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Query: IDP91187 gene: aph(2`)-Ib; aminoglycoside phosphotransferase [Enterococcus faecium] AF207840_1 [Enterococcus faecium], from CSGID

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVNLDAEIYEHLNKQIKINELRYLSSGDDSDTFLCNEQYVVKVPKRDSVRISQKREFELYRFLENCKLSYQIPAVVYQSDRFNIMKYIKGERITYEQYHKLSEKEKDALAYDEATFLKELHSIEIDCSVSLFSDALVNKKDKFLQDKKLLISILEKEQLLTDEMLEHIETIYENILNNAVLFKYTPCLVHNDFSANNMIFRNNRLFGVIDFGDFNVGDPDNDFLCLLDCSTDDFGKEFGRKVLKYYQHKAPEVAERKAELNDVYWSIDQIIYGYERKDREMLIKGVSELLQTQAEMFIFLast
1 -106.000IDP91187 gene: aph(2`)-Ib; aminoglycoside phosphotransferase [Enterococcus faecium] AF207840_1 [Enterococcus faecium]  ali  100  1MVNLDAEIYEHLNKQIKINELRYLSSGDDSDTFLCNEQYVVKVPKRDSVRISQKREFELYRFLENCKLSYQIPAVVYQSDRFNIMKYIKGERITYEQYHKLSEKEKDALAYDEATFLKELHSIEIDCSVSLFSDALVNKKDKFLQDKKLLISILEKEQLLTDEMLEHIETIYENILNNAVLFKYTPCLVHNDFSANNMIFRNNRLFGVIDFGDFNVGDPDNDFLCLLDCSTDDFGKEFGRKVLKYYQHKAPEVAERKAELNDVYWSIDQIIYGYERKDREMLIKGVSELLQTQAEMFIF 299
2 -96.800IDP95394 set236a-059 [Undefined organism]  ali follow..  55  1MMALTNELYRVLAAGFDIRDIRPLSCGDDSDAYLCDDVYVMKVPKRETVKKTQALEFQLYRFLEPFSFPCEIPKVIYQGEAFNMMTYIKGERLAYENYHKLSEKEKDRLACDEAEFLKALHSVEIPDSHPLYSELKLEVKDRFLQDQKKLLTILKAEKLLTPGRQAWVERIYRDLLDMDFLFAYRPCLTHNDYSADNMLYQKNRLTGVIDFGDAVIGDPDNDFLCLLDNSTDDFGKDFGRRVLRYYGHPHPELAERKAEINDAYWPVQQILLGHSRKEAQLFEEGIRDLEMV....... 293
3 -92.800IDP95452 set236a-054 [Undefined organism]  ali follow..  50  13.ITDIENAMERIGSPVR--ELRRLDAGDDSEVLLCNGLFVIKIPKRPSVRVTQQREFAVYSFLKQYDLPALIPEVIFQCSEFNVMSFIPGENFGFQEYALLSEKEKEALASDMAIFLRRLHGISVPLSEKPFCEIFEDKRKRYLEDQEQLLEVLENRKLLNAPLQKNIQTIYEHIGQNQELFNYAACLVHNDFSSSNMVFRHNRLYGVIDFGDVIVGDPDNDFLCLLDCSMDDFGKDFGRKVLRHYGHRNPQLAERKAEINDAYWPIQQVLLGVQREDRSLFCKGYRELLAIDPDAFIL 308
4 -85.600IDP91189 gene: aph(2``)-Id; APH(2``)-Id [Enterococcus faecium] AAW59417 [Enterococcus faecium]  ali follow..  30  6.FDQVEEAIEQLYPDFTINTIEISGEGNDCIAYEINGNFIFKFPKHSRASINLLNEVTVLKTIHN-ELSLPIPEVVFTGMPFAGFTKIKGVPLTPLLLKNLPKQSQDQAAKDLARFLSELHSINISGFKSNLVLDFREKINEDNKKIKK-----LLSRELKGHQMKKVDDFYRDILDNEIYFKYYPCLIHNDFSSDHILFDKNTICGIIDFGDAAISDPDNDFISLMEDD-EEYGMEFVSKILNHYKHKDIPTVLEKYMMKEKYWSFEKIIYGKEYGYMDWYEEGLNEIRSIKIK.... 301
5 -85.000IDP91796 gentamicin resistance protein [Enterococcus gallinarum] AAB49832 [Enterococcus gallinarum]  ali follow..  22  5.KLHYTTMIMTQFPDISIQSVESLGEGFRNYAILVNGDWVFRFPKSQQGADELNKEIQLLPLLVG-CVKVNIPQYVYIGKPFVGYRKVQGQILGEDGMAVFPDDAKDRLALQLAEFMNELSAFPVETAISAGVPVTNLKNKILLLSEAVEDQVF---PLLDESLRDYLTLRFQSYMTHPVYTRYTPRLIHGDLSPDHFLTNQTPLTGIIDFGDAAISDPDYDYVYLLEDC----GELFTRQVMAYRGEVDLDTHIRKVSLFVTFDQVSYLLEGLRARDQDWISEGLELLEEDKANN... 300
6 -83.500IDP95086 aminoglycoside phosphotransferase [Brachybacterium faecium] WP_015776248 [Brachybacterium faecium]  ali follow..  11  5.LDALLDLAARHGLDLDGGTLRTEEIGLDFRVAFAGGDWVLRLPRRPDVLERAAVEGRLLAMLAP-HLDVAVPDWRISTSELIAYPLLPGSPGADGEVSWHVDMASTVYARSLGSVVAQLHAVDAEAAAATGIEVRSPAQVRGAWRQDLARVGAEFE------IAPALRERWEAWLADDGCWPGHSVLTHGELYPAHTLVEDERITAVLDWTTAAVGDPAKDLMFHQVSAPSAIFEVALQAYAEG-GGRPWPGLARHCTEMFSAAPLGYGLYALATGEAAHREAAAAALNPPEER.... 298
7 -83.500IDP95392 putative aminoglycoside phosphotransferase [Brachybacterium faecium DSM 4810] YP_003155631 [Brachybacterium faecium DSM 4810]  ali follow..  11  5.LDALLDLAARHGLDLDGGTLRTEEIGLDFRVAFAGGDWVLRLPRRPDVLERAAVEGRLLAMLAP-HLDVAVPDWRISTSELIAYPLLPGSPGADGEVSWHVDMASTVYARSLGSVVAQLHAVDAEAAAATGIEVRSPAQVRGAWRQDLARVGAEFE------IAPALRERWEAWLADDGCWPGHSVLTHGELYPAHTLVEDERITAVLDWTTAAVGDPAKDLMFHQVSAPSAIFEVALQAYAEG-GGRPWPGLARHCTEMFSAAPLGYGLYALATGEAAHREAAAAALNPPEER.... 298
8 -81.000IDP95426 set236a-028 [Undefined organism]  ali follow..  20  31.AKEAAELIVREFPELQIETIKKLGGGLDNLAFEVNGEYIFRFPKRDEDNQKLLREGKVLELVKD-LSSVPVPEPTFKSTKFMGYRKIEGVSLLEG---RETFDGYEELAETLAKFLSQTHSLSLEEARRIGVPENSQSFSEWLADAPQFFEQAK------TRVPVELHAPIEKFLREESLGNWQPFFSHNDLGIEHIIVKDNSVTGIIDWADAEITDPAYDFGKLLRDLGEDLVKEILARYTVE--ANNKEEIFRRAVFYAKCSALEDLAYTAGDGKDKLYWDNSRAALKRLFRS... 314
9 -80.200IDP91794 gene: mphB; macrolide 2`-phosphotransferase II [Escherichia coli] BAA12910 [Escherichia coli]  ali follow..  13  5.IKQVIEIAKKHNLFLKEETIQFNESGLDFQAVFAGIDWVLRLPRREDVMPRTKVEKQALDLVNKYAISFQAPNWIIYTEELIAYKKLDGVPAGNYIWEIDINNVPELFHKSLGRVLAELHSIPSNKAAALDLVVHTPEEARMSMKQRMDAVRAKFG------VGENLWNRWQAWLNDDDMWPKKTGLIHGDVHAGHTMIDDANVTGLIDWTEAKVTDVSHDFIFNYRAFGEEGLEALILAYKEI-GGYYWPKMKEHIIELNAAYPVSIAEFALVSGIEEYEQMAKEALEVQGS..... 302
10 -80.000IDP95085 aminoglycoside phosphotransferase [Brachybacterium paraconglomeratum] WP_010550189 [Brachybacterium paraconglomeratum]  ali follow..  14  33.LEQLLALAADHGLDLLGDSLRTEEIGLDFRVAFAWQDWVLRIPRRAEVLARAAVEGRLLAHLAP-HLDIAIPDWRISTERLIAYPLLPGTPGADGTVEWHVDMASTEYARALGTFLAQLHTVDPEEAAATGIPSRTPSEVRGVWREDLTRVAEAFP------IAPALRERWEAWLAEDSYWPDRSVLTHGEVYPGHTLVEGERLSAVLDWTTASVGDPARDLMFHRSSAPPEAFAATLAAYVAG-GGTLHPRLGEHAEEMFSASPLAYGLYALETGEEEHRAAAAAALDPPDAD.... 326
11 -79.100IDP95359 set215a-002 [Paenibacillus]  ali follow..  11  14.IQEMLEIAGKHGVNLIPEGIEMNESGMDFLVGFAGARWILRKPRRPDVLDRADNEARVLKLIQSH-LSVDVPDWRIYTPELIAYPLLSGQPMEGYAWNMDHENPGDGFIRSLAEALVALHGVDHDAARAAGLRVKSPQEVRDETARNMEDIKSRLG------VSDALWERWQKWLEEDSYWPTHSALIHGDLHPPHILIDRVQVTGLLDWTESEVASPAKDFVLYYAIYGEHNLRVLLDRYEQA-GGKVWPRMFDHIVEQHAAYPVLIAQFALLTGQEEYMTMARNALGLT....... 307
12 -78.900IDP95360 set225-001 [Brevibacillus brevis]  ali follow..  14  6.VEHMLALAKNNGILVDPTTVKVNESGLDFLAIFAGIPWVLRQPRRDDVVETARYEKRVLDLVAK-HLRVEVPDWQVHTSEFIAYPILGGTPMATINMYLNPESLPELCIQTWAEALVELHGIHHDLARDAGIRVKQP------SYARASLREKMNEIKRVFGVSGALWDRWQKWLADETFWPAHSALVHGDLHPGHILVANGKVTGLLDWTEAEVSDPAIDFTVVYLLFGDTGLADFIQRYEKA-GGRVWSRMHEHIVEMTAAYPVTLATFALKSGLEEFKIMARQALGVDENGK... 304
13 -78.800IDP95429 set236a-031 [Undefined organism]  ali follow..  15  7.MRDVAALVREALAGRDVHTIVEIEGGSDHRTFDVNGALVARLRRRPDTASAIMREVRLLEVVSRSPVPVPDVAGANPDRGLIVVTRLPGVPLL-----DSPPRHPMALIDPLARFLRAVHGLPIAELEDLVERDEYGFEDYLEDAAEDLRQVAAHLP------SDQQRAVEAFLGAPPPAASDNRTFCHNDLGAEHMLASDSVLTGVIDWSDAAIADPARDVGRILR----DLGPAVARAIVRQLECAEPHHLLARARFYARCALLEDVSYGLRTAHHRYAERALDHFRGVFED.... 290
14 -78.700IDP00045 aminoglycoside phosphotransferase family protein BA_3111 [Bacillus anthracis str. Ames]  ali follow..  16  1MNQIVKRLIREQFPEWAHLEVKPVFSGHDNRTFQLGDKMSVRLPSDAAYTPQVEKENKWLPILSKLSLPISTPIAKGNPSEAYPWPWSINKWIEGETVTKQNVRDLSEFAAHLGSFLVELQSIDASKGPIAGAHNFYRGGLISVYDEEARDAIENNKDVFDETVLKHLWD-----LALQSTWRRKPVWIHGDVAPGNLLVKDGKLCAVIDFGILGVGDPACDAAMSWTFFDKSSRKIFKEVL------QIDEETWNRARGWALWKALITYDANKI-SNKIVAEESYRVIQVIVNDYG.. 291
15 -77.600IDP95393 MphBM [Staphylococcus aureus] BAA34540 [Staphylococcus aureus]  ali follow..  13  5..NEIIKCAEKYQLHIQPQTISLNESGLDFQVAFGGVEWVLRLPRRPDVYKRTKPEKQTVDFLQK-NVSFEVPKWKVHERDLIAYPKLTGKPIQNYVWEIEHKPLPENFINTLAETLVDLHNIPEENINVQHINIKTIQEIKNDFQRRMNKVKETYG------VSDELWNRWKQWLENDELWPRHATMIHGDLHPGHIMVDQANVTGLIDWTEATHSDPSMDFMGHHRVFDDEGLEQLITAY-GKAGGEIWPRMKEHIIELNAVFPMFIAEFAMESGESAYETMALKELG......... 296
16 -76.500IDP00035 macrolide 2-phosphotransferase, putative BA_1589 [Bacillus anthracis str. Ames]  ali follow..  12  3.TLKVKQLANKKGLNILEDSIEINESGVDFQVAHVGDKWILRIPRRPESMRHALREKEALEIMKK-HAAFQVPNWSIFSEELIAYKQLSGFPAQKYVWNFNEKNVPTEYYISLGKVLANVHSLSQQKFNNIGVEILTANELRTSMKQRMNRVKEQYH------INQNLWDRWQAWLAEDSFWPSHVGVKHGDIHPGHILIDKNNVTGLIDWTEVGIGDVSIDFTSHYLLFGKDGLTKLIHSYDNA-GGKTWSRMDEHIIELLTTSSITVAEYAQVSGLKDMHEAAIHMLATEC...... 298
17 -75.900IDP91793 gene: mphA; macrolide 2`-phosphotransferase I [Escherichia coli] BAA03776 [Escherichia coli]  ali follow..  13  9.TSQLYALAARHGLKLH-GPLTVNELGLDYRIVIAGRRWVLRIPRRAEVSAKVEPEARVLAMLKN-RLPFAVPDWRVANAELVAYPMLEDSTAGSSTPDWVVPQDSEVFAESFATALAALHAVPISAAVDAGMLIRTPTQARQKVADDVDRVRREFV------VNDKRLHRWQRWLDDDSSWPDFSVVVHGDLYVGHVLIDNERVSGMIDWSEARVDDPAIDMAAHLMVFGEEGLAKLLLTYEAA-GGRVWPRLAHHIAERLAFGAVTYALFALDSGNEEYLAAAKAQLAAA....... 300
18 -72.900IDP91190 6`-aminoglycoside N-acetyltransferase [Enterococcus faecalis V583] EF_A0061 [Enterococcus faecalis V583]  ali follow..  27  185NVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSTNKKKGYAKEKAIYNFLNTLETNVKIPNIEYSELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDL-------TDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYK.... 478
19 -67.900IDP95447 set236a-049 [Undefined organism]  ali follow..  32  4.LYEVEQILR--NKQVFVCSLAFLGEGEHSEAFLVNRDIVVKLPKHRQASECLKTEMQVVKGLGT-KLNVEIPNVLFQGAFYFGSRKLPGHSLNKKQFCALPKPILDKNAEIVANFLYRLHS----------------------------------------------------EKNVLPIQREGDVLVHGDFSLNHLLFDNQMVCSVLDFGDSHVGDFQEDFLYLLDEEEEEFGANFGREVLENYKSISSCSLQGE.......................................... 214
20 -66.900IDP95397 set236a-062 [Undefined organism]  ali follow..  31  84.NVKAIKYIIEHSFDIKITSIKLIGNGNDSFAYEVNDNMIFKFPRHEKANENLLKEIEILQYLEN-KTTFNIPKVLYVNNDIACFTKINGVSLSKEIYERLTDEEKDKLAQDLARFLKELHSSNYNKYQVDTIENYKKDYARLVELIF---------DKLDDNEKMVINNIYNSILSNDDMLTINKSLVHNDFSCGNILFDTNRISGIIDFGDSCVSDTDNDFY........................................................................... 305
21 -66.300IDP95401 set236a-066 [Undefined organism]  ali follow..  28  185NVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSTNKKKGYAKEKAIYNFLNTLETNVKIPNIEYSELSILGYKEIKGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTDIE-------KDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVY........................... 455
22 -54.500IDP95417 set236a-019 [Undefined organism]  ali follow..  20  1................................................................................................................MADFMRQVHAIPLEAVSACGIPTFQTLTHFGEVMERARDTL---RPHLTDAVWNHHEALLARATANPRFDHYTPVLLHGDLSPDHFLADTGKLTGVIDFGDVCIGDPAWDFVYILE----DYGADVLTAFLAHYDSDNAAFLAEKVRTYQHLNNVAYGVSALAEGNDDDFAEAMAILTEQAR..... 177
23 -53.900IDP95123 gene: str; putative APH(3``) streptomycin phosphotransferase [Klebsiella pneumoniae subsp. pneumoniae MGH 78578] YP_001338789 [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]  ali follow..  10  1.MKEPPLNRTNIFFGESHSDWLPVRGGESGDFVFRDGHAFAKIAP-ASRRGELAGERDRLIWLKGRGVACPEVINWQEEGACLVITAIPGVPA-----ADLSGADLLKAWPSMGQQLGAVHSLSVDQCPFERRLSRMFGRAVDVVSRNAVNPDFLPDEDKSTPQLDLLARVERELPVRLDQERTDMVVCHGDPCMPNFMVDPKQCTGLIDLGRLGTADRYADLALMIANAEENWAERAFAVLFNVLGIEAPDR--ERLAFYLRLDPLTW.............................. 271
24 -53.200IDP91191 gene: aphA1; Aminoglycoside phosphotransferase [Acinetobacter baumannii] CAJ77079 [Acinetobacter baumannii]  ali follow..  17  1MSHIQRELNSNLDADLYGYRWARDNVGQSGAIYRLYGKLFLKHGK-GSVANDVTDEMVRLNWLTAF---MPLPTIKHFDDAWLLTTAIPGKTAFQVLEE--YPDSGENIVDALAVFLRRLHSIPVCNC-----PFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCL-GEFSPSLQKRLFQKYGIDNPD--MNKLQFHLMLDEF................................ 270
25 -52.100IDP91186 unnamed protein product [Streptomyces griseus] CAA37605 [Streptomyces griseus]  ali follow..  9  20...................DWLAVTAGESGASVFRDATRYAKCVP-AADAAGLEAERDRIAWLSGQGVPGPRVLDWYAAGACLVTRAVPGVPAD-----RVGADDLRTAWGAVADAVRRLHEVPVASCPFRRGLDSVVDAARDVVARGAVHPEFLPVEQRLVPPAELLARLTGELARRRDQEAADTVVCHGDLCLPNIVLHPEEVSGFIDLGRLGAADRHADLALLLANADEERARFADAAFAERYGIAPDP---ERLRFYLHLDPLTW.............................. 271
26 -51.800IDP91797 neomycin phosphotransferase [Escherichia coli] CAA23892 [Escherichia coli]  ali follow..  13  1MIELHAGSPAAWVERLFGYDWAQQTIGCSDAVFRLGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTGRDWLLLGEVPGQDLLS------SHLAPAEKVSIMADAMRRLHTLDPATC-----PFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDS--QRIAFYRLLDEF................................ 263
27 -51.100IDP91188 unnamed protein product [Escherichia coli] CAA24743 [Escherichia coli]  ali follow..  13  8.ATSVEKFLIEKFDSVS--DLMQLSEGEESRAFSFGRGYVLRVNSCA---DGFYKDRYVYRHFASAALPIPEVLDIGESLTYCISRRAQGVTL-----QDLPETELPAVLQPVAEAMDAIAAADLSQTSGFGPFGPQGIGQYTTWRDFICAIADPHQTVMDDTVSASVAQALDELMLWAEDCPEVRHLVHADFGSNNVLTDNGRITAVIDWSEAMFGDSQYEVANIFFWRPWLACMEQQTRYFERRHPELAGS--PRLRAYMLRIGLDQLYQSLVDGNFDDAAWAQGRCDAIVRSG... 300
28 -50.000IDP91870 unnamed protein product [Acinetobacter baumannii] CAA30578 [Acinetobacter baumannii]  ali follow..  15  3LPNIIQQFIGNS-------VLEPNKIGQSPDVYSFNETFFLKRTLYTETTYSVSREAKMLSWLSE---KLKVPELIMTQFEFMITKAINAKPISALF------LTDQELLAIYKEALNLLNSIAIIDCPISNIDHRLKESKFFIDNQLLDDIDQDDFDTELWGDHKTYLSLWNELTETRV--EERLVFSHGDITDSNIFIDKFNEIYFLDLGRAGLADEFVDISFVERCLREDASEETAKIFLKHLKNDRPD----KRNYFLKLDELN............................... 259
29 -49.300IDP91192 gene: neoU; aminoglycoside 3`-phosphotransferase [Streptomyces fradiae] BAD95814 [Streptomyces fradiae]  ali follow..  14  1...MDDSTLRRKYPHH---EWHAVNEGDSGAFVYQQPELYAKIAPRANSAFDLSGEADRLEWLHRHGIPVPRVVERGATAAWLVTEAVPGVAAAEE----WPEHQRFAVVEAMAELARALHELPVEDC-----PFDRRLDAAVAEARRNVAEGLVDLDDLQEERAGWTGDQLLAELDRTRPEKEDLVVCHGDLCPNNVLLDPGRVTGVIDVGRLGVADRHADIALAARELEIDFGPAYAERFLERYGAHRVDK--EKLAFYQLLDEF................................ 267
30 -47.700IDP95456 set236a-058 [Undefined organism]  ali follow..  19  2..................................................................KIAGGMTMSHFKGKQFQQDVIIVAVGY----YLRYNLSYREVQEILYDRGINVSHTTIYRWVQEYGKLLYQIWKKKNKILLLSEAVEDQVFPLLDESLRDYLTLRFQSYMTHPVYTRYTPRLIHGDLSPDHFLTNQTPLTGIIDFGDAAISDPDYDYVYLLE----DCGELFTRQVMAYRGEVDLDTHIRKVSLFVTFDQVSYLLEGLRARDQDWISEGLELLEEDKANN... 227
31 -46.500IDP95443 set236a-045 [Undefined organism]  ali follow..  44  2......................................................................................................................PLSEKPFCEIFE-------DKRKRYLEDQEQLLEVLENRKLLNAPLQKNIQTIYEHIGQNQELFNYAACLVHNDFSSSNMVFRHNRLYGVIDFGDVIVGDPDNDFLCLLDCSMDELWERFRAKGFKALWPSESTISRKKSRNQ...................................... 137
32 -45.700IDP91795 unnamed protein product [Enterococcus faecalis] CAA24789 [Enterococcus faecalis]  ali follow..  15  4.....MRISPELKKLIEKYRCVKDTEGMSPAKVYKNENLYLKMTDSRGTTYDVEREKDMMLWLEGK---LPVPKVLHFGWSNLLMSEADGVLCSEEY---EDEQSPEKIIELYAECIRLFHSIDISDCPTNSLDSRLAELDYLLNNDLADVDCENWEEDTPFKDPRELYDFLKTEKPEE-----ELVFSHGDLGDSNIFVKDGKVSGFIDLGRSGRADKWYDIAFCVRSIREDIGEQYVELFFDLLGIKPDW---EKIKYYILLDEL................................ 263
33 -42.500IDP00063 aminoglycoside phosphotransferase family protein BA_4952 [Bacillus anthracis str. Ames]  ali follow..  16  2..........EWLEQLLGKEWSVPAGGVTGDAYIAQQKLFLKR-----------NTSPFLAVLSAEGI---VPKLLWTGDVISAQKWLPGQKLEPEDMK----------LERVAKLLKKIHSSKALVQMIQRLGKQPLHAQELLQQLQLVLRGDIRDEETIQQGLQYLMDSLKDI-------YNEFVVCHCDVNHNNWLLSDEDELFLIDWDGAVIADPALDLGMLLY---WYIPRQEWSEWLGYYDIEMDESLLKRMRWYVIAQTILSIQWHTTKKQQAEAEYWHQYLQQLLAS.... 262
34 -41.500IDP90857 hypothetical protein YPO1614 [Yersinia pestis CO92] YPO1614 [Yersinia pestis CO92]  ali follow..  11  2..............KTADCHISPVS-GLTGESWRIGIDWLAREQSPHKSQLGVNRERKFLQHIAGNGLS---PAVIAANQRWLVVNWLEGDVVTNEQF------IPLVNHGQLARLLARLHHLPASGYRLDLRAQIARYGALIDPTRRS----------------PGGVRLQHDFLRRPLPAITKIAPLHMDIHPGNLLTTPVGLK-LIDWEYAADGDIALEIAALFNHWSMLQQQAFLQDYCNNEHGYHDARLSRQIQQWLPWVDYLMLMWFEQTADPIFLAWAAPLRQRFNLSF... 268
35 -40.800IDP91792 gene: aph; spectinomycin phosphotransferase [Legionella pneumophila 130b] AAB58447 [Legionella pneumophila 130b]  ali follow..  9  9..QQLIELLKVHY-GIDIHTAQFIQGGADAFAYQASKSYFIKLKYGY----HDEINLSIIRLLHDSGIKIIFPIHTLEAKKIIAYPFIHAPNGFTQNLTG-------KQWKQLGKVLRQIHETSVPISIQQQLRKEIYSPKEFDNSDDKLTAAFKSFFNQNSAAIHRLVDTSEKLSKKIQPDLDKYVLCHSDIHAGNVLVGNEESIYIIDWDEPMLAPKERDLMFIGGVGNVWNKPHEIQYFYEGYGEINVDK--TILSYYRHERIVEDIAVYGQNQNNQSRLESFKYFKEMFDPNNVV 323
36 -27.200IDP95128 streptomycin resistance protein B [Klebsiella pneumoniae subsp. pneumoniae MGH 78578] YP_001338790 [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]  ali follow..  9  3....LMFMPPVFPAHWHVSQPVLIADTFSSLVWKVGTPAIVKGLKPI---EDIADELRGADYLVWRN---GAVRLLGRENNLMLLEYAGERM----LSHIVAEHGDYQATEIAAELMAKLYAASEEPLPSA-----------LLPIRDRFAALFQRARDDQNAGCQTDYVHAAIIADQMMSNASELRGLHGDLHHENIMFSSRGWL-VID--VGLVGEVGFGAANMFYDPADRDDLCLDPRRIAQMADAFSRAL-RRLLDQAYAYGCLSAAWNADGEEEQRDLAIAAAIKQVRQTS... 280
37 -25.000IDP06008 choline/ethanolamine kinase, putative [Toxoplasma gondii ME49] EEB01489 [Toxoplasma gondii ME49]  ali follow..  11  213RSRVTASPFSHRGEGTKKEDEEVSERNAQDQQKTCCTRVLIRVHPADTELFDPRVEQRLFKQLGEVGIA---PCCLGEFEGGRVEAWLEGQPLKTADLHT------EEIQTKLASQLPHRLKLQRTTTETETEEKNGVSA-ETYRKKAEQLREAILKRVESELSPESLQTVYGSEGRWRLLSAASLVLSHNDLQENNLMVCVEWQNERVEARRKTKRQAKEGGR........................................................................... 500
38 -24.300IDP91798 gene: aph(6)-Ia; aminoglycoside-6-phosphotransferase Ia [Streptomyces griseus] AAX82592 [Streptomyces griseus]  ali follow..  10  29.IAGLPALVARCVDRWELKRDGGVRSGEASLVVPVGTRAALKLQMPR---EETTAALIGLRAWGGDGM-VRLLDHDEESSTMLLERLDGSRTLA-------SVEDDDEAMGVLAGLLNRLHSVPAPPGLRGLGEIAGAMVEEVPSAVDSLADPEDRSRLRGWASAVAELV------------EPGDRVLHWDLHYENVLAAEREPWLAID--EPLVGDPGFDLWPALDIEATGDARRVVRRRFDLLTEALELD--GRAAGWTLARLLQNTLWDIEDGLTAIAPSQIAVAEALAK..... 306
39 -21.100IDP91564 gene: ECs0848; hypothetical protein [Escherichia coli O157:H7 str. Sakai] BAB34271 [Escherichia coli O157:H7 str. Sakai]  ali follow..  12  137.....................NVIGKGGNAVVYE-DATKVLKMFTTSQSNEEVTSEVRCFNQYYGAGS-AEKIYGNNGDIIGIRMDKINGESLLN-------SSLPAQAEHAIYDMFDRLEQKG---------------------------------------------------------------ILFVDTTETNVLYDAKNEFNPIDISSYNVSDRSWS............................................................................. 270
40 -20.900IDP91568 gene: ECs1814; hypothetical protein [Escherichia coli O157:H7 str. Sakai] BAB35237 [Escherichia coli O157:H7 str. Sakai]  ali follow..  12  147.....................NVIGKGGNAVVYE-DTTKVLKMFTISQSHEEVTSEVRCFNQYYGSGS-AEKIYNDNGNVIGIRMNKINGESLLD-------PSLPAQAEQAIYDMFDRLEKKG---------------------------------------------------------------ILFVDTTETNVLYDMRNEFNPIDISSYNVSDISWS............................................................................. 280
41 -13.100IDP06384 gene: ORF36; ORF36 [Human herpesvirus 8] YP_001129389 [Human herpesvirus 8]  ali follow..  12  88.....................KRLGRGAFGIIVPISEDLCVKQFDS---RREFFYEAIANDLMQATRERLLGFVQPCIPCRSIVYPRMKCN-LLQLDWSQVNLSVMAAEFTGLMAAVSFLNR-----------------------------------------------------------------MVHCDVSPDNILATGD--LVLTDFGSVALHSGSKWTNLVVT....................................................................... 243
42 -12.100IDP06302 serine/threonine protein kinase [Streptococcus pneumoniae TIGR4] NP_346168 [Streptococcus pneumoniae TIGR4]  ali follow..  11  1MIQI--KIFAGRYR------VKQIGRGGMADVYILDGEEVANYQTDPIAVARFQREARAMADLDHPHIVRITDIGEEDGQQYLAMEYVAGLDLKRKEHYPLSNEEAVRIMGQILLAMRLAHT-----------------------------------------------------------------IVHRDLKPQNILLTPDGTAKVTDFG----------IAVAFAETSLTQTNSMLGSV--HYEQARGSKATVQSDIYAMGIIFYEMLTGIPYDGDSAVTIALQHFQKPLPS.... 231
43 -10.400IDP91699 gene: EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform a [Homo sapiens] NP_002750 [Homo sapiens]  ali follow..  12  266................DFKEIELIGSGGFGQVFKAGKTYVIK--RVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDFIQMEFCDKGTLEKRRGEKLDKVLALELFEQITKGVDYIHS---------------------------------------------------------------KKLIHRDLKPSNIFLVDTKQVKIGDFGLVTKGTLRYDLYAL......................................................................... 474
44 -9.970IDP90141 ser/thr protein kinase-like protein [Monkeypox virus] MPXV_ZAI1979_005_186 [Monkeypox virus]  ali follow..  16  19.....................NTLYSGNSILYKVRKNNYVMKIDHKSH--KPLLSEIRFYISVLDPLT-LAIPDLYGIGETFFVIKNL------GRVFAPKDSESVFEACVTMINTLEFIHSRG---------------------------------------------------------------FTHGKIEPMNILIRNKRIS-LIDYSRTN.................................................................................... 161
45 -9.920IDP90197 gene: CPXV206 CDS; CPXV206 protein AAM13645.1 [Cowpox virus (Brighton Red)]  ali follow..  16  19.....................NTLYSGNSILYKVRKNNYVMKIDHKSH--KPLLSEIRFYISVLDPLA-LAIPDLYGIGETFFVLKNL------GRVFTPKDTESVFDACVTMINTLEFIHSRG---------------------------------------------------------------FTHGKIEPRNILIRNKRLS-LIDYSKTN.................................................................................... 161
46 -9.800CPX_91699_91671 Complex of E2AK2_HUMAN with VK03_VACCC [Undefined organism]  ali follow..  12  266................DFKEIELIGSGGFGQVFKAGKTYVIK--RVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDFIQMEFCDKGTLEKRRGEKLDKVLALELFEQITKGVDYIHS---------------------------------------------------------------KKLIHRDLKPSNIFLVDTKQVKIGDFGLVTKGTLRYDLYAL......................................................................... 474
47 -9.560IDP90949 gene: MAPK14; mitogen-activated protein kinase 14 isoform 2 ZZZ_0019 [Homo sapiens]  ali follow..  13  27....................LSPVGSGAYGSVCAAGLRVAVK--QSIIHAKRTYRELRLLKHMKHENV-TPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD---------------------------------------------------------------IIHRDLKPSNLAVNEDCELKILDFGLARTDDEMTGYVATRWYRAPEI--------WMHYNQTVD--------IWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV...... 239
48 -9.290IDP90192 gene: CPXV196 CDS; CPXV196 protein AAM13635.1 [Cowpox virus (Brighton Red)]  ali follow..  12  20.....................PLIGKGGFGSIYTNDNNYVVKIEPKANLKPSVIEEWKKTRHIKHVGV----ITCKAFGLRFLVINRL-GADLDAANNNRLPKRSVMLVGIEILNTIQFMHEQG---------------------------------------------------------------YSHGDIKASNIVLDQMDKNKLVDYGLVS.................................................................................... 172
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.