEKFDEIIKYS----AGGLRDFTRIASSDPMWKDIFIDNSENILKILEQFSKNIDEKNGDKLLKMFSSTK. 278
518 1.000e-47UniRef50_A0A0P8YJD4 3-hydroxyacyl-CoA dehydrogenase (Fragment) n=1 Tax=Nitrosopumilus sp. PRT-SC01 TaxID=1527301 RepID=A0A0P8YJD4_9ARCH  ali  15  1..............................................MTIKNITVLGSGVMGHGIAQVSATAGYNVVLRDIEQEFLDKAMKKVKWSIDKLVSKEKISKEEG-----------DAIFARITPIVDLNEAVKDAELIIEAVPIMDLKKKVYAELDKAAAPEVVFANTSTLPITEIANTTSRPE-------KFIGIHFFNPPQL--MKLVEIIPGEKTSQEVIDLTQESVKSVNKIAVICRKDVPGFIINR-LFIPMVTGATLEEIDSAVKFKLGFPMGIFELADFTGM.................................................... 239
519 1.000e-47UniRef50_A0A151A8D3 Fatty acid oxidation complex subunit alpha n=444 Tax=cellular organisms TaxID=131567 RepID=A0A151A8D3_9EURY  ali  11  7.......................................................GAGTMGHGIAQIAAQAGNAVTIRDIDNAILEDGLDAIESNLQ-------------GGVDRGKVSQEEKATTRIGTTTDLEEAVDGADLVIEAVPEDGIKHDTFEEVKAAAPEEAVLANTSSLSVTEIASVLDRPGRA-------IGLHFFNPVHI--MGLVEIVVAEQTDEATVAFAEGFVEEIGKEPVTVR-DSAGFASSRLGVALGVEAVRMLETDRAMELGYNHPMGPIELTDVVGLDVRLDILEYLQEELG-ERFRPPQLLRQKVRAGKLGRK............... 271
520 1.000e-47UniRef50_V5AHZ0 Arogenate dehydrogenase n=1 Tax=Betaproteobacteria bacterium MOLA814 TaxID=1408164 RepID=V5AHZ0_9PROT  ali  12  13.......................................................................................GCGLIGGSFALALKAVMP-HLVVTGVGRQLSSLQTAKTMGVHASTDMAASVASADVVLLGVPVGAI-HSTLQHIAPHLQEGALVMDVGSTKADVVAMAQATLGKHLP------NFVAAHPIAGKECSGVRVILTPVTHAAALERADALWAACGAHVHTMDATEHDRVFAAVSHLPHLLAFAYMNGVAD-----DQTLALAGP----GFRDFTRIAASSPVWRDIFVANREPLLAQLAQFEMA.................. 253
521 1.000e-47UniRef50_A0A2K2VWD1 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Desulfobacteraceae bacterium TaxID=2049433 RepID=A0A2K2VW  ali  11  2..................................................................................................IEDKDIHVGIIGGLGKMGRWFHRFFAELGYQVSTTPEDLAKTCNLVLVAVPLQH-TVEVVRAIGPLVQNDALLMDLASLKSEVVSTMLEVSAAS---------VIGTHPLFGPGVTGQTVVMCPGRGQWWQEWLQGVLVEGGARVEVVTPEVHDYYMAVVQGLTHFSTLALGLTIDSLGVDIKNLKRFATPAFHRRLVEITHLLSQDALYAAMPMLNSREFERIILDLKGVIAQKDIDEFIRLFDRAR. 256
522 1.000e-47UniRef50_A0A2J6WZQ4 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=5 Tax=Aquificales TaxID=32069 RepID=A0A2J6WZQ4_9AQUI  ali  12  28.....................................................................................................KKEGYKGKIYGYDLNENRVKTALELKAEGFNSLENIWESVDLVVLSTPVKTF-LDIAKTIKPFLNQDTVVSDVGSVKGDLVLKIHEVLKPHT--------FVGVHPIAGTEKEGIELILTPGEDTEKVEKVEKLWKDLGSKTEVMDPHLHDFVFASVSHLPHAIAFSLVDSLITLSKESGDLFKYPG----GGFRDFTRIAASSPIWKDIFLENKENLLQSVQKLKDAIEKEDENKIIEILSESRE 284
523 1.000e-47UniRef50_A0ZB48 Cyclohexadienyl dehydrogenase n=18 Tax=Cyanobacteria TaxID=1117 RepID=A0ZB48_NODSP  ali  11  26.......................................................................................................QNITIIGGLGRMGKLFREQLSSVGNNVSVLEHEDLSQAELVLVSVPIER-TVEVIKRASQYLSPNTALCDITSIKTQSTQAMLEHHSGP---------VMGLHPMFGPNIKGQKVVVCPGRNDDSFQWLLNLIKNQGGELITCTPEEHDQMMVIVQATQHFSRFSLGVFLTEAEIDIERSLSMSTPSYRQEIEILQRLFAQNPLCVDIILATEESLANTYSRLAMLVAKKDRAALIQEFENAQE 276
524 1.000e-47UniRef50_A0A226F0N4 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial n=4 Tax=Hexapoda TaxID=6960 RepID=A0A226F0N4_FOLCA  ali  13  48.......................................................GGGHMGSGIAQISAAAGNFVTVADVNENALSKSRQRMEQRLVRFSKKL--LKDDAEKIHKQVETV----LSKIQFTTDIKNAVKQCDLVVEAIPEDELKHKLFETIDKVAHEATIVTNTSSIPVHELAQALSS-----KRKEQFAGTHFFEPVTV---KLLEVVRIPETREEVFHKVMEWGRFIGKVPVVC-KDSPGFIVNRLNIPYLINAVSMFERGDASYQDIDVAMGPFELADYVGLDVIYMILIGWERFADVERFKPNTIKEMYKQGRFGKK................ 320
525 1.000e-47UniRef50_UPI000A0308FB hypothetical protein n=1 Tax=Alicyclobacillus pomorum TaxID=204470 RepID=UPI000A0308FB  ali  11  48.............................................NSPAGVIGVVGAGTMGEGIAQVALQSGYSVVLFDIQADVLQRAVSDIHKKINRL-------------VDKGKLTREAADGAVARLAASDIAHLAQAQLVIEAVPERNIKRDIFRQLEQVCSKDTILTNTSSLSVTVIGAGCQYPG-------RVVGMHFFNPA--PVMKLVEVVVGDDTTSEVVDAVVRLARSFGKHPIVC-KDTPGFIVNRVARNFYGEALRIVGEGTADPADVDWLMGPFALMDLIGIDVNLDVTAVYHAYHEEPRFRPHALQARMVAAGRLGRK............... 323
526 1.000e-47UniRef50_UPI0002DAA138 prephenate dehydrogenase/arogenate dehydrogenase family protein n=2 Tax=Oxalobacter formigenes TaxID=847 RepID=UPI0002DAA138 :  ali  13  4................................................................................FKKIVICGVGLIGGSFALALKKS-GFKGKILGLERSPDILERAHALGIVDQTGLEETLRDADLIVLSVPVAQ-TGNALKMILPYWHDGLIVSDTGSTKTDVVAMARDVLG------EKIAQFIPAHPIAGSEMNGPEIAALPENSRADVERLADVWERCGAIIHHLTPENHDTVFATVSHMPHLLAYGLVDYVANHPKS-----DLFFQYAASGFRDFTRIASSPEMWRDITLANRKQLLVELDA-----YLKEIELIRDLVDKAD. 267
527 1.000e-47UniRef50_A0A2D6EYI6 Prephenate dehydrogenase n=1 Tax=Candidatus Woesearchaeota archaeon TaxID=2026803 RepID=A0A2D6EYI6_9ARCH  ali  13  3........................................................................................................KVAIIGGRGKMGRMFARAFRKQGHTVKLTPAQAAAKGDLVIITVPIRD-TVNVIKKIGKHVRKGAILTDFTSVKVRPCKAMKKYSKAS---------VVGSHPVFGPGLKNQHFVLCPVRGSHA--WYKQALKKMGLRVSTMTPEAHDRHMAIVQCLSHLSNFSFAHAMKQLKYNPNKEV-LTSPIYRVKLGIVRRALDTDALYTDIETENPYAFKKATDTLEQAIREEDKKGIKRIILQCQK 248
528 2.000e-47UniRef50_E1YHF2 Uncharacterized protein n=1 Tax=uncultured Desulfobacterium sp. TaxID=201089 RepID=E1YHF2_9DELT  ali  11  1..................................................................................................................MGRWFKDFFSAAGHNVTTDIADVAKECDVVILSVPIDAAI-SIAKDIGPLMHKEQLLMDMCSLKEEIVKSMTDNTKA---------EVLGTHPLFGPSIKGQNVILCPGRGERWLKWIENECSLRGAVVCVMDPLTHDRHMAVVQGLTHFTTICMARTLQKMNMDACNVLSCSTPVFKINYNLIGRLFAQDDLYKSLINKNKEIFISAMDEGKDALLSGQDESGTMFMENIRE 240
529 2.000e-47UniRef50_A0A2K3D509 Uncharacterized protein n=2 Tax=Chlamydomonas reinhardtii TaxID=3055 RepID=A0A2K3D509_CHLRE  ali  11  10.......................................................GGGQMGWGIAQVIASRGMNVLLNDTNPLALERGLGQLKKALERLVKKDSMLPDD-----------AAATLGRIHTSHNGLESVRGADFIIEAVAEDELKKEVFRKLDRATRVETILANTSSISITRLASVTSKP-------HRVVGMHFMHPA--PVVPLVELAKGMHTSQQTYEAARSLAESLGKSVC-VSQDRPGFLVYRLLMPLVNEAFFLLSENVGSAEDIDRSMRLGTNMDNIGLDTCLSIMRTLHSQFADSKYRPCPLLVQYVDAGLLGAK............... 275
530 2.000e-47UniRef50_A0A0L0DHH6 Hydroxyacyl-Coenzyme A dehydrogenase n=1 Tax=Thecamonas trahens ATCC 50062 TaxID=461836 RepID=A0A0L0DHH6_THETB  ali  11  25..........................................TRSSLAHASGIAAVSGIMGAGIAQVSAHHGKDVRLVDLSEENLARGKAAIEGSLKRVLKKEADVDAAVADV-----------MARITFTSSMEEALKGSDLLVEAVYEDETKRQIFGVAQQYADDECIFTNTSSLSVNSI--------CNGVRPERFGGLHFFNP--VPMLKLVEVIKTDETSDATADALREFAAEVGKEPIVC-KDTPGFVVNRLLVPYLQSAVDMMERGDASKEDIDKPMGPFELLDVIGLDTAALIINSW-VRTHGDTFNATPAIDKLVSDGKFGR-KNGEGFYKY...... 313
531 2.000e-47UniRef50_A0A2H5YNP8 3-hydroxybutyryl-CoA dehydrogenase n=4 Tax=Bacteria TaxID=2 RepID=A0A2H5YNP8_9BACT  ali  11  12.........................................................GIMGGGIVHVCAVHGYDVTVVEADEERLQKGLDGLYRGLAR-------------EVERGRLTEEQLQRARISGSTDLN-AVADCDLVIEAVVEDDVKKALFAELGRICRPETILTNTSSLSLSALAGASRRPD-------RVIGIHFFNPPTV--LRLVEVISSESTSAETIEAAMEFCDSID-RLTVRTVDSPGFIVNRLLVPFIFDAIRMVESGIASAEDIDHAMGPIATADLIGLDTLLQISESMFEAYGEPRFKAPTSLRRLVSLGHLGRK............... 274
532 2.000e-47UniRef50_A0A1G1J321 Uncharacterized protein n=2 Tax=unclassified Candidatus Omnitrophica TaxID=1047005 RepID=A0A1G1J321_9BACT  ali  13  3...............................................................................LFNRVAIIGVGEIGGSIGKDL-KARGLAKEIIGIGRRRSSLIKARTAGAVLVDRIGNGVKDADLIILATPVGRMA-ELGKKAALSAKEGAIMTDVGSTKGMIVRSLEKIL-------PEKVRFVGSHPMAGSEKGGPLITRTKNTDEEALEIVKKFWKRLGANTIEVTLAEHDRIVAKISQMVHLVASCLI-------IANKDVLRYA----ASGFRDTTRIALSDPLWRDICLTNNKNIARSLDELIVILRKEKAAHIERMLGKARE 275
533 2.000e-47UniRef50_A0A0Y5PVE0 Oxidoreductase n=85 Tax=Proteobacteria TaxID=1224 RepID=A0A0Y5PVE0_NEIME  ali  12  24.....................................................................................................KRQGLVRTVTGIDTDRDNLERALERGVIDRASDADSIGGADLVLIATPVATV-PAILTALRPVLPEHTWISDVGSTKSSVIEAFRRCLPDRLH------HCIAAHPIAGSDRSGRKLIITPHGGEDGIALVEELWHAVGAEIYTMDAQRHDAVFAAVSHMPHLTAFAYVHQILDHPDGQEYLK-----FAATGFRDFTRIASGPAVWADICLANKDSLLKQLDVLANILTTDDREALYRYFEEAK. 280
534 2.000e-47UniRef50_A0A2S0VL99 Bifunctional chorismate mutase/prephenate dehydrogenase n=2 Tax=Catenovulum TaxID=1172191 RepID=A0A2S0VL99_9ALTE  ali  9  38..................................................................................................LSADPKRIAVIGGAGRLGSLFVKWFRMSGHTVTVVDKALVQGCQLVLVSVPIN-LTEQTIEQLAPQLDSSVVLADVTSVKVKPLDAMLKAHPGP---------VVGLHPMFGPDMDDQVIVHCAGREQDKYQWLLDEFKQQGAKLHCTSAESHDKAMAFIQVMRHFTTFVYGMLLQREAPELRELIAISSPIYRLELAMVGRLFAQDPLYADIIFANQDNFMQAYDKGLELLDMGCKEEFKREFN.... 289
535 2.000e-47UniRef50_B4CW53 Prephenate dehydrogenase n=1 Tax=Chthoniobacter flavus Ellin428 TaxID=497964 RepID=B4CW53_9BACT  ali  13  3..................................................................................RLAIIGPGLLGGSIALAARRAAGFHVAVWARRAEAVAELQKRALAEVASTDLAEVVHDADIVVLAVPIG-IMGSLARQIASLVPSRAIITDVGSCKGPVVEELSPIFAQRGR-------FVGSHPMAGSERTGLECIVTPRTDAEAVTTIHNFWQTLGGRVLELSPAEHDEIVAMVSHFPHLLAAALVNLVAEKN---ATALEFAGP----GFRDTTRVASGPPMWTEILRSNHTAVRASVEAMIEKLRE............... 251
536 2.000e-47UniRef50_A0A239T947 Arogenate dehydrogenase n=2 Tax=Megamonas hypermegale TaxID=158847 RepID=A0A239T947_9FIRM  ali  16  10.......................................................................................GVGLIGGAFGMALKNKLGDDIFITGNTRTQKSIDNAERLGAKGYLDPIECVKGADIIYLSTPVLQIVP-LVEKILPHLKKGAILTDAGSTKSYIARQIMNML-------PENIYYVAGHPMTGREKSGVVIVKDTKAPAEVLQKVVDLIKLTEANITTLTLEEHDRCASIISHIPHIVAAGLVNLLDKNPNDLEACITLAG----GGFKDTTRIASSNAMWADVCISNAEPIIEHLSNMITAIAKKDRQTIHDYFVESK. 279
537 2.000e-47UniRef50_A0A2W4HRN6 Prephenate dehydrogenase n=2 Tax=unclassified Candidatus Margulisbacteria TaxID=2211321 RepID=A0A2W4HRN6_9BACT  ali  12  4.................................................................................DQVTVIGLGLIGGSLA--WKIKDKKLARVVGYARREETIKEALDKGIEGTTDLINSIKNSNLIMVCTSIDSVT-DIVKEISVYLRSDAIVVDVGSTKKKIVYELSNSL-------PEGVTFIGGHPMAGSEKSGIKFILTPYKTPDNQKIIKLFIEKLGMKIEYLSPDEHDLAVAAISHLPYLMAATLVNTI-----GTHENSAIFLRVAASGFKDTTRVSSSPSLWGDVCVTNKDQILDNLNYMESLIKLNKEKELLDYFENA.. 275
538 2.000e-47UniRef50_UPI0006C8F9DF prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Thermanaerothrix daxensis TaxID=869279 RepID=UPI0006C8  ali  14  13.......................................................................................GLGLMGASLAAAL-RPHCRSIFGVDQDREALEWCEAQRWIDRGYQHPEQAVAQADVVVLATPVRAI-LDLLDIIPTHLSPGTILTDIGSTKVAICQKMQE--------LPPHIHTVGGHPLCGREVSGYVLVPTPNTSGNALDLLTQMVTAIGARPLLLNAETHDHLVAITSHLPYLLACALTQTTARVP----DPDGLLRQLTASGFRDTSRLAGSDKMMLDILQTNRENILKGL-EMYLQTLQGLINTLVEEREE... 268
539 2.000e-47UniRef50_A0A1I2MT41 Prephenate dehydrogenase n=3 Tax=Desulfotomaculum TaxID=1562 RepID=A0A1I2MT41_9FIRM  ali  15  9.......................................................................................GVGLMGGSMA-LALNERKLAQTIVGCDINKENIKMALAAGIHESAGLEAAVRNAELVLLATPVGT-TTAILCEIKDYLNPGTVVTDMGSTKQTVVEQAEEIIQGGW--------FVGGHPMAGAETSGFDLTPTCATNPSALNFVRQLAEAIGALVVEMPPSRHDLVAATISHLPHLVAAALVDAVALMPDSEGALA-----FAAGGFRDTTRIAASPEMWRDIFLSNHDALRRAITEMELAIKNRDSDKIYEILSHAS. 274
540 3.000e-47UniRef50_K4CGY4 Uncharacterized protein n=20 Tax=Mesangiospermae TaxID=1437183 RepID=K4CGY4_SOLLC  ali  12  11.......................................................GAGQMGAGIAQLAAVNGVDVWLYDLDSEALTKAQKSISNNIQRLLTKGQIS---------QATSVDAVKRLRCSSRLDDLQSV---DIVVEAIVESEVKKSLFANLDKIVKSSAILANTSSISITRLASATSRPS-------QVIGMHFMNPP--PIMKLVEIIRGADTSEDTYCATKCLAERFGKTVI-CSQDYSGFIVNRILMPMINEAFHTLYTGVATKEDIDHPMGPLELADFIGLDVCLSIMKVLQAGLGDDKYAPCPLLVQYVDAGRLGKKR.............. 276
541 3.000e-47UniRef50_UPI000880E28E prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Sporolituus thermophilus TaxID=608505 RepID=UPI000880E  ali  14  11.......................................................................................GLGLIGGSLALALKKYTE--HTVWGCDISPDTLKQALEAGARAGTQIHEVVNGADVVIFCLPVSRISAAV-AEAAPYFKPGTVITDVASAKGCLLATV-------PGLVPREVTYIGGHPMAGSEQSGFTYILTERVNDEAMARLRQIITAIGAIPVVMDGEIHDMVVAQISHLPHIMAAALVNLAGSGKHS-----QLSLSLAAGGFRDMTRIAASNPLWVDICLANRTQIISSLKQL-----QEVLQQVARNLEEND. 265
542 3.000e-47UniRef50_I9DL75 Prephenate dehydrogenase n=8 Tax=Sporomusaceae TaxID=1843490 RepID=I9DL75_9FIRM  ali  13  23....................................................................................................KKQCGEELRVTGVDYEQETLELAVQRGAVDTNDLKKGVEQADIIFLCTPVLQIIP-IVEQILPYVKVGGILTDVGSTKGFLAEKLL-------CMMPSGVHYVSGHPMTGIERSGIILIPEASTSPEAVEIISQTLTWTGARITTMDLADHDQCAAIISHIPHVVAAALVNLLGKYPA-LEESFKLVG----GGFRDTTRIASSNAMWADICLTNSQPITQSL-----LQVKELLDEMIQAVEKADR 267
543 3.000e-47UniRef50_UPI000408FD8A 3-hydroxyacyl-CoA dehydrogenase family protein n=1 Tax=Desulfotignum balticum TaxID=115781 RepID=UPI000408FD8A  ali  11  14.......................................................GSGVMGRGIAQVSYTAGYQVILVDKEQEIVDSSIKRIENSLLKLSQK-------------GRLDQKLADEAASKIVTTELSSLSQCDLVIEAVFENEIKKTILKELDQVCSQQTILANTSSLSISKLGSGLSRMENI-------VGMHFFNP--VPIMNLVEIVKTVKTSTQALESVVEFVKSIQKKPVVVR-DQAGFVVNYILTPFLFDAVTVEEIDNAFRFGCGHPMGPLALCDMIGLDIL--VTAGNKMFEEDQKYAPPPLLKRLVDGDFGIKSGR............. 281
544 3.000e-47UniRef50_A0A0E2UDT8 3-hydroxyacyl-CoA dehydrogenase n=19 Tax=Firmicutes TaxID=1239 RepID=A0A0E2UDT8_9STRE  ali  14  22..................................................................LFAQNGYRVILRDVEQRFIDTGMQRITKFME-------------GSVKRGKLSQEEMDEARITTTTDLKD-FKDVDFVVEAVIEMDIKQSVFKELEGIVREDVILTNTSSLSITEIASALKNPS-------RFAGMHFFNPAQV--MKLCEIIYGLETSDETIAIVKELAESIRKEVVIVKKDVPGFIVNRIMIPQFIEAIKVLEEGIASKEDIDHPMGAFELQDYAGVDIGYHVMNYFEKEFGDNRWTPPTLLKNMIRAGRNGKK............... 276
545 3.000e-47UniRef50_F9VMJ3 3-hydroxybutyryl-CoA dehydrogenase/crotonyl-CoA dehydratase n=76 Tax=Thermoprotei TaxID=183924 RepID=F9VMJ3_SULTO  ali  15  1..............................................MKLEKVLVVGAGTMGHGIAELFAIAGYEVYLSDISQEILDNALNKIKWSLDKLQEKGQLKESTSNIISR------------IKTVVGLNESVNDADFAIEAAIERDLKRQIFSKLDELLPTHAILTNTSSLSISKIAEATKRPE-------KVVGMHFFNPPVL--MQLVEVMKGEKTSDETAKTTYELAKKLGKIPIMINKDVPGYVVNRILGILQKGIADYLTIDAVAKYKLGFPMGVFELLDYTGIDV.................................................. 240
546 3.000e-47UniRef50_A0A1G9SL76 Prephenate dehydrogenase n=4 Tax=Comamonadaceae TaxID=80864 RepID=A0A1G9SL76_9BURK  ali  9  9.......................................................................................GCGLMGGSFA-LACKRAGLVKRVVGYSKSPSTTERARQLGVIDVEAPSAAVAGADVVLLAVPV-AATEATLKAIRHLVTPTTLIMDVGSTKQDVVQAARDAL------RERVGSFVPAHPIAGREVAGVEVILTPTTLTAQLQRARALWSALGCRVSSMAPEAHDAAFAAVSHLPHLLAFALMGAI-QSQPDAERLLALAGP----GFRDFTRIAAGDPLWRDVLLANREQVLAQSQQFAAA-----LDMLQQAMRAGD. 265
547 3.000e-47UniRef50_A0A2J0LDD4 Uncharacterized protein (Fragment) n=1 Tax=Candidatus Omnitrophica bacterium CG12_big_fil_rev_8_21_14_0_65_50_5 TaxID=1974754 Rep  ali  15  7.............................................................................RFLFDRVVIVGVGLIGGSVGMAIRK-HKLARKVVGLSRRQASLVKGQKMGAEGWTDVAQAVRGADLVIMATPVEGIVK-MLEQINPHVRKHCIITDVGGTKAEVIAKAQNVLSNPS-------NFVGAHPLAGSEKKGVEFILTPVTNPAAKDKIKILWSKIGGRVKQMPPEEHDEILAFVSHMPHLMAYSMVESIPDAFLSY----------AAGGLRDTTRIAAS........................................... 229
548 3.000e-47UniRef50_A0A1I3SMF9 Prephenate dehydrogenase n=7 Tax=Thermoactinomycetaceae TaxID=186824 RepID=A0A1I3SMF9_9BACL  ali  13  3.................................................................................ETVAILGVGLIGGSLALSFKERTCLRVIGFDLYEEDLAFAKAAGAIDEGYTKLLPAVQDADYIFIALPVDKIKQAILTELP--LKPNVMISDVGSTKAEIVQKGRAL-------NQQGITFIGGHPMAGSHRSGFKYVLTPDTPNESVEQLRQLIEKTKAQVVLMDAEEHDRVVGAISHLPHIIASGLVYQVGKYSEENEW----FHRLAAGGFRDLTRIASSHPMWRDILLSNVRELIEQMKEFQLAIIRRDAEKIEHLFDRARR 279
549 3.000e-47UniRef50_A0A140LBE1 Prephenate dehydrogenase n=3 Tax=Thermoanaerobacterales TaxID=68295 RepID=A0A140LBE1_9THEO  ali  13  4.................................................................................EKAAVVGLGVIGGSLAKA---LNAAGIEVMGIDMDDETLLKARKDGVISHDSFNEPLKKADVVFLAIPVMDIVP-VMRRLAPFFKKDAVVTDTGGTKRFLVNSI-------NFELPEGVEFIGGHPMAGSEKSGYILTPTPENTKTSVETLKKVVSKIGAIPYVVAAEEHDRIIAAVSHLPQVVATSLAAAIGELDEGGEWLK-----LAGRGFKDTTRIAASSFIWRDVFITNGDEIIKMIR-----LYEKKLEELAEAIESKDE 271
550 3.000e-47UniRef50_A0A1X7HJD6 Prephenate dehydrogenase n=3 Tax=Paenibacillaceae TaxID=186822 RepID=A0A1X7HJD6_9BACL  ali  14  13.......................................................................................GVGLIGGSLALCLKGKPGITVTGYAHTQDYADQVIAREVVDQVTLSPEEAAWDADFIFLCVPVGSL-EHYITLLSGLLKPGCIISDVGSTKASITDCAE-------RLVLKDACFIGGHPMAGSERSGVKYVLTPNVPADKVDSLSVLLSHTRAHIVTVEPQLHDQIVGAISHLPHIIAVALVNQICSYNED----NPLYQTLAAGGFRDITRIASSDPVWRDILLNNRKVMMPLLRDWNDGILQ-----FMAMLESQD. 269
551 3.000e-47UniRef50_A0A2G4G541 Uncharacterized protein n=4 Tax=Opitutae bacterium TaxID=2026771 RepID=A0A2G4G541_9BACT  ali  14  21..................................................................................................LAAKKRNISAEFSCWSHSPASLTFWSSLGVSVHTSLKDSVKDADLVIIATPVDKIA-ETFVALSPFLKPGCLISDVGSIKGAVLKAA--------SFLPPSVNFIGSHPMAGSEKAGAKITPGPRDPTDSVQKIERFWQSLGSKTFLCSAEKHDEIVAAISHTPHASAAALILAVKNLP-------GFKQAAVGAGLKDSTRIAAGEELWVGILLANAKEVEKQTTELRTIIERGDAAALSKILEAAR. 274
552 3.000e-47UniRef50_A0A1G1MUB4 Uncharacterized protein n=7 Tax=unclassified Candidatus Omnitrophica TaxID=1047005 RepID=A0A1G1MUB4_9BACT  ali  14  2..............................................................................ILFDTVAIVGVGLIGGSLG-LAMKHHGLVKKIIGIGHRRESLAVALEKGAIDEGYLEDKLMDADVVILATPVNEIKMSI-PRIAKIIRKECIVIDVGSTKAEIVKAAEKC----------RLNFVGCHPLAGMEKRGVELIAAKKTRKEAVAKVKTLWEAVGAHTKTMDARSHDRVLAFVSHLPHAVAFCLIDCIKPGYLGF----------AASGLKDTTRISMSDPVWKDIFLTNRAELLKAIKDFK--RSLGRLESFVNA...... 255
553 4.000e-47UniRef50_A0A142XCM4 Cyclohexadienyl dehydrogenase n=2 Tax=Gemmata TaxID=113 RepID=A0A142XCM4_9BACT  ali  12  2...............................................................................LFDQITIVGVGLIGGSVG-LAARARGVAGRVVGVDRDEATIAKAVALGAAGTTSLAEGVANSSLVVVCTPVDRITEVILAA-APHVRPGTRFTDGGSTKAGIVSALQGKL-------PANVEYIAAHPLAGSEKAGVTVVIISKFGADWERTVARFWEALGSRVVLMNAEEHDRTVAVTSHLPHAVASAVA------GVTPTEWLRLS----AGGFRDVTRVAAGDPLWAAIFEANRDATLSALAAF-----TDRLAEFRKLLEAGD. 261
554 4.000e-47UniRef50_A0A1E4ZNV7 Uncharacterized protein n=1 Tax=PVC group bacterium (ex Bugula neritina AB1) TaxID=1868283 RepID=A0A1E4ZNV7_9BACT  ali  12  4.................................................................................QHVAIVGLGILGGSLAQALKK-KDLVRKITAVTRSQKTLDMALEAIDRGIVKIDETLRDCDLVILCTPVSQILKDIVS-LSKVLSSKTIVTDVGSTKQIIVSCGDQYLSR----------FVGAHPLAGSEKSGLKITPSEKKDKDALKLVKDFWIDLGTKVHFLNPREHDNIIAHTSHLPHFIAASLVQSLSAKEE------KFVSKGYW----DTTRVASEVKMWRDIFSQNREALLKEMDNFKSMLEEDKMDALEGWLEKAK. 269
555 4.000e-47UniRef50_A0A1Q3T3P0 Uncharacterized protein n=1 Tax=Chloroflexi bacterium 54-19 TaxID=1895928 RepID=A0A1Q3T3P0_9CHLR  ali  18  7.......................................................................................GLGLIGGSMGLALRNWAKTEEELVGFDAKGKQKALADKMGIRYTNTPMDAVKDADIIIVATPVMAV-RDTFEDIQNHLKPGAIVTDTCSTKRQVMAWAKELL-------PTTVSFVGGHPMAGKTASLEECTYCLMAPEEAIETIGRLVTIFGANPYFMDAAEHDSYTAAISHMPFLAAAGLVNLV-----GTSSGWREMSRLASSGFQDTTRLAGGVAMHLDICRTNSDSIIGWIDR-----YQKQLSELRELIEQA.. 267
556 4.000e-47UniRef50_A0A1F6CLQ8 Uncharacterized protein (Fragment) n=1 Tax=Handelsmanbacteria sp. (strain RIFCSPLOWO2_12_FULL_64_10) TaxID=1817868 RepID=A0A1F6CL  ali  14  3...........................................................................................IGGSLGLACKRV-KACREVVGVSRPQTVEEAAVDRGVDYA-DLPDGIAGADAVFLCTPISRI-LSLIEEVIPCAGAGTVVSDVGSTKAEVVAKA-------GVLGRAGVHFIGGHPMAGSEKSGVVLTPAPDVSEPVQERFIAFVRRIGAQPVVMPPEVHDRVAAAISHLPQMIATALVSMVGQMDEGDGRFLRLA----AGGFRDLTRIASSPYVWRDICATNGPVIREMIDR...................... 240
557 4.000e-47UniRef50_X0X3S4 Uncharacterized protein (Fragment) n=1 Tax=marine sediment metagenome TaxID=412755 RepID=X0X3S4_9ZZZZ  ali  11  1...........................................................MGHGIAQVFAQRGYDVTLYDIDDNALRKALSLIEFSLDSLVEH-----------GLTTKEAKQQALSRIKVTTHLTEAVEQADFVTEATPILELKKQVFRSIEELCAAHAIIANTSGLSVTEMGSLCARQENL-------VITHWFNPPQI--IPVVELVKGLRTSQATFDCTFSLIEKLGKKPVKIMKEIPGFVANRIQFAMFREALALLEAGVASAEDIDTAIGPFETADLGGLDVWYIIA............................................. 236
558 5.000e-47UniRef50_A0A2H5Y6T9 3-hydroxyadipyl-CoA dehydrogenase n=26 Tax=Bacteria TaxID=2 RepID=A0A2H5Y6T9_9BACT  ali  11  8.......................................................GAGTMGRGIAYVAITHGAQATLYDVASGALENAAAQIEAWLQEATAKGR-LDEAEARRARERLQLSAAL-----------EDLAGAEVVIEAAPEDALKQEIFRQLDTLCPPGTILANTSSLSITALGAVTRRPE-------RVAGMHFFNPA--PVMRLVEIVRGLGTSEETLRALSDLARRWGKTPVVV-KDTPGFIVNRVARPFYLEALRLVGEGVADPHTVDRLMGPFELMDLIGLDVNLAVSKSIYAFFEEPRFRPHPLQRQMVQAGRLGRK............... 272
559 5.000e-47UniRef50_G7WGQ0 3-hydroxyacyl-CoA dehydrogenase n=2 Tax=Peptococcaceae TaxID=186807 RepID=G7WGQ0_DESOD  ali  15  12.......................................................GAGLMGHGIVQLAAQAGCEVVMVDLSAEMLYRGFEKINKLMYKAVKQGKILPEKCEEVLK-----------RIKISTDMND-LKDCDAVIEAIPIMELKKEVFAKLDKIVKPGAILTNTSQLSITEIASATGRSDLV-------IGMHFFYPAQV--MKLIEIPVGEHTSEKCINAIVDLSMRMGKETCVC-KDTPGFIVNRLLAGLMVEASRIYEIDKALKYALGHPMGPFELFDFSGIDTMVRVAD............................................ 247
560 5.000e-47UniRef50_A0A1F9DMJ4 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Deltaproteobacteria bacterium RBG_16_47_11 TaxID=1797838 RepID=A0A1F9DMJ4_9DELT  ali  13  1..............................................MTINKVLVVGMGLMGSGIAQVCAQSGFDTYVYDINSEACQKGLKTIEKTLGKRVEK-----------GKLSIEEKQAMMGRLKKIDRLEEA-RDADLAIEAVFEQEIKKEVFAQLGKVMPPHTILANTSALPATPFAAASGRPD-------KXXXIHFHQPPQV--MRLIELVRALQTSEETAQSAKEFCKRIDKDVCELKVDCPGFLTNRTMVALLNEVYYCLYEGVATKEDIDWPMGPLELSDFIGLDTMLHITEDLNKRRGGDKYVPCPLLVNMVAAGYFGKK............... 275
561 5.000e-47UniRef50_A9AWF2 Prephenate dehydrogenase n=4 Tax=Chloroflexi TaxID=200795 RepID=A9AWF2_HERA2  ali  15  36...........................................................................................................VIGYDGSSQQLRIARGRLAIDAEAKTAAEAVKEADIVVLATPVQTL-PALMREIAPHLRYKALVTDVCSTKASVLQWARELL-------PTTVSFVGGHPMAGREKNGAEAALCPNATAEATDLATAFVETIGAKPYYIDPEEHDIYVAGISHLPFLLATAQTEVVTRSP-----SWREMQMVAASGFRDITRLASGDPMHRDICSTNRTALIRVLVEMRTALEDDQIDELQRMFEHAK. 282
562 5.000e-47UniRef50_A0A2E5C1N6 Prephenate dehydrogenase n=10 Tax=Deltaproteobacteria bacterium TaxID=2026735 RepID=A0A2E5C1N6_9DELT  ali  11  9................................................................................FEAIAIVGLGLIGGSVAKDVRRL-GLARKILGYDNNEEYHKEIKSEKLADYLSNDKKLAQAELVLLAVPVKSFK-DILPLILPNISSTAILTDTGSVKSPLLKMMCSH-------DYENIRFLGGHPIAGSENFGCIITPEEKTDKESILVVRRFWESMGAKVSEMDPESHDQMFASVSHLPHILAYACIQAI--SNTDSHEALGHSG----AGLKDFSRIASSPEMWADIFLENQEKLLKVLSSLEEKIKNNDKKKLVELL..... 278
563 5.000e-47UniRef50_A0A2E3QQE3 Cyclohexadienyl dehydrogenase n=6 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A2E3QQE3_9RICK  ali  13  7..................................................................................KITIVGTGLIGSSIGLALKK-KKISKFVVGIDKSKRNLTYAIKSIDEARLKIDSRIADSDIIFLCIPVSQIN-QTIEKLSVYIKKECIITDVGSVKKNIIKLASNLF-----------YLVPGHPVAGTEFSGSKYAQHDLFEGKWLNIVSKIWKQIGMKISVMSIEDHDKIMSVTSHLPHFIAFTIV--GTAFKMDLKKKKELI-NFSAGGFRDFTRIGSSDRMWTDIFLTNKKFILKTLDNFLKLIKKDESEKIFNLLKKTKQ 281
564 5.000e-47UniRef50_A0A2E4B7X9 3-hydroxybutyryl-CoA dehydrogenase n=72 Tax=cellular organisms TaxID=131567 RepID=A0A2E4B7X9_9EURY  ali  13  1..............................................MEISTVAVIGAGTMGAGIAQVCAQAGWRTHLHDAHPDGLAAGMERIDAFWDK-----------GIARGKTTEEQKAAWSAHLHAVSDLGEAVATADLIIEAVPIMDLKQSIFTQVEALARPDAVLTNTSSLSIGTIASVLEHPERL-------IGMHFFNP--VPIMSLLEVVKHEGTSESTVSLALDAGAAMGKTAILVN-DVPGFATSRLGVVLGNEAIRMLADGVASAKDIDHPMGPLALTDLVGLDVRRDILLNLQASFNDDAYAPHPLLEALVAEGRLGKK............... 275
565 5.000e-47UniRef50_A0A1G3Q716 Uncharacterized protein n=1 Tax=Spirochaetes bacterium GWF1_41_5 TaxID=1802188 RepID=A0A1G3Q716_9SPIR  ali  8  18....................................................................................................................KTFSAELRKLGYKTKLSPEACAQQSDITVISVPIRA-TVQVIRKLGPLLGKNQALMDFTSLKEMPVKEMLACTRA---------EVIGCHPVFGPSVSNQVIVLTPGRGTAWFSRVKKIFLKTGAVIKVAKPAEHDRIMAVVQGLMHFTSITLINTLKTLNFSHEEIDSFSSPVYRIRMDFACRILNQNPLYADIEMLNLSAYLAENKKLFSAVKHRDREAFIRAFKRASD 255
566 5.000e-47UniRef50_A0A1V6AY63 Putative 3-hydroxybutyryl-CoA dehydrogenase n=89 Tax=root TaxID=1 RepID=A0A1V6AY63_9DELT  ali  13  13.......................................................GAGNMGHQIALQCALSGFKTVSTDVIPAVLEKAEKFVDTYLA-------------GRVQKGKMTEDKAARARISFTGDLKEAAKDADVVIEAVLERDLKRKVFAELDKYAPPDAILASNSSIVSSRIADATKRPS-------QVCNLHFFNPALV--MKLVEVVQGPHVSDETAKCMMDFCLKIDKVPIHIRKEVDGFVLNRIFSVIHKEALWMLEMGVASFEDIDHPMGPFRLLDLTGIDLAYDI.............................................. 248
567 6.000e-47UniRef50_M7NM87 Putative 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Cesiribacter andamanensis AMV16 TaxID=1279009 RepID=M7NM87_9BACT  ali  13  1................................................MKNITVIGSGTMGNGIAHVFAQKGYRVSLVDIRQDALDRALATIGKNMDRQISK-----------GLLDENAKRESLANISTYTDLKMGVQKADLVIEAATEQEIKLDIFRKLDELCPADTILS------SNTSSISITRIAAVTKRPQQVIGMHFMNP--VPVMKLVEVIRGYATSDSVTETIMTLSRQLDKVPVEVN-DYPGFVANRILMPMINEAIGVEEIDTVMKLGMAHPMGPLQLADFIGLDVCLSILKVLQEGFGNPKYAPCPLLVNMV....................... 265
568 6.000e-47UniRef50_UPI000DE814EB prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Roseimicrobium gellanilyticum TaxID=748857 RepID=UPI00  ali  15  16..........................................................................VNSRFPERVAILAPGLLGGSLLRALRERCEGIHLRV--WARREEAAQQVGKAGIAATTDLNEAVSGADFIVLCMPVEHMA-AIARQLVKAVSPGCVVTDVGSVKTSVVFALEQIFAASP------LHFLGSHPMAGSEKAGFEVTPTLLTDASALQVTRAVWEKVGCHLREISPEDHDRIVARVSHMPHLAAAVVTLAALHDHKDAASCIG-------NGFRDTTRVAAGDPLWRGIVAENRAEVLAALTEAR-----DRFNELLAMLEKMDD 284
569 6.000e-47UniRef50_A0A1J4WUK7 Uncharacterized protein n=3 Tax=unclassified Bacteria TaxID=2323 RepID=A0A1J4WUK7_9BACT  ali  14  6.....................................................................................................KKPLIGIIGGAGKMGEWFRAFFNSLGIKVILSNIELAQKADIVMVAVPIRK-AVEVIKEIRSAVKKDALLCDITSLKTEPVQAMAKAAS----------GVLGTHPLFGPDMKGQKIIFCPVKGSHWVKFLENIFTKNGAQIIMMSPQEHDWQMAIAQALTHFVNINLAQTFFSQKFNPNSS--FLTPVFRLQALIIGRILSGAQLCCDIEMENPYFFEQQIRSSAKDIANKNRKSFMEKIEKVS. 256
570 6.000e-47UniRef50_A0A1C8ZSU2 3-hydroxybutyryl-CoA dehydrogenase n=30 Tax=Sulfolobales TaxID=2281 RepID=A0A1C8ZSU2_9CREN  ali  21  9.......................................................GAGTMGHGIAEVSALAGFEVYVIDVSWDFLNRAKQRINESLIKFYEK--GILKEKPENVMSRINFSVS-----------YDVLKDADFVIEAVPELDLKRKVFENLDKVTPQNTILTNTSSIPISTIAEVTKRRE-------KVIGMHFFNPP--PIMKLVEIVPSKYTSEEVINVTIELANKMGKIPVRLRVEVPGFVSNRI-FLRLLGEATIQEVDSSARNGLKLPMGIFELADYVGLDVV................................................. 239
571 6.000e-47UniRef50_A0A1X3DHG2 Oxidoreductase n=4 Tax=Neisseria TaxID=482 RepID=A0A1X3DHG2_9NEIS  ali  13  27.....................................................................................................KHKGLVGQVAGVDLNAGNLERALERKVAFGTVCAEALAGADLVVIATPVATL-PDVCRSLCPLLDSRTVITDVGSTKQSAIDAFRRYLPEHLPR------CVAAHPIAGSDRSGAKLVVCPHGKEDSLLTVELLWQAVGARICRMGADEHDAVFAAVSHLPHLLAYAYVHQI-ATHADGSTYLDFA----ASGFRDFTRIASSPAIWADICMANKESLL-----TLLYGQQKQLAALAAMLENAD. 271
572 6.000e-47UniRef50_Q1Q6R0 Similar to cyclohexadienyl dehydrogenase/5-enolpyruvylshikmate 3-P synthase n=16 Tax=Planctomycetes TaxID=203682 RepID=Q1Q6R0_KUEST :  ali  12  11.......................................................................................GPGLIGGSIGLALRKRN-LAETVIGIGHQASSLESALKIGAIGHLNADNAVKNADIVILATSVGKII-EFAKQVIPFMKSNSVLTDVGSTKSYIVRQITK-------DMRDDISFVGAHPISGSEKRGIDHAITPNSNKKAVETISHLWSFLGAKVENISPERHDELLAYVSHLPHLAASCLVNAIAEDDLAYG----------ANGLKDTTRVASGDPEWRDIFGQNRENMIKSIDRFELTAFKNDLDMILKRLKKAK. 272
573 6.000e-47UniRef50_A0A2G6NGA3 Uncharacterized protein n=1 Tax=Deltaproteobacteria bacterium TaxID=2026735 RepID=A0A2G6NGA3_9DELT  ali  12  2.....................................................................................................KAKVVGIIGGNGSMGRWFKPFFETNGLKVVISDLNAAAVSDVVVISTPI-DVACDTAREVGPLLRKDQLLTDVCSLKETILDAMLAHTAAS---------VIGTHPMFGPTIDGQNMILCPERPGDWLPWLETLFTNAGARVTQMKPADHDKHMALAQGLTHMVSISLGKMLKEMQLTPADVWAVSTPIFRLNLELIGRFLAQNHLYASLIGQNRDQFREAMACGQAAILDGDKSTAIAFMAELK. 253
574 6.000e-47UniRef50_A0A075HRE1 3-hydroxyacyl-CoA dehydrogenase (PaaH, hbd, fadB, mmgB) n=124 Tax=cellular organisms TaxID=131567 RepID=A0A075HRE1_9EURY  ali  12  13.......................................................GAGQMGNGIAQVAAVAGFEVLLIDVKPEYLESGLSAIKSSLGKMVSKEK----------LSQADATQA-EARIRTGLNLEAAV-ESDLVIEAIPIPDLKFSTFSELDNLCAPHTILANTSSISINAIAAHTERPANV-------IGMHFMNP--VPLMKLVEIINGSATEASVTAAVIAAAERMGKTALCAN-DSPGFISNRLLCPMLNEAILSVQEGVAMKLGLNHPIGPLALADLIGLDTVLHIMQVLHAGFNDDKYEPAALLKQMVDAGQLGRK............... 277
575 7.000e-47UniRef50_A0A1V6AUQ9 Putative 3-hydroxybutyryl-CoA dehydrogenase n=16 Tax=root TaxID=1 RepID=A0A1V6AUQ9_9DELT  ali  16  13.......................................................GAGDMGHGIAAACLLGGYNVVLRDIEQKFVDKGVAGIITSLDKLKEK-------------GKIAPDVYAQALVRLTVDLQEAVQDADFIIEAVPEKDLKKSVFADLDKFAPKHAILANTSNMSITDIAAATNRPD-------KVIGYHFFNPAIL--MKLVEVIKGKNTSDESIQIGYEIAKKIKKVPVIVKRDSPGFIFNRVNEPTLVLLSKILEAGHPSPEEFDAAMAPFELVDYVGIDVAVH-----GLEYFSQVLSKDAILSYLKSGNLGKKTG.............. 278
576 7.000e-47UniRef50_A0A1H3MVC5 Prephenate dehydrogenase n=2 Tax=Tindallia TaxID=69894 RepID=A0A1H3MVC5_9CLOT  ali  13  1............................................................................MHDFNKIALI-GVGLMGGSFA-LALKEKGISCQITGFDTQKKALENAIQLSAIDFTSISDAVIEADLVVLGTPVGHY-DEIIREMLPALKKGAIVTDLGSVKEAAVKSAQNLPS--------HIQFIGGHPLAGSEKGGIEAALTPHTESRAVDKMKSLVSRIGGFPIIMTPEEHDSIVAKTSHLPHLMASVLTCMMENEKD--ESLKNFAG----SGFRDTTRIASGNPMWEEIFYYNEKELLKSLKRFQHAMISSNRDEIRRLLEIGK. 276
577 7.000e-47UniRef50_A0A218QSV2 Prephenate dehydrogenase n=3 Tax=Nostocales TaxID=1161 RepID=A0A218QSV2_9CYAN  ali  10  39...............................................................IAPQLAQAGIP---EFVWASIINSHAITTQSS-KVNNVKPMQITIIGGLGRMGRFFTQQLLAAGHNVSNDDWELLNQAELVLISVPIER-TVDVIKRAAKYLAPTTAICDITSIKTQPVAAMLAHHPGP---------VMGLHPMFGPNIKKQKVVVCPGRENHFFQWFLDFIKSQGGELIVCTPEEHDQMMVIIQATQHFSRFSLGVFLAQEKVDIERSLSMSSPSYRQEIDIVKRLFAQNPLCVDIMLATEEFLAETYSRLATLVEKRDRAGLIQEFETAQ. 324
578 7.000e-47UniRef50_UPI0004081982 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Thermithiobacillus tepidarius TaxID=929 RepID=UPI00040  ali  13  12.................................................................................ERIAVLGVGLIGGSLA-LALRRAGYSGRIAGYSRRTAESERALALGVEAAATPAEAVAGADLVVLGVPPGAM-PALMAQIAPTCAGQAVVTDVGSVKAAVVAAGEAQFGGR---------FIGAHPIAGKERHGVVITPTATSDPRALDLVRALWAAAGCEVLEMPPAVHDEALAVTSHLPHLLAFALMEQFAAHPRSKE-----LSRLTGGGFRDFSRIASSDPLWADIALQNREALLQAVQ-----IYQQTLERFAEQLRQGDQ 272
579 8.000e-47UniRef50_A0A1M4E2B5 3-hydroxybutyryl-CoA dehydrogenase 3-hydroxyacyl-CoA dehydrogenase n=21 Tax=Streptosporangiales TaxID=85012 RepID=A0A1M4E2B5_9ACT  ali  14  12.........................................................GTMGAGIAEVFARAGLRVIGVEADAEALARGRGHLERSTARA-------------VDKGRLTAERAEILGRVTLTTAREDLRDADLVVEAIPILDHKVALFRELDGICKPQTVLTNTSSLSVTALAAATGRPG-------RVVGMHFFNPA--PVMRLVEVVRTVVSEPEVVHQVGELAGRLGKTVVSVG-DRAGFVVNRLLLPYLNHAVVLMEQGVAGRDGIDLPMGPFTLLDLIGLDTAYEVMGVLFEETRDRRHAPAPLLRELVTAGLLGRK............... 274
580 8.000e-47UniRef50_F8AD81 Prephenate dehydrogenase n=5 Tax=Bacteria TaxID=2 RepID=F8AD81_THEID  ali  10  8........................................................................................................RLGIIGGAGRMGRWFKRQFEAEGYEVLLSNRELAKACQVIFVSVP-MSVFKDVVKDIGPFLNEDQGLIDFCSLKKEQNEIMLANTKA---------EVVAAHPLFGPGLEGQKIALWPSRGQTWFNWFKNFLEQKGAKTVVVSPEEHDRTMAVVQIINHLMLLALGKLMDTSGLDLKLIKDLATPSFERQLEIVARFADQDPLYALIQFDNPEKYLSILEDLVQIAARKDFEKFVSLFKDVQK 257
581 8.000e-47UniRef50_A0A2G3C1R5 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Capsicum chinense TaxID=80379 RepID=A0A2G3C1R5_CAPCH  ali  11  110..................GNNSTTYKQNSSELRLLGDQLIILGMADITRIGVV--GAGQMGAGIAQLAAVNGVDVWLYDTVSEALINAQKSISNNIQRLLTKGKISQATSVDAVK-----------RLHCSSSLED-LHSVDLVVEAILESEVKKSLFADLDKIVKSSAILANTSSISITRLASATSRPS-------QVIGMHFMNPP--PIMKLVEIIRGADTSEDTYCATKCLAERFGKTVI-CSQDYSGFIVNRILMPMINEAFHTLYTGVATKEDIDHPMGPLELADFIGLDVCLSIMKVLQAGLGDDKYAPCPLLVQYVDAGRLGKKR.............. 410
582 9.000e-47UniRef50_R0U855 Prephenate dehydrogenase family protein n=2 Tax=Neisseria meningitidis TaxID=487 RepID=R0U855_NEIME  ali  12  24.....................................................................................................KRQGLVRTVTGIDTDRDNLERALERGVIDRASDADSIGGADLVLIATPVATV-PAILTALRPVLPEHTWISDVGSTKSSVIEAFRRCLPDRLHR------CIAAHPIAGSDRSGRKLIITPHGGEDGIALIENLWHAVGAEIYTMDAQRHDAVFAAVSHMPHLTAFAYVHQILDHPDGQEYLK-----FAATGFRDFTRIASGPAVWADICLANKDSLLKQLDVLANILTTDDREALYRYFEEAK. 280
583 9.000e-47UniRef50_A0A2N5FG26 3-hydroxybutyryl-CoA dehydrogenase n=7 Tax=Terrabacteria group TaxID=1783272 RepID=A0A2N5FG26_9BACI  ali  12  10.......................................................GSGLMGSGIAQTFAAAGKTVFLYDVSEKALEKAQYGIDKSLSRFVKAGHL-----------SEEAKSKAASNIHTYTDLSEAVQSAELVVEAIPENELKKKMFQELDELTGKEVILTNTSELSVTAIAAATSRPD-------QVIGMHWFNPA--PVMKLIEIVKGIDTSDQTIEAIRLLSEEIGKETVLV-KDAQGFVTTRALSAHMLECIRIYEEGIASAKDIDKPMGPLELADLVGLDTMLFV--SNGMYGDRFL--PPQLLRKLVEAGHYGRK............... 274
584 9.000e-47UniRef50_A0A1W9GCT8 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Nitrospira sp. SG-bin1 TaxID=1827376 RepID=A0A1W9GCT8_9BACT  ali  12  13.......................................................GAGQMGRGISQVCATAGFEVLLVDVSEQSVTEAISKVRDGLERAVE-------------RGSLTDRQAVLALIHPLVQL-DHLRDAQLVIEAIPEDPLKRALFAELNRICVSQAVLANTSSISITKLGAASGRPD-------RVVGLHFMNP--VPVMRLVEIVRGLETSERTVRLVLDLATRLGKTPV-VAKDVPGFIVNRVLIPMINEAIFALEEGVASVQDIDHPVGPLALADRIGLDTMLAICEVLYQDLGDPKFRPCSMLRQYVQAGWLGRK............... 277
585 9.000e-47UniRef50_A0A2V9PF71 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Acidobacteria bacterium TaxID=1978231 RepID=A0A2V9PF71_9BACT  ali  14  10.......................................................GAGTMGNGIAHVFARAGYEVVLCDIEQKFLDRALTTIGKNLDR-------------EVAKNKISAQKAEAVGRIFPAVDRSRLSACDFIVEAASEREVKSELFRDLDRICRPELVLANTSSISITKLAATTSRAD-------RVIGMHFFNP--VPIMKLVEIVRGLATSDQTSETVKELALKLEKTPVEVN-DAPGFVSNRVLMPLLNEAMFAVMEGVATPEAVDHPMGPLTLADFIGLDVCLDIMRVLHEGLGDPKYRPCPLLKMVDAGWLGKKSGRV............ 278
586 9.000e-47UniRef50_G2RKP1 Tryptophan synthase, beta subunit n=27 Tax=Bacillaceae TaxID=186817 RepID=G2RKP1_BACMW  ali  14  1...............................................................................MKTRVLLIGVGLIGGSLALAMKQHRHVTVVGADINTNEIQLAKQLGIIDYVAEDIKTEAAQADYIVLATPV-EYTTAWIHDLSTWLKETVIVTDVGSTKGEIMKAAQ-------VLNKKRISFIGGHPMAGSHTSGAVYILTPFENEEKIDALMHLLEPTGAQFVPLDAATHDQITGVVSHLPHVIATSLVRQVK----GYSAQNHLVTEMAAGGFRDITRIASSNPMWRDILKQNRSMLLKEMEQVKLLVEKGDGHELFDYFSDAKE 278
587 1.000e-46UniRef50_A0A1V5REX8 Prephenate dehydrogenase n=2 Tax=unclassified Candidatus Omnitrophica TaxID=1047005 RepID=A0A1V5REX8_9BACT  ali  11  3................................................................................FKKIVIVGLGLMGGSLAAARKAFPKTLISGVTRNRRALARALRERWIDEGTGNVAFGASEADLIVLCTPVDVYLP-ILKEIDRVCGPGALVMDVGSVKGSVHALV-------NAKKWRRISFVGAHPMVGSHKRGIEVILTKKTCPGSFRKALRFWEKLVKKTVVLDPLTHDALVSEISHLPHAMAVCLVHAVSAKAL----------PLAAGGFRDTTRIAASDSIWLPIFEANRKKLERELEWFRRILRTSDTNRLRRYLDQAQK 273
588 1.000e-46UniRef50_A0A1F2PDT5 Putative 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Acetobacterium TaxID=33951 RepID=A0A1F2PDT5_9FIRM  ali  16  10.......................................................GAGQMGAGIAQAVATGGYRVILYDIKEEYCENAKEKIYASLKKRAEAGKITTDLVENTIEKINTTEDLKQLGI------------CDMVIEAVPVLELKQSIFKELGTICRPDAILCTNTST-ISVSQVMSE-----CTMKERCAGMHFFFPA--PVMKLVEVIRSNDTTDATVSVIKQVASYIGKTAIECKFDTPGFIVNRCLFAFLQEAATIEDIDTAMKQGLNHPMGPFEMMDMSGLDIYPHACES........................................... 247
589 1.000e-46UniRef50_A0A1F4TK79 Uncharacterized protein n=7 Tax=Candidatus Saganbacteria TaxID=1703751 RepID=A0A1F4TK79_9BACT  ali  16  26........................................................................................................GLTCQVIGISRREETIQAAIDRGAEGTTDLKLGVKDADLVFICTPISLIIP-TLKTIVPALKQGAIVTDVASTKGLIVAQAEKL-------TPKGCFFVGGHPMAGKEKKGATWVLTPTTDKNALETVAEYVALLGGKVMKMEPKLHDLVVAGISHMPLAVAAALVNTIAEAKEGQAEMKK----TAASGFRDTTRVASGDPLGVDMFTTNKAAVLKSLSNLEKVIKDGNAERIKAELEKAK. 278
590 1.000e-46UniRef50_A0A2G2JW41 Prephenate dehydrogenase n=4 Tax=Planctomycetaceae TaxID=126 RepID=A0A2G2JW41_9PLAN  ali  11  21..................................................................................................LALRNGKLASRVIGIGRRESTLQQAADCGAEFTLDLAAGVAEAEIIVVCSPVQLIAEHVLA-VSQNCRADALITDAGSTKQRIVAQLASGTPVP--------QFIGSHPLAGSDKSGAEVTPTEKSNEQQLAALTQFWEAIGCTVKQMSPAEHDKALALTSHLPHVIASLLAAS---------TPEELL-PLTATGWADTTRIAKGDQLWQQILDSNREPMLQALDEFRQALASGDDAQFISILDQGK. 272
591 1.000e-46UniRef50_D3RXI4 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein n=2 Tax=Ferroglobus placidus TaxID=54261 RepID=D3RXI4_FERPA  ali  16  10.......................................................GAGAMGHAIAELAAVSGFNVKIRDIKEEILKNAMERIKQSLEK-------------DFKKGRLKEDQAVLSRITATLDLKEAVEDADMIIEAIPIMDLKKQVFAECEEYCREDTIITNTSSLSITELSKALKKPE-------RFIGLHFFNPP--KVMRLVEIVWGEKTSEETVKITEEVARKMNRVIIHVRKDVPGFVVNRIFVTMANEAASVEEIDSAVKYRMGLPMGLFELHDLLG..................................................... 237
592 1.000e-46UniRef50_A0A1Q7CHZ1 Uncharacterized protein n=9 Tax=Bacteria TaxID=2 RepID=A0A1Q7CHZ1_9ACTN  ali  13  3...............................................ELKRVLVVGAGTMGSQIALQTALGGHDVTLVDTVEGQLQRARAQNRRLVDRSVEK-------------GRLTREQADQARIADSSDLATAAASADLVIEAVIENDAKKSVFEALGKHAKKTAILASNSST------IAISRLADVSGRPEMCCNMHFFHP--VTVMQLCEVVRGPKTSAETVDAAMEFVRSIGRTPVLLQKEIWGFIVNRILFAASEEAMRLLEGGYASAEDIDWPMGPFHLLDFSGLDIFYGAM------KDRQAQAPEVLRKLVEQGRLGKKTG.............. 278
593 1.000e-46UniRef50_A0A2A6D013 Uncharacterized protein n=1 Tax=Pristionchus pacificus TaxID=54126 RepID=A0A2A6D013_PRIPA  ali  14 1057...........................SSKVSTPLARALSTSSSSLAPIKNVTIIGAGLMGAGIAQVSANAKLNVVLVDMNDKVLEKSRASIDASLARAQKSFV------------ADTMKH-----LKVSTNTSEAVSQADLVIEAIVENDVKRKLFAEVEKAAKSSAILTNTSSLRLSDI-------GLKLKNKSQFGGLHFFNP--VPMMKLLEVVRHDETSEETYKSLMEYGKSIGKATVTC-KDTPGFIVNRLLIPYMYEALRMADIDTAMKLGAGYPMGPFELCDYVGLDTTLFIGQGWAKFPNEPLFKPSPTLEKLVKEGKLGKK............... 1345
594 1.000e-46UniRef50_A0A2H0QSW3 Cyclohexadienyl dehydrogenase n=1 Tax=Alphaproteobacteria bacterium CG11_big_fil_rev_8_21_14_0_20_39_49 TaxID=1973900 RepID=A0A2H  ali  13  11.......................................................................................GLGLIGSSIAQAAKKYHA-AKTITAFDLNEESINKALELGINGYNNLSDSVKDSQMVIICTPISTY-DAIINEIAPKLDKDTIITDVGSVKKSVIDIISPKLKYPE-------NFVPAHPIAGSEKSGLEFIITPKSSSSSITKVDRFWQTLGSNIEIIPPEEHDEIYAKSSHIPHLAAFCYARIMKNQNISLAKLVENEGDEFAAFVRLA---FSNPQMWTDIFLYNKEPIIKNLDPSNIIKNNDEIKVLYERIENA.. 277
595 1.000e-46UniRef50_A0A0N0Z403 Putative 3-hydroxybutyryl-CoA dehydrogenase n=5 Tax=Terrabacteria group TaxID=1783272 RepID=A0A0N0Z403_9BACI  ali  15  9.......................................................GAGVMGSGIAQTAAMAGKTVYLYDVSEAALQNGLASAEKSLRRFVKTGGL-----------SESEAAAALGRIRSTVDLAEAVRRADVVIEAVPENALKKDVFQQLDQLAKPDAILTNTSELSVTALAAATKRPENV-------IGMHWFNPA--PVMKLIEIVKGETTSDDTVDAIRRLSVELGKETVVV-KDRQGFVTTRAIAAHMIECIRMYEEGVASVEDIDKAVRL............................................................. 220
596 1.000e-46UniRef50_B3DXN1 Prephenate dehydrogenase n=3 Tax=Methylacidiphilum TaxID=511745 RepID=B3DXN1_METI4  ali  13  15.......................................................................................GPGLMGGSIAKACMERALSKRLVIGAREDELDLLKKSGLNAAFYNDFGLSVKGSDLVVLCVPLEALKP-ILLEIKDFIGPETIVTDVTSVKREVISLFSEILT-------EKVQWIGGHPMAGSEKSGFELTPGLHVGSQALDIVITFWEKLGSKTITLSAEEHDALVSEISHLPHLLSAVLMTAVSL------RSLTLAGP----GFRDITRVASGPHLWKSILLANRHSVCEALEEALKILQIGDEKALLELLNKA.. 275
597 1.000e-46UniRef50_C3MN04 3-hydroxyacyl-CoA dehydrogenase NAD-binding n=25 Tax=Archaea TaxID=2157 RepID=C3MN04_SULIL  ali  14  11.......................................................GAGTMGHGIVEVAAISGYQVYLSDVSQDILNNALEKIRWSLQKLKES-----------GKLKESIDTIIS-RIKPTTNLND-FADADYIIEAVVENEVKRKIFSELDGIVKPNAIFTNTSTIPISTLAEATKRQD-------KFIGLHFMNPPVL--MPLVEIIMGNKTSQQTLEITIEFAKSIGKDYVIVKKDVPGFLINRINGRTFAEAILMEDIDAMTRFRLGMPMGFLELLDFTGIDV.................................................. 239
598 1.000e-46UniRef50_A0A097AR09 Prephenate dehydrogenase TyrA n=29 Tax=Thermoanaerobacterales TaxID=68295 RepID=A0A097AR09_THEKI  ali  15  4..................................................................................NAVIVGLGLIGGSLAKALSKYTDIKVMAVDINENSLHKALEEGVISYGVTDLDFQV-DADLVFICTPVGKVVEK-AKNILPYLKKGCIVTDVGSTKKVIMEEVQKFL-------PDEIFFIGGHPMAGTEKAGYNYLLTPNVKEDVLDLFIEVIIKIGAKPVIMDYNKHDAIVGIISHVPHILSATLTNF---AHDKCSEAFKYA----AGGFKDTTRIASQTEIWKDIICTNKEVILELLKNYREVLENDDIDTIQKFLEDARK 274
599 1.000e-46UniRef50_B5JNY1 Prephenate dehydrogenase n=1 Tax=Verrucomicrobiae bacterium DG1235 TaxID=382464 RepID=B5JNY1_9BACT  ali  9  1...............................................................................MFQTITIVAPGLLGASLA-IAASEKGIAQHVSLYARRQEAVDQLLQKCSRASADLAEACRDAELIVLCAPVDRII-TLAQEIAKFATGNPIVTDVGSVKGDIVRHCETALTGKAR-------FIGSHPMAGSEKTGMEVTPSPNSDSDALAKTIAFWKAVGSTIIEETPDKHDEIVAQVSHLPHVLASSLSAFLAQRCPNAEE-------YCGNGLRDTTRVASSPDLWREIIGQNRHEVLRAIR....................... 245
600 1.000e-46UniRef50_A0A2D8M1F9 Uncharacterized protein n=1 Tax=Micavibrio sp. TaxID=2024841 RepID=A0A2D8M1F9_9PROT  ali  14  13.............................................................................................SSLARDLKKSQGHEIYVHDN--NADFLEQAKELLADHYGDIKRLASNCDIVFICVPVRAI-LKVIEEILPHMKEGSIVTDVGSVKSS--------LYVNPKAMPKDVVYIPGHPMAGREFKGRKWIITPDKSETQVNKLKDLLDSLGANVLSLSANVHDEMLGFVSHLPHVMAFSAMQAANELDQMLDE---DVFTFAGGSFMDLTRIAGGDPMWRDIFLTNKDSILAAMDELKTLIENESVEEIHQFVNTAHK 275
601 1.000e-46UniRef50_A0A2X1PNR0 Fused chorismate mutase T/prephenate dehydrogenase n=3 Tax=Haemophilus influenzae TaxID=727 RepID=A0A2X1PNR0_HAEIF  ali  14  1...................................................................................MRESYANENQFGFKTINSDIHKIVIVGGYGKLGGLFARYLRASGYPISILDREDLANADVVIVSVPIN-LTLETIERLKPYLTENMLLADLTSVKREPLAKMLEVHSGA---------VLGLHPMFGADMAKQVVVRCDGRFPERYEWLLEQIQIWGAKIYQTNATEHDHNMTYIQALRHFSTFANGLHLSKQPINLANLLALSSPIYRLELAMIGRLFAQDELYADIIM.................................. 231
602 1.000e-46UniRef50_A0A150MVH1 Prephenate dehydrogenase n=18 Tax=Bacillales TaxID=1385 RepID=A0A150MVH1_9BACI  ali  13  4..................................................................................NVLIVGLGLIGGSMALAIKKAHEAVIIGYDVDERQLGLARSLKVIDEAAGSLTEAYERANLIVLAAPVMQ-TEALLSSLLERLKPGVIVTDVGSTKRRIVERARRLLEC-------GVAFIGGHPMAGSHKSGVILTPTEEVAVQRVEILKRWLSGTKAQFVILTPEEHDRITGVISHFPHLIAASLVHQARE----YECENALVSRLAAGGFRDITRIASSNPMWRDILIHNKQEMLTLFDRW--MAEMEKLRSFVEE...... 264
603 1.000e-46UniRef50_A0A1V5YLL3 3-hydroxybutyryl-CoA dehydrogenase n=3 Tax=unclassified Chloroflexi (miscellaneous) TaxID=189774 RepID=A0A1V5YLL3_9CHLR  ali  10  12.........................................................GLMGSGIVETCARCGYDVIVREVNQELLDRGLARIKGSMAKGVEKGKLTAGEM-----------DAAWARIRGTCALEE-LQASDLVIEAVTEMAEKKAIFSTLDRLCPAHTVIANTSSMCITEMAAATKRPD-------KVLGMHFFNP--VPIMPLLELVRTIQTSDDTLQVARDVGASLHKTIV-VAKDTPGFIVNLLLVPYLLGAVRALEIDTAMKLGLNHPMGPLTLLDFIGVDTAYYIANVMYDEFKEPQYAAPPLLKRMVLAGHLGRK............... 274
604 1.000e-46UniRef50_A0A238LBH9 Putative 3-hydroxybutyryl-CoA dehydrogenase n=8 Tax=cellular organisms TaxID=131567 RepID=A0A238LBH9_9RHOB  ali  13  10.......................................................GAGQMGNGIAHVFALAGYEVLMTDISADALEAAKALISKNLDRQVSR-----EVISQAQKDEAF------SRIGSTLTLTD-LGQTDLIIEAATEREVKQAIFEDLIPHLKPDTILTNTSSISITRLAARTDRPE-------KFMGFHFMNP--VPVMQLVELIRGIATDKETFDTCLAVVDSLGKT-ASSSEDFPAFIVNRILMPMINEAISVKSIDTSLKLGANHPMGPLELADFIGLDTCLAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRK............... 274
605 1.000e-46UniRef50_A8ZZN2 3-hydroxybutyryl-CoA dehydrogenase n=3 Tax=Bacteria TaxID=2 RepID=A8ZZN2_DESOH  ali  15  13.......................................................GSGAMGHGIAQVCIMAGYTVVMVDVKQEFLDNGMKKVKESMDFLVGKG-KLSAEDKDRMMGQLS----------TSLDNKAAVADVQVVIEAVPIMDLKKKVFADVSSAAPAEALLANTSTMSITEIATAVTKPE-------RFLGMHFFNP--VNRMKLVEVIFGEKTSAENVDLLCELSKKIGKIPVKVLKDSPGFIVNRIGAPNQALISAILDEGAIKPDEIDAPMGPFELADYVGIDVFYH............................................... 246
606 1.000e-46UniRef50_A0A2E6L1P4 Prephenate dehydrogenase n=4 Tax=Bacteria TaxID=2 RepID=A0A2E6L1P4_9BACT  ali  15  24........................................................................................................GAGQEVILWGRNPERVEITRKIGLEATTDLDGAVKEADLIILAVPVGVMGL-LFESIRGNLKPGAIVTDVGSVKALPHKVANEH----------GIPFIGSHPMAGSEQTGIEAARADLRPNEELRAVARFWENLGCVTSVMNSKDHDRAVARISHLPHAMAVATAGAALRFPGD--------EFLAAGGFRDTTRVAGGDPMWAEIMVENRAAVTAAL-----LDAQEEMREMLDHLAKSDK 256
607 1.000e-46UniRef50_A0A142YI51 Prephenate dehydrogenase n=2 Tax=Planctomyces sp. SH-PL62 TaxID=1636152 RepID=A0A142YI51_9PLAN  ali  13  24.....................................................................................................RDRGLVDEVVGVGRDMGSLEQARARGARATTDMADGVSRADVVVVCTPVGRVAEDV-RRAADAAPRGALITDAGSTKRAIVEAVDKLPRAAEM-------FVAAHPLAGSERSGRVCVLTPRTAPDRLRRAREFWSSLGTRIIEMGPAEHDEVVAYTSHLPHALAASLAATVPAD----------WLPLAAGAFRDGTRVAGADELWTAIFRDNRGPLMDRLSSLKYALMNDDEESIRRWWNDAR. 273
608 2.000e-46UniRef50_E0RVR1 3-hydroxybutyryl-CoA dehydrogenase Hbd n=367 Tax=root TaxID=1 RepID=E0RVR1_BUTPB  ali  13  7.......................................................GAGTMGSGIAQTFAQAQSKVYLCDIKTEFAEGGFAKIKKGLDK-------------QVAKGKKTQEEADAITAKIQTGLNDICADADLVVEAAEVMDIKKNLFKELQENINPDCIFANTSSLSITEIGSGLAKP---------IIGMHFFNPA--PVMKLVEVIQGANTPDDYVEKIKKISEDLGKTPVQVN-EAAGFVVNRILVPMINEGIFVYSIDTAMKLGCNHPMGPLELGDYIGLDIVLAIMDVLYSETGDSKYRACPLLRKMVRGKKLG................. 270
609 2.000e-46UniRef50_A0A285HG47 Prephenate dehydrogenase n=1 Tax=Orenia metallireducens TaxID=1413210 RepID=A0A285HG47_9FIRM  ali  14  4..................................................................................RVAIIGVGLIGSSLGLALGDIQEV-EEVIGIDKNQDYLQEALNIGIDKIASLKEGVRDVDLIILATPVG-IIKDLVVEVLPYIDNKTIITDVGSTKSTLVRKLEVLVGDHI--------YIGGHPMTGAETSGPVLTETEKTDQASLAELKNILEKIGSQVLVLSPENHDRTVAVTSHLPHLIAVNLMSVIEQFSQKDEQV----TSLIAGGFRDTTRIAAGDPMWRDIFLNNKEMVLETID-----IFEERLSSLKELI..... 259
610 2.000e-46UniRef50_A0A0T6A4S5 Prephenate dehydrogenase, prephenate dehydrogenase n=2 Tax=Candidatus Rokubacteria TaxID=1752708 RepID=A0A0T6A4S5_9BACT  ali  11  9.......................................................................................GLGLLGGSVAKAA-RERGLAREVVAVGRRLESLAAARSERVRVTTDLGDGLAGADFALLATPVAT-AEGLMPKVWQAAADGAXITDVGSTKGPIVRSAERL------AADRPLAFVGSHPMAGSERSGVIVTPTERTDPLALKRVSEFWEALGCRVGVMDPDEHDRAVAAVSHVPHLVAYALVEAVARLNPA-------FFGVAARGFKDTTRIAASDAVWREVFQSN................................ 237
611 2.000e-46UniRef50_T0J8J1 3-hydroxybutyryl-CoA dehydrogenase n=12 Tax=Bacteria TaxID=2 RepID=T0J8J1_9SPHN  ali  15  8.......................................................GAGIMGSGIAQTVAGKGMDVILSDISIENADKGKAGIAKGLARLVAKEKIAQSEV-----------DALLPRITTAGDYA-AMGDCDLIIEAATERDTKLKIFAAVGEVLGANAILANTSSIPITRMAAA-------SPDPTRFCGLHFFNP--VPVMGLVEVIPGLATSEDTTARMKAFGEALGKTVV-LAGDAPGFVVNRILCPLLNEAISVEDIDAGMRLGANHPMGPLTLADFVGLDTLYEIMKVFQATTGDPKYRPAPLLQKYVEAGWYGRK............... 272
612 2.000e-46UniRef50_A0A2H0LGK3 Prephenate dehydrogenase n=4 Tax=unclassified Candidatus Omnitrophica TaxID=1047005 RepID=A0A2H0LGK3_9BACT  ali  13  24.....................................................................................................KRRRLAREVIGLGRKRPTLLAARRRGVRGETDPKRALRGADLLVIATPVDTIAP--FAALSRWLKPGAFVMDVGSTKAAIVRVAQK-------EMPDGVAFIGAHPIAGSEKRGCVLTPTPRTPSAALSRARRFWRALGSDVITMSPQAHDRLLASTSHLPHALAYCLSRSVEI------KPFRRAPPS----LLDMTRIAKSDPLWDDILLANRKELLSAMARFERSVRSGRRDALRRFLIQAQ. 273
613 2.000e-46UniRef50_Q88GG9 3-hydroxybutyryl-CoA dehydrogenase n=115 Tax=Bacteria TaxID=2 RepID=Q88GG9_PSEPK  ali  12  10.......................................................GAGTMGNGIAQVCAIAGYQVLLVDVSDAALERGVATLSKNLERQVSKGTLDADKAAAAK-----------ARIRTSTDYTQ-LSAAQLVIEAATENQLKQRILQQVAANVAADCLITNTSSLSVTQLAASIEHPE-------RFIGVHFFNP--VPMMALVEIIRGLQTSDTTYAQALMVTEKVGKTPI-TAGNRPGFVVNRILVPMINEAISAEDIDTGMRLGCNQPIGPLALADLIGLDTLLAIMEAFHEGFNDSKYRPAPLLKEMVAAGWLGRK............... 274
614 2.000e-46UniRef50_C7RU17 Prephenate dehydrogenase n=111 Tax=root TaxID=1 RepID=C7RU17_ACCPU  ali  13  14..................................................................................KIVIFGVGLIGGSFA-LALKSAGEVGEVVGFGRRLGSLTQALDLGIRAGFNIGQEVGNADLVLIATPVGT-TPEIMARIAPCLGPQTVVTDAGSTKGDVVAAARAHFGERLG------QFVPAHPIAGAENSGVVLTPLPENAVASVARVRAAWECCGALVRELSPAEHDRVFAAVSHLPHLLSFALVHDLTR-RDNRDLLFDFA----ASGFRDFTRIAASPEMWRDICLAN................................ 249
615 2.000e-46UniRef50_A0A2E0Y0V3 Bifunctional chorismate mutase/prephenate dehydrogenase n=1 Tax=Phycisphaerae bacterium TaxID=2026778 RepID=A0A2E0Y0V3_9BACT  ali  13  69..........................QVADVKRQSGFP-IRDPEREGSMLADRRMLGSADG--IRPEVVESLFRVILWASRDRQASLRAAVPVKVEPRTIAIVGGLG--GMGTCLGRMFDEQGHEVLVETTLRPKEAAARADVTVISVDIRA-TREVIELVGPSCRENSLLCDVTSIKDDPVKAMVDA---------SHCTVIGTHPLFGPSLQGQRVVVTPGRDDRWTSWLESSLRAGGLEVIETTPDRHDRIMSVVQVLTHYSTEVIGRTMQNLGVSIEESLQFTSPIYHMELLMAARHFAQSPLYSAIEMTNPNAFTEAAEELRRLILDGDQEGFRRAFGEVSE 389
616 2.000e-46UniRef50_A0A2V9VDP6 Uncharacterized protein n=1 Tax=Acidobacteria bacterium TaxID=1978231 RepID=A0A2V9VDP6_9BACT  ali  14  409.........................................................GLMGSGIAQVAATAGFDVTVLEVEQKFLDKGFAGIEKSLAKLAEKGTLKET------------PEAVRARLKGTTK-REDLAGCDIVIEAIIENEEKKKVYAALDSVVKKEAIFANTSSISITELLTSTKRPE-------RFVGLHFFNP--VPLMKLVEVVRTIATANEVYESAYEFAKKLGKVPVRTS-DKTGFIVNRLLVPYLLDAISIEDIDNAMKLGCGYPMGPFTLLDFVGLDTTYYITHVMYDEFKERRFASPPLLKRMV....................... 662
617 2.000e-46UniRef50_A0A259U5N5 Putative 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Firmicutes TaxID=1239 RepID=A0A259U5N5_9FIRM  ali  14  14.........................................................GLMGSGIAQVAATVGYPVVLYDISTKIVEKGKKNIQALLDKAVAKGKKTRED-----------ADATLARIKATAD-KADLADVDIIFEAIIEKDIKIELYSSLDKICKPSCLFTNTSGLSITEIGAATGRSD-------KFVGMHFFNP--VPVMKLVEVIRGYDTSDETFTTALEMGKKLGKESIAVQ-EAPLFCVNRILVPMLNEAMFVLSEGIATAEDIDKPIGPLALADMVGLDTLLLVAQTLFNETGDSKYRPCPLLVKMVRAGHYGRK............... 276
618 2.000e-46UniRef50_K1Y892 Prephenate dehydrogenase n=1 Tax=groundwater metagenome TaxID=717931 RepID=K1Y892_9ZZZZ  ali  14  30.......................................................................................................KNIAKEVYGFIRKPETGEKIISLKLDAGNDPSKAFSDADMIVLAVPTGVVSEQ-LKLLLPFVKKHTIITDLCSVKQKVVTESEKILKGK-------ADFVGSHPMTGTEKFGCIVTPTKNTSLSASEKTIKMWQILGSNVYKMTPGEHDIGASLISHLPHVVSNVLMASIWSEKEKIPGLFNMS----AGSFRDMTRIVSSPELWADIFLNNKKEVLKKLDLFTQNLKHENVSDILNYLNNTNK 284
619 2.000e-46UniRef50_A0A0S7ZH51 Uncharacterized protein n=1 Tax=Spirochaetes bacterium DG_61 TaxID=1704237 RepID=A0A0S7ZH51_9SPIR  ali  13  3................................................................................DERVTIIGTGLIGGSLCSAFKKKNKWVRAVS----SRPTLDRAKKLHIIDESQIGEAVRESDFVFVCTPLLDILPDIFQQVD----KNTIVSDVGSTKMNICSRAGQLL-------PKGVYFIGGHPMAGSEKRGIEYVLTPGTPRSAIRKLSCLIGLLGAKVMVLEPEKHDRIAANVSHLPQLLAVLLTNHLASKDSD------LFRNLAAGGFRDMTRIASSSFIWRDIISTNQEQIREALGDFQLIDNLQNEEYLKSSFEAAQK 274
620 2.000e-46UniRef50_A0A1V5KEJ2 Prephenate dehydrogenase n=1 Tax=bacterium ADurb.Bin478 TaxID=1866932 RepID=A0A1V5KEJ2_9BACT  ali  15  3............................................................................EIEQFKRVVIVGVGLIGGSLAALKKKGFKGKICGVDSAEVLALAEPRRMLDESYTRDLLEAVIDADIVFLCTPILDILR-LIPEIGPAVKAGALITDVGSTKRTIVETA-------SIYLPVGVDFIGGHPMAGSETKGVEYVLTPVRSEQTRKALGELIELIGAKVLLLSPVLHDEIAAAVSHLPQMAAIAMMTLAAKRQSES----PYFLKMAAGGFRDMTRIASSPYIWEHIRQTNADMIAQYIDELSSLRDRLNSEALGKIFTAASE 281
621 2.000e-46UniRef50_A0A101DXJ2 Prephenate dehydrogenase n=2 Tax=Euryarchaeota TaxID=28890 RepID=A0A101DXJ2_9EURY  ali  14  39.......................................................................................................................VDVARQLGCEYVERLPSVVPTCDWVMLSVPIDAI-ERVASQVAPHMKEGSMLFDVCSLKQGPLDAMLKV-------APEGVEVVGTHPMFGPTIPGQTVIVSTSRSGSGFERLRQMLEEEGAHVQQMSAREHDMAMAVVQGLTHFAYITIGSTLRRLEFDVGASRTYMSPVYEVMVDFVGRILAQNPLYALIQ-TNPAAFVEEAKRLASLIDGGDVEGFVASMRAA.. 268
622 3.000e-46UniRef50_B0TFQ3 Prephenate dehydrogenase, putative n=5 Tax=Firmicutes TaxID=1239 RepID=B0TFQ3_HELMI  ali  17  20..............................................................................DVFRRVVIIGLGVIGGSLA-MALTQGQLVDEVIGVDRDEETRKLALAAAHRVEADAAEAVAEADLIVLATPVCTY-PAIIASIRHRLKPGTIVTDVGSTKQWVLEQM-------GRLLPPGVRFVGGHPMAGSEKQGIVYVLTPDTDAAALQALEDLIKAAGARVLRISAEEHDSMVALVSHLPHMMAVALVETLSEAKEYPKAPM-----LAAGGFRDTTRVAAGDPMWVDIACTNREPLLSALDRLEEQIDASKMEALRETLAHARE 303
623 3.000e-46UniRef50_A0A2R6BTG8 3-hydroxyacyl-CoA dehydrogenase n=6 Tax=Candidatus Marsarchaeota group 2 TaxID=2203771 RepID=A0A2R6BTG8_9ARCH  ali  15  14.......................................................GAGTMGHGIAETVALAGYTVRLEDAYPEALDRAMRAIRVSLDRFVSSGR--------IDRSKADEAYA---RISYHGSLEEAVEGVELVVEAVPEDELKRGLFAKLAKLTPKGVILSNTSNIRITRIAAGTGREGDI-------VGIHFFNPPVI--MKGVEVIRGEGTSDEVFEDAVSFVASLGKKPIRVLKDTPGFVVNRITAPEGLLFCLLLDRGVSHAEVDGLPMGPYELMDYVGVDVVAHSME----YYGDELSADY---KKCSSLSAMVRQGRL............ 274
624 3.000e-46UniRef50_F5SKZ9 3-hydroxyacyl-CoA dehydrogenase PhaC n=6 Tax=Bacteria TaxID=2 RepID=F5SKZ9_9BACL  ali  10  11.......................................................GAGTMGAGIAQVLASAGYPVHLWDIGEQPLARG---VDGILKRLNR----------QVEKGRLSQEEADGARVRTTSRLEE-LASADWVIEAVVERQVKRELFTRLEAVTGEEAVLTNTSSLSVTSIASALRRPERML-------GLHFFNPA--PAMPLVEVVKGMRTAPETVEGAVRFVRSLGKHPVQV-KDTPGFLVNRVARPFHLEAYRMVGDGVAEKEQLDRIMGPFELQDLIGIDI.................................................. 239
625 3.000e-46UniRef50_A0A2T6E4S7 3-phosphoshikimate 1-carboxyvinyltransferase n=2 Tax=Saccharospirillum TaxID=231683 RepID=A0A2T6E4S7_9GAMM  ali  11  5...............................................................................ASPRVLIVGLGMIGASFAKALRLSRAAYVLGMDAQPGVA--DRALELGIDDSVASAEDVPAFDVLMLAVPVLAM-ESVLTTLQPYLTDQTIISDVGSVKGQVVASARKALGNELPS-----GFVPGHPIAGAERSGVEAAKADLFDRHLLSVLTQLWQAVGAEVVTMSVSRHDEVLAATSHLPHLLAFSLVDTLARESEN-REIFRYA----AGGFRDFTRIAASDPMWHDVFLANKDATLGILRRF-----QGDLEHLAQAIEQGE. 268
626 3.000e-46UniRef50_A0A068NEN5 Histidinol-phosphate aminotransferase n=9 Tax=Bacillus cereus group TaxID=86661 RepID=A0A068NEN5_BACCE  ali  12  362............................................................................MRQMRKQVVLIGTGLIGGSLALAIKKEHDVTITGYDIFQEQVERAKELHVVDEIAVDLQHACEEAHLIVFASPVEE-TKKLLHKLASFLRKDVIVTDVGSTKGTIMNEAEALFS-------KEISFIGGHPMAGSHKTGVEYILTPHVPNEHVEELKDWLKGTGSHFFVLNTEEHDYVTGIVSHFPHLIAAGLVKQVEKHAGD----NPLIHQLAAGGFKDITRIASSSPMWSDIVKQNREHLMVLLKELYVTVSTGDAGEIQNYFADAKE 642
627 3.000e-46UniRef50_A0A1V5Z0C0 T-protein n=2 Tax=unclassified Candidatus Hydrogenedentes TaxID=1046981 RepID=A0A1V5Z0C0_9BACT  ali  16  25.....................................................................................................KRRKSGARITGVGRRAESLEKALQCGAEISLDPLSASAQADAVIIATPVQQVIP-LLDLLAPHLSPNALVMDVASVKQEICDHARRIFPVPRR-------FVGCHPMAGGEKFGPENTVCPDLSEEAQQAARAFWEFVGTRVVTLNAARHDALLARTSHLPHVAAAALARIVYDAGAD-------STLIGRGFLDVTRIAASRAEIWRDISLSNRGALLQSLDAFEAALTKGDAAAVEDFFEKAAE 277
628 3.000e-46UniRef50_UPI0008D94C91 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Pelistega sp. MC2 TaxID=1720297 RepID=UPI0008D94C91 :_  ali  12  22.................................................................................................ALALKRQGLVEKVLGAGKDDNSLGLAKALGIDEVVTIAEMATLADVIVIAAPVNAF-EGIANVLAPLLPANTIVSDVGSTKAKIIEIARKVFDN------KIHQFIPAHPIAGSHASGVIITPLPENSSESVALIQSLWESCGATVQLLKAKDHDDIYAAVSHFPHFLAACYMSFMES-----DPIRKQALNMGGTGFRDFTRIAASPEMWRDIFLSNQEAMLSQMRDF-----EKEFNYFKQLLENKD. 269
629 3.000e-46UniRef50_A0A0S2KDT9 3-phosphoshikimate 1-carboxyvinyltransferase n=3 Tax=Pseudohongiella TaxID=1524249 RepID=A0A0S2KDT9_9GAMM  ali  15  31..........................................................................................................CRRILACGRDEGPLQTALLDGVIYATTPDTLVPDADIILLATPTLTVAR-VLEQISDLLRADAIVTDAASVKGSVLADARRILGSASSR------FVAGHPIAGSEQSGRKVILTPVAENQAVQTVMQLWQCLGADVHAMSAGRHDRILAGTSHLPHLLAFALVNTLVDKVGEPDRPQQVFD-YAAGGFADFSRIASSDPMWRDIFLANREATVSVLDAMNSLTDMKRL............ 268
630 3.000e-46UniRef50_A2SR17 Prephenate dehydrogenase n=14 Tax=Euryarchaeota TaxID=28890 RepID=A2SR17_METLZ  ali  11  39.........................................................................................................................KVLCSGRKTPVSNADIASTCDIIIVSVPIHD-TVRVIDEIAPLLNEEQLLCDLTSIKTAPVDAMLKSKA----------QVIGLHPMFGPSVPGQTIAASPVRDEKTRHTLYQIFTNEGAKICQMEPKEHDKIMSIVQGLVHFTTLSVAETIKNTGIPLEAILPVMSPVYRIELGLVGRILGQDPLYADILQMNPETMSDSVTALKAIVASKDSEKFAAFFTENSD 264
631 3.000e-46UniRef50_A0A1F2SD09 3-hydroxybutyryl-CoA dehydrogenase n=4 Tax=Bacteria TaxID=2 RepID=A0A1F2SD09_9BACT  ali  13  12.........................................................GLMGSGIAQVTATAGFRTVVVEVNEELSRKGLHNIVQRLERLIQKGTVSDQE-----------KTAIQSRLRATTD-KSQLANCDLVIEAITENDEKLRLWRSLDGIVKREAILANTSSLSITEMMMATSRPE-------RFVGLHFFNP--VPVMELVEVIRTILTDPPVYETVLAFAQSLGKIPVR-TADRAGFIVNRILIPYLMDAIRISDIDRAMQLGCGHPLGPFVLLDFIGLDTACSIANILFEEFREPRFAPPGLLKRLV....................... 266
632 3.000e-46UniRef50_A0A2N2KQA3 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=3 Tax=unclassified Deltaproteobacteria (miscellaneous) TaxID=12  ali  9  34..............................................................................................................................GRKTRLKISDLAGSCNVIVVAVPI-AATAEVIRQVGPLMSADSLLMDLTSLKKEPVELMLSC---------SRAEIIGCHPLFGPDVRGQNVVLCPARGDKWLSWLKVILERKGLIVIEKAPEEHDEMMAIVQVLNHLNTISFGLALAAAGIDLTEINKLSTPIFQTKMEIVKKVFENPGLYTDIIAQNPAAMEKALADIRALVNSGDGTQLKEAMEQAAK 254
633 4.000e-46UniRef50_H0AA87 Prephenate dehydrogenase n=6 Tax=Nanohaloarchaea TaxID=1051663 RepID=H0AA87_HALSG  ali  12  11.......................................................................................GTGKFGQHLGRELEKDNEIVISGKTVD---QASEIAEEYGWGYGES-KEIVKDADIVIIAVPI-AVTVDVIHEVGPHVPEDALLCDITSVKKKPVEAMKEYSD----------EVLGMHPMYAPSIKGQKIVLCPEKGKKWT-LMETFWMDNGADIHVTEPESHDKAMSLVQGLMHFSELVVAETIRKADMTGSDMEEYSSPVYQLITDLTARMLNQPGLYGSIQSENPEN-------------ENIRESFIESAEDIRE 244
634 4.000e-46UniRef50_A0A1V5E8N9 Putative 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Syntrophobacterales TaxID=213462 RepID=A0A1V5E8N9_9DELT  ali  14  24............................................SNMENKRIMVIGAGQMGSGIAQVAAEAGYEVILHDVQADFIQNGIDRIVKALS-------------SKVQKGKIDEAKKQGSRIRGSVSYDEAW-DAQVIIEAVFEDDLKAKIFSVLDGICRSETLFTNTSSIPITRLAASVKRAD-------RFIGIHFFNPPQV--MRLVEIIPGLKTSPDAIQEARQFVDSLKKESVLV-KDVPGFLVNRINAALRLEAYSVEDIDKALKLALGHPMGPFELADFVGLDVGLNVLKTLHDGYKDPKWRPNLLLEKLVLSGDLGRK............... 299
635 4.000e-46UniRef50_Q4FP53 Prephenate dehydrogenase n=30 Tax=cellular organisms TaxID=131567 RepID=Q4FP53_PELUB  ali  14  3..................................................................................NILIIGCGLIGSSLLRAI-SEKKIAKKIFVYEKSKSNILKIKKLKLEITNDLKQIIPNLDLIIFCTPLGEY-EKIILKINRYLLPKTIITDVGSSK-------EKSMDLIKRKLKKGIFWTSSHPIAGSEVSGPELIKEKNTNRKHLLILTKFWKKIGSKVAIMDSKKHDTIFSMTSHLPHLIAYNLVKTATDEKQQRYELIKFS----AGGLRDFSRIAASNEMWRDIFFNNQKNIIKNLRSFKRDIQFKNNKSIIKKLVNTKK 278
636 4.000e-46UniRef50_A0A075KA97 Prephenate dehydrogenase n=2 Tax=Sporomusaceae TaxID=1843490 RepID=A0A075KA97_9FIRM  ali  16  23....................................................................................................KKRCGQDVVVTGIDYDLVTLQQAIERGAVDTNDVRKGVEQADVIFLCTPVLQMLP-IIEEILPYLKIGCIITDVGSTKGFLAEKILDII-------PEGIDYVSGHPMTGIEQSGIIVIPEASTCSKAVQTISQVVTWTGARITTMGLIDHDQCAAIISHVPHVAAAALVNLLGQYP-NLEESFKLVG----GGFRDTTRIASSNAMWADICLTNAQPITDSLLKMKEL-----LDEMIEAVEKSDR 267
637 4.000e-46UniRef50_K1KFK3 Uncharacterized protein n=2 Tax=Sutterella TaxID=40544 RepID=K1KFK3_9BURK  ali  12  10....................................................................................LIGGSAALAWKQAHAEGRFPGGSLSITAVDTNPATLSLALERGIRVTPSIAEGVLDADLVLLAVPVLAM-GAVMKEVDRAAPVDAVITDAGSVRGSVITAV-----RMNARPERIRHYVPLHPIAGAEKAGLEVTPLPESDLEDVALVVDLWRAAGLTVVEMTPEEHDRIYAMVSHVPHMIAFALMDMAVSSPESRTALA-----AAGGGFRDTTRIAAADAMWADITRANRTAILAALTHLKGLVAADDYEGYRTYFERTAE 284
638 4.000e-46UniRef50_W1S067 Prephenate dehydratase n=3 Tax=Marinomonas TaxID=28253 RepID=W1S067_9GAMM  ali  12  20.......................................................................................GLGMIGGSFAKALKERGLATLYGADRRDGELALGVSTGVIDYPAELTAEYVTKMDIIILATPVRAM-ESVLSEIKPYLLPTTLVTDVGSTKGSVIDSARRVFSDVPP------NFIPSHPIAGAEKSGVLAIVTPLSDPVLLDRLHRLWRSVGADVVSMDVEHHDHVLASSSHLPHLLAYTLVDALANGDRSQD-VFKFA----AGGFRDFTRIASSDPMWRDVFMANKDATLATLDHF-----TDRLADMRTAIEQGD. 275
639 4.000e-46UniRef50_A0A1R0GZB2 Putative 3-hydroxyacyl-CoA dehydrogenase n=7 Tax=Opisthokonta TaxID=33154 RepID=A0A1R0GZB2_9FUNG  ali  14  30.....................................PEVVKQKNDSPFEKVTVFGAGLMGSGIAQVSAMSNHQVQLVDLTDEAISKGQAYIMKSLKRIAKKKY------PESQPDQIKFAENIYSRIDFGTNPELAVSNADL-------VEIKRSIFSKLDTVAPSQAIFANTSSLPIGDIFSVL-----PDARKGNTGGLHFFNP--VSQMKLVEVVKGSTTSDETFDKLTRFAIALGKTPVSC-KDTPGFIVNRLLVPYMMEAIRMLERGDASARDIDTPMGPFELLDYVGLDTVKFITNGWE......................................... 294
640 4.000e-46UniRef50_A0A2E6J010 Cyclohexadienyl dehydrogenase n=5 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A2E6J010_9PROT  ali  14  11.......................................................................................GIGLIGSSIARALKK-NKLSKRIHIYSKTKKTINRAKKLGDFYTNNLELSVKNSDLIIICTPLSTY-ESIMLKIYKHIMADAILSDVGSAKLSVVRIFDK-------FKKTKFHILPAHPIAGTEKSGPDCVITPKNNSKSLNKLKKLWVQFGSKVEIMNAKNHDKILALTSHVPHLISYSIVSTLKVNALEKSQIIKFS----AGGLRDFTRIAASDSMWKDIFLSNKKNLLESLKLIKKYIRNNDSQKLKRIFLNTKK 281
641 4.000e-46UniRef50_Q3ABC4 3-hydroxybutyryl-CoA dehydrogenase n=22 Tax=Bacteria TaxID=2 RepID=Q3ABC4_CARHZ  ali  15  1..............................................MEVKKICVVGAGNMGHQISLAAALAGYQVTCTDINEEILNRAKNFVETYLPE-------------RVAKGKLTEEAAAKANLTFTLSLEEACKDVDFVIEAVIEKDVKRELFKKLDELTPPHAILATNSSIVSSKIADVTKRPE-------KVLNMHFFNPALV--MKLVEVVKGPHVADETAEVTMEVARKMGKVPVLLQKEIYGFLVNRILAAIKAEAFYLYEIGIADYKDIDHPMGPFRLMDLTGIDLT................................................. 242
642 4.000e-46UniRef50_U5L8K8 3-hydroxybutyryl-CoA dehydrogenase n=23 Tax=Bacteria TaxID=2 RepID=U5L8K8_9BACI  ali  15  1................................................MKKIVVIGSGVMGRGIAYVSAASGFQTVLVDISDAQLKDAEKEISSIMQK-------------GVQRGKMTENEVSNTKLHFSVSLASNAAEADLIIEAVPERDIKRNIFEVIDQHASEDCIFANTSTMSPTEIGSFTGRPD-------KVLAMHFFNPVH--KMPLVEIVKGLETSDESVEFIRQTAEEMGKETVIIN-EFPGFVTSRISALVGNEAFYMLEIDKAIKLGLHYPMGPFELGDLVGLD--TRLNNLTYLEKLGEKYRPAPLLEQYVKAGRLGRK............... 272
643 5.000e-46UniRef50_A0A087SM58 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Auxenochlorella protothecoides TaxID=3075 RepID=A0A087SM58_AUXPR  ali  14  12.......................................................GAGQMGAGIAQVVASSGIAVKLVDQSHQALDKALAGIESSLARLVTKGRVDAVT------------AEAALGRLYTSTSLEDLHDVDYVVEAVPERDLKLRLFASLDAVAPPHAILANTSSISVTRLGAATRRPAQVL-------GLHFMNP--VPIMGLVELVRGMRTSEDTFRASLALAARLGKQTC-VSADTPGFIVNRLLMPGINEAFYALQEGVGSADDIDRPMGPLALADFIGLDTCLSIMQVLHSGLGDDKYRPCPLLRQHVDAGWLGKK............... 276
644 5.000e-46UniRef50_A0A075WA35 3-hydroxyacyl-CoA dehydrogenase n=9 Tax=cellular organisms TaxID=131567 RepID=A0A075WA35_ARCFL  ali  15  10.......................................................GAGSMGHAIAEVVAIHGFNVKLMDVSEDQLKRAMEKIEEGLRK-------------SYERGYISEDPEKVLRIEATADLIEVAKDADLVIEAIPIFDLKKKVFSEIEQYCPDHTIFTNTSSLSITKLAEATKRPE-------KFIGMHFFNPP--KILKLLEIVWGEKTSEETIRIVEDFARKIDRIIIHVRKDVPGFIVNRIFVTMSNEASWAVEMGEGTIEEIDSAVKYGLPMGLFELHDV................................................. 235
645 5.000e-46UniRef50_A0A0G0C6S5 Uncharacterized protein n=1 Tax=Candidatus Peregrinibacteria bacterium GW2011_GWF2_33_10 TaxID=1619065 RepID=A0A0G0C6S5_9BACT  ali  11  19.....................................................................................................KKNTIGIIGGRGALGAYFAKLFRNGDVKVKLSNEELIKKSDIVIFSVP-LHLATEIIAKNIKFLRKDQLVMDFTSLKSLQIKEMLKSK----------AQVIGMHPMFGPSIKNQIVLYSPAR---TIKKFVKFIKSFGFIVEKIDPQKHDKLMSIVQVLIHFKAIVLGKALENLKIDIKDTLKVASPAYQMELAMVGRIFAQDPLYGAIEIMNPESLEESFNLYKDIILEKDLKKFCKEFEKTSD 269
646 5.000e-46UniRef50_X1JPE7 Uncharacterized protein (Fragment) n=1 Tax=marine sediment metagenome TaxID=412755 RepID=X1JPE7_9ZZZZ  ali  14  24.....................................................................................................KKCGLARRVVGVGHREPSLQAARDCGAEISLDLRAGVAGSDLVVLATPVGKFA-EILQRAVPALEPGAVVIDVGSTKREVVASLEPLVRAPSA-------FVGCHPIAGSEQRGIVVTPTDRTPAETLKRVVATWEGVGMVVRTLSPEVHDRLLAEVSHLPHVIASVLVQAVSGE----------AEPLVGPGWADTTRVASGDPLWRDILMSNADEVAAAIDR...................... 245
647 5.000e-46UniRef50_A0A1E8CI11 Uncharacterized protein n=3 Tax=root TaxID=1 RepID=A0A1E8CI11_9GAMM  ali  12  6................................................................................NKTVLIVGLGLIGGSIARLAASNACQRILAVGRDETVLHTAMLDGSIHAYATDLATLAPEADLIMITVPTQSV-RAILEQLIELVDDSVIITDAASVKGNVVADARQVLRA------RACRFVPGHPIAGSERSGRKVILTPQNDTDAVRTVMALWQCLGADIHAMSAERHDRVLAGTSHLPHLLAFALVNTLVDSISEPDRVQQVFD-YAAGGFADFSRIASSDPMWRDIFLANSDAYIESLQKMRSVLLRADGAAMTREFSRAK. 285
648 5.000e-46UniRef50_Q8TX77 Prephenate dehydrogenase n=2 Tax=Methanopyrus TaxID=2319 RepID=Q8TX77_METKA  ali  12  16..................................................................................................IARELRDDGHEVVITGSNPHTAERARELDVEAAPTNVDAAKDADVVVV-SVPISVTEDVIREVAPHVPEGSLLTDVTSVKVRPVRAMLEH-------APEDVYVLGTHPLFGPTVPGQTVILTPTRSGPWTRRVRRYLERKGARVVETTPEEHDRTMAVVQCLTHAVLLAAGAAIGRFLPSLEDIEEVASPVYRLLMDVVGRIAGQDPLYAEIQAFNPYELLRALRRFHE--HAHDHNALTEYIAESRE 267
649 5.000e-46UniRef50_A0A0F0CJF2 Bifunctional cyclohexadienyl dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase n=1 Tax=Candidatus Omnitrophus magneticus  ali  9  4..................................................................................RLVIIGPGLIGGSLGKAV-IARSLAREVVGVFRQESSLNKALALNAVYISNYEASIKGAEMVVIATPV-HIIKDVLLNLSRVESKGFIVTDVGSTKKEIVDFAKTFSGKFK--------FVGGHPLAGSEKTGVEFVLTKDTDESAVKTVKNLWESTGALVDVLSPSEHDSILAFTSHLPHIVAYSLVNS-----EDSKYSRYMAS-----GFRDTSRIASSDSLWNSILMSNRANVLKNLDILEGAIANGDTELLIKKIKEAQE 272
650 5.000e-46UniRef50_A0A0G1VR42 Prephenate dehydrogenase n=1 Tax=Candidatus Peregrinibacteria bacterium GW2011_GWA2_47_7 TaxID=1619058 RepID=A0A0G1VR42_9BACT  ali  14  42.....................................................................................................................................NRELIERSDIVAFSVPLHQ-TPAIIKKLMPHTRKEQLLIDFASIKTPAIKAMLRSKAS----------VIGLHPMFRPGIKNQTIVMCPARAPETQKFLKNILTRAGAIVTTMNASKHDELMAVVQALTHFRAIVFGNTLRKLRVNIRETLSCMSPVYRLEFDLMGRIFAQDPLYAAIQLHNPKALEEETRRLNELIEQGSMKKFIKMFSKTGK 256
651 5.000e-46UniRef50_A0A2J2HD33 3-hydroxyacyl-CoA dehydrogenase (Fragment) n=2 Tax=TACK group TaxID=1783275 RepID=A0A2J2HD33_9CREN  ali  15  12.......................................................GAGTMGHGIAEVSALAGYEVIIVDVSQDLLNKALERIKWSLDKLAERGTISKDRVGEV-MGR----------IRTSLSVAEAARGADLMIEAVPEKDLKKQVFAEADANAPPHAILTNTSSLPITEIASATKRPD-------RVVGIHFFNPPVL--MPLVEVIKGAQTSDEVARRAYDFVKSLGKEPIMVNKDVPG............................................................................................... 190
652 5.000e-46UniRef50_A0A074LNM6 Prephenate dehydrogenase n=4 Tax=Alicyclobacillaceae TaxID=186823 RepID=A0A074LNM6_9BACL  ali  15  23.......................................................................................GCGLIGGSLA-LALRENGAVQHLAAVDSNPSSCELAVELGVAAYSTLREAVTDADLIVFAAPVRQTCELLAKLAALPLKPGCIVTDVCSTKAEVCAQAARLL-------PSGVHFIGGHPMAGSEKSGVKYVLTPGTDADAFAKLVQAIESVKAQVLVLEPAVHDRVVAAISHVPHIIAAQLVDQVMRLSGHPEHG-GLYTKLAAGGFRDVTRIASGNAMWRDIVLSNRDVIRELLVDWQVGV................. 272
653 6.000e-46UniRef50_A0A1F9BFT6 Uncharacterized protein (Fragment) n=1 Tax=Deltaproteobacteria bacterium RBG_13_60_28 TaxID=1797833 RepID=A0A1F9BFT6_9DELT  ali  14  4........................................................................................................KVALIGGSGQMGKWFQRFFAGQGLEVLVTPQEVAALADVVIVSVPIPQVK-QVVKDVAPHLRPDAALMDFTSVKQVPLAAMLDHFPG---------EVVGTHPLFGPGITGLTMVLCPGRGERWLNWLKALLENAGARVKVTTATEHDRLMSVVQGLSHFTLIALEMAIRQLKVSPQDLEDFATPTFATLHRLAQHLFSQ........................................... 203
654 6.000e-46UniRef50_A0A1W9PT37 Uncharacterized protein n=1 Tax=Desulfococcus sp. 4484_242 TaxID=1968523 RepID=A0A1W9PT37_9DELT  ali  12  2.....................................................................................................KKSNISIIGGVGRMGSWFGRFFETAGHEVVEQIRQAAGRSDVVIVSVPIGE-TCEVIEKVGPYVKAESLLMDLTSLKAEPVEYMLKYSES---------EVIGTHPLFGPDLKDQTVILCPARANRWFAWLTDILSAQGARLEIISPEKHDRIMTIVQAMAHINTMLMGFLIKELNENLSDLKRYSTPLFRVQMALVGRLFAQDPVYAEIIAHNPEVKHAVAVYSALLGDIK.............. 234
655 6.000e-46UniRef50_E7H2X4 Chorismate mutase-t and prephenate dehydrogenase n=3 Tax=Sutterella TaxID=40544 RepID=E7H2X4_9BURK  ali  12  77.......................................................................................................KPVVIVGGAGGMGRQLHRAFERSGWPVRPQAAEILKGAGTVVVSVPIDK-TISVIEALTGLLPREALLCDVTSVKAGPVEAMMRVHRGPVA---------GLHPMFGPDVAGQVFVYAPGRDAAAAEPLLEQIRRWGAKVVTCSAEEHDRSMGIIQALRHFTTFAYGVFLSKLNPDLSVILQLSSPIYRLELEMVGRLFAQDPLYADIILANPRNYVESLAPELAMIEARDRDEFIRRFERVR. 326
656 7.000e-46UniRef50_A0A011N608 Arogenate dehydrogenase n=5 Tax=Betaproteobacteria TaxID=28216 RepID=A0A011N608_9PROT  ali  15  2..............................................................................................................VGFGRRLGSLTQALELGIRAGFNVGQEVSNADLVLIATPVGT-TPDIMARLAPCLGPQTVVTDAGSTKEDVVAAARAHFGERLG------QFVPAHPIAGAENSGVVLTPLPESAPSSIARVRAAWEFCGGLIRELAPAEHDRIFAAVSHLPHLLSFALVHELAR-RDNREQLFAFA----ASGFRDFTRIAASPEMWRDICLANRTALLDELD....................... 219
657 7.000e-46UniRef50_Q63S04 3-phosphoshikimate 1-carboxyvinyltransferase n=123 Tax=Burkholderiaceae TaxID=119060 RepID=Q63S04_BURPS  ali  15  4..........................................................................VVSVFYFDKLVIFGVGLIGGSLAALREGASGGRREVVGVGRSSASIGRALALRVDDDAQLRDALAGADLVLLAAPVAQTGP-LLARIAPFLDASTIVTDAGSTKSDVV------AAARAALGARIGQFVPGHPIAGRESSGVNVVLCPENAPDALARVEAMWRAARADVRAMSAEQHDRVFAAVSHLPHVLSFALVEQILGES---DAELKFS--YAAGGFRDFTRIASSPEMWRDVCLANRAALLDELD....................... 263
658 7.000e-46UniRef50_A0A174BEE0 Arogenate dehydrogenase n=54 Tax=Negativicutes TaxID=909932 RepID=A0A174BEE0_9FIRM  ali  12  5..................................................................................KLAIIGVGLIGGSLGLCLKDKLGEDIYITGLCRHQASMDRAVALGAVASADIESVVSDADIVFLSPPVLQIVPMV-EKILPYLKKGCILTDAGSTKGYIWQHLQKIL-------PDDIYYIAGHPMTGREKSGVDYVIVEDTPPEAHKKLMSVLKYTGANFTTLDIAKHDRCASVISHVPHVTAAALVTLLNRSGDDRDSCIKLIG----GGFRDTTRIASSNAMWADICMTNGEAIASDLRELQAI.................. 255
659 7.000e-46UniRef50_A0A0M0HN53 3-hydroxybutyryl-CoA dehydrogenase n=3 Tax=Vibrio TaxID=662 RepID=A0A0M0HN53_VIBNE  ali  11  12.......................................................GAGTMGAGIAQVAAQSGYQVVLFDLKQGKAEQAKATIAARLEK-------------RVAKGKMSLNEKDALNAMFCSEALHDVAGADLVIEAIVEDAIKQSLFRDLESICREDCLLTNTSSISVTSIASALAKPE-------RFVGLHFFNPA--PLMKLVEVVRGIATSPSVTETAKTWAESCGKHAVI-TRSIPGFIVNRVARPFYAEGLRALETGVAQVQDIDHIMGPFELMDLIGHDVNYAVTKSVYAYYQDKRFLPSLTQKELVEAGYLGRK............... 277
660 8.000e-46UniRef50_A0A1E2VEB7 3-phosphoshikimate 1-carboxyvinyltransferase n=741 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A1E2VEB7_9GAMM  ali  11  15.................................................................................QTLVIVGLGLIGGSVALAARRFTGV-RQVFGVDVNTEELEVARSLGVSSFPDLAHDARDVDLIVLAVPVLAMVK-VLAQVAQHRGPSTVVTDVGSCKAVLRDAAVDALGSMPPW------LVPGHPIAGAERSGVKVIVTPTTDPQAVDQVSAFWASMDAEVLSMALERHDQVLAQTSHLPHLLAFSLVDTLARQDERC-EIFRYA----AGGFRDFTRIAASDPMWRDIFLANRSATLDALDQFLEGVYR............... 273
661 8.000e-46UniRef50_A0A1G1LJY8 Uncharacterized protein n=1 Tax=Omnitrophica bacterium RIFCSPLOWO2_12_FULL_50_11 TaxID=1801834 RepID=A0A1G1LJY8_9BACT  ali  11  20................................................................................................AALRKRFARARVLGVSRSRRKINLAKRLGFIQNGGTSFQKVVSQADIVFVCTPVDTI-GDIVEQVDQAAKPGTIVTDVGSTKGTIVRWA-------DRKRFRNIRFVGSHPLAGSHHGGVFLTPTKKTDRRARRAIASIWKRLGTRVYEMSPNAHDRVVAHVSHLPHGVASCLVNAVSS------NSLRFS----ASGFLDTTRVAADPALWTPIFLTNRVHLACDLKRFRAVV-----DRLIDALSRGAR 261
662 9.000e-46UniRef50_A0A2E6ACQ9 Uncharacterized protein n=4 Tax=Gammaproteobacteria bacterium TaxID=1913989 RepID=A0A2E6ACQ9_9GAMM  ali  9  18...............................................................................MFKKIYIFGLGMMGASLAKAI-RYKKISNKIYGYDINKKNLFYAKKNNIELESNNYEHLSESDFIILCTPISAYKSSM-NIINKYKKDDAIITDIGSTKESI-----DILSKKIFENHNDI-FIGSHPLTGKEISNQIVLLTPNTSTKKINKVTRFWKSLGCKTRIIGAKLHDDILSITSHLPHLVSFALVKIILNKKY-ISKIEEYTG----GGFRDFARLAHSDAMWEDICSNNPKNIVSSLDKLKSNIKNKKFKKLANYFNQTK. 294
663 1.000e-45UniRef50_F2JID8 Prephenate dehydrogenase n=5 Tax=Clostridiales TaxID=186802 RepID=F2JID8_CELLD  ali  12  16................................................................................................AKAIKRVHVQNSYIIGYDTNAADLHSAYDEGMIMATDLKSGFSNCSVVFICTPVTTIK-SVVTELLPYLPNDCILTDVGSTKYHIMQE----LEPMISTDSKRIYYVGGHPMTGSEKFGYSYMLTPLTPDFILFILQKLIERMGGIPLILSATYHDYVTANISHLPHIIASSLVHLVKENDGDAS----YLHTLAAGGFKDLTRIASSNPIWTSICLTNKAQIQRVFSGYLVI-----LQNFLNCLEKDSE 268
664 1.000e-45UniRef50_A0A1F5YV07 Uncharacterized protein n=1 Tax=Candidatus Glassbacteria bacterium RIFCSPLOWO2_12_FULL_58_11 TaxID=1817867 RepID=A0A1F5YV07_9BACT  ali  13  1...................................................................................MAILGVGLIGGSLALAFKRSGKVG-RVWGVSR-RETIEKALALGVITREKTSEALAGADLAVLGAPVEVIIEQ-LGWIGPHLQPGATLTDIGSTKRAIMQAASAQL-------PEEVHFVGGHPMAGAETTGVEYVICPGRDREAAERYSGLVSAIGARVLVTSPEKHDRIAATISHLPQLVAVGLMNLAASANEEDPNTLKLA----AGGFRDLTRIASSPEMWRDICQTN................................ 236
665 1.000e-45UniRef50_J3JP84 Prephenate dehydrogenase n=5 Tax=Streptococcus TaxID=1301 RepID=J3JP84_STRRT  ali  14  9......................................................................................AGLGLIGASLALGIKRGHPDYK-VIGYNRSDKSREVALERGIEATSDFKEFAPLADIIILAVPIKQ-TIDFIKILANLLKENVIITDAGSTKFEIVKAAEHYL------KDKPIQFAGSHPMAGSHKSGAIYIFSPLTKADTIPALQDLLSGLHARYVEIDAAEHDQVTSQISHFPHIIASSLMEQAG----DFSESHEMTKHFAAGGFRDMTRIAESPGMWTSILLTNSQAVLDRIENFKDLIKAKDEDAIWEFFNRGRQ 281
666 1.000e-45UniRef50_F5T3R3 Prephenate dehydrogenase n=4 Tax=Oribacterium TaxID=265975 RepID=F5T3R3_9FIRM  ali  9  10.......................................................................................GLGLIGGSLAKAIKKVYPDT-HISVLDKDSSSVQIALTEGIQELKSFEEIGKDCNLLFLCAPVEE-NRSFLKKLKKQLSPHTLLSDVGSTKTAIMEEAEK--------LGISAQFCGGHPMAGAELSGYKLTPGKDFSSENTEKMKTFLSSIGSIPFVMSPEEHDRSVACVSHLPHLIAASLVKLLK--KEDEKGSMK---KLAAGGFKDISRIASSSPMWQQICLSNKKPILEQLEEIRSSIKKEEPHAIEELFRE... 274
667 1.000e-45UniRef50_A0A2E8XCI5 Cyclohexadienyl dehydrogenase n=1 Tax=Candidatus Marinimicrobia bacterium TaxID=2026760 RepID=A0A2E8XCI5_9BACT  ali  15  26......................................................................................................KKKTKSXIVGYAKTQKTLTXARDLVDXXEENLXKAVXXADXXXLATPLSTFXP-IIREIXPFLKKGXIVTXTGSAKHAVIEELKDLI-------PKDIEFIPGHPIAGTEESGCILTPTKDNSKESINSIKSFWELLGSKVEIMDALHHDKVLAITSHIPHLIAFNIVGTANDLANITDEVVKYS----AGGFRDFTRIAASDPMWSDIFTYNSEAVLEMLDKLKDSILNKDTKMLFSSFEKTR. 281
668 1.000e-45UniRef50_UPI0009919107 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Clostridium botulinum TaxID=1491 RepID=UPI0009919107  ali  15  7.......................................................GAGTMGSGIAQAFAVKGHKVVLRDIKDEFVERGISGVNKSLSKLVKK-----------GKMEEAKKDEILSNITGTVDLN-MAADCDLVVEAAIEMEIKKQIFGELDKICKPQTILANTSSLSITEVASATNRPE-------KVIGMHFFNPA--PVMKLVEVIRGMATSKETFDAVKEISTEIGKEPVEV-AEAPGFVVNRILIPM..................................................................................... 193
669 1.000e-45UniRef50_A0A255GH97 3-hydroxyacyl-CoA dehydrogenase n=7 Tax=Propionibacteriaceae TaxID=31957 RepID=A0A255GH97_9ACTN  ali  13  1...........................................................MGAGIVEVFARAGLTVRGIEYNDQALERGRAILQKSTDRAVAKEKLTADE-----------QTALLGRIEFTTDTAAGVTDADLVIEAVNENELKTSIFQTIDEAAPKTAILANTSSLSVTAIAAAVADPSRVL-------GVHFFNPA--PVQTLVELIRTVHTSDQTIQRMADLLRGLGKSPIVCG-DRAGFIVNALLVPYLGSAIRLEELDQAMVEQAGYPMGPLTLTDLVGNDVTLAVLERMYDETKDRLTAPPSLLRQLVTAGWHGRK............... 262
670 1.000e-45UniRef50_A0A2E2BC53 Prephenate dehydrogenase n=1 Tax=Thiotrichales bacterium TaxID=2026796 RepID=A0A2E2BC53_9GAMM  ali  13  3..................................................................................KIAIIGVGLIGASLGMALRK-NGLANAVVGYGRSSQNLEKAVQLGARFEATIREACVGAEIVVVAASLGA-TASILREVGAXVADGSIITDVGSVKGSVVADARLILGA------KXXXFVPGHPIAGNEKSGAEVILTPTXDTEAVNQIEXLWTELGSEVLKMTVESHXRALAMTSHLPHLLAXNVMDTLLR-QDDSRSLLEFS----AGGFRDFTRIASSNPLWADILLMNKDNIVKFCXEFKSGLEAXDREXIIETFSXAK. 276
671 1.000e-45UniRef50_G4CTI8 Prephenate dehydrogenase n=6 Tax=Neisseria TaxID=482 RepID=G4CTI8_9NEIS  ali  12  13.......................................................................................GVGLIGGSFA-LDLKRKGLVRRVVGVDVNQENLERALER--KVIDEMAECIAGSDLVLIATPVATL-PEICTELAYLLSEQTIVSDVGSTKQSAIQAFARYLPEHLP------NCVAAHPIAGSDRHGAKLILCPHQNPVALSLMQSLWQAVGARTFIMPAEEHDAIFAAVSHMPHVLAFSYVHQIKDHADG-----QLYLDFAASGFRDFTRIASSPAIWTDICLANRQGLLAQLDTVQRLLEAGDSESLYRYFEEAK. 282
672 1.000e-45UniRef50_A0A1M6RQZ2 Prephenate dehydrogenase n=3 Tax=Rubritalea TaxID=361050 RepID=A0A1M6RQZ2_9BACT  ali  13  1...............................................................................MFERVTILGPGLLGGSVALSAVKKLSGCQ-VTLWGRREEPLKVAQSVGIEVTTDLEEAVKEADLVILATPVG-VMPKLVEKIVEVAGEEILLTDVGSVKRMVHEMLAPTLKGTK------IRFVGSHPMAGSEQTGMEAAKCLVTDEDSVKQVEAFWLSLGCRVRRMTAEDHDYAVARVSHFPHVLACVGATVGLAFDDIAD--------LCGGGMRDTTRVAGGDPLWTEIMMENRDALQRSMRELMDMLEKEDREALHAYLDEAKK 275
673 1.000e-45UniRef50_A0A2E4BVW5 Prephenate dehydrogenase n=1 Tax=Dehalococcoidia bacterium TaxID=2026734 RepID=A0A2E4BVW5_9CHLR  ali  12  15..............................................................................................SLGIAIKRSILKDIEITGVDLEPSFSKQARKMGAKVARTMAEVARDSDILFICTPVMAIK-DVLETVGGELKKGCLVTDTGGTKLEVMRWA-------DMFLPDGVDFIGGHPMAGKESHGPAVVPKTGSSTQAVDALLKIIKELGSTPFFIDAAEHDSFVAAVSHLPFIVAASLVNTTGNSPQ-----WGDISKLASTGFRDATRLASGDPMHRDVCLTNGDSIVRELEHIKELIDSRDSNRLDELFETA.. 275
674 1.000e-45UniRef50_A0A1D9GUT3 Prephenate dehydrogenase n=8 Tax=Burkholderiaceae TaxID=119060 RepID=A0A1D9GUT3_9BURK  ali  12  8..................................................................................RVVIVGVGLIGGSLA-LALKRAGVAGKVIGVGRSRASLERAQALGVIDEAAPLEAAKGASLIVLCAPVAQ-TFALLHALEPHLEPGTIVTDAGSTKSDVIMAAKTALGD------KVAQFVPAHPIAGRELNGVEAVLCPLNARADVAAVRAMWEAAGADCHVMSAVQHDAVFAAVSHLPHVLSYALVAQV-ANAEDAALKLDFAG----GGFRDFTRIASSPEMWRDICVANRDALLRELAHLKARIEASDGEGLERVFARASQ 281
675 1.000e-45UniRef50_A0A182MAS9 Kinase n=1 Tax=Anopheles culicifacies TaxID=139723 RepID=A0A182MAS9_9DIPT  ali  16  2.....................................ASSNIKHVTVIGG-------GVMGSGIAMITAANGYRVTVVDVNEDAIGRAKRQVDKDMRRMAQHVSK------GNEQKEHTFYTEAAARMTYSVHLREAVAATDLVIEAIVENEKKQTLFKILDQAAPAHTILANTSSLSIAEIGSSAERKDRIG-------GLHFFNP--VPMMKLIEVVRTDNTSDATHETLLAFGKSLRKTCITCR-DMPGFVVNRLLFPVIHEALGMVEIDVAMKLGLGHPMGPFELMDIVGLDTVCAI--QRERYAADVAAKPSELLERMIYLSETRMNHNEEA.......... 289
676 1.000e-45UniRef50_UPI0003698A02 prephenate dehydrogenase/arogenate dehydrogenase family protein n=2 Tax=Vitreoscilla TaxID=59 RepID=UPI0003698A02  ali  10  1............................................................................MSVLFENVVLIGVGLIGGSLV-LDLKRQQLIGHVHGVDLDAANLERALERHVSASTIMDERITQADLIILATPVGTVA-QIAQALKPWLNHTCTLIDVGSTKQTTIDNIARVLPEHFER------FVATHPIAGSDRHGAKLILCPHTNSDSYQKIWQLWQATGAVVSELSPSEHDEILAMVSHLPHLIAYSYMHAVVGQKLG-EQALDYAG----SGFRDFSRIAASPAIWTDVSFANQDSLLKQLQRLKTLIKQGDAQALYAYYDQAEQ 281
677 1.000e-45UniRef50_A0A1X9M631 3-hydroxyadipyl-CoA dehydrogenase n=10 Tax=Bacteria TaxID=2 RepID=A0A1X9M631_9BACI  ali  13  11.......................................................GSGTMGAGIVQLLIQNGHPTVMFDINQEAVDRARTGIEARLERLVEKQKISVNE----------LTLAKEL-LESTTDIN-AFKDCQLVIEAAPEKGIKRSIFQQLEEICAEDTILTNTSSLSITEIS-------GQIKKPTRVAGLHFFNPA--PIMPLVEVIQGLKTSPEVTETLIDFAKKINKNPVVC-KDTPGFIVNRVARPFYNEALRIMNDQVASVEQIDRIMGPFELQDLIGIDIFATTKSVHAGFHGEDRFRPHYYERMVQSGSLGRKTK.............. 278
678 1.000e-45UniRef50_A0A2V9JL76 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=3 Tax=Acidobacteria bacterium TaxID=1978231 RepID=A0A2V9JL76_9B  ali  12  7................................................................................FQRIAIYGVGLIGGSLGALKKRYARVHIRGVGRDTSRLEKARTMGTIDDFDTDAAHGLEGCDLVILATPVEHI-LQILEKIGSILAPSAVVTDVGSTKRMICRRAWHHL-------PSAVEFVGGHPVAGREVTGVEYILCPHARSENLQRLIHMVEEIGARPAVMDAEEHDQIIAWTSHLPQLISTALANVSSQQETPDNKLIRVTG----SGFQDMIRLAGSPYVWQGILDTNDEALIRQLEKMRADLKGRRL............ 271
679 1.000e-45UniRef50_A0A2A5A0X9 3-hydroxybutyryl-CoA dehydrogenase n=12 Tax=Bacteria TaxID=2 RepID=A0A2A5A0X9_9BACT  ali  13  9.......................................................GAGTMGLGIAQVTAIHGIETILCDLSEDLLSSACSSIAASVEKGIEKGK-------TAPEARENVQQF----LTTSVTTVEACAESNFIIEAVPENELKSRIFQEVEEVCDSAAILTNTSSLPISELASNLKNPQ-------RFIGMHFFNP--VPVMALVEVVRGNVTSQQTVDSVVNLARQLGKEPIVVR-DSPGFATSRLGLVIGLEAIRMLEAGVASAEEIDHPMGPLRLTDLVGLDVRLAIADYLHAEIGEQFRAPDLLREYVNKGRLGKKSGR............. 276
680 1.000e-45UniRef50_A0A1F8SDK0 Uncharacterized protein n=10 Tax=root TaxID=1 RepID=A0A1F8SDK0_9CHLR  ali  15  37............................................................................................................EVVGYVRRHEAGSLALKLGAKVESNLSETVKGANIIIIATPVLTI-RDILSQIAPDLSDDSIVTDTASTKLQVMRWAEELL-------PPEINFVGGHPMAGKETSGVTYCLTPARRAKAVQTVKEMVKGLGATPLTINAEEHDSLVAGVSHLPLLLSVALVSATTKNP-----SWQQMSRLAASGYRDLTRLASNPEVNAGICLSNPTAIVSWIDAF-----SEELQRLRKLVAD... 270
681 1.000e-45UniRef50_Q04983 Cyclohexadienyl dehydrogenase n=9 Tax=Zymomonas mobilis TaxID=542 RepID=TYRC_ZYMMO  ali  14  3...............................................................................VFKHIAIIGLGLIGSSAARATKAYPDVTVSLYDKSEFVRDRARALNLGDNVTDDIQDAVREADLVLLCVPVRAMGI-VAAAMAPALKKDVIICDTGSVKVSVIKTLQDNLPNHI--------IVPSHPLAGTENNGHPVILTPHTPAQAIAYIADYWEEIGGRINLMSAEHHDHVLALTSHLPHVIAYQLIGMVSGYEKKSRTPMRYS----AGSFRDATRVAASEPLWQDIMLENAPALLPVLDHFIADLKKQDGDYLLEHFKESQK 280
682 1.000e-45UniRef50_A0A0B0EQI9 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Candidatus Scalindua brodae TaxID=237368 RepID=A0A0B0EQI9_9BACT  ali  12  18.......................................................GAGTMGSGIAQICAQTGYHVLMIDRHEETARRALIKIDKALSKT----------------TKDEVKQEILSRIKATTNLYEM-EHADLVIEVLTEMELKKEVFRELDNECSKDTIFTNTSSLSVTELSEVLKDPGRL-------VGLHFFNP--VPRMKLVEIIKSKNTSDETVEYAKEVAFELDKTPVI-TGDAPGFIVNRLLLIFLNEAITAADIDKAVTLGLNHPMGPLALSDLIGLDVCKAILDVLYEGYKDPKYKPCTLCEMVEKGILGRKSG--EGFYKY...... 285
683 2.000e-45UniRef50_UPI000D3EB215 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Candidatus Kinetoplastibacterium sorsogonicusi TaxID=1  ali  11  39.....................................................................................................RNKNRVGKVIGVGRNNDSLINAKNLGIIDVISSLEEVSNANMIVISTPVSYFS-SLFKKILPTLNDSVIITDVGSTKVEVIKQAR------LILGKKISQFIPAHPMAGSDESGPKVIITPLEDPSDINYIKNAWNICGANVLKMLPKEHDDVMAAVSHIPHLLSSIYMSCITKS-ENVDLLLS----IAGSGFKDFTRIASSSEMWSDIFLSNKSAVLSYMNSIQLTI-----SDFIKLIENND. 281
684 2.000e-45UniRef50_A0A2H6AK60 Prephenate dehydrogenase n=2 Tax=unclassified Bacteria TaxID=2323 RepID=A0A2H6AK60_9BACT  ali  11  10.......................................................................................GIGLIGGSLAALRKSGRVGEVFGVDVDERALSYAIDKGIVDRGSNKIDE-VRDSEVVVVATHV-RFIPEIVSSLSCIGLKDTVLTDVGSVKESIVKEVERRL-------PSDVYFVGGHPIAGTENSGVVLTPTERTHMRALEIVTAMWEIVGAEVFIMDPKTHDRVFGFLSHLPHVVAYALLNS-TELDEDSRNFVGFAG----GGLRDYTRIASSPDMWSDIFLANKENVLEALERIEVAIKKEDEKELKSELGKA.. 275
685 2.000e-45UniRef50_Q2FQ52 Prephenate dehydrogenase n=6 Tax=Euryarchaeota TaxID=28890 RepID=Q2FQ52_METHJ  ali  11  26.........................................................................................................................EVLIAGRNTPLKKEDIARLADVIVISVPIRD-TVSVIYEIAPLLGEHQILADLTSLKIDPVNAMMCSKAR----------VIGLHPMFGPTIQGQTIVATPARCHEDLSFFQKIFESQGARVTITTAEEHDRMMAVIQGLTHFKAILLAGTMRRLGISPADTESYMSPVYRIETGIAGRLLAQNPLYADILCMNPDTCKQAFDEMLCIIQEGDRNAFTGEFLASRE 251
686 2.000e-45UniRef50_UPI0003B4D558 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Hippea alviniae TaxID=1279027 RepID=UPI0003B4D558  ali  10  18.................................................................................................ALDTRRFGLALKIIGYDANRDNLNKAYSIGIKVANSIDELL-DCDLVVIAVPVSYV-CDILEKLY-FAGYDGLISDVGSIKGKIVKKALKL---------KLYNFIPAHPIAGTENFGPEAAKTDGVDSETLSMVEKFYKSIGMRIVKLSADEHDRIFAFISHMPHAVAYELVELAASKGENFKFI--------GGGFRDFTRIAASSEMWSDIFVMNKDNVVSAIDEFI-----KYMRSLRDLIEKGDK 258
687 2.000e-45UniRef50_A0A1W6LJS8 Arogenate dehydrogenase n=1 Tax=Phycisphaerae bacterium ST-PulAB-D4 TaxID=1941349 RepID=A0A1W6LJS8_9BACT  ali  13  12.......................................................................................GAGLIGGAVGKAVKERLHGC-RVSYYDKSSANAAKAVKLGDKYAAEIEDCVEDAELIIAAAPVGTFK-SIFSKISQFVDEKTVVTDVGSTKVIVSEWAEDILGNGV--------FIGSHPIAGSEKSGIIITPSESVCEEKISFLSDFWEALGMQTSIMTAARHDSIYAVLSHLPHAAAAAMVLS------TPEEFIKYAGK----GFRDTTRIAEGDDIWTDIFMTNSENMLNSLDKLKFFISNNYLSELRDFFEQARE 274
688 2.000e-45UniRef50_A0A091C470 Prephenate dehydrogenase n=2 Tax=Enterococcaceae TaxID=81852 RepID=A0A091C470_9ENTE  ali  14  3................................................................................KQTVMIIGLGLIGSSLACIKKEHPDVLIYGWDNSRNTNKIAIENKVVDLLPKNFDETAQNSDIIVLAVPVNT-TQYYLQKLSKILKKETIITDTSSTKQEIVHTAKYY----------NLNFIGGHPMAGSHKSGIYYIFTPIKEEDQMKQLENLFLGTRAKYILLDPKEHDEITGMLSHLPHIIASGLVNQAEIFKQQHPRAMQLA----AGGFRDITRIASSDPMWTDILLNNREVLLQMLTQW-----QKEMSQLSFWLKNKK. 264
689 2.000e-45UniRef50_R6QW02 Prephenate dehydrogenase n=1 Tax=Butyrivibrio sp. CAG:318 TaxID=1262761 RepID=R6QW02_9FIRM  ali  12  15..............................................................................................SIARAFKKNCP-GIHITAYNRSPEPLARAVSDGIVDTPEVGSGFGDCDIIFLCTPVEH-NLTYLSLLKNIIKPGCIITDVGSVKGYIHRMIHDLGMEEC--------FIGGHPMAGSEKTGYAITPTPLTSDRNLSLYTELVRLTGAIPIITDPDKHDFAVAGISHVPHLIASSLVNLVQDNDTD-DQLMRM---LAAGGFKDMTRIASSSDMWSQICATNPDAIVKLLD....................... 246
690 2.000e-45UniRef50_UPI00082E96DB 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Emergencia timonensis TaxID=1776384 RepID=UPI00082E96DB  ali  15  10.......................................................GSGAMGSGIAQTAITHGIEVMMNDISPELIEKGYFKIKKNLEKA-------------VAKNRMTEDEMRDALGRLCITVEEDAKTADFVIEAATENQIKLDIFKKLDEICKPEAILANTSSIPITEIASVTNRPQ-------QVVGTHFFNP--VPSMKLLELIVGHVTSDQTFAIAEALGKTLDKVTIK-SIDKGGFVVNRLVDPFINEAVFMLEEGVGTAEDIDHPMGPLALGDMIGWDVMLAVMEVLYAEYGDTKYRPAPLMRRMVRAG.................... 269
691 2.000e-45UniRef50_A0A1C5PX42 Arogenate dehydrogenase n=25 Tax=Clostridiales TaxID=186802 RepID=A0A1C5PX42_9FIRM  ali  14  16..............................................................................................SLAKAIRQYYP-DYQIVAFDKNKETLALAESLIDVAATTIDENFRNCGYIFLCAPVS-YNNAYLPQVKPFLDKDTILTDVGSVKTGIHKEVHR--------LGMDANFIGGHPMAGSEKSGYVLTPTKEVSREKVDAYTTLIESLKALPIELDCETHDYVTGTISHLPHIIASSLVNYVKQ----VDTKDELMKLLAAGGFKDITRIASSSPMWQHICLKNKDNILNILDA-----YMDELKQIASIIEDEDE 265
692 2.000e-45UniRef50_A0A1V6FNR6 Prephenate dehydrogenase n=1 Tax=Lentisphaerae bacterium ADurb.Bin082 TaxID=1852899 RepID=A0A1V6FNR6_9BACT  ali  12  31..............................................................................................................IGWSRRPVTCSDALAIGAEAPASLEDAIKAADITVLATP-LAPTVDILREQALNWRRGCLVTDLGSLKHQIVTAAAAAFQGT------GVNFVGSHPMAGTEKSGLEFAPAPGCSREAVRVMADFWELLSCRIYEMDSERHDQLVARTSHVLHILASVLARSILRSDSAKEQRERFCG--CATGFRDISRIAASSPMWREIIELNQSAVLIAMKDFKDLIERGDFDAYEQCFDEGRR 281
693 2.000e-45UniRef50_A0A2E0CJX7 Prephenate dehydrogenase n=2 Tax=Chloroflexi TaxID=200795 RepID=A0A2E0CJX7_9CHLR  ali  16  8.......................................................................................GTGLIGTSIALALKEANINDLDIVGTDYSRDSRIGAQKSGDKIENRLLNAVKDADIVILAVPVMAM-EETMTYIASDLKEGCIVTDVGSTKRVIAEWAASIL-------PENVDYVGGHPMAGKETHGPEIIPSPSASKESVEQISKLAKAVKAEPYYISLDEHDSYVAAVSHLPFVMSTALMQCTSES-----ENWDDISHLAASGFKDITRLASGDPMHKDISVSNAEHIAHWIDMLIT-----NLESFKELLEK... 262
694 2.000e-45UniRef50_E8LHU8 T-protein n=4 Tax=Succinivibrionaceae TaxID=83763 RepID=E8LHU8_SUCHY  ali  12  72..........................................................................LIEDILKRLLRESYRQGGIGVFPCAQKEAKPVLIVGGNGGMGKLLGSFFKNSGYEVRILDKNDWADAETVIVSVPI-DVTAKTIEIISRYLTVDTVLADVTSVKTGPVNAMLKAHSGP---------VIGLHPMFGPDTYKQVVVCVEGRMPDKCEFLVNQLKIWGANICTCKAQDHDRAMSIIQALRHFTTYRYGVFLAKINPDLQNILNLSSPIYRLEIEMVGRLFAQDPLYADIIMSNADLIKESLKSELDIVLSQNKEEFIKRF..... 346
695 2.000e-45UniRef50_A0A255I4K2 Prephenate dehydrogenase n=1 Tax=Lachnotalea glycerini TaxID=1763509 RepID=A0A255I4K2_9FIRM  ali  17  20................................................................................................KAIKAKYPNTKITAYDPNTKSIHFARQEGVVDTIAASIDDAFSCCDFIFLCAPVS-YNITYLTSLKAVIKPECILTDVGSVKTSIHEKVIE--------LELEENFIGGHPMAGSEKTGYEYVLTPSSSEDKIMHYIDYVETLGSIPIVLDYKEHDYVTAAISHLPHIIASSLVNFVEKK----DSSEKIMKNMAAGGFKDITRIASSSPMWQQICLTNKENI-----SLLLNDYIEELSHFKDLIDSACE 266
696 2.000e-45UniRef50_A0A0G3UYF3 3-hydroxyacyl-CoA dehydrogenase n=5 Tax=Actinobacteria TaxID=201174 RepID=A0A0G3UYF3_9ACTN  ali  13  11.......................................................GSGIMGSGIAEVAAKAGFEVVLRSRSQASADGMVVGLTKSLDRQVEK-----------GRLEAAERDAVLARVTAVSDLN-ALADCDLVIESILEDGAKKQLFKELDSIVKAGAILTNTSTLPVVEMAMETARPELV-------CGVHFFNPA--SAMPLVEIVRAITSSDETIATTRGFAEACGKQPVEV-KDQAGFIVNALLFPYLNNAVRLLDAGVANRDDIDTPMGPFALLDLVGLDTSLSILEALYEEFKDPNYAPAPLLRRMVSADRLGRK............... 275
697 2.000e-45UniRef50_A0A257MM89 Prephenate dehydrogenase n=1 Tax=Methanosaeta sp. NSM2 TaxID=1917473 RepID=A0A257MM89_9EURY  ali  15  1....................................................................................................................................................................MRPGSLIMDVTSIKSEPVQAMKS-------YAPVGVEALGTHPMFGPTMPGQTIILTPVKTGRWLAEISSLFQSDGANVEVLDAQEHDRIMAVVQALTHFAYIGIGATLKALQFDVSNSRRFMSPVYEIMIDFVGRILDQNPLYASIQK-NPQAFLSQCMRLCEKADSNDLEGFKQMMREAAE 187
698 2.000e-45UniRef50_A0A1F9Z6R1 Uncharacterized protein n=2 Tax=unclassified Euryarchaeota (miscellaneous) TaxID=115531 RepID=A0A1F9Z6R1_9EURY  ali  13  7.......................................................GAGEMGHGIAELAALRGHDVSMRDIKQEYLDRGMERLRWSLDKLVEKAQVTRPE-----------ADAALARIAPTLDLREALHNADFAIEAVFEDELKKRIFRELDEASPDKTILANTSALPITSMAMVTKRPQ-------KVVGMHFFNPPML--MPLVEVIRADTTSDATLQASVDLAKALGKTVVVVRKDVPGFITTRVLGPYFEEAAWIHEIDAAMRFRAGFPMGPFELADQVGVDVLHHLAGQPE......................................... 250
699 2.000e-45UniRef50_UPI00065DCB33 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Rubeoparvulum massiliense TaxID=1631346 RepID=UPI00065  ali  13  16..............................................................................................SLAKAWQDHPDV--EVVAIDREEETIQQALKDGTIVAGSDEELLVSCDVILLCVPVGQVIPMV-KQLCQLLQSGTIITDTGSTKCGVM-------EGVSEFIQEHLHFIGGHPMAGSHRSGYVITPFPTTPKAAVERLVNLLRITKVNVIEMEWQVHDQVVGAVSHYPHVLAAAMVNMVARYNKD----EPLYHLLAAGGYKDFTRIAASNEMWRDIVLNNRNVLLTYMDELR-----KDLDRLAQAIR.... 263
700 2.000e-45UniRef50_A0A1Y3Q1S1 Uncharacterized protein n=1 Tax=Firmicutes bacterium ZCTH02-B6 TaxID=1861639 RepID=A0A1Y3Q1S1_9FIRM  ali  13  1...........................................................................................MGASMGMALCRAPGV-DRVWGIARRADTVAEAVRVGAVGTTDLRDGVRGADVVVFATPVRTIAALVAEA-APALAAGTVVTDVGSTKAELCRTL-------PPLLPPGVEYVGGHPMCGSERTGLEYIVTPLRPNQGVSRVLALVEAVGAQPLILDAEQHDRAVAAVSHLPHLIATALVLAVGRVAEQDPRVLALA----AGGFRDTTRVASGDAMWRDICLTNRGPILEALDEARRAVAAGDEEALTQHMAEAR. 264
701 3.000e-45UniRef50_A0A2A5DJX5 Prephenate dehydrogenase n=1 Tax=Candidatus Hydrogenedentes bacterium TaxID=2030809 RepID=A0A2A5DJX5_9BACT  ali  15  25.....................................................................................................KARGLATTVRGLGRNASTLEQAKAAGAEIHTDLTDAVIGSDLVVICTP-AATVPDYLDKIRPLCARDMVVTDVASTKGEICSHAREAWADPYR-------FVGSHPMAGSEKWGPEVTLVEAHDPAAHGKVVQLWESVGSRVISIDPDVHDAMVARTSHVPHIAAAAIAQLLKDKPD--------AKPFVGKGFQDTTRIAEGAELWRDICLTNPDAILEGLDDII-----GQLEGVKQAIAEKN. 264
702 3.000e-45UniRef50_A0A2I0QNW9 3-hydroxybutyryl-CoA dehydrogenase n=7 Tax=root TaxID=1 RepID=A0A2I0QNW9_9EURY  ali  11  102.........................................................GVTGTGIAQVLVSAGFEVILKSRTQESLDSAIQKIERELLRTMSVSEKNKIIK----------------NIKPTTNLDDLI-NADIIIESVTENNVKKQLFKELDEILPDKAIITNTSSLSIDELASATARPD-------RFIGMHFFNP--VPKMYLLEIVRGEKTSDTIIDKITKLAKQINKTPII-TKNSPCFIVNRILAAYLNEAISAEDIDTASKLGLNHPMGPLALVDLISLDIVLAILKSLHQRTGDKKYLPCPLIEEVKEGKLGRKTK--EGFYKYI..... 368
703 3.000e-45UniRef50_A0A0W8E6Z2 3-hydroxybutyryl-coa dehydrogenase n=3 Tax=root TaxID=1 RepID=A0A0W8E6Z2_9ZZZZ  ali  14  8.......................................................GAGIMGAGIAQAAAMGGYQVILRDLQMHLVKDGLNTIDKTLNKM-------------VDRSIITEGEKVSANIQGTTDLSD-LRDADLVIEAVVEMSVKKQIFAELDSLCGPNTILTNTSSLSITEIAATTGR-------TTHVLGMHFFNPVHL--LKLVEVIKGLETSDETVQKAMIFCKNIGKHGVLVQRESPGYIVNRI--LLQFINEAIEAIDTAIRLGLGMDLGPLELADKMGLDNLYHIIGFNDEFRD-SKYRPHPLLATMIRGG.................... 268
704 3.000e-45UniRef50_A0A1P8F8S7 3-hydroxybutyryl-CoA dehydrogenase n=7 Tax=Bacteria TaxID=2 RepID=A0A1P8F8S7_9CHLR  ali  12  5.................................................KVGVVGFTGVMGAGIVQLCAQSGYQVVGFSRNQERTKKALATIEKHLSRLVEKEKISP------------ADKAAALARISTSDSMSALADCDLVIESAVEMELKKGVFAELDSVCRPDAILTNTSSLSIIDLAMATHRP-------NQVLGLHFFNPA--PLMPLLEVVRTIATSDETLAIGKAFGESLNKTIIVAR-DAPGYIVNTLLIPYLLNAIRMLDRGQAAREDIDTPMGPLQVADYIGLDALLFIANIMYEESKEPQYAAPPLLKKMVTAGWLGR-KSGKGFYEY...... 283
705 3.000e-45UniRef50_A0A2D6XUC0 Cyclohexadienyl dehydrogenase n=11 Tax=Bacteria TaxID=2 RepID=A0A2D6XUC0_9PROT  ali  12  1...............................................................................MFKKVCIIGCGLIGSSIARAIKK-NNLSVKIVSSNRSDTTNKKVIKLNIXSSSDTKKMVKESDLIIIATPLSSYKSLIFKX-KNSLKNGAILTDVGSV-------XEKXXSLIEKNIPKNVSWISSHPIAGTEESGPEAGFSELFKDRWIKLLKNFWKKIGSRVDIMDAKQHDYILSITSHIPHLIAYNIVNTTLDINEKKKEIVKYS----AGGLRDFTRIAASNPMWRDIFIQNREN............................. 243
706 3.000e-45UniRef50_A0A1I2WHG9 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Desulfotomaculum TaxID=1562 RepID=A0A1I2WHG9_9FIRM  ali  13  13.......................................................GAGNMGHQISLSAALAGYTVICTDINREILQKAENFADTYLPE-------------RVAKGKLAEEDAKAARARFTASLAEAAKDADMVIEAAIEKELKRKIFADLDKICPPHAILATNSSIISSKIADVTGRPE-------KVCNMHFFNPALV--MKLVEVVKGPHVADETVEVAVGVCKKMGKVPVVLQKEIYGFLVNRVVSAIKTEALYIYDMGVATPEDIDHPMGPFRLMDLTGIDLSYYVGMERYQETGDPKYKPSPV............................ 266
707 3.000e-45UniRef50_A0A2H5ZA46 Prephenate dehydrogenase n=1 Tax=bacterium HR29 TaxID=2035424 RepID=A0A2H5ZA46_9BACT  ali  14  8................................................................................RTRITIVGTGLIGASIGLRLCSLPNRTFEVVGIDRDPEQIRTAKKRGAREARSFEDAVEGAGLVVLAVPILA-GPRVMRDLAPYLSPGAVVTDTFSTKNEVLSWAAEYL-------PEGVSFVGGHPMAGKEENGAAIVPSPTASEAAVRTVVGMVEALGARPAYFDAAEHDQLTAAISHLPLFLSVALFRMVRDSP-----SWEDAALLAGPGFRDTTRLASGDPLAQGIWRTNREALLHWLDRFTLQLRE............... 262
708 3.000e-45UniRef50_A0A1Q9NR98 Putative 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Candidatus Heimdallarchaeota archaeon LC_2 TaxID=1841597 RepID=A0A1Q9NR98_9AR  ali  13  10.......................................................GAGLMGSGIAYVTAVSGRNVTIVDQEQQFVDAGMS-----------KIKDQIKDGINRGKMSPHEGQQLSQRFKSTVNLEEAVADSDLVIEAVFEMEVKKKIFSDLSKFTKSECILANTSTLSITEIASVTEKPD-------KVVGLHFFSPVAA--MKLVEIIKGDKTADSTMNQIEAFSDTIGKTSVRCS-DSPGFIVNRIVIPLLNEAVKLLDSGGVTAEDIDKPVGPLTLADYTGIDIALAGLQTLEREFGSCYKPSDTLVKMVEDGKLGMKTK--EGFYKY...... 282
709 3.000e-45UniRef50_A0A2T1DQ28 Bifunctional chorismate mutase/prephenate dehydrogenase n=1 Tax=filamentous cyanobacterium CCP2 TaxID=2107700 RepID=A0A2T1DQ28_9C  ali  12  75..................................................................................................MQSESRKITIVGGRGAMGRFWVDRLTAAGHAVSNEADSLLGNADLVLIAVPLKSMVP-VIRRVAPYLSPQTILADIASTKTEVMQAMLDSHTGP---------VVALHPMFGPGGTGQKVVVCPGRYLPQSQWLLDAIEMDGGTLITCTPEEHDAMMVAVQAIRFFSNFSLGTFYAKEGVDIERSFEFSSPLYRSEINTISRLVAQDALYVDILLASPERLVDTYAHLADLLNQGDRAALIAEFEKTRQ 330
710 3.000e-45UniRef50_A0A0K0F0R6 Probable 3-hydroxyacyl-CoA dehydrogenase (inferred by orthology to a C. elegans protein) n=8 Tax=Protostomia TaxID=33317 RepID=A0  ali  13  1...........................................................MGSGIGQVSAQGKYNVIITDKNEASLHNSKIVISKSIDKVAKK------KFVDNLRDREIFKNEVLDRIKFTTNLKYALCGTDMVIEAITE-DIKQNLFKIIEENTKSDTILTNTSSLSIAKISENLKN-------KQNFCGLHFFNP--VPIMKLLEVIVTNKTSNEVLEALINYGNRIGKVPVKC-KDTPGFIVNRLLYPYLFDAFRLEDIDKAMKLGASHSMGPFELSDFIGLDIIDKIMEQYP......................................... 241
711 3.000e-45UniRef50_A0A1V5C8Y8 Putative 3-hydroxybutyryl-CoA dehydrogenase n=48 Tax=Bacteria TaxID=2 RepID=A0A1V5C8Y8_9DELT  ali  10  10.......................................................GAGTMGHGIAELAALASWEVTLCDISDELLGKALEAIKESLATTERCPDDCATVM---------------QRIKCVISIRDAVGSAGLVIECLPEDELKQKVFRELDRLCAPDVILTNTSGLSPTIIARGLEHPERVVVA-------HFWNPPQL--IPLVEVVPGERTSGEVVDRTMEWVKALGKKPVRMKKECPGFIGNRLQLALLREALYIVEQGYADIEEVDKSIGPFCSADMGGLDVFHRI--SAYLFTELSATKPSGLMQKIVEGGNLGLK............... 274
712 3.000e-45UniRef50_A0A2E9D882 Prephenate dehydrogenase n=3 Tax=Chloroflexi bacterium TaxID=2026724 RepID=A0A2E9D882_9CHLR  ali  13  23..................................................................................................ALKSGKRSDIEIWGYDQDNAVGNKAKKVGAKSVWNLPDAVKEAKIVIITTPVLSV-RQIMEDIAEHLSPGAIVTDTGSTKRVIMDWADEYL-------PENVHFVGGHPMAGRETSGIVVIPHAKADQKAVDSIISMIEYIGAKPYFMDPQEHDSYVGAVSHLPMMLSKALILSTSQSP-SWREIAKLASTGY----KDISRLASGSPMHLDIALTNKDSIIEQLQNIKMLIEKTDVEDIDEKEESMDE 281
713 3.000e-45UniRef50_A0A1W9RMI6 Uncharacterized protein n=1 Tax=candidate division KSB1 bacterium 4484_87 TaxID=1970772 RepID=A0A1W9RMI6_9BACT  ali  12  16............................................................................................GSLLSAFRRKNIGERLLCVDFPRTLERIKKMGLADDLFSPDLSAAVVQADLIFLATRIKTI-EELLPEIVKYSRHGVVITDVGSTKKNVVNIAGKFL-------PPEQYFIGGHPMAGAEKSGIEYILTPETPQTKVNQLAGILGEIGAKVLVLDAETHDRIAAGVSHLPQMLAVSLVNFINRCNEKQPHYLQLA----AGGFRDMTRIASSPDMWEDICRTNEREIVSFLDEFILTDFRDRFNSLKKQFEDAAR 277
714 4.000e-45UniRef50_A0A2T2TB21 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Bacteroidetes bacterium QH_7_62_13 TaxID=1919098 RepID=A0  ali  13  9.......................................................................................GTGLIGGSLALSWQEHRPNGTIVGHDRPDVLTAAEERGAIDEKAADPVTAVEDADLVVLATPLATI-LKLLDTIGGHLPEGCFVTDVGSVKQPVVDQATDVL-------PDHVQFLGGHPMAGAEDAGIEHALPSGGDEDAYAPLIDLIETTGARPLHLAPDRHDRLVAAMSHLPQLLAVALANTAAEADDANGDDGTLALELAGGGFRDMTRIAASPSVWRDILVGNEGAILDAMSSFRRTLRENDLDALEGAFDDARR 285
715 4.000e-45UniRef50_A0A0F5VWU2 Uncharacterized protein n=8 Tax=Actinobacteria TaxID=201174 RepID=A0A0F5VWU2_9ACTN  ali  11  7.......................................................GAGTMGSGIAQLCASTGHVTSLVDTSEEQLGRAATAVTSSLDRFVAKDR----------MTREAADRALS-RLESTTDLERAVSGAQVVVESVVEDAVKQEVLRRTVAAAPAEALLTNTSQLSITAIGSA------VPDHAHRLVGLHFFNPPVL--MRLVEIVQGLVSSEEYVQRAEDFSQGLGKETVICRKDSPGFLTSRISAIVRLECLRMLEEGVASAEDIDRPMGPLELGDFNGLDTYLRILTSLE-GTLGERFKPTVTLRNLVAAGRLGRK............... 273
716 4.000e-45UniRef50_A9WI32 Prephenate dehydrogenase n=7 Tax=Chloroflexi TaxID=200795 RepID=A9WI32_CHLAA  ali  13  30......................................................................................................LGSLEVIGFDREPRVTREARGRLAIDREARTLADAVREAQIVVIATPVRAI-QDVLRDLASHLPAGAIVTDVASTKALVCRWAADLL-------PATVAFVGGHPMAGREQSGPCLTATSTTPAHAVEAVEALVRTVGAKPYYIDPEEHDAYVAGISHLPLLLSVGLVTATGNSP-----AWKEMAPLAATGFRDVSRLASGDPMQRDILLTNPHGLTRWIDELREQIAAGDVAAIEQMLEQAK. 281
717 4.000e-45UniRef50_A0A0W0YNC5 T-protein n=1 Tax=Legionella shakespearei DSM 23087 TaxID=1122169 RepID=A0A0W0YNC5_9GAMM  ali  12  98......................................................................................................ERKIIIIGGRGKMGALFCRQFLLSGYQVEISSPELFSGASLVLVTVPLAK-TLDVINQL-PKLPSDCVLADLTSIKAKPLAAMLKVHDGP---------VVGFHPMFGPRVKKQVVIQCDGRSSEQYGWLVDQIKLWGSYIEACSAKEHDQFMSYIQALRHFTSFVYGCFLLEEQVDLNKVLAFSSPIYRLELAMVGRMFSQPELYADIILSSKDNLAVISRHLKEFS-----NEFNELSHEGRE 337
718 4.000e-45UniRef50_B3R367 PREPHENATE/Arogenate DEHYDROGENASE n=807 Tax=root TaxID=1 RepID=B3R367_CUPTR  ali  13  13..................................................................................RVVIVGVGLIGGSLA-LALKRAGVVGTVVGVGRSAASLQKALDLGIDEAATLADAARGASVIVLCAPVAQ-NFALLHALEPHLQPGTIVTDAGSTKSDVIVAAKTALGD------KAAQFVPAHPIAGRELNGVEAVLCPLNARADVAAVRAMWESAGADCHVMSAVQHDAVFAAVSHLPHVLSYALVAQV-ANAEDAALKLDFAG----GGFRDFTRIASSPEMWRDICVANREALLRELQTLKTLIEKGDGDALERIFTRASK 286
719 4.000e-45UniRef50_A0A1R4K351 3-phosphoshikimate 1-carboxyvinyltransferase n=17 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A1R4K351_9GAMM  ali  13  30.......................................................................................GLGLIGASLAQAI-KDNGLSERLVAVDRHAPSIEEAIKQGLAGSSTLGEVAAGSDLIIIAVPVQAV-QAVFADIKQALASDCMITDVCSTKANIIDAAKAVFTSLPT------GLVPAHPIAGAENSGHSVIICPTTNHVAIAKLRLLWEAVGAKVMPMEATHHDAILAHTSHLPHLLAFNLVEQLASHDDNLD-----MFRYAAGGFRDFTRIAASDPMWHDIFFANQNAIVSALDEMRQLIIDKDSTALMGLLGRAQ. 303
720 4.000e-45UniRef50_A0A1V6HHT9 3-hydroxybutyryl-CoA dehydrogenase n=6 Tax=Bacteria TaxID=2 RepID=A0A1V6HHT9_9BACT  ali  11  12.........................................................GLMGSGIAEVCARAGFETVVREVDDAALARGMDRIRGSLDRAVAK-----------GKLEAAAREAALGRLQTATDF-DALAGCDLVIEAIVENEEKLRTFAALAKVVRPEAIFANTSSLTITQLAAASGRPG-------RTIGLHFFNP--VPVMQLVEVVRTILSDETVVAAATEFCRALGKEPIACR-DNSGFIVNRLLVPYLLDAITVEEIDKGMQLGCGYPMGPFTLLDFVGLDTTYAIANIMFEEYRERRFAPPPLLKQMVLAGHLGRK............... 274
721 4.000e-45UniRef50_UPI000A006699 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Desulfatirhabdium butyrativorans TaxID=340467 RepID=UP  ali  12  50..........................................................................................................................VLSADRKTALTPDDLARRCDVLVLSVPIDA-AVQMARSIGPLLCSSQLLTDVCSLKHEIVAAMRKS---------TLAEVVGMHPLFGPGLKGQNVVLCPVKSSDGFLWLKNVFETQGAMVTVTDPETHDRMMGIVQGLSHWITITIAETVQKSVGSPNQLERFATPVFRLQLGLIGRLLHQDPLYEMLIARNPY--VKEMVEAFQRTGADVLKDFID-FEEG.. 263
722 4.000e-45UniRef50_A0A1C5KS08 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Clostridiales TaxID=186802 RepID=A0A1C5KS08_9FIRM  ali  15  1...........................................................MGSGIVENAASKGLYVTAYDISEKQLEKSLNGISSSLQK-------------SVAKGKLSEQEAKDAIARITTTDISDCKEADVIIEAVAENDIKVSIMKELEKYAREDAIVANTSSISITALAHVFSRPE-------RFVGMHFFSP--VPKMPLMEIVTGYKTGEDTLAKARELGEFMGKSCII-SHDEPGFIVNRMLIPMLNEACILVEIDRGVKLGLHHPMGPLELMDMIGIDVELAVMEVLHEEIGDPKYRPAVSLKRMVDSGFLGKK............... 261
723 4.000e-45UniRef50_A0A2E7HP35 Uncharacterized protein n=1 Tax=Opitutae bacterium TaxID=2026771 RepID=A0A2E7HP35_9BACT  ali  11  3................................................................................FEQVTIVGPGLLGASLA-MALRNRGACRRIVVWARNPERVAECSGLDDHADHSLEKAVSGSDLIVLCTSVESIA-ALIPEVISLSAEGSLLTDVGSVKKKICQVGEEQGGKGKGT------FIGSHPMAGSEKSGMSIVTSPTNVPDSLHRLHDFWERVGMKVHDMSAEEHDRCVAHVSHLPHLLSSSLAHCLDEINLDWRSLCG-------QGLRDTTRIAGNSDLWEQILLSNKSNVLAALAELESSIANEQGSELREFLE.... 273
724 4.000e-45UniRef50_A0A2D5Y6K6 Uncharacterized protein n=1 Tax=Opitutae bacterium TaxID=2026771 RepID=A0A2D5Y6K6_9BACT  ali  12  11..................................................................................RVTIVGPGLLGGSIG-MALREKGITGEIWAYLRDEKKRQTCTNLCDRAVLNLQEAVQESELVVLCTPVETILDH-LPMLSGWVKTGCLITDIGSLKKEICECAHRWFKDRPSS------FVGSHPMTGSEKNGIEFIVTPETDTDSCQIISRMWQALGMKVTKINPELHDEIVAWVSHLPHIIASGLINAINXKNE---KWIXFCGN----GLKDTTRVASNPEMWKQIIMGNKDNVTAMVEELNLIKKANDREXLMEILDSAK. 282
725 4.000e-45UniRef50_M1L747 Prephenate dehydrogenase n=5 Tax=Candidatus Kinetoplastibacterium TaxID=33055 RepID=M1L747_9PROT  ali  11  24.......................................................................................GVGLIGGSFA-LAARKSGFAKHIIGVGRNKSSLIRACDLGIDDFMTIDEATKQSDFILLSTPVG-FLSDLLKSIKPFLGDNTVITDVGSTKLEVINIAISILGKQIS------QFVPGHPIAGLEKSGPEVILTPNNTKKDIELISRAWELCGSNVILMSAKAHDHLLASISHIPHFLSSMYMAQVASSEDS-----DLRLRIAGSGFRDFTRIASSVEMWLDIFFSNKSAISKIINQAEEAIDCNDRDSLRIILERAAQ 292
726 4.000e-45UniRef50_A0A2A4PGP4 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Planctomycetes bacterium TaxID=2026780 RepID=A0A2A4PGP4_9BACT  ali  10  19.......................................................GAGTMGAGIAQVLAQSGIRTVLFDVSQEAVDAGLERIEKMLQK-------------GVERGKLNADVRQQALISMQLDLAAAVDGCQLVIEAAPEKELKQSLFAQIGAVVDDNCIIANASSLSVSTLAESCPHPE-------RFIGLHFFNPP--PIMKLLEIVRGAQTSDAIVEQCRILASDWGKEPIVVR-DAPGFASSRLGLAIGLEAMRMVDEGVASPTDIDKPMGPLELTDMIGLDDIARHLAE-ELNADRFAT-PKGLRERVENGNLGRKSG.............. 286
727 4.000e-45UniRef50_A0A0H5BX50 T-protein n=1 Tax=Candidatus Westeberhardia cardiocondylae TaxID=1594731 RepID=A0A0H5BX50_9ENTR  ali  10  69.........................................................................DLIENILRCIINESYKHETNIGFKKIQKNINKIVIIGGNGKMGLLFEKMLSLSGYTVLLNIEILLKHVNLVIISVPIHS-TIKIIKKL-PTLPKDCILMDLTSIKYEPIQTMLSSHTGP---------VLGMHPIFGPDISKQTIVYCNGRYPESYQWILDQIKIWGANLQCMKPIEHDKIMSYIQSLRQFIHFIYGIFLKEKKQDIKKLIMFSTPIYRTELIMVMRLFSQNPLCYDIITNSKHNFEKYIKKTINLIKSCKNQEFLKIFTETKD 348
728 4.000e-45UniRef50_A0A139WZS2 Chorismate mutase n=1 Tax=Scytonema hofmannii PCC 7110 TaxID=128403 RepID=A0A139WZS2_9CYAN  ali  13  2.....................................................................................................KSQRVTVIGGGGKMGRFFTQWLTALGHHISNDWERALADADLVLICVPI-ECSLEVIRKVTQYLSPTTALADITSIKAPAVRAMLKHHTGP---------VMGLHPMFGPSIQSQIVVVCPGRGDESFQWLLNLIEGEGGKVMFSTPEEHDQMMVVIQAIRHFATLSFGIFLSEEKIDIRRSLDFSSPVYRQQIDIVNRLLTQSALVVDIMLERREAIVRTYSRLAQLVMQGDREALLLELKAVN. 253
729 4.000e-45UniRef50_D0D030 3-hydroxybutyryl-coa dehydrogenase n=2 Tax=Citreicella sp. SE45 TaxID=501479 RepID=D0D030_9RHOB  ali  13  360.......................................................GAGQMGNGIAHVMALAGYEVRLSDVSQEALDKAIALIGRNLDR-------------QVSREKISQDERDQARISVTLDIA-AVGQTDLVIEAATEQEVKQKIFDSLAPHLLPNTILTNTSSISITRLASRTDRPE-------KFLGFHFMNP--VPLMQLVELIRGIATDKETYETCLGVVERLGKT--AASAEDPAFIVNRILVPMINEAYTLYEIDMAMKLGANHPMGPLELADFIGLDTCLAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRK............... 624
730 4.000e-45UniRef50_A0A2A4T414 Uncharacterized protein (Fragment) n=1 Tax=SAR324 cluster bacterium TaxID=2024889 RepID=A0A2A4T414_9DELT  ali  12  25.......................................................................................................DRIGIIGGSGQMGRMFEKHFKALGKIVTVSDEKLVIESDLVIISVPLGAAK-EVIKRIKPWLRKDQLLSDFTSVKTKVVPAMLE----------TEASVISCHPMFGSEIKGQNIVLMPVRPGKFQAKLRRLYEDLGLSVVVMDWKKHDQSMSFIQGLMHFLHIVFTQTLHSKDVDLKTLLSICSPVYQANFAFACRILQRDPLYTHILMDNPE.............................. 238
731 5.000e-45UniRef50_A0A1X0N1W8 Prephenate dehydrogenase n=2 Tax=Pseudomonas TaxID=286 RepID=A0A1X0N1W8_9PSED  ali  12  16..................................................................................RLVVVGLGLIGGSFAKGV-RESGLCREVVGVDLDPQSRELAVELGVRCEEDLAAACCGADVIQLAVPILAMEKLLALLAPLDLGS-AVLTDVGSAKGNVVRAARLAFGQMPSR------FVPGHPIAGSEQSGVEVILTPLTDVDAVALVDRLWSALGADVEHMQVERHDEVLAATSHLPHLLAFGLVDSLAKRNENL-EIFRYA----AGGFRDFTRIAGSDPMWHDIFLANRDAVLRTLDTFRS-----DLDALRDAVSAGD. 277
732 5.000e-45UniRef50_A0A2A9HEZ3 3-hydroxyacyl-CoA dehydrogenase n=3 Tax=Chloroflexi TaxID=200795 RepID=A0A2A9HEZ3_9CHLR  ali  11  10.......................................................GAGLMGSGIAQVAAYHGLDVTLVDVDQAHVDRAIAAIRARLEREAERGRISAEAAEAAS---------HRLRGSADITDLTSVARAEAVIEAVVEDEVKTRIFRQLGRVCRPDALLANTSSLPLSDLAAASGRPE-------RVIGLHFFNPPWA--LKLVEVVSTASTTEETLQDALQLCRQLDRVTVQV-KDTPGFIANRLLVPFIFDAIELLQTGVASAEDIDHAMGPLATADLIGLDTLKAIAESMFEEYGEPRFKAPTLLRRLVSLGYLGRK............... 277
733 5.000e-45UniRef50_A0A1W9P9V6 Cytidylate kinase n=1 Tax=Candidatus Omnitrophica bacterium 4484_213 TaxID=1968528 RepID=A0A1W9P9V6_9BACT  ali  11  11.......................................................................................GTGLIGGSLG-LVIKRKKLARQVFGIAKHEKTIEEAVKLGAIDKGSLKKDAQESELIIICTPVGEVVSTV-QKIIPFLRAGSLITDVGSTKKKITQEIERIL-------PREIHFVGGHPLAGSEKKGVRLIKSKKTDIAALKKVKQLWEEVGSRAKITSAAQHDKIVAEISHLPHIAAVSLVNSVS------ERYLKYA----AKGWKDSTRIALSDALRRDICIDNKEEISRALEAMRDLIQKGDSQEITKEFKKARQ 273
734 5.000e-45UniRef50_A0A1X6WNQ4 Prephenate dehydrogenase n=2 Tax=Vagococcus fluvialis TaxID=2738 RepID=A0A1X6WNQ4_9ENTE  ali  12  3..................................................................................NILMIGIGLIGSSVACLKGKNKELRIVGFSENIEELIGAYQHKIIDDYTQNFKQACEQADVIFFCTPVS-ITLSLMPKIVHFLKKNVLITDVGSTKGEILETAKEVFKNKY-------DFIGGHPMAGSHKSGYILVPNDGVSAEKVAQLKSLLRLTKAKFIELDASEHDKMTGILSHMPHIIASQLVTQADNLMEELPMAKKLA----AGGFRDITRIASSNPMWVDISISNRYILIEEIERIKVKLATGDRKELYQFFEEAKK 278
735 5.000e-45UniRef50_A0A2N6QCE7 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=3 Tax=Oligella TaxID=90243 RepID=A0A2N6QCE7_9BURK  ali  13  50.................................................................................................ALAMKSAGLCERVIAAGRQQSSLFNAKALGVIDEVVSVELAAEADLIFIAVPVKAFA-SVFKQLIPHLSETAIITDGGSTKYDLM------MEARLILGERIGQFVPLHPIAGSHQSGVAAARGDLYEDRKLALLAATWQALGATVYCMDAQIHDRIFAATSHFPHYISAAYMNSLLASEH-----RELFLAMAGTGFRDFTRIASSPEMWSDIFFANKEAMLAQLDDFI.................... 282
736 5.000e-45UniRef50_M1ZAZ0 3-hydroxybutyryl-CoA dehydrogenase n=4 Tax=Nitrospina TaxID=35800 RepID=M1ZAZ0_NITG3  ali  12  10.......................................................GAGQMGSGIAQVLAEAGLGVLLYDSVPRQVEKGLDAIRLRLEK-------------KVTKGDLTEARMQDARVVGVKTLKE-LHDAEFVIEAVVEDALKKKLFEWLAEVVDPSAILANTSSIPITELAAVTRHPENV-------IGFHFMNPPFL--MPGIEIVRGLLTSDATFDAARELAEHLGKQAV-VSKDRAGFVVNRIVMPMINEAVLLVGEGTASIEDIDHPMGPLALSDTIGNDTTHHILSVMQREHGD-RFRPAPLLTRMVEAGMFGRK............... 273
737 5.000e-45UniRef50_Q8DUW0 Putative prephenate dehydrogenase n=866 Tax=root TaxID=1 RepID=Q8DUW0_STRMU  ali  15  6...................................................................................IYIAGLGLIGASLA-LGIKRDHPHYKIVGYNRSDRSRDIALERGIEATADFKVFAALADVIILAVPIKK-TIDFIKILADLLKEDVIITDAGSTKYEIVRAAEYYL------KDKPVQFVGSHPMAGSHKSGAVYIFSPLTKPNTIPALQDLLSGLHARYVEIDAAEHDCVTSQISHFPHIIASSLM----KQAGDFSESHEMTKHFAAGGFRDMTRIAESPGMWTSILLTNQEAVLDRIENF-----KQRLDEVSNLIKARDE 269
738 5.000e-45UniRef50_A0A146GCC1 3-phosphoshikimate 1-carboxyvinyltransferase n=4 Tax=Verrucomicrobia TaxID=74201 RepID=A0A146GCC1_9BACT  ali  15  8................................................................................................................................HVFTDPAAAAEGADICVFCTPIGAM-ETIAKVIAPVMASHGIVTDAGSVKGSVVHTLEPIFGGR---------FVGSHPMAGSERSGIVVTPTEKSDPRAVSEVESLWRDVGCRIVTMSPDEHDESVARISHLPHAAAAALVNA-------INRRLPEAQKIAGGGYRDTTRIAAGPPMWSEILLENKAALIATLEELKALLHSHDAAALEAYLSRAKE 230
739 5.000e-45UniRef50_A0A1Z8RJW6 Uncharacterized protein n=1 Tax=Verrucomicrobia bacterium TMED40 TaxID=1986790 RepID=A0A1Z8RJW6_9BACT  ali  10  3...............................................................................IFEQVAILGPGLLGASLA-MAVRERQICERIFIWGRKEQRLERAMEWCDFADRDLEKVLAGSDLIVCCTPVESI-QEMLREMMPKTGKDILVTDVGSVKESICTEAKQA------SNEESGTFIGSHPMAGSEKSGMEFILTPMEDPDRTAKLVEFWELLGMQTLIESPQTHDKIVANVSHLPHLLASSLARYLSQCSKGWMAASG-------QGLRDTTRVAEGDGLWLEIMKANQSKLMKSLEEAKEFLRQGDWENLEKFLSEAAD 278
740 5.000e-45UniRef50_A0A1F4Q437 Uncharacterized protein n=2 Tax=unclassified candidate division NC10 TaxID=1207073 RepID=A0A1F4Q437_9BACT  ali  8  1...............................................................................MFREMVVVGVGLIGGSLA-LAARKAGLVETVVGVEADPAHREMALAAGVRVTERLSGDLARADLVVLAVPVTGIA-ALLPEVARFASETCLVTDVGSVKGPILAAGDAAFP--------DGRFVAGHPIAGRERSGPIVTPSTRTRADAVDRVAALWRGVGTQVVTMEAGWHDEVFATVSHLPHLVAYALMDAVLGMARGEERLK-----FSAGGLRDFTRVAASHPMWRDIFLMNREQILRALAGLEAAIRDGDGEALTARLSRAR. 275
741 6.000e-45UniRef50_A0A1U7GFK2 Prephenate dehydrogenase n=2 Tax=Planctomycetales TaxID=112 RepID=A0A1U7GFK2_9BACT  ali  13  43.....................................................................................................RARGLAREVVGVGRDMARLEEARGHGARATVDMASGLAEADVVVVCTPVGRVAEDV-RRASEIAPRSALITDAGSTKRTIVEAVEKSPRAAEM-------FVAAHPMAGSEKTGCVLTPSPRTPRGLVGRAREFWSSLGCRTVEMGPAEHDEVVAFTSHLPHALAASLAGSVPAD----------WHALAAGAFRDVTRVAGADELWTAIFRENRGPLMNAI-----GKLQDRLSAL......... 272
742 6.000e-45UniRef50_W0JEA0 Prephenate dehydrogenase n=3 Tax=Desulfurella TaxID=33001 RepID=W0JEA0_DESAE  ali  13  34.....................................................................................................KHKKLSKIIIGYDNNQENLDDALNLLIDIGANSYKSFSICDFVIVSVPPSQ-TAHVVIQLFEVLKENTIVIDVASIKKPIIDSIKN-------YIPKTIAYVPTHPIAGTENFGPKFIITPINNSFAEKKVEEFAKTINMKVKYMDADKHDKVFAYVSHLPHAIAYSLVNLIRQKKED-DEAYGFIG----GGFKDFTRIAKSNEMWCDIFLLNQSNMINAIDELKDAIKNNEEQELIQILKNIR. 286
743 6.000e-45UniRef50_A0A1U7CYR3 Prephenate dehydrogenase n=4 Tax=Isosphaeraceae TaxID=1763524 RepID=A0A1U7CYR3_9BACT  ali  11  24.....................................................................................................RSRGLASTVVGVGRDLQALEQARHRGVRATTDLAQGVAEADVVVVCTPVGRVALDV-RRASESAPKTALITDAGSTKRRIVEEVEKTPSAAEL-------FVGAHPLAGSERSGCVLTPTAKTPASRLRAARGFWSSLGCRILEMGPVEHDEVVAYTSHLPHALAASLAATVPVD----------WLPLAAGAFRDGSRVAGADELWTAIFRENRGPLMDRLATLKYALMNDDEDAIRRWWDDAR. 273
744 8.000e-44UniRef50_A0A182N3R1 Uncharacterized protein n=1 Tax=Anopheles dirus TaxID=7168 RepID=A0A182N3R1_9DIPT  ali  14  299.................SGEGFYSYKKKCKSARPYFVRVLAMASSKISHVTVI--GGGVMGSGIAMITAANGYRVTVVDVSEEALGRARRQVEKDLQRTTQYFSKGNDQVAEKLYSEAT------ARLKYSTNLKEVAATTDLVIEAIVENQLKQSLFKTLDQVAPPHTILTNTSSLSVAEIGLSAERKDRIG-------GLHFFNP--VPLMRLIEVVRTGETSDGTHETLLAFGKSLRKTCITCR-DTPGFVVNRLLLPVTQEALAMVERGDASTHDIDHPMGPFELMDIVGLDTVRPLIATRRLRDESHLDN................................ 607
745 3.000e-42UniRef50_A0A182IWN4 Uncharacterized protein n=1 Tax=Anopheles atroparvus TaxID=41427 RepID=A0A182IWN4_9DIPT  ali  14  353.......................................................GGGIMGSGIAMITAANGYQVTVVDVNEEALSRARLQVEKDLRRM-------AMHVSKGNEEAANKFYADGARLSYSADLEQVVSKTDLVIEAIVENEKKQALFKVIDQVALPHTLITNTSSLSVKEIGSTARRQDRIG-------GLHFFNP--VPLMKLVEVIRTEQTSNNTHEALLAFAKSLRKTTVSC-KDLPGFVVNRLLFPVISEALGMVEIDVAMKLGLGHPMGPFELMDIVGIDTVQSIQQQ----RRDGAIKPSALLDAME....................... 611
746 4.000e-42UniRef50_E6S6D9 3-hydroxyacyl-CoA dehydrogenase n=1153 Tax=root TaxID=1 RepID=E6S6D9_INTC7  ali  12  14.........................................................GTMGAGIVEVFARNGIDVVAVEVDDDAVERGREHLTNSTGRA-------------VARGKLSEEDQATLVSRVFTSEMAALKDCQLVIEAVPEKELKKEIFAKLDAIVAEDAILTNTSSLPVTEIAVATSNP-------KRVVGMHFFNPA--PVMQFVEVIKTVVTADDIFERVKGLAERLGKRPVVVG-DKAGFIANALLFLNHAVSATREDIDAAMKLGCGYPMGPLALMDLIGLDTAYEILDTMYKQGRDRLHAPSPIIKQMVSAGLRGRK............... 276
747 4.000e-42UniRef50_F6BDH9 Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase-related protein n=11 Tax=Methanococcales TaxID=2182 RepI  ali  28  61.......................................................................................................................WKVVEDAGVKVVSDDIEAAKNAEIAILFTPFGKKTFQIAKNILPYLPQNAVIANTCTVSPIVLYSMLEV---DLRTKRKDVGITSMHPAAVPGTPGHYVISGKATDEEQVNKCVELAESAGKKAYVVPADVSSTVADMGSLVTAVALAGVLDYYTVGKKIINAPEKMIEKQIIMTLQTMASLVETSGVKGLLKALNPELLIRSASSMHLLKDQKDLDAA......... 284
748 4.000e-42UniRef50_Q58125 H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ0715 n=5 Tax=Methanocaldococcus TaxID=196118 RepID=HMDX  ali  28  61.......................................................................................................................WKKVEDAGVKVVSDDIEAAKHGEIHVLFTPFGRITLNIANTIIEHVPENAIICNTCTIPTPVLY---RSLEGILRLKRRDVGISSMHPTGVPGTPSQKYYGKEYATEDQINKLVELVKSVGKIPYVTPADVVPAVADMGALVTAVALVGVLDYYRVGTQIINAPKDMIEKQILISLQTIASIIETSGMEGLMKVFNKDALLSSAKNMLIDERQEDLNLALKIIEEFDK 293
749 7.000e-41UniRef50_A0A1F7B359 Uncharacterized protein n=1 Tax=Candidatus Peregrinibacteria bacterium RIFOXYB2_FULL_32_7 TaxID=1801906 RepID=A0A1F7B359_9BACT :_  ali  13  37..........................................................................................................................ISDLGTKL--SNQQLIEKSDVVIFSVP-LHLSTKIILENLKFLRKDQLVMDFTSLKQEQVTAMMKSKA----------EVMGMHPLFGPNVKGQVILYCPERT-KQEKKFVNFMEKFGFTMKEISPQKHDHLMAIIQVLIHFKAIVLGKALEKLGVDIKESLAISSPIYKMELNMIGRIFAQDPLYGAIEIMNPEILEESFDLYKEIVLKKDLVKFEKEFVKTSK 257
750 8.000e-41UniRef50_A0A182FTX9 Uncharacterized protein n=2 Tax=Anopheles TaxID=44484 RepID=A0A182FTX9_ANOAL  ali  14  288.................................................................LVTAANGYRVTVVDVNDEVLASAQRDLEKNLKRTAMHVTK------GDAKAAQAFFTEAKARLSFSTDLKQTVSSTDLVIEAIVEKEAKQNLFSIADQVAPPHTILANTSSLSIADIGAKTKRQDRVG-------GLHFFNP--VPMMKLVEVIRTDRTSDRTHETLLAFGKSVRKTCITC-KDTPGFVVNRLLFPVVTEALAMVEIDIAMKLGLGHPMGPFELMDIVGLDTVQNI.............................................. 517
751 3.000e-40UniRef50_Q58734 H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 n=10 Tax=Euryarchaeota TaxID=28890 RepID=HMDY_METJ  ali  27  72.......................................................................................................................WKKVEDAGVKVVSDDVEAAKHGEIHVLFTPFGKATFRIAKTIIEHVPENAVICNTCTVSPVVLYYSLEP---ILRTKRKDVGISSMHPAAVPGTPGHYVIGGKTTDEEQIKKAVELAKSAGKEAYVVPADVSSVVADMGSLVTAVALSGVLDYYTVGRKIINAPKKMIEQQVIMTLQTMASLVETSGIEGMVKALNPELLIRSASSMKLLDRQKDLDAA......... 295
752 2.000e-39UniRef50_A0A1D2WNB6 Prephenate dehydrogenase n=2 Tax=Methanobrevibacter TaxID=2172 RepID=A0A1D2WNB6_9EURY  ali  13  45............................................................................................................................NLNVNYIESNTDLAKISDIIIVSVPIHH-TSDVIREVAQFMKAGSLMIDVTSVKEEPSRTMEEVL-------PDTVEYIPTHPIFGPELDNQVIVLTATKKGEWYRKVYDYLNKQHMRIIETTAKKHDYMMSIVQVLTHFSFISTASAIEKLKIDISETEDYESPIYNLMIDMIARIVAQNPLTYHIQSMNPKIRNTFADELRDVINNEDDEKFVEIAIKATK 269
753 4.000e-39UniRef50_A0A1F7AUQ0 Prephenate dehydratase n=4 Tax=root TaxID=1 RepID=A0A1F7AUQ0_9BACT  ali  12  18..................................................................................................................MGSVFADFFEGLGYKVLISDAELVKKSNVVIVSVPIDK-TIEVIKSIVPLLKKDQLLMDFTSLKEAPIAEMLKSKAS----------VIGLHPMFGNSTPGQKILVSPARSGKWMPWIKEVFEEKGFILKTISPQDHDKLMSLEQVLVHFTDFAFCKALQERGVKVEDILYYATPAAGLKMEMAARLLSQDGLYANIQINNKYSLLKTSAELFYLVKNKDLKGFMNYFNTAGE 256
754 5.000e-39UniRef50_I7KDK7 Prephenate dehydrogenase n=12 Tax=Methanomicrobiales TaxID=2191 RepID=I7KDK7_METBM  ali  11  31..............................................................................................................................GTKTPLTNRDVAEMADLVMVSVPI-RATVGVIQEVAGLLSEEQVFCDLTSLKVEPVRAMLASRA----------EVIGLHPMFGPGLRGQTIVATPARDPATLEGLLSVFRDQGAAITLSTPEDHDRMMAVIQGLTHFGTLAKAEAIRRTGADVDETLSFTSPIYRIEMGLVGRLLAQDGLYGDMLLMNPAAFEDAVRTLRAIVEGGDDEQFRAFFAE... 248
755 6.000e-39UniRef50_A0A2E7Y7H6 Bifunctional chorismate mutase/prephenate dehydrogenase n=4 Tax=Planctomycetes TaxID=203682 RepID=A0A2E7Y7H6_9PLAN  ali  14  72...........................................................DRSGLNPEVTESLFRLVLWASRNRQAQLHAAVPQDLTSQ------RVAVIGAEGGMGTMMSGLLQDLGNEVTLTIEQAAASADVVLVSVDIRE-TEEVIRRAGPHLCEDSLFTDVTSTKHDPVAAMLASSTAS---------VIGTHPLFGPGLQGQRIAITPGRGTDWMTWLTSTLRAAGLTLLETTPEDHDRVMAVVQVLTHFSTEVIGRTMEHLDVSIEETLRFTSPIYHLELLMTARHFAQSPLYSAIQMSNP............................... 326
756 8.000e-39UniRef50_A0A2E0TQZ6 Bifunctional chorismate mutase/prephenate dehydrogenase n=2 Tax=Sandaracinus sp. TaxID=2024858 RepID=A0A2E0TQZ6_9DELT  ali  14  79....................................................................IESVYRMLLLASRDRQAELRAEVPEDLEPR------TVAILGGEGGMGQSLARMFGDLGHAVLVSDLEAAKIADVVVVSVPI-RVTEEVIREVGPHVREDALLMDVTSVKQAPLAAMLAATE------KSGASVVGTHPMFGPGVHGQRVVVCPGRGDGWLAWARETFRSRGMVVTDASAEEHDRVMSVVQVLNHFQTQVMGLALSRVGVPLARTLAYTSPAYLLEAYVVGRHFAQSPLYGPIEMLNPE.............................. 325
757 8.000e-39UniRef50_A0A1F7BWR7 Uncharacterized protein n=1 Tax=Candidatus Peribacteria bacterium RIFCSPHIGHO2_02_FULL_51_15 TaxID=1801919 RepID=A0A1F7BWR7_9BACT  ali  9  32.........................................................................................................................KVMTTGSKDSDNNKKLMRGCDIVIFSVPLMHSTRIIEREIVYAVRKNQLLLDVSSLKYRQCRALKKAAG----------EVIGMHPLFGPTTEGQTIVLCPVCNKETLRSLQDFFASLGIRPIVMTAEKHDHLMAVLQVLPHLKSLLVADVLKIGGDIIDTINETATPAYRIELNLVGRFLDDDPLYGPIILDNPETLRRSLSEITEMLKGNDLRAFAK....... 251
758 2.000e-38UniRef50_D1JF05 Putative prephenate dehydrogenase n=2 Tax=Archaea TaxID=2157 RepID=D1JF05_9ARCH  ali  15  45........................................................................................................................EIAKRLGVRFSNTDVEEILDADVVLISVPI-DITARVIERVGPKMHTGSLLMDITTVKKMPMETMQ-------RCTSAGVEILGTHPLFGPSMQGQTVIFVPSKKGQLYERIYELFESTGAKIELLTAAEHDKIMAVIQGLTHFVLISFGIALKNLDFDVVESRRYMNPMVAILMDFVGRLLHQDPLSAMIQTNFEEAFLSGANRLFELVSAGNVEEFM........ 271
759 3.000e-38UniRef50_C1A8E2 Chorismate mutase/prephenate dehydrogenase n=7 Tax=Bacteria TaxID=2 RepID=C1A8E2_GEMAT  ali  9  141.............................................................................................................................................DVTVISVPI-ELTERVIREVGPHVRAESLLMDVTSIKEAPMRAMLESTTAS---------VVGTHPMFGPSVQGQRVVVCRGRGDTWADWVSRTLAARGLVVTETTPEQHDRAMSVVQVLTHFQTQVLGLTLARIGVPLAETMPFTSPAYLLELYVAARHFAQDPLYGSIEMRNPAAFGAAVQELARVIADGDQAAFTSLFQDVR. 345
760 3.000e-38UniRef50_A0A1W9TQS6 Uncharacterized protein n=1 Tax=Desulfobacteraceae bacterium 4572_187 TaxID=1971620 RepID=A0A1W9TQS6_9DELT  ali  13  25...................................................................................................................GAGHRILISDLKTKLR--PKDIAKKSDVVILSVP-LDTALSLSREIGPMLTKEQLFMDFCSMKEDIVEAMSRFSYA---------EVAGIHPLFGPTINGQNIIVCPGRGSVWLKWLENEFKKGGAVVTRMNPEIHDRNMAVIQGLTHMLTVCLGKLLQKLQMNPEEALLYSTPVFRINIDLIGRLLSQDNLYDDLIGGNPEVLKEFRSVLNEGEER............... 236
761 4.000e-38UniRef50_K2D5G2 Chorismate mutase/prephenate dehydrogenase n=2 Tax=root TaxID=1 RepID=K2D5G2_9ZZZZ  ali  12  18..........................................................................................................................ISDLGTRL--SNLQLARESDVIVISVPIDR-TVEVIESLVPFFRPDSLLMDLTSLKEGPVGAMLKSKSA----------VIGLHPMFNESTPGQTLITCPVRPKKWSGWVKETFEKGGFKLLRMTPRQHDEQMALVQSLIHFPEIVLGKTLATLHPDLKQVLDAASPSSRLKLMVAARLVQAPELYGNIQIQNPETFVQEAEALLRCVQQKDLKGFSRIFKAGQR 239
762 6.000e-38UniRef50_A0A0P7Z581 Chorismate mutase / prephenate dehydrogenase n=5 Tax=Cyanobacteria TaxID=1117 RepID=A0A0P7Z581_9CYAN  ali  13  113.......................................................................................................................................ELLQDIDLALVCVPIDR-TLEIIRQTAGYLSPTATLADITSIKGPMLETMLAAHPGP---------VVGLHPMFGPGVESQKVVICPGRDRPAWQWLVELMARDGGDLVESPPDEHDQMMVTVQAIRHFATFGLGVFLAQDGIEVGRSLELSSPIYRLGIDMVSRLFGQDELYADIMLANGEAIARLAQTFQVLAKQKDRKGLIEAMNAASE 324
763 7.000e-38UniRef50_A0A2H0S8P6 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=2 Tax=unclassified Candidatus Peregrinibacteria TaxID=1801912 R  ali  14  6.........................................................................................................IGIIGGNGKMGKLFAHFFKKNGIKILISDRELAQRSDIIILSVPIDK-TEQIITEIKPHIRPTSALMDLTSIKSAPIKAMLK----------AKCEVLGMHPMFGNSNPGQTIILCPTKKSSTSKWIEKLFEKNGVKIIKMTPKQHDKFMSIAQNLVHFSEIVFADSLRQQKMPLKQVMECASNSSQQKINSALTLITKDPLYANMIIENPNALSA------LKAHQKSVNELLKIVENKDK 241
764 8.000e-38UniRef50_A0A1W1X4I8 3-dehydroquinate synthase n=4 Tax=Desulfacinum TaxID=35836 RepID=A0A1W1X4I8_9DELT  ali  11  17.........................................................................................................VGIIGGLGAMGRVFYRFFASRGMPVSLSNQDLIDRSDVVLVSVPLHRA-VEILEELCPCFRPRQLVLDICSLKVEPMRALDRSAAW----------FVGLHPMYGPDFHGQTMIACRGRVPDAVDWLWSLFEGAGLKIHECTPEEHDRMMTVIQLIPHMATVVLGHCLRTLDVPVQESLRYTSPIYRLELDLIGRLFAQDPLYAAISMKNPEAFQSAFERSLALVRQGNWHEFIEDFRRTSD 265
765 9.000e-38UniRef50_A0A073A6E3 Prephenate and/or arogenate dehydrogenase n=25 Tax=Francisellaceae TaxID=34064 RepID=A0A073A6E3_9GAMM  ali  15  40...................................................................................................................................NNPKDKLANQDIVILSVPI-YLTEKIIKKVIPYLSQGTILADYTSIKQEPLDAMLKYYDGP---------VVGLHPIFGPTIKHQVIVVCDGRDQELYKFFIDDLAKIGFSIEKMTAKDHDQAMTFIQGIEHFSVYCLGMFLKHKGIDIQKMLKLASPVYKMELNIVGRLFSQPGLYADIIMSDESRQKAIAEFAEFVAEN............... 234
766 1.000e-37UniRef50_A8ZT67 Prephenate dehydrogenase n=2 Tax=Desulfococcus TaxID=896 RepID=A8ZT67_DESOH  ali  11  33.............................................................................................................................AGRKTEVTYEDLVRDCDVVILSMP-QKAAMAVAGRIGPAMREDQLLMDFCSQKAGIVAAMAGATRA---------DVIGTHPMFGPSTAGQNIILCPARSHNWLSWVERVFADGGAVVTRMEPEEHDRKMALAQSLKHFLTVSLARMLQTLDIRPDDAFLYATPIFRLNINLIGRLLAQDSLYADLVSGNPQAFLAAMEESRRAFFSGDEQKAADYLTEIRK 255
767 1.000e-37UniRef50_A0A1F6R7D5 Uncharacterized protein n=1 Tax=Candidatus Moranbacteria bacterium RIFCSPHIGHO2_02_FULL_40_12b TaxID=1801639 RepID=A0A1F6R7D5_9BA  ali  15  35.............................................................................................................................AGRKTELTPKELAKRADIVIVSVPVRE-TSSVIMNIRNLLKPSALLCDFTSVKEEPMEEMMKRKKG---------GVLGIHPLFGPSIEGQVIVFCKGKNNKWVSYLERLFKSNKAKIKYMKPKEHDRQMAMIQAMTHFVNITFAKVLQKQKMETKNI--FTTPVFRLQAMIMGRILGANPLYVDLEIKNKSFPKVLNDFMQEAERGEVLRGESEKLEK... 247
768 1.000e-37UniRef50_A0A1I4U9K4 Prephenate dehydrogenase n=1 Tax=Thermodesulforhabdus norvegica TaxID=39841 RepID=A0A1I4U9K4_9DELT  ali  9  50...............................................................................................................................VGTPVSSEEIFQQSDIVLFSVP-LHRTVEIIESYAPRFGKDQLVMDVSSLKVQPIKAMLKGVAS----------VVGLHPMFGGSVRGQTLVACPVRDREGWLVVKEQFLREGLKVVECSPEHHDRMMAVIQVLFHLCTMLKGRVIREMGIDIEETLRFTSPVYRLEISILGRMFAQNPLYAAISQLNPEIIDHLLEGLSLFRRKGALEKFVEEFRD... 266
769 3.000e-37UniRef50_B8FFQ7 Prephenate dehydrogenase n=4 Tax=Desulfatibacillum TaxID=218207 RepID=B8FFQ7_DESAA  ali  11  37..............................................................................................................................GRKTELTWQDLAEQCQVVIISLP-LDVSIDMARQVGPLMNKDQLLMDMCSMKHDICQAMKESTQA---------QVIGTHPLFGPGMAGQNVIVCPMGEGPWLPWLESQLEAKGAVVTITDGYTHDRNMAVVQALTHFMTISFGETLLQLGVDPKEIRPYATPIFRLKLGLLGRMFAQDELYRNLICKNPMA............................. 222
770 3.000e-37UniRef50_A0A1V5GW69 T-protein n=8 Tax=root TaxID=1 RepID=A0A1V5GW69_9DELT  ali  13  34............................................................................................................................................SDVLMVSVPIRDTIP-VIRDIAPFLSKEQILCDLTSLKTGPVTAMLASRAS----------VVGLHPMFGPTVPGQTIIATPARDDSALASLLSVFEREGARITFSTPQEHDRMMAVVQGLTHSVTLTVAETMRRLGVSPEATGPYRSPVYQIEMGLVGRLLSQDPLYADMLTENPY.............................. 204
771 5.000e-37UniRef50_A0A256Y008 Uncharacterized protein n=1 Tax=Candidatus Aenigmarchaeota archaeon ex4484_52 TaxID=2012504 RepID=A0A256Y008_9ARCH  ali  9  38..............................................................................................................................GRKTRLTNIDLAKKSDIVIVAVPI-HSTIDVIAEILPYLKDNALLMDITSLKINPINEMKK--------AKKTIGIVGLHPLFGPSIENQYIAVNEIRENKLWKKIKKLFLENKAQLIYIDSKEHDRKMALMQALLHFMNLCYTKTLFNNNLNIEG--KFSTPVFRLQSIIIGRILGQNPLYADLQMQNPDEILNSFVNVKKIIETKNKKKFVEEFNDLK. 256
772 5.000e-37UniRef50_A0A1G2PM91 Uncharacterized protein n=2 Tax=Candidatus Terrybacteria TaxID=1817920 RepID=A0A1G2PM91_TERXR  ali  13  47.....................................................................................................................................NRAVVEQANVVIFSVP-PRVVEGVIKALIAHSRPEQLWMDVTSIKVIPVSAMLTSRA----------EVVGLHPMRAPGLAGHVVAVCPERLDLWKSWTADFLAWTGARLKFCTPEEHDRKMAVVQGLVHAMQLTMAATIRSLDEDVHETLSFTSPVYRIALSLIGRILQQNDLYADIQMLNPH.............................. 222
773 5.000e-37UniRef50_F8C4P7 Prephenate dehydrogenase n=10 Tax=Thermodesulfobacteriaceae TaxID=188711 RepID=F8C4P7_THEGP  ali  12  31..........................................................................................................................VEVSDVNTTLTNIELVKRNKIILISVPI-EIFPEVVKEISSFVRETHWVIDICSLKNEPVKVMKKFL--------KKGEILATHPLFGPDLKGKTIAFYPVRGKEIVKWFKNLMSSEGLNLVKISPKKHDEIMALVQVINHFWLILLAKTIKDSGFNLKDLIYLSTPSFLRQLHILKRLAKQDPLYAKIQLENP--LGKKFRNL-LCRNCKDLAKAFNS-EKAEE 246
774 6.000e-37UniRef50_A0A2H6GRL8 T-protein n=2 Tax=unclassified Bacteria TaxID=2323 RepID=A0A2H6GRL8_9BACT  ali  12  43....................................................................................................................................TPKALAKKADIVIVSVPVTE-TAKVIKSIRGLLKPDALLCDLTSLKKDPMKEMMKRKQG---------GVLGMHPLFGPNMEGQIIVFCEGRKNKWVGFLKKMFELHNAKIVYIDPREHDKQMAMIQAMTHFVNIVFAKVLQKQKMEPQNV--FATPVFRLQAILMGRILGANPLYASFQTEN................................ 217
775 7.000e-37UniRef50_A0A256YSP8 Uncharacterized protein n=2 Tax=cellular organisms TaxID=131567 RepID=A0A256YSP8_9ARCH  ali  13  35..............................................................................................................................DIETEYSNKEIAEMSDIIIISVPISKVT-EVVKEIRNHIKKESLLTDTTSIKRYPLKEMKK----------AKCGVLGMHPLFGPDMKNKTIVFCRARDNIYVDFLKKLFRKNGANILEISPKEHDKQMAILQSLLHFTNISFSYFLYSKKF--KSNPNFLTPSFKLQSLVLGRILAQNPLYADIEMENPYFRKISEEYIKEITKFQKIIKDKKYEEFKNK 246
776 7.000e-37UniRef50_A0A1W9TSK6 Uncharacterized protein n=1 Tax=Desulfobacteraceae bacterium 4572_19 TaxID=1971626 RepID=A0A1W9TSK6_9DELT  ali  14  32..........................................................................................................................ISDLNTKLKNNDI--VQKCDVIILSTPI-DTAIKICKEIGPILKKNQLLMDVCSQKEDIVKSMLECGIS---------EVIGVHPMFGPFTEGQNIIVVPARVKHWSGWLEGVLEKENGVVTAMDAVDHDKHMALVQGLTHFLTVCMGRTMQKMNMKPEDTVSYSTPIFRLNCELLGRMFAQDDLYATLIGGNKYV-------------KDTLDLFQESMEEVNR 235
777 7.000e-37UniRef50_A0A1V5E7V4 T-protein n=1 Tax=Syntrophaceae bacterium PtaU1.Bin231 TaxID=1811718 RepID=A0A1V5E7V4_9DELT  ali  13  29.........................................................................................................................EVEVSGRSSGKSPEAMAASCDVVCVAVPISATVP-LIERVGPRMPEPSLLMDLTSLKVGPVAAMLRSSR---------CEVVGCHPLFGPSAAGQNVVLCPARSQRWLPRIRALFAEAGANVVETTAERHDAAMAVIQGMNHLHTVEMALLLEASGLDLGDLDAFSTPVFREKTEILARVLKNNPLYAEIICGNPA.............................. 218
778 7.000e-37UniRef50_H8IA37 Prephenate dehydrogenase n=1 Tax=Methanocella conradii (strain DSM 24694 / JCM 17849 / CGMCC 1.5162 / HZ254) TaxID=1041930 RepID=H8IA  ali  12  41..........................................................................................................................ARSLGVGLAS--PQDAGDFDVVVLSVP-MDVLEEVASDAAPRMRPGSLLMDLSSLKVKPLEAMLRH-------APPGVEVIGTHPLFGPDFSGRTIVLVPTRSVRWLPIIRPLFEEAGLNVLEATAERHDMNMAVVQGLTHFMYVAMGRALEKSQVNMEEASLFKTPVYGITKEMLGRVLSQSPLYALIQSSEHAAFIEACIELNSELEEGRLEDFIRDFKSA.. 262
779 2.000e-36UniRef50_Q0W4U2 Putative prephenate dehydrogenase n=3 Tax=Methanocella TaxID=570266 RepID=Q0W4U2_METAR  ali  13  42..........................................................................................................................AESLGAGVAS--VDYAGQFDVVVLSVPI-DAIEGIAAQVGPRMKPGSLLMDLSSLKTGPVEAMLK-------YAPESVEVIGAHPLFGPGLEGRTIVLVPTRSGRWLSVMRDVFETAGAAVEISTPGEHDRKMAIVQGLTHFLYISWGRAIQWMDVDLRDLEAYRTPVYGVTETMAGRVLAQNPLYALIQSGHDKAFIEACTELAAMIDAGDLETF......... 257
780 2.000e-36UniRef50_A0A1V4XTP6 T-protein n=4 Tax=Deltaproteobacteria TaxID=28221 RepID=A0A1V4XTP6_9DELT  ali  10  66....................................................................................................................................................PIG-VTQEVIRQVGPHMKKDSLLMDLTSLKAGPVRAMLASSPS---------EVIGLHPLFGPSVPGQNIAICPARGETWLPRVRGILEGRGAKLVETTPERHDEIMAVVQVLNHLDTIAMGLAIRRGGIDHETLEAFSTPLFRGKRDMIARVFSNMDLHAEIITANPHA............................. 228
781 3.000e-36UniRef50_UPI0003FE0E1B prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Desulforegula conservatrix TaxID=153026 RepID=UPI0003F  ali  14  32..........................................................................................................................ISSRRTELTS--KELALRSDVIFISTPV-EAALEIAKEIGPILREDQLLADFCSQKEAIVKCMVENTKA---------EVVGTHPMFGPTLKGQNVILCPGRGTRWLEWLEEIFGAEEAVLTRMDGKQHDTFMAVTQGLTHLMSVALARTLQRLDINADEAMKFATQVFRLKLDLIGRLFALDSLYNSLMGKNPY.............................. 218
782 4.000e-36UniRef50_A0LPT4 Prephenate dehydrogenase n=2 Tax=Syntrophobacter TaxID=29526 RepID=A0LPT4_SYNFM  ali  13  2.........................................................................................................................................LESSDIVLFSVP-LHRTEAIIRDLVPYAKPHQLLLDLSSLKVGPVREMLRSAS----------FVVGLHPMFGSTFRGQTIVACPARTPDWL-RLRSLLSAGGMEVKESTPEEHDRMMSIIQVLFHMTTMLTGRVMRRMGIDLAEVLEYASPGYRVELSQVGRLFAQSPLYSAIIQGNPGT------GEVLAQLREGLELYGGWFEKQE. 198
783 6.000e-36UniRef50_A0A2T4CVE3 T-protein n=5 Tax=Idiomarinaceae TaxID=267893 RepID=A0A2T4CVE3_9GAMM  ali  12  64.................................................................................AEALGLSPDLIEDVLRRIRESYQQVTIVGGAGALGQLFVRQFRSAGATVRILDRELVAKADLVLVSVPIAQ-TEAVIKQL-PELDADTILADVTSIKDKPLQAMLTKHAGP---------VVGLHPMFGPTLAKQLVVVTHGRGPEQYQWLLDSIVRWGAHIREVSSTEHDEAMGFVQVMRHLSTFVYGMHLAEEKADLQQLLDLSSPIYRLELMMVGRLFAQNELYADI-------ILSQPQNFAMMRRYNTFGRILDELEHADK 336
784 8.000e-36UniRef50_A0A090TFG4 Chorismate mutase I n=11 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A090TFG4_9VIBR  ali  12  1............................................................................................................................................................MIEKLG-NLPEDCILCDLTSVKSKPLNAMLNVHQGP---------VVGLHPMFGPDVPSQVIVYCDGRQEAEYQWLLEQFKIWGASLCQISAEQHDKGMTLIQALRHFTSFAYGRHLSQQNPDLDTLVKLSSPIYRLELAMVGRLFAQDPLYGDIIMSSDENIE------MIKCFHKQFGEALALLDSKDK 179
785 8.000e-36UniRef50_A0A1G5E5U7 Prephenate dehydrogenase n=1 Tax=Desulfoluna spongiiphila TaxID=419481 RepID=A0A1G5E5U7_9DELT  ali  15  28........................................................................................................................HRVLLADVDTTTTAEELTRRCDLIMIATP-MDVAPTVAEALGRRMSREQGLFDICSLKEEITAAMLDATS---------CEVVGTHPMFGPGLSGQNIILSQGRGERWLTFLEAEFSAGGARVSRMTPKDHDRSMALAQGLTHVVTIAMGRTLQKLGVTPDDALSYATPIFKLKNDLIGRLFAQDPLYAAMVGDNPYALSETAREMVDAERRGALDYMADI...... 252
786 9.000e-36UniRef50_A0A1G1YJE3 Uncharacterized protein n=2 Tax=Candidatus Buchananbacteria TaxID=1817903 RepID=A0A1G1YJE3_9BACT  ali  9  239....................................................................................................................................TNAQVVAASEVVIFSVPI-RCTPSIIHSVLPHTREDQLLMDVTSVKQPAVKKMLKGRA----------QVVGLHPMFRPEVSGQTVVVCPLTLAHWKTWVVNMLSATGATIKWSTPDEHDEYMTTVQVNPHLGNLTSALLITEAGISVTESLAFTSPFYRIMFSLMGRLVGQSPLYTDIVMENPETLILIERRMIKMIREKDRESFEQLFAQAKE 453
787 2.000e-35UniRef50_A0A0B3VR32 Prephenate dehydrogenase family protein n=4 Tax=Francisella tularensis TaxID=263 RepID=A0A0B3VR32_FRATU  ali  13  41....................................................................................................................................TPEQKLANQDIVILSVPI-YLTTEIIKRTIPYLSKGTILADYTSIKKEPLDCMLANYDGP---------VVGLHPIFGPTIENQVIVVCDGKQQDKYQYFIDDLARIGFSIEKMTAEAHDEAMTFIQGIEHFSVYCLGMFLKHKNIDIHKMLKLASPVYKMELNIVGRLFSQPGLYADIIMSDKQ.............................. 219
788 3.000e-35UniRef50_A0A2N2J5T6 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=2 Tax=unclassified Deltaproteobacteria (miscellaneous) TaxID=12  ali  11  2.....................................................................................................RMKKIKVGIVGGTKGMGHWFAVHVSGRKTKLQINDLARLSDVIVVAVPI-SATADVIRQVGPLLSTDQLLMDLTSLKKEPVKLMLANSRA---------EVIGCHPLFGPQLKGQNVILCPARGKKWLGWLKGVFKKNKLIVLESASGKHDKMMAIVQALNHLNTISLGMALAQTNITLAEINKFSTPIFRTKLDIIRKVFESPELYVDIITRNPE.............................. 220
789 3.000e-35UniRef50_A0A0G0MZX0 Prephenate dehydratase n=1 Tax=Candidatus Peregrinibacteria bacterium GW2011_GWF2_39_17 TaxID=1619067 RepID=A0A0G0MZX0_9BACT  ali  10  2........................................................................................................NVGIFGGNGRMGTAFASFFKNLGFQVFISNIEVAKLAEVLIVAVPIDK-TENVIKEINPYVRKKALLMDVTSIKEQPVKAMLKSKAA----------VIGMHPMFNETTFGQKILYSPARPGKWLPWFLDVFEKGGFKLIKISPKKHDQIMAFAQTLVHFTDFALAKTLSRLGPNLSELLSLASPASCLRVKIAARHLAQDALYGNIQFQNLQIFEEEVQELFRIVTKHDLGRFIAYFNQGKK 250
790 3.000e-35UniRef50_UPI00037E5364 bifunctional chorismate mutase/prephenate dehydrogenase n=1 Tax=Fangia hongkongensis TaxID=270495 RepID=UPI00037E5364  ali  18  12.......................................................................................................KNICIIGGYGAMGKMLKQFLSTLEYNITNDDSEALKDQDLIIISVPI-SVTKETISRCCQYIDKRTILADITSIKTDPLNWMLEFHKGPT---------LGLHPIFGPTIKDQVIIYCNGREPEAYNWFLKSLSSLQFTLKEMTAKSHDDAMTFIQGIEHFITFCIGGYLKQENADIEALLSMASPVYKMELNIIGRLFNQDPLYANIIASD................................ 225
791 4.000e-35UniRef50_Q5QUU3 T-protein n=23 Tax=Idiomarinaceae TaxID=267893 RepID=Q5QUU3_IDILO  ali  9  73.........................................................................DLIEDVIRRIIRESYRTQTAQAAATSTQLERPVFVFGGKGALGARLVSQLRQTGYSVITPDKDDLSQAQLVLMSVPVNK-TVELIKQLPP-LAEDCVLADVTSIKAAPLNAMLAQHSGP---------VVGLHPMFGPSVQNQLVVVTHGRQPERYQWLLDQFVNWGAHLHEVNADKHDDAMGWIQAMRHLSTFAYGVHLANERVDIKELLELSSPIYRMELMMIGRLFAQNELYADIIAANKASIRRYLQQFSAIIDNGKKSDFISLFDEVSQ 352
792 6.000e-35UniRef50_A0A2N2JSE2 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Deltaproteobacteria bacterium HGW-Deltaproteobacteria-11  ali  12  48............................................................................................................................................CDVVVVSVPIGK-TVGIIEAIGPLLHQESLLMDLTSLKTAPVEAMLKCSRS---------EVIGCHPLFGPSVRGRHIVLCPARTRRWLPWLRSVLQAAGARIVETTPEEHDRRMALVQGLNHLNSLLMGMVLSEAGVRPAELSPFSTPAFDEKMKLVKKILRHVRLSAEIMSLNPDIILDRYEEMKILVRKKDTDGLIALME.... 250
793 6.000e-35UniRef50_A0A2I7N5B4 Bifunctional chorismate mutase/prephenate dehydrogenase n=1 Tax=Neisseriaceae bacterium DSM 100970 TaxID=2052837 RepID=A0A2I7N5B4  ali  16  45.........................................................................................................................................LAKADWVIISVPI-HITSEIIVKVAKQINQNCVLSDFTSIKSSPLLVMLREHIGP---------VIGLHPMFGPSTHNQVIIACDGRYPEKTAWVTDLLLKLGFTVKHLDATKHDQAMSFIQGIEHFLTFSLGTFLHHKNQHPESLMELASPIYMAKLLLMGRIFDQDALYADIIMADNSRIE------LIREFSQWLNHWIDQLEQHNK 242
794 1.000e-34UniRef50_A0A2N1XIB0 Bifunctional chorismate mutase/prephenate dehydrogenase (Fragment) n=1 Tax=Gammaproteobacteria bacterium HGW-Gammaproteobacteria-  ali  11  54......................................................................................................................................AALVENAQLVLMAVPIDRTQEAI--QALPALPADYVLADVTSVKRAPLAAMLSCHPGP---------VIGLHPMFGPDIRSQVVVYCPGRDTAGAQWLLDQLGLWGAVLREESPERHDAAMVMIQAMRHFSTLVYGAFLRREGADLNDLLRLSSPIYRLELAMVGRLFAQNPLYADI.................................... 223
795 1.000e-34UniRef50_F0S2B6 Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase-related protein n=7 Tax=Desulfurobacterium TaxID=64159 R  ali  25  62........................................................................................................................KKVEDAGVKLTTDDIEAAKEAEVAILFTPFGGVTFKIAETILPYLVENAVICTTCTMSILVLNSYLQN--AIFLEGREDIGFSTMHPAAIPGTPQHELLRKPIVTEEQIEKLKKLATDTGKEAYLLPAELVSPVGDMGIVTTAIAFAGAIEYYKVSRDILKTKRSMTEFQIAQSLQVISSLVTKYGLEGLIKLLNVDAMKASLQSMILDKNEQPLVTASKLLEKIEE 296
796 1.000e-34UniRef50_E8Q5T7 T-protein n=6 Tax=Enterobacterales TaxID=91347 RepID=E8Q5T7_BLOVB  ali  13  70.........................................................................DLVEDVLRRIMRESYYKESKKGFKRLYSDCRPVVIIGGKGRMGQFFAKMLTLSGYQVKILDQDDWINAKVVFISVPIHLMTKVV--NTLPPLPDDCVIIDLSSIKTISLKTILNIHSGP---------VLGLHPMFSPDNENQAIICCEGRYPESYQWVLKQLQLWGAKLYYCTSMEHDKYMSFIQSLCHLITFADGYHLFKENVDLDKMISFSSPIFKLKLITIGRLFHQDPLYANI-------IMESHDNLILIKRYKRLGTMLMWLERNDK 337
797 2.000e-34UniRef50_X1QZI6 Uncharacterized protein (Fragment) n=1 Tax=marine sediment metagenome TaxID=412755 RepID=X1QZI6_9ZZZZ  ali  10  111.............................................................................................................................................ELAIISVPI-EVTVEVAGKLGPHLPVDCVLADVTSIKERPLNAMLEAYQGP---------VIGLHPLFGPTMDKQIIVVTPGRNLPSCRWLIDQFSAWGTIILQVNAQEHDEIMSIVQTVRHFATFAFGQFLCHKQIDLSRTIEFSSPIYRLELGMVGRLFAQDP......................................... 268
798 3.000e-34UniRef50_A0A0B8QQ89 Chorismate mutase I n=3 Tax=Vibrio TaxID=662 RepID=A0A0B8QQ89_9VIBR  ali  14  2....................................................................................................................................................PIN-LTESVIDKLS-NLPQDCILCDLTSIKQKPLEAMMKVHQGP---------VVGLHPMFGPDVPSQVIVHCEGRDAEQYQWLLDQFGIWGASLCPMDAEQHDNGMTLIQALRHFTSFAYGLHLSQENPDIDTLLKLSSPIYRLELAMVGRLFAQDLSYTVI.................................... 156
799 3.000e-34UniRef50_A0A2E5HIX2 Bifunctional chorismate mutase/prephenate dehydrogenase n=1 Tax=Myxococcales bacterium TaxID=2026763 RepID=A0A2E5HIX2_9DELT  ali  8  210..........................................................................................................................................................EEVAGRLAPWVREDALMCDINSLKSGICRVYEERCRG---------EALGLHPMFGPTLRRQKTVVCPVRPGPTATWMTRELERLGMEIITATPEAHDRMMAVVQVLVHFNTLVMGEALRRTGLSIHESLRFTSPIYRLELAFVGRLFTQDGLYAEIEMRNPYSAEASVEAFQALIEQGDREGFEEAFGELTR 403
800 3.000e-34UniRef50_A0A1V6GIQ6 T-protein n=2 Tax=unclassified Verrucomicrobia (miscellaneous) TaxID=417295 RepID=A0A1V6GIQ6_9BACT  ali  12  165.............................................................................................................................................DLCLLAVPI-EITPSIALQIGKYLPPACVLTDITSLKRKPLEAMLRGHAGP---------VVGLHPLFGPTMDKQIVVFSPGRSLSKCQWFLDQLTLWGNVLVETPASEHDEIMGIVQALRHFATFTFGQFLCSRGVPVLRTLELSSPIYRLELAMVGRLFAQDPLYAEI-------IFATPERQALLKDYESLQKNLSLVERGDK 358
801 4.000e-34UniRef50_E1QE65 Prephenate dehydrogenase n=1 Tax=Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14) TaxID=644282 RepID=E1QE65_  ali  14  47......................................................................................................................................RDLAQNCHVLVLAVPVGQMT-TVMAELGPLTRPDGLVVDLCSLKETPLQAMLAHARG---------QVVGCHPLFGPGLDGQTVFLCPGRGQSWLERLQNFLHTQNANVVSLTATEHDKLMAIVQSLRHILVAALGQTLANSDINLKAILPMAGPWFNHLAQLLQNQAAQPALYAHLATQNPQALRQAIDNITQAIQDNDENALIKYLD.... 255
802 4.000e-34UniRef50_UPI000410F96D prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Desulfatiglans anilini TaxID=90728 RepID=UPI000410F96D  ali  11  8.........................................................................................................VGIVGGNGRMGSWFKHFFEQQGLRVLTSPADLARRCDVVVLSVPIAATLP-VIRELAPLVRTEALLMDLTSVKAEPVHAMLAWGA---------CQVVGAHPLFGPEARALRMVLCPGRGEDGLGWLQTVLRAGGIQPCLMPPEDHDRRMGVIQGLLHFTTLVLARCLAGSGFAAEELEACATPNFQQAVGRIRGLLAQSDLFEGLLMANPDAYIQAAEQLREEIRGLDRVAFNRQFD.... 252
803 4.000e-34UniRef50_A0A1V4MAA9 Uncharacterized protein n=1 Tax=delta proteobacterium MLS_D TaxID=1775673 RepID=A0A1V4MAA9_9DELT  ali  10  59.........................................................................................................................RVHAAGRNSGMAVEEMARRCSVVIVSVPI-EATLSVIDRVGPLLSGDSLLMDLTSVKEAPVRAMLSSTGA---------EVMGCHPLFGPSVDDLSIVLCPARVDRWASWPSGIFAAAGIKIIETTPEEHDRVMAVVQGLNHLDTILLALTLGHCGIERSDLERFATPLFRSRLAALDRVMAGNHMYAEIICSNPRVAS------LIEEFEKILGELRGYIEKGD. 271
804 7.000e-34UniRef50_A0A1V4XNN0 T-protein n=9 Tax=Syntrophobacterales TaxID=213462 RepID=A0A1V4XNN0_9DELT  ali  9  57.........................................................................................................................................................TTEVIEQIGPLMAKDALLMDITSLKAEPVKDMLRCAE---------CDVIGCHPLFGPEVPSLEFVICPARSGRWLAWLRTLLKDNGARIVETSPEEHDRFMSIIQGLNHFNTMTFGLAMNAMETDIETLKPYMTPIFEEKIRIIKEVFSHNAMYSEILTRNPY.............................. 217
805 1.000e-33UniRef50_H3KBY7 Prephenate dehydrogenase n=2 Tax=Sutterella TaxID=40544 RepID=H3KBY7_9BURK  ali  12  399......................................................................................................................................REILAGAGIVVVSAPI-DVTIAVIKQLGPLLDPDTLLCDVTSVKRAPVEAMLKAHTGP---------VLGMHPMFGPDLARQVFVYVRARCPEASEELRRDLLSEDVSVVECSAADHDRSMSIIQALRHFTTYAYGVFLSKIRPDLRQILALSSPIYRLELEMVGRLFAQDPLYADIVLSNADIIRAYVESLADMVLRRDRDAFISRF..... 606
806 2.000e-33UniRef50_A0A0U2XX08 T-protein n=147 Tax=root TaxID=1 RepID=A0A0U2XX08_9GAMM  ali  11  72...........................................................................LVEDILRRMMREAYENQQSELACAAPQLSPVVIVGGAGAMGQLFARQLQRSGYEVRADQASILADARLVLLSVPINAL-EQVIQDLPP-LPDECILADITSVKQAPLQAMMKKHPGP---------VVGLHPMFGPDISHQTVVVCDGRGGEVYQGLLDQLQIWGCHLANMAAKKHDQAMQIIQVMRHLTTFVYGQFLARQCHTLEELRSCSSPIYQLELMMVGRLFAQSGLYTDIQFDEVEGLLASYQ....................... 323
807 2.000e-33UniRef50_A0A2S9RFE4 T-protein (Fragment) n=1 Tax=Haemophilus influenzae TaxID=727 RepID=A0A2S9RFE4_HAEIF  ali  12  2................................................................................................................................................IVSVPIN-LTLETIERLKPYLTENMLLADLTSVKREPLAKMLEVHSGA---------VLGLHPMFGADMAKQVVVRCDGRFPERYEWLLEQIQIWGAKIYQTNATEHDHNMTYIQALRHFSTFANGLHLSKQPVNLANLLALSSPIYRLELAMIGRLFAQDELYADI-------IMDKSENLAVIETLKQYDEALTFFENNDR 192
808 2.000e-33UniRef50_A0A0S8CAC3 Uncharacterized protein n=3 Tax=Chloroflexi TaxID=200795 RepID=A0A0S8CAC3_9CHLR  ali  15  17..................................................................................................ARHLLNEGNEVIISGRTESKIREAKKELGIEVVP-NVEAVKDAEVILLSVPI-DTFEDIVVELAPHIRSEQVVVDVTSVKSMPVDVMHRHL--------KTKKVLGTHPLFGPGVSGQNFVLTPTGSEERAEKARVYLETRGASVSLMTPEEHDDKMAVILGLSHFIAIVAGDTLLNSNKVL-QPTSLGGVTYKVLLTLVESVIENSELYAAIQMNLPELFQGKVAEWAEVVKNKDRDAFIQRMK.... 262
809 2.000e-33UniRef50_A0A0B3B8I9 Prephenate dehydrogenase n=1 Tax=Archaeon GW2011_AR21 TaxID=1579379 RepID=A0A0B3B8I9_ARCG8  ali  16  59.............................................................................................................................................DAVILAVPEKAAI-SLAGKIAKELKKGALLADFCSIKSRICPELEKI-------KRKDIEIASMHPMHGPRVKGFPIIFIKIRNGENFEKIKNAFQNANGRIVESDALEHDKTLAIVQGLTHFTQILSAKTIYDLGVDVERSLQFASPVYELYLDTIARVVTQNPMYAEIQLANPYKLLKAAKELLQTCKRNDLEGLEKEIFKTS. 266
810 3.000e-33UniRef50_A0A212TBX5 Chorismate mutase n=7 Tax=Kytococcus TaxID=57499 RepID=A0A212TBX5_9MICO  ali  14  46...............................................................................................................................AEVAARDAEVLAAADLVLVAVPIP-VTPEVIAGLPP-LRPDAVLADLTSVKGPALEAMLAAHAGP---------VAGLHPMFGPDVAGPVVVHSPGRGD--VHWLLERLTGWGLRVEPVAAAEHDRLMGLIQALRHTVTAAYGVNLRREGADLDTLLALSSPIYRTELMMVGRLFAQDGLYHDIITANLELLERFHQELITGLRAGDREGFVAEFEAVGE 262
811 3.000e-33UniRef50_A0A2P6LKZ2 TyrA n=1 Tax=Nephila clavipes TaxID=6915 RepID=A0A2P6LKZ2_NEPCL  ali  12  685......................................................................................................................................AQLCQDAALVLLAVPIT-LTEQVIAQL-PTLPAQCVLADLTSIKARPLQAMLAQHSGP---------VVGLHPMFGPDINNQVVVVCDGRQPEDYQWLLKQLVIWGAELTTKAADEHDSAMQLIQAMRHFSSLVYGVHLAEEQADLNELLALSSPIYRLELAMVGRLFAQNELYADI-------MLSSADVTALLQRQQRFTQLLGLLAAQDK 884
812 4.000e-33UniRef50_D5VT46 Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase-related protein n=25 Tax=Euryarchaeota TaxID=28890 RepID  ali  25  45.......................................................................................................DVILAEPNKNKLSEEQWEKVESANVKVTDNDLEAARHGEIHIFFTPFGK-SCDIIKNVIEKLPENSVICTTCTVNPLLLYY---ELEPILRLKRKDLGVSSFHPASVPGTEGETLTKKKLATDEQINKLVELCKSINKKPYVVPAELVSAVADMGVLVTALALSGILCFYYLGTRYIKAHKDLIEKQIINSLYTVASLVESSGVEGMAKALNPELVIRAAKSMLLVDKQKDLELALDLLSQLSE 292
813 4.000e-33UniRef50_A0A2E9G4G4 Uncharacterized protein n=2 Tax=Bacteria TaxID=2 RepID=A0A2E9G4G4_9RHOB  ali  13  44...................................................................................................................................SSNKELVENADVIFLAVPITYM-QAVLKEVFPYLNQ-KILIEVCSVKKFIIDDFNELQKENPDVQ---VEFHSFHPMFVSSLEGQVFLYCFNANNNGFDAFSKWLLADDANILNLEYIRHDKVMGVVQGLNHFNIFVSARALEQAGHNLGKIKDVSSPPYRIFLIFFSRYVLQDPLYADIQMYNPEVLKQEVDNLYNIILKKDKAAFIEYVENTR. 264
814 5.000e-33UniRef50_A0A101DPC2 5,10-methenyltetrahydromethanopterin hydrogenase (Fragment) n=1 Tax=Methanobacteriaceae archaeon 41_258 TaxID=1635284 RepID=A0A10  ali  83  1...MKVAILGAGCYRTHAATGITNFARACEVAEEVDKPEIAMTHSTITMAAELKELAGIDDIIVSDPVFDKQFTVIDDFDPEEVIEAHKEDP............................................................................................................................................................................................................................................................... 89
815 5.000e-33UniRef50_A0A1G1HDT5 Uncharacterized protein (Fragment) n=1 Tax=Nitrospirae bacterium RIFCSPLOWO2_02_42_7 TaxID=1801716 RepID=A0A1G1HDT5_9BACT  ali  13  2.....................................................................................................RAKKIGIIGSSRGFGKSVYGFFAKKGFPITGSNKEVVEDSDVVIFAVPIG-VTVQVIDEMLPYSREDQLWMDVTTYKVGAVNTMLKS----------SADVIGLHPLFGPTWRGQKIAVHMARVRAWSGWALDFLKATEARVELVDPAVHDFYMLGAQGLPQLLAFVQAKVILALGFDTKQLLKLATRFSRKSFGLIGRILQQKNLYADIQIEHPGAALREVQVMVDRKDQLGLISWIEELDK... 256
816 7.000e-33UniRef50_C0KGK1 Prephenate dehydrogenase (Fragment) n=6 Tax=Oscillatoriaceae TaxID=1892254 RepID=C0KGK1_9CYAN  ali  13  61.............................................................................................................GGTGKMGLFFADQLIDAGHRVKLDDWQDAENADLVMVCVP-TDQAVSVIEKAAPFLRQTTALTDIISIKAPILEAMLTHHSGP---------VIGLHPMFGPGTRSQNVVVCPGRKVSAFDWLLKLIERNGGKLRTSSATEHDRMMTTVQGIRHFMTFGLGVFLATEDVDVARSLELSSPLYRLAIATVSRFFAQSS------SLSLEIMIGSEQSRRILQR................ 276
817 9.000e-33UniRef50_A0A0G1GVP5 Prephenate dehydratase n=1 Tax=Candidatus Peregrinibacteria bacterium GW2011_GWF2_43_17 TaxID=1619068 RepID=A0A0G1GVP5_9BACT  ali  9  18..........................................................................................................................ISDINTKLTA--ADLVKQSDIIIISVPINK-TADVIKKIIPGLGASKLVMDFTSVKEMPIHEMMKSKAA----------VIGLHPMFNDTTPGQKILICPKRPKHWMPWVHEIFVGEGGFIHEMSESDHDKLMSIVQCMVHFAEFAFGKALQERGLKVEEILPFSSPASALKIEIASRLLSQDALYGNIQIASDDTFIECSKELANIVRRKDLQEFEKYFNEAAR 239
818 9.000e-33UniRef50_A0A257AHF2 Prephenate dehydrogenase n=1 Tax=Methanosarcinales archaeon ex4484_138 TaxID=1978123 RepID=A0A257AHF2_9EURY  ali  13  36.......................................................................................................................LDVAEKLGVPFADDINEAIGESDVVMISVPIN-ITESIIREIAPKMRPGSLLMDVTSIKKGPVDAME-------RYAPEGVECLGTHPMFGPSIPDIR----------------------GQTVILTPTRRCTRWLPVIEGI-----YSIAATLEAINFDVAKSRRFMSPVYEIMLDFVGRILAQNPLYAMIQT-NPDTFIGECRALSDLIKEGDIESFVERMKQAAR 234
819 9.000e-33UniRef50_A0A2H0HQT6 T-protein n=3 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A2H0HQT6_9GAMM  ali  12  140..........................................................................................................................................ANAGLVLLAVPIEH-TCAIIRAL-PALPADCVLADITSIKRAPLNAMLESHPGP---------VVGLHPMFGPDLAKQVVVVCHGRDPQRCQWLLEQFTVWGAVLREEQPERHDRAMVLIQAMRHFSSMVYGVFLQREGADLHELMRLSSPIYRLELAMVGRLFAQNPLYADI.................................... 305
820 1.000e-32UniRef50_A0A0W1AKI1 2-methylcitrate synthase n=1 Tax=Legionella waltersii TaxID=66969 RepID=A0A0W1AKI1_9GAMM  ali  12  68.........................................................................DFVIDIMRRILSESYLQAKKSPIYQVNPDVRKIVIVGANGKMGALFANQFKSSGYHVQELDKESVEEAGLVLICVPIEEF-LSVISELPP-LPKHCILADITSVKSKPMKAMLEAHQGPT---------VGLHPMFGPKVKHQLIVYCKGRETEKSDWLIKQLNIWGVRIEMCSPKQHDEMMAYVQTLNHLTFYVIGTFLINENINLDLLIRLGTPNSKVLLGLIKRFLDQSP......................................... 299
821 1.000e-32UniRef50_A0A1H0BIF4 Prephenate dehydrogenase n=1 Tax=Desulfonauticus submarinus TaxID=206665 RepID=A0A1H0BIF4_9DELT  ali  13  3....................................................................................................KSIKQITIFGSRGQMGRLFFKKAKNSGYLVLQDIEDALSRSDLILLCVPIKSLT-NVLKEISFYLHSSQILMDICSVKVLPLQMMEESFSGP---------VVGSHPLFGPDLKDRKIALCPGKSESEMELVYTFWQDLGFDPFIVSAVEHDKAMAYIQGLNFITNLTYFAY----KAGQKEIEQFITPSFQRRMDSAYKMLVKDRLFADLFEKNPYSSVRQFKSYLNLAAAGDLEVLAE....... 242
822 1.000e-32UniRef50_A0A0P7WZN7 Chorismate mutase / prephenate dehydrogenase n=15 Tax=root TaxID=1 RepID=A0A0P7WZN7_9BACT  ali  12  141....................................................................................................................................DLFRAV---DLVIVSVPIN-LTQAVIRKAAPFMPDYAVLADFTSNKKDALRAMVDAHPGP---------VVGLHPMHGPDLQNQLMIYSHGRDEDACTWVLNQFQLWGMRLLQVDPDRHDRVMHMVQGLRHFVALLHGSFMKDFDLKPEEILHFSSPIYRAELMMTGRIFAQDELYADIVFANEEQFMDHHSRLADMVRKGDKKAFVEEFENI.. 350
823 1.000e-32UniRef50_A0A1G9JGE4 Prephenate dehydrogenase n=1 Tax=Catalinimonas alkaloidigena TaxID=1075417 RepID=A0A1G9JGE4_9BACT  ali  12  44...................................................................................................................................TDNRELARHANVVILAVPIKAMIP-VLEEIYPEL-HGKVLIDVCSVKEFLVERVEQLREE---NPDQHTYYASIHPMFAPTMEQLETVL-PARFE---RFFRGLFSKDGARWYDVDYRMHDRLMGVVQGLNHFNVFVSAKALRKCGVALADIKNFASPPYRIFIVFFTRYVLQNPLYADIQMYNRHVFREEVDRLLTIIENQDRPAFTEYVNE... 263
824 2.000e-32UniRef50_E0UFY8 Chorismate mutase n=7 Tax=Cyanobacteria TaxID=1117 RepID=E0UFY8_CYAP2  ali  15  67................................................................................................PKTPVKSRRVTIIGGHGKMGRFFTVALQAAGHQVSSDWDKAITNAELVLICVNIEH-TLSVVRQAAPYLSASTIVADITSFKSMIVPSILELHSGP---------VLSLHPMFGPGVQSQNIIVCEGRHLEACQWFLDFMEKEGGKLTFCSLAEHDRMMTIVQVIRHFAMFGLGVFLAEENVNLEQSLNFASPLYRLQLDLIGRLFATDG......................................... 276
825 2.000e-32UniRef50_A0A2P5T1M5 T-protein n=1 Tax=Pantoea sp. SoEO TaxID=2044607 RepID=A0A2P5T1M5_9GAMM  ali  12  95..................................................................................................LHPKIKSIVIVGGNGQMGCLFKKMLISSGYNVKIIEKNDWHNADMVIISVPI-DVSKEIISKLSS-LPKDCILVDILSLKTIPLKAMLEVHSGP---------VLGLHPMFSPDLQNQLIIWCDGRYPKSYQWFLEQIKSWGMRMHRVNAIEHDYSMSFIQSLRYFKTFVYGLHLNEEKVNLDQLMDLSSPIHKLELSIVGRLFTQNPLYVDI-------MMSSKSNIALIKRYERFGRTISLLEQKDK 337
826 3.000e-32UniRef50_A0A2G6NS24 Uncharacterized protein n=1 Tax=Deltaproteobacteria bacterium TaxID=2026735 RepID=A0A2G6NS24_9DELT  ali  12  43..............................................................................................................................DVKTELTNVELACKSDIIILSTP-MDISPGIAVEIGGYISKDKLLMDFCSLKEEIVNVMLENT---------DCEVLGCHPVFGQYTKGHNIVFCPGRKGQWLDNLRKIFEDDNAVVSVISSKKHDEYMAVVQGLTHILTIAAGKFFMDSDIDINEILKFSTPVFRINAALTGRLFGLDSLYKDL.................................... 222
827 3.000e-32UniRef50_A0A2T2UZQ0 Bifunctional chorismate mutase/prephenate dehydrogenase n=1 Tax=Bacteroidetes bacterium QS_9_68_14 TaxID=1919111 RepID=A0A2T2UZQ0  ali  11  154.............................................................................................................................................DLALVAVPI-RVTEAVIRRLAEALSPQTVLADFTSTKSEPVATMLDAHDGP---------VLGLHPMHGPGLSRQLMVACPAREAEASAWLLEQCRLWGMRVEEAAPAEHDRVMHLVQGLRHFVALLHGSFMREAGLDPDDMLAFSSPVYRAELMMNGRIFAQDELYADI------VFASAERRRQLLRFFDQHERLAELVRANDK 347
828 3.000e-32UniRef50_UPI0009A1BD21 prephenate dehydrogenase/arogenate dehydrogenase family protein n=2 Tax=Alphaproteobacteria TaxID=28211 RepID=UPI0009A1BD21 :_  ali  18  128..............................................................................................................................GLNVATGSIEAAAAADIVMLAVPVQAMA-GVIARIAPVVRPGALVLDVASVKMLPARWMAEAL-------PPSVDIVATHPLFGPGLTGQPLVVCPVRGNRH-EKVAAFGRSLGLKVSITTAEEHDREMAYVQALTHLIGRTLVNI-----RIPDE--ELKTNSYQHLLELCGLIRDDTELFFAIQNLNPFAAEITQQ....................... 315
829 4.000e-32UniRef50_A0A2M7UNP9 Uncharacterized protein n=1 Tax=Candidatus Peregrinibacteria bacterium CG_4_10_14_0_2_um_filter_38_24 TaxID=1974774 RepID=A0A2M7U  ali  12  31..........................................................................................................................VSDIGTKL--SNKDLIKKSDIVVFSVPFEKSVQIMKKEISACTRKDQIVMDLSSLKKNQVEVMNKSKG----------NVIGLHPLFGPTTKDLNVVFCAGRCEKVFLEMKKLFEKLGFKIVVMTPEEHDKAMVLVQVIPHLKIFLAGELLKFSGINPEKFYDIGTPMYKIEMSFIGRIFAQDGLCTAIVANNPYSLIKFFGKTSKVYEKLILKNDIKSLSRR.. 248
830 6.000e-32UniRef50_A0A0P9DU88 Prephenate dehydrogenase n=6 Tax=cellular organisms TaxID=131567 RepID=A0A0P9DU88_9ARCH  ali  15  28.............................................................................................................VSSRSEGKLLKLR-EEFGIEIA-SNVNAVKKADRVLICVPIENF-EEVVKEIHSHVRSEQVVMDICSIKEIPVKIMHEYIKAGIT--------LGTHPVFGPGIKNQNFILTPTVEKEEVENFKSWLEERGANVFIMSPRRHDELMSVVLGLPHFLGLVVCDTLLDYGNLL-EMKKVAGASYKMLLTLAEAVAEETGFYASLQMTLPEILEKSGEWLDIVKRRDRLAFANKM...... 260
831 7.000e-32UniRef50_A0A0F9ZR04 Uncharacterized protein n=1 Tax=Candidatus Peregrinibacteria bacterium GW2011_GWC2_33_13 TaxID=1619061 RepID=A0A0F9ZR04_9BACT  ali  9  40.....................................................................................................................................NKDLVNNSDIIIISVNIDQTIP-VINEIEPYLNNQKLLMDLTSLKKEPVQAMLKTKAR----------ILSIHPMFNDTSSGQKVLISKVRCQKTVNRIKSFFHKYRVKTLDIDYKKHDDIMAIVQVLVHFAEISFTKTLEKIGIKVENLLAYSSPAYEIKIEMACRILAQDALYGNIQIRNPKLLMESSEELQKILENKDLNEFTKYFNKSQK 252
832 8.000e-32UniRef50_A0A256ZM05 Uncharacterized protein n=1 Tax=Candidatus Bathyarchaeota archaeon ex4484_218 TaxID=2012511 RepID=A0A256ZM05_9ARCH  ali  12  43..........................................................................................................................AKSLGVDYSLNYVEDVKNVGMVLVSTPI-EVTPKIILEVAKNLKKGAILFDVASIK-------HDVLPALKKAEKFGIHTLSLHPMFGPGAKSVKILTIPVTRKEVLKFVLKPFLDSGAKIVWVDAKTHDKMVALTLALPHFLNIIFGKTLSTSGFNIKKIKDFGGTTFNLQLILAESVVQEDPLYASIQTQNKEELFNHANNLKKIVLNKEKEKFSKFFLETRK 271
833 1.000e-31UniRef50_A0A101IZZ0 Prephenate dehydrogenase n=2 Tax=Methanomicrobiales TaxID=2191 RepID=A0A101IZZ0_9EURY  ali  12  3................................................................................................PSLRDDGRTIGIIGGTGSMGALFGQIFEDAGCTVASEYRGLAGRCSVVLVTVPI-SATEEVIRTVAPVLEKDQLITDLTSIKEKPVAAMLES----------GAQVIGLHPLFGPTIENQKLIMTPARDPETRLWLQGIFEEAGMQIHLSTPGAHDRAVAVTQGIIHLQSIAMAQMLRNMNCNLEELLPFATPNAHATFAFMARTLSQDNLYGGILQGNPSAYLKAVKEVGEMILQHDPEVFREEFDK... 257
834 1.000e-31UniRef50_A0A1B6Y7Z2 Bifunctional chorismate mutase/prephenate dehydrogenase n=17 Tax=Bacteria TaxID=2 RepID=A0A1B6Y7Z2_9BACT  ali  9  75............................................................................EDFLRMIMTSSRDKQSQDKFPIATAEPKHILYIGGEGGMGKLYKKITNQTGHKAYSELEEIAPKLDMVIVTVPI-KITEQVIERLKGRLSEKTILADFTSNKSSPIEKMLECHEGP---------VVGLHPMHGPDVQNQLMVVCPGRNAEEADWFVEQCELWGMRVIKADQNKHDHVMHMVQGLRHFVALLHGSFMEEYDLRPSDMLEYSSPIYRAEMMMTGRIFAQSELYADIVFANEEKFFEHHQKLAELVKQNDREGFIREFE.... 348
835 1.000e-31UniRef50_A8AAX2 Chorismate mutase n=2 Tax=Ignicoccus TaxID=54258 RepID=A8AAX2_IGNH4  ali  14  146.....................................................................................................................................PKEVAKEVEWLILAVP-PKAVPGLVKELAPLMRSGALLSDISSVKKTLVEEVLKVL-------PEYIEYISLHPLFGPEVEGETVVVVPVKSDYWVRLVQNIFVSMGFEVITSTPEEHDRAMAVTQVLHHFALVSLDEAAKKLSKEYGDYMRYATRSFKKTLETIQRLKELSEVIDEIQEMNEYAAHAREEFLKVASQMD.............. 341
836 1.000e-31UniRef50_A0A2A5CTC5 Bifunctional chorismate mutase/prephenate dehydrogenase n=2 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A2A5CTC5_9GAMM  ali  11  49................................................................................................PSAKQGNRKVVIVGGQGQLGQVFVNLFRISGYQVSIIEKNDWENSDLVLIAVPI-KVTNQIINKLS-NLSNECVLADITSIKQSPLKAMLTTHQGP---------VVGLHPMFGPDVANQTVIICHGRKSSEYQWLVEQLKIWQAVTYCISAEKHDQAMAMIQVMRHFSTVVYGYHLMEEETDLSEIIALSSPIYRLELAMVGRLFAQDGLYTDIIIDNAKSIKRRFEELLVLMESGDKQAFIKTFEKVS. 304
837 2.000e-31UniRef50_K9XMV5 Chorismate mutase n=7 Tax=Cyanobacteria TaxID=1117 RepID=K9XMV5_STAC7  ali  17  128......................................................................................................................................EELLNDRDLVLICVPI-EYTTEVIQKTVKYLSPNTALADLTSIKTPALKTMLEYHSGA---------VIGLHPMFGKVQSSQKVVVCSGRRDEEFQWLLKLIEADGGELIHSTAEEHDRMMVAVQAIRQFTTFSLGVFLAEQELDARRSLDFASPPYRLQLGMISRLLTQSA......................................... 291
838 3.000e-31UniRef50_A0A0P1ISL3 Arogenate dehydrogenase n=1 Tax=Thalassobius activus TaxID=1715691 RepID=A0A0P1ISL3_9RHOB  ali  18  49....................................................................................................................................SLIEAAE-ADVVILSVPVSEV-RGICEDIGDFLKPGAMVVDVGSVKISPIADMVECL-------PDHVQIVGTHPLFGPGIAGHNIALCPVRGSDWRMVRSFLSRVLKLRVITCTPEEHDKEAAMVQGLTHLIAKVITEMGPLPTRMTTASFELLSQAIEMVKDDPPTVLQ------AIEASNPFAAQVRAQ---FFERAERLKETFE....... 243
839 3.000e-31UniRef50_A0A244CUY0 T-protein n=1 Tax=Pseudoalteromonas ulvae TaxID=107327 RepID=A0A244CUY0_9GAMM  ali  10  73.........................................................................DLVEDILRRMMRESYQNQ-QSELACVAPDLSPAVIVGGQGAMGKLFAKQFQRSGIEVRILDKDILAGAKLVLISVPINAVS-DVVSALPP-LDPDCLLVDITSVKEKPLLSMLHAHTG---------EVLGLHPMFGPDIEHQTIVVCRGREGDKTQQLLAQLAVWGSQLVDMPADKHDEAMQIVQVMRHLTTFVYGQFLAKQPHSLEEIKSCSSPIYQLELMMVGRLFAQSPLYADIQFDNVAPLLASYQDTYQATLAK.............. 334
840 3.000e-31UniRef50_A0A133UNX2 Uncharacterized protein n=9 Tax=candidate division MSBL1 TaxID=215777 RepID=A0A133UNX2_9EURY  ali  14  13............................................................................................EWFAKFAKNRGWEVSISDIKKEKAR---KVAEDLNIEAAENNKKAVEKADTVLVSVPIKE-TPKVIREASNSLKRNSLLLDIASVKEKSVDAMEE--------IDVDSELVSIHPLFGPGAKNLEIVSIPVKAGNRYAELKKIFSNMEARVIEMEAVEHDRLMSITQSLTHYTLLTYFSALDSMK-GFEKAEKLKTPMFQNLLDLTKAFLHEDPLCGDIQTENRYSNMRSLDTGLKSKNTKPIEEIFEMAQDK.. 265
841 4.000e-31UniRef50_A0A2H0AR22 Uncharacterized protein n=4 Tax=Deltaproteobacteria TaxID=28221 RepID=A0A2H0AR22_9DELT  ali  10  45.........................................................................................................................QVVSIGKDTVLKARDAVPLCKVVVVSVPISDA-VEVISEVAPLVREETLLVDLTSIKSATMRAMLSLSKA---------QVAGVHPLFGPGEPSSRVALCPGRGKEGIQWIERFFKRKGFAVSMIDPETHDRMMGLIQGVNHFSTIVLALCMAESGFSLEDMTELSTASFMKRIERIHAMLAQPGLFQSLLMENKEAV............................ 236
842 5.000e-31UniRef50_A0A1F8PNA0 Uncharacterized protein n=2 Tax=Chloroflexi TaxID=200795 RepID=A0A1F8PNA0_9CHLR  ali  14  16..................................................................................................FARFLLKDGKEVVITGRNEEKLRSAQQLGVAVTTSNPEAVRGADYILVSVPVESF-EEVIGQVSSYIQTGQVVIDITSIKMSPIDIMHKYIKKGV--------VLGVHPLFGPGAGGQNFVLTPTSDAELAQKIKSYLEAREARVVLMRPQEHDEMMSLILGLSHFIAIVAADTLLSSGE-FRPMVTASSTTYKVLLTMIQSVLSEDPLYATLQMSLP............................... 230
843 8.000e-31UniRef50_UPI000D6D2643 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Sediminitomix flava TaxID=379075 RepID=UPI000D6D2643 :  ali  11  63...................................................................................................................................NSNIELVEAVDIVVLAVPIQAMT-STLEEIYPHL-SGKFLIEICSVKKFIVDKFLELKQA---YPEVDLSYYSIHPMFGPRIKNLTAFLFNYIYKEQIEFLKEFLLEDYAVIHDIDYLEHDKLMGLVQGLNHFNLFVSARTLHDFHDNIEMIKAVSSPAYRIFLVFFTRVLSNAELYADIQMYNEYVTE------VLKTFRKEVDNLLDLIENKDR 273
844 9.000e-31UniRef50_A0A0M9E805 Prephenate dehydrogenase n=2 Tax=Desulfobacteraceae TaxID=213119 RepID=A0A0M9E805_9DELT  ali  13  62.........................................................................................................................................................TIQIIKEIGPTVSEGRLLMDLTSIKQKPLESMLEHSKA---------EVVGVHPLFGPDAEGLRVAICPGRGRHGLKWVKDIFEKGKLQVSEMDPNEHDRLMGLIQGVNHFSTLGLAHCIRSSGFSIEDIEKCSTITFKNRLDRIYKLLDQPA------ELFGSLLIDNSESLNYIRLYRDLNDMIPIIENKD. 242
845 1.000e-30UniRef50_A0A2H9LVL2 Uncharacterized protein n=1 Tax=Candidatus Pacearchaeota archaeon CG06_land_8_20_14_3_00_35_12 TaxID=1974435 RepID=A0A2H9LVL2_9AR  ali  14  319..............................................................................................................................GRKTPLTYENCVKKSDVVIVNVPITN-TVEVIKKISPYFKKGQLIVDNCSIKTQAVKTMFEN-------VKKDIEVLGMHTIFGPKITDLVAFVHTEKSGEIARQFEDIFHKHGARIHETTCGEHDKQMAFHQNLEHFTKIALAELIRQEFEDPNTLENFTSPNSETSLITIGRILSSSPLLAEIQAHNTNA............................. 507
846 1.000e-30UniRef50_A0A239B6J2 Prephenate dehydrogenase n=1 Tax=Desulfovibrio mexicanus TaxID=147047 RepID=A0A239B6J2_9DELT  ali  16  5.....................................................................................................AIKTIAIVGARGQMGALFVRSFHKAGYAVTTLDRAAVAGADMVLISVPVT-ATREVAQALAPHMLPGAVLCDVCSVKVNPLSQMLEAYPGP---------VVGTHPLFGPVIPEPRVAVCPGRGQGAAEAVAGVFARAGFAPFDSTAEEHDRAMAVMQGLNFITTVAYLAAARQTPGI----EKYRVPSFERRLEAARKMLTQDELFQLIAEDNP............................... 221
847 2.000e-30UniRef50_UPI000CDB205B bifunctional chorismate mutase/prephenate dehydrogenase n=1 Tax=Escherichia coli TaxID=562 RepID=UPI000CDB205B  ali  14  23.........................................................................DLIEDVLRRVMRESYSSENDKGFKTLCPSLRPVVIVGGGGQMGRLFEKMLTLSGYQVRDRAADIVADAGMVIVSVPI-HVTEQVIGKLPP-LPKDCILVDLASVKNGPLQAMLAAHDGP---------VLGLHPMFGPDLAKQVVVWCDGRKPEAYQWFLEQIQVWGARLHRISAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQL................................................................ 231
848 2.000e-30UniRef50_A0A258H676 Uncharacterized protein n=2 Tax=Sphingomonadaceae TaxID=41297 RepID=A0A258H676_9SPHN  ali  16  37...........................................................................................................................DAARIGVVAGTLDAVAACDVVMLAVPVQAI-ERTLAAIAPQVRPGALVVDVASVKMLPARWMAEAL-------PESVDIVATHPLFGPGLAGQPLVVCPVRGERH-QRVAEFGRALGLKVSITSAEEHDREMAYVQALTHLIGRTLVNI-----RIPDE--ELKTDSYQHLLELCALIGDDSELFFAIQNLNPFA............................. 221
849 2.000e-30UniRef50_A0A0G1T7Z4 Prephenate dehydrogenase n=1 Tax=Parcubacteria group bacterium GW2011_GWA2_47_64 TaxID=1618845 RepID=A0A0G1T7Z4_9BACT  ali  11  239....................................................................................................................................SNIQVVERADVVIFSIPIED-TPAAIRSVLPYTREDRLLMDVTSVKGPTVDAMLESKS----------QVIGLHPMSAPEVDGQTVVACPLTLPHWKTWAVNMLAATGAKIKWSTPSAHDGYMLYVQGNPQFGNLASALLIAESEVSVSESLEFTSPFYGIMFALMGRLLNGDPLYASILMENPQTL------TMLERRVEIEQRLIELIRKKDR 442
850 7.000e-30UniRef50_A0A0F9P314 Uncharacterized protein n=4 Tax=marine sediment metagenome TaxID=412755 RepID=A0A0F9P314_9ZZZZ  ali  12  46............................................................................................................................ELAVNHELNLTKCITNADIVLVSIPI-HSTTKMIRKVAPLMKKNALIFDISSLKQNVCSALNEIKDAHP------INTLSLHPMFGPGIKLVLKIGGTEHYNKIVSKLLQLFKSDGLIITETTPETHDLRIALTLGVPHMINIVFLNLLKRTNIPLNELTNFTGTTFLLQKVFAESIIQREEMFGEIQIEN-------------SEFHKILDLFGELIKEYK. 255
851 8.000e-30UniRef50_UPI000D6CCD42 bifunctional chorismate mutase/prephenate dehydrogenase n=1 Tax=Pleionea mediterranea TaxID=523701 RepID=UPI000D6CCD42  ali  13  156.......................................................................................................................................QLLANKDLVLIAVP-MAETETTIEQLSG-LSDHTLLADITSVKHQPLQHMLKVHSGP---------VIGLHPMFGPGMARQLLLYTQGRQPEASDWLLQQFRQWGCYTESIDAEAHDTLMGTVQALRHFVTFVTGWQLMANGQSLDELLRVSSPIYRLELSLIGRLFAQPELYVDI.................................... 324
852 8.000e-30UniRef50_E0RS32 Arogenate dehydrogenase 2 n=15 Tax=Spirochaetes TaxID=203691 RepID=E0RS32_SPITD  ali  14  61................................................................................................................................HFTLTTYEGLLSCDVIVLCVSISAV-EEVARSLARDLPPSTLVMDTCSVKTYPL-------EVLSRTLPDGIDILGTHPMFGPGIAGLPIVLTPCRTEEQSSFWEETFREMGLSVHRMTAEEHDREAAYTQGITHFVGRVLGELHLED-----------SPIATVGYRKLLEIREQWQLFLDLQHYNPY.............................. 241
853 1.000e-29UniRef50_A0A1Q9N551 T-protein n=1 Tax=Candidatus Odinarchaeota archaeon LCB_4 TaxID=1841599 RepID=A0A1Q9N551_9ARCH  ali  14  32..............................................................................................................PNPDKYRSFINKIK---VEAYNDNRKAAGIADGVIVSVP-LDENVKVLKEILPFMKPNTFIIELASIKTPVEKFLTENLEYI---RERNISFLSVHPMFGPGAKSLKIILIPHPSNQNLESVKEYLKKQGANVIECSYLEHDRKIALTLALPHFLTMLFAAVVNNHNFNTD-IEKYAGTTFKILKLLADSLLESWRLYAHIQIDNEYTIE------ILESLKDYFNKLVKLIEDKN. 258
854 1.000e-29UniRef50_A0A2J1DY62 Prephenate dehydrogenase n=11 Tax=Dehalococcoidia TaxID=301297 RepID=A0A2J1DY62_9CHLR  ali  16  41..........................................................................................................................ATRLGVQAATRP-DMLGDMDCLIISVPI-DAFEDTLRELAPFTKPDQLVFDLCSVKERPVELMHQYLP--------HCRTLGTHPVFGPGLKGYNFILTPTTAPETAQGVKTWLEKQGGNVSLISPEEHDRLMSVVLGLAHFIAIVSADTL--LGQNLPGISSAGGTTFRL-LDTLTKLTEDPGLYASLQVNMPKLPKLEAD------FIKRATEWAELVKNGDK 253
855 2.000e-29UniRef50_A0A0G0SZF3 Prephenate dehydrogenase n=2 Tax=Parcubacteria group TaxID=1794811 RepID=A0A0G0SZF3_9BACT  ali  14  49...................................................................................................................................TDLTEM----DWVIPAVPISSL-EEVLKDIKPFLKKGSLLMDVCSVKVYPCRWLKKH-------APKDVEILGCHPMFGPGLKGLQIVVSPLRKEKRLKEVLTIFKKLGLNIIKATPEEHDKQGAVNLSLVHYIGRGLADSGFKDQKIKTA-----------GFDKLMGINENWQLFFDIQHFNPYS-------------KKIRQNYLKSLQKIEK 239
856 3.000e-29UniRef50_A0A0K9I550 Uncharacterized protein n=1 Tax=Desulfocarbo indianensis TaxID=1348163 RepID=A0A0K9I550_9DELT  ali  10  48.......................................................................................................................................ETAAQCLVLILAVPVPAF-EEVMRAVGPYTRRDGAVIDIASLKEAPLEIMLRYARG---------EVVASHPLFGPEPEGQTVFLCPGRGKVWASWWRSLWKRAGARVTEISPSRHDRLMAQVQTLRHLMVGSLGLVLKEMGFEPEEDLPLAGPWFASLWSLLENQAAQPGLYADLALANPEALSRAVSELGSKLEAHDQEGLAGLLDR... 255
857 4.000e-29UniRef50_Q8TWB3 N5,N10-methylenetetrahydromethanopterin dehydrogenase (H2-forming) n=1 Tax=Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 /  ali  25  17.................................................................................................RAAEAGHDVVLCDPSFDISEESMERLESAGVELVTDDTAGVEHGEIQILFTPFGH-TVKIARELLDDVREGAVLCTTCTCPPIALYHGLE---GELRTKREDVGVSSFHPAGIPGAETQDLILIELASEEQVERCVNLAEDMGYDVYVLDPELISSIGDMSVVLTVRIVQAICNYFSVAR-ICGAPIEMIEEQVEEVLSTMAYLVGRYGLDAF-DRMDGKLLLRSLRNMALTEDVERVVDFFE....... 263
858 7.000e-29UniRef50_M1WLY6 Prephenate dehydrogenase n=7 Tax=Desulfovibrionaceae TaxID=194924 RepID=M1WLY6_PSEP2  ali  12  7.......................................................................................................KKIAIVGESGQMGSVFRSAFTRLGCDVVPSDAEALDGCDLLILSVPVTAMA-GVLKQVKPYLTPPTILCDVGSVKILPIKSMLDAYDGP---------IVGTHPLFGPVTPRIAVVPGRKSDTDAATRVSALMESCGYSCFDSTAEDHDRAMAFIQGLNYTSTVAFL----AAARDVNGIENFITPSFNRRLDSARKMLTQDELFEIISEANP............................... 219
859 9.000e-29UniRef50_A0A239GG17 Cyclohexadieny/prephenate dehydrogenase n=4 Tax=Pseudomonas TaxID=286 RepID=A0A239GG17_9PSED  ali  16  44.........................................................................................................................EVEALGVPRCAEHLAALRDCDLVVVCVPTGAVAPVVLA-LAESMKPGAVLTDVGSTKQTVIDALSERL-------PAHVAFVPGHPMAGGEQSGCLLIPLATTPTPAIERVEGFWHALGAATCRVDARQHDRIAALTSHLPHLIAFSLMDTFGEQLPLDSQTGSFIGRSFFEQIRLASSDVT---VWTSIFENNSAALLSQTESFIAVLNQ............... 257
860 1.000e-28UniRef50_A0A154IDQ8 Uncharacterized protein n=1 Tax=Rhizobium leguminosarum TaxID=384 RepID=A0A154IDQ8_RHILE  ali  12  57.........................................................................................................................................VAKSDVVIIATPVNRLS-DVVSQLAPLLKKGALVMDVGSVKVLPAKIMAENL-------PSHVDIICTHPLFGPGLSGLKIALFSLRGTR-LAVVTRYLRCLGLVPLLTTAESHDRDMAVAQGLTHLIAKGLSQLEPLPSVLTTRSFDLIKSAAEMVRD------DSPKVFAAIQTQNPYAKAVRAKFLAILREFDEGVNTFD....... 249
861 2.000e-28UniRef50_A0A2E6REM1 Uncharacterized protein n=1 Tax=Xanthomonadales bacterium TaxID=2006849 RepID=A0A2E6REM1_9GAMM  ali  13  141..............................................................................................................................GVNVFSDWREAPLDVDLIVVAAPI-DASRRIIEELA-LLRPAGLLFDVASIKAPLVGALRRAAEAGLK-------ICSVHPMFGPDTRGHHVLLADCGNAGAVRQARALFDETMAALVEVSLDEHDRLMAWVLGLSHALNVAFGAALADSDVGADQLAAISSTTFQRQLDIATDVAAENPLYFEIQRLNPYALRRSLETLEASVLEGDSKSFVGLMQR... 359
862 2.000e-28UniRef50_A0A147JT58 Uncharacterized protein n=1 Tax=Hadesarchaea archaeon YNP_45 TaxID=1776334 RepID=A0A147JT58_9EURY  ali  11  57.............................................................................................................................................DLIFVAVPIAR-TPGVLLRLAKVAPRGALLVDVASVKGEVVKSMEKIKE--------DVELVSIHPLFGPGLRNKDVVVIPVRPGARYQEFRKILERSGARITEMSADLHDQAMAVIQCLSHFVLLAYLQTLRSL-DGVKLSRGLRTPIFSLAELAKAAAAGRPELYGELQRQNKYS............................. 227
863 2.000e-28UniRef50_R9T7Y9 Uncharacterized protein n=4 Tax=Methanomassiliicoccales TaxID=1235850 RepID=R9T7Y9_METII  ali  13  125.......................................................................................................................YDTTENIKYPCEKDLKQGVLEAEVVIIAVPI-SYTPMILEEVLSY-NTSALIFDVSSVKTPSAE--------ILKKGGKIAEVCSVHPMFGPETNSINVVICNCGSYSAVDKAEELFD--GANITKTDLDEHDKLMAYVLGLSHATNIAFFETLNRSGKSYSELSRVASTTFKDQVETSHNVVSDNALYYEIQNLNPYSLVDSVNTIKDAARKNNKDAFTKMMNEGKE 350
864 2.000e-28UniRef50_A0A1X6ZWJ7 Prephenate dehydrogenase n=7 Tax=Rhodobacteraceae TaxID=31989 RepID=A0A1X6ZWJ7_9RHOB  ali  13  46........................................................................................................................EDASKLGVSIAS--LGQVAKCDVIVVASPVSSF-ESVVRSIAPICRPGAIIVDVGSVKVQPSEIM-------DRFLPEYVSIVATHPLFGPGIRGLKVAVCPIRGHHHTHVAAFLRKHLGLHVIVTTPDQHDRDAATVQGITHLIAKVLLNMGPLPSRMTTKSFDLISEAISMVQHDAPEVFE------AIESANPYAKEVRQRFFSMAFE---LNSFLEDSERHD. 257
865 3.000e-28UniRef50_A0A1S7SDC5 Prephenate dehydrogenase n=1 Tax=Agrobacterium tumefaciens str. Kerr 14 TaxID=1183424 RepID=A0A1S7SDC5_RHIRD  ali  14  44...............................................................................................................................FDVVAADIRTVARCDAVVLAVPVNAISAAVAD-IKPYLQPGTIVFDVGSVKATPAMIMQNEL-------PPYVDIIGTHPLFGPGITGLKIALCPIRSSQFRRVAAFLRRSFGLKVVVVTPEEHDIETAITQGLTHLIGRVLIDM-----EPLPDRLRTASFDLLMRAADMVR-YDSNAVFMAIQRTNPYSAASRARFIATATALDSLVG.......... 244
866 3.000e-28UniRef50_UPI00040B7557 3-hydroxyacyl-CoA dehydrogenase family protein n=1 Tax=Desulforegula conservatrix TaxID=153026 RepID=UPI00040B7557  ali  17  14........................................................AGDMGHGIAEVALIAGYKVF-------LRDVKKEYVDKGVSRIHESLEKLVSKGKVAPD---HYEKIKNELLVSCVDLEEAVKEADLVIEAIPIMDLKKETFRIVDNAAPSHAILANTSTMSISEIASATKRPE-------KFVGLHYFNPAII--MKLVEVIKGDKTSEETMQVCYDFVLKNKKIPVRVHKDVPGFIVNRVQAPASILLNSILDKGEAAPDEVDAVMR.............................................................. 225
867 3.000e-28UniRef50_A0A1G1XNI2 Uncharacterized protein n=2 Tax=Parcubacteria group TaxID=1794811 RepID=A0A1G1XNI2_9BACT  ali  13  31......................................................................................................................SDKLVEAKKMGVVWSSLEQVCQCDWVIVAVAI-SATEEMIKKIAPLLKKRNLVMDVCSVKVLPAQWLEK-------YISQDNEIMATHPMFGPGTKDLQWVLCPLRSASTLDKVKEILNKLGVKIIETTPEEHDKQVAISLSLVHFIGRGLEDFGIEPQEI--------STMGFERLLKVNETVTNDSFRLFLDMQN---FNPYAKEMR--------ERFIESLDKVN. 237
868 3.000e-28UniRef50_A0A212Q615 Prephenate dehydrogenase n=1 Tax=Arboriscoccus pini TaxID=1963835 RepID=A0A212Q615_9PROT  ali  12  44..............................................................................................................................NVEIAATL-ETACTADIVVLAVPVQQLDELTVA-IAPHLRPGAIILDVASVKLKPAAILA-------RNLPANVDIVCTHPLFGPGIAGLNIAVCPLRGQSYACVVAFLRERLGLKVIETTAERHDRELAYVQGLTHLIAKILVQIDVS---DIKQTTRTWELL-MQSVEIVR--YDSEELFQAIESENPYVGEAKTRFFDAARALE.............. 240
869 3.000e-28UniRef50_A0A0F7CTL8 Prephenate and/or arogenate dehydrogenase n=8 Tax=root TaxID=1 RepID=A0A0F7CTL8_9CHLR  ali  11  28............................................................................................................TIVGRDKDKLAAASVE-LGVS-SSDNTGKAGEADVVVISVPVDSF-EAVCHNLAPHLNSGQTVFDLTSVKVKPVDIMHRYFT--------GIKVLGSHPVFGPGLKGQNFILTPTDDKATAFKVSDWLSTRGARVRTTTPEEHDRLMSISLGLAHFIAIVTADALVSLDR-LDEMNGAGGITYKALLTLVESVLSEDPLYASLQLNLPSLFSDKARDWATLVREGRRDEFVNRMSNLK. 265
870 3.000e-28UniRef50_T0Y2G8 3-hydroxybutyryl-CoA dehydrogenase (Fragment) n=1 Tax=mine drainage metagenome TaxID=410659 RepID=T0Y2G8_9ZZZZ  ali  17  29..........................................................................VVIEDAYSEALDKSEKTIVDSLSRLVKS-------------GKISASDSENIRVGFSSDLGEAVSDSDIIIEAVPIPDLKRKIFADVEKVAKPDSVLTNTSNIRISEIAKDLKNPERL-------VGMHFFNPPVI--MKLVEVIKGEHTNDEAFETIYNLVKKIGKTPIKVLKDTAGFVVNRISAPESLFFCMLLQTGVDSPEAVDTPMGPYELMDYVGIDTVVHSLE............................................ 246
871 4.000e-28UniRef50_A0A1V5WHK7 T-protein n=3 Tax=Spirochaetes TaxID=203691 RepID=A0A1V5WHK7_9SPIR  ali  15  40..................................................................................................................................TLVDLEELCTLPVVFLCVP-MRTVPDMLDRIAPLLAPGTLVVDTCSVKLEPVRWMTEKL-------PETVDIMATHPMFGPELTGLPLMMYPVRMQQAVDEWAHFFRSHGIMVVEITPDEHDRQAAMSQALTHVLGKTLNNMGIEETPI-------GTLWYRKLLAICKQVKDSPELFNDMQTINPYA............................. 219
872 4.000e-28UniRef50_Q3Z995 Prephenate dehydrogenase n=7 Tax=Dehalococcoides TaxID=61434 RepID=Q3Z995_DEHM1  ali  15  59.............................................................................................................................................DCLVISVPI-DAFEDTLKEIAPFTKPEQMVFDLCSVKERPVELMHQYLP--------HCRTLGTHPVFGPGLKGYNFILTPTTGAETAEKVKIWLEKHGSTVSLISPEEHDRLMSVVLGLAHFIAIVSADTL--LGQNLPGIAGAGGTTFRL-LDTLTKLTEDPNLYASLQVNMPKLPGLEAD------FIKRATDWAELVKNGDK 253
873 5.000e-28UniRef50_A0A1E7GXC2 Uncharacterized protein n=2 Tax=unclassified Desulfobacterales TaxID=1403365 RepID=A0A1E7GXC2_9DELT  ali  9  57.........................................................................................................................................................TNEVIRKIGPFIDPDSLLMDMTSIKVSPVGEMLKAFPG---------EVVGTHPLFGPGLSGQIVVITPARGEKGLLWLTDTYKRNNVKVTLATPEEHDRFMALTQCVRTLNTMVLSKLIMDNHLDPKTVLEYSTPIFKAEMWWVGRLFSQDPLYAGIQMNNNNDYLAAGKELVDIITRKNKRKFSEFFKE... 248
874 6.000e-28UniRef50_A0A2A5FC02 Prephenate dehydrogenase (Fragment) n=1 Tax=Zetaproteobacteria bacterium TaxID=2026807 RepID=A0A2A5FC02_9PROT  ali  16  28........................................................................................................GVVKRITGVGRSPQNLHDAIRLGVDASDNIQQAVQDADMVLLAVPVAACA-QVFKDIADALPEHAIITDAGSTKQSVIKDAQKSGLDMSR-------FVPAHPIAGTEHSGHRCILTPETSAESLAKVREMWKYTGANIEIMDAKQHDDIMASISHLPHLTAFSLINALHDDDV..................................................................... 208
875 6.000e-28UniRef50_D8EW30 Prephenate dehydrogenase n=15 Tax=root TaxID=1 RepID=D8EW30_9DELT  ali  12  30......................................................................................................................SDKTKEIIGIGAEPATLEEVCRQKVVILSVPISHM-QETLERIASLLRPDTMVIDVCSVKVYPVAWMKELL-------PPSVPLLGTHPMFGPDSADRKIVLSRVRDDERYQKVKKYLLGKGLNVIEATPEEHDRQIAVSLALTHFIGRGLDEFGAKLIIDTEGYKRLLHILGVVNHDT-------WQLFKDMYQYNPYARENRLAFMAALKRLE.............. 236
876 7.000e-28UniRef50_W4L796 Uncharacterized protein n=3 Tax=Candidatus Entotheonella TaxID=93171 RepID=W4L796_9BACT  ali  14  315..............................................................................................................................GRRTPLTYEQCIAQSDAVIINVPIKN-TVDTIYQVGKWFRPGQLIADNTSIKTQPVTAMLE-------AVPQGVEVLGMHTVFGPSLHGQNVVFTTHASGELSREFENIFYKYGAKITYTNPETHDRQMAFHQNLEHFTKLVLAHVLRGQFGDPFEMDSYSSPNSRTSLVTMGRILADPDLYSEIQAYNLQAYLEAAQQLGQALIAGDVETF......... 529
877 7.000e-28UniRef50_B1ZMW9 Prephenate dehydrogenase n=12 Tax=root TaxID=1 RepID=B1ZMW9_OPITP  ali  16  53.................................................................................................................................VTESAEAAVAGADLVVVAAPVDRIIP-LVQQVAPHLGAGAIVTDVGSVKGEIARQGHAALG-------DGAHFVGSHPMAGSEKTGWEVTPLPESNPAAVAKVVAFWRDLGGEPVTVPPDQHDEIVAHISHLPQIVASSLCAMLA......................................................................... 202
878 9.000e-28UniRef50_A0A0U5EXH2 Prephenate dehydrogenase n=26 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A0U5EXH2_9PROT  ali  15  47.......................................................................................................................EDTAQTLGVRLT--DLTTVAHCRIIILAIPVQAMA-DVLTHIAPLLRPDALVLDVGSVKVKPTELML-------RLLPPTVGIIGTHPLFGPTTTGLKIVLCPVRGP--YHRLAAFLRKLGLRVLICTPEKHDQDMAVTQALTHWLAQSLKTLETRSFDLMRDAMKMVEKDAPQVFETIECL.............................................. 229
879 9.000e-28UniRef50_B7KAH4 Prephenate dehydrogenase n=1 Tax=Cyanothece sp. (strain PCC 7424) TaxID=65393 RepID=B7KAH4_CYAP7  ali  12  48..........................................................................................................................IDNVRYEYDLDNIEDFKEFDLVILALPETAA-LTVLQDLKKWLNSDTLVVDTLSVKSTICSKVE--------SLALDVEYLSINPMFAPGFSNQTVVVVPLQTGDKTSIFLSLLRNWGATVKELTANEHDRATAQLQSLTHSTIMAFGLALIKGGYDIKQLLSIAPPPHKVMLSLIARIIGSPDVYREIQISNPYASENLADSVNLIDNQGSQADFADLFDKFE. 272
880 1.000e-27UniRef50_K2BYK7 Arogenate dehydrogenase 2 n=2 Tax=groundwater metagenome TaxID=717931 RepID=K2BYK7_9ZZZZ  ali  15  31..........................................................................................................................................AGCDLVIFAVPNRNL-EQAIAQWKPLIPDAAIIMDVGSVKTKPCQILQKQFSK---------NIVGTHPLYGPDSQGHKVVLCRLKDDESYRRVKDLFTSRGVTVYECSPEEHDQMMAKTQALVHFIGRALTGL---------EPQDIATPDYANLLKMMEKVTDTWELFYDMQTLNPYA---EPIRQNFIKKITQLDQDI........ 216
881 1.000e-27UniRef50_I6GYI5 T-protein (Fragment) n=1 Tax=Shigella flexneri 1235-66 TaxID=766154 RepID=I6GYI5_SHIFL  ali  16  37......................................................................................................................................ADIVADAGMVIVSVPI-HVTEQVIGKLPP-LPKDCILVDLASVKNGPLQAMLAAHDGP---------VLGLHPMFGPDLAKQVVVWCDGRKPEAYQWFLEQIQVWGARLHRISAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLAL............................................................. 180
882 1.000e-27UniRef50_A0A1G1JUA7 Uncharacterized protein n=1 Tax=Omnitrophica bacterium RIFCSPHIGHO2_02_FULL_51_18 TaxID=1801823 RepID=A0A1G1JUA7_9BACT  ali  14  23..............................................................................................GLAVKKRKLAKFVAGVVRRRETAIRVIEKKAVDM-ATLDLAEGVQGADLVILCAPVSTIIRQI-PLIKPYLKKNAIVIDVGSSKRRIESAARKHLKRNT--------FVGCHPMAGSACLGVEHADAELFDGAQCHRVHRLWKAMGAHPILLDAKLHDAWVARASCLPHLLAFSLFQKESFGRFSLTRLKAL-----NPSIKELARLAHSDALWSDIFMSNPDTIKA------LYAFEKSLGRLKKILHSKK. 260
883 2.000e-27UniRef50_A0A1F6K655 Uncharacterized protein n=1 Tax=Candidatus Levybacteria bacterium RIFCSPLOWO2_01_FULL_42_15 TaxID=1798626 RepID=A0A1F6K655_9BACT  ali  13  36.............................................................................................................................AGRKTPLTPKQLCRRADIVIISVP-TRVAPKVIEETIPLLKTGTLLIDFSSVKEKTMAVIQKRNN----------DALGIHPLFGPNVPGQTIIFCPTGRNRWTSYLQDFFERNGVSVIRISAREHDKLMTFVQDVIHFYNIAIGLSLGRQIKMIR--RGISTPVFRMQLEVLKRVFLSPA......................................... 206
884 2.000e-27UniRef50_A0A0Q8R656 Uncharacterized protein n=2 Tax=Sphingomonadaceae TaxID=41297 RepID=A0A0Q8R656_9SPHN  ali  11  60..............................................................................................................................................IVVLAVPVQAI-EEVLRAIAPHLRASALVVDVCSVKRKPLAAMA-------RLLPSHCEILGTHPLFGPGLAGSGIALVPVRGRQWRRVAAFLEKALHLDVIVTTAERHDRDMAYVQGLTHMLARVVGQMRLPTTPLTTR-------TYDHMLSMVG-LVGQDALFEAIMAENPYSAAVYDEFVGQFTKLRDLVNGFDII..... 250
885 2.000e-27UniRef50_A0A2A4UZP4 Cyclohexadienyl dehydrogenase (Fragment) n=1 Tax=Alphaproteobacteria bacterium TaxID=1913988 RepID=A0A2A4UZP4_9PROT  ali  18  4................................................................................FEQITIIGMGLIGSSIARAVRE-NNVADRLTGCDSNEAHCATALRLKLDMGTDPAKAVKNSDLVILATPVGTY-GDIGRIICPEMKPGAILTDVGSVKASVAKSL-------SPFMREDCHLIPGHPVAGTEQSGPDCILTPDVDPHRLKKLEKFWQALGSKIEYMTPEHHDMVLAITSHLPHLIAYNIVGTAR......................................................................... 203
886 2.000e-27UniRef50_A0A1G3P036 Uncharacterized protein n=1 Tax=Spirochaetes bacterium GWF1_31_7 TaxID=1802187 RepID=A0A1G3P036_9SPIR  ali  13  40.................................................................................................................................IVKTDLETALGQDIVILSLPVQYI-ENFLKSNCCFFKKGAIVLDICSVKLKPVSLMKQYL-------PKDVNFIGTHPLFGPGFSGQKIVLTEVENKELYEKVKNFLKDLQLEIIEMTSSDHDKEMARVQALNHFIVRALKKLDLQ-------PSLVSTPAYNKLFDLYETLYDSDDLFYTIQRENADAMRRNFINVLQDIEGDILNE.......... 242
887 2.000e-27UniRef50_B4R843 Cyclohexadienyl dehydrogenase n=8 Tax=Alphaproteobacteria TaxID=28211 RepID=B4R843_PHEZH  ali  16  68..........................................................................................................................................................REVFAAIAPHVKPGALVVDVGSVKVLPARWMAELL-------PAHADLVATHPLFGPGLPGLRFVVCPIRGDR-YERVAALGRELGLSVTITTPEEHDEEMAYVQALTHLIGRSLVN--------LGIPERLATQSYQHLLELCGLIADTFELFKAIQTQNPYA............................. 223
888 2.000e-27UniRef50_A0A1G3LDQ3 Uncharacterized protein n=1 Tax=Spirochaetes bacterium GWB1_27_13 TaxID=1802173 RepID=A0A1G3LDQ3_9SPIR  ali  16  44.................................................................................................................................FFTTLEECVKK-DIIILAIPV-QFIENTLLKIQNIINKNALVIDVCSVKIKPIELMKKYL-------PETIEIIGTHPLFGPGIEGLNIVLSDVRGTK-FECVKSFIEKLKLNVYIKTPEEHDKEMAMVQALTHFVGRGLTRFGVKDSILKTKSFDCLLGVYNILH------YETDELFYTIQKENPFAKEIRKKFLNILIDIKDLDN.......... 242
889 2.000e-27UniRef50_UPI000B9BB4EA prephenate dehydrogenase/arogenate dehydrogenase family protein n=2 Tax=Rhodococcus TaxID=1661425 RepID=UPI000B9BB4EA  ali  14  51..................................................................................................................................SDELREVLESADVVVLAVPE-DIAVAALPVITFILRPGALLAETLSVKTVLIPHLREHP---------DIEIIGINPLFAPDLRGRSIAVVEKRSGPRSARLLHLLTERGARLLFTTAEEHDRATATTQVLTHAAVLSYGVALARSGCEMTTLSDFATPPSTMLTAMLARMMENSPVYWDIQFRNPHALAQSLRRIADAVESEDRAQFAEYL..... 261
890 2.000e-27UniRef50_A0A2H5W1D7 T-protein n=2 Tax=unclassified Bacteria (miscellaneous) TaxID=49928 RepID=A0A2H5W1D7_9BACT  ali  11  42..........................................................................................................................ARELDVELVS--LEAACAADALFFAVPISEF-ESAIREARAHLGPGRLILDTCSVKVHPIEVM-------RRELPPWVEALGTHPLFGPGLQGLRIVFCPVRSATTLQFWRAFWQRRGVQVIEMSPDEHDRRAAYSQGITHFVGRVLGELPLESGEITTRGFEAIRGVIEQTTH------DTWQLFHDLQHYNPY.............................. 226
891 3.000e-27UniRef50_A0A2G6I2Z9 Prephenate dehydrogenase n=3 Tax=Spirochaetes TaxID=203691 RepID=A0A2G6I2Z9_9SPIR  ali  11  45......................................................................................................................................EKEVLQADVLVLCVAISSL-EEVLRRIAGQLRPNTLVMDTCSVKMYPVRLMKEIL-------PPEVEILATHPMFGPGLKDLPLVFSPVRDESAAAWQERFCK-MGLSVLPLSPEEHDREASITQGITHFIGRVLGEL------ELNES-NMATSGYRSLLDIVRQTCNDWSLFVDLQKYNPYTVMRRDVHQAITVMLERFDS-IEAINNGRK 249
892 3.000e-27UniRef50_A0A149TRJ8 Prephenate dehydrogenase n=6 Tax=cellular organisms TaxID=131567 RepID=A0A149TRJ8_9PROT  ali  18  47.......................................................................................................................EDTAQALGVQLT--DLRAVARCRIIILAVPVQAMA-DALERIAPLVRPDALVLDVGSVKVKPVEIMVSLL-------PSTVSIIGTHPLFGPTTAGLKIVLCPARGP--YHTVAAFLRKLRLNVIICTPEYHDQNMAVTQALTHWLAQGLKTLEPFSPHLTTRSFDL--------LRDAMKMVEKDAVFEAIECLNPYA............................. 233
893 3.000e-27UniRef50_A0A2V9MFV2 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Acidobacteria bacterium TaxID=1978231 RepID=A0A2V9MFV2_9B  ali  16  39.................................................................................................................................VTVTSFEEVARKPFLLLCVPISEI-QSVCRKLRPLLKKGQLVLDTCSVKERPLAIMTQLL-------PRSVEILGTHPLFGPGIKGLRIVLCQSRC-KNIGKVKKYLGQLGLKVILTTAERHDREMANSQALFHFLARGVAAMRIKLG...................................................................... 182
894 3.000e-27UniRef50_A0A1M5P4V5 Prephenate dehydrogenase n=6 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A1M5P4V5_9RHOB  ali  13  52.................................................................................................................................VTLSSLHSVSQADVILIAAPVSSF-ENVVSEIADACNPGALIVDVGSVKVVPAEIM-------RRMLPNHVDIVATHPLFGPGIEGLKVAVCPVQGNRHAQVAAFLRKALGLTVIMTTPEDHDQEAAVVQGLTHLIAKVLLRMGPLPTRMTTKSFDLLSEAISMVQHDAPEVFE------AIEKANPYA............................. 231
895 3.000e-27UniRef50_A0A1Y1RWG1 Prephenate dehydrogenase n=2 Tax=Spirochaetaceae TaxID=137 RepID=A0A1Y1RWG1_9SPIO  ali  14  37............................................................................................................................DSRIELVSEDK--LVDCDAVVLCVAISAM-EDVVRRLAGRLKPGALVMDTCSVKVYPVSVMK-------RLLPESIQILGTHPMFGPGITGLPLVYSPVRTDASADFFRDLFNSMRLQLVEMSPDEHDKSAAYTQGITHFLGRVLQDLHL-------EPSPMATLGYSKLLEIIEQTCNDPELFLDLQRYNPESLKSSLDRF..................... 234
896 3.000e-27UniRef50_A0A1G3AS38 Uncharacterized protein n=2 Tax=unclassified Planctomycetes TaxID=473814 RepID=A0A1G3AS38_9BACT  ali  15  4................................................................................................................................EVXXXICQSVSDSDLVILATPLCTF-EKIFAEIADALPDGCIVTDVGSTKVLPHRWAAGKL-------PNKVHYVGSHPIAGSEQRGVEFARTEKTNRQAVQVLKKFWLGLGCFIKVMKPAEHDRVFANVSHLPHLMAAALINA........................................................................... 152
897 4.000e-27UniRef50_A0A0C6EY98 Prephenate dehydrogenase n=14 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A0C6EY98_9RHIZ  ali  12  45..........................................................................................................................IAEAGA-VPATLAEAAA-CPVVILATPVSTLA-AVVEGMTPHLRPGALVLDVGSVKVRPAEIMRAGL-------PKDVDIVATHPLFGPGLRGLKIAVCPVRGERARRVGAFLRRALGLTVILTTPEAHDREAAAVQGLTHLIAKVLVAMEPL-------PTRMTTRSFDLVMQAVGMVHDAPEVYHAIERENPFSAEVRRRFFDLAA................. 241
898 4.000e-27UniRef50_A0A0M0BSD9 Uncharacterized protein n=2 Tax=root TaxID=1 RepID=A0A0M0BSD9_9ARCH  ali  14  22..................................................................................................................RGEEAREVASAVGAELKGTNIGAAGDADLVLISVPIPSV-GKVVSEVAPHMREGAVLAEVSSVKETTVRALRE-------AAAFGVKPLSIHPLFGPSLKGKTIVVVPVIDGDAAGLAERLFE--GAEIVVSEQEEHDRAMAVVLGLTHFMNLAFARVLSEA--DIASLKRLAGTTFTVQLAVAEAVVEEPGLVASLLREN................................ 215
899 4.000e-27UniRef50_E6VSI4 Prephenate dehydrogenase n=5 Tax=Desulfovibrionales TaxID=213115 RepID=E6VSI4_PSEA9  ali  13  6......................................................................................................ITSIAIVGAKGQMGNLFSGKFSALGCSVTPINRAALTGCDLLLLSVPVTAM-DAVLDRVLPFLAPPTILCDVGSVKMLPMKAMLDRYDGP---------VVGTHPLFGPVIPAVAVVPGRDTDRAAADAVSALFAACGYSCFDSTAEEHDRAMAIVQGLNFTSTVAFL----AAARDVDSIENYVTPSFRRRLDSAHKMLTMDELFEVISEANPFLQETNRKFMSYLSLAGDLDLLAE....... 245
900 5.000e-27UniRef50_A0A2V2D2F4 Uncharacterized protein n=1 Tax=Verrucomicrobia bacterium TaxID=2026799 RepID=A0A2V2D2F4_9BACT  ali  12  43...............................................................................................................RSESTRLKCSQMARIFDEVCETPSQAVSGADLTVVCTP-TDTIASIVGEIVPHLKPGAVVTDVGSVKSAICRDCSAALAGS------GADFVGSHPMAGSEKIGVDFAPCGASGADSAALVREFWESLGMRVEELLPAEHDRIVAHVSHAPHMLAGTLCRAVEKSLGDF--ALQFAGPGFRDCTRVVS---GSPDIWDAICMDNRAEITAALKE...................... 257
901 6.000e-27UniRef50_A0A2P8XUD8 Uncharacterized protein n=1 Tax=Blattella germanica TaxID=6973 RepID=A0A2P8XUD8_BLAGE  ali  12  409..................................................................VAAQSGHHVTLVEVNEAALEKAQSSILVNLKRVAKKLHK-----DNPEQAEKFVSDALK-HLKTSLNVMETVKNTDLV--------------------APEHTIFANTSSLSIQEIASVTNRKD-------RFGGLHFFNP--VPVMKLLEVIRTPDTSDETYEKMMAWGKSIGKTTVTCR-DTPGFVVNRLLGPYLTEAIRMLE............................................................................ 578
902 6.000e-27UniRef50_A0A1P8F534 Prephenate dehydrogenase n=2 Tax=Dehalococcoidia TaxID=301297 RepID=A0A1P8F534_9CHLR  ali  15  30.......................................................................................................EGFAVTIIGRDKDKL-AKAAIELGV-AATDRFERVAEADIVVLSVPI-DAFGSVCQSLAPNVGANHKVVDLTSVKTRPVDTMHLHFPRSI--------VLGAHPVFGPGAAGQNFILTPTSDPERAENISGWLAARGANVRIMPPEEHDRLMSISLGLAHFIAIITADALVSLDK-LTDMNGASGITYKALLTLVESVLSEDPLYASIQLNLPQI............................. 238
903 6.000e-27UniRef50_Q28LF2 Prephenate dehydrogenase n=17 Tax=Alphaproteobacteria TaxID=28211 RepID=Q28LF2_JANSC  ali  14  34............................................................................................................DLKAHDPRSDHHDVAANLGVRFTS--LEAVARCDMIVIAAPVSSF-EDVLVSIATVCRPGTLVIDVGSVKVHPADLMEKHL-------PDYVNIVATHPLFGPGIKGLKIAVCPIRGLKHWPLAVFLRKHLGLQVIMTTPHDHDREAATVQGLTHLIAKVL-------QRMGPLPSRMTTRSFDLLVEAVSMVTDAPEVFDAIEKANPYS............................. 232
904 6.000e-27UniRef50_A0A2A5WZV6 Uncharacterized protein n=5 Tax=Bacteria TaxID=2 RepID=A0A2A5WZV6_9BACT  ali  10  2......................................................................................................INNIGIIGGTGKMGTAFKNAFEGIGLKVSVSDERSLDNCDWIILSVPIDQ-TVSVYNRIKNNISKEQIFSDFTSVKSILSDQVKDC----------EFEFISCHPLFGPNFNGQNIVTIPVNASEKHIYIDKIFEKLDLKITQLDFEEHDRYMSLIQGMTHFSHVCFTTAMKKMNLDLDKIMDICSPIYQSNISFSSRITGGDELYTNIIMDNPDMYLDTSKEISSLVDNKDYESFKKNFIENRK 252
905 6.000e-27UniRef50_A0A2D6NW62 Prephenate dehydrogenase n=1 Tax=bacterium TaxID=1869227 RepID=A0A2D6NW62_9BACT  ali  11  29.....................................................................................................KPNHNIITANRSDKSKI----AKKLGIKYSDLNK--VCKQELIILAVPIREI-GNLIQKIQPMLKPGTILMDTCSVKEYPIKIMKKYL-------PADIEILGTHPMFGPGLRKLQIVFCPANQKENLEKIKAIFKNLALQIIQVSAKEHDKQTALSLCLVHFIGRGLGKMKTKL-----------EPIHTLNFNRLLKIQESVELFQDMQKYNKYAKEKSLINALQNIDKKLLSDKLK....... 255
906 7.000e-27UniRef50_A0A1Q9MUF0 Chorismate mutase n=1 Tax=Candidatus Lokiarchaeota archaeon CR_4 TaxID=1849166 RepID=A0A1Q9MUF0_9ARCH  ali  16  46...............................................................................................................................IQGTTDYTSGLTGANWILVAVP-LDVIVQVVQNSLPFIDKGAIILDILSVKGSVLPILGKVCKEV------GVQYVSTHPMFGPGMKDRNLIITPVPHEKAVAQVKEQFIAMGARVTEAGAEFHDKMMALVLNLPHFLNILFGKILASSGFEFPLIKQFGGTTFALQEFLSLNVAEDPAIYGQFQFENPA-------------FHDLLKEFQELIGQYTK 250
907 7.000e-27UniRef50_A0A0G0FKF1 Uncharacterized protein n=2 Tax=Parcubacteria group TaxID=1794811 RepID=A0A0G0FKF1_9BACT  ali  12  37....................................................................................................................KKYFEKAEKLGIKII--DKEDLKIFDIVILCPPISK-TEQIIKEIGPFLKEKSLLVDTCSVKTLPCQWMKKH-------APKNVEILGTHPMFGPVTTGLQIVLCPLRNQKKLEKIRKFLKKLKLKVIETTPQEHDRQNAKTLALVHFLGRALVTSGVKEQEIF-------TPGYADLLKIIPHTADNWQLFFDMNNFNPKDFLRSCHNLDFKKGKDDLESSRNIIDSVDE 274
908 9.000e-27UniRef50_A0A1J4SC25 Uncharacterized protein n=1 Tax=Deltaproteobacteria bacterium CG1_02_45_11 TaxID=1805124 RepID=A0A1J4SC25_9DELT  ali  17  18.......................................................................GMSIIEAFAQQGFTISGIEVNEEIIQRGMARVDKNLSKLVKKGKISDTDKEAVIKRIRMTTD-FEAVKDADVVIEAIFEDDVKKDLFARLDKTVASDALLTNTSSLSVSEIASATKRPEMV-------AGMHFFNP--VPVMKLVEVVRGAESSEDTVGKVVELAKLMGKVPIVC-KDSAGFVVNRMLHMFALEGCRIVEEGVASAKDVGARLGLGHPMGPFEL.................................................... 235
909 9.000e-27UniRef50_A0A256FSJ9 NADP oxidoreductase coenzyme F420-dependent family protein n=1 Tax=Ochrobactrum rhizosphaerae TaxID=571254 RepID=A0A256FSJ9_9RHIZ  ali  12  51...............................................................................................................................LSVTLTRMEDVARCDIVILAMPVARL-EHVVEAIAPHLRPGSLVLDVGSVKVSPANIMLSGL-------PDNVDIIATHPLFGPGIAGLKIAVCPVRGLQGARIGAFLRKNLALDVIMTTPEDHDRDAAMVQGLTHLIAKVLVQMEPLPTRMTTRSFDLIMQAVGM...................................................... 213
910 1.000e-26UniRef50_A0A151BP33 Prephenate dehydrogenase (TyrA2) n=1 Tax=Candidatus Bathyarchaeota archaeon B26-2 TaxID=1779371 RepID=A0A151BP33_9ARCH  ali  12  4..................................................................................AVIGGAGRMGRWLVKHFLNQGHELTISDPRLDDARAFAKHV---GAEVAASNIDAVKDADLVSVSVPI-EVTPKVLMEIAPSLKENTKFVEIASLKSHILPILKEIAES------RGVRTISVHPLFGPGVQRLRIALIPVSELEATEEARRLFP--GAEIIPVDAETHDRAMALTLSVPHFINIAFASLLGE--ENLKLLKRLGGTTFTLQLILSEGVMSEDPLYASIQMNNDYTVR------YLDRLLTRMKTIKDMIARGDE 253
911 1.000e-26UniRef50_S5YR38 Prephenate dehydrogenase n=4 Tax=root TaxID=1 RepID=S5YR38_PARAH  ali  15  27........................................................................................................HVAVSVIDPAPEAQARLRAEGLGA----TELAGLAEVDLVLLAVPVPALA-SCLREIAPHLRAGQIVIDTCSIKEEPARLMRDLL-------PEFVEILPTHPMFGPGIAGLQIVLCPEGGDGWRPIAAFLRRALGLSVRRATPVEHDRQAAVTQGLTHLLARAFGELGPR........................................................................ 190
912 1.000e-26UniRef50_A0A2G9XIL1 Uncharacterized protein (Fragment) n=1 Tax=Syntrophobacteraceae bacterium CG23_combo_of_CG06-09_8_20_14_all_50_8 TaxID=1974096 Re  ali  8  1....................................................................................................................................................................MKNDSLLMDLTSVKVEPVRAMLSFSSA---------EVIGCHPLFGPSLEKQHIVLCPVRTKKWLPWLRDVLEKGGASLVETTPEKHDELMSVVQGLNHMNTIMMGMALSKTSAPISRLDPFTTPFLDIKAKMVKKIFSDNPLYAEILCNNPEIYEQMISKIGSAILSGDTEGLTELLQKTS. 183
913 1.000e-26UniRef50_A0A1Q7LS11 Uncharacterized protein n=1 Tax=Crenarchaeota archaeon 13_1_40CM_3_53_5 TaxID=1805098 RepID=A0A1Q7LS11_9CREN  ali  12  98...............................................................................NKEILIIGGTGAMGQFFSRFITANGGTVTIVGRDQRR--TLKTAEDLAVKPGR-LLDAAS-SDIVIVAVP-MKSTRQVCIRAANRMRSGALLIDLCSVKSGIADIIA-------VQTPSRIEYVSLHPLFAPHLDGQNIAAVSYRTGPQWDRLSRTLTGSGARIIKMTCDYHDRTMALVQVAHHYALLSLGNSLK------GWSGDLKTNSIKRTIATVRSLLGNWDTIIGIQQLNPYA............................. 321
914 1.000e-26UniRef50_A0A2N2IDH4 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Deltaproteobacteria bacterium HGW-Deltaproteobacteria-18  ali  12  7.......................................................................................................SQIVVIGAKGQMGARFVLSFREAGHFVTDALPDAVRKAALVLLCVPITAMKETVA-LVAPYLTQETILADICSVKVQPLHDMLTPTTTPVVGT---------HPLFGPHTAELRIAVTPGRDQSATDNLSNCFRDLGFAPFTTTADEHDKAMAYIQGLNFVTTIAYL----CASPLENGIERFFTPSFGRRVEAATKMITQDPLFSTMFEANPHSLEA.......................... 221
915 1.000e-26UniRef50_A0A0F9CLY1 Uncharacterized protein (Fragment) n=1 Tax=marine sediment metagenome TaxID=412755 RepID=A0A0F9CLY1_9ZZZZ  ali  13  24.....................................................................................................KQHGFKVTLFARNKNKLK-DVAGELGVNYELNLKKSVENTDIVMISIPI-KTTPEMIKNIASLMKKNSLLFDITSLKREVFKVFSEIQNKYP------INFLSLHPMFGSGMKNYNIIALKVGGTEQVNELLDLFRSDGLIITETTPEIHDLRIALTLCVPHMFNILFLNLLRKTNEPLNELTKYTGTTFLLQKVFAESIIQR........................................... 225
916 1.000e-26UniRef50_F8F0F0 Arogenate dehydrogenase (NADP(+)) n=1 Tax=Treponema caldarium (strain ATCC 51460 / DSM 7334 / H1) TaxID=744872 RepID=F8F0F0_TRECH  ali  13  45......................................................................................................................................LEALGNCPIVFLCVTIRAV-PEVLQVIAPYLAKNTIIADTCSVKVLPGKWLLEYL-------PQETPILATHPMFGPELEGLAIMIDPLRDARQAQFWEDVFAGLGLTVVRMTCEEHDREAAYSQALTHFVGRSLYR--------IGLPETPIATRWYKKLHSVAKVRDSHVLFEDMQTLNPFA............................. 220
917 2.000e-26UniRef50_A0A2J4Q060 Bifunctional chorismate mutase/prephenate dehydrogenase (Fragment) n=3 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A2J4Q060_9ENTR  ali  14  13................................DEVDKALLELLAKRLELVAEVGEVKSQYGLPIYVPERESAMDLIADVLRRVMRESYSSENDKGFKTLYPNLRPVVIVGGGGQMGRLFEKMLTLSGYQVRSKAEEIVADAGMVIVSVPI-HITAATIAQLPP-LPADCILVDLASVKAEPLQAMLAAHKGP---------VLGLHPMFGPDLAKQVVVYCDGRQPEAYQWFLEQIQVWGARLHRISAVEHDQNMAFIQALRHFATFAYGLHLAEENVRLEQLL............................................................... 278
918 2.000e-26UniRef50_A0A2E1A902 Uncharacterized protein n=1 Tax=Anaerolineaceae bacterium TaxID=2024896 RepID=A0A2E1A902_9CHLR  ali  17  51..................................................................................................................................ATSIAEAIADADMVILAVFVEAIM-DILTEIGPLLKPGAVVLDVGSTKAQIIEAM--------NLLPEGVQAVGGHPMTGRLTQGVDFALCPHTSVDTKNQVTDFVESLGAKPLWLDAYQHDEYVAMVSHLSRLLPIAVMSAASQKD-------DLIWQLAAGSFREMTRMASEPGFWRDVFATNPAGI-----STNLRDVANQLEQFAQLIEAGD. 259
919 2.000e-26UniRef50_A0A1G3ZNT2 Prephenate dehydrogenase n=1 Tax=Verrucomicrobia bacterium RIFCSPLOWO2_12_FULL_64_8 TaxID=1802434 RepID=A0A1G3ZNT2_9BACT  ali  14  51................................................................................................................................EVRDSPEEAVRGAQFVVLAPPVEKIIP-LTQAVAPHLAPGTIVTDVGSVKGEIARQGHAAM-------PPGTHFVGSHPMAGSEKTGRTCFVTPLTDPHAVDAVVRFWHELGAEVTTIDPDAHDEIVAHISHLPQVVATSLCDFLAR........................................................................ 202
920 2.000e-26UniRef50_A0A2H5XPT3 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=bacterium HR19 TaxID=2035414 RepID=A0A2H5XPT3_9BACT  ali  15  15.........................................................GVMGFGISVVLLNNGFSVT-------VVEKDEQSLQRGLEHIRKFYESGIK------RGKISEEKVKDNLSRLKTTKVEDIPHDSLVIEAVNEDSLKQDVISRVESVVSDEMIFTNTSSIPVIEISAVMRRPE-------RFLGFHFFNPP--PVMKLIEVIPSLKTDERYISFAVEFARKIGKEPVI-TKDTPAFIGNALLIPFILEAIRMEDIDKACKLGLGYPMGPFELADFMGLDIVLAIADNVYRRTGDDRFRPSAKLRELVSAGFLGRK............... 277
921 2.000e-26UniRef50_A0A0A0E0C2 Uncharacterized protein n=3 Tax=root TaxID=1 RepID=A0A0A0E0C2_9SPIO  ali  12  51............................................................................................................................................APVVILCVTISAM-EEVLEKIAKLLAPGTLVMDTCSVKVYPANLML-------RLLPPEIEIIATHPMFGPGITGLPMVFSPMRVDERIAQLWSSFEAMGLKVIDMSPKQHDEEMAFSQGITHFIGRVLGE-LDLNSSIIGTA------AYKKLLDIVQQTCNDWDLFVDLQRFNP............................... 218
922 3.000e-26UniRef50_A0A1W9WQ64 Prephenate dehydrogenase n=3 Tax=cellular organisms TaxID=131567 RepID=A0A1W9WQ64_9DELT  ali  9  45....................................................................................................................................TLEEACRE-KVVILSVPISNM-REMLRRIAPLLRPDAMVVDVCSVKVYPIEWMRDAL-------PASVSLLGTHPMFGPDLHGHKIVLCKDRNASCYGKVKAYLTGKGLKVIDATPEEHDRQIAVSLSLTHFIGRALDEFGAELMIDTEGYKRLLHILGVVTHDT-------WQLFVDMNRYNPYARENRQAFMAGMKRLE.............. 236
923 3.000e-26UniRef50_A0A1F8ML23 Uncharacterized protein (Fragment) n=2 Tax=root TaxID=1 RepID=A0A1F8ML23_9CHLR  ali  14  47...........................................................................................................................KNLAVNTAASNAEAIKNADYILLSVPIENL-ETVVKEISQQVQDWQTVIDITSVKTRPVDIMHRYI--------KKGTVLGAHPLFGPGAKGINFVLTPTQEKEAARRIAGYLEKHGGRVAVMTPEQHDEMMSLVLGLSHFIALVAADTLLSSGE..................................................................... 197
924 3.000e-26UniRef50_A0A1N6WR61 Prephenate dehydrogenase n=4 Tax=Alkalispirochaeta TaxID=2024958 RepID=A0A1N6WR61_9SPIO  ali  14  27.....................................................................................................................................PLEKALDAPVVFLTVAISAM-PGVLRTIAPLLKPGTVVVDTCSVKVYPVRQMKELL-------PDSVDIIASHPMFGPDSARLPIILWPVRNRQRYDELRTTFEGLGLRIVEMSPEAHDQEAAFTQGVTHLVGRVL-RAMDLEPSDIGTLG------YRRLLQVMDQTCNDPELFRDLQRFNPSTEMREAFSRAFCQVENLL............ 221
925 4.000e-26UniRef50_UPI0004775657 prephenate dehydrogenase/arogenate dehydrogenase family protein n=2 Tax=Sporomusaceae TaxID=1843490 RepID=UPI0004775657  ali  15  58.......................................................................................................................................EAVEQADIVILATPVLQMA-SLMTEIAEKLPAGCVVSDVGSTKSAVSETLESLL-------PERCSYIGGHPMAGGERSGMEAAPGKRASEEQVELLRDLLLPLGAKVAVMHPQEHDQWAAVISHIPHVTAAALVHLLARAELGDARV-----QMAGGGFRDTTRIASSDDMWADICISNAEHIHRQ-----IGKLQEILAECAQAVESGDR 265
926 4.000e-26UniRef50_A0A1Q6ULK5 Uncharacterized protein n=3 Tax=Verrucomicrobia TaxID=74201 RepID=A0A1Q6ULK5_9BACT  ali  14  54.................................................................................................................................VRSEPEEAAEDADLTVICVPTENI-PELAAKIAPSLKEGSLVTDVGSVKGKICRLCSESVGAF------GARFVGSHPMAGSEKIGIDFAVTPLSDECAAAAVSEAWRALGMRVYTVSPQLHDAIVARVSHLPHLAATLVCDVAADFDMNL---LPYSGPGFRDTTRVAS---GSPQIWESIVADNRDEILS-----ALGDFSSRLGALIGAIKSGDK 266
927 4.000e-26UniRef50_A0A2C8FAT6 Prephenate dehydrogenase n=3 Tax=Desulfovibrionaceae TaxID=194924 RepID=A0A2C8FAT6_9DELT  ali  14  13.............................................................................................................GANGTMGSLFRDKFTEIGCRVTEAIRDALADCQLLLLCVPVTAM-GDVVDRFKPHMLDSTILADVGSVKVGPMKAMTERHDGP---------VVGTHPLFGPEAPRVAVAPGRERDDQAAQQVCQLFADCGYESFMTTADEHDRAMAFVQGLNFTSTVAFL----AATRDIPSIKNFVTPSFKRRLDSAHKMLTVDELFETISEANPYLQETNRKFMTYLSLAAG--GDLELLTNRAQ 248
928 4.000e-26UniRef50_A0A1F3BDP2 Uncharacterized protein n=1 Tax=archaeon RBG_16_50_20 TaxID=1797286 RepID=A0A1F3BDP2_9ARCH  ali  12  36....................................................................................................................SVARTVARKRNLRFAEDQKRAIRSSQIIVLATP-TQATRKILNQVSEFLAPESLVVEISSVKE-PLRRILQRL------RKRGVPILSIHPMFGPGLKGRTVLATSIPSRNHARRILSLFRKRGAKVILCSIKEHEALMSALLTLPHFLNLVMVNTLRVMRFDPDRLRELSGTTFRLQL-LIAEAISQENLENE-----ASIFIDNSQSMKVLQKYRQCNAALSMLKKGKR 257
929 4.000e-26UniRef50_A0A1L3I7I7 Prephenate dehydrogenase-like protein n=2 Tax=Rhodobacteraceae TaxID=31989 RepID=A0A1L3I7I7_9RHOB  ali  12  53...................................................................................................................................TSLAKAAA-CPLVILAVPVSALA-ALCRQISPDLRPGTVVMDVGSVKLTPCETMQQLL-------PPDVELLGSHPLFGPGIAGHKIALCPLRGNSHRHIAALLRHLFGLKVITTTPADHDRELAIVQGLTHMIAKVLDQMTPGKLGMTTASFDL--------LQQASRMVDSPGVLGAILRDNPFAAEVRDDFLRRAAQLGAIDNSTTMSPAKEK 258
930 4.000e-26UniRef50_A0A0P1ERM2 Arogenate dehydrogenase n=99 Tax=Proteobacteria TaxID=1224 RepID=A0A0P1ERM2_9RHOB  ali  13  58..............................................................................................................................GQRLTLQGLAEVAQSDIVILAVPVSAMA-HVCRVLAPHLRPGTLVVDVGSVKVAPMQDMQ-------RLLPAHVEILGTHPLFGPGIAGHKIALCPVRGSKWRRVAAV-LRRRGLQVLVTSAQDHDRELAVVQGLTHMIGKVLSDLGPMPERLTTASFDLLREAVRMVQDDPPTVLH------AIEVANPYAAEVRN---AFFERAEELKAQFE....... 258
931 5.000e-26UniRef50_A0A2M7L0F5 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Armatimonadetes bacterium CG_4_8_14_3_um_filter_66_20 Tax  ali  20  21..................................................................................................LAAKKRGLTRRVIGVARTDHTLAIARERGCETTPDMAEAVHDADLVVVATPVGSVSGA-LERIAEHVRPSALVTDVASTKATICEAADRLLTGRAR-------FVGGHPMAGDDFEGCVWALTPTTSGEAVERLTEFAGCLGARIVELDPAAHDRLVAATSHLPHVASALTASGFRDTTRVAGAPADLWDDIVLDNAQAIAALAQLSALRGAVAARDESAIHAFLDQ...................... 277
932 5.000e-26UniRef50_L1IPV3 Uncharacterized protein n=1 Tax=Guillardia theta CCMP2712 TaxID=905079 RepID=L1IPV3_GUITH  ali  14  61......................................................................................................................................IERVRSASVIISCLPPGPCVRA-LEALAPHMASGALFTDVLSVKSGICSAYSE-----LKDKYPHIELLSVHPMFAPGWQGQNTVSIHIRTAGRSKAFEALIESWGSTIVPMSGELHDRVTSAVQNATHAALITFGLTLKKMGYDAGLAKKISTPPHRAMIAVIQRMINEPDTYWDIQTENPDAF............................ 244
933 5.000e-26UniRef50_A0A2M8LEA3 Uncharacterized protein n=1 Tax=Candidatus Uhrbacteria bacterium CG10_big_fil_rev_8_21_14_0_10_48_11 TaxID=1975037 RepID=A0A2M8LE  ali  13  40................................................................................................................................SITQRNREVVENADVVIFAVP-PHLLPDIVRSVVEVSRADQLWIDCSCLQSEPVRAVLESRA----------EVVGLHPMCAPTKEGQTVIVCQARLRQWRTWFEDFMKKTGAHSKVSTPEEQDKNMVIIEGLIHANVLIMAGLLRRLKVNVTDVMEHMSPIYKLSFSFLGRIL............................................. 205
934 5.000e-26UniRef50_UPI000DCBA834 3-hydroxyacyl-CoA dehydrogenase family protein n=1 Tax=Halorubrum sp. 48_1_W TaxID=2249761 RepID=UPI000DCBA834  ali  14  39........................................................AGTMGHGIAVALAGDGRSVTLYDVDEDALEAAREAIADAVATLAEHEGHELEDAERVLGS-----------IAYDSTLSTAVADADLVIEAVPEDEIKLDVLGRIEREAPSRAVVTNTSSFSITLLADALDRPE-------RFLGTHWFHPPHI--VPVVEIVRGEATADGPVRAVRTLLEDAGKTPVVVEKDVPGFIGNRIQSAMAREAWALLDEGVASAEDIDAAVK.............................................................. 249
935 5.000e-26UniRef50_A0A0A7LCL2 AroQ protein n=1 Tax=Candidatus Methanoplasma termitum TaxID=1577791 RepID=A0A0A7LCL2_9EURY  ali  14  77...................................................................................LIDSSVELQSGLLNKKCEK--KISIVGGSGGMGQWMKRYFERMGAEVSSGSPTDAEDSDVVIISVPPSAIS-ATLKKMVPFCKEDALIFDISSIKSPFADDIKE--------MAKHRKVCSVHHMFGPSAKDRNVVICDCGCKEAVSEVADLFDSEGSNLIFTSIERHDELMAYVLAFAHASNIVFFTTLRESGISFDELNKIASTTFKRCLNASVPVSEENPLYHEIQRLNDDVFEKAFKEVKKASLSKDPDRFIEIMESGKE 344
936 5.000e-26UniRef50_A0A1U1DTH1 T-protein n=4 Tax=Mycobacteroides TaxID=670516 RepID=A0A1U1DTH1_9MYCO  ali  14  56...............................................................................................................................LRLEPRLRAALSDADLVLLALPEA-VACGAIPVIAPLVKPAALLADTLSVKATVA--------RTWISVGADVEALSVNPMFAPGARGRPIAAVVLRDGPRIQALVKMMQNWGANVVLMDSDEHDTMTAAVQALTHASIIGFGLALRAIGIAPAQLVRVAPPPFQAMLALLARIADTSEVYWEIQDANPYASAAREALTTGLKKLNDVPSFTEMLAEIAD 274
937 6.000e-26UniRef50_A0A1V5E075 Putative 3-hydroxybutyryl-CoA dehydrogenase n=4 Tax=Deltaproteobacteria TaxID=28221 RepID=A0A1V5E075_9DELT  ali  15  14........................................................AGDMGHGIAASCLMGGYEVVLRDIDRKFVDKGVARIKDSFDKFKE-------------KGKMTPAAYAETLSRLTSDLQAAVQSADFIVEAVPEKELKKSVFADLDKFAPPQAVLANTSNISISDIASATSRPE-------KVIGYHFFNPAIL--MKLVEVIKGKKTSDESIAIGCDIARKINKIPVVVKKDSPGFIFNRVNEPTGALLSKILEAGRPAPEEFDAAMKPVMPMAPFELDYVGIDVAVHGLEYFAAVLSGEALMDYMKKGNLGKK................ 276
938 6.000e-26UniRef50_C4RL65 4-amino-4-deoxyprephenate dehydrogenase n=7 Tax=Actinobacteria TaxID=201174 RepID=C4RL65_9ACTN  ali  15  58......................................................................................................................................AEAVTRADLVLLAVHEQVALKAV-GPVTDLMRPGAVLADTLSVKTRMAAELEARAI--------DIQHVGLNPMFAPGMPGRPVAAVVTQDGPGVTALLGLVERWGGRLVRCTPEQHDRTTAASQALTHAMILSFGLALPKLGVDVEQLTATAPPPHLTLLALLARVLDSPEVYEEIQRANPYA............................. 235
939 7.000e-26UniRef50_A0A0Q4X701 Prephenate dehydrogenase n=4 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A0Q4X701_9RHIZ  ali  11  9.........................................................................................................................................VAYCPVVVLAAPVSKLA-EVVSAIGPHLRPGALVLDVASVKMVAARIMAEGL-------PDHVGIVATHPLFGPGLKGLKIAVCPIRGRGGLRAAAFLRKHLGLDVILTDPEAHDRAAASVQGLTHLIAKVFVEMEPLPTRMTTKSFDLLMQAVGMIRNDAPEIFD------AIERANPYAADVRRRFFAHASRLER............. 196
940 7.000e-26UniRef50_A0A1I7C154 Prephenate dehydrogenase n=88 Tax=Bacteria TaxID=2 RepID=A0A1I7C154_9RHOB  ali  13  48............................................................................................................................AAEFGVSSGPLNVVSQSDIVVIASPVATF-ERVVTSIAAVCRPGAIIVDVGSVKTQPSEIMK-------RLLPDDVNIIATHPLFGPGVRGLKIAICPIQGKLHSRFAAFLRKELGLEVIITTPDEHDRDAAIVQGLTHLIAKVLLSMEPLPSRMTTKSFDLLSEGISMVQNDAPEVFE------AIEKANPYAEDVRRRFFNLAAK................ 245
941 7.000e-26UniRef50_A0A1V4ZFV6 Prephenate dehydrogenase n=3 Tax=unclassified Methanomassiliicoccales TaxID=1577790 RepID=A0A1V4ZFV6_9EURY  ali  18  137..................................................................................................................................VTELAPAVKRADVIIIAVPISQA-PGIIDRIVEAEPRG-LVFDIMSVKEPLI-------PHLKRAVEEGLTVCSVHPMFGPSMYSRNIIVCDCGSHKAVEEFLPLVEGMGCNVTEMPLDEHDKLIAYVLGLSHAANIAFFETLRLSGTEFKSLEVIASTTFRNQATTSRKVAENPDLYYEIQHENPY.............................. 318
942 9.000e-26UniRef50_A0A0R2XIV6 Uncharacterized protein n=3 Tax=Verrucomicrobia subdivision 6 TaxID=134627 RepID=A0A0R2XIV6_9BACT  ali  13  50..............................................................................................................................NAEIGTDP-SLVRGSDLVILAAPPSAL-PTLIQSILPHLSPHTLVTDVSSIKLSVESSVAPLLQGQAR-------WIGSHPMAGSEESGIQVILTPSTSADTLQDATSFWKSLGARVLSMSPAQHDSYVALISHLPHCIASTLVLAAGTS------PLPLAGSGYRDTTRVAG---GPSALWAEILLSNRTEILASLQTFH.................... 245
943 9.000e-26UniRef50_A0A1G6B1E3 Prephenate dehydrogenase n=4 Tax=Desulfovibrionales TaxID=213115 RepID=A0A1G6B1E3_9DELT  ali  11  13................................................................................................SRAVDRISRCCVIGSGGRMGGLFVARLRKAVIETAPLLAEVLPSQDLVLLAVPAPAM-EEVLVKCAPHCRPDAILVDICSVKVQPLRLMLQYHPGP---------VVGTHPLFGQDPEAPRVAVVPGRDDQATQTVSSVLEDLGFQTFPTTAETHDRAMAAIQGLN----FVTTAAYLAALAGDDGLRDFLTPSFERRLEAARKMLTEDALFADLFEANPYS............................. 230
944 9.000e-26UniRef50_W0E8V6 Prephenate dehydrogenase n=1 Tax=Desulfitobacterium metallireducens DSM 15288 TaxID=871968 RepID=W0E8V6_9FIRM  ali  14  72...........................................................................................................................................EADLVILALPIHLLNEG-LEHVLERVCEGAIITDVGSVKTEVCQSDIQR---------RHVYFIGGHPMTGSEKSGVQYVLVPRATSPQVDKLEALLHQIGAKVVLRTPEEHDRQVALVSHLPHLFAVALTLAILEESPNETSSIELAGRSFRE----MTRIADSSPMWQEILIRNASAVLASLD-----VWQGKLDEIRSWLEEKN. 273
945 1.000e-25UniRef50_A0A2V3U1H3 Prephenate dehydrogenase n=1 Tax=Chelatococcus asaccharovorans TaxID=28210 RepID=A0A2V3U1H3_9RHIZ  ali  9  61.........................................................................................................................................VARCPIVVLATPIDGL-EEVVAALAPHLSAGTLVLDVGSVKVIPAAIMK-------RGLPADVDIVATHPLFGPGIAGLKIAVCPIRGRRGLRVAAFLRRALGLDVIITTPEAHDEDAAVVQGLTHLIAKVLVRMEPL-------PTRMTTRSFDLIMQAVGMVRDSPAVFQAIERSNPYSAAVRDRFFRLAAALK.............. 247
946 1.000e-25UniRef50_A0A2S9X1T4 Uncharacterized protein n=2 Tax=Chromobacterium amazonense TaxID=1382803 RepID=A0A2S9X1T4_9NEIS  ali  14  59.....................................................................................................................................LEHAFARADTIIVALP-DCVARAALPWVAGHVRDEAVIVPTCSVQQPFFHDLASIKPGHPC--------LGLNPMFSPSLPGRVVASCLPDPESTSHWLEQSVQEAGMRVKRLSPERHDQLMSVCQTLPHAAIIAFGLALSDSGVDLDSVMEMAPPPMRAMLALLSRILSNPEVYWDIQSENPHALSDSLRQLSSMVEAKDGGAFSQELQRTAD 274
947 1.000e-25UniRef50_A0A0S8IEK4 Uncharacterized protein n=1 Tax=bacterium SM23_31 TaxID=1703762 RepID=A0A0S8IEK4_9BACT  ali  13  56...................................................................................................................................DNLGSVLKDVDLIILAVPIRKI-CAFIPEIIPIVKQGCIITDVGSTKHAIIAV-------SNTFSREGVFFIGGHPMAGSEKTGFEIVKGENTPDEIVTKISEMVTKIGAIPIQLDSKTHDRIVAGISHLPQMLAIALMNVIGKENDQDKRFFQMSGPAFIEMTRIAGSSFS............................................ 232
948 1.000e-25UniRef50_A0A124FHG8 Prephenate dehydrogenase n=1 Tax=Acetothermia bacterium 64_32 TaxID=1635286 RepID=A0A124FHG8_9BACT  ali  15  41.....................................................................................................................................LSAAVAGSDLVFLATPI-KVILELIPKVAPHMQEGAILTDLGSTKTEICRLARER-------VPDGVHFIGGHPLTGAEGRGILYVLCPLPGEGALPPLRGFLERLGAIVVELAPEEHDRIAAYVSHLPQLLAVALVNLVGREEGFL--------RFAAGGFRDLTRIASSPGIWEDILSTNAPFIKQALGDLLLSKLGERLEE.......... 243
949 1.000e-25UniRef50_A0A0K0WLS9 Uncharacterized protein n=7 Tax=Leptospirillum TaxID=179 RepID=A0A0K0WLS9_9BACT  ali  14  56................................................................................................................................SYTPSNREVVSGAELVVIAAPPSSI-PKIWEEIGPGLPPGTLLTDLASVKQNLHAIYLERFSSVFPR------YISSHPMAGRELTGVDAARADLFRDEDLERLKKLWTIAGSRQTVVESREHDRILSLISHLPHLLAFSLLETLVRTTDKKTIPHWNWPSQKGGALKDMLRIASGPDLWGDILLQNRKEILSSFKKFLVDEDREGLISCLKTLQAK.. 291
950 1.000e-25UniRef50_Q72EV4 Prephenate dehydrogenase n=31 Tax=root TaxID=1 RepID=Q72EV4_DESVH  ali  13  2........................................................................................................KIALVGDKGRMGRLLTSRFSAAGCEVADTVRPAVQGADVVILCVPV-EVLAEVLSIVAPLLSPKQVLADITSVKVRPMEVMQAFHAGP---------VVGTHPLFGPDPQDVAVTPGSSARDADVTLVEQCFRMIGCDTFRTTAQEHDRAAAMIQGLNFISSVAYLATLAHN----EELLPFVTPSFRRRLDAARKMLTEDALFEGMFEANPASAVRSFRSFLNIASAGDVDVLVD....... 238
951 1.000e-25UniRef50_UPI0003746EE0 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Hyphomicrobium zavarzinii TaxID=48292 RepID=UPI0003746  ali  12  73.........................................................................................................................................AARADVVVLAAPVQEM-RAIAHAIAPHLKEGALVLDVGSVK-------CLPAAALAEELPAGVSIVGTHPLFGPGVHGHKIVLCPVRG-AGLGDVRSWLRSLGLRVLVRTPEQHDREMAVAQGLTHMIGKLIA--------DMGVVPSITTPSFDHLLA-AARMVSSDAVFTAIQRDNPFVAEVQDRFFALAE................. 254
952 1.000e-25UniRef50_UPI00050BFFA5 prephenate dehydrogenase n=1 Tax=Rhodococcus fascians TaxID=1828 RepID=UPI00050BFFA5  ali  12  51..................................................................................................................................TKKLWEVLESADVVVLAVPE-DIAVGALPVITAGLRPGTLLVETMSVKTALVQHLRGHH---------DIEIVGINPLFAPDLRGRSIAVVEERSGPRSARFLRLLTEGGARLLFTTADEHDRATATTQVLTHATVLSYGVALAHSGCEMTTLSDFATPPSTMLTALLARMTENSPVYWDIQFHNPHALAQSLRRIADTVESEDHAQFAEYLATVE. 265
953 2.000e-25UniRef50_A0A2E5DTY5 Prephenate dehydrogenase n=1 Tax=Alphaproteobacteria bacterium TaxID=1913988 RepID=A0A2E5DTY5_9PROT  ali  14  54.........................................................................................................................................AAQSDIIIIATPVKTI-HQICKDIAPHLSEGQLVMDVASVKSQPAETMQA-------TLPDYVDLIGLHPLFGPGIHNQNIALVNLRGQRASGVTQFLEGTLHLNVIPCTAAEHDQQMAYVQGLTHMI--------GRIMRMMDIPEITQETKTFSLLRQMSDLVDSDALFKAIQTDNPYV---ENTKEQFFTAVKDLEDSLK....... 244
954 2.000e-25UniRef50_A0A1F7YXY5 Uncharacterized protein n=1 Tax=Candidatus Woesebacteria bacterium RIFCSPHIGHO2_01_FULL_44_21 TaxID=1802503 RepID=A0A1F7YXY5_9BAC  ali  12  21.....................................................................................................................................LVDKIEEADIVFPCVPI-RAFEEVIKEISPKLKNGALVIDVCSVKVHPVKVMKKHL-------PKHVQIIASHPLFGPGLAGLKIMLWNVAKKSTFNKIQTSCRKLNLQIIEITPEEHDKFMAFSLAYTHFI-----------GRIGKDMKIMSTPIDTEGFKQTLKIQDSEELFIDMHRFNPDAMRKKFIEAVIKLDNKI............. 215
955 2.000e-25UniRef50_A0A0G2ZNZ2 Prephenate/arogenate dehydrogenase n=3 Tax=Archangium TaxID=47 RepID=A0A0G2ZNZ2_9DELT  ali  12  56..................................................................................................................................TPELLRQVAGADCVLAALPEPAILAA-LGSVVPAMRPGTLFVDTSSVKSEIVERA--------GHDARAVEFLSINPLFAPSVPGQNVAVVGERGGEKAREFVALMEGWGGRVVPFTAEEHDRSMACIQTATHAAVLAFGLALRELDYQPRWISDATTPPHRLLLGLLARITANPEVYWEIQRANPFA............................. 237
956 2.000e-25UniRef50_A0A1B7XGE0 Prephenate dehydrogenase n=3 Tax=Desulfovibrionaceae TaxID=194924 RepID=A0A1B7XGE0_9DELT  ali  15  1...............................................................................................MQEIDFRLKKVAVVGATGKMGAMFCTRFANAGLEVTDDVLQAIAEAQIVLVCVP-AAVFNDVVKRVTAHMKPPQILADITSVKVQPMMQMQKAYTGP---------VVGTHPLFGPEPKRVAITPSEGCDAESARMVEDLFTSIGCEPFCSSAEEHDKAAALIQGLNFVTSVSYLALLA----DKENVIPYLTPSFERRLKAAEKMITKDELFEGLFEANPSSAVRSYRSILNIAAGGDINVIVE....... 246
957 2.000e-25UniRef50_Q8TVM3 N5,N10-methylenetetrahydromethanopterin dehydrogenase (H2-forming) n=2 Tax=Methanopyrus TaxID=2319 RepID=Q8TVM3_METKA  ali  24  60......................................................................................................................HVDRVADAGVELTEDDAQAVEGAEMVVLFTPFG-ATGGIIREIASHLEEGAVVCPTCT---SSAFEIHESLYEAGLEVPEAVGVMPAHPAGIPGTENHRAYITALATEEQAELVEEVLSSTGKEVFELP---HVELVSVVGDLSVVLLKRVIEALKEAVKALGAPQEMIDRQAMMTLATLAALIEAGGIGGLLETLDEEAIEASYSNM..................... 270
958 2.000e-25UniRef50_B7QPG4 Prephenate dehydrogenase n=4 Tax=Rhodobacteraceae TaxID=31989 RepID=B7QPG4_9RHOB  ali  11  48.............................................................................................................................ARVRFST--LEDACSCPLVILAVPVSSIS-DVCQRIAPLLAVGATVMDVGSVKLRPMQDMETHL-------PAHVNILGSHPLFGPGLAGHKIALCPQRGRTHWRIAAALRSLFGLHVIWTTAEDHDREVATVQGLTHLIAQTLSQILPEKLRMTTSSFDHLLEARRMVSADAPAVLD------AILCDNPFAAEVRADFLS.................... 238
959 2.000e-25UniRef50_A0A0G0J0I3 Prephenate dehydrogenase n=1 Tax=Parcubacteria group bacterium GW2011_GWA2_38_13 TaxID=1618811 RepID=A0A0G0J0I3_9BACT  ali  12  50.........................................................................................................................................VCLADIVIIACAISDF-EKTVKEIRNFLRHGTIVMDVCSVKIMPCVAMKK-------YFPKKIELLGTHPMFGPGLIGLKMVLCPVRSDENLSFIKNYFKKLHLEIIETTSKIHDKESARSLCMVHFLGRGL--------EKLNIKKMPISTMGYERVLQVSENVTNDELFRDMQKYNPYAKVERERLLKALNRIN.............. 237
960 3.000e-25UniRef50_Q6L096 3-hydroxybutyryl-CoA dehydrogenase/3-hydroxybutyryl-CoA dehydratase n=8 Tax=Thermoplasmatales TaxID=2301 RepID=Q6L096_PICTO  ali  16  12........................................................AGLMGHGIGEVFALNGYNVNLYDSFPAAIENAKKSIDNSLSRLLNS-------------GKIKKEDLNEIRIKFHGNLDEALMDSDLVIEAVPELDIKTSVLSEVSKKT-DSIIATNTSSIRISEIAEHIDKPE-------RFLGMHFFNPPVV--LKLVEVIRGEKTAESVFNEVYNLAKSIKKIPIKVMKDTPGFVVNRISGLFCFIYQSGLAKPEEVDSYIKAPMGPYELFDYVGLDVIKDLFDYYGNE....................................... 250
961 3.000e-25UniRef50_A0A1F2Z096 Uncharacterized protein n=2 Tax=unclassified Alphaproteobacteria (miscellaneous) TaxID=33807 RepID=A0A1F2Z096_9PROT  ali  13  42............................................................................................................................EATYHLTVTSLEDVSKCDIVVFAVPVKELEKTVAS-VVPFLKAGQLVIDLCSVKCKPV-------EILKRLIPAGVDAVSLHPLFGPGISGLNVTVCNVSGDRAPCIIAFLKDKLSLNIFETTPENHDQEMAYVQGLTHMIAKVFVRM--DVPDIHQQTKTYAHLNDMVELIR----YDSEELFLAIQRDNPYVRETTEKFFAAVKALE.............. 241
962 3.000e-25UniRef50_A0A1S1KZ46 Uncharacterized protein n=3 Tax=Mycobacteroides franklinii TaxID=948102 RepID=A0A1S1KZ46_9MYCO  ali  16  45.....................................................................................................................................LRAALADADVVLLALPE-DVACAAIPVLVPMLKPGALLADTASVKT--------NLAATWTSIEADVEAVSLNPMFAPGVRGRPIAAVMLRDGPKAQALVTMMQNWGADVVVMDADEHDEATASMQVLTHASILGFGLALREIGTDPAQLASIAPPPFHAMLALLARIAGTSEVYWDIQDANP............................... 221
963 3.000e-25UniRef50_Q11VM0 Prephenate dehydrogenase n=5 Tax=Bacteria TaxID=2 RepID=Q11VM0_CYTH3  ali  14  55.............................................................................................................................................DIVILAVPV-QFLESLLLEIKDYLKAEALIVDVSSVKVKPIELMLKHL-------PLTVDILGTHPLFGPGIKGLNMVVCPVRSKKMRAITHFLRNVIQLNVLERTPETHDKQMAYVQALTHFIGRSINEMD---IPDVEQK----TPAYQYLLDIKRNLGGDSDLFLTIELENPYAKKVREEFMGAL---KSLNDRLEHIKR... 245
964 3.000e-25UniRef50_A0A1B1FT94 Prephenate dehydrogenase TyrA1 n=6 Tax=Flammeovirga TaxID=59739 RepID=A0A1B1FT94_9BACT  ali  10  44...................................................................................................................................SSNLELAYWADIVVLAVPISAMS-NVMEEVFPAL-DDKYLIDVCSVKKFVIEKYEQLRSVYTEVLPK---YISMHPMFSHRIKNVVLFNYNDGAEDLEQQLKDTFLADKGVVKDVQYIKHDKLMGLVQGLNHFNVFVSAKTMARFNEDFEDIKSVASPPYRIFIVFYTRYVMQNPLYADIQMRNEYVYE------VVRIFRDEMNKLFDIIQTRDR 253
965 3.000e-25UniRef50_A0A2R6T8N8 Uncharacterized protein n=1 Tax=archaeon SCG-AAA382B04 TaxID=2137776 RepID=A0A2R6T8N8_9ARCH  ali  11  19..................................................................................................AREFRDEFDEIILFDKDRDAAKKAAEKLDVGYC-ENKGILSDSDVVVVCVPI-EACESVLRDVSSYVESDCLVMDVCSVKIDVVEVLENSFS-------DDVKRVSCHPLFGPSIEGENVVLIPVKGGCW--GVREFLESRGAFVKEMSAREHDEAMAVIQGLNHLISFTLGNVLNEVDFDVEECLTPTFKNFYSNIERIRR--QKPELYASIQLNN--AFVEEKANDFLDSFNKALDLVRE--DKKEE 253
966 3.000e-25UniRef50_A0A2V7GIZ1 Prephenate dehydrogenase/arogenate dehydrogenase family protein (Fragment) n=1 Tax=Candidatus Rokubacteria bacterium TaxID=205360  ali  17  22.....................................................................................................RAEGLAREIVAVGRRRESLEPALRDGAHITTDVAEGVAGSDFCVLATPVATLA-SLLDEVWRAAPDDAVLTDVGSTKSHIVSTAEA------LGHSRPLAFIGGHPMAGSEFKGALVILTPTASRSALARVREFWEALGARVMTLDPATHDRAVAAISHLPHLVADALVDAVLRMD...................................................................... 205
967 4.000e-25UniRef50_A0A1V5RSG1 T-protein n=2 Tax=Spirochaetes bacterium ADurb.Bin315 TaxID=1852912 RepID=A0A1V5RSG1_9SPIR  ali  14  50.......................................................................................................................................EEVLDSPTVFYCVSISAF-EEVLANSLPYLKEGAVVMDTCSVKLYPARVMK-------RLLPPTIQAIATHPMFGPGLEGLPFVMDNVAHEETWRWWVDEFTSWKMDVLMMSCDQHDREAAWSQGITHFIGRTLAEL------NLG-----STRLATKGYQTLMGVVEQTQLFYDLQRYNPYT-----KQMRMGLRG-ALVTTMEALKEQEE 247
968 4.000e-25UniRef50_A0A1F9VHK1 Uncharacterized protein n=1 Tax=Elusimicrobia bacterium RIFOXYA12_FULL_49_49 TaxID=1797954 RepID=A0A1F9VHK1_9BACT  ali  16  49.................................................................................................................................VTTDLKTGTEKADIVVICLPVN-LTAKTVKDIAPFLKPGAVITDAGSTKEEVLKGV----SSVVRRPGGKIFFVGGHPLAGSEKSGVVISGTKGVPRDKAGLVENMWKKAGAVIVRMEAAEHDRAVSATSHLPHIIAFCECL----LVNDLDRKDGRVKRLLAGSFKDMTRIADSNPAD....................................... 231
969 4.000e-25UniRef50_A0A0V0PT34 Uncharacterized protein n=9 Tax=Rhodobacteraceae TaxID=31989 RepID=A0A0V0PT34_9RHOB  ali  11  60..............................................................................................................................................VVVLAVPVPGL-GDCLRRLAPHLRPGQVVADVCSVKQGPAGLMRQIL-------PAGVEILASHPLFGPQLAGGRVVLCPVRGRGWRRIAAFLRRVLGLEIILATPEEHDRHAALTQGLTHLLAHALAGF------------QPHPRIRTRSFDLLARALAMVGADA...................................... 211
970 4.000e-25UniRef50_A0A101DI18 Prephenate dehydrogenase n=1 Tax=Desulfonauticus sp. 38_4375 TaxID=1635258 RepID=A0A101DI18_9DELT  ali  12  1..................................................................................................MEKERKKVVILGARGKMGKLFTQRVKEFDLPLEKKLLAEVKEAFLVLLCVPIKAL-DEVLEALAPCLQPPTILADICSVKVIPLQKMHKAYAGP---------VVGTHPLFGPDLKASKIALCEAREQESMSRVAEFFQQLGFETFFTTPREHDLAMAYIQGLN---FISTLTYFASLEQNL-SLDKFMTPSFKRRQEAAAKMLQEDELFTTLFEQNPYS............................. 217
971 4.000e-25UniRef50_E8R1H5 Prephenate dehydrogenase n=2 Tax=Isosphaera pallida TaxID=128 RepID=E8R1H5_ISOPI  ali  13  76..................................................................................................................................VPTLARAAAVSDLVVVCTPVDRIAANVAEALA-HGPDHLAVTDAGSVKAAILRDLRLMGETAGPRSRNDARFVAAHPLAGSELAGVEHARDPVTDPDALERVSAFWTTLGCRLVSLDPEEHDRVLALTSHLPHLIASALAGCITPRDQD------FAAGAYRDLTRVAA---ADAGLWRAILQANRAALDRALD--LFRARLDQLRAALD....... 290
972 5.000e-25UniRef50_A0A2V2UA55 Uncharacterized protein n=1 Tax=Thaumarchaeota archaeon TaxID=2026795 RepID=A0A2V2UA55_9ARCH  ali  18  43............................................................................................................................SANTTVFEDIVHCVDTADLVMVCVPISEV-PHIIQECATKMKPGAILVEISSIK--------NRSYKALKRVPNHVKPLCIHPMFGPAAPLMKIILIPVRNENELRILKELFEGSVASIIH-DAETHDRIMSIILGLTYFTNLVFASFV--SKQDYQSLKQFSGTTFRIQSLLCTSILDEPDLILALLSQN................................ 226
973 5.000e-25UniRef50_A0A2T9WL68 Chorismate mutase n=2 Tax=Archaea TaxID=2157 RepID=A0A2T9WL68_9ARCH  ali  13  90................................................................................PKRVTIVGYGGMGKALAKLLTSAGHNVVITGRNSDKAENV--AKESGCVYMPQN-EALKWGDYIILALPPEAIKGDYFFNLKTALR-GKTVMDILSVKGDNFDFLER------ISIEESFRFVSTHPLFGPQSNGEDIVVIPSKTSEDISDVISFWKSAGLNVIISDPEKHDKAMAVVQVLSHFYLLALKESYNKLAKVLGVKKEMKTVTFKDLMRIINRVSSQEDIVMEIQKNNPYAFIA.......................... 325
974 6.000e-25UniRef50_A0A2M6K8Q4 Prephenate dehydrogenase n=1 Tax=Candidatus Falkowbacteria bacterium CG11_big_fil_rev_8_21_14_0_20_39_10 TaxID=1974570 RepID=A0A2  ali  13  41....................................................................................................................KENPARAKKIGVRLT-DLKDTL-NSDIVILIAPISQ-TEKIIKEIAPQLKPGCLVMDACSVKVYPCQWLKKHL-------PKSVEIMGTHPMFGPTTKKLQIVLCPLR----IKKIRKFLKKLDLKVIITTPDDHDRQNAKTLSLVHFVGRSILGAGIGQQKIY-------TPGYEDLLRILPHTTDNWQLFYDMNNYNPYA---QVIRENFLDSCQTINKKINAFKKNQK 265
975 6.000e-25UniRef50_UPI000D6C10FD prephenate dehydrogenase n=1 Tax=Microvirga sp. 17 mud 1-3 TaxID=2082949 RepID=UPI000D6C10FD  ali  15  34............................................................................................EFSLPHLRRFFD-LRIHDSRHDLGALS------ARWNVEAVDLETAARQDIVVLAVPLRSL-RAVARAMAPHLSPGTLVVDLCSVKTEPLAILREEL-------PSGTRLVGTHPLFGPGIVGLRIAFCADDCAQSLVAARFLRRHLGLHVIRTTADEHDRQMAYVQGLTHL--------LGRVTAAMALPRLDLTTASFGHLQHMVDMVDSDELFRTIISDNPY.............................. 242
976 6.000e-25UniRef50_A0A0A1H7M9 Prephenate dehydrogenase n=3 Tax=unclassified Burkholderiales (miscellaneous) TaxID=80841 RepID=A0A0A1H7M9_9BURK  ali  18  53....................................................................................................................................SLAEAVAGADCVLLATPVGAM-PALLDALAPHLRDGAIVSDVGSTKEGIVDAARAALGA------KFARFVPAHPIAGAESHGIEVIVTPTAETDALRRIEAAWTACGAAVERMDAREHDRIFAAVSHLPHLAAFALMRAVAAGAD..................................................................... 204
977 6.000e-25UniRef50_A0A1F6PD52 Uncharacterized protein n=1 Tax=Candidatus Magasanikbacteria bacterium RIFOXYD2_FULL_41_14 TaxID=1798709 RepID=A0A1F6PD52_9BACT :  ali  13  55.....................................................................................................................................PLEQVATASMIFLCVPISEIDP-VCRELAPLLSPGTIVVDTCSVKVYPAKVMQAIL-------PKNQPLIATHPLFGPGTPGRKIVVCPLRSTVEQDQLLSILKELQLHIIETTADNHDRQMARSQSLVHLLGRVFADLDLNNQEI-------STPDYESLLR-INSFVNNDQLFFDMQCYNPYTLRQSLDNLEEKIRVE.............. 253
978 7.000e-25UniRef50_A0A1V5FI16 Prephenate dehydrogenase n=1 Tax=candidate division BRC1 bacterium ADurb.BinA292 TaxID=1852824 RepID=A0A1V5FI16_9BACT  ali  15  8..................................................................................................LAVRRQRLAHRVVGLGRSAEKLARARDLGAEFQTDPAAALAGADAVVLAIPPVQIRES-FAQIAPYLERGTFVTDVGSVKARIVEAAEANL-------PSHARFVGSHPMAGSEKTGAHHARTGRTAPEALALARALWEAVGSRVVELDPARHDRLLAGISHLPHVVAAALIQTLTRHLAPAAELGGLCGQGLRDTTRVAG---GDTEIWRQILTENAEEVLACLDQM..................... 239
979 7.000e-25UniRef50_A0A0M0BEL0 Uncharacterized protein n=1 Tax=miscellaneous Crenarchaeota group archaeon SMTZ-80 TaxID=1685135 RepID=A0A0M0BEL0_9ARCH  ali  11  23..............................................................................................GMGKLFAKIFKNYAKEVIICSRNIAKAKKVAKSLNVSAWPLEECNKADVVLVSIPI-EETYKVCKEISEKMKKGTLLIELSSVKRGIADKLSKDL------KEKGIYYLSLHPLFGPSLKGKKIVTIRSNKNIKVEKILRFFVLKKTTIIESNVEEHDKFMATIQVAHHFMYLGYLTMEKY--YDMNSMKEFATESFKRTLKTLKMIKENRDTILTIQKLNPYSEEARSRFIEGLSKIRKMDSSVELIHE... 267
980 8.000e-25UniRef50_A0A2H5ZRV0 3-hydroxyadipyl-CoA dehydrogenase n=1 Tax=bacterium HR31 TaxID=2035426 RepID=A0A2H5ZRV0_9BACT  ali  12  15........................................................AGTMGAGIAQVCATSGFSVVLYDAFAEVLPKARERIEQDTDRL-------------VQRGRLDPEARAQALQRLTAETLEALAGCDLVVEAAPEDNLKKDLFSRLAAVAPHAILATNTSSLSVAELAAVTALPQRV-------AGLHFFNPA--PVMALVEVVRAPQTAPEVVERLVAFARALGKTAIVA-KDSPGFVVNRVEGLR-VVGEGLADVDRAAREAGGFRMGPFELMDLVGID-VGYAVAQSQAFAGESRFRPHPLQRE......................... 268
981 8.000e-25UniRef50_A0A0V2F0T4 Chorismate mutase (Fragment) n=3 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A0V2F0T4_SALNE  ali  12  1...................................................................................................................................................................................................................SLRKQVVVWCDGRQPEAYQWFLEQIQVWGARLHRISAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPLYADI-------IMSSERNLALIKRYKRFGDAIGLLEQGDK 131
982 8.000e-25UniRef50_A0A1Q7MDA0 Uncharacterized protein n=5 Tax=Archaea TaxID=2157 RepID=A0A1Q7MDA0_9CREN  ali  14  109..............................................................................................GMGRFFARFASLQGAKVRLAGREISKTRTAAKEIEVEPGTILDAASSDIVILAVP-MEETVRVATETASLMTNGSLLADLSSVKTGISDRIAEKI-------PKGLEYVSLHPLFGPHLHDQTIIAVSYTAGQKWSKLARALQSGGSKVQTMSAAQHDRAMAYVQGLHQFALISLGIGLDGMGGEPK------TQSLRETEGRIANMLDNWDTIVGIQQLNP............................... 319
983 9.000e-25UniRef50_A0A0E7UKY5 3-hydroxybutyryl-CoA dehydrogenase n=108 Tax=Bacteria TaxID=2 RepID=A0A0E7UKY5_BORPT  ali  13  13........................................................AGAMGSGIAALFASKGFDVVLIDPMEGALTRAAQVIERQL-------GVYAPDAIAPAMQRIR----MDAGL-------EAACSAQLVIEAVPEKALKRDIFARLDTLCDPQAIFTNTSGLSINDIAQAVTRRD-------RFVGTHFFTPADV--IPLVEVVRNDDTSEQTVARVMDMLRAGGKRPVLVRKDIPGFIANRIQHALAREAISLLEKGVASAEDIDEVVKWS............................................................ 218
984 1.000e-24UniRef50_A0A2G6C315 Prephenate dehydrogenase n=1 Tax=Candidatus Saccharibacteria bacterium TaxID=2026720 RepID=A0A2G6C315_9BACT  ali  11  36......................................................................................................................SRQRAEQAGHRV-------VQFADVIIICVPI-SVFPQTLRQISPHLQPNSIVMDTCSVKVIPAKQMLELL-------PQNVAIIATHPLFGPGLEALTIVTHPVRTDDEHRQWDNYWASTGLRVVNATPDEHDQAISYSLGMTHFFGRIMAELLEISTVGYKALYEVMQQTNR----------DSWQLFHDMQRYNPHTKMRRQVYEAIKTIEARLDATLE....... 248
985 1.000e-24UniRef50_A0A062V1K3 3-hydroxyacyl-CoA dehydrogenase n=7 Tax=cellular organisms TaxID=131567 RepID=A0A062V1K3_9EURY  ali  17  35...........................................................................................IAHSENSLKEASQDQIKELDERVRNRITEDEKKNIRIHLTLDMKEGASNADLVIEAVPELELKRKVFANLDQICPGHTIITNTSSIRVSKIEDATNRPDRVLNT-------HFYPP--VWERPMVELMGGTKTSDETIERVRQFAHKIGLTPIIARKEITGFAFNRVWRAIHIVDNGVATYEDEDRIFTGMPIGPFGMMDMIGLDVVKDI.............................................. 248
986 1.000e-24UniRef50_E1QRV0 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein n=2 Tax=Thermoprotei TaxID=183924 RepID=E1QRV0_VULDI  ali  15  11.........................................................GTMGSGIAEVFAMNGFEVNVYDAYRDVIPRSLEGIRWSLGKLREK--GSLREDVDTVMKRIH----------VFDNLGNAARDVDLVIEAVFEPKVKHQVYRELEGYVGKDVIIANTSGIPITYLQSVLQ-------YKGRFAGFHWFNPPVL--MRLVEVIKGRDTSDETAGALMDLARRVGKEPILVRRDVRGFIANRV-----FGVLSTQAFILYMRGIYDYRAMDSALIYRLGLPM--GVFALTDFTGGIKL--------SYESRNLFEEIDRV............ 254
987 1.000e-24UniRef50_F0RJI4 Chorismate mutase n=1 Tax=Deinococcus proteolyticus (strain ATCC 35074 / DSM 20540 / JCM 6276 / NBRC 101906 / NCIMB 13154 / VKM Ac-19  ali  9  136......................................................................................................................................AELVQGAGLVLVSVPIHD-TAAVMAQLPPLPPGCL-LADLTSVKAAPMQAMLAAHSGP---------VLGLHPMFGPDVAKEVTVFCRGRGEPEVDWLLEQLRLWGLRLHAAQPEEHDRHMGLIQAMRHATAYAYGLNLSRERPQLDELLALSSPIYRLELMMVGRLFAQDPLYYDIQRQHLELIRDYHATLADVIERDDRDAFTQRFCEVRE 348
988 1.000e-24UniRef50_A0A1J4VFZ8 Uncharacterized protein n=2 Tax=unclassified Candidatus Omnitrophica TaxID=1047005 RepID=A0A1J4VFZ8_9BACT  ali  15  39..................................................................................................................KNKIAAAVKMGAIDEGTDDIRKAVALSGLIILCVPVSDIIKKILKKIAG---KTSIITDTGSTKLKIVKAAGR------------LNFIGSHPLAGSEQSGIVLILTPERCKKQLARLAEFWEKLGSKTVVMTPEKHDHMLAFSSHLPHAAAFSLMQALPNEAIDFTAGLKDSTRIALSSPDIWADIFISNAKEVIRSIRAFEISLQTLKKAVAGHNKKELVSFLKKSKDKR. 271
989 1.000e-24UniRef50_A0A1B7LAH5 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Desulfotomaculum copahuensis TaxID=1838280 RepID=A0A1B7LAH5_9FIRM  ali  12  12........................................................AGTMGRYIAQAVLEYFLRVNLIDISEKVLDSACQMIRDGLFK-------------RVESGKMSMSKVDNACLGVFLNLEEGVFDADLVIEAVSENPLKKEMFKKLDGICPPSTILTNTSGIPITSIARITNYRERV-------VGTHFYNPAHL--IPLVEVVRSDYTEKKVVEEVMSFLRSLGKKPILVNKDIPGFIGNRLQHAITREALSLLQNGVASARDIDDVVRYT............................................................ 224
990 1.000e-24UniRef50_A0A126QX53 Chorismate mutase/prephenate dehydrogenase n=1 Tax=methanogenic archaeon mixed culture ISO4-G1 TaxID=1452364 RepID=A0A126QX53_9EU  ali  12  137..........................................................................................................................................ADCEIVVISVP-MHMTLDVYKELDKYCYQEATIFDLTSLKTPLIDFLTSISQRRK--------VCSVHPMFGPSAKGRNLIICHCGCGKSVRETKEIFDDRGLNIRVMDIKDHDKYMSYVLGLTHAVNIALFSVLERSGYPFEDLKTVASTTFNKGLDTNISVASEDPLYYEIQHLNADLFSQTVEDLKKNSLSDDPEGFITMMNAGKR 346
991 1.000e-24UniRef50_A0A1F9UML8 Uncharacterized protein n=1 Tax=Elusimicrobia bacterium RIFCSPLOWO2_01_FULL_59_12 TaxID=1797946 RepID=A0A1F9UML8_9BACT  ali  21  6.........................................................................................................................................VASADIVVICSPLDAIIP-LFKRIVPFLKPGAIVTDAGSVKEPILRA------AARVKRPASVHFMGGHPLAGSHRTGVEVVLVPG-SRTALSPLKALWRVAGAKTLVLTAKEHDRAVALISHLPHALAHALV............................................................................. 141
992 1.000e-24UniRef50_A0A1Q7SWA6 Prephenate dehydrogenase (Fragment) n=1 Tax=Ktedonobacter sp. 13_1_20CM_4_53_7 TaxID=1805226 RepID=A0A1Q7SWA6_9CHLR  ali  15  1.........................................................................................................................................VRGAELVILATPVGTM-RSLLQEIASSVTPGTVVTDVASTKSQVISWAEEYL-------PSSVAFVGGHPMTGKEVSGVQAAPTAHTPSIAITKVSALIEALGARVRFLEPAEHDGQVAGVSHLPFIASIAMMNTVAEGTGWVDASM-----LAAGGFRDITRLAANPEMYRDICLTNSESLTRWLNE...................... 189
993 1.000e-24UniRef50_A0A177L0D0 3-hydroxybutyryl-CoA dehydrogenase n=3 Tax=Bacillaceae TaxID=186817 RepID=A0A177L0D0_9BACI  ali  13  1...........................................................MGTDIAQLIVSQHVDVILVDTNKEALNRAKEKMRKQLQFLHE--HHFIEEAADSIIARIHFSE-----------QMQDVKHCWLVIEAVPEKELKQQIFKELEAVCHSDVIFTNTSGITVSSIAKELTYPERL-------VGMHFFMPASI--IPLVEVIKGNDASEPVLEQVMHFLKKIGKQPVLIQKEVPGFIGNRIQHAIAREAISLLESGVASAEDIDTVVRYS............................................................ 208
994 1.000e-24UniRef50_A0A133VDQ7 Uncharacterized protein (Fragment) n=2 Tax=Archaea TaxID=2157 RepID=A0A133VDQ7_9EURY  ali  14  7..............................................................................................................................NIETTTDQDKGVSNADLVIEAAPEMELKKEIFSAVDKASPKGAILSNTSSLSIGEMAEATNR-------GEKFAGLHFFNPPV--RMPLVEIIRHEGTSDETAETCVDYAESLDKTPVICRKDVPGFIVNRILGPVYREEASIEEVDAAAKFKAGLPMGLFELADFTGLDI.................................................. 178
995 2.000e-24UniRef50_C8WZE5 Prephenate dehydrogenase n=3 Tax=Desulfohalobiaceae TaxID=213117 RepID=C8WZE5_DESRD  ali  14  6.....................................................................................................AIQTILFIGGNGAMARFLQPRLEEAGYAVREQLRTAASGVDLVILAVPVPAV-EEVLAKVVPFVPARAILADICSVKDAPLRHMLHYFSG---------DVVGTHPLFGPAATPLRTVLVPGRGANALERVRDVFERAGLVCFESTAEAHDRSVALLQGLNFVTSVAYL----ACSADQEAVATFMTPSFTRRLEAAKKLLEDSPLFTALFEANPYSAVRQFRSYLNLAAAGDMDILVE....... 244
996 2.000e-24UniRef50_A0A1Z8PSB2 Uncharacterized protein n=11 Tax=Bacteria TaxID=2 RepID=A0A1Z8PSB2_9BACT  ali  15  39..........................................................................................................SRSVVLWGRNSARVEEIRXSGWPHVTDLEEAVTDADLIILAVPV-DCLEDLGRRILTILRKGVCVTDVGSVKAWPHQSLGQLMXS------EGICFIGSHPMAGSERTGCILTXEHQXPEESVTQLATFWEDLGATXTVMDAEEHDRLVGRISHLPHVLSTVCALTALERVEDGGQGLRDTSRVAAGDPAMWAEILLQNR----SQILDPREAASTLSQMAEDLTKQDRAAILKAL..... 282
997 2.000e-24UniRef50_A0A2E4RML3 Uncharacterized protein (Fragment) n=1 Tax=Flammeovirgaceae bacterium TaxID=2026740 RepID=A0A2E4RML3_9BACT  ali  8  42.......................................................................................................................................DLINKSEWIILCVPIDK-TLEVFDGIKNKIRKDQVFSDFTSVKS------------IFDDNTYDFEFISCHPLFGPNIIGQNIVTIPVSKGSLYGHIKSIYNKIGLKITEMSFEEHDKYMSLIQGMTHFSHVCFTTAMKKLDLDIDKVMDICSPIYQSNISFSSRITGGDELYTNIIMDNP............................... 213
998 2.000e-24UniRef50_UPI000DD6B660 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Microvirga sp. c27j1 TaxID=2249811 RepID=UPI000DD6B660  ali  17  78...........................................................................................................................KSQGVRVT-DLATAAQK-DIVLLAVAPRDL-RDVARKIAPHLKIGSLVIDVCSIKTKPLAILAEEL-------PAHAEIVGTHPLFGPGIEGLTIAVCSSGSPRGRLVTRFLRKKLGLRVVPTTPERHDEEMAYVQGLTHLLSRIVLAMDVPAIEHTTATFDHLMRMVGMVRD------DSDEIFRAITEENPFAAE........................... 263
999 2.000e-24UniRef50_A0A2N8HL04 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=26 Tax=Akkermansia TaxID=239934 RepID=A0A2N8HL04_9BACT  ali  13  59..................................................................................................VRKQLPHVHVRLWGRREEPLEYARSSGAAHAASTRLEEVVEGADLVVLATPVG-VMSRLVSGMLPLLKPGVLVTDVGSVKGCVHQSVGSAL------TETGVAFIGSHPMAGSEKQGMEHASGELTNDEHVHELQRFWERVGCHCIRMKAADHDSSVARISHIPH-ALSALCVHTALDGGDVK----LLGLVSAGGFRDTTRVMGEPSMWAEILTENAPAVLDRLDE...................... 287
1000 2.000e-24UniRef50_T0XQH2 Prephenate dehydrogenase n=2 Tax=Leptospirillum TaxID=179 RepID=T0XQH2_9BACT  ali  18  57................................................................................................................................RFADSNESAVAGVDLAVIAVP-PQAVPRVWGEIVGPLPPSAIVTDLSSVKGSLYELYRTSFSALLPL------YTSSHPMAGSERTGITVFLTPFGSEKTLLPLVRLWQALGANTVPVSPADHDGIVAHISHLPHALSYCLLNLAEKVRQENRYPGFDWKTQKGGSFSDILRIASSPELWADIFFQNRTAILDAIESFD.................... 261
1001 2.000e-24UniRef50_A0A2N2LMK3 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=3 Tax=unclassified Chloroflexi (miscellaneous) TaxID=189774 Rep  ali  14  107.................................................................................................RLRQTLKDVEVVGYDRYPDVARVAERRGAIQRVFHTPEDAAKDADVVILAAPILAI-RELLKDIAGVVSPDAVITDTGSTKVEVMRWAAELLPGHH-------GFVGGHPMFGPAAADPVVLPPPTASEHAVATVTNLVESMGARLMFMDAEEHDAYTAAISHMPMMAAIALFSMERAS....................................................................... 290
1002 2.000e-24UniRef50_A0A2D7PII6 Uncharacterized protein n=4 Tax=Bacteria TaxID=2 RepID=A0A2D7PII6_9DELT  ali  13  59......................................................................................................................................EEVVRGADLVIVCSPIG-VMAQLLERASPGFRPDALVTDVGSVKGPLADQI-------PAILPEGVEYIGSHPMAGSHERGAECVLTPRVDTKSLARLSDFWQELGARVVIRTPEEHDVDVAWVSHVPHVVAFAFAHAFQEASELAGSGFRDFTRIGRSDSEMWSEILNANPLQAFGQSL--AQLGAALEAGEVETHEEFLAQARQALER... 281
1003 2.000e-24UniRef50_A0A2E9EWG4 Uncharacterized protein n=6 Tax=PVC group TaxID=1783257 RepID=A0A2E9EWG4_9BACT  ali  14  30..................................................................................................LASKKFELADRISLWVRRPAAVEELMDANIAVSNDFNEVIPDSDLIVLATPVGAV-GEILSKIIPIAKSNAXITDLCSVKXCVVSLVDKLLS---NSNREDLNFVGAHPMAGAEVGGCAITPGITSSENSEAVVYKFWXELGCRCIKIDASMHDEMVAKVSHLPHLISSALAIT---SLDDKSDDVKLAGPGIKGMTRVA---LGSPDMWAEILLHNKDSVQKVLSE...................... 261
1004 2.000e-24UniRef50_A0A2N5ZPT6 Uncharacterized protein n=1 Tax=Candidatus Parcubacteria bacterium TaxID=2053309 RepID=A0A2N5ZPT6_9BACT  ali  11  41.......................................................................................................................IKAAKIIGVNLI--NPKELNNADFIFLTVPISR-TEETIKNISNKLKEGSLVMDACSVKTLPCKWLNKYL-------PKNVQILGTHPMFGPNTKNMQIVLCPQRVEKTYKQIKDVFMDLGLKIIETTPSNHDKQNARTLSFVHFLGRSLWDAGFREQEIY-------TPGYKDILRIFGHTTDDWRLFFDMNKFNPYS............................. 236
1005 2.000e-24UniRef50_A0A151BN87 Prephenate dehydrogenase (TyrA2) n=1 Tax=Candidatus Bathyarchaeota archaeon B63 TaxID=1779372 RepID=A0A151BN87_9ARCH  ali  16  20..................................................................................................FHQRGDEVIISDIDEEKARIFAD---NLGIRMARNNMEAAESAELIMVCTPI-ETASTVINDLLGGIRGSAVLTEISSVKSPVMPVMRKAVE-------KGLNVLSVHPLFGPGVKDVRIAVVPVEDEASIGLARRIFPDM--RILSVDFERHDYVMALTLSLTHFMNMAFASVLAD--EDLRELKSLGGTTFRMQMMLIGMMTEDPGLFTSIQMCNPYTI............................ 230
1006 2.000e-24UniRef50_A0A2B4QY30 Putative 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Stylophora pistillata TaxID=50429 RepID=A0A2B4QY30_STYPI  ali  14  10........................................................SGQMGRGIAQVAATSGYFVILSDVSEEALDLAQKEIQKSLSKLHEKGKISESPDQIFSRLKM-ETTVESLGV------------CDLVIEAVPEEDLKGQVYEKLAPYLKENAILASNTS------YIGISGLGESSGHPHRFLGVHFMNP--VPLMPLVEIIVGDKTEQDVCDVAYRFVESLGKT-SVTSRDRPGFIINRILMPMINEAIFVFSEGVATVEDIDKGMELGTPMGPLKLDFIERTAETFPKTFEEAMAELENLVRRLESGDI-----PLDQSIQAYERGR. 277
1007 2.000e-24UniRef50_A0A0B1TT76 Putative 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Oesophagostomum dentatum TaxID=61180 RepID=A0A0B1TT76_OESDE  ali  16  2.......................................................................................AKEQLRKGLA--RSAAKKRGEDPSGKDMANISMLEAQMDRLQLCSDIRSAVLNADFVIEAVVENHIKEDVFIEAQEHCSPYALVTNTSSI-------CLTDLCSCIRDHSRFAGLHFFNP--VPVMKLVEVISTPDTSKETHAKLLDFCMSLGKRPVSC-KDTPGFIVNRLLVPYLLDSIRMLERGDASKEDIDAPMGPLHLCDYVGLDTIANVMSEW.......................................... 218
1008 2.000e-24UniRef50_A0A2V6SCA6 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Candidatus Rokubacteria bacterium TaxID=2053607 RepID=A0A  ali  12  29.........................................................................................................LCDTVVGVGRSRASLEPALAAGAVATDDLADGVRDADLVVLCAPVGAL-PGLVRAAWPHLGPETLFTDTGSVKRGVVAAAH------GCSARPGVTFVGSHPMAGSERSGALVTETAATDPGAVAEVAAFWESLGSHVRTVSVDAHDRGVAVISHLVH---------LAAYGLVAAAAGDALSLAARGFVDTTRIAASAEALWTDIFRENRPALLEAID....................... 246
1009 3.000e-24UniRef50_A0A2E1RGR5 Prephenate dehydrogenase n=2 Tax=Oligoflexia TaxID=1553900 RepID=A0A2E1RGR5_9PROT  ali  14  33...................................................................................................................................DTDLSAIKNARIVILAVPISSM-EEICQQISPYISTETIVIDVCSVKEYPVEIMKK-------TLPPKTKILGTHPMFGPDLFGTKLVLCESVSADFLNKVKAYLENQGMRLIEVSPTEHDQAIANTLLLSHFIGNGLLDFGAKEELI.................................................................... 178
1010 3.000e-24UniRef50_A0A2U3CGG2 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=Candidatus Heimdallarchaeota archaeon B3-JM-08 TaxID=2012493 RepID=A0A2U3CGG2_9ARCH  ali  17  14........................................................AGDMGHGIAQVCLMTGYTVSMYDIKDEFVEKGKSRIEWSLNKLAEKA-RISEKDRDTYLGKLT----------ISTNMEEVVKNADLCVEAAPENDLKKKIFGDLDKYAPKHAILANTSNMSITEIGEATKRPD-------KVAGLHYFNPPV--MMQLIEIIKGEKTSDETINVLIDLAKKSTKNPV-VSKDHPGFIVNRINAITMLLIHTMLDEYKAEEIDAAAMMMGMRMGPYELMDFVGLDVAYHSMNYLADRLDKD.............................. 257
1011 3.000e-24UniRef50_A0A2N0L6S4 Uncharacterized protein n=1 Tax=SAR202 cluster bacterium Io17-Chloro-G3 TaxID=1926612 RepID=A0A2N0L6S4_9CHLR  ali  12  107.............................................................................................................................................DTVMLGVPEDAM-ETTAQALLPHLKTGTNVFDICSTKRLALPAMLKH-------APPGVSVLGTHPLFGPAVSDLVMVPTGQTDETFYRWYSNVVRSFGAVVEEMIPQNHDLYMLFIQTLTHFSYLVFGRTLAQMGFDLAESFQLSTPPYGIMAAFTARLIGGNPLYAQIQADDVRALFVKAAEELATQFSGDREGIQSAIQEV.. 315
1012 1.000e-10UniRef50_A0A0G4NER6 Uncharacterized protein n=3 Tax=Verticillium longisporum TaxID=100787 RepID=A0A0G4NER6_9PEZI  ali  13  262..........................................................................................................................................................................................................VPMGPLQLADFIGLDTISGLQTSQDTLDTAIEFCRAMGK-ITSVSADSPGFLANRILMPYINEAVICLETDAIMKNGTNVPMGPLQLADFIGLDTCLAIMKVLHEETGDSKYRPSVLLRKMVDAGWLGKK............... 398
1013 2.000e-07UniRef50_A0A1F6P4V0 Uncharacterized protein (Fragment) n=1 Tax=Candidatus Magasanikbacteria bacterium RIFOXYC2_FULL_39_8 TaxID=1798702 RepID=A0A1F6P4  ali  18  43.........................................................................................................................................VLNVDVLFLLVPISEIK-NVCKEITDKLDPKTIVVDACSVKV-------KPVEDMLFELRHTQPIIATHPLFGPGIEGQKIVVSPVRTEEQLNMFEKMFEKMKFKIIHATPEEHDRQMARSQALVHFLGRGLAE............................................................................ 175
1014 3.000e-07UniRef50_A0A161KJ50 Prephenate and/or arogenate dehydrogenase n=4 Tax=Thermococcaceae TaxID=2259 RepID=A0A161KJ50_9EURY  ali  19  37...................................................................................................................................SSLRELYEWSDVIILATSMEKIRDQLLKEIAQENPKGTVLFDIATFKSEIIELYVDF--------PKSVKVASVHPMFGPGVEGERFIIVPVPGEDDSRMVADLIRKFGGNVSFLPAEKHDYIMGYVIGVLGLAYLGLDEFITYGKAVLNDSPEFIREVLKNSWKQIVEFL------GMVLSVNPGQLK........................... 234
1015 3.000e-07UniRef50_A0A2W6A3L0 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=candidate division AD3 bacterium TaxID=2052315 RepID=A0A2W6A3L0_9BACT  ali  17  75...............................................................................................................................VSTTNDLAEALTGAALVIESVAEDRETKRVMEAIGRHAAADAIIGTNSSTLPSSLFAALVPNDERL------LNIHFMNPALV--MPLVEVVRGAHTSDATVQAAMSFVRVIGKAPVLVERETFGFVANRILALVENGFVSISDCDQAVRDGLGWPMGPFAIADLVGLDVVEAILEEGHGQTGEERWTPPALLR.......................... 269
1016 4.000e-07UniRef50_A0A1W2AW32 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=Papillibacter cinnamivorans DSM 12816 TaxID=1122930 RepID=A0A1W2AW32_9FIRM  ali  18  71...............................................................................................................................AKYTSDVKEAVKDAEFIQENGPENAIKQSIIKTIEEYCKPDAIISSTSGLLVSDIAAYAKHPERI-------VGGHPYNPVHL--IPLVELVKGKHTSQEALDKAVAFYREMGKEPVVLNKECPGFICNRIQVAVELVLRGVCTVEDVDKAVVFGP................................................................ 224
1017 1.000e-06UniRef50_A0A2N6ST16 3-hydroxyacyl-CoA dehydrogenase n=22 Tax=Firmicutes TaxID=1239 RepID=A0A2N6ST16_FINMA  ali  20  35.....................................................................................NRSLESEEKTKKIIEKYVDELIEKKVVAEDKETILSR-----ISYTTNEQEAIEFADIVEECIPENDVKKEFVKVFEKYAKPDAVLCSATSLLVTKIAEDAERPERIF----------GAHPYNPPHLIPLIEISQGEKSDETANALRELFVKLGKKPIIIRNEVPGFIANRLQAVVMREMMDLVDKGVVSMEDCETALTFAIRWAIMGPGQIFELGGEHGLQGLLDHIGPSMLEDAATWTKFTDDIK.............. 276
1018 1.000e-06UniRef50_X1FL20 Uncharacterized protein (Fragment) n=1 Tax=marine sediment metagenome TaxID=412755 RepID=X1FL20_9ZZZZ  ali  20  37.................................................................................DEFVEKGWNKIDEGLKKLETK--------GKLPGGKTAAEFI--ANCKKSTDLASAVKDADIVIEAVEKMDIKQQVFKTCGENAPPHCILANTSTMSITDIGKESGRPD-------KCIGMHFFNP--VPLMRLIEVIYSEHSSDESISKGMEFAKSLRGERYIAKVDRPGFICNRVTA....................................................................................... 203
1019 2.000e-06UniRef50_A0A1H6G7W6 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=Natronorubrum sediminis TaxID=640943 RepID=A0A1H6G7W6_9EURY  ali  19  70...............................................................................................................................LETTTSDEEAYGDADLIVEAVPEDDLKRTVFESIDDHAPERTILTNTSTLPITEIASATDRPNAV-------VGMHFSNP--VQLMEIVEVIRGKATDDDVFEAIQEISTEIEKTPVLVEKDIPGFLINRINL....................................................................................... 195
1020 2.000e-06UniRef50_A0A0N0H5W4 3-hydroxybutyryl-CoA dehydrogenase (Fragment) n=1 Tax=Streptomyces sp. NRRL F-6602 TaxID=1609099 RepID=A0A0N0H5W4_9ACTN  ali  19  55..................................................................................................................KGKLSAEDAEALGRITTTTDLEGAADADIVVEAVEQLDVKHEIFRTLDKLVREDTVLANTSAIPITKIAAVTDRPERV-------VGAHFFSP--VPMMQLCELVRGYKTSDETLARTREFAESTGKTCIVVNRDVAGFVTAR--LITALVVEA............................................................................... 200
1021 2.000e-06UniRef50_X1UPK9 Uncharacterized protein (Fragment) n=1 Tax=marine sediment metagenome TaxID=412755 RepID=X1UPK9_9ZZZZ  ali  17  53...............................................................................................................................IKGTTDISQAAKNADFVIESVAENDIKKEVFKKLDENAPANAILANSSQLNITEMASATNRPD-------KVLGMHFSNPVGV--MKLVEVVRGTLTSDETVDLVCAFSKKLGKEPVVCKDFSFGFVANRA......................................................................................... 176
1022 3.000e-06UniRef50_A0A2M7V6U7 Uncharacterized protein n=1 Tax=Candidatus Magasanikbacteria bacterium CG_4_10_14_0_2_um_filter_37_12 TaxID=1974637 RepID=A0A2M7V  ali  14  41.........................................................................................................................................VLGSDVLFLLVPISEI-ENICKEIADKLDEKTIVVDACSVKMYPVEVMKKVLKA-------DQPIMATHPLFGPGLVGQKIVVCPVQTEDQFQQCEEILTKLKLEIIHTIPEDHDRQMARSQALVHFFGRGLAELKLENQEI.................................................................... 181
1023 3.000e-06UniRef50_UPI0009BBE07C 3-hydroxyacyl-CoA dehydrogenase family protein n=1 Tax=Varibaculum timonense TaxID=1964383 RepID=UPI0009BBE07C  ali  14  70..............................................................................................................................NLEAFTDLQSAVKDADLVIESVSENELKKNIFKSLDEYCRKDTVLADTSSLNIYEFLEVSNPERVLIT--------HFFNPAYV--MPLVEIVRGPETSDEVVKRVYDMLKESGKSPAVLNKAVPGFIVNRLSVAIAR................................................................................... 199
1024 4.000e-06UniRef50_A0A2D6SPH4 Prephenate dehydrogenase n=1 Tax=Candidatus Woesearchaeota archaeon TaxID=2026803 RepID=A0A2D6SPH4_9ARCH  ali  13  80......................................................................................................................................LEEVCKKDVVVLAVPISEF-EKVLVQIKDILKENSTVIDVCSVKEYPVKLMNEIL-------PKKTQILATHPLFGPDSVKDSLDGKKVVIDTMYNKIKDYLKKKNLIILEITPEEHDKEIAKSLLLTHFIGRALIDLKKSNLDI.................................................................... 222
1025 4.000e-06UniRef50_A0A1M4UB46 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Desulfacinum infernum DSM 9756 TaxID=1121391 RepID=A0A1M4UB46_9DELT  ali  15  83........................................................................................................................................AVADADLVVEAVTESAVKVRVFEEVERHVPAAAVLCNTSAISISEIARCLQHPQ-------RFLGTHFWNPPHV--VPCVEVIKGEETSEQVFEGVVELMRRLGKEPVRVLKDVPGFLGNRLQ........................................................................................ 198
1026 4.000e-06UniRef50_A0A2E9NU79 3-hydroxyacyl-CoA dehydrogenase n=4 Tax=Bacteria TaxID=2 RepID=A0A2E9NU79_9GAMM  ali  17  58..............................................................................................................................GFCFTTDAAKAVKGAQVIQESAPENLALKQELYRIIESAPKSTILSSTSGLTLDMLQIGFSDPSRILI----------AHPFNPPHLPLVEVLGNELTAPDLIEWALSFYEGLGKVPIELKKSVPGHVANRIQAVLHLAKEGVASLSDIDKAIANGPGLRWAIYGPNQLFSLAA--GAKGLEGFIDHLGP............................... 243
1027 4.000e-06UniRef50_A0A212K0S6 Putative Prephenate dehydrogenase n=1 Tax=uncultured delta proteobacterium TaxID=34034 RepID=A0A212K0S6_9DELT  ali  18  47....................................................................................................................................DLANGIPLGDVVLLCVP-APAMPETLDRIRPYLREGQILSDVCSVKINPMRWMEERFDGP---------VVGTHPLFGPETGGKVALVRGKATDEAMDRVASLFREIGCVPFTATAAEHDSAVGITQSL-HFALSAA--YFSAAAR..................................................................... 183
1028 5.000e-06UniRef50_U4VAN8 Cyclohexadienyl dehydrogenase (Fragment) n=1 Tax=Ochrobactrum intermedium 229E TaxID=1337887 RepID=U4VAN8_9RHIZ  ali  24  29........................................................................................................KLADHIAIATRSSETLKRAEELGLGYATDSAEAVKDADLVIVSVPVGS-SGTVARQIAANLKPGAIVTDVGSTKASVIAQMQPEL-------PDTVHFIPGHPLAGTEYSGPDAGFAELFTNRW....................................................................................................................... 146
1029 6.000e-06UniRef50_Q5K939 Prephenate dehydrogenase, putative n=148 Tax=Dikarya TaxID=451864 RepID=Q5K939_CRYNJ  ali  14  60.....................................................................................................................................NGHAVSRLSTFIIYSVEAAALPAVVREYGPSTRVGAVVAGQTSVKAP-------EREAFERWLPEDVGITSVHSLHGPSTEGQPLIIIHHRGEENVKMVEDVFRSFKSRYVHLSYEEHDKVTANTQAVTHAAFLSMGTAWQKSSSYPWETTRYVSGIEVIKVNITLRIYSKWHVYAGLALLNPSA............................. 241
1030 6.000e-06UniRef50_A0A2H9LBP9 Uncharacterized protein n=4 Tax=unclassified Hadesarchaea TaxID=1775753 RepID=A0A2H9LBP9_9EURY  ali  15  41...........................................................................................................................KELNVRAETREK-AVAEADVVLVAVPIA-VTPEFIKSLAKQMKKGALLADIASVKSDVVDAM--------KKLDADLELVSLHPLFGPGVKGKDFVAVPVKPRKRXXXXXXXXXXXXXXXXXXXXXEHDRMMAIVQCMTHFV---LISYLAALKSMGAERIKLVGTPMFATLQDFAKAIGNSELYGELQVSNKHAKLA.......................... 230
1031 7.000e-06UniRef50_T0SSK3 Prephenate dehydrogenase n=9 Tax=Bacteriovoracales TaxID=2024979 RepID=T0SSK3_9PROT  ali  12  40...............................................................................................................................LRATASTLKEVCECDAIIPFVPISAF-ESCIKEISPLLKDGALVIDVCSVKEIPVEIMQKNL-------PQSVQILATHPMFGPDSASKIVISKIRINDDLYDKISSYLKTNGLKVVEVTPEEHDRQIAKSLNLAHLIGRVLIDF........................................................................... 182
1032 7.000e-06UniRef50_A0A0G1N203 Arogenate dehydrogenase 2 n=18 Tax=root TaxID=1 RepID=A0A0G1N203_9BACT  ali  15  36.......................................................................................................................FTHTELAKNTVTAKDLSAVYKSDVVFFAVPISAF-EQVINSHKKYFRDNHVLIDVLSVKQHPAKIFHKY------LKDSKTQALLTHPMFGPGFKGLPMILDKYKTDSTYGFWKEYFESKKLRVIEMTARQHDEIAANTQGLTHFILLDTYGFQSSSIDSLGTKK............................................................... 201
1033 7.000e-06UniRef50_X1GTW8 Uncharacterized protein (Fragment) n=1 Tax=marine sediment metagenome TaxID=412755 RepID=X1GTW8_9ZZZZ  ali  21  60..............................................................................................................................EVSFHNNLSEAVADADLIIEAVPKLELKKDVFSQIDKAAPPHAIITNSSSIPVSRIEDAVERKE-------KVLNIHFYMPNT---TPMVDIMRGSQTSDDTFKKGKNWIESLELTPLEVKKECLGFVFNRI......................................................................................... 183
1034 8.000e-06UniRef50_A0A2E9P382 3-hydroxyacyl-CoA dehydrogenase n=5 Tax=Gammaproteobacteria TaxID=1236 RepID=A0A2E9P382_9GAMM  ali  17  33.................................................................................................EIREFVSN--SEAPLRALGYSHAGSLTD--FCFTTDAVKAVEGAQVVQESAPENALKKQLYRLIEPVLPKSLVLSSTSGLTLEMLQTSFSDPSRILI----------AHPFNPPHLPLVEVLGNELTAPDHIRWTLSFYECLGKVPIELKKSIPGHVANRLQAVLHLAKEGVASLSDIDKAIVNGPGLRWAICGPNQLFSLAA--GAEGLEGFIDHLGP............................... 243
1035 9.000e-06UniRef50_L9VLB6 3-hydroxyacyl-CoA dehydrogenase n=4 Tax=Halobacteria TaxID=183963 RepID=L9VLB6_9EURY  ali  19  43.............................................................................................DVLATALEKINESLTKLGENPDTILN-------RIETTTSDEEAYGDADLVVEAVPEKENIFGTIDELAPD--RAILATNTSTLPITEIASATDRPGDV-------VGMHFSNP--VQLMEIVEVIRGEETRDDVFEAAQEISEEIGKIPVLVEKDIPGFLINRINL....................................................................................... 195
1036 1.000e-05UniRef50_A0A0F8VN16 Putative 3-hydroxybutyryl-CoA dehydrogenase n=12 Tax=root TaxID=1 RepID=A0A0F8VN16_9ARCH  ali  21  61.................................................................................................................PEGSTAASLMEKC--KKSTNIASAVKDADIMIEAVEKMDVKKQVFKTAGDNAPSHCVLANTSTMSITEMSKDSGRPD-------KCIGMHFFNP--VPLMRLIEVIYSDHSSDESVNIGIEFAESLRGKRYVAKVDKPGFICNRVTA....................................................................................... 203
1037 1.000e-05UniRef50_A0A2E4H7P2 Uncharacterized protein n=6 Tax=Chloroflexi TaxID=200795 RepID=A0A2E4H7P2_9CHLR  ali  16  21..................................................................................................MKRKLNNTEIIISSGDRGVMSAVSKMNAANETVSNLRSAVEGAQLVVLDLPIGEMR-EILEAIGPVLDEGAVVTDTCATKTPVL----EWAESYIRSDVDFVGGHPL-PKRLPNTARYTVTPGKNADESSVRTVVGLIEALGSKPLFLDPAEHDSYAA........................................................................................... 183
1038 1.000e-05UniRef50_A0A0P1BNU1 Prephenate dehydrogenase (NADP ) n=2 Tax=Ceraceosorus TaxID=401624 RepID=A0A0P1BNU1_9BASI  ali  13  130.............................................................................................................................................DFILISVP-THLTSTIVKQVAPHLKHAATICGQTSVPEIAAFEQHVHGTANGGAGRTDVGLVSCHSMHGPGLRGQSIVLIRHATDLQFSNLEFIAGALGSRISCMDYTSHDRTVANTQVLTHTILLSM.............................................................................. 261
1039 2.000e-05UniRef50_A0A2E5ZJK1 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Acidimicrobiaceae bacterium TaxID=2024894 RepID=A0A2E5ZJK1_9ACTN  ali  18  70..................................................................................................................................TTDLNEAVGEADVVIEAVPEPDLKRNLFATLRSSAPEGALLANTSTLSITDLAAAADN-------SPRVIGMHFFNPAH--RMALVEVIISPTTDEKSLDDAVTLCRQFGKEPVIV..................................................................................................... 178
1040 2.000e-05UniRef50_A0A267MHR8 L-carnitine dehydrogenase n=2 Tax=Bacteria TaxID=2 RepID=A0A267MHR8_9CLOT  ali  20  43.......................................................................................AEEALREVIANAEQALQKIVP-VPEEKKGKLIFTK----------DIEEAVKNADYIQESVPEVEIKIPVLKEISKYAKPNAIITSTSGLLPTRLQSEMVNPERLVVA-------HPFNPVYL--LPLVEVVGGEATSEEAITTVMEFYKMIGMKPLKVRVEIDGFIADR.......................................................................................... 194
1041 2.000e-05UniRef50_A0A1C8ZSM4 Chorismate mutase n=1 Tax=Sulfolobus sp. A20 TaxID=1891280 RepID=A0A1C8ZSM4_9CREN  ali  17  138.................................................................................................................................VSMNPLEATGWGEIFILAIP-----PDVIANLSDFIGKNKILMDISSSKSIIFKYLEE------FSKKAKFKFVSTHPLFGPVGERIVIIPSENSTKDDIVRVEKLWRDAGLVPVITDVETHEKAMAIVQVLSHYYLLGLSDSISLVTKELNVDISFHTTNFREIFKVLSRVNEIKDIILEIQRQNPYA............................. 323
1042 2.000e-05UniRef50_A0A150MXT8 3-hydroxybutyryl-CoA dehydrogenase n=365 Tax=Bacteria TaxID=2 RepID=A0A150MXT8_9BACI  ali  17  66...........................................................................................................................AEARLSYSLDLASAVRDADLVIEAVPKLERKKQVFETMDAHAPASCFATNTSTMSPTEIGSFTKRPERV-------IAMHFFNP--VHKMKLVEIIRGLETSDETAQVAKEVAKRMGKETVVVN-EFPGFVTSRISALVG------NEAFYMLQEGVGTPEE-IDKAIKLGLNFPMGPFELADLVGLDTRLN................................ 242
1043 2.000e-05UniRef50_B8FBX3 3-Hydroxybutyryl-CoA dehydrogenase (NAD-binding) n=8 Tax=root TaxID=1 RepID=B8FBX3_DESAA  ali  17  72.............................................................................................................................ARISATTDTAEAVRDAQIVIEAVPIMDLKKSVFSEVANAADDAILATNTSTMSITEISKAVNNPA-------RFAGLHFFNP--VNRMKPVEIIKGAETSNATADILFKFTEAIKKIPVVVLKDSPGFIFNRINAPNQTVLSAILDEGKIKPDELDTAMKMV............................................................ 226
1044 2.000e-05UniRef50_A0A2H0Q230 Prephenate dehydrogenase n=3 Tax=Oligoflexia TaxID=1553900 RepID=A0A2H0Q230_9PROT  ali  12  35........................................................................................................................KEAKELGVQ--TGTLDEVCQCPIVIPFVPISEF-ENLMIQIKDKLNPKSLLVDVCSVKELPVNAMLKHL-------PENIQILATHPMFGPDSAGHKIVLCPVRIEDKLNDIKRYLNGHGLKVIETTAEEHDRQISHSLVLAHFIGRTLMDTGAERQEI.................................................................... 189
1045 2.000e-05UniRef50_A0A0U3NUC0 Uncharacterized protein n=16 Tax=Bacillaceae TaxID=186817 RepID=A0A0U3NUC0_9BACI  ali  17  67.............................................................................................................................ARITYTTDLHEAIQNADFILESIPEVLETKLETYEIIESVEDTIISSNTSTFPLKELTQNAKHPERFIIT-------HFFNPPQL--VPIVEIVKDDNTNEDTINATYDILKEIGKSPVVLKKEITGFIVNRVQV....................................................................................... 194
1046 2.000e-05UniRef50_L0ABJ1 3-hydroxyacyl-CoA dehydrogenase n=13 Tax=Archaea TaxID=2157 RepID=L0ABJ1_CALLD  ali  21  79.......................................................................................................................................EAVKDADLVIEAVPENDLKKKVFSEVEKFVRKETIIANTSNIRITDIAK-------DLKYRDRVAGLHFFNPPVL--MKLVEVIKAEETSDEVIDVLVDLVKKIGKYPLKVMKDTPGFVVNRINAPESLLF................................................................................. 202
1047 3.000e-05UniRef50_A0A2G9NDC0 Uncharacterized protein n=1 Tax=Candidatus Pacearchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_32_14 TaxID=1974441 RepID=A0A2G9N  ali  15  35........................................................................................................................EEAEQIGVEFGS--LEEVLKQKIIILSV-EMENLRDTLHSIKDKISPGTLVLDVCSLKLFSSKLMEDLL-------PKNIEIIGTHPLFGPQSAKDLIEGMKIARSNKIDDVKIFCESLGLDVIICSPEEHDRQMAVSQSLTHFI.................................................................................. 173
1048 3.000e-05UniRef50_A0A1F4EH13 3-hydroxyacyl-CoA dehydrogenase n=11 Tax=Bacteria TaxID=2 RepID=A0A1F4EH13_9PROT  ali  19  69...............................................................................................................................LKFSSDLAGAARDADIVIEFDPKAEL-FRRLDALCG--PEAILATNSSNIRGSRLAEVTQRPQRVL-------NLHFFNPALV--MELVEVVAHPLVSEEALRSSLEFCRRIRKTPVVLRKEIPGFIVNRIRALTREAVSLYEEGYASAEDILAVVKGLGHPMGPLRLLDMAGI.............................................. 237
1049 3.000e-05UniRef50_A0A2P6VWN7 Uncharacterized protein n=1 Tax=Thermoplasmatales archaeon SW_10_69_26 TaxID=1919232 RepID=A0A2P6VWN7_9EURY  ali  14  135..............................................................................................................................GFPFTTDPKSTAESCEIVILATP-----PAETAEVLRDLEGDVLVMDVASLKS--------PIEDELERLAEDQPVTSVHPLWGPGTRDKNVLVCDCGHEEATERAVELFERSAAHVVRFPLDRHDEAMALTLGLPHALNLAYADVLAGSAFDYADLAELGGPTFLKQSDVAAEVAGENALYRQIQALNDES............................. 318
1050 4.000e-05UniRef50_A0A2E7K1Q0 Uncharacterized protein n=1 Tax=Rickettsiales bacterium TaxID=2026788 RepID=A0A2E7K1Q0_9RICK  ali  23  52................................................................................................................................EAASSAQEAVATADLILLCTPVGTY-GDVMQQIAAHIPENCMLSDVGSIK-------QEAITQVLRHKPEHCRFIPGHPIAGTEFKDHLMVITPLSTDEDIDAIKELWQHMQARIAFLPALAHDVI............................................................................................. 182
1051 4.000e-05UniRef50_A0A2V1E7W6 Uncharacterized protein n=1 Tax=Periconia macrospinosa TaxID=97972 RepID=A0A2V1E7W6_9PLEO  ali  17  63.........................................................................................................................RANEDDIKFTTNLNEALEGADFVQENGPKLQLKQTLFGEITSMVRHDTIL--ATSSSGLTCSSIQEGMSPSSHPERLIVG----HPFNPPHLPLVEVVGGSKTTPEVISKAMEFYSKAGRKPINIQKEVSGHVANRLQSALAREMMHLISEDVCTVKDL................................................................... 217
1052 4.000e-05UniRef50_A0A1W9LGG0 Uncharacterized protein (Fragment) n=1 Tax=Desulfobacteraceae bacterium A6 TaxID=1934249 RepID=A0A1W9LGG0_9DELT  ali  17  29......................................................................................................................HTVHISGRKTELTPADI--ARECDIVILSLPL-DVAIAVSEEIGPLLGDAQLLMDFCSLKEKILKSM---------TGSTSAEVIGTHPLFGPFTKGQNIILCPGRGEQWLKWLEDEYSSK............................................................................................................ 140
1053 4.000e-05UniRef50_C6C1D8 Prephenate dehydrogenase n=9 Tax=Desulfovibrio TaxID=872 RepID=C6C1D8_DESAD  ali  14  53...........................................................................................................................................DTDLVILCIPV-TVMDEVLPVVIPHLKKGAILSDVGSVKGRPVQQMLRAYDGP---------VVGTHPLFGPVIPADFDPTVALVAEREEDRVKDFFERLNFGAFESSVEEHDKAMAMIQALN---FSSTIAFLACSREIPNI-KKFVTPSFKRRLESARKMVTQ........................................... 208
1054 4.000e-05UniRef50_A0A0M0BQ48 Uncharacterized protein n=1 Tax=miscellaneous Crenarchaeota group archaeon SMTZ1-55 TaxID=1685133 RepID=A0A0M0BQ48_9ARCH  ali  17  31................................................................................PVQLQSRSEESVQRAMTNIRRNLGLLTRM------GLITSQQAEEALTKITTVLKDAVEDADLVIESVYEDALKQRIFKELDAACPEHTILVSTSTLPLSELQAVTHRPDRVLLAN------YSNPPYMVP---LVEMMRNERTSDDTVTTVYNLLTKIGKRPVIIQREVPGFIANRLQG....................................................................................... 199
1055 5.000e-05UniRef50_A0A2E4Y865 Prephenate dehydrogenase n=1 Tax=Halobacteriovoraceae bacterium TaxID=2026745 RepID=A0A2E4Y865_9PROT  ali  16  48......................................................................................................................................IEDLEGCRTVVLATPISTL-PKIIDWIKPHLNQEALVIDVCSVKEWPLTLMKEGL-------PNSVNILGTHPMFGPDSKNHKIVLCPESSEERLKKVTHYLQGLGLTLLTKTAKDHDEEISRSLILTHFIGRTLIHFGAEKLDI.................................................................... 190
1056 5.000e-05UniRef50_A0A1V5E0U1 L-carnitine dehydrogenase n=1 Tax=Smithella sp. PtaU1.Bin162 TaxID=1811697 RepID=A0A1V5E0U1_9DELT  ali  17  74...............................................................................................................................IEMGTDISWAVEDADFCIESVSENDLKKDIFGKMDQAAPQRAILASTSGQPMTEIAKATKRPE-------KCVIIHPLNPPHI--IPAVEVVKGTLTSDETVDLTVGLLKKIGRRPYVCLKEVPGFVMSRLLTVVLREALSLLKKGVATVEDIDTAIGLGLRFGLMGVFEIHNLTASGGLENFFK................................... 253
1057 5.000e-05UniRef50_A0A2A5NYI5 Uncharacterized protein n=1 Tax=Candidatus Geothermarchaeota archaeon ex4572_27 TaxID=2012530 RepID=A0A2A5NYI5_9ARCH  ali  15  39.............................................................................................................................LGAEWAS--VEEAGRFDFVVLTAP-PDRLEEAASRVAGHLRPGSIVMDVSSVKRGVVERVS-------RALPSHVAYVSLHPLFGPSTRRVEGRVVVVVPVRAVEPVVELMRGMGLRVVVSSADEHDMAMAAVQVAHHLSYLAYAVTLASS....................................................................... 182
1058 5.000e-05UniRef50_A0A1F5CVG8 3-hydroxybutyryl-CoA dehydrogenase (Fragment) n=3 Tax=cellular organisms TaxID=131567 RepID=A0A1F5CVG8_9ARCH  ali  17  26..................................................................................................................................TLDLKGAVSDADLIIEAVPENELKKAMFREVDTYAPANAVIANTSSVSITEIASATKRSE-------KVCGMHFFNPPQL--MKLIEVIRGAKTSDETIQTVLNVAHKMEKETVLVKKDCPGFIVNRILI....................................................................................... 148
1059 6.000e-05UniRef50_K2FJY2 3-hydroxyacyl-CoA dehydrogenase n=6 Tax=Bacillaceae TaxID=186817 RepID=K2FJY2_9BACI  ali  23  76.................................................................................................................................MTTDLKEAVQSADIVIEAVEKLDVKQEVFAELDKLAPKEAILTNSSSIVNSKIAEVTERP-------KKVVNMHFFFPPLV--MDCVEVVKSDQTSEETANAAVKFCEQLGRTAVLLEKEIYGFIANR.......................................................................................... 196
1060 7.000e-05UniRef50_UPI000A000976 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Labrenzia sp. DG1229 TaxID=681847 RepID=UPI000A000976  ali  14  81......................................................................................................................................LEEAASTDIVVLAMPVQYLS-EIVLAITPYLREGALVLDVCSVK--------KRPMELLARLPAHVDILGTHPLSGPGIAGLPIALVPMRGSK-LHQVKAFLKDKSLVVHVTTADDHDQEMAYVQGLTHL................................................................................... 206
1061 8.000e-05UniRef50_A0A2E7GB63 Fatty oxidation complex subunit alpha n=4 Tax=Bdellovibrionales TaxID=213481 RepID=A0A2E7GB63_9PROT  ali  13  415.....................................................................................................................................DYQGFSATDVVVEAVVEMDIKKKVLSELETHVKEDCVITNTSSLSVSEMQTVLKKPE-------RFLGMHFFNP--VHMMPLVEVIRGKETSDEAVATIYEFSKKLGKTPIVVPGFLVNRLCYLNEAAYLLAEGVPIDEIDRALLDFGMPMGPIELIDEVGVD-VGEKVGKILFEGFGDRMRPCEIYRSL........................ 601
1062 8.000e-05UniRef50_A0A1C7E7H3 3-hydroxybutyryl-CoA dehydrogenase n=12 Tax=Bacillales TaxID=1385 RepID=A0A1C7E7H3_9BACL  ali  15  69...............................................................................................................................VAFTTSLEEAVKDAEFIIEAVPENMALKHKIYHQLEELAANDIISNSSGLMPTALAEGMKHPERFVLT-------HFWNPAHL--VPLVEIVGGEKTDEKTLQQTKAFIEQMKKQAVMLKKELPGFIGNRLQFALFREAQALLDAGVASKEDIDA................................................................. 216
1063 8.000e-05UniRef50_A0A258WW92 2-hydroxy-3-oxopropionate reductase n=2 Tax=Sphingobacteriia TaxID=117747 RepID=A0A258WW92_9SPHI  ali  20  39..........................................................................................................................VQSAGAKLFDSIAELLADSDIIITMLPDSPEVKQVVSEILPAIKKGSLFIDMSTISPGVALEIYNSLKEKGVSAL-DAPVSGGQVGAEAGT--LSIMAGG--SEEAFNRALPVFQAMGKNIILIGDAGAGQVTKACQMIVGITIQAVAEAFSMAKKA.................................................................... 191
1064 9.000e-05UniRef50_A0A081SHZ6 Uncharacterized protein n=1 Tax=Candidatus Thermochlorobacteriaceae bacterium GBChlB TaxID=1519464 RepID=A0A081SHZ6_9BACT  ali  13  38.............................................................................................................................ADIELIDGQTSLADAADAVFFAVPIAAFETAV-KNAVPHFKDGALVMDVCSVK-------LHPERVLARLLPKGVYALPLHPMFGPGWRDLPLVLCPNADESDLYWRHYFSKGKGCRVVELTPEAHDRITARSLCLTQL................................................................................... 181
1065 9.000e-05UniRef50_D8EZN4 Putative 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Deltaproteobacteria TaxID=28221 RepID=D8EZN4_9DELT  ali  17  77..................................................................................................................................TTNLEEAVGKADFIIEAAPEDSLKQDLFEKIESFCSENAIIASNTS------SLTLQAIGERVKNKSRLVVTHWFNPPHI--VPTVEVVKNEDTGEETVDVAYELMEKIRKSPVKINWEIPGFIVNRIQIAMVREVLNL.............................................................................. 208
1066 1.000e-04UniRef50_A0A0C2DN53 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein n=1 Tax=Ancylostoma duodenale TaxID=51022 RepID=A0A0C2DN53_9BILA  ali  18  123...............................................................................................................................LELCSDIRSAVTEADYVIEAVEKKEVKDEVFVEAQEHCPQHALITNTSSIRLIDLLSS-------IRDHSRFAGLHFFNP--VPVMKLVEVVSSPDTSEETHTRLMDFCKSLGKRPV....................................................................................................... 232
1067 1.000e-04UniRef50_A0A1Q8DFN2 L-carnitine dehydrogenase n=32 Tax=Bacteria TaxID=2 RepID=A0A1Q8DFN2_STAAU  ali  22  63..............................................................................................................................NLSFTTDLKAAVKDADLIQENVPEVESIKDVLKEIDFYAKPSAIISSTSGIMPTELQKNLKYPERLVVA-------HPFHPVYI--LPLVEIVPGQSTSEETIIKAEEIYENIGMDVLHVRNEIEGHIADR.......................................................................................... 186
1068 1.000e-04UniRef50_A0A222SLG4 Prephenate dehydrogenase n=2 Tax=Prosthecochloris TaxID=1101 RepID=A0A222SLG4_9CHLB  ali  17  43................................................................................................................PAFGEEDITRIRELGLDRFETDMARLYDADLIILAAPVMTN-IALLDEVKRRAPEHALVSDVSSTKLTIALRAAEL----------GVNFVGMHPIAGRERQGYHASDEELLTEKAVRQLRELLESIRCRVVVMTPWEHDRIVAAISHLPQLLSVTLVTHFSSLARLAGSPWEIWRDIVATNRENIAS-----ELRSFSRKLD--ALAADVESGNMDRIGERFEQANRLYANLNE 284
1069 1.000e-04UniRef50_E3BB20 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein n=6 Tax=Dermacoccus TaxID=57495 RepID=E3BB20_9MICO  ali  18  55..................................................................................................................KGKLSSERDEIVGRVAFGDDLAAMKDADLVIEAVPELEIKTSIFTTLDDIVRDDCVLTNTSSLSITEIAKSTKEPSRV-------IGMHFFNPA--PVLPLVEVIHSLLTDVKLVEDVRELAVRLGKKPVVV-GDRAGFVAN--ALLIAYLARSIRAY........................................................................... 203
1070 1.000e-04UniRef50_A0A2W4M9L6 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=Firmicutes bacterium TaxID=1879010 RepID=A0A2W4M9L6_9FIRM  ali  19  81...........................................................................................................................EAAGRIATTTDLEALAPADAVIEAVPEDALKRRLFAELGRVCRRDALLTNTSSLSVTAIARDVSAPERI-------IGLHFFNP--VPAMRLVEVVRGALSGDEAVRRGMELATRLGKTPVITPAFIVNRVA............................................................................................ 208
1071 1.000e-04UniRef50_A0A2D7C4I9 3-hydroxybutyryl-CoA dehydrogenase (Fragment) n=2 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A2D7C4I9_9PROT  ali  15  42.................................................................................................QLNKATNTIEKNLEKQTRKKISEEDYKNSIEKITTQSIQKLNESQLIIEAATEDENTKKIFSELCPHLDKNTILCNTSSISITRLASQTDRPN-------QFMGLHFMNP--VPLMKLVELIKGITTDENTFHTVKIFAENLGKKLVISPAFIVNRI............................................................................................. 196
1072 1.000e-04UniRef50_A0A2U2S6E2 Uncharacterized protein n=1 Tax=Ardenticatenia bacterium TaxID=2099665 RepID=A0A2U2S6E2_9CHLR  ali  18  57....................................................................................................................................NLINACENADLIILALPL-HAIEDTLSVIAPYLKPGCVVTDTTVLKQKVL-------DAAERLLPETVNFIGGNPAASPSLEGHLYCLTPSAHPEAVHLVSSLVTLLGARPFYLDAAEHD---GLVAGAFHLPQLLALALWQSVTTDCGW-RDM-RKLIGGNYDTIGSLIGE........................................... 228
1073 1.000e-04UniRef50_A0A1W1C5L4 Enoyl-CoA hydratase / Delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase / 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxybutyryl-CoA ep  ali  18  381...................................................................................................................................TDTYNGFTNMDFIVEAVVEDKETKQVYKELEEIVKESCIIANTSSLSITML-------GENMKYPERFIGMHFFNP--VPRMPLVEIIAGEKTSDETIATVVKLARDAGKTAVLV-GDCAGFLVNRILL....................................................................................... 501
1074 2.000e-04UniRef50_A0A1M7RR90 Prephenate dehydrogenase n=1 Tax=Desulfovibrio litoralis DSM 11393 TaxID=1121455 RepID=A0A1M7RR90_9DELT  ali  9  44.......................................................................................................................................QEIKNAVAVVLCTPVEAIS-EIMSLITPYLDDNKLLMDISSIKVMPMQTMQQHYQGP---------IIGTHPLFGPGAKRVCISSKNIETTKWVEWSINFFRQMSFSPFITTPQIHDKAASAIQGLNFITSAA............................................................................... 181
1075 2.000e-04UniRef50_A0A2E4PSG9 Uncharacterized protein n=5 Tax=Chloroflexi bacterium TaxID=2026724 RepID=A0A2E4PSG9_9CHLR  ali  17  58.......................................................................................................................................KAVGDADLVIVATP-ARSVHDVFTAIAPHLKNGAVVTDTSPSKRAVTQWAEELL-------PKNTVFVGGNPLTGASVKEQKVVASPSADHNSIKTLTDLIESIDAKPVFMDPDEHDSFSAATTGLPAVVATALMN............................................................................ 198
1076 2.000e-04UniRef50_A0A2K2VYM5 Uncharacterized protein n=1 Tax=Desulfobacteraceae bacterium TaxID=2049433 RepID=A0A2K2VYM5_9DELT  ali  13  56..................................................................................................................................VADLEQGLSQADLVVLAVP-THSTLDVLADIPSHLQVGAVVCDVGRIKGPVLEKAAEVCHPVVFEEEKDID--EAYPALFQGRPCILTSGDR-RDEEAVKRIREVWEGAGCKVEEMDPEVHDRLFAVLEDLPIIFLSLVCKAAGQVSGYVDEIDEYSSNELKEITRLVAKV.............................................. 231
1077 2.000e-04UniRef50_A0A2H9I0D6 Uncharacterized protein n=1 Tax=Candidatus Bathyarchaeota archaeon B24-2 TaxID=2041147 RepID=A0A2H9I0D6_9ARCH  ali  17  45..............................................................................................................................GVNLCETNEEAALNSDITIVSVPI-RETPTVIERLKGTLKEGSVLIEISSLKCGVIEKLRE-------ISRMKVRAVSIHPLFGPSLKERKIVLVPVVDKNLEENCRRLFKDA--EFIALDAEEHDRFMGIVLSLTYLINLVFASTLRS........................................................................ 187
1078 2.000e-04UniRef50_A0A1W6JWW0 3-hydroxybutyryl-CoA dehydrogenase n=2 Tax=Acidianus TaxID=12914 RepID=A0A1W6JWW0_9CREN  ali  15  34......................................................................................................LNDVNDEILKNALNKIKWTELQKKGIHTTSNLEEALKDTDFMVEAVIEDINLKSKIFAKADEVSDGILATNTSSLPISEIAESTKKPERV-------IGMHFFNPPVL--MPLVEIIKGKLTSDNTVKETFQVTKNLGKEPVLAKKDIPGFIVTRIL........................................................................................ 195
1079 2.000e-04UniRef50_U3CK78 Putative 3-hydroxybutyryl-CoA dehydrogenase n=4 Tax=Proteobacteria TaxID=1224 RepID=U3CK78_9VIBR  ali  16  74...............................................................................................................................INITADAIEAYENADLIFESVPEMDIKHATFKEMEQYARPDCIFASGTSVKSIT------EIAEVVEKKERVIGMHFWNPAVL--IPLVEVIRTEDTNEDVFQASFDLLEDCGKAPAKCMKDVPGFLANRLQ........................................................................................ 198
1080 2.000e-04UniRef50_A0A060HDH4 Putative prephenate dehydrogenase n=2 Tax=Nitrososphaera TaxID=497726 RepID=A0A060HDH4_9ARCH  ali  21  31....................................................................................................................AFDVKPFEIKNVKNARNIADCVKNADLVMVCVPV-KHTPAVIKQCAKAMRKGALLAEISSIKAKAL--------PALKKTQKDIVALCIHPMFGPGAKQLKMLAVPVRNKEAINNVF-----AGMSVKVLPARTHDRAIAAVLGLTYVAFAGMLAREDLATNEVGGTTFAIQSMLAQSVELIAALIRDNAQRYMRQYMKEAGALASAKGSLLEAR................ 251
1081 2.000e-04UniRef50_A0A177CD74 Uncharacterized protein n=2 Tax=Massarineae TaxID=1255046 RepID=A0A177CD74_9PLEO  ali  16  76..............................................................................................................................DITFTTDLQEALRNADFVQENGPELDFKQSLFTDIAKHLPDHVII--ATSSSGLMCSKIQEGMPAASKPERCVVG----HPFNPPHLPLVEVVGGQLTSKSTIERTLQFYEDVGKKPIYVQKEVPGHIANRLQAALFREIFHIVKNDICTVKDI................................................................... 225
1082 3.000e-04UniRef50_A0A0R1QQ34 Prephenate dehydrogenase n=1 Tax=Lactobacillus manihotivorans DSM 13343 = JCM 12514 TaxID=1423769 RepID=A0A0R1QQ34_9LACO  ali  15  38....................................................................................................................SLKWAKVHQVIDVAAEQGLEAAGEADIIILATPVSEIVKELSQLSSLTLKPGVIVTDTGSTKATVMQAAQPLMA-------QGVAFVGGHPMAGSERSGHYFLVNGNASEDQILALRNVLSAAGAYFEILSAKQHDQMVAQISHVPHVVASALAISAAQGLKDQPQALQFSAGGFRDTTRTMWTAIMQSNTKAILKALDTDATLQQARDLIAANDRKGMHAWFEHAQQVRQ 280
1083 3.000e-04UniRef50_A0A2V9WAL6 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=Acidobacteria bacterium TaxID=1978231 RepID=A0A2V9WAL6_9BACT  ali  16  5..............................................................................IAYAAALGGYRTILEDLLPALRKAESEIRANLDKAVEGKVTAPDADSARLEYAGSVEEAAREADLVIEAVPEEMESKIEIFTLLDKIPTTMLASNTSSLSLTEIASVTYR-------AKKCVGMHFFNP--VHKMKLLEIVRALETDDETLATAVEVGKRMRKEVVVIPGFITSRINAMAFYMLQEGIASAADIDKALKLGLNHPMGPFELVDLVGLDTRLSILE............................................ 233
1084 3.000e-04UniRef50_E2SHR7 Prephenate dehydrogenase n=1 Tax=Erysipelotrichaceae bacterium 3_1_53 TaxID=658659 RepID=E2SHR7_9FIRM  ali  20  64.....................................................................................................................................DIDYIKEADIIISGL-YPNMTVDWITTYQKYFKPGALITDVSSVKTGVVK-------PIQNIIRKDVEFISSHPMAGKEVSGVKFADDSINSREAVDTMRQFADILGRNISELTVEQHDEMVGFVSHLTHAIAVSLMNTND......................................................................... 210
1085 3.000e-04UniRef50_A0A0G3UY47 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=Actinobacteria bacterium IMCC26256 TaxID=1650658 RepID=A0A0G3UY47_9ACTN  ali  19  70.................................................................................................................................VTTDLANAVRDADVVVEAVPEDSIKQAVFERIGVAVNDHAVLANTSGLPIGVLGAASGRPA-------QTVGTHFFNP--VPAMRLVEVVRGADTSPEILQKALAFCQALGKETVEV-ADLPGFVTTLGTLLMAEAVRVLQEGVASAEHITGMRLGYNHPMGPLALA------DRIGLDTLLAILD................................ 243
1086 3.000e-04UniRef50_A0A292YKT8 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=Effusibacillus lacus TaxID=1348429 RepID=A0A292YKT8_9BACL  ali  20  16.........................................................................................................................KMAFARMHLTTDLAEAVGTSDFIVEAVEKLEEKRQLFAKLDELAPKHAILTNSSTIVNSKIATATSRPD-------KVCNMHFFNPPL--KMDLVEVVTGPETSEETARTAVKLVKKLGKTPILLRKEISGFIANRLLGAMNREALSLLE............................................................................ 158
1087 3.000e-04UniRef50_Q2S245 Prephenate dehydrogenase n=26 Tax=Bacteria TaxID=2 RepID=Q2S245_SALRD  ali  18  51........................................................................................................................ERAEERGAEKAADPLSAVADTDLVVLATPLA-TTVRLLDTIADALPEGCFVTDVASVKEPVLDQAADVL-------PDHATFLGGHPMAGAEHSGIDHDTDEAALDEGLAPLVELIEATGSRPLVLDAPRHDRLVAATSHVPQLLSVALVNLVATTEDD--ADRDLALQLAGGGFRDMTRI.............................................. 240
1088 3.000e-04UniRef50_A0A255H045 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=Propionibacteriaceae bacterium NML 130396 TaxID=2016507 RepID=A0A255H045_9ACTN  ali  18  81...............................................................................................................................IDFTTDTAVGVKDADLVVEAVSKLELKQQIFRTVDEAAPAHAILTNTSSLSITSIATVVTDPSRVL-------GVHFFNPA--PVQTLVELIRAIHTSDAAIDRMTRLMTSLGKSPIVC-GDRAGFIVNALLV....................................................................................... 205
1089 4.000e-04UniRef50_A0A1X0XT60 3-hydroxybutyryl-CoA dehydrogenase n=3 Tax=Geobacteraceae TaxID=213422 RepID=A0A1X0XT60_9DELT  ali  21  72..................................................................................................................................TASLKEAVGDAGFITEAVPEQALKWQIFSRIEAHAPATAIIANTSTLPLSELSRQLAQPERMLIT-------HFFNPAHL--VPLVEIVRAENTPEETLTTLLNLLRRAGKTPVVLKKEVPGFIANRLQAAIHLVESGVASEQDIDLAVTAGP................................................................ 222
1090 4.000e-04UniRef50_UPI000984F551 pyrroline-5-carboxylate reductase n=1 Tax=Sinomonas mesophila TaxID=1531955 RepID=UPI000984F551  ali  18  53......................................................................................................................HVERIAQYGVTGGTDNREAVTTAELVVVGV-EPEQVAGVLDEIADALPSTAVVV------SLAARVTTQELEAHLRQGSAVVRVMPNTPAQV--GEGLAVLTPGLNSEEQLQKVRDFF-SLSGEVIVVPEEQQRAVGALGTGPAHFFY--VVDAMIEAGVAMGLRRDMARSVVVQTIVGAGALLRESG......................................... 231
1091 4.000e-04UniRef50_A0A1M5RXB2 Ketoreductase RED1 n=2 Tax=Streptomyces TaxID=1883 RepID=A0A1M5RXB2_9ACTN  ali  21  69...............................................................................................................................VRLVVDLTEAVYGADVIQESGPENEEKARTAAQALSAAPSHAILSSTSQIPAGVFTKSLEHADRILV----------AHPLNPPGMPLVEVVPGERTSQAAVDRAVEFYRSVGRTPVVEHKEVRGFVATELQNVLAR................................................................................... 198
1092 4.000e-04UniRef50_UPI00068ACEF4 hypothetical protein n=1 Tax=Salinicoccus sp. YB14-2 TaxID=1572701 RepID=UPI00068ACEF4  ali  12  78.......................................................................................................................................................NIKKEVIENIEKYVPKETIICNTSGLPLSEIGKNMNIPE-------RFIGMHFYTPSTI--IPLVEVIKSQFTSERTAKTTYDFLVKVGKKPVLLKREIPGFIGNRIQHVIMREALFLLEKEVASIEDIDE................................................................. 200
1093 4.000e-04UniRef50_A0A1H0VNJ5 7-keto-8-aminopelargonate synthetase n=2 Tax=Lentzea jiangxiensis TaxID=641025 RepID=A0A1H0VNJ5_9PSEU  ali  17  60............................................................................................................................................ADLVLLAVPE-RVALAALPVLAEHVRPGALVADTLSVKSAV---------APVLTGLREVEAVSLNPMFAPGFAGESVAAVVVHDGPKVTELLALVGEWGAHVVRLSAADHDRLAAATQVLTHAAVLGFGLALAGLTDGVGEVAPLATP.......................................................... 200
1094 4.000e-04UniRef50_A0A1K1LH39 Prephenate and/or arogenate dehydrogenase n=11 Tax=Desulfovibrio TaxID=872 RepID=A0A1K1LH39_9DELT  ali  15  64........................................................................................................................................ACRDAALVLLCVP-AAVFAEVAATVCAHLPDTAILADITSVKVRPLQQMEAVWPGP---------VVGTHPLFGPATPDPVTVTPGRTAREQDTALVEFFRALGCSTFRATADEHDRAMARVQFITNLAYFALL............................................................................. 195
1095 5.000e-04UniRef50_A0A2W5PYF5 Carnitine 3-dehydrogenase n=1 Tax=Rhodovulum sulfidophilum TaxID=35806 RepID=A0A2W5PYF5_RHOSU  ali  19  178............................................................................................................DAPRPPRGRLSFARSIEA----------AVAGADFIQESVPELELKSRILAEIAAAAPEALIGSSTSGLPPSDLQAGMANPTRLVVA-------HPFNPVYL--LPLVEIVAGKATSPGAVARAVELYTAIGMKPVVIRREIEAFVGDR.......................................................................................... 309
1096 5.000e-04UniRef50_A0A2E0KPW0 3-hydroxybutyryl-CoA dehydrogenase (Fragment) n=2 Tax=Euryarchaeota archaeon TaxID=2026739 RepID=A0A2E0KPW0_9EURY  ali  15  30..................................................................................NLYDAFPEGLERGMNTIDSFWDKGIARGKTTPEQKEEW----SANLHAISDLRLAVKDVDLVIEAVPIMEIKARIFHVLSIETKEDCILTNTSSLSISDIAQASDRPD-------KVIGMHFFNP--VPIMKLLEIVRHDSCSEATIAAAQSIGSAMGKETILVNDVPGFATSRLGVVLGNEAIRMLADGVASAKDI.................................................................... 215
1097 5.000e-04UniRef50_A0A2J6WW27 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=Aciduliprofundum sp. TaxID=2060325 RepID=A0A2J6WW27_9EURY  ali  14  79..........................................................................................................................................EHIDIVIEAVVEKSSVKKELFKILDERFDSILATNTSSIPI-------DEIARDLKGRKRIIGMHFFNPPTL--INLVEIIPGEYTSTETIEKAMEFSRSLGMETILVKRDIPGFVVNRINL---RIFDTVLTMAENGVDI.................................................................... 207
1098 5.000e-04UniRef50_X1B0L0 Uncharacterized protein (Fragment) n=1 Tax=marine sediment metagenome TaxID=412755 RepID=X1B0L0_9ZZZZ  ali  23  54.................................................................................................................................VAVDYKEAVTDADLIIIATPISKI-IEVVEHIKDYLKKGVIITDVGSAKEKIVKRVSEIL-------PEGVFFIGGHPMAGSENEGILYILTPTDTTEPLVTLHSLFTKIGSKVISINPKEHDENVALISHL...................................................................................... 190
1099 5.000e-04UniRef50_A0A1F5IST2 Uncharacterized protein n=2 Tax=Candidatus Daviesbacteria TaxID=1752718 RepID=A0A1F5IST2_9BACT  ali  12  67............................................................................................................................................ADIVIPCVPISEFK-KVILQIAPLLTNVAVVMDVCSIKVLPARIMKKHL-------PKNIQIIASHPMFGPGLKNLKLVLHNVRADQPVSKIKSFFKQLELKVIELSPQKHD............................................................................................... 178
1100 6.000e-04UniRef50_L0K333 3-hydroxyacyl-CoA dehydrogenase n=111 Tax=Halobacteria TaxID=183963 RepID=L0K333_9EURY  ali  17  73...............................................................................................................................IETTTDLADAVADAELVIEAAPENELKRELFADLERFADEDALLTNTSSLPITDVAAAVDSPERVL-------GLHFFNPPV--KMDLVEVIYGAETSDEVAEAGHDWVESIGKTPIYVRKDVRGFVVNTIVG....................................................................................... 198
1101 6.000e-04UniRef50_A0A1Y5KD41 Uncharacterized protein n=2 Tax=Paenibacillus TaxID=44249 RepID=A0A1Y5KD41_9BACL  ali  16  50.............................................................................................................................LNIQLTNNFEKAVANADLIIECVPEQTVKREVYRQLASAIREAIVASNTSTFP-------LQTLAQELPFANQMVIVHFFNPAHL--IPLVEIVGLPDTPPSILEELAALLRKCGKTPVVLNKDIPGFIANRLQA....................................................................................... 177
1102 6.000e-04UniRef50_A0A1H9VHI7 Pyrroline-5-carboxylate reductase n=2 Tax=Corynebacterium TaxID=1716 RepID=A0A1H9VHI7_9CORY  ali  18  48..............................................................................................................................GVHTTDDNNEAAANADVVFLCVKPAGI-VDVIDEISDTVADNDVATTLVSMAAGVTIETMEEAISAAGTS--IVRVMPNTPMLV-GKGVCAVAPGKFVAEDQLDYVVKLLEATG-RVVVVPESQMDAVTALSGSGPAYIFLVAEAMIDAGVS-LGVSRDSAQELVSATIAGAGAMLEQEGAD....................................... 223
1103 6.000e-04UniRef50_A0A1V5CSH4 Putative 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Syntrophorhabdus sp. PtaU1.Bin050 TaxID=1811703 RepID=A0A1V5CSH4_9DELT  ali  17  57..................................................................................................................KGKMTQEKADEASMRFTTDLKEAAKDADLVIESIPEAKTTFKELDSICP--PHTILATNTSSLSVTEIGSLTKRQD-------KVVGWHFSNPVAM--LKHCELIRGFNTSDETMETMKELSRIFERDIVIMK.................................................................................................... 184
1104 7.000e-04UniRef50_A0A1I7JQF8 3-hydroxybutyryl-CoA dehydrogenase n=1 Tax=Alicyclobacillus macrosporangiidus TaxID=392015 RepID=A0A1I7JQF8_9BACL  ali  13  67.............................................................................................................................ARVETTTDLREAVAGSCWVTEAIPELPLKHDLYAQLEEKVAKSCVIANTSTLPLAELTARAKHPERFVIT-------HFFNPAQL--VPLVEIVRGPQTREDVVQEAVAMLRRLGKAPVVLKKDVPGFIANRLQAALVR................................................................................... 198
1105 7.000e-04UniRef50_A0A0G1SG43 Prephenate dehydrogenase n=1 Tax=Parcubacteria group bacterium GW2011_GWA2_47_16 TaxID=1618842 RepID=A0A0G1SG43_9BACT  ali  15  42..................................................................................................................KTSTHVHNHVEIVFPTSDENVELVKWADVVVFSILPIQAGLTEMSHQAKHSRPDQLWVDMTSVKAEPITKMLESRA----------EVVGLHPSGVPQGKLMVVPARLYVWKEWVEW---FLKETGAKIKTMTAEEHDRMALMNQVVPH.................................................................................... 183
1106 8.000e-04UniRef50_A0A0S8HSR6 Uncharacterized protein (Fragment) n=1 Tax=Deltaproteobacteria bacterium SM23_61 TaxID=1703399 RepID=A0A0S8HSR6_9DELT  ali  19  45...............................................................................................................................IAVTTHLEEAVSKADFVLEAVPIMDLKKETFVKLDRFAPFHAILANTSGLSITQIGSVTQRPE-------KTIIVHWINPPTI--IPVVEIVRGEKTSDETAELCYRLLLKLGKRPVRVLREVPGFLFNRLQM....................................................................................... 170
1107 8.000e-04UniRef50_A0A2H3P0D4 Prephenate dehydrogenase n=1 Tax=Longimonas halophila TaxID=1469170 RepID=A0A2H3P0D4_9BACT  ali  17  62........................................................................................................................................AVDGADLVILAFPPAKIASAM-EPLAPHLTEGAVVTDVASVKQAVVDQAQEVL-------PEHVTFVGGHPMAGAETAGVAYVLTPTDDTEALSNMRAVVEVVGATPVVLAPEAHDRIVARVSHLPQLLAVTLVQHAAESNDD.................................................................... 209
1108 9.000e-04UniRef50_A0A2K8QY16 3-hydroxybutyryl-CoA dehydrogenase n=176 Tax=Actinobacteria TaxID=201174 RepID=A0A2K8QY16_9ACTN  ali  19  29....................................................................................................RRVIAVERDEPALRRGRERVTAAESA-VEFTTDPAAAAR-ADLVIEAVPERLETKRLARAHAECPPETVFATTTTGLPVT------EIAFGSGRTDR-TVGLHLFPLGPDREAPAVEVVGTPLTADAVLADVRELIRDLGRIPVPV-ADRPGFIGNNAVAMYERRYASRDSIDTAMTLGCGLPMGPLAQLDAMGLDTLEALYERTG......................................... 238
1109 9.000e-04UniRef50_A0A1E7HC05 Uncharacterized protein n=3 Tax=unclassified Desulfobulbaceae TaxID=231686 RepID=A0A1E7HC05_9DELT  ali  15  37.........................................................................................................................RPEEVSPGIEIASESGIYDCDALFFCVAISSF-EEVLKKSSHHCNKGTVFFDTCSVKVFPAKWMK-------KYLPEGSTIIATHPMFGPDSYLQTERQLPLADQETIEEWADYFKSKSLQVEIMTAEKHDQMTAYSQGITHYVVLADLDLHPTLIDTLGYKKEVIEQTCNDSWQLFLDLQNYNPYEKMRESLH-EAIERVNLSLN.................... 244
1110 9.000e-04UniRef50_D5RGA9 Prephenate dehydrogenase n=10 Tax=Rhodospirillales TaxID=204441 RepID=D5RGA9_9PROT  ali  16  62......................................................................................................................................AEAARQP-VVILAVPVARLA-EVARAIAPHLRPGALVVEVCSIKTRPLALLREAL-------PEHVELLGTHPLFGPGIEGLRLVACP-GGGARARLALRMLRRLGLQLVTMTPEEHDRQMAWVQGLTHLV.................................................................................. 187
1111 1.000e-03UniRef50_A0A163L8V4 Uncharacterized protein n=1 Tax=Didymella rabiei TaxID=5454 RepID=A0A163L8V4_DIDRA  ali  20  435........................................................................................LETKEEFAAAARERIAKSINR--GVAKGKITQEEADAAIARVVTLDMEEFADRDLVIEAAPEIELKYEIFGKLDKIVKPGILATNTSSIPVIKIAKATSRPGQV-------VGVHFFNP--VPVMPLVEIVVSLTTSEETVLAVTDYAKNTLRKKTVRAGDRSGFIVNLCQAVRMLGYATAEDIDEAMKGGCGYPMGPLTLLDTVGLDIALAAAESLYAEFAEPHYAPPALLR.......................... 667
1112 1.000e-03UniRef50_A0A2E7S2N5 3-hydroxybutyryl-CoA dehydrogenase n=4 Tax=Planctomycetaceae bacterium TaxID=2026779 RepID=A0A2E7S2N5_9PLAN  ali  16  76..................................................................................................................................STDLGQSVADADLVIEAVPEDDLKCRIFSELAP--PRTALVSNTSGLSITRLGQATGRPEQVA-------GFHWWNPAEL--VPLVEVTSGESTAPELIEQLIDLATQLGKQPIHVRRDVPGFVGNRLQFALHLVEQGVVSPEDLDRAMTGGP................................................................ 226
1113 1.000e-03UniRef50_A0A2E1RPL8 Uncharacterized protein n=7 Tax=Bacteria TaxID=2 RepID=A0A2E1RPL8_9BACT  ali  18  38....................................................................................................................AIDELRKLDIANIVSGELKEIIPNSDLIVFATPVGAV-EKILCQLLPLAKKGAVITDLCSVKSSVVNLIDKV---ILDSDRSDLEFVGAHPMAGAEVSGVCAITPGDTSSKASEILVQFWDSLGCKCVMIDPKVHDEMVAKVSHLPHLISSALA............................................................................. 200
1114 1.000e-03UniRef50_A0A0F9MAB9 Uncharacterized protein n=8 Tax=root TaxID=1 RepID=A0A0F9MAB9_9ZZZZ  ali  22  69.......................................................................................................................................EAVKDVDLVIEAVPKLELKRKIFPEIEKAAPPHAIITNSSSIPISKIEDTVERKDK----------VMNIHFYDLFTMPMADIMRGTHTSEETFERGRKWLESIEITPLEVKKECYGFVMNRI......................................................................................... 183
1115 1.000e-03UniRef50_A0A162SMY3 Putative 3-hydroxybutyryl-CoA dehydrogenase n=10 Tax=Firmicutes TaxID=1239 RepID=A0A162SMY3_9CLOT  ali  14  80........................................................................................................................................AAKDVDLVIECIDENELKQKIFKQLDELCLENVILSTTSGLSPTAIAKNTKHPERVVVA-------HFWNPPQL--MPLVEVVPGEKTSQETVNKTIEWVESIGKKAIIMKKECIGFIGNRLQ........................................................................................ 195
1116 1.000e-03UniRef50_A0A075P287 3-hydroxyacyl-CoA dehydrogenase n=2 Tax=Alteromonas TaxID=226 RepID=A0A075P287_9ALTE  ali  17  64...............................................................................................................................ISVVSDIEAAVANADVIIEAVPKLSLKQEVFQQIQPLIKSTAIVANTSVIPIKDIFDGLDFQNQV-------VGTHWWNPPYL--VPLVEVVESEKSSTDVIKKMMALLTFVGKKPVHVKKDVPGFVGNRMQ........................................................................................ 188
1117 1.000e-03UniRef50_R4Z2Y3 Putative Prephenate dehydratase n=1 Tax=Candidatus Microthrix parvicella RN1 TaxID=1229780 RepID=R4Z2Y3_9ACTN  ali  24  107.................................................................................................................................................LAVP-ADAVDTIASAVLPLPAPGSIVFDVTSSKNQPL--------AALRARRDDLAVFGTHPLFGPGPAGQTVVVCPPADPEAHRWLSDLFATAGTAVHEVSAEEHDQAMSWVQALTHIVFAGLVS............................................................................ 230
1118 1.000e-03UniRef50_Q0AQZ7 Prephenate dehydrogenase n=5 Tax=Maricaulis TaxID=74317 RepID=Q0AQZ7_MARMM  ali  13  29......................................................................................................................HDPAVAELDSVACVSLAEAASRP-VVILAVPV-QLIAEACQQIAPHLPEGALVLDVASVKLKPMAAMRAHLPAGTR-------ILGTHPLFGPGLGGQSIVLCPEPGVDPACIADFLRDDLRLDVHISDADTHDRTMASVQALTHLV.................................................................................. 171
1119 1.000e-03UniRef50_UPI0009336A45 enoyl-CoA hydratase n=3 Tax=Arcobacter TaxID=28196 RepID=UPI0009336A45  ali  16  377...................................................................................................................................TDNYDGMNNTELAIEAIIEDEAKKDTFAELEKVLGKDSIIANTSSISI-------EKLSSELKNKKNFVGVHFFNP--VNMMPLVEIIPSSHTSKKTINRVTELLVSCGKTPIVV-GDCAGFIVNRILLPYLNEAAFILEEGLSVSKIDKVLKDFGMPMGPFIL---ADTVGIDIGYKVTKILNE----AYGDRMPMAPILDRVYNDLKLLGAKNK 577
1120 1.000e-03UniRef50_A0A1Z9UYT9 Uncharacterized protein (Fragment) n=1 Tax=Rickettsiales bacterium TMED289 TaxID=1986873 RepID=A0A1Z9UYT9_9RICK  ali  16  44.........................................................................................................................................IEKSDWIILCVPI-DQTLDVINNVKSRIKNDQVFSDFTSVK------------SIIKDVEFDFEFISCHPLFGPTINGQNIITIPVSEGPYYKDIKEIFKKIGLNVTEISIEEHDKYMSLIQGMTHFS.................................................................................. 161
1121 1.000e-03UniRef50_A0A1F5DCR0 Uncharacterized protein n=1 Tax=Candidatus Bathyarchaeota archaeon RBG_13_38_9 TaxID=1797377 RepID=A0A1F5DCR0_9ARCH  ali  15  27.............................................................................................KILKDKVETINIVSREVGRAQEAA------QELNVSWLP--LEEAHQSNIVIISVPIPE-TVKICKSIGQKMHDQSLLVELASLKTGI-------TEIIKSSIPNCVEYLSLHPLFGPQVKGKRFVAVEPASGSLTTEFLEMLQECGSVIKKATVKEHDLAMASIQVLHHFALITFSSALSRFAEENGLSEYLTES-LEKTLQNIENIYENWDTIYAIQSLNPNAILAEVANQSIDAKNEPLRQAISLLRK... 271
1122 1.000e-03UniRef50_A0A2C7AAZ2 Prephenate dehydrogenase n=1 Tax=Roseomonas rhizosphaerae TaxID=1335062 RepID=A0A2C7AAZ2_9PROT  ali  17  64...........................................................................................................................................................EVARAIAPHLRPGALVVEVCSLKLRPLAALRAALPAH-------VEILGTHPLFGPGIEGLRVVVCP-GGGAPLRLAARMLRRLGLQVVRMTPEEHDRQMAWVQGLTHLVVAGLLPHTTSSFDQLMRATAMVSQDSEALFRTITEFVEEVKMERMEEILGPSAM............................ 237
1123 1.000e-03UniRef50_UPI0006842931 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Desulfovibrio cuneatus TaxID=159728 RepID=UPI000684293  ali  18  85..................................................................................................................................TDALAAAVLGAEVVMLCVP-TNALPDVLALLVPLLQPHQVLADVCSVKTLPLAAMCAAHNGP---------VVGTHPLFGPVATKKDLAVAVTPGEGTPETAVELVETLGCRVFRTTAAEHDRGVGFAQALN---FASNAIYFATVADQLPGIMPFITP.......................................................... 234
1124 1.000e-03UniRef50_A0A1Z8SRH1 3-hydroxybutyryl-CoA dehydrogenase (Fragment) n=1 Tax=Planctomycetia bacterium TMED53 TaxID=1986839 RepID=A0A1Z8SRH1_9BACT  ali  20  69..............................................................................................................................GLRTESDLEKACAGSEIVIEAVPKVELKRSIFGQVESVVSSDAILTNTSSIPIRDLA-------GSLKNPARFVGMHFFNP--VPVMSLIEIIRGEQTSDATIDRSVEFAAKLAKEPIVVK.................................................................................................... 182
1125 1.000e-03UniRef50_Q96Y98 Putative chorismate mutase/prephenate dehydrogenase n=29 Tax=Sulfolobales TaxID=2281 RepID=Q96Y98_SULTO  ali  15  141....................................................................................................................................DLDSALNWGEYIILA-----LSPSSFDYILRISPKSKVVMDIFS-SKNEIFKELEKLSEIY-----SFNYISTHPLFGPITVGERIVIIPSKTSKNVNEIVNFWRECGLNTTVSTVEEHEKAMAIVQVLAHFYILGLHRSIDELRKELG--IENLSNFYTTNFKELNKIIEKV.......................................... 304
1126 1.000e-03UniRef50_A0A212LZ11 3-hydroxybutyryl-CoA dehydrogenase n=3 Tax=Firmicutes TaxID=1239 RepID=A0A212LZ11_9FIRM  ali  16  72.............................................................................................................................AKIEGVTTLEEAAADADFVIESIPIKQEVFTKLDKICR--PHTIFATNTSGLSPTKIAEAIGRKD-------KFVVAHFWNPPHI--VPLVEVVPGKHTSQETVDVTWQLMEKIGKKPVALNREALGFIGNRLQLALLREALYIVESGIASKEAVDTTMKY............................................................. 225
1127 0.002UniRef50_A0A1U9YVV8 Putative 3-hydroxybutyryl-CoA dehydrogenase n=34 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A1U9YVV8_9RHIZ  ali  18  64...............................................................................................................................VKLTSDLAEAVAGADLVIENVPKADIKAGVYRQIDALIPDVIVASDTSGIPITSLQEHISNPARM-------VGMHWSNPPHI--IPMIEVIAGAQTAPETSEAIKTLIRSLGLLPVTVKKDVPGFVENRVL........................................................................................ 188
1128 0.002UniRef50_Q5LTH8 L-carnitine dehydrogenase n=14 Tax=Proteobacteria TaxID=1224 RepID=LCDH_RUEPO  ali  19  30..............................................................................FDPDP---EAERKIGEVLANARRSLPGLS-DMPLPPEGKLSFH--ADLG--------EAVTGAAWIQESVPELDLKLKVYRSIQEACDPGAILSSTSGFKPSELQEGALRPGQIVVT-------HPFNPVYL--LPLIELVTTPENSPEMIERAKEIMRGLGQFPLHVRKEIDAHIADR.......................................................................................... 187
1129 0.002UniRef50_A0A2E4Y013 Uncharacterized protein n=2 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A2E4Y013_9PROT  ali  18  48.......................................................................................................................................EEAAGCDAVILAVPISAYQETLSR-VRPHLRPNSVVIDIATVKTMDLLQATEPP----------VQFLSMHPMFGPESSGFRIVITGHNTPGNIYSAFDLLTDAGFSIIETTADAHDKDLAETLFLTHYI.................................................................................. 177
1130 0.002UniRef50_A1HS59 Prephenate dehydrogenase n=1 Tax=Thermosinus carboxydivorans Nor1 TaxID=401526 RepID=A1HS59_9FIRM  ali  21  59.......................................................................................................................................EAVNGADVVIFCLPVSHIPAAIAEAAP-YFKPGAVITDVASAKGCLLA-------TVPGLMPREVTYIGGHPMAGSEKSGELFVGRPYASDEAMARLRQIITAIGAIPVVMDGELHDMVVAQISHIPHIMAAALVNLAGSGK...................................................................... 205
1131 0.002UniRef50_UPI000984DF77 prephenate dehydrogenase/arogenate dehydrogenase family protein n=1 Tax=Marinicella sediminis TaxID=1792834 RepID=UPI000984DF7  ali  19  153.............................................................................................................................................DYIIVATPIQK-SAEILIELCDLQPSGIVL-DISSIKSPLRLPLRQLADSGCR-------VVSIHPMFGPDMSGKHVVFIDMGNEEAVNQVKQLFQPTMAERIDMKFEDHDRLIAYVLGLSHIAFMTVLSESGEAADAL................................................................... 288
1132 0.002UniRef50_A0A0P7CAA9 Prephenate dehydrogenase n=1 Tax=Jiulongibacter sediminis TaxID=1605367 RepID=A0A0P7CAA9_9BACT  ali  15  30............................................................................................................DLPENAESLSHIFEDNDL-VNICKSSKEVIENS-VYLIFSVETNKIESVVRELAPYVRKGHIVAGQTSVKNPEV-------RAFKKYLNDDVDIATLHSLHGPHVKGQTLVAIPERSSERFKEVLGVLSCMESKIEVLDADVHDKMMADIQVVTHIGFESI.............................................................................. 185
1133 0.002UniRef50_UPI000C07345A 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=Anaerococcus sp. Marseille-P3625 TaxID=1977277 RepID=UPI000C07345A  ali  21  100..............................................................................................................................ELKYTTDLKEAFADADLVIEAIAERDEKKAFYEKIAPFLKEEAIITNSSTLLPSTFKEYTGREEKFL----------SLHFANNIHRQNLEVMKHDTTSEEALNLVVDFAKSIGMYPAVIKKEQPGYILN........................................................................................... 222
1134 0.002UniRef50_A0A2K2WED2 3-hydroxybutyryl-CoA dehydrogenase (Fragment) n=2 Tax=Chryseobacterium TaxID=59732 RepID=A0A2K2WED2_9FLAO  ali  14  35................................................................................................PQIDKALSGLEKTLQKVEKGKISQEKATDIRNNIAKGETQDLKDSDLVIEAIIENDIKTKVFTELETYVSENCI------IGSNTSSISITSLGAELKKPERFIGIHFFNPA--PLMPLVEVIPSLLTEKTLAEKIYNLMKDWGKTP-VIAKDIPGFIVNRIA........................................................................................ 191
1135 0.002UniRef50_A0A2E8I1W4 Uncharacterized protein n=1 Tax=Zetaproteobacteria bacterium TaxID=2026807 RepID=A0A2E8I1W4_9PROT  ali  18  141..................................................................................................................................VAESIEXCKNADLILVATPLA-ATSXVLEDIIKIRPQGTVV-EICSLKXPXIDTIAKARSSQIK-------IASIHPMFGPDIEGKNIIVCTGVNHEATQSILSILXQTTANIVSIPIEEHDNXMGYVLGITHL................................................................................... 268
1136 0.002UniRef50_A0A1V5LMS8 Prephenate dehydrogenase n=1 Tax=bacterium ADurb.Bin429 TaxID=1866930 RepID=A0A1V5LMS8_9BACT  ali  20  61.....................................................................................................................................ELDAVRGADLVVLCTPVQTIVAQLL-EMAPHLAPGAVVTDVGSTKRVIMNAATALPTGIFFVGG--------HPMAGSDRKGLSHARLGLGAEAAAERLVELIQTLGAIPLPIEAGFHDELVALSSHLPH.................................................................................... 193
1137 0.002UniRef50_A0A0M3KEQ7 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (inferred by orthology to a human protein) n=1 Tax=Anisakis simplex TaxID=626  ali  22  4.........................................................................TVVDRTD--AILEKARAAIDKSVRRIAKK--KFADDT------KAQDAMVEDVHITMTTDIPQSVKEADLVIEAIVENTMKRNVFEQIEGASRTGTLLTNTSSIS-------LAEIAANLKRKSNFAGLHFFNP--VPVMKLLEVARYRETSDETFNTLMEFGKTIGKTTV....................................................................................................... 159
1138 0.002UniRef50_A0A2J0LAM8 Enoyl-CoA hydratase (Fragment) n=1 Tax=Candidatus Omnitrophica bacterium CG12_big_fil_rev_8_21_14_0_65_50_5 TaxID=1974754 RepID=A  ali  16  2......................................................................................................................................................MDVKKKVFKELSDNTKQGCILTNTSALSVTEMAAQTKDPSRV-------IGIHFFNP--VHRMPLVEIVKTPQTSDETIARTLAFVKRLKKIPIVVN-DAYGFVVNRILLAYVNEAGHLLEETGDITGIDKVAADFGMPMGPLELS------DEVGLDVGYKVL................................. 150
1139 0.003UniRef50_D1AE03 3-hydroxybutyryl-CoA dehydrogenase n=7 Tax=Actinobacteria TaxID=201174 RepID=D1AE03_THECD  ali  16  417.........................................................................................................................................................................................................VVGLHPEAGP---LVEVASTVLTAPRAAERAVALTAALGLTPVRCR-DRAGFIVDALRFPYLNDAVRMLEADAAMRLGCGYPTGPIADLDRLGLDRAVAVLRALYAERRENAFAPAPLLEEY........................ 544
1140 0.003UniRef50_UPI00069C6BC6 3-hydroxyacyl-CoA dehydrogenase family protein n=1 Tax=Aneurinibacillus tyrosinisolvens TaxID=1443435 RepID=UPI00069C6BC6  ali  17  6.............................................................................................................................ARITYTTNLHEALEGADFVLESIPEKLETYEIIESVVSD--KTIISSNTSTFPLKELTQRAKNPERFIIT-------HFFNPPQL--VPLVEIVKVDNTDEKVIKLTYDLMKEMGRSPVLLQKEVPGFIVNRIQV....................................................................................... 133
1141 0.003UniRef50_A0A0F2Q620 2-hydroxy-3-oxopropionate reductase n=1 Tax=Hoeflea sp. BRH_c9 TaxID=1629712 RepID=A0A0F2Q620_9RHIZ  ali  22  46.........................................................................................................................RIADEGAESAANATELVGKADIVILSLPNGEAVESIISEVSANIKPGQVIIDTSTTPVALTKEMAARVRA----------------------AGADYLDAPIARTRQAAEDGTLSIMVGGD--ISAFERVRPILEMGSDVTHCGPVG-------AGQIVKILNNMVLFQTVHALSEALAIAVRAGIDG--DMLFDVFSKGSADSFAL................... 220
1142 0.003UniRef50_A0A1G0SDW4 Uncharacterized protein n=1 Tax=Ignavibacteria bacterium RIFCSPLOWO2_12_FULL_56_21 TaxID=1798438 RepID=A0A1G0SDW4_9BACT  ali  21  63.......................................................................................................................................EAVRTADLVILAAPSRTILRQL-SQVARSVKPDSIVTDVSSVKSEKLFRRGQFIGGHPMAGSERSGVSAADPLLF---ENALYVLTPSVSRARLNALARFLKAIGARVVVLRADVHDRVAAVVSQLTAVALMNVAGKRDRVA...................................................................... 211
1143 0.003UniRef50_F7V2Q4 3-Hydroxyacyl-CoA dehydrogenase n=1 Tax=Clostridium sp. (strain SY8519) TaxID=1042156 RepID=F7V2Q4_CLOSS  ali  19  68..............................................................................................................................NAKLFTDLTEALEDPDFVQESVPEEDLKRSIYKTIQDTLGNSPIILSTTSYFPSVLQQNASYPDRIFVT-------HPYNPSYLLP---LVEICNPIASEETMNQVLDFYTAMGKTPIVCKKEVDGYLVNNIAWQVLFTAMDLVEQGVCTVEDVDRAIMFGPGMRMAILGQIMCI--SLGIDGGI.................................... 243
1144 0.003UniRef50_A0A2T2XC43 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=Sulfobacillus benefaciens TaxID=453960 RepID=A0A2T2XC43_9FIRM  ali  16  37..............................................................................................LMSRHRESVDHLVTDGPFGLRRAVQRKKLTEEQVELTTDYAEAVAHSTVIIESVPEDAVKQAVFTEIEKHCAPDALIANTSSIMIGELAAHAAMPQ-------RFIGTHWFYPAHV--MKLVEVAVADHTSATSMERTQTLLKDWGKVPIVV..................................................................................................... 191
1145 0.003UniRef50_A9BJ19 Pyrroline-5-carboxylate reductase n=14 Tax=Bacteria TaxID=2 RepID=A9BJ19_PETMO  ali  13  50..............................................................................................................................DIKTISDNAKAVKESDIVLLAV-----KPQVIDKVLEEI---SSSCENKIVISIAAGVSLRHLDKALPTSSKIIRAMPNTPILV-GEGVIAISKKKNVDENDLKRVKEILESVGK-VYLVEEDIMDAITALSGSGPAYVYM-MIEALSDGGVLMGLPRELSTEFAARTLLGAARMVLETG......................................... 218
1146 0.003UniRef50_H0AE55 Prephenate dehydrogenase n=1 Tax=Haloredivivus sp. (strain G17) TaxID=1072681 RepID=H0AE55_HALSG  ali  10  7........................................................................................................................................................................................................EVLGMHPMYAPPIKGQKIVLCPEKGKKW-TLMETFWMDNGADIHVTEPESHDKAMSLVQGLMHFSELVVAETIRKADMTGSDMEEYSSPVYQLITDLTARMLQKPGLYGSIQSENP............................... 124
1147 0.003UniRef50_A0A086Y4T2 Prephenate dehydrogenase n=4 Tax=Alphaproteobacteria TaxID=28211 RepID=A0A086Y4T2_9RHOB  ali  14  82...................................................................................................................................................................HLRPGALVVDVCSVKLAPLQMLEELL-------PPHVALVGSHPLFGPRSPEARVVLCPARGGRGVAPLRRWLRQQGRRVLVRTAEVHDRDMALAQGVTHMV.................................................................................. 178
1148 0.003UniRef50_A0A2K9NZK8 Prephenate dehydrogenase n=1 Tax=Monoglobus pectinilyticus TaxID=1981510 RepID=A0A2K9NZK8_9FIRM  ali  18  59.......................................................................................................................................DAIENSD-VVFFCTYPDSIHKIIEINAHRFKTGAVISDVCGVKSSVS-------ESICSVLPEGVDYVGGHPMAGKEMDGFVYIITPVKTKESVELIREIAKYIGSRITIASPEEHDSVIAYTSDLMHIAASALCLSYPEKMN..................................................................... 207
1149 0.003UniRef50_A0A147HR62 Cyclohexadienyl dehydrogenase (Fragment) n=1 Tax=Sphingomonas endophytica TaxID=869719 RepID=A0A147HR62_9SPHN  ali  26  47.........................................................................................................................RVAELGIRVVATNVEAVRDADLVILCIPVGACGP-VAAEIAAHLKPGAIVSDPRAVKGAVVKDMAPHL-------PEGVHFVPAHP............................................................................................................................................ 126
1150 0.004UniRef50_A0A2R7Y9T5 Uncharacterized protein n=1 Tax=Aigarchaeota archaeon NZ13_MG1 TaxID=1980982 RepID=A0A2R7Y9T5_9ARCH  ali  17  41...........................................................................................................................KEVGTAASRSLEDAVRDADVTLVAVPPGS-TASVVVEASRYAKHGSVVVEVSSIKAHVIASLKRLRHTHAR-------LLSVHPLFGPGMRGKVVALVPIKSKSEMRIAKSLFDDA--KVVAVDWRTHDRAMAYVLSLSH-ALAVSLVFAMDNRTFRKAMGLSGTTFKLQILSAATSLSESPELMISAFKLNPYALRASSYRRKLGELSEVL............ 246
1151 0.004UniRef50_A0A239J5R3 3-hydroxyacyl-CoA dehydrogenase n=1 Tax=Anaerovirgula multivorans TaxID=312168 RepID=A0A239J5R3_9FIRM  ali  20  66...............................................................................................................................VKVTTDLIKAAECQLIIESINEDPDAKKELFARLGEICPEETVATNTSTIPIGKLGVAGGRLD-------KMIGLHFMWP--VPEMKLVEVIKNQDTSEETISLTTNLVKDMEKVPVVVK----DSPGFVSSRLIAVLINEAAEIYSQGI----ADAEAIDTIARLGLGFPARLCDKIGLDIIVDAFD................................ 240
1152 0.004UniRef50_A0A2U1RNH7 Prephenate dehydrogenase/arogenate dehydrogenase family protein n=3 Tax=candidate division NC10 TaxID=640293 RepID=A0A2U1RNH7_9BA  ali  19  79..........................................................................................................................................EGADMVLLAVPVGAITL-VLEQIVPHLAPGAVVTDVGSVKGVVAEAME-------RLVPEGHGV-PGHPIAGRETAGAKCILTPIHSTDALARVRALWRAMGSEALQMRPECHDEIFAAISHLPHIVAYALIG............................................................................ 215
1153 0.004UniRef50_A0A2E9TDJ5 Prephenate dehydrogenase n=1 Tax=Chloroflexi bacterium TaxID=2026724 RepID=A0A2E9TDJ5_9CHLR  ali  23  49....................................................................................................................................DDTEAIEDADLVVLAVPVLEI-PILMDNMAGWLKPGTAVTDTASTKTRVMEWAAEKM-------PDSVGFVGGHPLAGGGLSGQMFAGVSYAPEKCVKTVVEFVELLGATPRFVDVAEHDS.............................................................................................. 179
1154 0.004UniRef50_A0A271J0D7 Uncharacterized protein n=1 Tax=Rubrivirga marina TaxID=1196024 RepID=A0A271J0D7_9BACT  ali  17  55..................................................................................................................................TGSTAEVLASADLAVLATPL-DALPALMELAAAHVRPGALVTDVGSVKGAVLDAA--------RVLPQTVRFVGGHPMGGPEHADPLLFENAVWAAESAPEALWMVETAGARPVVLDADRHDLVAATISHLPQLLAVALVETFRDMTRIAGSPFSMWGPILRDNRTAVADVLASFGVGALRRSIDPTALASAFE--HAGQTRAALPSSSK....... 287
1155 0.005UniRef50_A0A1F9YVW0 Uncharacterized protein n=3 Tax=unclassified Euryarchaeota (miscellaneous) TaxID=115531 RepID=A0A1F9YVW0_9EURY  ali  12  115..............................................................................................................................GYRSVKSVRKVASESDLVVIASPLGVAAKEL-REVLRSSPQGTVF-DICSVKDHLAKDIKAAAGRGTR-------ITSVHPMFGPGVAGRNVLVCKCGCAGADREIVGLFSSAGAKVTKIGVDGHDELMAYVLGLPHLCTIAFASTAEKSRIPFAELARVQGPSFRLARSAIELSKESRRVYHDIQLLNPKSMEKALAELRFAALARDPEAFRTIIDRCEE 336
1156 0.005UniRef50_A0A0M3J5Z5 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (inferred by orthology to a human protein) n=5 Tax=Ecdysozoa TaxID=1206794 Re  ali  22  59.........................................................................TVVDRTD--AILEKAHAAIDKSVRRIAKK--KFADDT------KAQDAMVEDVHITMTTDIPQSVKEADLVIEAIVENTMKRNVFEQIEGASRTGTLLTNTSSIS-------LAEIAANLKRKSNFAGLHFFNP--VPVMKLLEVARYHETSDETFNTLMEFGKTIGKTTV....................................................................................................... 214
1157 0.005UniRef50_UPI000991CA90 3-hydroxyacyl-CoA dehydrogenase family protein n=1 Tax=Mycobacteroides salmoniphilum TaxID=404941 RepID=UPI000991CA90  ali  19  47..................................................................................................LRDAKEFIGEQLP-----ALLRTRPGSAQVEYTTDLASAVKNAWYIIESVPIPALKIDVLGQIDELAETDAIITNSSSYESSELIAKVTHPERVLNT----------HYGQPPEAPQLELMTDGHTDERIFDLLKQELVKYGFVVAAARKESVGFIVNRVWAAVKR------ESLAVIAEGVTTPQEFDQLWVAADFGKIGRLIDRVGLDVALDIEN................................ 248
1158 0.005UniRef50_A0A175A0B6 Prephenate dehydrogenase n=32 Tax=Bacteria TaxID=2 RepID=A0A175A0B6_CLOIN  ali  19  57.....................................................................................................................................DIDYIKEADIIISGL-YPNMTVDWITTYQKYFKPGALITDVSSVKTGVV-------EPIQKIIRRDVEFISSHPMAGKEVSGVKFLPTESNTKEAVATMRQFAEILGSNISELTVAQHDEMIGFVSHLTHAIAVSLMNTND......................................................................... 203
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Wyrwicz LS, Godzik A, Kloczkowski A, Rychlewski L. Support-vector-machine classification of linear functional motifs in proteins. J Mol Model 2006 Aug;12(4):453-61. Epub 2005 Dec 10.