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Query: IDP04225 gene: ipaB; IpaB, secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells [Shigella flexneri] CAC05803 [Shigella flexneri], from CSGID

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MHNVSTTTTGFPLAKILTSTELGDNTIQAANDAANKLFSLTIADLTANQNINTTNAHSTSNILIPELKAPKSLNASSQLTLLIGNLIQILGEKSLTALTNKITAWKSQQQARQQKNLEFSDKINTLLSETEGLTRDYEKQINKLKNADSKIKDLENKINQIQTRLSELDPESPEKKKLSREEIQLTIKKDAAVKDRTLIEQKTLSIHSKLTDKSMQLEKEIDSFSAFSNTASAEQLSTQQKSLTGLASVTQLMATFIQLVGKNNEESLKNDLALFQSLQESRKTEMERKSDEYAAEVRKAEELNRVMGCVGKILGALLTIVSVVAAAFSGGASLALAAVGLALMVTDAIVQAATGNSFMEQALNPIMKAVIEPLIKLLSDAFTKMLEGLGVDSKKAKMIGSILGAIAGALVLVAAVVLVATVGKQAAAKLAENIGKIIGKTLTDLIPKFLKNFSSQLDDLITNAVARLNKFLGAAGDEVISKQIISTHLNQAVLLGESVNSATQAGGSVASAVFQNSASTNLADLTLSKYQVEQLSKYISEAIEKFGQLQEVIADLLASMSNSQANRTDVAKAILQQTTALast
1 -19.100[S] COG5613 Uncharacterized conserved protein  ali follow..  18  109..............................................................................................................................................................................................................................................................ELGKLVSNLEEVRKDIKIADIQRLHEQNMKKIEENQEKIKETEENAKQVKKS-GIASKIFGWLSAIASVIV-----GAIMVASGVG-----------AVAGAMMVASGVIGMANMAVKQAAE--------------ISQEAMKILGPILTAIEVALTVVSTVMTFGGSALKCLANIGAKLGANTASLVAKGA-----EFSAKVAQISTGISNTVGSAVTKLGGS-FAGLTMSHAIRTGSQATQVAVGVGSGITQTINNKKQADLQHNNADLALNKADMAALQSIIDRLKEELSHLSESHQQVMELIFQMINAKGDMLHNLAGRPHT 400
2 -10.800[S] COG5280 Phage-related minor tail protein  ali follow..  12  1.................................................................................MAKKISGIT-GADTTGVTNGLKDIGKQSNSVNSELRDVERLLKLNPNNVELVAQKQQLLSKQVELTTKKLDGLKGAQADVDRQFKSGDIGEEQYRAFQREVVATEGRLDHYKQSLKDVESSSGEAGNATKGLGGKFDELGQSVEDVGEAVKGGVLMEAADHLSVVGDKLKEFSGSAQEAFSDVDEGMDKITTTTGKASDEFKTQFDN-VDSFEDVGSALGTLSAQFDMSGDTLEKNSKLALQYANINDTDVKTSIESAKSAIEVLDSVTATSRTGVAVDSLFDSAVK--GAPQIKDLGLNFSQGTELLGQFSKAGVDGDAALSSLSKASIIYAKG---NKSLSEGLGETIEKIKNAKTKQEALTEAATVTKGASRMVDAIQRGAFNLSELGDVAKKSNGTISDTFNKTVDDIDEQQIASQQAKVAMS-----FGAAIATGLKPL------LDLLVPLLKFLGQAFGSLPGPIKTILVVIGGLII............... 490
3 -9.900[S] COG5283 Phage-related tail protein  ali follow..  12  16......................................................................NETKAVEAINRLKSAVKDSTREDAVSASKYRYEGLSEAMEKQKAYIANLSEGMKTINRNTDAGEKAYQKYNAQLTTAERSLASMTGQLNRAKSAYEYQQTGIEDLNKSLSANDKLMQSQIDLYEKTRNKMGAAKAEVSGLSTSYAKQTEIYRAQVTELKRLEAAEGTSSETLVKQKTRV----NEAASSLMNYRNKLLEANLAVTKMQPFNSESLIGKGLNTVYQTTEKADVMAAGYQKVKSAAYQSAFGIAAIGAAAVKGAQMALVTGGEQAKEAQENVNKMYGKTQIADGYQELLPTMLQASFTDVVHNSTAALESFGMRSNDVKNTKEAVNQMAYAADMTATDFQNMGVAMEYVGASAHQSKLSLSETASAIAGTGLRKVIVSLQSPSKDAAEALSGSTKDFVDQNGNMKSMTEIFGLLNQHTEKLSSFQKG--QIFHALFGTTGQQAGAILSENVKQLGELDDKVKKSADGQGYVVNLANKNMQSTQNELKQFKAAGEAVLIMI.. 593
4 -8.820[S] COG5412 Phage-related protein  ali follow..  8  99..................................DAEAIDSIMDSALASVKGTAFGLDEAATTAANAVA-AGIPPGKELTRYLSLTADTAAIAG-TSLGEIGAILNKVTTSGRAYNSELQMLSDRGLPVYQWLAEEANTTADAIFDMASKGEISTDMLLNAIEKNIGGAAKIMGEESFSAAIANIGADIARIGANFLDAGGKAGGFFSTVKPLLTEFRGFLAQVEEQAADWGVAFGQAFNNVIDRVRELKSWFDGLSPSVQTLITRAVAIGAGFLVGIGPALKV-VGFLTTQFGSLLNITSLLLSPIGLVVVGITGLAVAFGVAMAKSEEFRNLVFGVFQNLASIISTVIATVSP-DGAREGLASFAETVLINAFELIVTVLQTVVVAVEFVSSFIQGFQSAGGEVTSLSSLFLGFNPVLSMALLILQEFGPQIAQGFSQIASMALGQTLGELAAAIIPMVMNVISALMPVVMSLGMTIMDLAIIPILIDVFSQLLPIITQLVTTFAGIIAQVAPLVTILVSSLVPVLMILIETVLNIVQAVAPALIAILGAVASAFDAIIPVVMAVLSTVVNVVANI.. 656
5 -8.710[U] KOG4809 Rab6 GTPase-interacting protein involved in endosome-to-TGN transport  ali follow..  9  388...........................................................................................DSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL--EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS----------LLQGDLSEKEASLLDLKEHASSLASSGLK-----KDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRKAQAEVDRLLEIL--KEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSA--QMLEEARRREDNLNDSSQQLQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS 868
6 -8.310[R] COG1579 Zn-ribbon protein, possibly nucleic acid-binding  ali follow..  15  1.................................................................................MHDALLSIL---AIQELDIKMIRLMRVKKEHQKELAKVQSLKSDIRRKVQEKELEMENLKTQIRDGENRIQEISEQINKLENQQAAVKKM--------DEFNALTQEMTTANKERRSLEHQLSDLMDKQAGGEDLIVSLKESLASTENSSSVIEKEIFESIKKINEEGKALLEQRTELKHATNPELLSIYERLLNNKKDRVVVPIENRVPQHENLVRKKDRLIFCEHC-SRIL.......................................................................................................................................................................................................................................................................... 230
7 -7.890[R] KOG4331 Polytopic membrane protein Prominin  ali follow..  10  160.............................................................................VSANAFVAFTLLMTSQYAQIMNQCVDDLQSYKRDSDMRIRKLIDDYQVLNSTITKQLSTAGYNVVD----------KKLTGAHVIDVFMNISKVAQEMHDGLESVHGKVRFLNEEGSRFEAEFSRLRNTANEELVKCLENELEPVRSMCAKAERLLESLAVTQFKIDQKFLPDATETGLSEIVNANITQVLAASNNQFEQLESRIQHEIDKETYSAQNMLKQIGDFGVLYGICGRLIFVFLAVGTSALMFAVGNFSNLVEVTLQSKSPAEIIRACSRNETLYNFYFDKKYH--LNKLQDFLRTTMENMPEIRPLDAFISRSELRDLEKLASVNVSKVSQQGLNAIKHAMDELDLASKTREFEESLDANRPKAVTLVLEQIRELEIQFAKPLRSRLEALYSNITSLDEKLSQLQVPVSSLLVKLQHAQALLAENMREHFGRAAKEEFQ-----QMVNNIDQYIVHVKSQMESEVTSCQPLTQIARQTTA............... 778
8 -7.790[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  9  666LEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIG-----RLREEIEELKRNQELL--QSQLTEKDSMIENMKSSQTSGTNE-QSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLDHI..................................................................................................................................................................................................................................................................................... 962
9 -7.790[D] COG3096 Uncharacterized protein involved in chromosome partitioning  ali follow..  13  418.............................................................................QAIAALNRAKELCHLPDLTA--DCAAEWLETFQAKELEATEKMLSLEQKMSMAQTAHSQFEQAYQLVVAINVDQRHLAEQVQPLRMRLSELEQRLREQQEAERLLADFEALHQELEARIASLSDSVSNAREERMALRQEQEQLQSRIQSLMQRAPNQLSEQCGEEFTSSQDVTEYLQQLLE-----REREAIVERDEVGARKNAVDEEIERLSQPGGSEDQRLNALAERFG--GVLLSEIYDDVSLEDAPY---FSALYGPSRHAIVVPDQVTEHLEGLTYSRFPEVPLFESRIESLTQRLHQAFSRFIGS---PEAEIRQLNSRRVELERALSNHENDNQQQRIQFEQAKEGVTALNRILPRL-DDSLADRVDEIRERLDEA-GNQLAKLEPIVSVLQSDPEQFEQLKEDYAYSQQMQRDARQQAFALTEVVQRRAHFSYSDSAEMLSGNSDLNEKLRERLEQAEAERTRAREALRGHAAQLSQYNQVLASLKSSYDTKKEL 1034
10 -7.580[S] COG4913 Uncharacterized protein conserved in bacteria  ali follow..  9  235..................................................................LEPCDVGSRIEALICHFDDLDRA--HQAVLTAKQQVKLLVPLVDDVQKHQTQLASRPYFAQLKGELLKHRLDALAAEAAQLTVEIQHLEEQRKAADSEVTQLDNGGDRLEELAAEIEQLEQAKAQRQKKSDRYQTLLTKIDETAPADAIGFLTQQQRFAQHTEELNAAIERLHNDKSEKDRALYDAREKHTTL--LAEINSLQQRQSNISAAQIRIRHDLCMALSIDAEALPFAGE--------------LIQVRKEDARNWEGAAERLLHGFGLTLLVPDAHYKAVA--TWVNNQ-QALVHKLIIKPESPHYTWLQQELQRRC---DTIEQFHCEARAITQAGQIKDPSGRHEKDDRHRIDDRSRYVLGWSNADKLHTLNAQRQHLEDSMGM-LGQDIGTIQRECQKQQERLDALNKLGEYPEFADIDWMSLVRQIA------------GRKKEQEQLQATSNILQTLQQQLTAAQTQVSVLERKCKNAWHEQGEVKSQQKTAQQMW...... 750
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Dunbrack RL Jr, Dunker K, Godzik A. Protein structure prediction in biology and medicine. Pac Symp Biocomput. 2000;(12):93-4.