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Query: IDP95479 S-adenosylhomocysteinase Q5CPH1 [Cryptosporidium parvum], from CSGID

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst YKMESRIKDISLAEFGLQDMEIAKTDMMGLVELQRKYRDSKPLKGARITGSLHLTIETSVLVETLYELGAEIRWCSCNIYSTQDHAAAALVKKNIATVFAWKNETIEDYWVCLNDAMTWRNPNDKDKICGPNLIVDDGGDATLILHEGVKAEIEYEKYNKIPEYLETELDENGKQLSMDLKCMYKVLKMELLKNPFRWRGMLKDLYGVSEETTTGVLRLKIMESEGKLLLPAINVNDSVTKSKFDNTYGCRQSLLHGLFNGCIQMLAGKKIVVLGYGEVGKGCAQGLSGVGARVIVTEIDPICALQASMEGYQVSVLEDVVSEADIFITATGNKDVITVEHMRKMKENAYIANIGHFDDEIDVYGLENYPGIKVIEVKQNVHKFTFPDTQKSVILLCKGRLVNLGCATGHPPLVMSMSFTNQVLAQMDLWKSRELVDRSKNTRFFVKKLSKELDEYVARLHLDVLGIKLTKLTETQAKYINVSINGPYKSEDYRYLast
1 -132.000IDP95479 S-adenosylhomocysteinase Q5CPH1 [Cryptosporidium parvum]  ali  100  1YKMESRIKDISLAEFGLQDMEIAKTDMMGLVELQRKYRDSKPLKGARITGSLHLTIETSVLVETLYELGAEIRWCSCNIYSTQDHAAAALVKKNIATVFAWKNETIEDYWVCLNDAMTWRNPNDKDKICGPNLIVDDGGDATLILHEGVKAEIEYEKYNKIPEYLETELDENGKQLSMDLKCMYKVLKMELLKNPFRWRGMLKDLYGVSEETTTGVLRLKIMESEGKLLLPAINVNDSVTKSKFDNTYGCRQSLLHGLFNGCIQMLAGKKIVVLGYGEVGKGCAQGLSGVGARVIVTEIDPICALQASMEGYQVSVLEDVVSEADIFITATGNKDVITVEHMRKMKENAYIANIGHFDDEIDVYGLENYPGIKVIEVKQNVHKFTFPDTQKSVILLCKGRLVNLGCATGHPPLVMSMSFTNQVLAQMDLWKSRELVDRSKNTRFFVKKLSKELDEYVARLHLDVLGIKLTKLTETQAKYINVSINGPYKSEDYRY 495
2 -108.000IDP92093 adenosylhomocysteinase, putative [Toxoplasma gondii ME49] TGME49_025050 [Toxoplasma gondii ME49]  ali follow..  56  2.AEQSKVKDLTLSAFGRKEIELAEGEMPGLMALRKEFGPRQPLKGAKISGSLHMTVQTAVLIETLKALGAELRWCSCNIFSTQDHAAAAIVKNNSAAVFAWKGETLEEYWWCTVMALTWGEGA------GPDLLVDDGGDATLLIHEGVKAEKE--------FARSGALPDPAATDNLEMKVVYKILAEGLQKDPQKWSRMAANLKGVSEETTTGVHRLLQMAKKKELLFPAINVNDCVTKSKFDNVYGCRHSLPDGIMRATDVMLGGKRVVICGFGDVGKGCAAAMKGAGARVVVTEVDPICALQAAMEGYSVSTLESQLATADIFISATGNKDIITARHMSQMKNNAIVGNIGHFDNEVDMAGLLAWPGIQKVNIKPQVDRFIFPEDNHGVIVLAEGRLLNLGCATGHPSFVMSCSFTNQTLAQLDLWDN----VATKRYQNDVYLLPKELDEKVARLHLPALGCELTTMSQEQAAYVGIKPEGPYKSASYRY 477
3 -26.600IDP02524 gene: ilvC-2; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1852 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  15  8...................................................................................................................................................................................................................................................................DANVGLLQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGFEVMSVSEAVRTAQVVQMLLPDEHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSYVDVAMVAPK------SPGHLVRRVFQEGNGVPALVAVHQDATGTALHVALAYAKGVGCTRAGVIETTFQ---------------EETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYF. 224
4 -20.000IDP02330 gene: ilvC-1; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1419 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  21  9...................................................................................................................................................................................................................................................................DVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTVAEAAKQADVVMILLPDEEVYEEEIAPNLQAGNSLVFAHGFNVHFD..................................................................................................................................... 114
5 -16.200IDP90757 gene: ilvC; ketol-acid reductoisomerase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj0632 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  21  15........................................................................................................................................................................................................................................................................LIKSKKVAIIGFGSQGHAHAMNLRDNGVNVTIGLREGSVSAVAKNAGFEVVSVSEASKIADVIMILAPDEDIFNVEIKPNLSEGKAIAFAHGFNIHYG..................................................................................................................................... 116
6 -12.900IDP02277 glycerate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA1434 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  16  68...............................................................................................................................................................................................................IVANYGAGYDNI-DYTYAGEKGIAVTNTPKVSTEATAELTFALLLAAARRIPEGLGREVHGKTIGIIGLGEIGKAVAKRAKAFGMNILYTGPNRKPEAESEL-EATYVTLEELLQTADFITINPKLHHMIDEEQFKMMKKTAYIVNASRGPIMHEAALAHALKTNEIEGAALDVFEFEPKITEELKGL-------NVVLAPHVGNATFETRDAMAEMAVRNILA................................................................ 304
7 -12.800IDP91791 gene: vanH; vancomycin resistance protein [Enterococcus faecium] AAA24789 [Enterococcus faecium]  ali follow..  19  74...............................................................................................................................................................................................................YISTRSIGCNHI-DTTAAKRMGITVDNVAYSP-DSVADYTMMLILMAVRNVKSIRGKVLSDMTVGVVGTGQIGKAVIERLRGFGCKVLAYSR-------SRSIEVNYVPFDELLQNSDIVTLNTDTHYIISHEQIQRMKQGAFLINTGRVDTYELVKALEN............................................................................................................................... 246
8 -12.200IDP90820 gene: pdxB; erythronate-4-phosphate dehydrogenase [Salmonella typhimurium LT2] STM2370 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  11  35......................................................................................................................................................................................LNHADALMVRSVTKVNESLLSGTINFVGTATAGTDHV-DEAWLKQAGIGFSAAPGCNAIAVVEYVF----SALLMLAERDGFSLRDRTIGIVGVGNVGSRLQTRLEALGIRTLLCD------RAARGDEGDFRTLDELVQEADVLTFHTKTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEPDLNVA----LLEAVDIGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQRVALETLLPAPEFGRITLHGPLDQPTLKRLAHLVYDVRRDDAPLRKVAGIPGEFDKLRKNY 343
9 -12.000IDP04474 gene: pdxB; putative D-isomer specific 2-hydroxyacid dehydrogenase [Yersinia pestis CO92] YPO2763 [Yersinia pestis CO92]  ali follow..  11  35......................................................................................................................................................................................LVDADALMVRSVTKVNEALLHG-IGFVGTATAGTDHV-DDTWLRQQGIGFSAAPGCNAIAVVEYVF----SALMMMAERDGFQLRDKTVGIIGVGNVGSRLNARLQALGVRTLLCD------RADRGDNEAFWPLEKLVREADVLTFHTQSLHMADDELLAALPDGRILINACRGA------------------------------------VVDNAALLRALEKGKKLSVVLDVDLSLPLLARVDIGTPHIAGYTLEGKARGTTQVFEAFSQHL...................................... 278
10 -12.000IDP90773 erythronate-4-phosphate dehydrogenase [Vibrio cholerae O1 biovar eltor str. N16961] VC2108 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  15  41......................................................................................................................................................................................LIDVDALMIRSVTKVNDALLAK-LKFVGTATAGMDHV-DQALLRERGIFFTAAPGCNKVGVAEYVF----SVLMVLAQQQGFSVFDKTVGIIGAGQVGSYLAKCLSGIGMKVLLND------KQAQGDEREFTELETLLKQADVITLHTPTHHLIDAAILEQLRSDQILINAARGPV-VDNAALKAR.............................................................................................................................. 227
11 -12.000IDP00460 gene: serA; D-3-phosphoglycerate dehydrogenase YPO0914 [Yersinia pestis CO92]  ali follow..  13  45.........................................................................................................................................................................ESLKASIRDAHFIGIRSRTHLSEDVFAAAEKLV-----AVGCFCIGTNQV-DLKAATKRGVPVFNAPFSNTRSVAEMVLGELLLMFRGIPSAGSFEARGKKLGIIGYGHIGTQLGILAESIGMKVFFYDI---ENKLSLGNAQQVRQLSDLLNMSDVVSLNHTTKNMIGAEQLAQMKPGALLINASRGTV-VDIPALCDALSSNHLS----------------------GAAIDVFPEEPATN---KDPFNSPLCEFDNVLLTPHIGGSTQEAQENIGKLAKYSDNGSTLSAVNFPEVSLPAHGDNTRRLLHIHEN.......... 348
12 -11.800IDP90565 ketol-acid reductoisomerase [Vibrio cholerae O1 biovar eltor str. N16961] VC0162 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  21  1.......................................................................................................................................................................................................................................MANYFNTLNLREQLDQLGRCRFMAREEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVSYIDEQRQSFKNAKNNGFNVGSYEQLIPTADLVINLTPDKTSVVNAVMPLMKQGAALGYSHGFN......................................................................................................................................... 135
13 -11.700IDP00951 gene: ycdW; putative oxidoreductase STM1135 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  60................................................................................................................................................................................................................VFVLGAGVDAILSKLNAHP-SIPLFRLEDTGMGLQMQEYA-QALKNQALWKPLPEYTREEFSVGIMGAGVLGAKVAESLQAWGFPLRCWSRSR-KSWPGVESYVGREELRAFLNQTRVLINTAQTVGIINSELLDQLPDGAYVLNLARGV------------------------------------HVQEADLLAALDSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTP-------HIAAVTRPAEAIDYISRTIGEPVTGQVDRARGY................ 312
14 -11.200IDP06064 3-hydroxyacid dehydrogenase [Helicobacter pylori J99] NP_223303 [Helicobacter pylori J99]  ali follow..  16  2.............................................................................................................................................................................................................................................................................KIGWIGLGAMGTPMATRLRDAGLEVSVYNRTESKAAPLKEKGVAVYSPIDLAAKVDLVFTMLSDKAAIDAPKFWEQMSKKIVVNMSTIAPLESLSLEKIAQKHQATYLEAPVSGSVGAAKAGALLILAAGDEEVI........................................................................................... 140
15 -9.850IDP91227 gene: tyrA; T-protein [Escherichia coli CFT073] NT04EC3201 [Escherichia coli CFT073]  ali follow..  10  5..............................................................................................................................................................................................LTALRDQIDEVDKALLNLLAKRLELVAEVGEVKSRFGLPIEALGVPPDLIEDVLRRVMRESYSSENDKGFKTLCPSLRPVVIVGGGGQMGRLFEKMLTLSGYQVRILEQH------------DWDRAADIVSDAGMVIVSVPIHVTEQVGKLPPLPKDCILVDLASVKNGP-LQAMLAAHDGPVLGLHPMFGPDSGSLAKQVVVWCDGRKPLEQIQVWGARLHRISAVEHDQNMAFIQALRHFATFAYGLHLAE--ENVQLEQLLALSSPIYRLELAMVGRLFAQDPQYADIIMSSERNLALIK. 318
16 -9.820IDP02370 gene: fabG; 3-ketoacyl-(acyl-carrier-protein) reductase [Bacillus anthracis str. `Ames Ancestor`] GBAA1958 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  14  1..................................................................................................................................................................................................................................................................MLYLAELLQGKNALITGAGRIGRAVAIALAKEGVNVGLLARSEENLKAVAKEGVKAVIATADVSSYEEV-------TTAIETLKNGLGSIDILINNAGISKFGKFLELDVADWEKIIQVNLMGVYYATRAALPSMIEQQSGDIINISSTAGQKGAPVTSAYSASKFGVLGLTESLAMEVRKHNIRPSTVATDMAVDLGLTDGNPDKVMQAED-LKLNKRTFIKLWSTNP........ 242
17 -9.630IDP90877 oxidoreductase, zinc-binding dehydrogenase family [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj1548c [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  15  138...................................................................................................................................................................................................................TYGGYSNNIVVSEKFAVCVP-----KDAPMEKVAPLLCAGITTYSPLKFSN----EGSSVAVAGFGGLGMMAVKYAVKMGAKVSVFARNENKKADALAMGYTSCDKNAVKERFDLIISTIPTPYNPA-IYLDLLKFGGEMAIVGLPPHEVAPSISEMLDFSLKHGIYPETELITPQEIDKAYENLTSGKA.............................................................................................. 347
18 -9.470IDP00461 gene: tyrA; bifunctional chorismate mutase/prephenate dehydrogenase YPO3285 [Yersinia pestis CO92]  ali follow..  5..............................................................................................................................................................................................LTALRDQIDEVDKALLDLLAKRLHLVAEVGEVKSRYGLPIGALGVPPDLIEDVLRRVMRESYTSENDKGFKTLCPELRPVVIIGGQGQMGRLFSRMLNLSGYQVRTLEQE------------DWSQAESILADAGMVIVSVPIHITEEVNRLPKLPADCILLDLASVKNKP-LQAMLAAHEGPVLGLHPMFGPDVGSLAKQVVVYCDGRDPLEQLQVWGARLHRISAVEHDQNMAFIQALRHFATFAYGLHLAE--ENVQLEQLLALSSPIYRLELAMVGRLFAQDPQYADIIMSSEDNLALIK. 318
19 -9.330IDP00643 precorrin-2 dehydrogenase SACOL2638 [Staphylococcus aureus subsp. aureus COL]  ali follow..  23  9.........................................................................................................................................................................................................................................................................LTNKNVVIVGGGVVASRRAQTLNQYVEHMTVISPTITEKLQNMVDNGVVIWKEKEFEPSDILVIAATNEPRVNEAVKKALPEHALFNNVGDAS......................................................................................................................................... 105
20 -9.070IDP91958 Trk family potassium uptake protein [Streptococcus pneumoniae str. Canada MDR_19A] SpneCM_010100004562 [Streptococcus pneumoniae str. Canada MDR_19A]  ali follow..  17  1.........................................................................................................................................................................................................................................................................MSDRTIGILGLGIFGSSVLAALAKQDMNIIAIDDHAERINQFEPVLARGVIGDITIDTCDTVVVATGESSVLAVMHCKSLGVPTVIAKVKSQTAK....................................................................................................................................... 107

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Veeramalai M, Ye Y, Godzik A. TOPS++FATCAT: fast flexible structural alignment using constraints derived from TOPS+ Strings Model. BMC Bioinformatics. 2008 Aug 31;9(1):35