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Query: IDP92131 alanyl-tRNA synthetase, putative [Toxoplasma gondii ME49] TGME49_019540 [Toxoplasma gondii ME49], from CSGID

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAMTEEERRAKIEEISAKGKAKGWSGEAVRGAYLEFFEAQGHLIYPSSPVIPRGDNTLLFINAGMNQFKPIFLGQIDRSSPLSKLRRVADTQKCIRAGGKHNDLEDVGKDVYHHTFFEMLGNWSFGDYFKREAIAWAWQLLTEVYKIPKDRLYASYFGGDPRLPSCPPDEEARDIWLQYLPANRVLPFGAKENFWEMADTGPCGPCSEIHYDRIGGRDASSLVNADDPSVLEIWNLVFMQYNREKDGSLTPLPAPCVDTGMGLERVASVLQDKQSNYDTDLFTALFDKILELSPGLRPYGGKVGEEDKDMVDMAYRVLADHARCLTAAIADGAEPSNEGRGYVLRRILRRAVRYARQTLGMAEGNFPKLVPVVVSLLGETFPEMKKNEEKVVRILLKEEQQFSRTLDNGVERFKKVANSLQAKGQKVFPGGEAFTLYSTYGFPLDLTQLMAEEVGLQVDAEEFERKFDAHRAASENTSFKQGGAGAVYALPPDQRHLLAQSRKVPPTDDSAKYEWNVKDQAALMTQDAVEAAPIKAKVMAIWDGKRFAPEVTAVASPTGENLVAVILDKTCFYAEQGGQIGDVGRLVDLSSQAEFEVVDSQKSGDFILHIGSMSKGTLREGTELVPAVDYVRRFRLAQHHTGTHLLNFALREVLIRKLRSGGKASANGDKREDTNGIRICESCLNEKELEDGEDIQQKGSLVEVKRLRFDYAGEKPLENEDIIAVENVVKDCIAQARPVHYKEVPLEQAMKIPGLRAVFGEVYPDPVRVVSVGEDIESLVALADSSQPETPFASIELCGGTHLHNASQLSDFCILSEESVAKGVRRVVAAAGDAAFEARKELEELEEAFRSLASAPRELAALEKEVAKARGLLDGAGPLPLVGKRSLVKQLEQAQKALLELQKARSKELVKEAKKLGEELGTEHKTKPFLVLNLPQLLGDGKALDAASQTLHQAAPDLPFLLVTASAATGTAAIAFVPAACSQLHAASWLTACVGLLGGKGGGKGERAVGAAKEGAADKVDAAVAEATAFAEKKYGALast
1 -113.000sp|P49588|SYAC_HUMAN Alanyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=AARS PE=1 SV=2  ali   57  1...................MDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMAKLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIPIERLYVTYFGGDEAA-GLEADLECKQIWQNGLDDTKILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRDAAHLVNQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFVPYFEAIQKGTGARP------------YTGKVGAEDADGIDMAYRVLAD.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 300
2 -106.000sp|Q5JTZ9|SYAM_HUMAN Alanyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=AARS2 PE=1 SV=1  ali   58  15.AIRRSPAWRGLSHRPLSSEPPAAKASAVRAAFLNFFRDRGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVANSQKCVRAGGHHNDLEDVGRDLSHHTFFEMLGNWAFGEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDPKA-GLDPDLETRDIWLSGVPASRVLSFGPQENFWEMGDTGPCGPCTEIHYDLAG--------GVGAPQLVELWNLVFMQHNREADGSLQPLPQRHVDTGMGLERLVAVLQGKHSTYDTDLFSPLLNAIQQGC........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 300
3 -98.300sp|P49588|SYAC_HUMAN Alanyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=AARS PE=1 SV=2  ali   58  1..........................................................................................................................................................................ECKQIWQNGLDDTKILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRDAAHLVNQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFVPYFEAIQKGTGARP-YTGKVGAEDADGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRILRRAVRYAHEKLNASRGFFATLVDVVVQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQSLG--DSKTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQ...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 299
4 -97.400sp|Q5JTZ9|SYAM_HUMAN Alanyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=AARS2 PE=1 SV=1  ali   48  1.......................................................................................................................................MAWELLTQVYGIPEERLWISYFDGDPKA-GLDPDLETRDIWLSGVPASRVLSFGPQENFWEMGDTGPCGPCTEIHYDLAG--------GVGAPQLVELWNLVFMQHNREADGSLQPLPQRHVDTGMGLERLVAVLQGKHSTYDTDLFSPLLNAIQQGCRAPP-YLGRVGVADEGRTDTAYRVVADHIRTLSVCISDGIFPGMSGPPLVLRRILRRAVRFSMEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLGPSDMFPAEVAWSLSLCGDLGLPL................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 300
5 -76.300sp|P49588|SYAC_HUMAN Alanyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=AARS PE=1 SV=2  ali   39  2............................................................................................................................................................................................................................................................................................................................................................................................................................................................SQGKGAGGEDLIMLDIYAIEELRARGLEVTDDSPKYNYH---------------------------------------LDSSGSYVFENTVATVMALRREKMFVEEV------STGQECGVVLDKTCFYAEQGGQIYDEGYLVKVDDSTEFTVKNAQVRGGYVLHIGTI-YGDLKVGDQVWLFIDEPRRRPIMSNHTATHILNFALRSVLG--------------------------------------EADQKGSLVAPDRLRFDFTAKGAMSTQQIKKAEEIANEMIEAAKAVYTQDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVSEL--LDDPSGPAGSLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIR.................................................................................................................................................................................................................... 300
6 -73.800sp|P49588|SYAC_HUMAN Alanyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=AARS PE=1 SV=2  ali   42  1................................................................................................................................................................................................................................................................................................................................HARTITVALADGGRPDNTGRGYVLRRILRRAVRYAHEKLNASRGFFATLVDVVVQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQSLG--DSKTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQGKGAGGEDLIMLDIYAIEE----LRARGLEVTDDSPKYNYH------LDSSGSYVFENTVATVMALRREKMFVEEV------STGQECGVVLDKTCFYAEQGGQIYDEGYLVKVDDSTEFTVKNAQVRGGYVLHIGTI-YGDLKVGDQVWLFIDEPRRRP.................................................................................................................................................................................................................................................................................................................................................................................................................. 300
7 -73.500sp|Q5JTZ9|SYAM_HUMAN Alanyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=AARS2 PE=1 SV=1  ali   35  4.........................................................................................................................................................................................................................................................................................................PYLGRVGVADEGRTDTAYRVVADHIRTLSVCISDGIFPGMSGPPLVLRRILRRAVRFSMEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLGPSDMFPAEVAWSLSLCGDLGLPLDMVELMLEEKGVQLDSAGLERLAQEEAQHRARQAEPVQKQGLWLDVHALGE---LQRQGVPPTDDSPKYNYS------LRPSGSYEFGTCEAQVLQLYTEDG-----TAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVRAGQEVLFPVARAQVCGGFI.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 300
8 -67.100sp|Q5JTZ9|SYAM_HUMAN Alanyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=AARS2 PE=1 SV=1  ali   33  1............................................................................................................................................................................................................................................................................................................................................................................................................................................................DMVELMLEEKGVQLDSAGLERAQEEAQHRARQAEPVQKQGLWLDVHALGE----LQRQGVPPTDDSPKYNYS------LRPSGSYEFGTCEAQVLQLYTEDG-----TAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVRAGQEDVLFPVARAQVCGGFILHEAVAPECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPG-------------------------------------TEQQGSHLNPEQLRLDVTTQTPLTPEQLRAVENTVQEAVGQDEAVYMEEVPLALTAQV-PGLRSLDEVYPDPVRVVSVGVPVAHA----DPASQAALQTSVELC............................................................................................................................................................................................................................................... 299
9 -66.400sp|Q5JTZ9|SYAM_HUMAN Alanyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=AARS2 PE=1 SV=1  ali   26  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LHEAVA-PECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPG-------------------------------------TEQQGSHLNPEQLRLDVTTQTPLTPEQLRAVENTVQEAVGQDEAVYMEEVPLALTAQV-PGLRSLDEVYPDPVRVVSVGVPVAHAL---DPASQAALQTSVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEVKAATERLSLGSRDVAEALRLS----------------------------KDIGRLIEAVETAVMPQWQRRELLATVKMLQRRANTAIRKLQMGQAAKKTQELLERHSKGPLIVDTVSAESLSVLVKV............................................................. 299
10 -64.700sp|P49588|SYAC_HUMAN Alanyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=AARS PE=1 SV=2  ali   34  1...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IMSNHTATHILNFALRSVLG--------------------------------------EADQKGSLVAPDRLRFDFTAKGAMSTQQIKKAEEIANEMIEAAKAVYTQDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVSEL--LDDPSGPAGSLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKAESLKKCLSVMEAKVKAQTAPNKDVQREIADLGETAVIPQWQKDELRETLKSLKKVMDDLDRASKADVQKRVLEKTKQFIDSNP-NQPLVILEMESGASAKALNEALKLFKMHSPQTSAMLFTVDNEAGKIT................................................................ 300
11 -54.200sp|Q9BTE6|AASD1_HUMAN Alanyl-tRNA editing protein Aarsd1 OS=Homo sapiens GN=AARSD1 PE=1 SV=2  ali follow..  20  13....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EFTTTVVSCCPAELQTEGSN--GKKEVLSGFQVVLEDTVLFPEGGGQPDDRGTIND------ISVLRVTRRGEQADH---FTQTPLDPGSQVLVRVDWERRFDHMQQHSGQHLITAVADHLFKLKT---------------------------------------TSWELGRFRSAIEL-DTPSMTAEQVAAIEQSVNEKIRDRLPVNVRELSLDDPEVEQVSGRGLPDDHAGPIRVVNIEG------------------VDSNMCCGTHVSNLSDLQVIKILGTEKGKKNRTNLIFLSGNRVLKWMERSHGTEKALTALLKCGAE---------------------------DHVEAVKKLQNSTKILQKNNLNLLRDLAVHIAHSLRN--SPDWGGVVILHRKEGDSEFMNIIANEIGSEETLLFLTVGDEKGGGLFLLAG------PPASVETLGPRVAEVLEGKGAGKKGRFQGKATKM--SRRMEAQALLQDYISTQSA. 410
12 -45.600sp|Q5JTZ9|SYAM_HUMAN Alanyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=AARS2 PE=1 SV=1  ali   17  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEVKAATERLSLGSRDVAEALRLSKDIGETAVMPQWQRRELLATVKMLQRRANTAIRKLQMGQAAK-----KTQELLERHSKGPLIVDTVSAESLSVLVKVVRQLCEQAPSTSVLLLSPPMGKVLCACQVAQGAMPTFTAEAWALAVCSHMGGKAWGSRVVAQGTGSTT---DLEAALSIAQTYALSQL.. 235
13 -35.100sp|P49588|SYAC_HUMAN Alanyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=AARS PE=1 SV=2  ali   24  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RIVAVTGAEAQKALRKAESLKKCLSVMEAKVKAQTAPNKDVQREIADLGATAVIPQWQKDELRETLKSLKKVMDDLDRASKADVQKRVLEKTKQFI-DSNPNQPLVILEMESGASAKALNEALKLFKMHSPQTSAMLFTVEAGKITCLCQVPQNAARGLKASEWVQQVSGLMDGKGGGKDVSAQATGKNV--GCLQEALQLATSFAQLRLGD 215
14 -29.000sp|P26639|SYTC_HUMAN Threonyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=TARS PE=1 SV=3  ali   11  6..........................................................................................................................................................................................................................................................................................................................................................................................................................................................ASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEY--------------------------------YTRLEMYNILKAEHDSI-----------LAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTV--IAKVNNVVWDL----DRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGC-------------------------------------LCYGPPIENGFYYDMYL-EEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAM-FKYNKFKCRILNEKV--------------TPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTMETLQRIYGI............................................................................................................................................................................................................... 300
15 -14.100sp|Q9BW92|SYTM_HUMAN Threonyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=TARS2 PE=1 SV=1  ali   15  64........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SLPGGQKIDAVAWNTTPYQLARQISSTLADTAVAAQVNGEPYDLERPLETDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPVLERICQELTAAARPFRRLEASRDQLRQL--LHLIEEKVTGPTATVYGCGT-------------------LVDLCQGPHLRHTGQIGGLKLLSNSSSPETLQRVSGIS.............................................................................................................................................................................................................. 280
16 -9.720sp|A2RTX5|SYTC2_HUMAN Probable threonyl-tRNA synthetase 2, cytoplasmic OS=Homo sapiens GN=TARSL2 PE=1 SV=1  ali   12  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IYGKKGDTSNIITVRVADGQTVQGEVWKTTPYQVAAEISQELAESTSSLELLTFDNEEAQAVYWHSSAHILGEAMELYYGGHLCYGPPIEN-GFYYDMFIEDRAVSSTELSALENICKAIIKEKQPFERLEVSKEILLEM--CRILNEKVNTATTTVYRCGP--------------------IDLCKGPHVRHTGKIKTIKIFKNSSTMETLQRIYGIS.............................................................................................................................................................................................................. 230
17 -9.190sp|P26639|SYTC_HUMAN Threonyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=TARS PE=1 SV=3  ali   14  5....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HSSAHIMGEAMERVYGGCLCYGPPI--ENGFYYDMYLEEGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAM-----FKYNKF--KCRILNEKVNTPTTTVYRCGP--------IDLCRGPHVRHTGKIKALKIHKNSSTMETLQRIYGI----SFPDPKMLKEWEKFQEEAKNRDHRKIGRDQEL........................................................................................................................................................................... 182
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.