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Query: IDP02330 gene: ilvC-1; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1419 [Bacillus anthracis str. `Ames Ancestor`], from CSGID

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTVAEAAKQADVVMILLPDELQPEVYEEEIAPNLQAGNSLVFAHGFNVHFDQVKPPVNVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVATEKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYEGGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGTVLAEIQDGTFARGWIAEHKAGKPNFYATNEKENEHEIEVVGRKLRGMMPFVQPRVKAGVKLast
1 -56.100[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  30  23MDR--EEFADEANFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEASFQRATENGFKVGTYEELIPTADLVVNLTPDKQHSKVV-ADVMPLMKKDSAFGYSHGFNIVEVGEEIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPDPKGEGMAIAKAWAAATGGHKAGVLESSFVAEVKSDYFDNGVLMIAMVKAGVELAFDAMVASGIYEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSNVAT----PILAKEIIPNLQKGDLGEPTP-AVEVDNITLRDVNDAIRNHPVELIGQELRGYMTDMKRIAVAG.. 492
2 -32.300[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  17  2.................ETIGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLADLVAKGLKTVGHAAVAKAADIIITMVPDTPQVADVLNGVASGLTRGKLVIDMSSIS--------PIETKVFAGKINELGCDYLDAPVSGGAKAASLTIMVGGEEKAFERAKPVFEKMGKNITLVGPNGVGQTTKV----ANQIVVALTIEAVAEALVFASKAGADPARVRQALMGGLAASRILEVHGE--RMVKRTFAPGFRIELHQKDLNLALEGAKALGVSLPNTSTTQQLFNSCAANGGAREDHSALVRALER----MANFEVGGAVAEVKGKAA.... 305
3 -26.600[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  15  1.................MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGED-SLRELSQRLSAPRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTY--------YRDDLRHEKLLFKKGIHLLDCGTSGGGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAAPRTPGRDGEVAPVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETA.......................................................................................................... 228
4 -23.400[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  13  3.................ADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANEAKATSIEDFISKLKRVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSH--------FPDSNRRYEELKKKGILFVGSGVSGGGARYGPSLMPGGSEEAWPHIKNIFQSISACCEWVGPAGAGHYVKM----VHNGIEYGDMQLICEAYDIMKRLGGFTDKEISDVFAKWN........................................................................................................ 222
5 -23.300[G] COG0362 6-phosphogluconate dehydrogenase  ali follow..  15  1.............MSVKGDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKAYSLEDLAAKLEKVMLMVRAGDVVDQFIEALLPHLEEGDIIIDGGNSN--------YPDTNRRVKALAEKGIRFIGSGVSGGGARHGPSIMPGGNQEAWQYVKPIFQAISAKCDWVGGEGAGHFVKM----VHNGIEYGDMQLICEAYQFLKEGLGLSYEEMQAIFAEWK........................................................................................................ 225
6 -21.000[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  15  1..............MSTMKVAVYGAGNQGSRMAIEFAEAGHDVVLAEPARDMLDDAHWKVVETDNDAEAASEAEIAVLFTPFGKKTFEIAKNITNHLPEGAVIANTCTVSLERELRRDRKDLGIASMHPAAVPGTPQHGHYVIGG--HSSSELDIATDEQISRCVELAESCGKVAYVVPADVSSAVADMG-----SLVTAVTLSGVLDYYYVGTQIRAPKEMVEKQILMTLQTIASLVETSGVNGMLKAMNPELLVRSAKSMHLLEEQEELDAALNTLSDLDD-EKGEIRHTDLVAAQALAKEIKNLMGGKAAETIRRCMRKMFE........... 344
7 -18.000[H] COG0499 S-adenosylhomocysteine hydrolase  ali follow..  25  249.......NRATDMLMGGKNVLVCGYGDVGKGCAEAFDGQGARVKVTEADPINALQALMDGYSVVTVDEAIEDADIVITATGNK---DIISFEQMLKMKDHALLGNIGHFDNEID.............................................................................................................................................................................................................................. 352
8 -17.900[H] KOG1370 S-adenosylhomocysteine hydrolase  ali follow..  21  187.........ATDVMIAGKVAVVAGYGDKGKSCAQALRGFRASVIITKTDPIKALQAAMEGYEVTTMDEACQEGDVFVTTTGCV---DIILGQHFEQTKDDTIVCNTGYFDVEMD.............................................................................................................................................................................................................................. 288
9 -17.400[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  16  4...............TKPSIAILGAGRVGSSLARSAVAAGYEVKVAGSGAVDKIALTAEGAVPSTADQAVKDADIVFLAVPLHKFRSVNPATL-----EGKIVIDTMN---ELEEIDQDPRSTSEIIAEFFAGSTMVKSFIEQDAGTGRAIAYATDDVDAGAQVAQLIKSFGFVPLNIGALENGRILE.................................................................................................................................................... 186
10 -15.500[S] COG5495 Uncharacterized conserved protein  ali follow..  13  10...............ARLNIAILSTGRVGVA----LERADQVVVCSAVSHASRQWVQFPETSVASPPEVASSAELLLLAVPDCEFAGLMSG--TSVPRPGTIVAHTSWANGVGILAQLGKDGCIPLAIHPAMMFSGSDEDLSQCQLRDTYFGITKTDDVGYAIAQSLVLEMGGEPFCV-----VEYARILYHSVSPHVGNHIVTVLADALEVRRSALRGSELLGLGVPPACRGEVVDDQLDVIVEARAACENTLQRGQAGLTKLVARGDLDAL--------------AGHLVALMRIGPELAQAYRVNALRKTQRAHAP................. 300
11 -14.400[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  13  1..............MIDMKLAILGAGVDEVVVADPVFDNQFTVIDPPEGAIHFTHPEDLGFEITDDREAVADADFIMTWFPKGDMQPGIIDKFIDDIKPGAIVTHACTIPTTKFYKIFEEKHGDLVTKPETLNVTSYHPGAVPEMKGQVYIAEGYASEEAINTLFELGQKARGNAYRLPAELLGPVCDM----CSALTAITYAGILSYRDSVTQVLGAPAGFAQMMAKESLEQITALMEKVGIDKMEEHLDPGALLGTADSMNFGASADILPTVFEILEKRKK..................................................... 347
12 -14.300[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  15  1..............MENQKIGFIGAGKMGSALMQGTIKAGINIGASDVYEPFLKDLQAKGIRVSDNAVIVRESDILILAVKPQTLSSVL-SNLKNEITSEKLVIIAAGVPLSTYEDALLEGTRVVRVMPNIAA-------TVSEAASG-IAPGKNATPEDLKAALEIFSAVGTAVQ------VPESLMDAVTGLSGSGPAFIFPVIEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETG.............................................................................................. 220
13 -13.900[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  11  363...............SRLKIGIVGFGNFGQFLGKTMVKQGHTVLAYSRSDYTDEAAKLGVSYFSDLDDFEEHPEVIILCTSILSTEKVLESLPFQRLKRSTLFVDVLSVKRNLFLQTLPQDFDILCTHPMF-GPESGKNGWNNLAF-KVRIGMDDRRKSRCNSFLDIFAREGCRMVEMSCAEHDWHAAGSQFITHTVGRLLEKLSLESLLKLVENTAGDSFDLYYGLFLYNPNAMEQLER................................................................................................ 602
14 -13.700[E] COG0287 Prephenate dehydrogenase  ali follow..  18  8.................ERIALIGIGLIGSSIARDVRELGLHVVISTRSEDTLKRAEELALYTVSAAEAVKDADLVIVSVPVGASESVA-QQIAPYLKPSAIVTDVGSTKIAQMAPHMPENVHFIPGHPEKSGPDAGFAGL--RERWCIFTPLPGTDAAALERLKDFWRALGSRVDEMDAEHHDKVLAIVSHLPHIIAYNIVGTADDL................................................................................................................................ 208
15 -13.200[CHR] COG1052 Lactate dehydrogenase and related dehydrogenases  ali follow..  20  144..............LRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPN---DAAKEWLTYVSMDELLSTSDVISLHMPTKDSHHLINAKTIAQMKDGVYLVNTARGAVIDSQALLDS........................................................................................................................................................................................................................ 247
16 -12.300[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  11  2.................LKIGIVGCGFIGGQICRAIDGVSAELYLCDSSESKALELAAS-PSYMKIEELIRGVDLIIESASQNAVRFI----VPQALKAGCDVMILSVGALADEEL............................................................................................................................................................................................................................ 103
17 -12.100[M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase  ali follow..  10  14...............RQALIGIVGLGYVGLPLMLRYNAIGFDVLGIDIDDVKVDKLNASGFEATTDFSRVSECDALILCVPDMSFVINTTDALKPYLRVGQVVSLESTTYPGTTEEELLPRVQEGGLVVGRD-----EREDPGNPNFETRTIPKVIGGHTPQCLEVGIALYEQAIDRVVPVSSTKAAEM-TKLLENIHRAVNIGLVNEMKIVADRMGIDIFEVVDAA--ATKPFGFTPYYPGPGLGGHCIPIDPFYLTWKAREYGLHTRFIELSGEVNQAMPEYVLGK---------MDGLNEAGRALKGSRVLVLGIAYKKNVDDMRESPS.... 348
18 -12.000[C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily)  ali follow..  14  421..............IRDSTVGFYGFGGIGQAVAKRLMGFDIKRMLYTRNRVSQDIEERFNAKKVDFETLLAESDFLIIASPTKETLGLFNATVFNKMKETAVLVNVGRGKIVNQ-------------------DDLYEALKSNRIFAAGLDVMDPEPLPSNDKLLTLDNVVVTP--HVGYATRRTRVDAANLASRNVLKG........................................................................................................................................ 587
19 -12.000[K] KOG0067 Transcription factor CtBP  ali follow..  13  178..............IRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEK-------------------ALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNL---TPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSAPWSVIDQQA......................................................................................................... 375
20 -12.000[S] COG1255 Uncharacterized protein conserved in archaea  ali follow..  20  13...............KKGKVIEVGIGF-YTRIAKRLKELGFDVLAIDINKDAVVNAKNSGLNAEVDDSLYMGAKAIYSIRPTPEMMNYI-LKISKAVKVPAYIVPLTG.................................................................................................................................................................................................................................... 109
21 -11.800[E] KOG0068 D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily  ali follow..  16  219..............LVGKTLAVMGFGKVGTEVARRAKGLGMTVISHD---APADRARALGVDLVSFDQAISTADFVSLHMPTPATKKVFNDETFSKMKKGVRLINVARGGVIDED-------------------ALVRALDAGIVAQAALDVFCEEPPSKDSRLIQHENVTVTP--HLGASTKEAQEGVAIEIAEAVAGALKGELSATAVNA............................................................................................................................ 395
22 -11.700[H] COG1893 Ketopantoate reductase  ali follow..  16  1..............MEKPRVAVIGSGSIGLLLYAYLKLANWPALLVTNRPEQADHLNKEGLTFVAKSFSAEEAEVGFITVKSFAVKALLPQ--LQRKKWDGLVFFQNGMT.................................................................................................................................................................................................................................. 109
23 -11.700[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  12  2................KQHIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERRHTTDMKEAIHNAFMIVEGVT-SAGIRPVAEQLKQITDLSVPFVITSKGIEQNTGLLLSEIMLEVLGDSVTPYLGYLSGPSIAKEVLNGSPCSVVVSAYDSQTLKQIHEAFSLPTFRVY-------PNTDIKGAA--LGGALKNVIAIACGIAEGLSFGNNAKAGLVTRGLHEMRKLAAIMDCVTCFSESSRNLRFGHLLAQGLTF-EQAKAKIGMVVEGAYTALSAYQVAKHHKIDMPITTGIYRVLYENL--DLKEGIALLLQ........... 326
24 -11.700[E] KOG3124 Pyrroline-5-carboxylate reductase  ali follow..  14  1.................MSVGFIGAGQLAYALARGFTAAGIKIIASSPEMNLPTVSALRKMGVRSNKETVKHSDVLFLAVKPHIIPFIL-DEIGADVQARHIVVCAAGVTISSVEKAFQPAPKVIRCMTNTPV-------VVQEGATV-YATGTHALVEDGQLLEQLMSSVGFCTE------VEEDLIDAVTGLSGSGPAYAFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIHA---------------LHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALK................. 283
25 -11.500[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali follow..  14  23.................NNVTIIGAGLMGSGIAQVSANAKLNVTVVDSNQSALEKAQQG--MSTNVSDSVKDADLVIEAIVENIDIKRKLFAEVEVAAKPTTLITTNTSSL---------RLADIGLNLKDKSRFGGLHFFNPVPMMKLLEVVRHTSDATFNQLVDYGKTVGKTTVACKDTGFIVNRLLVPYMFEALRLYERGDASMEDIDVAMKLGAG..................................................................................................................... 248
26 -11.400[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  12  3.................KTVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAGLASLIKGSGDINDLAQADLVIEAVTEDETVKRKIYGQVCPVMRPDAILATNTSSL---------SITRLASATDRPERFMGIHFMNPVPVMKLVELVRGTEEETFKAAKEFVAHLDKTVTVAEDFAFIVNRILLPMINEAIYTLYEGVGTVDAIDTAMKLGAN..................................................................................................................... 222
27 -11.200[HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases  ali follow..  10  165..............VYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYD---ISQERADQIGCTLVDLDLLFSEADFITLHIPTPETANLINAETLAKMKPTARIINCSRGGIIDEE-------------------ALVTAIETAQIGGAALDVFAQEPLGE-SRLREFSNVILTP--HLGASTEEAQVNVAVDVAEQIRDVLLGLPARSAVNILTPDVMEKLRPYLKLAETLGTLVGQLAGGRIDRL--TVCLQGDLAEYTNSQPLVVAAIKGLLSQALRE-ERGIRVIETKDASVRDYSGSLHLKATGTMGEHSATGALLSNGEIRITD....... 468
28 -11.200[R] COG2910 Putative NADH-flavin reductase  ali follow..  21  2.................AKIALIGAGNAGSRILKELSDRGHQVTAIARNPEKIAAKKGDVFDQAALSELLKGHDAVISSVHFTASD---PATLIEAVRASGVYLVVGGAGS................................................................................................................................................................................................................................. 101
29 -11.100[S] COG4408 Uncharacterized protein conserved in bacteria  ali follow..  13  2.................SKLLMIGTGPVAIQLANICYLKSDYIDMVGRASTSYQAYKKEK--YKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKHVILISP.................................................................................................................................................................................................................................... 120
30 -10.800[M] COG1004 Predicted UDP-glucose 6-dehydrogenase  ali follow..  12  1.................MKVTVFGIGYVGLVQATVLAEVGHDVLCIDIDANKVADLKEPGLASTDAQAGVAHGVIQFIAVGDLKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKVHQVIQAILEQRGEKIDFSVVSNPEEGAAVADCKRIVIGIDTDDSGALELISELYEPFNRNHDRMLVMDIRSAELKYAANGMLATKISFMNEIANIAERLGADIEKVRQGI............................................................................................................. 247
31 -10.600[C] KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase  ali follow..  11  23...............KLISVGIIGSGNWGTAIAKICGENAKQVHMWMYEEKIQHEGKECNLTNPDIRDVGSRSDILVWVLPHQ-FVVRICNQLKGCLKKDAAISCIKGVSVTKDRVRLFSDIIEENTGMY-SGANIASEVAQEKFCETTIGYLPNSSVNPRYTPKTIQALFNRPYFRVNIVEDVPGVALGGALKNIVAVAA-LELGDNTKSAVMRIGLLEMQKFGRMFFDCKPLTMSEESCGIADLITTCNHKCAVAFVKTGKPMHVVEQELLDGQKLQGAATAKEVYEFLDNQN......................................... 345
32 -10.600[G] KOG1203 Predicted dehydrogenase  ali follow..  17  112......TEEPVAEMGTSGIILVAGAGGVGRRIVDILRKRGLPVKALVRNEEKARKMLGPEIDLIVVPEKFKGVRKVINAVS............................................................................................................................................................................................................................................................... 196
33 -9.820[R] COG1832 Predicted CoA-binding protein  ali follow..  15  6......KAEIKEILQRSKRIAVVGLSRTSHMVSKAMQDAGYEIIPVNPTIDEAL-----GVKAVSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAP--VFWAQQGLVNEEAYQMLKEKGRTVI................................................................................................................................................................................................................... 122
34 -9.700[Q] COG4569 Acetaldehyde dehydrogenase (acetylating)  ali follow..  16  1..............MSKRKVAIIGSGNIGTDLMIKILRHG--AVMVGIDPQSDGLARAEGVIGLMNMPEFADIDIVFDATSAGAHVKNDAA----LREAKPDIRLIDLTPAAIGPYCVPV........................................................................................................................................................................................................................ 114
35 -9.680[R] COG2344 AT-rich DNA-binding protein  ali follow..  16  69VDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLHFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLVKDESVAILTVPAVAAQSITDRLVALGIK.............................................................................................................................................................................................................................................. 171
36 -9.480[Q] COG5310 Homospermidine synthase  ali follow..  13  1MLDKMANENWPVYGEITGPVVMIGFGSIGRGTLPLIERHFSRMTVLDPRDTDRKLLDERGIAFTPLLTNGGGQGFCVNLSVDTGSVDLMRL-----RKLGVLYIDTV..................................................................................................................................................................................................................................... 121
37 -9.470[R] KOG4288 Predicted oxidoreductase  ali follow..  21  1.................MKIVVLG-GFLGHNICKLAIAKGYEVVSVSRRGAGGLHNKEPWMDPNSLLPVLRDASAVVNSVG............................................................................................................................................................................................................................................................... 77
38 -9.090[MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases  ali follow..  14  31............LANLPPLVTVFG-GFVGRHVVRMLAKRGYRIRVAVRRPDLAGFLQPLG-YRDSIIKAVEDADHVVNCVGDAVQEFGAKAIAEAARDTGATLTHISAIGADANSQTTKGRAEAAIHSVLPGAVILRPSIIFGPE............................................................................................................................................................................................... 190
39 -9.060[H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2  ali follow..  17  133........EALNQDLSMLRVGVIGCGGTGSAIAMLLPKMGINIALFDKDIVEDTNLNRAWIGEADCRDPLKACDVIFCCT-DDHTGRLMLNRFTPVFDMGLAIEVSQG.................................................................................................................................................................................................................................... 273
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.