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Query: gi|238922438|ref|YP_002935951.1| DNA gyrase, A subunit (EUBREC_0006) [Eubacterium rectale ATCC 33656], from E.rectale

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDDKIFDQIQQVDLKKTMESSYIDYAMSVIASRALPDVRDGLKPVQRRVLYSMVELGNTPDKPHRKCARIVGDTMGKYHPHGDSSIYGALVNMAQDWSMRYTLVDGHGNFGSVDGDGAAAMRYTEARLSKISLELIKDIGKNTVDFEPNFDETEKEPTVLPSRYPNLLVNGTTGIAVGMATNIPPHNLREVVNAVVRLIDNDIEDKETTIDELIDVVKGPDFPTGGIILGTSGIKEAYRTGRGKIRVRAVTNIEPMENGKNRIVVTELPYNVNKARLIEKIAELHKDKKIDGITDLRDETSREGMRIVVELRRDVNPSVVLNLLFKHTQLQDTFGVINLALVNGEPKVLNLYDLLNYYLIHQKDVVTRRTKFDLDKAEARAHIVEGLIIAQDNIDEVISIIRSSQTTQQAKTRLMERFGLTDEQSQAIVDMRLRALTGLEREKLEAEYKELMAQIAQLKAILADEKKLLGVIREEIIAIADKYGDDRKTEIGYDEYDMSMEDLIPETNTVITMTKVGYIKRMSTDNFKAQHRGGKGIKGMETIEDDYIVEMLMTTSHHYLMFFTNTGRVYRIKAYEIPEASRTSRGTAIINLIPLQPDEKITAMIPIKEYEDDKYLFMATRNGIVKKTPIKDYENIRKNGLAAINLREDDKLIEVKVTDNSEDILLFTKFGQCIRFKETDVRSTGRTTMGVIGMNLAPNDVIIAMQTASMGEAVLLVSSNGLGKRTRIDEFTTQNRGGKGVKCYKITEKSGNLVGVKSVENDDELMLITTEGIIIRIQVSDVTVLGRITTGVKLINLKEGVSVASIAKVVEDKTLMPPEEAKEENDESENSDEDSAENNNSHAEAIENNTEALast
1 -161.000[L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit  ali follow..  42  2..FNKDEIIVPKNLEEEMKESYLRYSMSVIISRALPDIRDGLKPSQRRVLYAMKQLSLSPGAKHRKCAKICGDTSGDYHPHGESVIYPTLVRMAQNWAMRYPLVDGQGNFGSIDGDPPAAMRYTEARLTHSAMYLMEDLDKDTVDIVPNYDETKHEPVVFPSKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLLLAN----PQASVDEILQVMPGPDFPTGGIICGSEGIRSAYTTGRGKIKVRARLHVEENEKHRESIIITEMPYNVNKSRLIEQIANLVNEKTLAGISDVRDESDKDGIRVVLEIKKGESSEIIINRLYKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRKEVIRRRTRYELNKAETRAHVLEGYLKALSCLDALVKTIRESGNKEHAKERIIESFGFTEPQALAILELRLYQLTGLEAEKIQKEYEELLNKIAYYKQVLSDEGLVKDIIRNELQDLLKHHKVARRTTIEFDADIRDIEDIITNESVIITISGDDYVKRMPVKVFKEQRRGGHGVTGFDMKGAGFLKAVYSAFTKDYLLIFTNFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEELAILNIKNFDNAGFLFLATKRGVVKKVSLDAFSNPRKKGIRALEIDEGDEIAACHIVSDEEKVMLFTHLGMAVRFPHEKVRPMGRTARGVRGVSLNEEDKVVSCQIVTENQSVLIVCDQGFGKRSLVEDFRETNRGGVGVRSILINERNGNVLGAIPVTDHDSILLMSSQGQAIRINMQDVRVMGRSTQGVRLVHLKEGDALVSMEKLSSNENVLSGSEEECSDTVSLR...................... 834
2 -9.500[D] COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins  ali follow..  17  336......................................KRLLHKNAEKLRKTLESFGVK--------AHVSGPAVTKYEVNPHVGVVSRIVNLADDLALALAAIPGKSAIGEVPNQEVAIVTLREV--NVLSVGLGRDISGEPV-----------------NKMPHLLVAGATGIITSILLKAKPHEVK-MIDPKMVELNVYNGIPHL----LTPVVTEPKKASQALKKVVAEMERRYDSHSGTRNIEGYNEMITRQNEKEDAKQPTLPYIV----IVDELADLVASGDVEDIARLAQMARAAGIHMILATQRDVITGVIKANIPSRIAFGVSSQTDSRTILDGAEKLLGRGDML--YLPMGATKPTR---------------VQGAFLSDEEVETIVEFVVAQQKAQYAEEMTPTE-ELYDDAVNLVIEMNSASVSMLQ-RRFRIGYTRAARLIDEMEA........................................................................................................................................................................................................................................................................................................................................................................................................ 762
3 -9.200[L] COG0417 DNA polymerase elongation subunit (family B)  ali follow..  12  498.....KDAYLPQRLMDKLMCFVNYTEMARVTGVPFNFLLARGQQVISQLFRKALQHDVPNIRVNGTDEQYEGATV--IEP--IKGYYDTPI-ATLDFSSLYPSIMQAHNYTTLLDSTPNGDYFVKPHVRKLLPIILADLARKKAKADLKKETDPFKKAVLDGR--KVSANGFTGATNGISSSVTSYG-RQMIEKTKDVVEKRYRIENGYSHDA-VVIYG-DTDSVMVKFGVKTLPEAMKLGE-SDQFPNPIKLEFEKVYFPYLLISKKRY----AGLFWTRTDTYDKMDSKGIETVR----RDNCPLVSYVIDT-----ALRKMLIDQDVEGAQLFTKKVISDLLQNKIDMSQLVYAAKMAHVELAERMRKRDAGSAPAIGDRVAYVIIKGAQGDQFYMRSEDPIYVLENNIPIDAKYYLENQLSKPLLRI..................................................................................................................................................................................................................................................................................................................................................................................................................................... 952
4 -8.570[L] COG4581 Superfamily II RNA helicase  ali follow..  16  234.....KRSIVSLPPSTLNLHKQPDYAHVVDSSAPIENFQQ-LDNFQKEAIYHLEMGDSVFVAAHTSAGKTV---VAEY--HMTKAIYTSPIKALSNQKFR-DFKHKFEDVGILTGDGSCLLMTTEILRSMLGADLIRDVE-DEVHYVNDLEGVVWEEVILPPHVTLILLSATVPNTKEFATLKRPVPLEHYLQNMFKIVDQHGRFLMDGYKSANDALKKPDKPVIAKDNKNSARGRGAARGRGV---MRGRGSAKSVERRDANTWVHLIGHLHKQNLLPVIVFVFSKKRCEEYVDLNNHQEKSEVHVVIELSRGLAVKEIVEILFQRGLVKVLFATETFAMGVNMPAKSVVFSGTQKHDGRNFRDLLPGEYTQCSRAGRRGLDVTGTVIILSR-SELPDTASLRHMIMGPSSKLISQFRLTYNMILNLLRVETLRIEDM-IKRSFSENVNQTLVPQHEEKIKSFEEKLSALKKEMSDVDLKEIKSCLLSSESFKEYTKKMHFRAITTANGKRIFKDGRVIVF.......................................................................................................................................................................................................................................................................................................................................... 831
5 -7.850[T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain  ali follow..  15  328.............................VTKEVEAENRDTLTGLANRTNF-REQLDARLAAPEARLGKLVNDTKG--HRAGDALLERVAQRLRAVCDRPGMAIARLG------GDEFAVL--DADRAATLATALIEALG---------------APYALGAD--NVRIGASIGIALAPAHGRDTENLLARADIALYAAKETRIQARALLEQLRAALEHQD-AERGWVPPDEFVPIAEQSG-GRFVLHRACREATRWEDGARVAVNVSPMQLGKATLAQTVHAALIDSGLAP-------------RLEIEVTETANEAESFEDLRQLYDM-DDFGTGYSSLAHLRAFPFDKIKIDRSFVR------------DLLERPDSAVLVRAIADLGRQLG--VTTVAEGVETQAHVRGIREA-GCTEAQG........................................................................................................................................................................................................................................................................................................................................................................................................................................... 743
6 -7.840[O] KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain  ali follow..  14  659........TAKEDFTKALDRSKKRNASALGAPK-VPNVKGGLEDVKTSILDTV-QLPLLHKDLFSSGLRKRSGVL--YGPPGTGKTLLAKA-VATECSLNFLSVKGPELINMYIGESEKNVRFEKARSARPCVIFFDELDSLAPARGASGDSGGVMDRVVSQMLAEILSDSSQDLFIIGASNRPPGRFDKLLRVLKALTRKFKLSEDVSLYSVAKKCPGADMYA---LCADAWFQAA----KRKVSKSDSGDMPTEEDDPDSVVVEYVDFI----KAMDQLSPSLSITELKKYEMLRDQFQGR..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 971
7 -7.690[TW] KOG1226 Integrin beta subunit (N-terminal portion of extracellular region)  ali follow..  14  65....................................DLKENLLK-PESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQDDSKNFSIQVRQVEDYPV-YYLM-----------DLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGF-GAFVDKPVSPYISPPEALENPC--YDMKTTCLPMFGYKHVLT-----LTDQVTRFNEEVKK-QSVSRNRDAPEGGF----DAIMQA------------------------TVCDEKIGWRNDASHLLVFTTDIALDGRLAGIVQPNDGQ-----------------HVGSDNHYSASTTMD-------------PSLGLMTEKLS---QKNINLIFAVTENVVNLYQNYSELIPGTTVGVMDSSNVLQLIVDAYGKIRSKVEL...................................................................................................................................................................................................................................................................................................................................................................................................................................................... 383
8 -7.510[L] COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)  ali follow..  13  380TAENDKGEREPSEAARFYQEQF---------HEVLVDEYQDTNLVQESILQLVTSGPEETGNLF-----MVGDV--------KQSIYGRKIDLNKNFRSRADILDSGGKIGEVDYDEQAELKYPDNDETETELLLINAEDTDASEEAEELETVQFEAKAIAKEIRKLISSPFRDIVI-IMEELRAQGIPVYANLTSGYFEAVEVA---VALSVLKVIDNPDIPLASVLRS--GADE----------------------------LSLIRLENKKAPYYEAMKDYLAAGDRSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVG----GMPGGKQRQANLRVLYDRARQYESTAFRGLFRF-IERMQERGDDLGTARGLSEQEDVVLMTIHSSKGLEVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMRRELLSEELRVLYVALTRAKEKL................................................................................................................................................................................................................................................................................................................................................................................. 878
9 -7.330[T] KOG4721 Serine/threonine protein kinase, contains leucine zipper domain  ali follow..  15  134.....................................................................LFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISGSGAQGAV-----GKFRAEEVAIKKVREQNETDIKPNIIAF---KGVCTQAPCY--CIIMEYCAHGQLYEVLRAGRKITPRLL-GIASGMNYLHLHKIIHRDLKSPNVLDAVKISDF----------GTSKELSSFAGTVVIRNEPVSEKVDIWSFGVVLWELPYKVDSSAIIWGVGS-------------------NSLHLPVPSTCPDGFKILMKQTWQSKP-------------RNRP---SFRQTLMHLDIASADVLATQETYFKSQAEWREEV-----------KKHFEKIKEGTCIHRLDEELIRRRREELRHALDIREHYERKLERAN--NLYMELSAIMLQLEMREKELIKREQ................................................................................................................................................................................................................................................................................................................................................................................................. 505
10 -7.260[Z] COG5022 Myosin heavy chain  ali follow..  12  74............DADDLTDLSYLN-----------PSVLDALS-YNQLQIYTYSGIVLIAVNPFQRLPNLYTEIVRAYSPHAEDS-YKCMNQEHKNQTI---IISGESGAGKTV-SARYIMRY----FASVQAL-----QSTDSNFHEAPQLTAVENEILATN-PIM--------AFGNSKTSRNDN-ATIIGAKIYLLERSQPNQERNYHIFYQILAGSSSEQLEKWKLVENSQENYLKQGNCSTIEGVNDKEEFKATVDALKTVGIDND-TCECIFSLLAALLHIGNIEVKHSRNDAYKNENLINATSLARDSVAKFLYASLFDWLVATINKALSFIGVLD---KKNSFEQFCINYANEKLQQEFYRHVFKLEQEEYAAEGLNWSYIDYQDNQQCISMIESRLG---ILSLLDEECRMPTNSDENWVS------------KLNDAFSKPEFKNSYQKSRFGNKEFTIKHYALDVVYCAEGFIDKNRDTISDELLE------------LFTNSDVPFVKDLVLFRLEQTAPPADTKKIKTKPKSNTLGSMFKSSLVSLMSTINETNAHY-----------RCIKPNEEKEAWKFDNQMVVSQLRACGVLET----IKISCAGFPSRWTFDEFVSR........................................................................................................................................................................................................................ 713
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.