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Query: IDP02330 gene: ilvC-1; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1419 [Bacillus anthracis str. `Ames Ancestor`], from CSGID

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTVAEAAKQADVVMILLPDELQPEVYEEEIAPNLQAGNSLVFAHGFNVHFDQVKPPVNVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVATEKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYEGGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGTVLAEIQDGTFARGWIAEHKAGKPNFYATNEKENEHEIEVVGRKLRGMMPFVQPRVKAGVKLast
1 -32.800sp|P31937|3HIDH_HUMAN 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=HIBADH PE=1 SV=2  ali follow..  12  32.........CSRSVASKTPVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSPADVAEKADRIITMLPTSINAIEAYNGILKKVKKGSLLIDSSTID--------PAVSKELAKEVEKMGAVFMDAPVSGGARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKI----CNNMLLAISMIGTAEAMNLGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQTLMAKDLGLAQDSATSTKSPILLGSLAHQIYRMMCAKGYSKKDFSSVFQFLRE.......................... 332
2 -27.900sp|Q49A26|GLYR1_HUMAN Putative oxidoreductase GLYR1 OS=Homo sapiens GN=GLYR1 PE=1 SV=3  ali follow..  12  266...............TDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGTPAEVVSTCDITFACVSDPKAAKDLVSGVLQGIRPGKCYVDMSTVD--------ADTVTELAQVIVSRGGRFLEAPVSGNSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMML----IVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQ--NILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH.......................... 553
3 -24.500sp|P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens GN=PGD PE=1 SV=3  ali follow..  13  1..............MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKLKEMVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSE--------YRDTTRRCRDLKAKGILFVGSGVSGGGARYGPSLMPGGNKEAWPHIKTIFQGIAAKCDWVGDEGAGHFVKM----VHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWN........................................................................................................ 224
4 -19.800sp|Q96HN2|SAHH3_HUMAN Putative adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1  ali   27  233.......KRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKLNEVIRQVDI..................................................................................................................................................................................................................................................................... 300
5 -19.600sp|Q96HN2|SAHH3_HUMAN Putative adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1  ali   22  83.......KRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKLNEVIRQVDIVITCTGNK---NVVTREHLDRMKNSCIVCNMGHSNTEIDV............................................................................................................................................................................................................................. 187
6 -17.900sp|P23526|SAHH_HUMAN Adenosylhomocysteinase OS=Homo sapiens GN=AHCY PE=1 SV=4  ali follow..  21  204.......KRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCI---DIILGRHFEQMKDDAIVCNIGHFDVEID.............................................................................................................................................................................................................................. 307
7 -17.900sp|Q8NFT2|STEA2_HUMAN Metalloreductase STEAP2 OS=Homo sapiens GN=STEAP2 PE=1 SV=3  ali follow..  12  29...............RKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLW--DLRHLLVGKILIDVSNNMRINQYPESNAEYLASLFLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIEN................................................................................................................................................... 203
8 -17.500sp|O43865|SAHH2_HUMAN Putative adenosylhomocysteinase 2 OS=Homo sapiens GN=AHCYL1 PE=1 SV=2  ali follow..  23  303........RTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNK---NVVTREHLDRMKNSCIVCNMGHSNTEID.............................................................................................................................................................................................................................. 405
9 -16.300sp|Q658P3|STEA3_HUMAN Metalloreductase STEAP3 OS=Homo sapiens GN=STEAP3 PE=1 SV=2  ali follow..  16  27...............EAPKVGILGSGDFARSLATRLVGSGFKVVVGSRNPKRTARLFPSAAQVTFQEEAVSSPEVIFVAVFREHYSSLC--SLSDQLAGKILVDVSNPTEQEHLQHRESNAEYLASLFPTCTVVKAFNVLQAGPRDGNRQVPICGDQPEAKRAVSEMALAMGFMPVDMGSLASAWEVE.................................................................................................................................................... 202
10 -16.100sp|Q687X5|STEA4_HUMAN Metalloreductase STEAP4 OS=Homo sapiens GN=STEAP4 PE=1 SV=1  ali follow..  15  20.................ETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLL-PSGAEVLSYSEAAKKSGIIIIAIHREHYDFLT--ELTEVLNGKILVDISNNLKINQYPESNAEYLAHLV-VVKAFNTISAWALQSGALDASRQVFVCGNDSKAKQRVMDIVRNLGLTPMDQGSLMAAKEIE.................................................................................................................................................... 190
11 -15.200sp|Q53H96|P5CR3_HUMAN Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens GN=PYCRL PE=1 SV=2  ali follow..  18  2..........AAAEPSPRRVGFVGAGRMAGAIAQGLIRAGKHILASAPTDRNLCHFQALGCRTTSNQEVLQSCLLVIFATKPHVLPAVL-AEVAPVVTTEHILVVAAGVSLSTLEELLPPNTRVLRVLPNLPC-------VVQEGAIV-MARGRHVGSSETNLLQHLLEACGRCEE------VPEAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEG.............................................................................................. 224
12 -14.100sp|Q9UBQ7|GRHPR_HUMAN Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens GN=GRHPR PE=1 SV=1  ali follow..  14  151..............LTQSTVGIIGLGRIGQAIARRLKPFGVQRFLYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSTPATEGLCNKDFFQKMKETAVFINISRGDVVNQD-------------------DLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILP--HIGSATHRTRNTMSLLAANNLLAGLRGEPMPSELKL............................................................................................................................ 328
13 -13.400sp|Q6NXP6|CN148_HUMAN Pyrroline-5-carboxylate reductase-like protein C14orf148 OS=Homo sapiens GN=C14orf148 PE=2 SV=2  ali follow..  21  67.......GSLNSATPEEFKVGIIGGGHLGKQLAGTLLQLGPSLRISTRRPETLGELQKLGIKCFHNADLVSWADVIFLCC--PSQLPNICVEIYTSLEKASIVYFVAAIPL................................................................................................................................................................................................................................. 175
14 -12.000sp|P56545|CTBP2_HUMAN C-terminal-binding protein 2 OS=Homo sapiens GN=CTBP2 PE=1 SV=1  ali follow..  13  178..............IRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEK-------------------ALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNL---TPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSAPWSVIDQQA......................................................................................................... 375
15 -11.900sp|Q13363|CTBP1_HUMAN C-terminal-binding protein 1 OS=Homo sapiens GN=CTBP1 PE=1 SV=2  ali follow..  15  172..............IRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQDLLFHSDCVTLHCGNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEK-------------------ALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNL---TPHAAWYSEQASIEMREEAAREIR.......................................................................................................................................... 336
16 -11.700sp|P30043|BLVRB_HUMAN Flavin reductase OS=Homo sapiens GN=BLVRB PE=1 SV=3  ali follow..  18  1..............MAVKKIAIFGAGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVDVDKTVAGQDAVIVLLGPTTVMSEGARNIVAAMKAHGVVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLK.................................................................................................................................................................................................. 145
17 -11.600sp|Q16836|HCDH_HUMAN Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens GN=HADH PE=1 SV=3  ali follow..  14  19........SASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKG--TSTDAASVVHSTDLVVEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSL---------QITSIANATTRQDRFAGLHFFNPVPVMKLVEVIKTTSQKTFESLVDFSKALGKHPVSCKDTGFIVNRLLVPYLMEAIRLYERGDASKEDIDTAMKLGAG..................................................................................................................... 253
18 -11.300sp|A6ND91|ASPD_HUMAN Putative L-aspartate dehydrogenase OS=Homo sapiens GN=ASPDH PE=2 SV=2  ali follow..  19  1MAD------------GPWRVGVVGYGRLGQSLVSRLLAQGPEVFVWNRDPGRMAGSVPPSLQLQNLAALGERPDLVVEVAHPKIIHESGAQ----ILRHANLLVGSPSA------LSDQTTERQLLEASQHWDHAV........................................................................................................................................................................................................ 121
19 -10.900sp|Q9UDR5|AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Homo sapiens GN=AASS PE=1 SV=1  ali   20  20......ERAQSLSMGTRRKVLVLGSGYISEPVLEYLRDGNIEITVGSDMKNQIEQLGKK--QEEKLGFLVAKQDLVISLLPYVLHPLVAKACITNKVDAGITIIGELGLDPGLDHMLAMETIDKA................................................................................................................................................................................................................... 169
20 -10.900sp|P53004|BIEA_HUMAN Biliverdin reductase A OS=Homo sapiens GN=BLVRA PE=1 SV=2  ali follow..  13  1.........MNAEPERKFGVVVVGVGRAGSVRMRDLRNPSSAFLNLIGFVSRRELGSIDGVQQISLEDALSSQEVAYICSESSSHEDY----IRQFLNAGKHVLVEYPMTLSL------AAAQELWELAEQKGKVL........................................................................................................................................................................................................ 121
21 -10.900sp|Q13423|NNTM_HUMAN NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3  ali   18  61FGRFFTGQITAAGKVPPAKILIVGGGVAGLASAGAAKSMGAIVRGFDTRAAALEQFKSLGAEPLEFAQQCKEVDILIALIPGKKAPVLFNKEMIESMKEGSVVVDLA..................................................................................................................................................................................................................................... 197
22 -10.800sp|O43175|SERA_HUMAN D-3-phosphoglycerate dehydrogenase OS=Homo sapiens GN=PHGDH PE=1 SV=4  ali follow..  11  143..............LNGKTLGILGLGRIGREVATRMQSFGMKTIGYD---ISPEVSASFGVQQLPLEEIWPLCDFITVHTPLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEG-------------------ALLRALQSGQCAGAALDVFTEEPPRDRA-LVDHENVISCP--HLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNA............................................................................................................................ 318
23 -10.700sp|Q08426|ECHP_HUMAN Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3  ali   11  148.................SSVGVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKM--RLTSSVKELGGVDLVIEAVFEEMSLKQVFAELSAVCKPEAFLCTNTSA................................................................................................................................................................................................................................... 262
24 -10.700sp|Q08426|ECHP_HUMAN Peroxisomal bifunctional enzyme OS=Homo sapiens GN=EHHADH PE=1 SV=3  ali   11  1....................GVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKM--RLTSSVKELGGVDLVIEAVFEEMSLKQVFAELSAVCKPEAFLCTNTSA-----------DVDEIASSTDRPHLVIGTHFFSPAHVMKLLEVIPSSSPTTIATVMNLSKKIKKIGVVVGNCF-------------GFVGNRMLNPYYNQAYFLLEEGSKPEEVDQVLEE........................................................................................................... 211
25 -10.500sp|O60701|UGDH_HUMAN UDP-glucose 6-dehydrogenase OS=Homo sapiens GN=UGDH PE=1 SV=1  ali follow..  12  1.............MFEIKKICCIGAGYVGGPTCSVIAHMCIRVTVVDVNESRINAWNSPTLPITNIDDAIKEADLVFISVNDLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELKLAANAFLAQRISSINSISALCEATGADVEEVATAI............................................................................................................. 255
26 -10.200sp|P40939|ECHA_HUMAN Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens GN=HADHA PE=1 SV=2  ali   11  39LMGLYHGQVLCKKNKFGKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQ-LTGQLDYQGFEKADMVIEAVFEDLSLKRVLKEVEAVIPDHCIFASNTSA-----------PISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTTSKDTSASAVAVGLKQG-------------KVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKL................................................................................................................. 271
27 -9.210sp|P21695|GPDA_HUMAN Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic OS=Homo sapiens GN=GPD1 PE=1 SV=4  ali follow..  15  1..............MASKKVCIVGSGNWGSAIAKIVGGNDPRVTMWVFEEDIGGKKLTEIINVPDVVQAAEDADILIFVVPHQ-FIGKICDQLKGHLKANAGISLIKGVDEGPNGLKLISEVRLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKELMQ-------------TPNFRITVVQEVDTVE--ICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAF................................................................................................... 238
28 -9.180sp|P40939|ECHA_HUMAN Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens GN=HADHA PE=1 SV=2  ali   18  189LMGLYHGQVLCKKNKFGKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQ-LTGQLDYQGFEKADMVIEAVFE.............................................................................................................................................................................................................................................................. 300
29 -9.020sp|Q9UDR5|AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Homo sapiens GN=AASS PE=1 SV=1  ali   16  170......ERAQSLSMGTRRKVLVLGSGYISEPVLEYLRDGNIEITVGSDMKNQIEQLGKK--QEEKLGFLVAKQDLVISLLPYVLHPLVAKA-----ITNKVNMVTASYIT---------PALKELEKSVEDAGITIIGE..................................................................................................................................................................................................... 300
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.