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Query: IDP90565 ketol-acid reductoisomerase [Vibrio cholerae O1 biovar eltor str. N16961] VC0162 [Vibrio cholerae O1 biovar El Tor str. N16961], from CSGID

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MANYFNTLNLREQLDQLGRCRFMAREEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVSYALRQAAIDEQRQSFKNAKNNGFNVGSYEQLIPTADLVINLTPDKQHTSVVNAVMPLMKQGAALGYSHGFNIVEEGMQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPQGEGWEIAKAWAAATGGHRAGCLASSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKMVADGIDPGYAGKLLQFGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDLMRPLYNKHMDDIISGHFSSTMMADWANDDKDLFGWRAETAETAFENYPTTDVKIAEQEYFDNGILMIAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANTVARKRLYEMNVVISDTAEYGNYLFANVAVPLLREKFMPKVGTDVIGKGLGVVSNQVDNATLIEVNSIIRNHPVEYIGEELRGYMKDMKRIAVGDLast
1 -122.000IDP90565 ketol-acid reductoisomerase [Vibrio cholerae O1 biovar eltor str. N16961] VC0162 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali  100  1MANYFNTLNLREQLDQLGRCRFMAREEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVSYALRQAAIDEQRQSFKNAKNNGFNVGSYEQLIPTADLVINLTPDKQHTSVVNAVMPLMKQGAALGYSHGFNIVEEGMQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPQGEGWEIAKAWAAATGGHRAGCLASSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKMVADGIDPGYAGKLLQFGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDLMRPLYNKHMDDIISGHFSSTMMADWANDDKDLFGWRAETAETAFENYPTTDVKIAEQEYFDNGILMIAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANTVARKRLYEMNVVISDTAEYGNYLFANVAVPLLREKFMPKVGTDVIGKGLGVVSNQVDNATLIEVNSIIRNHPVEYIGEELRGYMKDMKRIAVGD 494
2 -59.400IDP90757 gene: ilvC; ketol-acid reductoisomerase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj0632 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  30  1......................MAITVYDCDLNLIKSKKVAIIGFGSQGHAHAMNLRDNGVNVTIGLR-----EGSVSAVKAKNAGFEVVSVSEASKIADVIMILAPDEIQADIFVEIKPNLSEGKAIAFAHGFNIHYGQIVVPKGVDVIMIAPKAPGHTVRNEFTLGGGTPCLIAIH--QDESKNAKNLALSYASAIGGGRTGIIETTFKAETETD----------------------------------------------------------------------------------------------------------------------------------------LFGEQAVLCGGLSALIQAGFETLVEAGYEPEMAYFECLHEMKLIVDLIYQGGIADMRYSISNTAEYGDYITGPKIITEETKKAMKGVLKDIQNGVFAKDERRAGFARMHAERKNMNDSLIEKTGRNLRAMMPWISAKKLVD 336
3 -58.100IDP02524 gene: ilvC-2; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1852 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  35  1MKTYYEQ---------------------DANVGLLQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVR------PGKSFEVAKADGFEVMSVSEAVRTAQVVQMLLPDEQQAHVYAEVEENLREGQMLLFSHGFNIHFGQINPPSYVDVAMVAPKSPGHLVRRVFQEGNGVPALVAVH--QDATGTALHVALAYAKGVGCTRAGVIETTFQEETETD----------------------------------------------------------------------------------------------------------------------------------------LFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEGGLTNMRHSISDTAEFGDYVTGSRIVTDETKKEMKRVLTEIQQGEFAKKENQAGRPTYNAMKKAEQNHQLEKVGEELREMMSWIHAPKELV 333
4 -56.900IDP02330 gene: ilvC-1; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1419 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  31  1......................MAKVYYEKDVTVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLR------KGKSWDKAKEDGFSVYTVAEAAKQADVVMILLPDELQPEVYEEIAPNLQAGNSLVFAHGFNVHFDQVKPPVNVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVY--QDATGVATEKALSYADGIGATRAGVLETTFKEETETDLFG----------------------------------------------------------------------------------------------------------------------------------------EQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYEGGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGTVLAEIQDGTFARGEHKAGKPNFYATNEKENEHEIEVVGRKLRGMMPFVQPRVKAG 334
5 -29.500IDP00140 pyrroline-5-carboxylate reductase, putative BA_0197 [Bacillus anthracis str. Ames]  ali follow..  10  1.................................MLTKHRILFIGAGRMAEAIFSGLLKTSKEYIEEIIVSNRSNVEKLDQLRARYNVSTTDWKQHVTSVDTIVLAMPPSAHEELLAELSPLLSNQLVVTVAAGISPSYLEERLPGGTPVAWIMPNTAAEI-------GKSIS---LYTMGQFVNETHQETLQLLLRGIGTS------QLCTEEEVHQLTAVTGSAPAFLYYFAESLIEATKSYGVDEATAKHLVIQMISGSASML-EQTQDPANLREQVTTPGGSTAEGLKAL......................................................................................................................................................................................................... 244
6 -27.600IDP02492 gene: proC; pyrroline-5-carboxylate reductase [Francisella tularensis subsp. tularensis SCHU S4] FTT1559c [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  12  1.....................................MKICFIGGGNMAAAMIAGMTSHGYKSQ--IIVFDRNEHKCLNLIKKYNINTSTSLLNTIKLADVLILAIKPQNMFELIKNIRDTVTSTQVIVVAAGIQTSAYEELFNKEISFARTIPNTPSSL-------GYGAT---GIFFNKVIAADKKDLVIDIMQTMGVV------TVVEDEKEIDVAAIASSGPAYYFQFMEHMVEAAIKQGLDKKQAEKLVVQTCLGAAQMALNTNENMSELRKNVTSKKGITYEALNIFE--QFNLGGIVDKAIQANIARA................................................................................................................................................................................... 261
7 -27.500IDP02179 gene: proC; pyrroline-5-carboxylate reductase [Coxiella burnetii RSA 493] CBU_2090 [Coxiella burnetii RSA 493]  ali follow..  11  1..................................MNTSNITFIGGGNMARNIVVGLIANGYDPN--ICVTNRSLDKLDFFKEKCGVHTTQDNRQGALNADVVVLAVKPHQIKMVCEELKDILSETKILVISVGVTTPLIEKWLGKASRIVRAMPNTPSSV-------RAGAT---GLFANETVDKDQKNLAESIMRAVGLV------IWVSSEDQIEIAALSGSGPAYIFLIMEALQEAAEQLGLTKETAELLTEQTVLGAARMALETEQSVVQLRQFVTSPGGTTEQAIKVLE--SGNLRELFIKALTAAVNRA................................................................................................................................................................................... 265
8 -13.600IDP06064 3-hydroxyacid dehydrogenase [Helicobacter pylori J99] NP_223303 [Helicobacter pylori J99]  ali follow..  15  1.....................................MKIGWIGLGAMGTPMATRLRDAGLEVSVYNR-----TESKAAPLKEKGVAVYTSPIDLAAKVDLVFTMLSDAAIDAVLAPKFWEQMSKKIVV-------NMSTIAPLESLSLEKIAQKHQATYLEAPVSGSVGAAKAGALLILAAGDEEVISKLKPVLAHLGSQTFYLGKVGQGTGAKL----SINSLLAQMGVAYSEALLLAKRLGVDAESFLQII................................................................................................................................................................................................................................................ 202
9 -12.400IDP06299 6-phosphogluconate dehydrogenase [Streptococcus pneumoniae TIGR4] NP_344902 [Streptococcus pneumoniae TIGR4]  ali follow..  10  1..................................MTKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKTED--IACHPEKNFVPSYDVESFVNSIEKPRRIMLMVQAGPGTQALLPHLDKGDILITFYKDTIRRNEELANSGINFIGT-------------VSGGEKGALEGPSIMPGGQKEAYELVADVLEEISAKAPEDGKPCVTYAGHYVKMVHNGIEYGDMQLIAES-YDLMQHLLGLSAEDMAEIFTEWNKLDSYLIEITADILSRKDDEGQDGPIVDYILDAAGNKGTGKWTSQSSLDLGVPLSLITESVFARYISTYKEERVHASKVLPKPAAFNFEGDKAELIERQALYFSKIISYAQ-GFAQLRVA--SKENNWNLPFADIASIWRIIRSRFLQKITDAYNRDADLANLLLDEYFLDVTAKYQQAPTFSAAITYFDSYRSADLPANLIQAQRDYFGAHTYQRKDKEGTFHYSWYDEK.... 474
10 -11.800IDP95479 S-adenosylhomocysteinase Q5CPH1 [Cryptosporidium parvum]  ali follow..  21  232AINVNDSVTKSKFDNTYGCRQSLLHGLFNGCIQMLAGKKIVVLGYGEVGKGCAQGLSGVGARVIV------TEIDPICALQASMEGYQVSVLEDVVSEADIFITATGNK--DVITVEHMRKMKENAYIANIGHFD....................................................................................................................................................................................................................................................................................................................................................................... 358
11 -11.600IDP04504 2-dehydropantoate 2-reductase [Vibrio cholerae O1 biovar eltor str. N16961] VC2307 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  15  1.....................................MNIVVLGPGAVGSLWALHLHSAGHQVALWSR------QAQPTITLQLDEEAPISFRDTLIHADLLLITVKAWQVEAALQPLLPHLNRETLLFMHNGMGAVEAISESLTHFPVLFATTTHGALKATLNQVSHTGFGQTQ-VGPFNALGARCDFIADVFNHA--------APVTWNPEIQQALWRKLAVNCAILTAIHQ------CANGLVAPEFTPIITAILDEVTAVMQAEAISGEAEALRDGVY--------QVIQATAANLSSMHQDVFHRRPTE.................................................................................................................................................................................... 257
12 -11.500IDP02226 gene: yqjI; 6-phosphogluconate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA0164 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  9  1..................................MENLQIGVVGVGVMGKSLALNFESKGYSVALYDISKEKVDE--IEENRGKNLVGTHIVEEFVNSLESPRKILLMEITDKAIDSLVPHLDKGDILITYFVDTIRRNKRLAEEGINFIGA-------------VSGGEEGALKGPSIMPGGQKDAYEKVKDMLENISAKVNNCSYIGPNGAGHYVKMVHNGIEYGDMQLICEA-YFFLKQTLDLTAEEFHEIFAEWNKGELNSYLIEITADIFKKKDEETGKPLVDVILDTAGQKGTGKWTSQSALDLGISLPIITESSALKEERVNASKVLSGPKDKTAIGVEKAELIEAV--RQALYMSKICSYAQ-GFTQLKAA--SEEYNWNLDFGSISMLWRIIRAAFLQNIKEAYETNTDLPNLLLDPYFKEIVESYQGGPAFSAAISYYDSYRTAKLPANLLQAQRDYFGAHTYKRVDKEGTFHTKWI....... 469
13 -11.500IDP01976 gene: gpsA; glycerol-3-phosphate dehydrogenase (NAD+) [Coxiella burnetii RSA 493] CBU_1518 [Coxiella burnetii RSA 493]  ali follow..  10  4...................................FKHPIAILGAGSWGTALALVLARKGQKVRLWSYESDHVDEMQAEGPFPETLKAYCDLKASLEGVTDILIVVPSFAFHEVITRMKPLIDAKTRIAGTKGLAKGSRLLHLGQVPMAVISGPSLATEVAA-------NLPTAVSLASNNSQFSKDLIERLHGQRFRVYKNDDMIGVELCGSVKNILAIATGISDGL--KLGSNARAALITRGLTEMGRLVSVFGGKQETLTGLAGLGVLTCTDNQSRNRRFGLALGEGVDKKEAQQAIGQAIEGLYNTDQVHALAQKHA............................................................................................................................................................................. 298
14 -11.300IDP01730 gene: gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [Francisella tularensis subsp. tularensis SCHU S4] FTT0871 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  12  2....................................QKNILVLGAGAWGTALALQLAYRGHNVRINSWKAEHNEQ-PSIEKFPSRLKAIQDWQANIIEFDSILVATPSSGFKNTILELKECILPQQNIIATKGFCHDSYALILPTTKFALLTGPSFAKELAN-------QLPTAVVV------ASKDINYARYVQELFSNENFRCYTTT-------DIIGAQ--VGGAVKNVLAITAGIAAGMEFGVNAHAALITRGLAEIKKLGLKLGLLTCSDNQSRNRRFGLYLGQGMTIQQALKEVNNVVEGYFTAKAVYNLAKKHN............................................................................................................................................................................. 297
15 -10.900IDP02668 gene: gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA1526 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  11  2.....................................TKITVVGAGSWGTALAMVLADNGHDVRIWGNRSELMDEINTKHTLPSTIVAYSSLEEALVDVNVVLIVVPTKAYREVLQDMKKYVAGPTTWIASKGIEPGTSKR-----ISEVIEEEIPEDLIKDVVVLSGPSHAEEVGQATTVTSAAKRMEAAEEVQDLFMNSYFRVYTNP-------DIVGVE--LGGALKNIIALAAGITDGLGLGDNAKAALMTRGLTEIARLGRKMGIVTCTSVHSRNWRAGNMLGKGHSLEEVLESMGMVVEGVRTTKAAHELAEKME............................................................................................................................................................................. 298
16 -10.500IDP92093 adenosylhomocysteinase, putative [Toxoplasma gondii ME49] TGME49_025050 [Toxoplasma gondii ME49]  ali follow..  23  218AINVNDCVTKSKFDNVYGCRHSLPDGIMRATDVMLGGKRVVICGFGDVGKGCAAAMKGAGARVVV------TEVDPICALQAAMEGYSVSTLESQLATADIFISATGNK--DIITARHMSQMKNNAIVGNIGHFDNEV.................................................................................................................................................................................................................................................................................................................................................................... 347
17 -10.200IDP05722 gene: tyrA; prephenate dehydrogenase [Bacillus anthracis str. Ames] BA_2954 [Bacillus anthracis str. Ames]  ali follow..  13  15.....................................KKVVLIGTGLIGGSLALAIKKDHDVTITGYDIFQEQVERAKELHVVDEIAV--DLQHACEEAHLIVFASPVEETKKLLHKLASFHLREDVIVTDVGSTMNEAEALFSKEISFIGGHPMAGSHKTGVESAKAH--NAFYILTPMHHVPNEHVEELKDWLKGTGSHF-----LVLNTEEHDYVTGIVSHFPHLIAAGL---VKQVEKHAGDNPLIHQLAAGGFKDITRIASSS-----------------------------KMWSDIV--KQNREHLMVLLKEWISEMEDLYDTVSSGDAGEIQNYFADAKEYRDSLPVRKR----GAIPAYHDLYVDVLDKVG------------ALAHVTSILAREEISITNLQILEAREGLLGVLRISFQREEDRMKAKLALGE................................................... 369
18 -10.100IDP91227 gene: tyrA; T-protein [Escherichia coli CFT073] NT04EC3201 [Escherichia coli CFT073]  ali follow..  12  100.....................................PVVIVGGGGQMGRLFEKMLTLSGYQVRILEQHDWD------------------RAADIVSDAGMVIVSVPIHVTEQVIGKLPPLPKDCILVDLASVKNGPLQAMLAAHDGPVLGLHP-----------MFGPDSGSL-VVVWCDGRKPEAYQWFLEQIQVWGAR---LHRISAVEHDQN-----MAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRAQDPQLYADIIMSSER-----NLALIKRYYKRFGEAIELLEQGD....................................................................................................................................................................................... 335
19 -9.700IDP00461 gene: tyrA; bifunctional chorismate mutase/prephenate dehydrogenase YPO3285 [Yersinia pestis CO92]  ali follow..  12  100.....................................PVVIIGGQGQMGRLFSRMLNLSGYQVRTLEQEDWS------------------QAESILADAGMVIVSVPIHITEEVINRL-PKLPADCILLLASVKNKPLQAMLAAHEGPVLGLHP-----------MFGPDVGSL-VVVYCDGRDPQAYQWLLEQLQVWGA---RLHRISAVEHDQN-----MAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRAQDPQLYADIIMSSED-----NLALIKRYYKRFGEALTLLEHHD....................................................................................................................................................................................... 335
20 -9.430IDP05101 gene: hbd; 3-hydroxybutyryl-CoA dehydrogenase [Clostridium difficile 630] CD1058 [Peptoclostridium difficile 630]  ali follow..  13  1.....................................MKLAVIGSGTMGSGIVQTFASCGHDVCLKSRTQGAIDKDEATKAEILSHVSSTTNYEDLKDMDLIIEASVENIKKDVFKLLDELCKEDTILATNTSS-----------SITEIASSTKRPDKVIGMHFFNPVPMMKLVEVISGQLTSKVTFDTVFELSKSIN....................................................................................................................................................................................................................................................................................................... 172
21 -9.270IDP00503 gene: fadB; multifunctional fatty acid oxidation complex subunit alpha YPO3766 [Yersinia pestis CO92]  ali follow..  9  277FVPLAGSNEARALVGIFLNDQYVKAQAKKLSKGVAAPKLAAVLGAGIMGGGIAYQSALKSVPVIMKDINENSLDLDGLKMASILATIRPTLDYAGIERAQVIVEAVVEKVKAAVLAEVEALIGEDTVLASNTST-----------PIDQLAKSLKRPENFCGMHFFNPVHRMPLVEIIRGAKTSDKTLAAVVAYATQMG-------------KTPIVVNDCPGFFVNRVLFPYLAGFGMLVRDGGDFDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAA----GFPERMNKDYRDAVDVMFDNQRFGQKNGQGFYRYTQDAKGVDKLLAEISQPLQEFSDEDIIARTMIPMINEVVRCLGIIASAAEGDMALVYGLGFPPFHG-----------FRYLDTLGSANYVEMAQRYAHLGALYHVPAGLRAKAEH........................................................... 709
22 -9.180IDP92082 glycerol-3-phosphate dehydrogenase, putative [Toxoplasma gondii ME49] TGME49_107570 [Toxoplasma gondii ME49]  ali follow..  10  21...................................GPLRVAVIGSGNWGSVIGKICAQNAEQVRMWVFEEMIEGQKLTDIKLPDNLVAVPDVVEACRGADLLVFVMPHQFVAKVCDQLAKA-SHARAISLLKGLYVEGGRPQLFSDT-AALSGANVANDVAREEF-----------AEATIGHSPDETDTALIWQQLFDKPYFKVN--TLPDVAGVQLCGAVKNVVALAAGFCDGTKSAIIRLGVEEMKQFGMIFFDNVIAETFFDSAGYADVITTVFGGRNARVRQKGSKTWDQIEAEMLQKLQGTLTAREVFEVISSHE............................................................................................................................................................................. 339
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.