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Query: IDP00425 gene: wecC; UDP-N-acetyl-D-mannosamine dehydrogenase YPO3863 [Yersinia pestis CO92], from CSGID

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSFETISVIGLGYIGLPTAAAFASRKKKVIGVDVNAHAVETINRGAIHIVEPDLDKVVKIAVEGGYLQAVTKPQAADAFLIAVPTPFKGDHEPDMIFVESAAKSIAPVLKKGDLVILESTSPVGATEQMAQWLAEARPDLSFPQQAGEAADINIAYCPERVLPGQVMVELIQNDRVIGGMTPKCSARASALYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICDEQGINVWELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVSQNPQLARLIHTARLVNDGKPLWVVDRVKAAVADCLAASDKRASEVKIACFGLAFKPDIDDLRESPAVGVARLIAEWHVGETLVVEPNVEQLPKSLMGLVTLKDTATALQQADVLVMLVDHKQFKAIKPEDIKQQWIVDTKGVWRLast
1 -106.000IDP00425 gene: wecC; UDP-N-acetyl-D-mannosamine dehydrogenase YPO3863 [Yersinia pestis CO92]  ali  100  1MSFETISVIGLGYIGLPTAAAFASRKKKVIGVDVNAHAVETINRGAIHIVEPDLDKVVKIAVEGGYLQAVTKPQAADAFLIAVPTPFKGDHEPDMIFVESAAKSIAPVLKKGDLVILESTSPVGATEQMAQWLAEARPDLSFPQQAGEAADINIAYCPERVLPGQVMVELIQNDRVIGGMTPKCSARASALYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICDEQGINVWELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVSQNPQLARLIHTARLVNDGKPLWVVDRVKAAVADCLAASDKRASEVKIACFGLAFKPDIDDLRESPAVGVARLIAEWHVGETLVVEPNVEQLPKSLMGLVTLKDTATALQQADVLVMLVDHKQFKAIKPEDIKQQWIVDTKGVWR 420
2 -99.500IDP01406 gene: wecC; UDP-N-acetyl-D-mannosamine dehydrogenase VC0918 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  65  2..FNKVSVIGLGYIGLPTAAVLASRGLDVVGVDVNAHAVDTINKGEIHIVEPDLDIVVRSAVMTGKLKATLTAEPADAFLVAVPTPFKGDNEPDLSYIEAAAKTIAPVLAKGNLVVLESTSPVGTTEKLAQWLAEARPDLTFPQQKGIAADVKIAYCPERVLPGYVLQELVSNDRVIGGVSKACSEKAVALYKTFVKGECIVTNARTAEMAKLTENSFRDVNIAFANELSLVCNKLKINVWELIRLANRHPRVSILNPGPGVGGHCIAVDPWFIVNSCPDEAQLIRTAREVNDGKPHWVVDQVKQAADQ--------FKKPIIACLGLAFKADIDDLRESPALDITKHLAESKVGQLLAVEPNITELPSKLAKGIELVSLERALELANIVVVLVDHKEFKAADKTEFAKKVVIDTRGVVA 413
3 -95.000IDP00702 gene: cap5O; capsular polysaccharide biosynthesis protein Cap5O SACOL0150 [Staphylococcus aureus subsp. aureus COL]  ali follow..  42  1...MKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQSGQISIEEPGLQEVYEEVLSSGKLKVSTTPDASDVFIIAVPTPNNDDQSCDISLVMRALDSILSFLEKGNTIIVESTIAPKTMDDFVKPVIEN-------LGFTIGEDIYLVHCPERVLPGKILEELVHNNRIIGGVTEACIEAGKRVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMANKHPRVNIHQPGPGVGGHCLAVDPYFIIAKDPENAKLIQTGREINNSMPAYVVDTTKQII--------KVLSGNKVTVFGLTYKGDVDDIRESPAFDIYELLNQEPDIEVCAYDPHVELDFVE-------HDMSHAVKDASLVLILSDHSEFKNLSFDKMKHKVIFDTKNVVK 400
4 -94.200IDP01235 gene: wecC; UDP-N-acetyl-D-mannosamine dehydrogenase BA_5512 [Bacillus anthracis str. Ames]  ali follow..  42  1...MKICTMGLGYIGLPTSAMFAKYGTEVVGVDIHQKVVDKLNNGEIHIEEPGLGEVVKEVVANGKFRASLTPEEADAFIISVPTPNHDDKSCDLSYVLTATEKVLPFVKKGNVIIVESTIAPRSMDDYVKPLVEE-------AGFTVGEDIYLVHCPERVLPGQILHELVHNNRIVGGVTPACAEAGARVYGVFVEGEIIKTNAKTAEMSKLMENTFRDVNIALANELTKVCNSLDINVLDVIEMANKHPRVNLHYPGPGVGGHCLAVDPYFIVAKAPELANIIKLSRETNVSMPHYVTEKVKELLAG--------VENPKVAAFGVTYKGNVDDMRESPAMDVIDLIRNEG-ITVSAHDPHVES------DFFELHSAEEAVKDAHLILVLTDHDEFKTMNYDSLAKTVVFDTRNCVQ 401
5 -87.300IDP04467 putative nucleotide sugar dehydrogenase [Yersinia pestis CO92] YPO2174 [Yersinia pestis CO92]  ali follow..  24  1...MKVTVFGIGYVGLVQATVLAEVGHDVLCIDIDANKVADLKKGRIAIFEPGLAPLVKENYEAGRLQFSTDVAHGVIQFIAVGTPPDEDGAADLKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKVHQVIQAILEQRG------EKIDFSVVSNPEFLKEGAAVADCKRPERIVIGIDTDALELISELYEPFNRNRMLVMDIRSAELTKYAANGMLATKISFMNEIANIAERLGADIEKVRQGIGSDSRIGFIYSGCGYGGSCFPKDIQALIRTAEDKGQLLQAVEQINNQQKYKLTEFIKSHF-------NSQLAGKTFAVWGLAFKPNTDDMREAPSRVVMESLWEAG-ATIQAYDPEAMDETQRIYGLRLMGTKESALQGADALIICTEWQSFRAPDFDMIKHPVIFDGRNLYD 425
6 -77.000IDP95261 WecC protein [Acinetobacter baumannii ATCC 17978] YP_001083149 [Acinetobacter baumannii ATCC 17978]  ali follow..  25  1......................................................................................MDQVNRPDLTPLKKASETVGQALKKGDIVVYESTVYPGATEEVCIPILEKVSGLK------FNQDFFAGYSPERINPGDKVNTLTKIKKITSGSTPEVANTVDAVYASIITGTHKASSIKVAEAAKVIENTQRDLNIALVNELSVIFDRIGIDTLDVLEAAGSKWNFLPFRPG-LVGGHCIGVDPYYLTHKAEEVGQVILAGRRINDNMARYVARNTIKLM----LQNGIDVPRSKVGVLGVTFKENCPDIRNSKVADLIKELEFWG-AQVVVADPWADAEEVKH-EYGVELGTVNAQNPVDSLIVAVGHSEFRSLSASELRSPVLADVKSLFD 331
7 -76.000IDP01494 UDP-glucose 6-dehydrogenase VCA0780 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  21  1...MKIAIAGTGYVGLSNGILLAQ-HNEVVALDIVVSRVEQLNDKISPIADPEIESFLQHQP--LNFRATCDYQDAQFVVIATPTDYDPQTHFDTRTVEAVIDDVLA-INPQAIMVIKSTVPVGYTKRIKQRLCC----------------NNLIFSPEFLREGRALYDNLYPSRIIVGESERGQAFATLLAQGAKKMPILLTHSTEAEAVKLFSNTYLAMRVSFFNELDTYAETHGLDTKQIIEGVGLDPRIGYNNPSFGYGGYCLPKDTRQLLRNFEDVPNLIRAIVDANTTRKDHIAFSILN------------RNPKVVGIYRLIMKSGSDNFRASSILGIMKRIKAQG-VEVVIYEPVLNESTFY--GSPVIRDLAQFKAMAEVIVTNRRVAELEDVAE-------KIYTRDLFG 386
8 -74.300IDP01969 gene: kfiD; putative UDP-glucose 6-dehydrogenase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj1441c [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  20  1...MKIVIVGIGYVGLANAILFSKNNNEVVLLDIDENKIQSINNHKSPIKDKLIEKFFVQNI--SKLHATSNYFNADFAVIATPTDYDEQLNFDTRSIENVLKDIKN-INSKINVIIKSTVPIGYTKTIKQKF----------------NMSNIVFSPEFLREGSALYDSLYPSRIIIGDKSVGKTIGDLFLKNIEKKDIFYMDSDEAESVKLFSNTYLAMRVGFFNEVDSYARKHNLNSADIIKGISADDRIGYNNPSFGYGGYCLPKDTKQLLANFYNINSLIKAIVETNEIRKKFITQLILE------------KKPNILGIYRLIMKQNSDNFRNSVIIDIIKYLQEYNSIELIIYEPLVKEKKFL--NIKVENDFNVFGAKVDLIIANRFDDKLKEIK-DKVFSADVFY-TDI.. 393
9 -19.400IDP06064 3-hydroxyacid dehydrogenase [Helicobacter pylori J99] NP_223303 [Helicobacter pylori J99]  ali follow..  10  1...MKIGWIGLGAMGTPMATRLRDAGLEVSVYNRTESKAAPLKEKGVAVYT----------------SPIDLAAKVDLVFTMLSDK---------AAIDAVLAPKFWEQMSKKIVVNMSTIAPLESLSLEKIAQKHQATY---------LEAPVSGSVGAAKAGALL--------ILAAGDEEVISKLKPVLAHLGSQTFYLGKVGQGTGAKLSINSLLAQMGVAYSEALLLAKRLGVDAESFLQIIG............................................................................................................................................................................ 203
10 -14.200IDP06299 6-phosphogluconate dehydrogenase [Streptococcus pneumoniae TIGR4] NP_344902 [Streptococcus pneumoniae TIGR4]  ali follow..  9  1MTKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKT---------------EDVIACHPEKNFVPSYD-VNSIEKPRRIMLMV------QAGPGTDATIQALLPHLDKGDILIDGGNTFYKDTIRRNEELANSGINF---------IGTGVSGGEKGALEGPS---------IMPGGQKEAYELVADVLEEISAKATYIGPDGAGHYVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAEIEITADILSRKDDEGQDGPIVDYILDAAGNKGTGKWTSQSSIEKIRQALYFSKIISYAQGFAQLRVASKENNWNLPFADIASIWRDGC--IRSRFLQKITDAYNRDADLANLLLDEYFLDVTAKYQQAVRDIVALAVQAGVPVPTFSAAITYFDSYRSADLPANLIQAQRDYF. 452
11 -13.600IDP02226 gene: yqjI; 6-phosphogluconate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA0164 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  15  1MENLQIGVVGVGVMGKSLALNFESKGYSVALYDISKEKVDET-------IEENRGKNLVGTHIVEEF-----VNSLESPRKILLMV------NAGEITDKAIDSLVPHLDKGDILIDGGNTYFVDTIRRNKRLAEEGINF---------IGAGVSGGEEGALKGPS---------IMPGGQKDAYEKVKDMLENISAKVSYIGPNGAGHYVKMVHNGIEYGDMQLICEAYFFLKQTLDEFHEIFAEWN............................................................................................................................................................................ 222
12 -12.200IDP02330 gene: ilvC-1; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1419 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  14  15LKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTV-----------------AEAAKQADVVMILLP---------DELQPEVYEEEIAPNLQAGNSLVFAH----GFNVHFDQVKPPVNVDVFLVAPKGPGHLV------RTFSEGGAVPALFA---VYQDATGVATEKALSYADGIGATRAGVLETTFKEETETEQAVLCGGVTALVKAGFETLVDAGYQPELAYFEC............................................................................................................................................................................. 227
13 -10.800IDP02668 gene: gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA1526 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  11  1..MTKITVVGAGSWGTALAMVLADNGHDVRIWGNRSELMDEINTKHEN------SRYLPGITLPSTIVAYSSLEEANVVLIVVPT----------KAYREVLQDMKKYVAGPTTWIHASKIEPGTSKRISEVIEEEIPE-------DLIKDVVVLSGPSHAEE---VGLRQATTVTSAAKRMEAAEEVQDLFMNSYFRVYTNPDIVGVELGGALKNII-ALAAGITNAKAALMTRGLTEIARLGRKMGGNPLTFAGLTGMG--GNMLGKGHSLVLESMGMVVEGVRTTKAAHELAEKMEVEMPITAALYDVLFNGNNVKDAVGSLMGRVRKHEVEAIPD................................................................................. 338
14 -10.400IDP01976 gene: gpsA; glycerol-3-phosphate dehydrogenase (NAD+) [Coxiella burnetii RSA 493] CBU_1518 [Coxiella burnetii RSA 493]  ali follow..  11  4.FKHPIAILGAGSWGTALALVLARKGQKVRLWSYESDHVDEMQAEGVN------NRYLPNYPFPETLKAYCDLKASTDILIVVPS----------FAFHEVITRMKPLIDAKTRIAWGTKGLAKGSRLLHEVVATELGQ----------VPMAVISGPSLATE---VAANLPTAVSLASNNSQFSKDLIERLHGQRFRVYKNDDMIGVELCGSVKNIL-AIATGISNARAALITRGLTEMGRLVSVFGGKQETLTGLAGLG............................................................................................................................................................... 244
15 -10.400IDP90757 gene: ilvC; ketol-acid reductoisomerase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj0632 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  12  16IKSKKVAIIGFGSQGHAHAMNLRDNGVNVTIGLREGSVSAVK----------------AKNAGFEVVSVSEASKIADVIMILAP---------DEIQADIFNVEIKPNLSEGKAIAFAHGFNIHYGQIVVPKGVDV---------IMIAPKAPGHTVRNEFTLGGGTPCLIAIHQDESKNAKNLALSYASAIGGGRTGIIETTFKAETETDLFGEQAVLCGGLALIQAGFETLVEAGYEPEMAYFEC............................................................................................................................................................................. 229
16 -10.400IDP04504 2-dehydropantoate 2-reductase [Vibrio cholerae O1 biovar eltor str. N16961] VC2307 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  15  1...MNIVVLGPGAVGSLWALHLHSAGHQVALWSRQAQPTITLQLDEEAPISFRNQN-------------LDTLIHADLLLITVKA-----------QVEAALQPLLPHLNRETILLFMHN--MGAVEAISESLTHFPFATTTHGALKATLNQVSHTGFGQTQVGPFNALGARCDFIADVFNHANPEIQQALWRKLAVNCAILTAIHQCANGALVAPEFTPIITAILDEVTAVMQAEAISG.................................................................................................................................................................................... 223
17 -10.200IDP01730 gene: gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [Francisella tularensis subsp. tularensis SCHU S4] FTT0871 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  14  2..QKNILVLGAGAWGTALALQLAYRGHNVRINSWKAEHNEQMLKNNNHKYLPSIEKFPSRLKAIQDWQAN--IIEFDSILVATPS----------SGFKNTILELKECILPQQNIISATKGFCHDSYALLSEIAEDILP---------TTKFALLTGPSFAKE---LANQLPTAVVVASKDINYARYVQELFSNENFRCYTTTDIIGAQVGGAVKNVL-AITAGIANAHAALITRGLAEIKKLGLKLGANSETFIGLSCLG............................................................................................................................................................... 243
18 -9.630IDP02524 gene: ilvC-2; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1852 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  11  14LQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGFEVMS-----------------VSEAVRTAQVVQMLLP---------DEQQAHVYKAEVEENLREGQMLLFSH----GFNIHFGQINPPSYVDVAMVAPKSPGHLV------RVFQEGNGVPALVA---VHQDATGTALHVALAYAKGVGCTRAGVIETTFQEETETEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEG-------TNMRHSISDTAEFGDYVTGSRIVTDETKKEMKRVLTEIQQGEFAKK-KAEQNHQLEKVGEELREMMSWIHAPKELV............................................................................ 333
19 -9.500IDP05101 gene: hbd; 3-hydroxybutyryl-CoA dehydrogenase [Clostridium difficile 630] CD1058 [Peptoclostridium difficile 630]  ali follow..  15  1...MKLAVIGSGTMGSGIVQTFASCGHDVCLKSRTQGAIDKLDKNLTKLVTKGKMDEATKAEILSHVSSTTNLKDMDLIIEASVE--------DMNIKKDVFKLLDELCKEDTILATNTSSLSITEIASSTKRPDKVIGMHF-------------FNP----------PMMKLVEVISGTSKVTFDTVFELSKSINKVPVDVSESPGFVVNRIL--------IPMINEAVGIYADGVASKEEIDEAMKL--------------GANHPMGPLALG................................................................................................................................................. 229
20 -9.100IDP02372 gene: mdh; lactate dehydrogenase [Francisella tularensis subsp. tularensis SCHU S4] FTT0535c [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  11  1MARKKITLVGAGNIGGTLAHLALIKQLDVVLFDIAQGMPNGKALDLLQ-----TCPIEGVDFKVRGTNDYKDLENSDVVIVTAGVPRKPGMSINIKVMQTVGEGIKHNCPNAFVICITNPL------DIMVNMLQKFSGVPDNKIVGMAGVLDSARFRTFLADGDTMVPLTKMSN-VAGVSLEQLVKEGKLKQERLDAIVSRTRSGGGEIVALLKTGSAYYAPAAA--GIQMAESFLKDKKMILPCAGLDEDLFVGVP-ISANG----VRPIEVEISDKEREQLQVSINAIKD-----LNKAAAEILAK............................................................................................................... 319
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.