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Query: IDP04224 gene: ipaC; IpaC, secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells [Shigella flexneri] CAC05802 [Shigella flexneri], from CSGID

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEIQNTKPTQTLYTDISTKQTQSSSETQKSQNYQQIAAHIPLNVGKNPVLTTTLNDDQLLKLSEQVQHDSEIIARLTDKKMKDLSEMSHTLTPENTLDISSLSSNAVSLIISVAVLLSALRTAETKLGSQLSLIAFDATKSAAENIVRQGLAALSSSITGAVTQVGITGIGAKKTHSGISDQKGALRKNLATAQSLEKELAGSKLGLNKQIDTNITSPQTNSSTKFLGKNKLAPDNISLSTEHKTSLSSPDISLQDKIDTQRRTYELNTLSAQQKQNIGRATMETSAVAGNISTSGGRYASALEEEEQLISQASSKQAEEASQVSKEASQATNQLIQKLLNIIDSINQSKNSAASQIAGNIRALast
1 -7.190[S] COG5280 Phage-related minor tail protein  ali follow..  10  1.........................................................................................................................................................MAKKISGITIAIGADTTGVTNGLKDIGKQSNSVNSELRDVERLLKLNPNNVELVAQKQQL--------------------SKQVELTTKKLDGLKGAQADVDRQFKSGDIGEEQYRAFQREVVATEGRLDHYKQSLKDVESSSGEAGNATKGLGGKFDELGQSVEDVGEAVKGGVLMEAADHLSVVGDKLKEFSGSAQEAFSDVDEGMDK 191
2 -6.780[S] COG5613 Uncharacterized conserved protein  ali follow..  11  143......................................................................................................................................NQEKIKETEENAKQVKKSGIASKIFGWLSAIASVIVGAIMVASGVGAVAGAMNMAVKQAAEDGLISQEAMKILGPI-EVALTVVSTVMTFGGSALKCLANIGAKLGANTASLVAKGAEFSAKVAQI-SFAGLTMSHAIRTGSQATQVAVGVGSGITQTINNKKQADLQHNNADLALNKADMAALQSIIDRLKEELSHLSESHQQVMELIFQMINAKGDMLHNLAGRPHT 400
3 -6.560[U] KOG3838 Mannose lectin ERGIC-53, involved in glycoprotein traffic  ali follow..  9  235.....................................................................................................................................................GISAATGGLADDVFHFLTTSLGQVQEQPKVENQEKLTQEYKEYQDKLEKQKQEYKKDHPDEHKDEEDWEEFYESENQRELRQIWQGQSQIADHLRELIIGRQETTLSLVSRNAGQALPPPAAGGVPQQQLPVGAVSRSDVDLLLTNQNMLLSSIREIRQLVGDINVRTDNIQTNQKHAPTAQIQSTGYDVQTLIAEMRDGMNQVKQGITHVGQR 459
4 -6.490[K] KOG1510 RNA polymerase II holoenzyme and mediator subcomplex, subunit SURB7/SRB7  ali follow..  11  54................................................................................................................................................................................................................................................................................DYAQLFAQLIARCAKDIDTLIESLPNEDSSIELQNSSLKRLEIE-NQGTARDLEEVVQKGELLLEKMQYSLECIAQAQLDMQITLKHDLQ. 142
5 -6.420[Q] COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component  ali follow..  8  20..........................................................................................................VGLLVVAVVIFGLVYGQFRGNFTPKSKLTMLADR-AGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAE-----TLDVYPRYLSLIPANVNADIKATTVFGGKYVSLTTPEHPSQKRLTPQTVIDARSVTTEINT---LFQTITLIAEKVDPIKLN--------LTLSAAAQSLAGLGERFGQSIVNGNSVLDDVNSQLPQARHDIQQL-ASLGDTYANSASDFFDFLNNSIVTSRTINQQQKDLDQVLLA.... 255
6 -6.280[R] COG1579 Zn-ribbon protein, possibly nucleic acid-binding  ali follow..  11  16.............................................................................................................................................................................IKMIRLMRVKKEHQKELAKVQSLKSDIRRKVQEKELEMENLKTQIRDGENRIQEISEQINKLENQQKMDEFNALTQEMTTANKERRSLE----------HQLSDLMDKQAGGEDLIVSLKESLASTENSSSVIEKEIFESIKKINEEGKALLEQRTELKHATNPELLSIYERLLNNKKDVVVPIENRV.. 198
7 -6.250[R] COG4980 Gas vesicle protein  ali follow..  10  32................................................................................................................................................................................................................................................................................QLREKMKTNYDSFEETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEIADIEEKIRQLEKTLQN.... 118
8 -6.010[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  8  650...........................................................................................................NIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQ--NLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDS------MIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQET-KELKNEIKALSEERTAIKEQLDSSNSTIAILQTEK-DKLELEITD 901
9 -5.960[D] KOG4438 Centromere-associated protein NUF2  ali follow..  8  204...............................................................................................................VLQEGNSQKKSNISEKTKRLNELKLLVVS------LKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGI-QQLKDAAEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAKID. 449
10 -5.910[S] COG5412 Phage-related protein  ali follow..  10  17................................................................................................................FRAGFQKAQESLANLQSRVNQTG-KRVQSIGKSISDLG-SKLTRNITVPAVGAATALTSITLVLVGIDSARAKLKGLGHDAEAIDSIMDSALASVKGTA-----------------------GLDEAATTAANAVAAGIPPGKELTRYLSLTADTAAIAGTSLGEIGAILNKVTTSGRAYNSELQMLSDRGLPVYQWLAEEANTTADAIFDMASKGEISTDMLLNAIEKNIGGAAKIGEESFSAAIANIGA 249
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24