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Query: IDP92131 alanyl-tRNA synthetase, putative [Toxoplasma gondii ME49] TGME49_019540 [Toxoplasma gondii ME49], from CSGID

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAMTEEERRAKIEEISAKGKAKGWSGEAVRGAYLEFFEAQGHLIYPSSPVIPRGDNTLLFINAGMNQFKPIFLGQIDRSSPLSKLRRVADTQKCIRAGGKHNDLEDVGKDVYHHTFFEMLGNWSFGDYFKREAIAWAWQLLTEVYKIPKDRLYASYFGGDPRLPSCPPDEEARDIWLQYLPANRVLPFGAKENFWEMADTGPCGPCSEIHYDRIGGRDASSLVNADDPSVLEIWNLVFMQYNREKDGSLTPLPAPCVDTGMGLERVASVLQDKQSNYDTDLFTALFDKILELSPGLRPYGGKVGEEDKDMVDMAYRVLADHARCLTAAIADGAEPSNEGRGYVLRRILRRAVRYARQTLGMAEGNFPKLVPVVVSLLGETFPEMKKNEEKVVRILLKEEQQFSRTLDNGVERFKKVANSLQAKGQKVFPGGEAFTLYSTYGFPLDLTQLMAEEVGLQVDAEEFERKFDAHRAASENTSFKQGGAGAVYALPPDQRHLLAQSRKVPPTDDSAKYEWNVKDQAALMTQDAVEAAPIKAKVMAIWDGKRFAPEVTAVASPTGENLVAVILDKTCFYAEQGGQIGDVGRLVDLSSQAEFEVVDSQKSGDFILHIGSMSKGTLREGTELVPAVDYVRRFRLAQHHTGTHLLNFALREVLIRKLRSGGKASANGDKREDTNGIRICESCLNEKELEDGEDIQQKGSLVEVKRLRFDYAGEKPLENEDIIAVENVVKDCIAQARPVHYKEVPLEQAMKIPGLRAVFGEVYPDPVRVVSVGEDIESLVALADSSQPETPFASIELCGGTHLHNASQLSDFCILSEESVAKGVRRVVAAAGDAAFEARKELEELEEAFRSLASAPRELAALEKEVAKARGLLDGAGPLPLVGKRSLVKQLEQAQKALLELQKARSKELVKEAKKLGEELGTEHKTKPFLVLNLPQLLGDGKALDAASQTLHQAAPDLPFLLVTASAATGTAAIAFVPAACSQLHAASWLTACVGLLGGKGGGKGERAVGAAKEGAADKVDAAVAEATAFAEKKYGALast
1 -143.000PF01411.19; SYA_HAEIN/6-555; tRNA synthetases class II (A)  ali follow..  41  1...........................EIRQSFLDFFHSKGHQVVESSSLVPENDPTLLFTNAGMNQFKDVFLGMDKRP-----YSRATTAQRCVRPGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKQDAINFAWEYLTQWLGLPKEKLWVTVYETDDEAYNIWNKD-------VGVPAERIIRIGDNDNFWAMGDTGPCGPCTEIFYDHGDHGGPPGSPEEDGDRYIEIWNVVFMQFNRLADGTMEKLPRPSVDTGMGLERISAVLQHVNSNYEIDIFKTLIAKTAEIVGATD------------LTNKSLRVIADHIRSCAYLIADGVIPSNEGRGYVLRRIIRRAVRHGHL-LGAKESFFYKLVPTLIDVMAEAGKDVKAKQTNVEKLLRLEEEQFARTLERGLSLLDEALSQV---KDGILSGEVAFKLYDTYGFPLDLTADVCRERNITIDEQAFDRKMEAQRTRAQAASQFGVDYN------------------------------SVIRVDGETKFEGYTEVESQAKITALFYDGKSVESI------EAGQSAVVILENTPFYAESGGQIGDSGYLSTQS--VTFNVKDTQKYGQVFGHIGELTQGSLKVGQSVNAIVDAKR..................................................................................................................................................................................................................................................................................................................................................................................................................... 550
2 -53.600PF02091.15; SYGA_PELCD/3-280; Glycyl-tRNA synthetase alpha subunit  ali follow..  17  2..........................QELILALQNYWAKQGCIIQQPYDMEK---------GAGTFNPA-TFLRVLGPEP-----WNVAYVEPSRRPDGRY--GENPNRLQHYYQFQVVMK------PSPTNIQELYLDSLKSF-GISPSRHDIRF----------------------------------VEDDWESPTLGAWGLGWEVWLD------------------MEITQFTYFQQVGG-----IDLKPVSAEITYGCERIAMYLQGVDNVYDLEWYGDVHHQSEVEYSTYNFEEADAGM-KSQLVLPAYDYVLKASHAFNLLDARGAISVTERAHYIGR--VRNLARLCAEG....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 272
3 -8.970PF17072.5; SPIKE_BRV1/1-1583; Torovirinae spike glycoprotein  ali follow..  13  557LAQSSVYQPSMFNMGVNKSVTLTTQLQAYAQVYTAWFLSILYTRLPESR---------LTLGAQLTPFIQALLSFKQADIDATDVDTVARYNVLILMWGRYNQLPEIHQTASHFPF--IAGYLDFLDYYKDVACPLSTMVPSILQVYETPQLFVIIVQCVSTTYS----------WYPGLRNPHTI------RSYKLGTI-PYSSPTDVYSSFG--QSALTIPTVQTTDDILPGCVGFVQ-----DSVFTPCHPSGCPVRNSYDNYIICPGSSASNYTTNVPIEEVPLQLEIPTVSLTSYELKQSESVLLQDIEGGIVVDH--------NTGSIWYPGGQAYDVSFYVSVIIRYAPPKLELPSTLAN--FTSCLDYICFGNQQCRGEAQTFCTSMDYFEQVFNKSLTSLITALQDLHYVLK------------LVLPET---TLELTEDTRRRRRISLLSESFERFMSPASQAYMANMMWWDEAFDGISLPQRTGSILSSAPSLSSISSWHSYSSSTLSTIGSVLSSGLSIASLGLSIFSIIEDRRVIELTQQQIMALEDQITILAGYTTKNFEEIQSSLNTLGQQVQDFSQTSALSLQQLSNG-----------------EQITQQLDKSIYYVMAVQQYATYMLSQAVYKTQDMYITCIHSLQSGVLSPNCITPFQICHLYQVAKNLSSGEEISRFYSLVTDAMVHNDFSWSIPITCSNILGSVYKVQPIVNPHHPTSLQYDVPTHVVTSNAGALIFDEHYCDRYNQVYL......................................................................................................................................................................................................................................................................... 1367
4 -8.630PF05088.12; A4XWG7_PSEMY/77-1608; Bacterial NAD-glutamate dehydrogenase  ali follow..  11  594...........................................................................................................................AYARYLKQIRLGFDLSYIASTLINHADRLFRTRFYLARKLTAEDLEDKQQKL-VAVLNEDRILRR--RTNFFQADASG---PKFEIFV----ARGGLRWSDREEDFRTEVLGLVKAQQVKNAVGAKGGFVPRKMPVGGSRDEVMAEGIACYRIF----ISGLLDITDNLKEGEVVPPVNV---RHDADDPYLVVAADK----TATFSDIANGIAAEYGFWLGDAFAGSAGYDHKGMGITAKGGWVSVQRHFRERG----------------IDVQKDNV-TVIGIG------------------MAG-------DVFGNGMLLSDKLFNHMHIFIDPNPDAAKSFAERKRLFDLPRSSWADYDSKLISEGGGIFLRSAKSITITPQMKARFDIAADKLAPTELLN-ALLKAPVDLLWNGGIGTYVKSSKESHADVGDKANDAL--RAKVVGE-GGNLGQLGRVEFGLHGGASNTDFIDNAGGVDCSDHEVNIKILLGEIVSGGDMTEKQRNKLLAEMT-----DDVSELVLGNNYKQTQALSLAERRARERVGEYKRLMNALESAGKLDRALE---FLPSDEELNERATNGQGLTRPELSVLISYSKIDLKESLKSLVPDDDYLAREMETAFPEILTEKFGDAMRRHRLKREIVSTQIANDLVNHMGITFVQRLKESTGMSAANVAGAYVIVRD-RLPHWWAQIEALDYKVPAELQLQLMDELMRLGRFLRSRRNELDAARDVAHFAPRIEADELLEGPAREQWLARYQSFVEAGTPEELARVVAGTSHLYTLLPIIEAADVTG-ATAYFAVGGALELSWYLQQITNLPVETNWQALAREAFRDDLDWQQRAITVSVLQMAEGPQEIEARVA.......................................... 1492
5 -7.550PF06016.11; VP1_AQRVC/1-1298; Reovirus core-spike protein lambda-2 (L2)  ali follow..  12  6...............................................................GIQLVPKLNTSTTRRTFLPLRFDLLLDRLQSLDFNPVDRSATVI------QTYPPLNAPLDYRDWFIHDRALAFVGVLTQRYPLSIDIFLDRLFYGPTQESPITSITKFPYQWTIDFNVTARTPAGCKYGYDPSRPSTPA-TYATVFYYSTLPARSRLLANLAAG------PTVLEHFDSPTYGPHLLLPQTGDVLGYSLLMVESVMDALRDNANASASTAVTRLDQSYHPVTSFDPSTFNT------------LLQRATNLALLAVQGVIPTMSDVRSFVARLMAEG-RVDQILYWPESPFVPPIGPFYAPFRPVNFPTVVPDASRPLRLLPQYRNATITVQQADDAYEDTALSPLITTHGFCVTGGVSTSIYDISGDPTAYPPAQLVD----TPNDYFDRERMARRDLFRRLRAPADRSAIKDRAVFDFLASLVNPTT----------ANPVLDTSFSMAYLGASSAHANADILADIRSGSIPGLPIPRRIVQFG------------YDVVHGSLLDTGTVYADLDQVEDAGTDMPAANRAAIAMLGTALQMTTAGGVSVLKVNFPTRNLYATHATTLHLVKPTIVNVFGGRQSNGALRSTTALQRALLSLYARNAAIDRAVTHI--GVPDDGTSDLGIDAVRLDPMFSDAVANLPSNALASLVSRVVPSSIMFTRVPSNGPVSTTIYGKRTFLSNRRRARLRDVPMLITTTLVHQRRFTTPPTFTLFSSEVAAGYNSFISEQTRNPNLAHLLDLGTGPERILSLIPPTLQVTMSDARPCAELMASFDPALTAYVQGD---CDSATAIFTLGAAAAAAGTDLIAFVQQLIPRIVAAGGTRMWLQLNTPLYEVSSLPDLIDIDLRDRVYRFNGGERVEDPVPLQQAIAALLPAAALSWHTLSPTCDWLPYIIGVGSPLNLSDINTAISYSRLT........................................ 1023
6 -7.460PF07973.14; SYT2_BACSU/172-221; Threonyl and Alanyl tRNA synthetase second additional domain  ali follow..  24  10..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VDLCRGPHLPSTGMIKAFKLTRVSGANEVLQRV.................................................................................................................................................................................................................. 49
7 -7.040PF10266.9; H2R9P1_PANTR/23-1103; Hereditary spastic paraplegia protein strumpellin  ali follow..  8  6..........................................ELLRLSEFIPAV------DRADQQKYGDIIF-------DFSYFKGPELWESKLDAKPELQDLDE----EFRENNIEIVTRFSVHKYIVD---------LNRYLDDLNEGVYI-----QQTLETVLLNEDGKQLLCEALYLYGVMLLVIDQKI---------GEVRE----------------------------MLVSYYRYSAARSSADSN--------MDDICKLLRSTPSNYPESYFQRVISMVIGRLRSDDIYNQVSAYPLPEHRSTALANQAAMLYVILYFEPS------HTHQAKMREIVDK----------FPDNWVISIYMGITVNLVDAWEPYKAAKTALNNTLDLSNSRYATVSERVHAQVQQFLKEGYLREEMVLDN-------------IPKLLNCLRDCNVAIRWLMLHTADSACDPNNKRLRQIKDQILTDSRYNPRILFQLLLDTAQFEFILKEMFKQMLSEKQTKWEHYKKEGSERMTELADVFSGVKPLTRVEKNENLQA------------WFREISKQILS-------------------------LNYDDSTAAGRKTVQLIQALEEVQEFHQLESNLQVCQFLA-DTRKFLHQMIRTINIKEEVLITMQIVGDLSFAWQLIDSFTSIMQESIRVNPSMVTKLRATF-LLRINQANSPDLLSVSQYYSGELVSYVRKVLQIIPESMFTSLLKIIKLQTHDIIEVPTRLDKDKLRDYAQLGPRYEVAKLTHAISIFTEGILMMKTTLVGIIKVDPKQLLEDGIRKLHRGLIFNPRAKPSELMPKLKELGATMDGFHRSFEYIQDYVNIYGLKIWQEEVSRIINYNVEQECNNFLRTKIQDWQSMYQSTHIPIPKFTPVDESVTFIGRLCREILRITDPKMTCHIDQLNTWYDMKTHQEVTSSRLFSEIQTTLGTFGLNGLDRLLCFMIVKELQNFL........................................ 870
8 -6.600PF09276.10; TOX5_BORPE/37-133; Pertussis toxin S5 subunit  ali follow..  16  1.......................................................PTHLYKNFTVQELALKLKGKNQEFCLTAFMSGRSLVRACLSDAGHEHD-----------TWFDTMLGFAISAYALKSRIALTVE.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 73
9 -6.380PF01780.19; C4M0M9_ENTHI/4-88; Ribosomal L37ae protein family  ali follow..  11  2.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TKKVGIVGKYGTRYGASLR-----------KVIKKIEIAQHSKYVCPFCCKEAVRRTA-CGIWECKGKKQIAGGAYTLSTISGATVRSTVRRLRD................................................................................................................................................................................................. 85
10 -6.350PF06317.11; L_TACVF/179-2207; Arenavirus RNA polymerase  ali follow..  8  7.....................................................................................................................................................QRLIHSLSNVRNQSLGF-------------------------ENIECLKRNL-----DRLAKSLFVGVKGDVRESVIREELMKLRLWYKKEVFDKNLGKFRITNRSEL-----LNNLIRLGKHEDNTTSDFCVNKFMDIIYSLTFTALKRQDREKSNSELDQYVVCPHEKAYLGVLSIC--------NKIKGLKVFNTRRN------TLLFLDLIMVNFLDDLFTAKLGQMVTLVNDRALDFLEAVK----LIKKKIETNVKWVENCSKILRRSQQDIWSQISVWARYPDLSKLISIAQTISSDR-MRYSAGGNFNTECKHKTFHMMSDAEQVEAFKILSSVSLSLINSMKTSFSSRLNEKEYSRYFGNVRLRECYQQRFFLTDGLIVILFYQKTGERSGSIYTCEDGVLVEKGSFYCDPKRFFL----PIFSQEVLVEMCDEMTTWLDFNSDLMVISKEKLRLLLLSILCAPSKRNQV-QGLRYFLMAYSNQFHLAVDLFQCLLGEGVDSDPYFARR---KYLLNVSYLCHLITKETPDRLTDQIKCFEKFIEP-KIDFN-SLNGQLTEAQEGMMLDGLDKFYSKTLKDCSDTKL-----------GVSNELLSYCISLFNKGKLKVTGELKNDPFKPNITSTALDLSSNKSVVVPKLDELGNVLSVYDREK----ISSCVSSMAERFKTKGRYNIDPSTLDYLILKNLTGLVSIGSKTQRDCEELSMMFEGLTEEQAEAFNDIKNSVQLAMVKMKDSKSGDVNLSPNQKEGRVKSSTGTLEELWGPFGIMREIRT........................................................................................... 782
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.