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Query: IDP04464 gene: hutI; imidazolonepropionase [Yersinia pestis CO92] YPO1972 [Yersinia pestis CO92], from CSGID

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVSVTHCDSLWFGADIITMRGGNYQLIPQGAIAVTGDKIVWIGPHAELPPIHAARQVVYEGGLITPGLIDCHTHLVFGDDRSNEFEQRLNGVSYAEIAANGGGIISTVRATRQASEQQLLEQALFRLKPLLAEGVTTIEIKSGYGLNLESEIKMLRVARRLGELLPIDVKTTCLAAHALPPEFIGQPDDYIDVVCNSIIPQVAVENLADAVDAFCEHLAFSPAQVERVFLAAQKAGLPVKLHAEQLSALRGATLAAKFHAISADHLEYATESDVQAMANAGTVAVLLPGAYYLLRETQCPPIDLFRQYKVPMALASDANPGTSPVLSLRLMLNMACTLFRMTPEEALAGVTCHAAQALGVQQTQGTLETGKLANWVHWPLSHPAELAYWLGGQLPATVVFRGEVRPLast
1 -99.200[Q] COG1228 Imidazolonepropionase and related amidohydrolases  ali follow..  38  1..MVQHFDTLLVNIQLLPMESSELQLLEHAALGIRDGKVAFIGTMVEADTFTANQMIDCQGKLVTPGLVDPHTHLIFGGSREHEMALKQQGVPYLEILKNGGGILATVEATRAASEEELITKAICHLNRMLSYGVTTIEAKSGYGLDRETEWKQLRAAKAVGEQHPIDIVSTFLGAHAIPTSHRNDPDRFLDEMAD-MLGEIKEQNLAEFVDIFTETGVFTVEQSRTFLQKAKERGFGLKLHADEIDPLGGAELAGELGAISADHLVGASDQGIQKMAAAGTIACLLPGTTFYLGKDTYARARDMIDQGLAVTISTDFNPGSSPTENLQLIMSIAALRLKMTPEEIWHAVTVNGAHAIGRGDTAGQLAVGRAADVVVWDAKNYYYVPYHYGVNHVHSVWKKGEV.. 411
2 -70.200[FQ] KOG3968 Atrazine chlorohydrolase/guanine deaminase  ali follow..  12  5..QMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGIVFLEEASQQEKKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRF---------QNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDLADITDKFGQRAFVGKVCMDTTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLM-----------------GELGNIAKTRDLHIQSHISENSYKNYTSVYDKNNLLVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFL-NVLEVLKHEVKIGLGTDVAGGSYSMLDAIRRAVMVSNILLLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKAIQKFLYLGDDRNIEEVYVGGKQ.. 446
3 -63.200[FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases  ali follow..  15  3.......QQLIKNGLVLDMKGNH--KPQAKDILIEGKWIRDIRPNIEPEV--DTEIIDAEGKIVMPGFVDTHRHVWESLLRHIGTDWTLLTYLDNLYYGNLG---------SMLTPEDSYIANLWGALEAIDAGVTTVLDWSMHADASIKGLQAAGIRAVFAHGTPDSEVRHPKDAKRVKKEYFQSDDQLLTMALAIRGPEFSSW-----------------EVTLDDIQLARELDAIASMHIGFGPHDRSITRMREAGLLNLVHVNRIQPHEYEYIAESGASLSVTPEVEMMMGHGY-PATGYLHKHRGLVTLGVDVVVATA--GDMFAQMKFALQAERMTTNDVLTFATLNGAKALKLDDKIGTLDVGKEADLLLINPSSFNAVVQSARPENVDSVFIAGRP.. 414
4 -48.800[P] COG3454 Metal-dependent hydrolase involved in phosphonate metabolism  ali follow..  15  2.....PKEQLLTNARIVLEDR-----ILDGSVLIRDGRIADISEGA------SAAGEDFEGDYLLPGLVELHTDHLEAHYRPGVRWLKIAAIQAHDAQVVTSGITTVFDCLRLGSDEDSGFGEMRSMADALAQAKQEGRLRADHLIHLRCEVSTADVLEHYEDFRNDPQVRLVSLMDHAPGQRQFQTMDQYTLYYKTKRGLTDDAFAAFIERQQALSARYATPHRNALAKACAERGITVASHDDA-----TVEHVEESIGYGIRLAEFPTSFEAAEASHRAGLSVLMGAPNIVRGKSHSIAARDLAKRGVLDVLSSDYVPFSL----IHAPFILADEVESIGLPEAIAMVTATPARTVGLEDR-GRIAVGLRADIARVRRPE--------GIPVVRTVWREGRR.. 377
5 -43.100[R] COG3964 Predicted amidohydrolase  ali follow..  13  41....LQAPILLTNVKPVGFGKGA--SQSSTDILIGDGKIAAVGS--ALQAPADTQRIDAKGAFISPGWVDLHVHIWHGGTDI------------------------------SIRPSECGAER--GVTTLVDAGSAGEANFHGFREYIIEPSRE-------RIKAFLNLGSIGLVACNRVPELRDIKDIDLDRILECYAENSEHIVGLKVRASHVITGSWGVTPVKLGKKIAKILKVPMMVHVGEPPALYDEVLEILGPGDVVTHCFNGDEDLFNLAERCAGEGIRLDIGHGGASFSFKVAEAAIARGLLPFSISTDLHGHSMNFPVWDLATTMSKLLSDMPFENVVEAVTRNPASVIRLDM-ENRLDVGQRADFTVFDLVDADDVSRLKRLFEPRYAVIGAEA.. 414
6 -37.800[R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold  ali follow..  19  33.VDTMHPDLILHNGRVTTLDRTNPNA---TAIAIKDGLFLEVGSDSEVMAGSGTKIVDLKGKGVLPGLIDNHTHVVRGGLNLNGAALRAVGYTRDTPNPPGGEITSTLAKGPKLPLDYQVNSTRHFMRELNRLGVTGVIDA---GGGFQNYPDDYEVIQKLSDENQMTVRLAYNLFTQKPKEEKQDGNDYFRHNGAGEMLVFSAADFEDFRQPRPEMAPEMEGELEEVLRVLAENRWPWRLHA--TYDETISRALDVFEKVNFDHAETISDRSIDRIAALGGGIATQHRMAYQ-VAEATPPIRRMLDKGVNVSAGTDATRVANPWVSLSWMVTGKTV-NCLDRETALRMWTEKVTWFSNEEGKKGRIEKGQFADLVVPDKDFFSCAEDEISFIVSELTMVGGKI.. 567
7 -32.900[C] COG1229 Formylmethanofuran dehydrogenase subunit A  ali follow..  11  2.....AGTIAIKNGYVFDPLNEINGEKMD--IFIRDGKVVKELSSAEMK---EAKVIDASGMTVMPGGVDSHSHVAGAKVNAGRSMRP----------EDHYKANLNKTALTHSGSGYTVPSVFKQGYDYAAMGYTTVFEAAVPPLEARHTHEEMRATPLLDMGGYLVLGNNFFLMRYIRNGDMEKAAAYVAWMMKTHENWAWGKNVSDLDEANIHFEITPREVIKGLTEINETLGMPMPVHLHANNLGHPGCYAITKDSLKIPYLTHLMFNSFAGTTWADCESGVKDIADYILQWAMGLECLLLINDPWKTIMTTDSPNGGPFTKWANDRSALGGVNRELSLYDLAILTRANPAKTIGMAHRKGSLGEGADGDVTVYNLNPQQL---LRTFRKAEYTVKGGEI.. 517
8 -26.500[F] KOG2584 Dihydroorotase and related enzymes  ali follow..  13  9IPRITSDRLLIRGGRIVNDDQ-----SFYADVHVEDGLIKQIGE--NLIVPGGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPAD----DFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYERWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQVLSHPEEVEAEAVYRAVTIAKQANCPLYVKVMSKGAADAIAQAKRRGVVPITASLGTDGSHYW-WAKAAAFVTSPPVNP---DPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEVVISQGRV.. 452
9 -26.100[F] COG1001 Adenine deaminase  ali follow..  15  27....EPADMVLKGGRFFDLVTGE---LVASDIAICGDTVVGTCGDYK-----GRHEIDISGKIVVPGFIDTHLHI-----------------------------------------ESSLVTPHEFDRCVLPYGVTTAIC----PHEIANVLGAEGLQFFLDSAMETIMDIRVQLSSCVPATHLETSGADLP---IEKLLPFRNHPKVIGLAEFMNFPGVIHKDPVCMAKLEAFQGQHIDGHAPLLSGAALNGYLAA---IRTEHECTSAAEALEKI-RKGMHILVREGSVSKDLHALMPIITERLSPYLALCT-DDRNPLDIAEQGHLDYMIRTAIASGVEPLAIYRAASISAAKAFGLRD-RGLVAPGWRADLVVID---------TLQNCKASMVLSGGRL.. 357
10 -26.000[E] COG0804 Urea amidohydrolase (urease) alpha subunit  ali follow..  11  61SRAQGAVDTVITNALVVDAGAG----IFKADIGLKDGRIAAIGKAVTIIIGPGTEIIAGEGKILTAGGFDAHIHFICPQQIEEALMSGITTMLGGGTGPAHGTLATTCTPGPWHMARMIQSSLPAALEEMVLGGACSLKLHEDWGTTPAAIDCCLSVADDYDVQVMI---------HTDTLNESGFVENTVAAIKGRTI----------------HAFHTEGAGGGHAPDIIKVCGLPNVISSTNPTRPYTVNTLAE----HLDMLMVCHHLSPS--IPEDIAFAESRIRKETIAAEDI-----LHDIGAFSIISSDSQAADKMKRQRGALPQETGDNDNFRVRRYIAKYTINPAIAHGLSKDIGSIAVGKRADLVLWNPAFFGVKPDMVLVGGMIAAAPMG.... 461
11 -24.700[F] COG0044 Dihydroorotase and related cyclic amidohydrolases  ali follow..  17  1.MAKTGASKVIKGGTVITADR-----TFRADILIEDDKIAAIGDSLE-----GDEVIDASGCYVMPGGIDPHTHLQMPFMGTYSSD----DFDTGTAAALAGGTTMVVDFVLPDSEGNLLDATFNEMVEVVKRGINTFKHFMAYGALMVNDDEMFASFQRCAE------LGAMPLVHAENGDIVAQLQAKL----------MAEGNDGPEAHAYSRPPEVEGEATNRAIMIADQAGVPLYVHVSCEQSHEAIRRARQKGI-PLIQHLTLDESEYH---DYAARRVMSPPFR---DKLNQDSLWAGLAAGSLQCVATDHCAFTTEQKRMPVLWTRGVRTGRLTPNEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPEATKKISAKTQHSSIDMTLSRGRI.. 437
12 -24.300[G] COG1820 N-acetylglucosamine-6-phosphate deacetylase  ali follow..  14  2........YALTQGRIFT----GHEILDDHALVVANGLIDRVCPMAELPP--GIEQRSLNGAILSPGFIDVQLN--------------------------GCGGVQFNDTAEAVSVETLEIMQK----ANEKSGCTNFLPTLITTSDELMKQGIRVMREYLEKHPHQALGLHLEGPWLNLVKKGTHNPDFVRKP--------------------------DAALVDFLCDNA---VITKVTLAPEMVPADVIAKLANAGIVSAGHSNATLKEAKAGFRAGITFATHLFNAMPYITGREPGLAGAVLDKGDKLCLVTDATAPSGSSLTMIEGVRNLVAHCGIALDEVLRMATLYPARAIGVDKHLGSIAPGKVANLTAFTHD------------KIIKTIVNGDE.. 378
13 -18.200[Q] COG3653 N-acyl-D-aspartate/D-glutamate deacylase  ali follow..  11  10LEETVTYDVIIRDGLWFDGTGNA-----TRTLGIRDGVVATVAA-GALDETGCPEVVDAAGKWVVPGFIDVHTHYDAEVLLDPGLRESVRHGVTTVLL---GNCSLSTVYANSEDAADLFSRVEAVPREFVLGALRTWSTPAEYIEAIDALPLGPNVSSLLGHSDLRTAVLGLDRATDDTVRPTEAELAKMAKLLDEALEFATWRERRKLISVLRHRGRILLFFLASSRIFNRRKGVRMSMLVSADAKSMPLAVHVSFGAIADERGLHPLDAFLDVLVDNGERNVRWTTIVANHRPN---QLNKLAAEPSVHMGFSDAGAHLRNMAFYNFGLRLLKRARDLSIERAVYRLTGELAEWFGIGA--GTLRQGDRADFAVIDPTHLDE-MVNRNDATVVATGVGGTV.. 573
14 -13.900[F] COG1816 Adenosine deaminase  ali follow..  11  13................................................................LP--CEHHVHL-LAKKNGITLPSDDAAYTTPSTLLASYEHFGCLDDFLRYEASDFEALAYEYFSIAHSQGVHHAEVFFDPQTHTSRGISYDVVVSGFSAACERANRDFGMSTNLIMCFLRHLPSEAAHETFAEALKRNDENGIVAGVGLDSSEVDFPPELFQEVYKLAAEKGIRRTGHAGEEGDPSYISGLDNLSLQRIDHGIRLVEDKMKRVAEENIMLTMCPLSNLKLRC----PVREFLEAGVPFSINCDDPAYFGG--YTLENYFAIQKHFNLTVKE-WVFIANAAINGSWISGK........................................... 333
15 -13.500[F] KOG1096 Adenosine monophosphate deaminase  ali follow..  8  692............................................................................................................................................................................................................................NICALNAFRRARGLNTFALRPHCGEAGHVSHLLTG--LTSESIAHGILLRKVPQYLYYLTQIGIAMSPLSNNSLFISYQRPLPEYLQKGLNVSLSTDDPL-HYTKEALMEEFSIAAQVWKLSSCDMCELA-RNSVMQSGFEDKLGPNYKEEGVDIHRTNVPDIR-VSFR................. 869
16 -13.200[F] COG0418 Dihydroorotase  ali follow..  9  2............................................................EKLTITRPDDWHLHLRDGAALKAVLPHTVRQFARAIVMPNLKPPVRSVADAAAYRERILAAIPAGGQFEPLMTLYLT-DNTNPEEIIAAKASQFVKAVKYYPAGATTNSDFGVTDIHRCDAVLAAMEQVDLPLLLHGEVTDSNIDIFDREKVFI---------EKYLIPLREKFPRLRVVLHITTSDAVQFVLSANNIAATITPQHLLFSRNALF--GGICPHFYCLP---LKREEHRLSLLHAATSGNPKFFLGTDSAPHARNSALHAMELYAEAFESVNSLDKLEAFASFYGPDFYQLPR----------NTAQITLMKNPWRI-------PAELPFPESGLVP 330
17 -12.800[F] KOG2902 Dihydroorotase  ali follow..  10  2.............................................................SLKIPGLADMHVH------------LRQDNMLKAVVPTVAEGGVSVAYVMPNLIPPITTVDACLQYKKEIEQLDSKTTYLMSLYLSPETTPEVIYEAAKKGIRGVKSYPKGATTNSESGVESYEPFYPTFAAMQETGMILNIHGEVPPSKDN--TVFTAEPKFLPTLLDLHQRFP-KLKIVLEHCTTADAVEAVKACGGTITAHHLYLTQKDW----QDDPYCFCKP---AKTERDRRALIEAATSKNPKFFFGSDSAPHPRSTQPFAASYLAEVFDKEGRLDALKDFACIFGRKFYCI--------PLDFKESNIVLKKESFRVPESVANDLVPNEVLQWHCS. 335
18 -10.000[F] KOG1097 Adenine deaminase/adenosine deaminase  ali follow..  12  128................................................................MPKGAALKAHDPMEKLRELRGEENLRKYLQMRFSMYPLASFTTNAHAWRQYAPVWGDYYYNALKEFYADGVQYLEVRSVLPQLYSLDGSRMPKRETVTLERFKKEHPGFIDSKLIYAPIRHVQPELVGEYIKECTELNKEPSFVVGFDLVGQEDVGHPLSNFAAELLKLPDHIHFYFHAGQTNWYGSLLDAIVLGTKRIGHGYTITKHPMRLAKYLNIALEVCPVSNQVLQL----PAATLIAENVPMVIASG-SPGFWRAAPLSHDFYMAFLGIAPMDLKFLKRTAKNSIKY-------SSLKDEAKAEAM.............................. 512
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Wyrwicz LS, Godzik A, Kloczkowski A, Rychlewski L. Support-vector-machine classification of linear functional motifs in proteins. J Mol Model 2006 Aug;12(4):453-61. Epub 2005 Dec 10.